Hub : Genes

ASCC2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.1320 0.0530 3.3e-03 -0.005 NA -0.005 NA -0.004 9.0e-01 NA 9.2e-01 NA 6.1e-01
2 GTEx Artery Tibial 0.1523 0.0629 1.3e-03 0.098 NA 0.093 NA 0.098 4.5e-08 NA 9.7e-08 NA 4.3e-08
3 GTEx Brain Cerebellum 0.2460 0.0800 3.7e-04 0.202 NA 0.118 NA 0.196 1.3e-06 NA 2.4e-04 NA 1.9e-06
4 GTEx Cells Transformed fibroblasts 0.0510 0.0260 5.4e-03 0.048 NA 0.034 NA 0.038 1.6e-04 NA 1.3e-03 NA 6.8e-04
5 GTEx Nerve Tibial 0.1736 0.0620 1.1e-04 0.069 NA 0.077 NA 0.080 1.3e-05 NA 4.1e-06 NA 2.6e-06
6 GTEx Testis 0.2770 0.0610 7.2e-14 0.305 NA 0.297 NA 0.365 4.8e-14 NA 1.2e-13 NA 4.1e-17
7 GTEx Thyroid 0.1060 0.0390 9.8e-05 0.038 NA 0.032 NA 0.053 6.5e-04 NA 1.5e-03 NA 6.4e-05
8 GTEx Whole Blood 0.1140 0.0490 1.7e-04 0.029 NA 0.033 NA 0.030 9.6e-04 NA 4.4e-04 NA 8.5e-04
9 NTR Blood 0.0442 0.0177 1.3e-04 -0.001 0.013 0.012 0.012 0.002 8.2e-01 4.5e-05 8.4e-05 6.4e-05 6.1e-02
10 YFS Blood 0.3503 0.0408 0.0e+00 0.144 0.240 0.270 0.251 0.260 8.9e-45 1.5e-77 2.0e-88 2.0e-81 9.6e-85
11 TCGA Cervical Squamous Cell Carcinoma 0.0730 0.0480 7.5e-03 0.074 0.047 0.070 NA 0.066 1.6e-04 2.5e-03 2.5e-04 NA 3.6e-04
12 TCGA Brain Lower Grade Glioma 0.0413 0.0243 2.5e-03 -0.001 0.013 0.012 NA 0.002 4.1e-01 1.1e-02 1.6e-02 NA 1.6e-01
13 TCGA Prostate Adenocarcinoma 0.0359 0.0196 9.0e-04 0.016 0.027 0.028 NA 0.024 7.7e-03 7.5e-04 5.9e-04 NA 1.4e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bipolar Disorder (2018) 2.5 3.9 8.0 -1.7 -2.8 -2.6 0.4 -2.1 -1.0 -1.6 -1.5 -2.7 -2.5 -0.1 -2.6 -1.5
Bipolar Disorder or Schizophrenia 1.8 4.3 10.5 -1.3 -2.4 -3.2 1.4 -1.4 -1.8 -1.2 -2.7 -2.8 -2.7 1.0 -2.4 -0.5
Depressed Affect (Nagel 2018) 4.0 8.4 20.4 1.2 1.3 4.2 -3.5 0.4 4.5 -1.1 2.9 3.4 4.2 -2.6 1.2 -3.0
Depression (Nagel 2018) 0.8 1.2 2.9 -0.0 0.5 1.4 -0.5 0.7 1.7 1.3 1.2 0.3 1.4 0.5 1.7 -1.0
Intelligence (Savage-Jansen 2018) 0.7 2.1 4.3 -2.0 -2.1 -1.1 -0.1 -1.6 0.2 -0.5 -0.9 -2.1 -2.0 -0.7 -2.1 -1.1
Neuroticism (Nagel 2018) 2.0 4.8 15.4 -0.3 -0.1 2.9 -2.3 -1.3 3.9 -0.4 1.2 2.8 3.1 -1.7 0.9 -3.0
Schizophrenia (2018) 0.9 1.8 6.4 -0.3 -0.8 -2.0 1.5 -0.1 -1.6 -0.3 -2.5 -1.4 -1.4 1.3 -1.0 0.6
Schizophrenia vs Biploar Disorder 0.1 0.1 0.5 -0.3 0.0 0.2 0.1 -0.0 -0.0 -0.7 -0.4 -0.1 -0.3 0.1 -0.3 0.1
Worry (Nagel 2018) 1.1 2.2 8.4 -2.0 -1.2 1.0 -1.1 -2.0 2.6 -0.5 0.0 0.7 1.1 -0.7 -0.0 -2.9
Alzheimer’s Disease (in mother) 0.3 0.4 1.8 -0.3 -0.7 -0.7 -0.2 -0.6 -0.2 -0.8 -0.6 -0.4 -0.5 -0.3 -1.3 -0.7
Alzheimer’s Disease (in father) 0.6 0.6 1.6 1.0 1.3 -0.3 -0.2 1.2 -1.1 1.0 -0.5 -0.4 -0.1 0.1 -0.3 1.1
Alzheimer’s Disease (including proxy) 0.5 0.8 2.2 0.1 0.2 -1.2 0.1 0.2 -1.5 -0.4 -1.4 -0.9 -0.9 0.1 -1.5 0.4
Crohns Disease (2017) 0.7 1.5 3.4 0.5 -1.2 -1.8 1.4 -0.1 -1.8 -1.8 0.6 -1.2 -1.4 0.8 -0.7 0.9
Irritable Bowel Disease (IBD) 1.5 3.7 11.2 1.5 -0.1 -2.1 3.3 1.5 -2.8 -0.9 0.4 -1.8 -1.1 2.7 1.6 2.1
Ulcerative Colitis (UC) 2.2 4.2 14.3 1.3 0.5 -1.7 3.8 1.8 -2.7 -0.0 -0.0 -1.4 -0.7 3.3 2.5 2.1
Major Depression (MDD) 0.5 0.6 2.3 0.8 -0.1 0.8 -1.5 0.1 0.8 0.3 1.3 -0.4 0.1 -1.1 -0.2 -0.5
Reaction Time 2.0 3.9 10.8 -3.1 -2.9 -1.2 -0.8 -3.3 0.8 -1.7 -0.2 -0.2 -2.0 -1.2 -2.5 -1.9
Verbal and Numeric Reasoning (VNR) 0.5 1.2 3.9 -1.2 -1.4 0.0 -0.9 -1.5 0.5 -1.2 -0.0 -0.8 -0.8 -1.3 -2.0 -1.0
Breast Cancer 2.0 4.9 12.0 -2.8 -3.5 -3.2 2.0 -1.9 -1.6 -0.1 -1.6 -2.6 -3.2 1.1 -1.6 -0.9
Ovarian Cancer 0.7 0.9 2.1 1.2 0.9 -0.3 0.3 1.1 -0.9 1.2 1.2 0.5 -0.0 1.1 1.1 1.4
Prostate Cancer 3.1 4.3 10.8 -0.3 -0.4 -2.5 2.6 1.0 -3.0 0.7 -2.8 -3.3 -2.4 2.2 0.0 1.8
Age at First Birth 3.1 4.5 9.7 1.8 2.0 -1.2 2.7 2.6 -2.5 2.2 0.2 -1.0 0.4 3.1 2.6 2.7
Bipolar Disorder (2011) 3.3 3.2 7.1 -1.6 -2.3 -2.6 1.2 -1.6 -1.6 -1.3 -0.8 -2.7 -2.5 0.5 -1.9 -0.6
Body Mass Index (BMI) (2010) 0.3 0.5 1.3 0.6 0.5 -0.5 0.9 1.1 -0.8 0.4 -0.2 0.2 -0.6 0.7 0.4 1.1
Coronary Artery Disease (CAD) 0.4 0.5 2.0 1.2 0.5 -0.2 -0.2 0.4 0.1 0.3 0.7 0.5 1.4 0.6 1.3 -0.1
Crohns Disease (2012) 2.0 3.2 7.6 -0.0 -1.1 -2.4 2.0 0.0 -2.8 -0.7 -1.6 -2.7 -2.5 1.0 -1.0 1.8
Mean Putamen Volume 0.4 0.5 2.7 -0.0 -0.3 -0.4 0.8 -0.3 -0.5 1.7 -0.9 -0.4 -0.5 0.7 0.7 0.6
Fasting Glucose 2.2 2.6 6.6 0.9 1.0 -1.1 2.5 1.1 -2.0 2.6 -0.8 -1.2 -0.8 1.7 1.6 2.2
HbA1C 1.7 1.9 4.9 1.4 1.3 1.8 0.7 0.9 1.7 1.0 1.8 0.4 2.2 0.1 2.0 0.2
HDL Cholesterol 2.7 4.5 10.9 0.9 0.7 -1.9 2.2 2.0 -3.3 1.7 -2.4 -2.5 -2.1 2.3 0.3 3.1
LDL Cholesterol 0.2 0.4 1.1 -0.5 0.1 -0.5 1.1 1.0 -0.3 -0.1 0.0 -1.0 -0.5 0.4 0.8 -0.3
