Hub : Traits :

Hair/balding pattern: Pattern 2

157 significantly associated models · 35 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 169191860 171407761 2 1 2.0e-09 1.7e-14 5.1e-13 11 PRRX1
2 4 14310407 16125136 2 1 2.0e-12 6.2e-11 2.6e-01 97 CPEB2
3 4 80488345 82578407 2 1 2.3e-12 1.9e-12 1.0e+00 100 C4orf22
4 6 133319409 134100937 1 1 9.9e-08 4.4e-08 7.3e-03 76 EYA4
5 7 18364750 19854141 1 1 1.4e-11 7.6e-18 6.4e-08 60 TWIST1
6 7 148480233 149855335 1 1 7.4e-08 7.8e-08 3.0e-01 96 ZNF746
7 10 31857752 33353843 1 1 1.4e-08 5.2e-10 6.6e-03 81 EPC1
8 10 76664253 79018276 1 1 7.7e-08 3.7e-09 1.2e-02 82 C10orf11
9 13 100044673 101879559 1 1 1.3e-08 7.2e-11 7.4e-06 53 PCCA
10 14 61505657 61992400 1 1 4.8e-11 1.8e-11 4.4e-09 24 TMEM30B
11 15 56896007 58298129 2 1 2.3e-10 8.1e-09 1.8e-01 94 LINC00926
12 17 42607368 43913030 5 1 8.2e-10 1.4e-06 1.6e-02 75 MAPT
13 17 44788310 45796313 4 1 5.1e-10 7.6e-10 1.0e+00 100 LRRC37A2
14 17 62973790 64251733 1 1 1.8e-12 1.0e-12 1.0e+00 100 AXIN2
15 20 21043102 22430527 1 1 4.2e-12 1.6e-25 2.7e-15 43 RPL41P1
16 20 30591354 32083711 2 1 3.6e-08 1.9e-07 7.2e-01 100 COMMD7
17 21 36163513 36656310 1 1 1.5e-17 2.0e-23 3.2e-08 69 C21orf96

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Depressed Affect (Nagel 2018) 4.79 2 2 4.4 0.00 1.00000 LRRC37A2 MAPT
Depression (Nagel 2018) 1.77 2 0 0.0 0.00 1.00000 LRRC37A2 MAPT
Intelligence (Savage-Jansen 2018) 1.42 2 0 0.0 0.00 1.00000 LRRC37A2 MAPT
Neuroticism (Nagel 2018) 5.62 2 2 4.4 0.00 1.00000 LRRC37A2 MAPT
Worry (Nagel 2018) 3.63 2 2 4.4 0.00 1.00000 LRRC37A2 MAPT
Reaction Time 1.30 1 0 0.0 0.00 1.00000 COMMD7
Breast Cancer 2.02 2 0 0.0 0.00 1.00000 LRRC37A2 MAPT
Ovarian Cancer 4.77 2 2 4.4 0.00 1.00000 LRRC37A2 MAPT
Crohns Disease (2012) 2.11 1 0 0.0 0.00 1.00000 ZNF746
Mean Putamen Volume 2.01 2 0 0.0 0.00 1.00000 LRRC37A2 MAPT
Neuroticism (2016) 2.33 2 0 0.0 0.00 1.00000 LRRC37A2 MAPT
Primary Biliary Cirrhosis 2.03 2 0 0.0 0.00 1.00000 LRRC37A2 MAPT
Schizophrenia (2014) 1.11 1 0 0.0 0.00 1.00000 LRRC37A2
Blood Eosinophil Count 3.14 3 3 6.7 0.00 1.00000 C21orf96 LRRC37A2 MAPT
Blood Platelet Count 1.08 6 2 4.4 0.67 0.14687 C21orf96 COMMD7 CPEB2 LINC00926 LRRC37A2 MAPT
Blood Red Count 5.82 3 2 4.4 0.00 1.00000 C4orf22 LRRC37A2 MAPT
Blood White Count 0.73 4 0 0.0 0.60 0.40049 EPC1 EYA4 LRRC37A2 MAPT
Heel T-Score 3.57 6 5 11.1 -0.19 0.71266 CPEB2 EYA4 LRRC37A2 MAPT PRRX1 TWIST1
BMI 0.47 1 0 0.0 0.00 1.00000 C4orf22
Height 1.33 8 4 8.9 -0.47 0.23943 AXIN2 C10orf11 EPC1 EYA4 LRRC37A2 MAPT RPL41P1 ZNF746
Waist Hip Ratio (WHR) 4.69 5 4 8.9 -0.03 0.96662 AXIN2 EPC1 LRRC37A2 MAPT PRRX1
Systolic Blood Pressure 3.45 5 2 4.4 -0.86 0.06300 C4orf22 COMMD7 CPEB2 LRRC37A2 MAPT
