Hub : Traits :

Hair/balding pattern: Pattern 2

157 significantly associated models · 35 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	169191860	171407761	2	1	2.0e-09	1.7e-14	5.1e-13	11	PRRX1
2	4	14310407	16125136	2	1	2.0e-12	6.2e-11	2.6e-01	97	CPEB2
3	4	80488345	82578407	2	1	2.3e-12	1.9e-12	1.0e+00	100	C4orf22
4	6	133319409	134100937	1	1	9.9e-08	4.4e-08	7.3e-03	76	EYA4
5	7	18364750	19854141	1	1	1.4e-11	7.6e-18	6.4e-08	60	TWIST1
6	7	148480233	149855335	1	1	7.4e-08	7.8e-08	3.0e-01	96	ZNF746
7	10	31857752	33353843	1	1	1.4e-08	5.2e-10	6.6e-03	81	EPC1
8	10	76664253	79018276	1	1	7.7e-08	3.7e-09	1.2e-02	82	C10orf11
9	13	100044673	101879559	1	1	1.3e-08	7.2e-11	7.4e-06	53	PCCA
10	14	61505657	61992400	1	1	4.8e-11	1.8e-11	4.4e-09	24	TMEM30B
11	15	56896007	58298129	2	1	2.3e-10	8.1e-09	1.8e-01	94	LINC00926
12	17	42607368	43913030	5	1	8.2e-10	1.4e-06	1.6e-02	75	MAPT
13	17	44788310	45796313	4	1	5.1e-10	7.6e-10	1.0e+00	100	LRRC37A2
14	17	62973790	64251733	1	1	1.8e-12	1.0e-12	1.0e+00	100	AXIN2
15	20	21043102	22430527	1	1	4.2e-12	1.6e-25	2.7e-15	43	RPL41P1
16	20	30591354	32083711	2	1	3.6e-08	1.9e-07	7.2e-01	100	COMMD7
17	21	36163513	36656310	1	1	1.5e-17	2.0e-23	3.2e-08	69	C21orf96

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Hair/balding pattern: Pattern 4	35.61	9	9	20.0	-0.69	0.03774	C10orf11 C4orf22 CPEB2 EPC1 LRRC37A2 MAPT PRRX1 RPL41P1 TWIST1
Hair/balding pattern: Pattern 3	26.00	10	8	17.8	-0.92	0.00014	C21orf96 C4orf22 EYA4 LRRC37A2 MAPT PCCA PRRX1 RPL41P1 TMEM30B TWIST1
Relative age of first facial hair	8.14	4	3	6.7	0.94	0.06083	C4orf22 LRRC37A2 MAPT TWIST1
Lung FVC	6.84	4	4	8.9	-0.72	0.27884	C10orf11 LRRC37A2 MAPT TWIST1
Forced expiratory volume in 1-second (FEV1)	6.14	3	3	6.7	0.00	1.00000	C10orf11 LRRC37A2 MAPT
Forced expiratory volume in 1-second (FEV1), predicted percentage	6.07	5	2	4.4	-0.75	0.14799	C10orf11 EPC1 LRRC37A2 MAPT PRRX1
Blood Red Count	5.82	3	2	4.4	0.00	1.00000	C4orf22 LRRC37A2 MAPT
Forced expiratory volume in 1-second (FEV1), Best measure	5.80	5	3	6.7	-0.51	0.37901	C10orf11 LRRC37A2 MAPT TWIST1 ZNF746
Forced vital capacity (FVC), Best measure	5.70	5	3	6.7	-0.49	0.40722	C10orf11 LRRC37A2 MAPT TWIST1 ZNF746
Neuroticism (Nagel 2018)	5.62	2	2	4.4	0.00	1.00000	LRRC37A2 MAPT
Forced vital capacity (FVC)	5.49	4	3	6.7	-0.73	0.27007	C10orf11 LRRC37A2 MAPT TWIST1
Neuroticism	5.38	2	2	4.4	0.00	1.00000	LRRC37A2 MAPT
Sensitivity / hurt feelings	5.30	2	2	4.4	0.00	1.00000	LRRC37A2 MAPT
Headache pain in last month	5.04	2	2	4.4	0.00	1.00000	LRRC37A2 MAPT
Depressed Affect (Nagel 2018)	4.79	2	2	4.4	0.00	1.00000	LRRC37A2 MAPT
Relative age voice broke	4.78	2	2	4.4	0.00	1.00000	LRRC37A2 MAPT
Ovarian Cancer	4.77	2	2	4.4	0.00	1.00000	LRRC37A2 MAPT