Lupus 0.2 0.2 0.8 -0.2 -0.3 0.3 0.1 -0.6 0.5 -0.9 0.5 -0.3 0.3 -0.1 0.0 -0.9
Neuroticism (2016) 1.4 2.0 5.9 0.9 1.2 2.0 -1.2 0.6 1.8 0.0 1.4 2.4 2.2 -0.7 1.2 -0.7
Primary Biliary Cirrhosis 0.8 1.2 5.5 0.8 0.4 1.0 -0.7 -0.3 1.3 -0.8 1.4 1.4 2.4 -0.3 0.7 -1.0
Rheumatoid Arthritis 0.7 0.9 5.0 -0.1 -0.8 -0.0 -0.4 -1.3 1.0 -0.3 2.2 0.8 0.6 -0.3 -0.3 -1.5
Schizophrenia (2014) 0.9 2.1 5.3 -0.9 -1.6 -2.1 1.1 -1.1 -1.0 -1.0 -2.3 -1.7 -1.6 0.9 -1.6 -0.5
Triglycerides 0.9 1.4 3.6 0.5 1.4 1.9 -0.8 0.7 1.6 0.4 1.6 0.7 1.8 -1.1 1.3 -0.3
Type 2 Diabetes (T2D) (2012) 2.2 2.5 9.3 1.6 1.2 2.0 -0.1 1.0 1.5 0.2 2.3 0.1 2.5 0.2 3.1 -0.1
Ulcerative Colitis 1.8 2.7 8.1 1.2 0.2 -1.6 2.8 1.1 -2.3 0.4 0.2 -1.7 -0.7 2.3 1.7 2.0
Blood Eosinophil Count 0.8 5.8 13.6 1.0 1.8 -1.7 1.7 2.7 -3.4 2.9 -3.7 -1.9 -2.0 2.1 0.5 3.5
Blood Platelet Count 1.2 13.5 35.5 -0.5 1.4 -3.9 4.0 3.0 -5.3 6.0 -2.4 -1.9 -4.0 4.2 1.1 4.9
Blood Red Count 0.7 7.1 32.6 -0.0 0.8 3.4 -3.0 -0.7 3.9 -1.8 0.2 5.7 2.7 -2.9 -0.2 -1.8
Blood White Count 2.0 14.6 40.6 3.2 3.0 -2.2 4.7 4.4 -5.0 4.3 -1.1 -1.0 -0.9 4.8 3.8 6.4
Heel T-Score 1.3 10.5 30.4 -1.9 0.8 2.2 -5.3 -0.7 1.6 -2.9 -4.0 3.1 -0.7 -5.5 -5.5 -0.7
BMI 0.5 3.2 8.9 3.0 2.5 0.1 0.2 2.2 -1.5 2.0 0.7 1.7 1.1 1.0 1.5 2.8
Height 0.5 9.0 30.6 3.9 3.2 -2.2 1.2 3.6 -5.5 -1.7 -1.6 0.1 -1.2 0.7 -1.9 5.5
Waist Hip Ratio (WHR) 0.7 3.3 15.8 1.1 0.1 1.8 -1.1 0.2 2.5 0.7 4.0 1.6 2.5 0.1 1.9 -1.5
Systolic Blood Pressure 2.1 10.5 21.0 4.6 4.5 3.6 -1.1 4.0 1.2 2.7 3.2 1.9 4.4 0.3 4.2 2.4
Smoking Status 0.5 1.3 3.1 1.5 1.4 1.5 -1.8 1.0 0.7 -0.6 1.1 1.3 1.0 -1.0 -0.1 0.5
Allergy or Eczema 1.3 3.4 10.9 -1.1 -0.9 -2.7 1.6 -0.1 -2.7 1.4 -2.4 -1.0 -3.3 1.1 -1.4 1.7
Cardiovascular Disease 0.6 1.9 5.4 0.8 1.0 2.1 -1.0 0.7 1.7 0.3 2.0 1.3 2.3 -0.9 1.4 -0.5
Hypothyroidism (self reported) 4.1 9.3 20.3 -1.6 -1.1 2.9 -3.8 -2.7 4.5 -1.5 3.5 4.3 2.3 -3.1 -1.1 -4.2
Respiratory disease 0.6 1.3 3.1 0.7 1.4 0.3 0.9 1.6 -0.5 1.8 -1.3 -0.6 -0.1 1.2 1.6 1.1
Type 2 Diabetes (T2D) (2018) 1.7 3.2 11.2 1.9 1.4 0.4 1.9 2.5 -0.7 1.6 -0.0 -1.3 1.2 2.6 3.4 1.4
Lung FEV1/FVC ratio 9.2 46.5 127.7 -4.3 -3.3 3.0 -9.4 -6.4 5.9 -9.1 0.8 3.5 0.2 -11.0 -11.3 -7.5
Lung FVC 1.8 9.1 27.5 1.0 0.8 -3.6 1.7 1.5 -5.2 -0.0 -3.5 -3.6 -4.5 1.5 -2.9 3.8
Neuroticism 2.0 4.9 13.8 -1.6 -1.0 1.9 -2.5 -2.4 3.7 -1.2 0.3 2.9 2.2 -2.1 -0.5 -3.5
Chronotype (morning person) 0.9 2.1 8.5 -1.2 -0.8 1.3 -0.6 -1.3 2.7 -0.6 0.3 0.9 1.6 -0.3 1.1 -2.9
Hair Pigment 0.0 0.4 1.6 0.9 0.6 -0.6 -0.7 0.1 -0.5 1.3 -0.4 1.0 0.1 0.1 -0.4 0.4
Tanning 0.2 2.4 9.6 -1.0 -1.3 -2.0 1.2 -0.4 -1.3 -1.4 -1.5 -3.1 -2.1 0.9 -1.2 -0.7
Hand grip strength (left) 1.9 4.9 11.3 1.6 1.3 -1.8 2.9 2.3 -3.4 1.3 -2.6 -1.8 -1.1 2.7 1.2 3.0
Number of treatments/medications taken 1.2 2.2 5.6 1.4 1.5 0.8 0.1 1.5 0.2 2.4 1.4 1.7 2.0 1.3 2.3 0.7
Average weekly spirits intake 0.3 0.4 2.0 0.3 0.3 0.1 0.4 0.4 -0.2 1.4 0.7 -0.1 0.4 0.3 1.1 0.9
Sensitivity / hurt feelings 2.7 4.7 11.5 -2.1 -1.7 1.6 -2.5 -3.1 3.4 -1.4 1.1 0.8 0.7 -2.4 -1.3 -3.4
Frequency of depressed mood in last 2 weeks 0.6 0.8 3.1 -1.3 -1.1 0.4 -0.5 -0.9 1.6 0.3 -0.7 0.3 0.5 -0.1 -0.0 -1.8
Hearing difficulty/problems: Yes 4.3 6.6 16.0 2.1 1.4 -1.7 3.3 2.6 -2.9 3.1 -1.8 -0.5 0.1 4.0 3.2 3.3
Relative age of first facial hair 0.5 1.1 3.9 0.5 0.8 -0.8 0.6 0.6 -1.2 2.0 0.3 1.5 0.1 0.9 0.9 1.5
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 2.8 -0.7 -0.8 -1.2 1.6 -0.7 -0.8 0.4 -0.4 0.5 -0.4 1.7 1.1 -0.1
Ever used hormone-replacement therapy (HRT) 0.6 0.8 3.6 1.9 1.1 -0.3 0.3 0.7 -1.1 -0.6 0.6 1.1 0.4 0.8 0.3 0.9
Ever had hysterectomy (womb removed) 0.9 1.0 2.6 1.5 1.6 1.2 -0.3 1.5 0.4 0.7 0.4 0.0 1.3 0.1 1.5 0.6
Systolic blood pressure, automated reading 2.2 6.4 12.0 3.2 3.5 1.9 -0.2 3.4 0.1 3.2 2.5 1.6 2.5 1.3 3.5 2.6
Eye problems/disorders: Diabetes related eye disease 0.7 0.7 2.4 -0.1 -0.2 -0.8 1.4 -0.1 -1.0 0.5 -1.0 -0.3 -0.6 1.6 1.2 0.7
Angina 0.3 0.4 1.0 -0.3 -0.6 0.1 0.4 -0.8 0.9 -0.9 0.1 0.8 1.0 0.1 0.4 -1.0
Medication for hormone replacement therapy 1.2 1.3 7.6 -0.7 -0.7 -0.8 -0.2 -0.9 -0.4 -0.7 -2.8 0.7 -1.7 -0.1 -1.6 -0.4
Vitamin and mineral supplements 0.9 1.2 4.9 0.7 1.0 1.1 -0.4 0.5 0.9 0.2 1.8 2.2 1.8 -0.5 0.8 -0.2
Supplements: Zinc 0.5 0.5 3.8 0.1 -0.5 -0.2 0.1 -0.1 -0.5 0.8 -2.0 -0.6 -0.9 0.1 -0.4 0.5
Medication: Co-codamol 1.7 2.0 4.6 1.6 1.9 1.4 -0.5 2.1 0.5 2.1 0.1 0.7 1.7 0.5 1.8 1.0
Medication: Metformin 4.0 5.6 19.0 2.2 1.5 -0.4 3.0 2.5 -1.6 3.0 0.8 -1.2 0.9 3.6 4.4 2.2
Diabetes (father) 1.1 1.3 5.2 1.6 0.8 0.6 0.9 1.2 -0.1 1.2 0.3 0.5 1.0 1.4 2.3 1.0