Smoking Status 1.63 3 0 0.0 0.00 1.00000 LRRC37A2 MAPT PCCA
Cardiovascular Disease 2.62 1 1 2.2 0.00 1.00000 C4orf22
Respiratory disease 1.22 1 0 0.0 0.00 1.00000 EPC1
Lung FEV1/FVC ratio 1.76 4 1 2.2 -0.59 0.41208 C10orf11 EYA4 LRRC37A2 MAPT
Lung FVC 6.84 4 4 8.9 -0.72 0.27884 C10orf11 LRRC37A2 MAPT TWIST1
Neuroticism 5.38 2 2 4.4 0.00 1.00000 LRRC37A2 MAPT
Hair Pigment 0.79 8 5 11.1 -0.47 0.23803 AXIN2 C4orf22 COMMD7 EPC1 LRRC37A2 MAPT RPL41P1 TWIST1
Tanning 0.54 1 1 2.2 0.00 1.00000 COMMD7
Hand grip strength (left) 2.92 3 2 4.4 0.00 1.00000 LINC00926 LRRC37A2 MAPT
Number of treatments/medications taken 1.27 1 0 0.0 0.00 1.00000 COMMD7
Sensitivity / hurt feelings 5.30 2 2 4.4 0.00 1.00000 LRRC37A2 MAPT
Frequency of depressed mood in last 2 weeks 2.02 2 0 0.0 0.00 1.00000 LRRC37A2 MAPT
Relative age of first facial hair 8.14 4 3 6.7 0.94 0.06083 C4orf22 LRRC37A2 MAPT TWIST1
Systolic blood pressure, automated reading 3.01 3 1 2.2 0.00 1.00000 C4orf22 LRRC37A2 MAPT
Vitamin and mineral supplements 2.18 1 0 0.0 0.00 1.00000 LRRC37A2
Impedance of leg (right) 0.69 2 0 0.0 0.00 1.00000 LRRC37A2 MAPT
Trunk fat percentage 1.44 3 2 4.4 0.00 1.00000 LRRC37A2 MAPT PRRX1
Hand grip strength (right) 2.18 2 2 4.4 0.00 1.00000 LRRC37A2 MAPT
Fed-up feelings 3.12 2 2 4.4 0.00 1.00000 LRRC37A2 MAPT
Relative age voice broke 4.78 2 2 4.4 0.00 1.00000 LRRC37A2 MAPT
Heel bone mineral density (BMD) T-score, automated (left) 2.30 1 1 2.2 0.00 1.00000 EYA4
Qualifications: CSEs or equivalent 2.69 2 0 0.0 0.00 1.00000 LRRC37A2 MAPT
Serious illness, injury or assault to yourself 1.08 1 0 0.0 0.00 1.00000 COMMD7
High blood pressure 3.03 3 1 2.2 0.00 1.00000 C4orf22 LRRC37A2 MAPT
Medication: Atenolol 1.47 1 0 0.0 0.00 1.00000 C4orf22
Medication: Levothyroxine sodium 1.54 1 0 0.0 0.00 1.00000 EYA4
Sitting height 2.45 5 3 6.7 -0.48 0.41638 EYA4 LRRC37A2 MAPT TWIST1 ZNF746
High blood pressure (mother) 1.51 1 0 0.0 0.00 1.00000 C4orf22
Impedance of leg (left) 0.76 2 0 0.0 0.00 1.00000 LRRC37A2 MAPT
Trunk fat mass 1.06 2 0 0.0 0.00 1.00000 LRRC37A2 MAPT
Past tobacco smoking 2.07 2 0 0.0 0.00 1.00000 COMMD7 PCCA
Alcohol usually taken with meals 1.72 1 0 0.0 0.00 1.00000 COMMD7
Nervous feelings 3.06 2 2 4.4 0.00 1.00000 LRRC37A2 MAPT
Frequency of tenseness / restlessness in last 2 weeks 3.82 2 2 4.4 0.00 1.00000 LRRC37A2 MAPT
Hearing difficulty/problems with background noise 1.94 2 0 0.0 0.00 1.00000 LRRC37A2 MAPT
Forced vital capacity (FVC) 5.49 4 3 6.7 -0.73 0.27007 C10orf11 LRRC37A2 MAPT TWIST1
Heel bone mineral density (BMD) T-score, automated (right) 2.39 1 1 2.2 0.00 1.00000 EYA4
Ever unenthusiastic/disinterested for a whole week 2.60 2 0 0.0 0.00 1.00000 LRRC37A2 MAPT
