TWAS hub - ASCC2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1320	0.0530	3.3e-03	-0.005	NA	-0.005	NA	-0.004	9.0e-01	NA	9.2e-01	NA	6.1e-01
2	GTEx	Artery Tibial	0.1523	0.0629	1.3e-03	0.098	NA	0.093	NA	0.098	4.5e-08	NA	9.7e-08	NA	4.3e-08
3	GTEx	Brain Cerebellum	0.2460	0.0800	3.7e-04	0.202	NA	0.118	NA	0.196	1.3e-06	NA	2.4e-04	NA	1.9e-06
4	GTEx	Cells Transformed fibroblasts	0.0510	0.0260	5.4e-03	0.048	NA	0.034	NA	0.038	1.6e-04	NA	1.3e-03	NA	6.8e-04
5	GTEx	Nerve Tibial	0.1736	0.0620	1.1e-04	0.069	NA	0.077	NA	0.080	1.3e-05	NA	4.1e-06	NA	2.6e-06
6	GTEx	Testis	0.2770	0.0610	7.2e-14	0.305	NA	0.297	NA	0.365	4.8e-14	NA	1.2e-13	NA	4.1e-17
7	GTEx	Thyroid	0.1060	0.0390	9.8e-05	0.038	NA	0.032	NA	0.053	6.5e-04	NA	1.5e-03	NA	6.4e-05
8	GTEx	Whole Blood	0.1140	0.0490	1.7e-04	0.029	NA	0.033	NA	0.030	9.6e-04	NA	4.4e-04	NA	8.5e-04
9	NTR	Blood	0.0442	0.0177	1.3e-04	-0.001	0.013	0.012	0.012	0.002	8.2e-01	4.5e-05	8.4e-05	6.4e-05	6.1e-02
10	YFS	Blood	0.3503	0.0408	0.0e+00	0.144	0.240	0.270	0.251	0.260	8.9e-45	1.5e-77	2.0e-88	2.0e-81	9.6e-85
11	TCGA	Cervical Squamous Cell Carcinoma	0.0730	0.0480	7.5e-03	0.074	0.047	0.070	NA	0.066	1.6e-04	2.5e-03	2.5e-04	NA	3.6e-04
12	TCGA	Brain Lower Grade Glioma	0.0413	0.0243	2.5e-03	-0.001	0.013	0.012	NA	0.002	4.1e-01	1.1e-02	1.6e-02	NA	1.6e-01
13	TCGA	Prostate Adenocarcinoma	0.0359	0.0196	9.0e-04	0.016	0.027	0.028	NA	0.024	7.7e-03	7.5e-04	5.9e-04	NA	1.4e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Lung FEV1/FVC ratio	9.2	46.5	127.7	-4.3	-3.3	3.0	-9.4	-6.4	5.9	-9.1	0.8	3.5	0.2	-11.0	-11.3	-7.5
Number of live births	5.9	8.4	20.3	-2.4	-2.0	1.9	-3.3	-3.0	3.8	-3.1	2.1	2.5	0.9	-3.7	-2.6	-4.5
Medication: Levothyroxine sodium	4.7	7.9	18.7	-0.8	-0.5	2.7	-2.7	-1.7	4.2	-1.4	3.8	4.3	3.3	-2.2	0.3	-3.9
Hearing difficulty/problems: Yes	4.3	6.6	16.0	2.1	1.4	-1.7	3.3	2.6	-2.9	3.1	-1.8	-0.5	0.1	4.0	3.2	3.3
Medication: Blood pressure	4.3	7.6	17.5	4.1	3.5	2.7	-0.3	2.9	1.0	2.0	3.1	1.3	4.2	0.9	4.1	1.7
Diabetes (mother)	4.2	5.4	13.4	2.7	2.6	1.1	1.2	3.4	-0.8	3.2	1.9	0.2	1.5	2.0	3.7	2.6