Diabetes (mother) 4.2 5.4 13.4 2.7 2.6 1.1 1.2 3.4 -0.8 3.2 1.9 0.2 1.5 2.0 3.7 2.6
Severe depression (siblings) 0.4 0.4 1.2 -0.7 -0.4 -1.0 1.1 -0.2 -0.8 0.5 -0.0 -0.5 -0.9 0.7 0.1 0.4
Pack years adult smoking proportion 0.6 0.9 2.6 -1.5 -1.2 -1.0 1.6 -0.6 -0.2 0.4 0.1 -1.2 -0.3 1.2 1.1 -0.3
Impedance of leg (right) 1.6 7.8 17.5 -2.2 -1.4 2.6 -3.6 -2.4 4.0 -3.0 1.7 2.0 1.1 -3.6 -2.3 -4.2
Leg fat-free mass (left) 1.3 6.6 20.8 3.8 3.1 -1.1 1.9 3.4 -3.6 1.6 -0.5 1.0 0.6 2.2 1.6 4.6
Trunk fat percentage 1.0 4.1 10.6 2.9 2.7 1.5 -1.2 2.0 -0.1 0.9 2.5 3.3 2.7 -0.3 1.4 1.7
Hand grip strength (right) 2.8 7.5 15.5 1.9 1.9 -2.0 3.5 3.1 -3.9 2.8 -2.5 -1.9 -1.3 3.4 2.0 3.9
Townsend deprivation index at recruitment 1.2 1.7 5.0 -0.1 -0.6 1.2 -1.7 -1.2 2.2 -0.1 0.4 2.2 1.4 -1.3 -0.2 -1.6
Current tobacco smoking 0.6 1.0 2.0 1.0 1.3 1.4 -1.1 1.1 0.8 0.6 0.8 1.4 1.0 -0.3 0.9 0.5
Average weekly fortified wine intake 0.7 0.8 2.4 -1.2 -1.5 -0.9 0.2 -1.5 -0.1 -1.0 0.2 0.8 -0.7 -0.3 -1.0 -0.7
Maternal smoking around birth 1.0 1.5 4.9 1.9 2.2 1.3 -1.1 1.4 0.2 0.1 0.4 1.3 1.5 -0.7 0.5 1.0
Fed-up feelings 3.3 6.1 18.3 -0.3 -0.2 3.2 -2.6 -0.8 4.3 -1.9 1.7 2.6 3.2 -2.5 0.4 -3.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.0 4.1 0.1 0.8 0.8 0.3 1.0 0.8 1.8 -0.1 0.5 1.2 1.2 2.0 0.2
Relative age voice broke 1.2 1.8 4.7 0.4 0.7 -1.5 1.4 0.9 -2.2 1.7 -0.7 0.9 -0.3 2.1 1.2 1.7
Taking other prescription medications 1.2 1.9 5.1 1.1 1.4 0.1 0.9 1.3 -0.5 2.3 0.2 1.6 1.6 1.6 2.2 0.9
Age when periods started (menarche) 1.3 3.2 9.0 0.7 1.1 -1.8 1.1 1.6 -3.0 1.7 -2.0 -1.4 -1.8 1.6 -0.6 2.9
Bilateral oophorectomy (both ovaries removed) 0.4 0.4 0.9 1.0 0.9 0.4 -0.7 0.5 -0.1 0.7 -0.4 0.7 0.5 -0.8 -0.3 0.8
Heel bone mineral density (BMD) T-score, automated (left) 1.4 3.1 9.9 -0.3 0.9 2.0 -3.0 -0.2 1.4 -1.4 -1.2 3.1 0.8 -2.5 -2.0 -0.3
Tinnitus: Yes, but not now, but have in the past 2.2 2.4 5.0 0.8 1.4 1.9 -0.4 1.3 1.8 1.0 2.1 2.2 2.1 0.3 2.0 -0.5
Qualifications: CSEs or equivalent 2.4 3.2 8.7 1.4 1.8 3.0 -1.7 1.0 2.1 -0.7 2.5 1.9 2.2 -1.5 1.2 -0.6
Serious illness, injury or assault to yourself 0.4 0.5 1.6 -1.1 -1.2 -0.8 0.4 -1.3 -0.1 -0.1 -0.3 -0.2 -0.4 -0.1 -0.1 -0.7
High blood pressure 1.9 5.3 13.8 3.1 2.5 1.8 0.1 2.0 0.5 2.4 2.8 2.3 2.9 1.2 3.7 1.6
Hayfever, allergic rhinitis or eczema 0.8 1.8 6.9 -1.0 -1.3 -2.1 0.8 -0.6 -1.7 0.3 -1.3 -0.6 -2.6 0.5 -1.6 0.7
Multivitamins +/- minerals 0.3 0.4 0.9 -0.5 -0.5 0.3 -0.8 -0.4 0.3 -0.4 -0.4 -1.0 -0.7 -0.8 -0.9 -0.3
Stomach or abdominal pain in last month 3.1 3.9 12.6 1.0 1.7 2.7 -0.4 1.8 2.1 1.8 2.8 0.9 2.6 0.4 3.6 -0.2
Supplements: Glucosamine 0.2 0.2 0.8 -0.2 -0.1 -0.6 -0.1 -0.3 -0.8 -0.3 -0.1 -0.3 -0.6 -0.0 -0.9 0.7
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.7 -0.1 -0.4 0.8 -0.9 -0.4 1.3 -1.0 0.7 0.4 1.1 -0.5 -0.1 -1.1
Medication: Atenolol 1.6 1.9 4.8 1.1 0.8 2.1 -0.8 0.6 2.2 -0.3 1.8 1.2 2.0 -0.7 1.6 -1.2
Medication: Levothyroxine sodium 4.7 7.9 18.7 -0.8 -0.5 2.7 -2.7 -1.7 4.2 -1.4 3.8 4.3 3.3 -2.2 0.3 -3.9
Sitting height 0.5 3.5 10.0 2.3 2.1 -1.1 1.5 2.9 -3.2 -0.7 -1.5 -0.8 -0.2 1.2 -0.0 3.0
Chronic bronchitis/emphysema (father) 3.2 3.8 11.1 1.3 2.0 1.9 -0.1 2.0 1.2 2.8 1.6 2.1 2.4 1.3 3.3 1.0
High blood pressure (mother) 1.7 2.4 6.7 2.1 2.6 1.6 -0.3 2.2 0.3 0.4 1.4 1.9 1.9 0.2 1.5 1.1
Body mass index (BMI) 1.0 4.4 10.3 3.2 2.9 0.5 0.2 2.5 -1.2 2.7 1.1 1.8 2.0 1.2 2.3 3.0
Impedance of leg (left) 1.1 5.2 10.5 -1.9 -1.2 2.3 -3.2 -2.0 3.2 -2.2 1.3 1.6 0.7 -3.0 -1.8 -3.2
Leg predicted mass (left) 1.3 6.8 21.3 3.9 3.2 -1.1 1.9 3.5 -3.6 1.6 -0.5 1.1 0.7 2.1 1.6 4.6
Trunk fat mass 1.2 5.3 14.0 3.7 3.3 0.8 -0.4 2.9 -1.4 1.5 1.9 3.0 2.3 0.6 1.6 3.1
Waist circumference 1.1 4.1 9.9 3.1 2.5 1.4 -0.7 1.9 0.1 1.6 2.2 2.9 2.7 0.5 2.1 1.7
Number of incorrect matches in round 1.8 3.1 9.9 -0.7 -1.1 -2.9 3.2 -0.1 -2.3 -0.1 -0.5 -1.3 -2.1 2.6 0.8 0.8
Past tobacco smoking 0.1 0.1 0.3 -0.3 -0.2 0.3 0.3 -0.1 0.6 0.5 0.3 0.2 0.0 0.3 0.5 -0.4
Alcohol usually taken with meals 0.4 0.6 1.9 -0.3 -0.5 -1.0 0.3 -0.6 -0.8 -1.4 -1.1 -0.1 -0.9 -0.0 -1.2 -0.1
Nervous feelings 0.6 1.2 4.9 -1.7 -1.3 -0.0 0.2 -1.6 1.5 0.2 -0.3 0.0 0.4 0.4 0.6 -2.2
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.7 1.8 0.0 -0.1 0.9 -0.2 0.3 1.3 1.3 -0.9 -0.5 1.1 0.4 1.3 -0.8
Hearing difficulty/problems with background noise 1.1 1.8 6.1 -0.4 -0.5 -1.6 2.5 0.2 -1.2 1.2 -1.2 -0.6 -0.3 2.4 1.7 0.6
Hair/balding pattern: Pattern 2 1.1 1.4 5.2 1.1 1.7 1.8 -0.8 0.7 1.4 0.0 1.2 0.6 2.3 -0.6 1.0 -0.3