Waist Hip Ratio (WHR)	4.69	5	4	8.9	-0.03	0.96662	AXIN2 EPC1 LRRC37A2 MAPT PRRX1
Neuroticism score	4.64	2	2	4.4	0.00	1.00000	LRRC37A2 MAPT
Medication: Paracetamol	4.44	3	2	4.4	0.00	1.00000	COMMD7 LRRC37A2 MAPT
Medication: Paracetamol	4.43	3	2	4.4	0.00	1.00000	COMMD7 LRRC37A2 MAPT
Mood swings	4.43	2	2	4.4	0.00	1.00000	LRRC37A2 MAPT
Handedness (chirality/laterality): Left-handed	4.12	2	2	4.4	0.00	1.00000	LRRC37A2 MAPT
Frequency of tenseness / restlessness in last 2 weeks	3.82	2	2	4.4	0.00	1.00000	LRRC37A2 MAPT
Peak expiratory flow (PEF)	3.74	3	2	4.4	0.00	1.00000	C10orf11 LRRC37A2 MAPT
Worry (Nagel 2018)	3.63	2	2	4.4	0.00	1.00000	LRRC37A2 MAPT
Heel T-Score	3.57	6	5	11.1	-0.19	0.71266	CPEB2 EYA4 LRRC37A2 MAPT PRRX1 TWIST1
Mouth/teeth dental problems: Mouth ulcers	3.56	2	2	4.4	0.00	1.00000	LRRC37A2 MAPT
Systolic Blood Pressure	3.45	5	2	4.4	-0.86	0.06300	C4orf22 COMMD7 CPEB2 LRRC37A2 MAPT
Medication: Blood pressure	3.41	3	1	2.2	0.00	1.00000	C4orf22 LRRC37A2 MAPT
Medication for pain relief, constipation, heartburn	3.25	3	1	2.2	0.00	1.00000	COMMD7 LRRC37A2 MAPT
Irritability	3.23	2	2	4.4	0.00	1.00000	LRRC37A2 MAPT
Blood Eosinophil Count	3.14	3	3	6.7	0.00	1.00000	C21orf96 LRRC37A2 MAPT
Fed-up feelings	3.12	2	2	4.4	0.00	1.00000	LRRC37A2 MAPT
Nervous feelings	3.06	2	2	4.4	0.00	1.00000	LRRC37A2 MAPT
High blood pressure	3.03	3	1	2.2	0.00	1.00000	C4orf22 LRRC37A2 MAPT
Systolic blood pressure, automated reading	3.01	3	1	2.2	0.00	1.00000	C4orf22 LRRC37A2 MAPT
Hypertension (Self-reported)	2.98	1	1	2.2	0.00	1.00000	C4orf22
Hand grip strength (left)	2.92	3	2	4.4	0.00	1.00000	LINC00926 LRRC37A2 MAPT
Guilty feelings	2.88	2	0	0.0	0.00	1.00000	LRRC37A2 MAPT
Time employed in main current job	2.81	2	0	0.0	0.00	1.00000	LRRC37A2 MAPT
Vascular/heart problems diagnosed by doctor	2.79	1	1	2.2	0.00	1.00000	C4orf22
Myopia	2.74	3	0	0.0	0.00	1.00000	LRRC37A2 MAPT PCCA
Qualifications: CSEs or equivalent	2.69	2	0	0.0	0.00	1.00000	LRRC37A2 MAPT
Worrier / anxious feelings	2.64	2	2	4.4	0.00	1.00000	LRRC37A2 MAPT
Cardiovascular Disease	2.62	1	1	2.2	0.00	1.00000	C4orf22
Qualifications: College or University degree	2.61	3	2	4.4	0.00	1.00000	LRRC37A2 MAPT PCCA
Ever unenthusiastic/disinterested for a whole week	2.60	2	0	0.0	0.00	1.00000	LRRC37A2 MAPT
Alcohol intake frequency.	2.57	2	2	4.4	0.00	1.00000	LRRC37A2 MAPT
Medication for cholesterol	2.57	1	0	0.0	0.00	1.00000	C4orf22
Medication: Ibuprofen (e.g. Nurofen)	2.56	2	0	0.0	0.00	1.00000	LRRC37A2 MAPT
Miserableness	2.55	2	2	4.4	0.00	1.00000	LRRC37A2 MAPT
Smoking status: Previous	2.53	2	0	0.0	0.00	1.00000	COMMD7 PCCA
Average weekly champagne plus white wine intake	2.49	2	0	0.0	0.00	1.00000	LRRC37A2 MAPT