Mood swings	4.2	7.6	22.3	-0.9	-0.9	3.3	-3.4	-1.6	4.7	-2.4	1.7	1.8	2.8	-3.4	-0.6	-4.1
Hypothyroidism (self reported)	4.1	9.3	20.3	-1.6	-1.1	2.9	-3.8	-2.7	4.5	-1.5	3.5	4.3	2.3	-3.1	-1.1	-4.2
Hypothyroidism/myxoedema (self-reported)	4.1	8.0	18.4	-0.9	-0.2	3.1	-3.3	-1.6	4.3	-1.0	3.7	4.3	3.0	-2.5	0.0	-3.6
Birth weight	4.1	8.9	23.8	1.4	0.5	-3.6	3.5	2.0	-4.9	2.7	-3.2	-3.1	-2.2	3.3	0.5	4.2
Depressed Affect (Nagel 2018)	4.0	8.4	20.4	1.2	1.3	4.2	-3.5	0.4	4.5	-1.1	2.9	3.4	4.2	-2.6	1.2	-3.0
Medication: Metformin	4.0	5.6	19.0	2.2	1.5	-0.4	3.0	2.5	-1.6	3.0	0.8	-1.2	0.9	3.6	4.4	2.2
Medication: Amlodipine	3.9	5.4	11.5	3.4	3.3	2.7	-0.7	3.0	0.9	1.8	1.9	1.2	3.1	0.4	3.3	1.5
Qualifications: College or University degree	3.7	11.8	27.9	0.7	-0.1	-4.2	5.3	1.8	-4.8	2.7	-2.6	-3.9	-3.2	4.9	2.0	3.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.5	4.2	11.6	-1.2	-1.3	1.2	-2.5	-2.4	2.6	-2.3	1.5	0.9	0.2	-3.4	-2.2	-2.5
Osteoarthritis (self-reported)	3.5	4.5	10.1	0.5	0.1	-2.7	2.6	1.1	-3.2	2.8	-0.4	-1.9	-1.8	3.1	1.0	2.6
Back pain experienced in last month	3.4	4.9	11.8	-2.3	-1.8	1.6	-2.5	-2.6	3.4	-1.7	0.5	1.9	0.9	-2.7	-1.5	-3.2
Hearing aid user	3.4	3.8	9.6	-2.4	-2.4	-0.7	-0.4	-2.8	0.7	-3.1	-1.4	0.3	-1.5	-1.7	-2.8	-2.2
Bipolar Disorder (2011)	3.3	3.2	7.1	-1.6	-2.3	-2.6	1.2	-1.6	-1.6	-1.3	-0.8	-2.7	-2.5	0.5	-1.9	-0.6
Fed-up feelings	3.3	6.1	18.3	-0.3	-0.2	3.2	-2.6	-0.8	4.3	-1.9	1.7	2.6	3.2	-2.5	0.4	-3.6
Mother’s age at death	3.3	4.1	10.4	-1.9	-1.8	-3.2	2.8	-0.4	-2.4	0.3	-1.4	-3.2	-2.5	1.9	-0.4	0.5
Alcohol drinker status: Never	3.3	4.0	10.2	-1.7	-1.5	-2.7	2.2	-0.9	-2.1	3.2	-1.8	0.1	-2.5	2.4	0.4	1.6
Chronic bronchitis/emphysema (father)	3.2	3.8	11.1	1.3	2.0	1.9	-0.1	2.0	1.2	2.8	1.6	2.1	2.4	1.3	3.3	1.0
Prostate Cancer	3.1	4.3	10.8	-0.3	-0.4	-2.5	2.6	1.0	-3.0	0.7	-2.8	-3.3	-2.4	2.2	0.0	1.8
Age at First Birth	3.1	4.5	9.7	1.8	2.0	-1.2	2.7	2.6	-2.5	2.2	0.2	-1.0	0.4	3.1	2.6	2.7
Stomach or abdominal pain in last month	3.1	3.9	12.6	1.0	1.7	2.7	-0.4	1.8	2.1	1.8	2.8	0.9	2.6	0.4	3.6	-0.2