Neuroticism score 4.64 2 2 4.4 0.00 1.00000 LRRC37A2 MAPT
Impedance of arm (right) 1.51 2 2 4.4 0.00 1.00000 LRRC37A2 MAPT
Arm fat percentage (right) 0.69 1 0 0.0 0.00 1.00000 PRRX1
Hip circumference 1.31 2 1 2.2 0.00 1.00000 EYA4 PRRX1
Time employed in main current job 2.81 2 0 0.0 0.00 1.00000 LRRC37A2 MAPT
Worrier / anxious feelings 2.64 2 2 4.4 0.00 1.00000 LRRC37A2 MAPT
Hair/balding pattern: Pattern 3 26.00 10 8 17.8 -0.92 0.00014 C21orf96 C4orf22 EYA4 LRRC37A2 MAPT PCCA PRRX1 RPL41P1 TMEM30B TWIST1
Number of live births 2.39 2 0 0.0 0.00 1.00000 LRRC37A2 MAPT
Forced expiratory volume in 1-second (FEV1) 6.14 3 3 6.7 0.00 1.00000 C10orf11 LRRC37A2 MAPT
Medication: Ibuprofen (e.g. Nurofen) 2.56 2 0 0.0 0.00 1.00000 LRRC37A2 MAPT
Forced expiratory volume in 1-second (FEV1), Best measure 5.80 5 3 6.7 -0.51 0.37901 C10orf11 LRRC37A2 MAPT TWIST1 ZNF746
Impedance of arm (left) 1.69 3 2 4.4 0.00 1.00000 LRRC37A2 MAPT RPL41P1
Standing height 1.00 3 3 6.7 0.00 1.00000 EYA4 LRRC37A2 MAPT
Hair/balding pattern: Pattern 4 35.61 9 9 20.0 -0.69 0.03774 C10orf11 C4orf22 CPEB2 EPC1 LRRC37A2 MAPT PRRX1 RPL41P1 TWIST1
Birth weight of first child 1.73 1 0 0.0 0.00 1.00000 LINC00926
Peak expiratory flow (PEF) 3.74 3 2 4.4 0.00 1.00000 C10orf11 LRRC37A2 MAPT
Medication: Paracetamol 4.43 3 2 4.4 0.00 1.00000 COMMD7 LRRC37A2 MAPT
Headache pain in last month 5.04 2 2 4.4 0.00 1.00000 LRRC37A2 MAPT
Medication for cholesterol, blood pressure or diabetes 1.77 1 0 0.0 0.00 1.00000 C4orf22
Birth weight 1.54 1 0 0.0 0.00 1.00000 CPEB2
Forced vital capacity (FVC), Best measure 5.70 5 3 6.7 -0.49 0.40722 C10orf11 LRRC37A2 MAPT TWIST1 ZNF746
Body fat percentage 1.10 4 0 0.0 -0.01 0.99290 C4orf22 LRRC37A2 MAPT PRRX1
Leg fat percentage (right) 0.93 1 0 0.0 0.00 1.00000 PRRX1
Number of full brothers 1.91 2 0 0.0 0.00 1.00000 LRRC37A2 MAPT
Worry too long after embarrassment 1.73 2 0 0.0 0.00 1.00000 LRRC37A2 MAPT
Age at first live birth 1.74 1 0 0.0 0.00 1.00000 C10orf11
Pulse wave peak to peak time 1.55 1 0 0.0 0.00 1.00000 COMMD7
Qualifications: College or University degree 2.61 3 2 4.4 0.00 1.00000 LRRC37A2 MAPT PCCA
Medication for pain relief, constipation, heartburn 3.25 3 1 2.2 0.00 1.00000 COMMD7 LRRC37A2 MAPT
Neck or shoulder pain in last month 1.65 1 0 0.0 0.00 1.00000 COMMD7
Medication: Blood pressure 1.99 1 1 2.2 0.00 1.00000 C4orf22
Pulse rate, automated reading 1.04 2 0 0.0 0.00 1.00000 C4orf22 EYA4
Alcohol intake frequency. 2.57 2 2 4.4 0.00 1.00000 LRRC37A2 MAPT
Comparative height size at age 10 1.18 3 2 4.4 0.00 1.00000 C4orf22 LRRC37A2 MAPT
Overall health rating 1.28 1 0 0.0 0.00 1.00000 COMMD7