Sitting height	2.45	5	3	6.7	-0.48	0.41638	EYA4 LRRC37A2 MAPT TWIST1 ZNF746
Heel bone mineral density (BMD) T-score, automated (right)	2.39	1	1	2.2	0.00	1.00000	EYA4
Number of live births	2.39	2	0	0.0	0.00	1.00000	LRRC37A2 MAPT
Fractured/broken bones in last 5 years	2.37	2	0	0.0	0.00	1.00000	LRRC37A2 MAPT
Neuroticism (2016)	2.33	2	0	0.0	0.00	1.00000	LRRC37A2 MAPT
Heel bone mineral density (BMD) T-score, automated (left)	2.30	1	1	2.2	0.00	1.00000	EYA4
Ever depressed for a whole week	2.24	2	0	0.0	0.00	1.00000	LRRC37A2 MAPT
Supplements: Vitamin C	2.23	2	0	0.0	0.00	1.00000	LRRC37A2 MAPT
Vitamin and mineral supplements	2.18	1	0	0.0	0.00	1.00000	LRRC37A2
Hand grip strength (right)	2.18	2	2	4.4	0.00	1.00000	LRRC37A2 MAPT
Crohns Disease (2012)	2.11	1	0	0.0	0.00	1.00000	ZNF746
Past tobacco smoking	2.07	2	0	0.0	0.00	1.00000	COMMD7 PCCA
Primary Biliary Cirrhosis	2.03	2	0	0.0	0.00	1.00000	LRRC37A2 MAPT
Breast Cancer	2.02	2	0	0.0	0.00	1.00000	LRRC37A2 MAPT
Frequency of depressed mood in last 2 weeks	2.02	2	0	0.0	0.00	1.00000	LRRC37A2 MAPT
Mean Putamen Volume	2.01	2	0	0.0	0.00	1.00000	LRRC37A2 MAPT
Medication: Blood pressure	1.99	1	1	2.2	0.00	1.00000	C4orf22
Illnesses of father: High blood pressure	1.98	1	0	0.0	0.00	1.00000	C4orf22
Loneliness, isolation	1.97	2	0	0.0	0.00	1.00000	LRRC37A2 MAPT
Commuting to job workplace: Public transport	1.97	1	0	0.0	0.00	1.00000	C21orf96
Hearing difficulty/problems with background noise	1.94	2	0	0.0	0.00	1.00000	LRRC37A2 MAPT
Number of full brothers	1.91	2	0	0.0	0.00	1.00000	LRRC37A2 MAPT
Depression (Nagel 2018)	1.77	2	0	0.0	0.00	1.00000	LRRC37A2 MAPT
Medication for cholesterol, blood pressure or diabetes	1.77	1	0	0.0	0.00	1.00000	C4orf22
Lung FEV1/FVC ratio	1.76	4	1	2.2	-0.59	0.41208	C10orf11 EYA4 LRRC37A2 MAPT
Age at first live birth	1.74	1	0	0.0	0.00	1.00000	C10orf11
Birth weight of first child	1.73	1	0	0.0	0.00	1.00000	LINC00926
Worry too long after embarrassment	1.73	2	0	0.0	0.00	1.00000	LRRC37A2 MAPT
Alcohol usually taken with meals	1.72	1	0	0.0	0.00	1.00000	COMMD7
Impedance of arm (left)	1.69	3	2	4.4	0.00	1.00000	LRRC37A2 MAPT RPL41P1
Pain experienced in last month	1.67	1	0	0.0	0.00	1.00000	COMMD7
Neck or shoulder pain in last month	1.65	1	0	0.0	0.00	1.00000	COMMD7
Smoking Status	1.63	3	0	0.0	0.00	1.00000	LRRC37A2 MAPT PCCA
Pulse wave peak to peak time	1.55	1	0	0.0	0.00	1.00000	COMMD7
Illnesses of father: Heart disease	1.55	1	0	0.0	0.00	1.00000	MAPT
Medication: Levothyroxine sodium	1.54	1	0	0.0	0.00	1.00000	EYA4
Birth weight	1.54	1	0	0.0	0.00	1.00000	CPEB2
Ever smoked	1.52	1	0	0.0	0.00	1.00000	PCCA
Diastolic blood pressure, automated reading	1.52	1	1	2.2	0.00	1.00000	C4orf22
High blood pressure (mother)	1.51	1	0	0.0	0.00	1.00000	C4orf22