Had menopause 1.6 2.0 7.1 0.3 -0.4 -2.7 1.4 -0.4 -2.5 -0.1 -1.6 -0.1 -1.7 1.1 -1.3 1.5
Had other major operations 1.2 1.5 6.9 -1.2 -0.7 -1.7 1.6 -0.0 -1.3 0.1 -2.6 0.7 -1.1 1.1 -0.6 0.4
Forced vital capacity (FVC) 1.1 4.3 13.6 2.2 1.7 -1.6 0.3 2.1 -3.7 -1.3 -1.9 -1.2 -1.9 -0.4 -2.4 3.4
Heel bone mineral density (BMD) T-score, automated (right) 2.1 4.8 16.0 -0.1 1.1 2.5 -4.0 -0.1 2.0 -2.1 -0.7 3.2 0.9 -3.3 -2.7 -0.9
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 2.7 -0.2 0.5 0.8 -0.4 0.4 0.5 1.6 -0.2 1.5 0.7 0.1 0.5 0.4
Qualifications: None of the above 0.8 1.7 4.8 -0.5 -0.2 1.5 -2.2 -0.8 2.0 -0.8 0.7 0.6 1.3 -1.9 -0.7 -1.6
Financial difficulties in last 2 years 0.5 0.7 1.8 0.7 0.9 1.3 -1.0 1.0 0.9 0.2 0.5 1.4 1.0 -0.6 -0.1 0.1
Mouth/teeth dental problems 2.1 3.2 7.3 0.0 -0.2 -2.1 2.5 0.6 -2.5 1.5 -2.3 -1.7 -1.7 2.7 0.9 1.9
Heart attack 1.2 1.6 6.0 1.7 1.4 1.0 -0.3 0.9 0.7 -1.0 1.8 1.2 2.5 -0.1 1.2 -0.1
Allergy 1.0 2.3 5.1 -0.1 0.0 1.9 -2.0 -0.7 2.2 -1.7 1.4 0.2 2.0 -2.1 -0.6 -1.9
Pain all over the body in last month 3.0 3.2 7.2 1.5 2.2 2.5 -0.3 1.9 1.6 0.3 2.2 2.0 2.7 -0.1 2.4 0.2
Diabetes (self-reported) 1.9 2.9 11.3 1.0 0.9 -0.0 2.0 1.7 -0.6 2.6 0.2 -1.0 0.9 2.5 3.4 1.3
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 1.5 -1.1 -1.2 -0.1 0.1 -0.9 0.5 0.2 -0.8 0.0 -0.5 -0.4 -0.5 -0.7
Medication: Ramipril 2.2 2.9 6.8 2.6 1.6 -0.0 1.5 1.8 -1.2 2.5 0.1 0.7 1.0 1.6 2.2 2.4
Medication: Simvastatin 0.4 0.6 1.4 0.9 1.0 0.6 -0.1 0.8 0.4 1.1 0.3 0.6 1.1 0.3 1.2 0.2
Fluid intelligence score 1.6 3.2 8.2 -2.1 -2.2 -0.1 -1.5 -2.6 0.9 -1.7 -0.0 -0.9 -1.5 -2.3 -2.9 -1.9
Illnesses of siblings 2.1 2.9 9.2 -1.8 -1.7 -1.7 -0.2 -1.7 -1.2 -0.7 -2.4 -0.7 -2.8 -0.8 -3.0 -0.1
Neuroticism score 2.9 6.0 18.5 -1.4 -0.9 2.6 -3.0 -2.0 4.3 -1.5 1.0 2.3 2.3 -2.8 -0.6 -3.8
Weight 1.4 7.1 20.8 4.4 3.7 -0.1 0.8 3.5 -2.8 2.1 0.5 2.0 1.7 1.6 2.0 4.6
Impedance of arm (right) 1.6 7.5 17.8 -2.6 -2.0 2.0 -2.9 -2.4 3.6 -3.7 1.2 1.2 1.1 -3.6 -2.5 -4.2
Arm fat percentage (right) 1.0 4.1 9.5 2.7 2.6 1.7 -1.2 1.8 0.3 1.3 2.3 3.1 3.1 -0.3 1.7 1.6
Trunk fat-free mass 1.2 7.1 24.2 4.1 3.2 -1.3 1.7 3.4 -4.0 1.5 -1.1 0.8 0.1 2.0 1.1 4.9
Hip circumference 0.5 2.1 6.1 2.1 1.8 1.4 -1.3 0.9 0.3 -0.2 1.4 2.5 2.1 -1.0 0.4 1.0
Time employed in main current job 1.4 1.6 5.1 1.0 0.5 -1.3 1.6 1.2 -1.6 1.5 0.1 -0.4 -0.3 2.3 1.4 1.3
Alcohol intake versus 10 years previously 0.7 1.1 3.3 0.5 1.0 1.8 -1.5 0.5 1.4 0.3 0.5 0.8 1.4 -1.1 0.7 -0.3
Father’s age at death 0.4 0.5 1.4 -0.4 -0.6 -1.2 1.0 -0.2 -1.0 -0.9 -0.1 -0.4 -1.1 0.9 -0.4 0.0
Worrier / anxious feelings 1.0 1.9 5.8 -2.4 -1.1 0.3 -0.6 -1.8 1.8 -0.8 0.7 1.5 0.1 -1.0 -0.9 -2.4
Frequency of tiredness / lethargy in last 2 weeks 1.2 1.9 6.2 1.3 1.1 1.5 -0.2 1.0 1.2 1.5 0.6 1.9 2.5 0.2 2.2 0.6
Falls in the last year 0.7 0.9 3.6 1.1 0.7 0.6 -0.4 0.1 0.6 0.5 1.5 1.2 1.9 0.4 1.2 -0.0
Hair/balding pattern: Pattern 3 0.4 0.6 1.3 1.0 0.6 -0.1 0.7 0.8 -0.5 0.8 0.9 0.4 0.3 1.2 1.0 0.8
Number of live births 5.9 8.4 20.3 -2.4 -2.0 1.9 -3.3 -3.0 3.8 -3.1 2.1 2.5 0.9 -3.7 -2.6 -4.5
Forced expiratory volume in 1-second (FEV1) 1.9 6.4 34.3 0.2 0.3 -0.4 -2.8 -0.5 -1.2 -4.1 -1.4 -0.4 -1.8 -4.1 -5.9 0.5
Pulse rate 0.5 0.8 2.0 1.1 1.2 1.0 0.0 1.3 0.5 0.3 1.2 0.6 0.9 0.3 1.4 0.3
Happiness 0.4 0.5 1.9 0.0 0.1 0.0 0.4 0.2 0.3 1.1 0.8 -0.8 0.9 0.7 1.4 -0.3
Noisy workplace 0.5 0.6 2.1 -0.2 -0.4 -1.0 1.5 -0.1 -0.8 -0.2 -0.2 -1.1 0.1 1.4 0.7 -0.0
Qualifications: A levels/AS levels or equivalent 0.6 1.2 3.3 0.7 -0.2 -1.6 1.4 0.4 -1.8 0.8 0.2 -1.3 -1.2 1.5 0.4 1.3
Serious illness, injury or assault of a close relative in last 2 years 1.3 1.4 3.5 0.4 0.5 1.7 -1.9 -0.1 1.8 -0.8 1.1 1.4 1.5 -1.3 -0.2 -1.1
Mouth/teeth dental problems: Dentures 2.8 4.7 13.5 0.9 1.0 2.7 -3.7 0.5 2.4 -1.9 2.8 1.2 1.9 -3.4 -1.5 -1.4
Asthma 0.6 1.2 3.2 -0.8 -0.3 -1.0 1.4 -0.2 -0.7 1.4 -1.8 -0.9 -1.4 1.6 0.5 0.6
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.8 3.7 0.3 0.3 1.1 -1.4 0.3 0.9 0.3 1.9 1.4 0.6 -0.8 -0.2 0.1
Medication: Cholesterol lowering 1.1 1.7 4.3 0.7 0.4 -0.9 2.0 0.8 -1.0 1.7 0.3 -1.4 0.3 2.1 2.1 0.8
Depression (self-reported) 0.2 0.3 0.8 -0.4 -0.6 0.3 -0.3 -0.8 0.8 -0.5 -0.5 0.1 0.3 -0.1 0.0 -0.9
Medication: Lansoprazole 0.9 1.1 3.7 0.2 0.7 1.1 -1.8 0.1 0.8 0.2 0.5 1.9 1.2 -1.5 -0.4 -0.3
Prospective memory result 0.8 1.0 4.2 -0.5 -0.6 -0.7 1.0 -0.0 -0.5 0.9 -2.0 -1.8 -0.8 0.8 0.1 0.1
Lung cancer (father) 0.4 0.5 1.9 0.3 0.2 -0.7 0.4 -0.1 -0.7 0.6 -1.4 -1.0 -0.6 0.9 0.2 0.5
