Best TWAS P=7.74e-08 · Best GWAS P=3.66e-09 conditioned to 0.0122
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Caudate basal ganglia | C10orf11 | 0.35 | 0.27 | lasso | 4 | 0.25 | 9.8e-08 | -5.2 | 5.1 | 2.7e-07 | -0.87 | 0.10 | 0.90 | FALSE |
| 2 | GTEx | Brain Cortex | C10orf11 | 0.32 | 0.15 | lasso | 8 | 0.21 | 1.4e-06 | -5.1 | 5.4 | 7.7e-08 | -0.86 | 0.03 | 0.96 | TRUE |
| 3 | GTEx | Brain Frontal Cortex BA9 | C10orf11 | 0.33 | 0.18 | enet | 11 | 0.19 | 9.3e-06 | -5.2 | 5.3 | 1.2e-07 | -0.91 | 0.03 | 0.96 | FALSE |
| 4 | GTEx | Muscle Skeletal | C10orf11 | 0.11 | 0.13 | lasso | 3 | 0.12 | 5.1e-12 | -5.1 | 5.2 | 1.8e-07 | -0.86 | 0.23 | 0.77 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | C10orf11 | 0.20 | 0.23 | lasso | 4 | 0.23 | 1.1e-29 | -5.1 | 5.1 | 3.1e-07 | -0.84 | 0.23 | 0.77 | FALSE |