Impedance of arm (right)	1.51	2	2	4.4	0.00	1.00000	LRRC37A2 MAPT
Medication: Atenolol	1.47	1	0	0.0	0.00	1.00000	C4orf22
Trunk fat percentage	1.44	3	2	4.4	0.00	1.00000	LRRC37A2 MAPT PRRX1
Intelligence (Savage-Jansen 2018)	1.42	2	0	0.0	0.00	1.00000	LRRC37A2 MAPT
Medication: Lisinopril	1.42	1	0	0.0	0.00	1.00000	C4orf22
Height	1.33	8	4	8.9	-0.47	0.23943	AXIN2 C10orf11 EPC1 EYA4 LRRC37A2 MAPT RPL41P1 ZNF746
Long-standing illness, disability or infirmity	1.33	1	0	0.0	0.00	1.00000	COMMD7
Hip circumference	1.31	2	1	2.2	0.00	1.00000	EYA4 PRRX1
Reaction Time	1.30	1	0	0.0	0.00	1.00000	COMMD7
Impedance of whole body	1.30	2	2	4.4	0.00	1.00000	LRRC37A2 MAPT
Overall health rating	1.28	1	0	0.0	0.00	1.00000	COMMD7
Number of treatments/medications taken	1.27	1	0	0.0	0.00	1.00000	COMMD7
Respiratory disease	1.22	1	0	0.0	0.00	1.00000	EPC1
Comparative height size at age 10	1.18	3	2	4.4	0.00	1.00000	C4orf22 LRRC37A2 MAPT
Schizophrenia (2014)	1.11	1	0	0.0	0.00	1.00000	LRRC37A2
Body fat percentage	1.10	4	0	0.0	-0.01	0.99290	C4orf22 LRRC37A2 MAPT PRRX1
Blood Platelet Count	1.08	6	2	4.4	0.67	0.14687	C21orf96 COMMD7 CPEB2 LINC00926 LRRC37A2 MAPT
Serious illness, injury or assault to yourself	1.08	1	0	0.0	0.00	1.00000	COMMD7
Trunk fat mass	1.06	2	0	0.0	0.00	1.00000	LRRC37A2 MAPT
Pulse rate, automated reading	1.04	2	0	0.0	0.00	1.00000	C4orf22 EYA4
Standing height	1.00	3	3	6.7	0.00	1.00000	EYA4 LRRC37A2 MAPT
Leg fat percentage (right)	0.93	1	0	0.0	0.00	1.00000	PRRX1
Asthma (self-reported)	0.87	1	0	0.0	0.00	1.00000	EPC1
Leg fat percentage (left)	0.86	1	0	0.0	0.00	1.00000	PRRX1
Hair Pigment	0.79	8	5	11.1	-0.47	0.23803	AXIN2 C4orf22 COMMD7 EPC1 LRRC37A2 MAPT RPL41P1 TWIST1
Impedance of leg (left)	0.76	2	0	0.0	0.00	1.00000	LRRC37A2 MAPT
Arm fat percentage (left)	0.74	1	0	0.0	0.00	1.00000	PRRX1
Blood White Count	0.73	4	0	0.0	0.60	0.40049	EPC1 EYA4 LRRC37A2 MAPT
Impedance of leg (right)	0.69	2	0	0.0	0.00	1.00000	LRRC37A2 MAPT
Arm fat percentage (right)	0.69	1	0	0.0	0.00	1.00000	PRRX1
Tanning	0.54	1	1	2.2	0.00	1.00000	COMMD7
BMI	0.47	1	0	0.0	0.00	1.00000	C4orf22

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Vagina	4	0.630	1.6
GTEx	Brain Hippocampus	1	0.191	1.5
GTEx	Brain Cerebellar Hemisphere	2	0.134	1.4
GTEx	Brain Cortex	2	0.193	1.4
GTEx	Brain Frontal Cortex BA9	2	0.216	1.4
GTEx	Brain Hypothalamus	1	0.169	1.4
GTEx	Brain Nucleus accumbens basal ganglia	2	0.231	1.4
GTEx	Breast Mammary Tissue (Male)	2	0.168	1.4
GTEx	Cells EBV-transformed lymphocytes	2	0.141	1.4
GTEx	Colon Transverse	4	0.194	1.4
GTEx	Esophagus Gastroesophageal Junction	3	0.208	1.4
GTEx	Liver	1	0.139	1.4
GTEx	Ovary	2	0.220	1.4
GTEx	Pancreas	2	0.123	1.4
GTEx	Prostate	1	0.120	1.4