Illnesses of mother 2.4 3.0 7.7 -2.4 -2.4 -0.5 -1.3 -2.8 0.7 -1.0 -0.7 -0.9 -1.9 -1.6 -2.6 -1.5
Forced expiratory volume in 1-second (FEV1), Best measure 1.9 5.9 29.5 -0.4 -0.1 -0.2 -2.7 -0.7 -0.8 -4.2 -1.3 -0.6 -1.6 -4.0 -5.4 -0.2
Pulse wave Arterial Stiffness index 2.0 2.3 6.1 1.5 1.7 1.7 -1.1 1.2 1.3 0.3 1.9 2.4 2.5 -0.1 1.3 0.1
Impedance of arm (left) 1.4 6.5 17.1 -2.6 -2.3 1.5 -2.3 -2.5 3.2 -3.6 1.4 1.0 0.6 -3.1 -2.3 -4.1
Arm fat mass (right) 1.2 4.9 12.1 3.5 3.2 1.0 -0.3 2.7 -0.9 1.8 1.6 2.8 2.6 0.5 2.0 2.9
Trunk predicted mass 1.2 6.8 23.3 4.0 3.2 -1.3 1.7 3.3 -3.9 1.4 -1.1 0.7 -0.0 2.0 1.0 4.8
Standing height 0.4 4.3 14.2 3.0 2.2 -1.3 1.3 2.7 -3.7 -1.0 -1.0 0.6 -0.4 1.0 -0.6 3.8
Length of working week for main job 0.9 0.9 2.6 -0.2 -0.6 -1.3 1.0 -0.1 -1.5 0.0 -0.4 -1.5 -1.6 1.1 -0.2 0.7
Exposure to tobacco smoke at home 1.5 1.7 5.1 -2.3 -2.1 -1.3 0.3 -2.0 -0.1 0.1 -0.9 -1.2 -1.3 -0.2 -1.5 -1.0
Breastfed as a baby 1.3 1.6 4.2 0.8 0.2 -1.7 2.1 0.7 -2.0 0.8 -0.7 -0.8 -0.7 1.8 0.6 1.5
Tense / ‘highly strung’ 1.3 2.2 6.0 -2.2 -2.1 -0.6 -0.4 -2.3 1.2 -0.1 -2.5 0.6 -0.7 -0.4 -1.3 -1.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.4 2.2 0.5 0.5 0.6 -1.3 -0.2 0.5 -0.0 -0.1 1.5 0.7 -0.3 -0.2 -0.2
Hair/balding pattern: Pattern 4 1.0 2.4 5.6 1.5 0.9 -1.0 2.2 1.9 -2.4 1.4 0.2 -0.4 -0.4 2.0 1.4 2.2
Birth weight of first child 0.9 1.7 4.2 1.1 0.8 -1.1 1.5 1.4 -1.6 0.6 -0.5 -1.9 0.2 2.0 1.4 1.3
Peak expiratory flow (PEF) 1.2 2.7 11.4 0.8 0.7 0.1 -1.9 -0.3 -0.4 -3.2 -0.5 0.0 -0.2 -2.8 -3.4 0.2
Pulse wave reflection index 0.6 0.8 2.2 0.0 -0.4 0.8 -1.5 -0.4 1.3 -0.7 0.4 -0.3 0.8 -1.4 -0.8 -1.2
Ever highly irritable/argumentative for 2 days 0.5 0.5 3.1 0.1 0.5 0.9 -0.2 0.2 0.8 -0.3 -0.4 0.2 1.8 0.3 1.0 -0.8
Loud music exposure frequency 0.5 0.6 1.6 -1.1 -1.3 -0.9 0.0 -0.9 0.3 -0.0 -0.1 -0.2 -0.8 -0.3 -1.0 -1.1
Qualifications: O levels/GCSEs or equivalent 1.0 1.7 4.6 2.1 1.8 0.5 0.5 1.8 -0.9 1.3 0.2 0.8 0.8 0.4 1.3 2.1
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 2.0 -0.7 -1.0 0.1 -0.2 -1.4 1.2 0.4 0.3 0.8 0.4 -0.2 0.1 -1.3
Blood clot in the leg (DVT) 1.8 2.3 6.9 1.1 0.8 -1.5 1.7 1.4 -2.6 1.0 -0.7 0.4 -1.2 1.9 0.8 2.5
Medication: Paracetamol 1.4 2.3 9.8 -0.3 -0.1 1.6 -0.7 -0.0 2.1 0.6 3.1 2.0 1.9 -0.4 1.6 -1.3
Headache pain in last month 1.9 3.3 8.5 -0.8 -0.7 1.8 -2.4 -1.1 2.9 -1.3 1.7 2.2 1.7 -2.1 -0.7 -2.5
Medication for cholesterol, blood pressure or diabetes 1.6 2.6 8.1 -2.0 -2.0 -1.3 -0.3 -1.8 -0.5 -2.1 -1.2 -0.1 -2.3 -0.9 -2.8 -1.0
Glaucoma (self-reported) 2.1 2.4 7.7 0.9 1.3 -0.2 1.7 1.9 -1.0 2.2 0.7 1.0 0.6 2.2 2.8 1.6
Gout (self-reported) 1.3 1.8 5.2 1.2 1.3 0.4 1.3 2.3 -0.6 1.6 0.5 -0.3 1.0 1.4 2.1 1.6
Hypothyroidism/myxoedema (self-reported) 4.1 8.0 18.4 -0.9 -0.2 3.1 -3.3 -1.6 4.3 -1.0 3.7 4.3 3.0 -2.5 0.0 -3.6
Medication: Amlodipine 3.9 5.4 11.5 3.4 3.3 2.7 -0.7 3.0 0.9 1.8 1.9 1.2 3.1 0.4 3.3 1.5
Medication: Ventolin 100micrograms inhaler 1.6 2.0 7.3 0.4 0.4 -1.1 1.5 1.1 -1.4 2.1 -2.7 -0.9 -1.0 2.0 0.8 1.2
Birth weight 4.1 8.9 23.8 1.4 0.5 -3.6 3.5 2.0 -4.9 2.7 -3.2 -3.1 -2.2 3.3 0.5 4.2
Chronic bronchitis/emphysema (mother) 1.2 1.4 5.2 1.3 1.2 0.6 0.6 1.3 -0.1 1.8 0.5 0.4 0.8 1.2 2.3 1.3
High blood pressure (siblings) 1.1 1.6 4.1 1.2 1.3 1.9 -0.6 1.1 1.3 0.8 1.3 0.3 2.0 -0.0 2.0 0.1
Forced vital capacity (FVC), Best measure 1.0 3.5 10.2 1.4 1.1 -1.4 0.2 1.5 -3.2 -1.6 -2.1 -1.9 -2.0 -0.6 -2.5 2.6
Body fat percentage 1.2 4.5 10.4 3.0 2.9 1.5 -1.1 2.2 -0.2 1.5 2.4 3.2 2.8 -0.0 1.7 2.1
Leg fat percentage (right) 1.3 4.8 10.2 3.0 3.1 1.8 -1.3 2.1 0.2 1.9 2.4 3.2 2.8 -0.0 1.8 1.9
Arm fat-free mass (right) 1.5 7.6 24.6 4.1 3.2 -1.4 2.0 3.5 -4.0 1.7 -0.6 0.8 0.0 2.5 1.6 5.0
Exposure to tobacco smoke outside home 0.3 0.4 2.2 -0.4 -0.2 -0.5 -0.2 -0.1 -0.5 1.3 -1.5 0.1 -0.5 0.0 -0.5 0.6
Comparative body size at age 10 3.0 8.2 22.1 3.6 2.6 -1.4 2.7 3.3 -3.6 3.3 -0.7 -1.0 -0.2 3.3 2.7 4.7
Number of full brothers 1.4 1.8 4.3 -0.2 0.8 2.1 -1.2 0.4 2.0 -1.2 1.6 1.1 1.8 -1.4 0.5 -1.4
Worry too long after embarrassment 0.6 1.1 2.7 -1.0 -1.4 -1.6 1.0 -1.5 -0.8 1.2 -0.7 -0.5 -1.2 0.7 -0.3 0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 2.9 -0.4 -0.4 0.4 -0.9 -1.0 0.5 0.0 -1.7 -0.1 0.0 -0.8 -0.7 -0.5
Wheeze or whistling in the chest in last year 1.7 3.1 10.2 1.1 1.0 2.3 -1.1 0.5 2.4 0.8 1.5 3.2 2.6 0.1 2.4 -0.7
Number of children fathered 3.1 3.5 9.0 0.4 0.7 2.7 -2.8 -0.2 2.7 -1.0 2.2 1.5 1.6 -3.0 -0.6 -1.7