Supplements: Vitamin C 2.23 2 0 0.0 0.00 1.00000 LRRC37A2 MAPT
Hypertension (Self-reported) 2.98 1 1 2.2 0.00 1.00000 C4orf22
Illnesses of father: Heart disease 1.55 1 0 0.0 0.00 1.00000 MAPT
Smoking status: Previous 2.53 2 0 0.0 0.00 1.00000 COMMD7 PCCA
Arm fat percentage (left) 0.74 1 0 0.0 0.00 1.00000 PRRX1
Handedness (chirality/laterality): Left-handed 4.12 2 2 4.4 0.00 1.00000 LRRC37A2 MAPT
Mood swings 4.43 2 2 4.4 0.00 1.00000 LRRC37A2 MAPT
Loneliness, isolation 1.97 2 0 0.0 0.00 1.00000 LRRC37A2 MAPT
Long-standing illness, disability or infirmity 1.33 1 0 0.0 0.00 1.00000 COMMD7
Mouth/teeth dental problems: Mouth ulcers 3.56 2 2 4.4 0.00 1.00000 LRRC37A2 MAPT
Medication for cholesterol 2.57 1 0 0.0 0.00 1.00000 C4orf22
Asthma (self-reported) 0.87 1 0 0.0 0.00 1.00000 EPC1
Forced expiratory volume in 1-second (FEV1), predicted percentage 6.07 5 2 4.4 -0.75 0.14799 C10orf11 EPC1 LRRC37A2 MAPT PRRX1
Average weekly champagne plus white wine intake 2.49 2 0 0.0 0.00 1.00000 LRRC37A2 MAPT
Miserableness 2.55 2 2 4.4 0.00 1.00000 LRRC37A2 MAPT
Guilty feelings 2.88 2 0 0.0 0.00 1.00000 LRRC37A2 MAPT
Commuting to job workplace: Public transport 1.97 1 0 0.0 0.00 1.00000 C21orf96
Medication: Blood pressure 3.41 3 1 2.2 0.00 1.00000 C4orf22 LRRC37A2 MAPT
Medication: Paracetamol 4.44 3 2 4.4 0.00 1.00000 COMMD7 LRRC37A2 MAPT
Medication: Lisinopril 1.42 1 0 0.0 0.00 1.00000 C4orf22
Illnesses of father: High blood pressure 1.98 1 0 0.0 0.00 1.00000 C4orf22
Ever smoked 1.52 1 0 0.0 0.00 1.00000 PCCA
Leg fat percentage (left) 0.86 1 0 0.0 0.00 1.00000 PRRX1
Irritability 3.23 2 2 4.4 0.00 1.00000 LRRC37A2 MAPT
Fractured/broken bones in last 5 years 2.37 2 0 0.0 0.00 1.00000 LRRC37A2 MAPT
Diastolic blood pressure, automated reading 1.52 1 1 2.2 0.00 1.00000 C4orf22
Ever depressed for a whole week 2.24 2 0 0.0 0.00 1.00000 LRRC37A2 MAPT
Myopia 2.74 3 0 0.0 0.00 1.00000 LRRC37A2 MAPT PCCA
Vascular/heart problems diagnosed by doctor 2.79 1 1 2.2 0.00 1.00000 C4orf22
Pain experienced in last month 1.67 1 0 0.0 0.00 1.00000 COMMD7
Impedance of whole body 1.30 2 2 4.4 0.00 1.00000 LRRC37A2 MAPT

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.029 1.2
GTEx Adipose Visceral Omentum 2 0.098 1.3
GTEx Adrenal Gland 1 0.069 1.3
GTEx Artery Aorta 3 0.101 1.3
GTEx Artery Coronary 3 0.254 1.3
GTEx Artery Tibial 1 0.027 1.2
GTEx Brain Caudate basal ganglia 2 0.217 1.3
GTEx Brain Cerebellar Hemisphere 2 0.134 1.4
GTEx Brain Cerebellum 3 0.151 1.3
GTEx Brain Cortex 2 0.193 1.4
GTEx Brain Frontal Cortex BA9 2 0.216 1.4
GTEx Brain Hippocampus 1 0.191 1.5
GTEx Brain Hypothalamus 1 0.169 1.4
GTEx Brain Nucleus accumbens basal ganglia 2 0.231 1.4
GTEx Brain Putamen basal ganglia 1 0.160 1.3