GTEx	Small Intestine Terminal Ileum	1	0.217	1.4
GTEx	Stomach	3	0.206	1.4
GTEx	Uterus	1	0.176	1.4
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	2	0.394	1.4
GTEx	Adipose Visceral Omentum	2	0.098	1.3
GTEx	Adrenal Gland	1	0.069	1.3
GTEx	Artery Aorta	3	0.101	1.3
GTEx	Artery Coronary	3	0.254	1.3
GTEx	Brain Caudate basal ganglia	2	0.217	1.3
GTEx	Brain Cerebellum	3	0.151	1.3
GTEx	Brain Putamen basal ganglia	1	0.160	1.3
GTEx	Breast Mammary Tissue	2	0.101	1.3
GTEx	Breast Mammary Tissue (Female)	2	0.122	1.3
GTEx	Cells Transformed fibroblasts	4	0.095	1.3
GTEx	Colon Sigmoid	1	0.068	1.3
GTEx	Esophagus Mucosa	3	0.090	1.3
GTEx	Esophagus Muscularis	2	0.062	1.3
GTEx	Heart Atrial Appendage	2	0.127	1.3
GTEx	Heart Left Ventricle	1	0.065	1.3
GTEx	Lung	2	0.070	1.3
GTEx	Muscle Skeletal	2	0.069	1.3
GTEx	Nerve Tibial	4	0.093	1.3
GTEx	Pituitary	1	0.090	1.3
GTEx	Skin Not Sun Exposed Suprapubic	3	0.122	1.3
GTEx	Skin Sun Exposed Lower leg	2	0.055	1.3
GTEx	Spleen	3	0.213	1.3
GTEx	Testis	3	0.095	1.3
GTEx	Thyroid	3	0.075	1.3
NTR	Blood	1	0.042	1.3
CommonMind	Brain Pre-frontal Cortex	4	0.074	1.3
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	3	0.273	1.3
The Cancer Genome Atlas	Colon Adenocarcinoma	2	0.097	1.3
The Cancer Genome Atlas	Esophageal Carcinoma	3	0.438	1.3
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.3
The Cancer Genome Atlas	Lung Adenocarcinoma	4	0.136	1.3
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	2	0.126	1.3
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	3	0.181	1.3
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	4	0.301	1.3
The Cancer Genome Atlas	Prostate Adenocarcinoma	5	0.108	1.3
The Cancer Genome Atlas	Rectum Adenocarcinoma	1	0.145	1.3
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.3
The Cancer Genome Atlas	Stomach Adenocarcinoma	2	0.119	1.3
GTEx	Adipose Subcutaneous	1	0.029	1.2
GTEx	Artery Tibial	1	0.027	1.2
GTEx	Whole Blood	1	0.050	1.2
METSIM	Adipose	0	0.000	1.2
ROSMAP	Brain Pre-frontal Cortex	1	0.023	1.2
YFS	Blood	2	0.043	1.2
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	2	0.121	1.2
The Cancer Genome Atlas	Breast Invasive Carcinoma	2	0.045	1.2
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	1	0.037	1.2
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	6	0.146	1.2
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	2	0.098	1.2
The Cancer Genome Atlas	Brain Lower Grade Glioma	3	0.070	1.2
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	1	0.090	1.2
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	3	0.120	1.2
The Cancer Genome Atlas	Skin Cutaneous Melanoma	1	0.187	1.2
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.2
The Cancer Genome Atlas	Thyroid Carcinoma	3	0.058	1.2