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.4 1.4 0.7 0.4 0.0 0.6 0.9 -0.2 1.0 0.0 -0.7 0.2 0.6 1.2 0.5
Age at first live birth 3.1 5.5 16.4 -1.0 -1.6 -3.4 4.0 -0.3 -2.9 1.1 -1.9 -2.6 -2.5 3.5 0.6 1.3
Pulse wave peak to peak time 1.8 2.1 5.8 -1.1 -1.3 -1.8 1.2 -0.8 -1.6 -0.4 -1.8 -2.3 -2.4 0.2 -1.3 0.3
Health satisfaction 1.2 1.5 6.2 0.4 0.8 -0.1 1.3 1.1 -0.5 2.5 0.1 0.2 0.4 1.4 2.3 1.4
Shortness of breath walking on level ground 0.2 0.3 0.8 -0.9 -0.6 0.3 -0.3 -0.6 0.7 0.2 0.1 0.5 0.1 -0.7 -0.2 -0.6
Qualifications: College or University degree 3.7 11.8 27.9 0.7 -0.1 -4.2 5.3 1.8 -4.8 2.7 -2.6 -3.9 -3.2 4.9 2.0 3.5
Eye problems/disorders: None of the above 1.7 2.0 7.2 -0.4 -0.9 -0.0 -1.5 -1.6 0.6 -2.1 -1.4 -0.6 -0.2 -2.1 -2.7 -1.1
Mouth/teeth dental problems: Loose teeth 0.3 0.4 1.2 -0.1 0.3 0.5 -0.8 -0.1 0.6 -0.4 0.9 -1.1 0.2 -0.8 -0.3 -0.6
Emphysema/chronic bronchitis 0.5 0.5 1.4 0.9 0.4 -0.2 0.5 0.3 0.0 0.4 1.1 1.0 1.1 0.7 1.2 0.0
Medication for pain relief, constipation, heartburn 0.7 1.1 5.3 -0.1 0.3 -0.0 -0.5 -0.3 -0.5 -1.6 -2.3 -0.4 -1.2 -1.1 -1.8 0.2
Neck or shoulder pain in last month 0.2 0.2 0.7 -0.5 -0.2 -0.4 0.4 0.6 -0.2 0.6 -0.4 -0.8 -0.6 0.5 0.3 0.1
Medication: Blood pressure 4.3 7.6 17.5 4.1 3.5 2.7 -0.3 2.9 1.0 2.0 3.1 1.3 4.2 0.9 4.1 1.7
Angina (self-reported) 0.5 0.6 1.3 -0.2 -0.7 0.1 0.3 -0.9 1.0 -1.1 0.4 1.0 1.1 0.0 0.4 -1.1
Migraine (self-reported) 1.9 2.4 7.8 -0.7 -1.7 1.0 -1.5 -1.8 2.3 -1.8 0.7 -0.0 0.5 -1.8 -1.2 -2.8
Medication: Ibuprofen 1.6 2.0 5.7 1.4 1.4 1.6 -1.1 1.6 0.8 1.1 2.4 1.7 1.6 -0.2 1.0 0.9
Medication: Allopurinol 1.4 1.9 4.3 1.1 1.2 -0.0 1.4 1.9 -0.9 1.9 0.1 1.0 0.8 1.9 2.1 1.7
Medication: Omeprazole 0.6 0.7 1.7 -0.8 -0.9 0.5 -0.5 -1.2 1.3 0.3 -0.9 0.5 0.9 -0.5 0.0 -1.3
Medication: Seretide 50 evohaler 0.5 0.5 2.6 0.4 -0.1 -1.0 0.9 0.2 -1.0 0.5 -0.2 -1.6 -0.4 0.8 0.3 0.5
Mean time to correctly identify matches 1.4 2.7 7.6 -2.2 -2.6 -2.1 0.4 -2.8 -0.6 -1.0 -0.4 0.2 -2.3 0.1 -1.8 -0.9
Heart disease (mother) 2.0 2.5 8.5 2.2 2.0 1.7 -0.7 2.2 1.0 -0.4 1.6 -0.0 2.9 -0.7 1.4 0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.5 4.2 11.6 -1.2 -1.3 1.2 -2.5 -2.4 2.6 -2.3 1.5 0.9 0.2 -3.4 -2.2 -2.5
Whole body fat mass 1.5 6.1 15.6 4.0 3.6 1.0 -0.3 3.1 -1.3 1.9 1.8 3.0 2.5 0.7 2.0 3.3
Leg fat mass (right) 1.5 5.8 14.4 3.8 3.5 0.9 -0.2 3.0 -1.3 2.3 1.5 3.0 2.3 0.9 2.0 3.3
Arm predicted mass (right) 1.6 8.2 25.9 4.3 3.4 -1.3 2.0 3.8 -4.0 1.9 -0.4 0.7 0.1 2.5 1.8 5.1
Pulse rate, automated reading 0.1 0.4 2.4 -0.4 0.1 0.7 0.5 -0.0 1.0 0.9 -0.6 0.3 -0.1 0.4 1.6 -0.2
Alcohol intake frequency. 0.5 1.1 6.0 -0.4 -0.1 1.1 -0.8 -0.9 1.5 0.3 0.5 2.4 1.2 -0.4 0.6 -1.1
Comparative height size at age 10 0.5 3.0 8.4 2.9 2.5 -0.3 -0.2 2.5 -2.2 -1.2 -1.4 0.7 0.1 -0.5 -1.1 2.9
Number of full sisters 1.7 2.0 5.8 0.3 0.9 1.6 -2.4 -0.0 1.6 -1.5 0.6 1.6 1.5 -2.0 -1.1 -1.3
Suffer from ‘nerves’ 1.2 1.9 7.6 -0.7 -0.5 1.9 -1.5 -1.0 2.8 -0.5 0.6 -0.4 1.5 -0.9 0.4 -2.3
Overall health rating 0.9 1.9 7.2 0.9 0.7 0.7 0.6 1.4 0.6 2.6 0.6 1.2 1.4 1.4 2.7 0.5
Chest pain or discomfort 0.2 0.3 1.3 -0.1 -0.4 -0.2 0.9 -0.1 0.1 0.1 1.2 0.6 0.2 0.6 1.1 0.0
Had major operations 0.3 0.4 0.9 -0.3 -0.1 -0.2 -0.9 -0.7 0.2 -0.4 0.8 0.8 0.8 -0.2 -0.3 -1.0
Age at last live birth 1.5 2.2 6.4 -1.2 -1.4 -2.2 2.5 -0.7 -1.3 -0.3 -1.8 -1.2 -1.7 2.0 -0.1 -0.0
Family relationship satisfaction 0.8 0.9 3.7 -1.2 -1.6 -0.2 0.3 -1.5 1.2 -0.4 0.6 0.2 -0.1 0.2 0.2 -1.9
Leg pain on walking 1.0 1.3 4.3 -0.4 0.0 -1.6 1.4 0.0 -1.8 0.6 -2.1 -0.4 -0.8 1.3 -0.2 1.1
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.8 2.4 0.8 1.2 1.2 -0.9 1.0 0.2 0.1 1.6 0.5 1.1 -0.4 0.5 0.5
Commuting to job workplace: Car/motor vehicle 1.7 1.9 5.1 0.7 0.4 2.2 -1.9 -0.1 2.3 -1.0 1.0 1.1 1.6 -1.8 0.0 -1.4
Illness, injury, bereavement, stress in last 2 years 0.6 0.8 2.0 -0.9 -1.1 -1.2 1.2 -0.8 -0.9 -0.2 0.4 -0.9 -1.4 0.8 -0.1 -0.1
Medication: Aspirin 0.3 0.4 1.1 -0.2 -0.8 -0.9 0.6 -0.4 -0.2 0.1 1.1 -1.0 -0.4 0.4 0.1 -0.5
Supplements: Vitamin C 0.8 1.0 3.5 -0.7 -1.0 -0.9 -0.2 -0.6 -0.6 -0.5 -1.9 -0.7 -1.7 -0.1 -1.5 0.0
Knee pain experienced in last month 1.5 2.4 8.0 -1.1 -0.7 -2.4 0.2 -0.8 -1.7 -0.9 -1.8 -1.4 -2.3 -0.6 -2.8 0.7
Hypertension (Self-reported) 1.8 5.0 11.4 3.0 2.3 1.9 -0.2 1.7 0.7 2.2 3.0 2.5 3.1 0.9 3.4 1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 2.7 -0.4 0.7 1.3 -1.6 0.4 1.1 0.0 -0.7 -0.0 0.7 -1.3 -0.2 -0.5
Illnesses of father: Heart disease 0.2 0.3 1.8 0.3 -0.0 0.7 0.1 -0.1 0.5 -0.4 0.8 -0.1 1.4 -0.5 0.6 -0.2
