Best TWAS P=3.11e-16 · Best GWAS P=8.43e-17 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | CTA-85E5.10 | 0.10 | 0.04 | lasso | 9 | 0.03 | 1.9e-03 | 7.42 | -8.2 | 3.1e-16 | -0.96 | 0.01 | 0.98 | TRUE |
| 2 | GTEx | Adipose Visceral Omentum | MTMR3 | 0.22 | 0.11 | enet | 17 | 0.10 | 1.1e-05 | -4.92 | -5.1 | 2.8e-07 | -0.19 | 1.00 | 0.00 | TRUE |
| 3 | GTEx | Breast Mammary Tissue | MTMR3 | 0.33 | 0.26 | lasso | 6 | 0.29 | 2.0e-15 | -4.94 | -5.2 | 2.2e-07 | -0.15 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Lung | MTMR3 | 0.15 | 0.07 | lasso | 5 | 0.11 | 1.7e-08 | -4.45 | -5.2 | 2.6e-07 | -0.17 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Lung | CTA-85E5.10 | 0.09 | 0.01 | enet | 16 | 0.02 | 2.3e-02 | -4.89 | -6.0 | 2.2e-09 | -0.52 | 0.06 | 0.55 | TRUE |
| 6 | GTEx | Muscle Skeletal | MTMR3 | 0.07 | 0.04 | lasso | 3 | 0.03 | 5.5e-04 | -4.94 | -5.3 | 1.5e-07 | -0.20 | 0.71 | 0.01 | FALSE |
| 7 | GTEx | Prostate | MTMR3 | 0.62 | 0.29 | lasso | 14 | 0.24 | 9.3e-07 | -4.94 | -5.4 | 8.1e-08 | -0.19 | 0.92 | 0.01 | TRUE |
| 8 | GTEx | Testis | MTMR3 | 0.27 | 0.17 | enet | 13 | 0.26 | 8.9e-12 | -3.55 | -5.3 | 1.2e-07 | -0.25 | 1.00 | 0.00 | TRUE |
| 9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ASCC2 | 0.04 | 0.00 | blup | 48 | 0.01 | 1.1e-02 | 0.13 | -5.9 | 4.6e-09 | -0.57 | 0.01 | 0.62 | TRUE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | HORMAD2 | 0.06 | 0.04 | enet | 10 | 0.07 | 5.7e-07 | 5.21 | -5.5 | 3.9e-08 | -0.42 | 0.99 | 0.01 | FALSE |
| 11 | The Cancer Genome Atlas | Thyroid Carcinoma | MTMR3 | 0.21 | 0.08 | blup | 72 | 0.16 | 2.5e-15 | 5.38 | -5.3 | 1.3e-07 | -0.22 | 1.00 | 0.00 | FALSE |