GTEx Breast Mammary Tissue 2 0.101 1.3
GTEx Breast Mammary Tissue (Male) 2 0.168 1.4
GTEx Breast Mammary Tissue (Female) 2 0.122 1.3
GTEx Cells EBV-transformed lymphocytes 2 0.141 1.4
GTEx Cells Transformed fibroblasts 4 0.095 1.3
GTEx Colon Sigmoid 1 0.068 1.3
GTEx Colon Transverse 4 0.194 1.4
GTEx Esophagus Gastroesophageal Junction 3 0.208 1.4
GTEx Esophagus Mucosa 3 0.090 1.3
GTEx Esophagus Muscularis 2 0.062 1.3
GTEx Heart Atrial Appendage 2 0.127 1.3
GTEx Heart Left Ventricle 1 0.065 1.3
GTEx Liver 1 0.139 1.4
GTEx Lung 2 0.070 1.3
GTEx Muscle Skeletal 2 0.069 1.3
GTEx Nerve Tibial 4 0.093 1.3
GTEx Ovary 2 0.220 1.4
GTEx Pancreas 2 0.123 1.4
GTEx Pituitary 1 0.090 1.3
GTEx Prostate 1 0.120 1.4
GTEx Skin Not Sun Exposed Suprapubic 3 0.122 1.3
GTEx Skin Sun Exposed Lower leg 2 0.055 1.3
GTEx Small Intestine Terminal Ileum 1 0.217 1.4
GTEx Spleen 3 0.213 1.3
GTEx Stomach 3 0.206 1.4
GTEx Testis 3 0.095 1.3
GTEx Thyroid 3 0.075 1.3
GTEx Uterus 1 0.176 1.4
GTEx Vagina 4 0.630 1.6
GTEx Whole Blood 1 0.050 1.2
METSIM Adipose 0 0.000 1.2
NTR Blood 1 0.042 1.3
ROSMAP Brain Pre-frontal Cortex 1 0.023 1.2
YFS Blood 2 0.043 1.2
CommonMind Brain Pre-frontal Cortex 4 0.074 1.3
The Cancer Genome Atlas Bladder Urothelial Carcinoma 2 0.121 1.2
The Cancer Genome Atlas Breast Invasive Carcinoma 2 0.045 1.2
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 3 0.273 1.3
The Cancer Genome Atlas Colon Adenocarcinoma 2 0.097 1.3
The Cancer Genome Atlas Esophageal Carcinoma 3 0.438 1.3
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.3
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 1 0.037 1.2
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 6 0.146 1.2
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 2 0.098 1.2
The Cancer Genome Atlas Brain Lower Grade Glioma 3 0.070 1.2
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 1 0.090 1.2
The Cancer Genome Atlas Lung Adenocarcinoma 4 0.136 1.3
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 3 0.120 1.2
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 2 0.126 1.3
The Cancer Genome Atlas Pancreatic Adenocarcinoma 3 0.181 1.3
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 4 0.301 1.3
The Cancer Genome Atlas Prostate Adenocarcinoma 5 0.108 1.3
The Cancer Genome Atlas Rectum Adenocarcinoma 1 0.145 1.3
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.3
The Cancer Genome Atlas Skin Cutaneous Melanoma 1 0.187 1.2
The Cancer Genome Atlas Stomach Adenocarcinoma 2 0.119 1.3
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.2
The Cancer Genome Atlas Thyroid Carcinoma 3 0.058 1.2
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 2 0.394 1.4