Illnesses of siblings: Diabetes 0.8 1.0 2.2 1.0 1.2 1.5 0.0 1.5 0.5 0.3 1.5 0.4 1.0 0.3 1.5 0.5
Smoking status: Previous 0.3 0.5 1.6 -0.3 -0.5 -0.8 -0.0 -0.5 -0.8 -1.1 -0.7 -0.7 -0.6 -0.6 -1.3 0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 1.9 0.4 0.4 -0.2 0.2 0.9 -1.0 -1.4 -1.2 -0.7 -0.3 -0.4 -0.9 0.7
Whole body fat-free mass 1.3 7.5 24.7 4.0 3.2 -1.4 2.0 3.5 -4.0 1.6 -0.9 0.8 0.2 2.3 1.4 5.0
Leg fat-free mass (right) 1.4 7.6 25.1 3.8 3.0 -1.6 2.4 3.5 -4.1 1.9 -0.9 0.5 0.1 2.5 1.7 5.0
Arm fat percentage (left) 1.0 3.9 8.5 2.8 2.6 1.4 -0.8 1.9 -0.1 1.5 2.2 2.9 2.7 0.0 1.8 1.8
Average weekly red wine intake 0.9 1.3 4.3 1.2 0.4 -1.5 1.6 0.7 -2.1 0.2 -0.7 -0.8 -0.2 1.5 0.3 1.3
Handedness (chirality/laterality): Left-handed 0.3 0.3 1.9 -0.6 -0.4 -0.5 0.2 -0.2 -0.1 -1.4 -0.3 0.0 0.2 -0.5 -1.0 -0.4
Mood swings 4.2 7.6 22.3 -0.9 -0.9 3.3 -3.4 -1.6 4.7 -2.4 1.7 1.8 2.8 -3.4 -0.6 -4.1
Loneliness, isolation 0.7 1.0 3.4 0.4 -0.1 1.0 -1.0 -0.5 1.3 -0.5 1.2 1.8 1.4 -0.6 0.2 -1.0
Long-standing illness, disability or infirmity 1.1 1.6 6.4 0.3 0.0 -0.4 1.7 0.4 -0.2 2.1 -1.1 0.5 0.7 2.2 2.5 0.2
Ever had bowel cancer screening 0.6 0.7 2.7 0.5 0.4 0.3 -0.2 0.1 0.4 1.1 0.9 1.6 1.2 0.7 1.3 0.0
Diabetes diagnosed by doctor 1.9 3.0 12.7 1.8 1.3 0.3 1.9 1.8 -0.5 1.8 0.5 -0.5 1.7 2.6 3.6 1.1
Ever had stillbirth, spontaneous miscarriage or termination 2.7 2.9 7.2 -1.5 -1.7 0.6 -1.4 -2.7 2.1 -1.4 -0.9 1.3 0.4 -2.2 -1.6 -2.5
Friendships satisfaction 0.8 1.0 3.0 -1.7 -1.5 -0.2 -0.2 -1.0 1.0 -0.4 0.2 -1.1 -0.3 -0.8 -0.5 -1.7
Qualifications: nursing, teaching 2.0 3.2 8.7 -1.1 -1.4 -3.0 2.4 -0.8 -2.4 0.7 -1.5 -1.1 -2.9 2.0 -0.8 0.9
Commuting to job workplace: Walk 2.0 2.1 5.7 1.1 0.2 -1.4 1.9 0.8 -1.8 2.4 -0.0 -1.4 -0.6 2.0 1.4 1.8
Eye problems/disorders: Cataract 0.6 0.7 2.4 -0.7 -0.6 -0.9 1.6 0.2 -0.4 0.8 0.6 -0.7 -0.5 1.5 1.0 -0.0
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 1.1 -0.3 0.4 0.7 -0.4 0.0 0.8 1.0 0.8 1.0 0.6 -0.5 0.7 -0.2
Medication for cholesterol 0.7 1.0 5.5 0.2 -0.0 -0.8 1.6 0.8 -0.9 -0.3 0.6 -2.4 -0.0 1.3 0.8 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 2.7 -1.1 -0.6 -0.4 0.6 -0.4 -0.1 1.7 -1.2 -0.3 -0.4 0.6 0.5 0.2
Back pain experienced in last month 3.4 4.9 11.8 -2.3 -1.8 1.6 -2.5 -2.6 3.4 -1.7 0.5 1.9 0.9 -2.7 -1.5 -3.2
Mineral and other dietary supplements 0.8 1.0 2.4 0.7 1.2 1.3 -0.0 1.1 0.7 0.3 1.0 1.5 1.6 -0.0 1.5 0.1
Breast cancer (self-reported) 0.3 0.3 1.0 0.2 0.8 -0.1 0.4 0.9 -0.9 -0.4 0.5 -0.1 0.1 0.1 0.2 1.0
Asthma (self-reported) 0.6 1.3 3.1 -0.7 -0.2 -1.0 1.6 -0.1 -0.9 1.5 -1.7 -0.9 -1.3 1.8 0.6 0.7
Osteoporosis (self-reported) 0.7 0.9 2.5 0.5 0.8 0.0 0.6 0.5 -0.2 1.4 1.0 1.3 1.0 1.3 1.6 0.6
Osteoarthritis (self-reported) 3.5 4.5 10.1 0.5 0.1 -2.7 2.6 1.1 -3.2 2.8 -0.4 -1.9 -1.8 3.1 1.0 2.6
Medication: Aspirin 0.2 0.3 1.7 0.0 -0.7 -0.7 0.5 -0.4 -0.1 -0.1 1.3 -0.7 0.1 0.4 0.1 -0.5
Medication: Gliclazide 3.1 3.5 10.1 2.5 2.2 1.5 0.3 2.3 0.1 2.3 1.3 0.1 2.1 1.4 3.2 1.8
Illnesses of father: None of the above (group 1) 0.7 0.9 2.8 -1.2 -0.7 -0.4 -0.6 -0.9 -0.1 -1.1 -0.4 -1.1 -1.3 -0.9 -1.7 -0.8
Smoking status: Current 0.5 0.7 1.7 0.9 1.0 1.2 -1.2 0.8 0.8 0.4 0.9 1.3 0.9 -0.3 0.6 0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.7 5.7 24.2 -1.5 -1.1 0.4 -2.8 -1.8 0.5 -3.5 -0.2 -1.1 -1.5 -4.2 -4.9 -1.5
Whole body water mass 1.3 7.7 25.5 4.1 3.3 -1.3 2.0 3.6 -4.1 1.7 -1.0 0.7 0.2 2.3 1.4 5.1
Leg predicted mass (right) 1.4 7.7 25.5 3.8 3.0 -1.6 2.4 3.5 -4.2 1.9 -1.0 0.5 0.1 2.5 1.7 5.0
Arm fat mass (left) 1.2 5.0 13.2 3.6 3.2 0.7 -0.1 2.7 -1.3 1.8 1.5 2.6 2.4 0.8 1.9 3.1
Number of self-reported non-cancer illnesses 1.0 1.7 6.2 0.9 1.0 -0.1 1.2 1.1 -0.2 2.0 0.2 0.7 1.5 2.1 2.5 0.4
Average weekly champagne plus white wine intake 0.3 0.3 0.9 -0.0 -0.8 -0.5 0.4 -0.7 0.3 -1.0 0.5 0.8 -0.3 0.2 -0.0 -1.0
Miserableness 2.9 5.1 13.8 0.8 1.4 3.6 -2.7 0.8 3.7 0.0 1.7 2.0 3.4 -1.8 1.3 -2.2
Guilty feelings 0.7 1.0 2.4 1.2 1.0 1.1 -0.3 1.1 0.7 1.5 -0.4 1.3 1.2 0.3 1.3 0.5
Wears glasses or contact lenses 1.3 1.5 4.5 0.1 -0.4 -2.1 1.3 -0.3 -2.1 0.3 -1.3 -0.4 -1.8 1.2 -0.8 1.2
Ever taken oral contraceptive pill 0.5 0.6 1.7 0.3 0.1 1.3 -1.0 0.1 0.9 -0.9 0.9 0.2 0.9 -1.0 -0.2 -0.6
Hearing aid user 3.4 3.8 9.6 -2.4 -2.4 -0.7 -0.4 -2.8 0.7 -3.1 -1.4 0.3 -1.5 -1.7 -2.8 -2.2
Mother’s age at death 3.3 4.1 10.4 -1.9 -1.8 -3.2 2.8 -0.4 -2.4 0.3 -1.4 -3.2 -2.5 1.9 -0.4 0.5
Financial situation satisfaction 0.2 0.2 0.8 0.1 0.0 0.6 -0.2 -0.0 0.9 -0.2 0.5 -0.2 0.5 0.3 0.4 -0.9
