TWAS
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Traits
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Traits
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Forced vital capacity (FVC)
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chr5:121,480,516-123,002,130
Best TWAS P=7.64e-10 · Best GWAS P=4.45e-13 conditioned to 0.00102
121.4M
121.6M
121.8M
122M
122.2M
122.4M
122.6M
122.8M
123M
0
2
4
6
8
10
12
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Artery Aorta
CTB-36H16.2
0.12
0.15
lasso
3
0.12
2.6e-07
-6.2
6.2
7.6e-10
-0.05
0.00
1.00
TRUE
4
The Cancer Genome Atlas
Prostate Adenocarcinoma
CEP120
0.10
0.14
blup
70
0.14
2.6e-14
-7.0
6.1
9.0e-10
-0.83
0.02
0.98
TRUE
2
GTEx
Artery Tibial
CTB-36H16.2
0.15
0.12
lasso
6
0.09
8.1e-08
-5.5
5.5
3.1e-08
0.02
0.15
0.85
FALSE
3
GTEx
Esophagus Muscularis
CTB-36H16.2
0.08
0.08
lasso
2
0.04
1.5e-03
-5.5
5.5
3.1e-08
0.02
0.08
0.82
FALSE