Tinnitus: Yes, now most or all of the time 0.9 1.1 3.1 1.3 1.7 0.9 -1.2 1.7 -0.2 -0.9 -0.2 -1.3 0.9 -0.5 -0.5 0.4
Commuting to job workplace: Public transport 0.4 0.5 1.3 -0.1 -0.1 -1.0 1.0 0.1 -0.9 0.7 -0.4 -0.4 -0.7 1.2 0.6 0.7
Eye problems/disorders: Glaucoma 0.7 0.8 1.9 0.2 1.0 -0.0 0.7 1.1 -0.9 1.2 0.7 1.4 0.4 0.7 1.1 1.3
Medication: Blood pressure 0.9 1.7 4.4 1.8 1.3 1.3 -1.3 0.9 0.7 1.2 2.1 1.6 1.6 -0.6 1.1 0.5
Pain type(s) experienced in last month: Hip pain 2.2 2.7 8.1 -0.7 -0.3 2.3 -2.3 -1.0 2.8 -0.9 1.3 0.1 1.7 -2.4 -0.0 -2.1
Supplements: Fish oil (including cod liver oil) 1.7 2.3 5.0 -1.0 -1.9 -1.7 0.1 -1.7 -0.8 -1.6 -0.9 -2.2 -2.2 -0.4 -2.2 -0.6
High cholesterol (Self-reported) 0.7 1.2 3.8 0.9 1.1 -0.3 0.7 1.3 -1.1 1.9 1.0 0.1 0.2 0.9 1.1 1.5
Medication: Bendroflumethiazide 2.5 3.8 12.3 2.6 2.0 2.3 -1.2 1.6 1.4 0.7 3.5 2.0 2.5 -0.1 1.9 -0.0
Medication: Paracetamol 2.1 3.2 10.0 -0.1 -0.1 2.1 -1.6 -0.3 2.7 0.1 3.2 2.5 2.4 -1.0 1.1 -1.8
Medication: Lisinopril 1.5 1.9 4.7 1.5 2.2 1.5 -0.4 1.8 0.2 1.3 1.4 -0.1 1.7 0.3 2.0 1.0
Medication: Atorvastatin 0.6 0.8 1.9 0.1 -0.2 -1.2 1.4 0.2 -0.9 1.3 -0.7 -0.2 0.4 1.3 1.1 0.8
Illnesses of father: High blood pressure 1.0 1.2 3.0 -1.3 -1.4 0.2 -0.9 -1.4 1.3 -1.4 0.5 -0.3 -0.0 -1.3 -1.0 -1.7
Alcohol drinker status: Never 3.3 4.0 10.2 -1.7 -1.5 -2.7 2.2 -0.9 -2.1 3.2 -1.8 0.1 -2.5 2.4 0.4 1.6
Ever smoked 0.3 0.6 1.8 -0.2 0.1 0.8 -1.3 -0.3 0.7 -1.2 -0.4 0.1 -0.0 -1.3 -0.8 -0.6
Basal metabolic rate 1.4 7.6 25.2 4.2 3.5 -0.9 1.6 3.7 -3.7 1.8 -0.5 1.3 0.7 2.0 1.6 5.0
Leg fat percentage (left) 1.5 5.3 10.9 3.3 3.3 1.4 -0.9 2.5 -0.5 2.6 2.0 2.9 2.5 0.5 2.2 2.7
Arm fat-free mass (left) 1.2 6.1 21.8 3.7 3.2 -1.1 1.3 3.2 -3.7 1.2 -1.0 0.9 0.2 1.6 0.8 4.7
Number of operations (self-reported) 0.7 1.0 4.0 -1.0 -0.3 -0.1 -1.2 -1.2 0.8 -0.6 -0.6 2.0 0.7 -0.6 -0.8 -1.6
Average weekly beer plus cider intake 0.4 0.6 3.0 0.2 0.6 -0.0 -0.1 0.8 -0.6 1.7 -0.0 -0.2 -0.6 0.2 0.1 1.7
Irritability 2.1 3.5 10.5 -0.4 0.2 2.5 -2.1 -0.9 3.0 -0.6 0.3 3.2 2.3 -2.4 0.0 -1.8
Risk taking 2.3 3.4 9.7 -0.1 -0.1 1.9 -3.1 -0.5 2.5 -1.4 1.9 1.7 1.2 -2.8 -1.6 -1.9
Ever had prostate specific antigen (PSA) test 0.9 1.1 4.9 -0.3 -0.4 -0.5 -0.8 -1.0 -0.5 -0.8 -2.0 0.9 -0.9 -0.9 -2.2 -0.0
Fractured/broken bones in last 5 years 0.7 0.9 5.5 0.5 0.1 0.2 0.4 0.2 0.6 0.5 2.3 0.9 1.1 0.8 1.3 -0.7
Age started oral contraceptive pill 1.8 2.2 6.0 0.2 0.1 -2.2 2.2 0.8 -2.4 1.1 0.3 -1.3 -1.3 2.4 0.4 1.7
Diastolic blood pressure, automated reading 0.7 2.2 5.5 1.9 1.4 0.5 0.4 1.5 -0.1 1.7 1.5 2.0 1.7 1.4 2.3 1.2
Ever depressed for a whole week 0.7 0.9 2.5 -1.5 -1.2 -0.6 -0.1 -1.4 0.1 -0.4 -1.1 1.6 -0.2 -0.3 -1.0 -0.5
Unable to work because of sickness or disability 1.0 1.3 2.8 -0.4 -1.0 -1.4 1.6 -0.5 -1.1 1.5 -1.4 -1.1 -0.3 1.7 1.0 0.7
Commuting to job workplace: Cycle 1.3 1.5 3.7 -0.9 -0.7 -1.9 1.9 -0.1 -1.4 1.2 -1.0 -1.0 -1.2 1.9 0.5 0.7
Myopia 2.2 3.2 6.8 0.2 -0.6 -2.2 2.1 0.3 -2.4 1.7 -2.6 -2.6 -1.8 1.8 0.4 1.9
Vascular/heart problems diagnosed by doctor 2.0 5.4 13.2 -2.9 -2.3 -2.1 0.3 -1.7 -1.2 -2.0 -3.2 -2.6 -3.5 -1.0 -3.6 -0.8
Cholesterol lowering medication 0.4 0.7 2.5 0.5 0.8 0.6 -0.5 0.3 0.3 1.2 0.9 1.6 0.9 -0.4 0.7 0.8
Medication: Omeprazole (e.g. Zanprol) 0.2 0.3 1.1 -0.3 -0.4 0.1 0.4 -0.5 0.4 0.9 -1.0 0.2 0.5 0.4 0.7 -0.4
Pain experienced in last month 0.8 1.4 5.5 0.1 -0.5 -1.3 1.9 -0.1 -1.6 0.9 -0.7 -0.6 -1.1 2.3 1.0 0.7
Supplements: Calcium 0.9 1.0 2.3 -1.3 -1.2 -1.5 1.5 -0.9 -0.8 0.3 -1.0 -1.2 -0.8 0.9 -0.2 -0.4
Basal cell carcinoma (self-reported) 0.5 0.6 4.2 0.7 0.7 -0.0 0.5 0.9 -0.6 0.3 2.1 -0.6 -0.1 0.6 0.6 0.7
Heart attack/myocardial infarction (self-reported) 1.1 1.5 5.4 1.8 1.5 0.9 0.0 1.1 0.5 -0.6 1.6 0.9 2.3 0.2 1.4 0.1
Deep venous thrombosis (DVT) (self-reported) 1.8 2.3 6.9 1.1 0.8 -1.5 1.7 1.4 -2.6 0.9 -0.7 0.6 -1.2 2.1 0.7 2.5
Heart disease (siblings) 1.9 2.4 10.3 1.1 0.3 -0.1 2.5 1.0 0.1 0.6 2.0 -0.2 1.5 2.4 3.2 0.3
Alcohol drinker status: Previous 0.5 0.6 2.6 -0.9 -0.9 -0.1 -0.0 -1.1 0.6 -0.8 -1.6 0.5 -0.0 0.2 -0.1 -1.1
Pack years of smoking 0.6 0.9 2.7 -1.4 -1.1 -1.1 1.6 -0.6 -0.3 0.7 0.1 -1.1 -0.2 1.3 1.2 -0.1
Impedance of whole body 1.7 8.8 21.3 -2.8 -2.3 2.2 -3.3 -2.8 3.9 -3.9 1.6 1.1 0.8 -3.8 -2.7 -4.6
Leg fat mass (left) 1.7 6.6 15.4 3.9 3.6 0.6 0.1 3.2 -1.8 2.7 1.4 2.8 2.1 1.3 2.3 3.9
Arm predicted mass (left) 1.3 6.4 22.2 3.8 3.3 -1.0 1.4 3.4 -3.6 1.4 -0.7 0.9 0.3 1.7 1.1 4.7