Number of children fathered	3.1	3.5	9.0	0.4	0.7	2.7	-2.8	-0.2	2.7	-1.0	2.2	1.5	1.6	-3.0	-0.6	-1.7
Age at first live birth	3.1	5.5	16.4	-1.0	-1.6	-3.4	4.0	-0.3	-2.9	1.1	-1.9	-2.6	-2.5	3.5	0.6	1.3
Medication: Gliclazide	3.1	3.5	10.1	2.5	2.2	1.5	0.3	2.3	0.1	2.3	1.3	0.1	2.1	1.4	3.2	1.8
Pain all over the body in last month	3.0	3.2	7.2	1.5	2.2	2.5	-0.3	1.9	1.6	0.3	2.2	2.0	2.7	-0.1	2.4	0.2
Comparative body size at age 10	3.0	8.2	22.1	3.6	2.6	-1.4	2.7	3.3	-3.6	3.3	-0.7	-1.0	-0.2	3.3	2.7	4.7
Neuroticism score	2.9	6.0	18.5	-1.4	-0.9	2.6	-3.0	-2.0	4.3	-1.5	1.0	2.3	2.3	-2.8	-0.6	-3.8
Miserableness	2.9	5.1	13.8	0.8	1.4	3.6	-2.7	0.8	3.7	0.0	1.7	2.0	3.4	-1.8	1.3	-2.2
Hand grip strength (right)	2.8	7.5	15.5	1.9	1.9	-2.0	3.5	3.1	-3.9	2.8	-2.5	-1.9	-1.3	3.4	2.0	3.9
Mouth/teeth dental problems: Dentures	2.8	4.7	13.5	0.9	1.0	2.7	-3.7	0.5	2.4	-1.9	2.8	1.2	1.9	-3.4	-1.5	-1.4
HDL Cholesterol	2.7	4.5	10.9	0.9	0.7	-1.9	2.2	2.0	-3.3	1.7	-2.4	-2.5	-2.1	2.3	0.3	3.1
Sensitivity / hurt feelings	2.7	4.7	11.5	-2.1	-1.7	1.6	-2.5	-3.1	3.4	-1.4	1.1	0.8	0.7	-2.4	-1.3	-3.4
Ever had stillbirth, spontaneous miscarriage or termination	2.7	2.9	7.2	-1.5	-1.7	0.6	-1.4	-2.7	2.1	-1.4	-0.9	1.3	0.4	-2.2	-1.6	-2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.7	5.7	24.2	-1.5	-1.1	0.4	-2.8	-1.8	0.5	-3.5	-0.2	-1.1	-1.5	-4.2	-4.9	-1.5
Bipolar Disorder (2018)	2.5	3.9	8.0	-1.7	-2.8	-2.6	0.4	-2.1	-1.0	-1.6	-1.5	-2.7	-2.5	-0.1	-2.6	-1.5
Medication: Bendroflumethiazide	2.5	3.8	12.3	2.6	2.0	2.3	-1.2	1.6	1.4	0.7	3.5	2.0	2.5	-0.1	1.9	-0.0
Qualifications: CSEs or equivalent	2.4	3.2	8.7	1.4	1.8	3.0	-1.7	1.0	2.1	-0.7	2.5	1.9	2.2	-1.5	1.2	-0.6
Illnesses of mother	2.4	3.0	7.7	-2.4	-2.4	-0.5	-1.3	-2.8	0.7	-1.0	-0.7	-0.9	-1.9	-1.6	-2.6	-1.5
Risk taking	2.3	3.4	9.7	-0.1	-0.1	1.9	-3.1	-0.5	2.5	-1.4	1.9	1.7	1.2	-2.8	-1.6	-1.9
Ulcerative Colitis (UC)	2.2	4.2	14.3	1.3	0.5	-1.7	3.8	1.8	-2.7	-0.0	-0.0	-1.4	-0.7	3.3	2.5	2.1
Fasting Glucose	2.2	2.6	6.6	0.9	1.0	-1.1	2.5	1.1	-2.0	2.6	-0.8	-1.2	-0.8	1.7	1.6	2.2
Type 2 Diabetes (T2D) (2012)	2.2	2.5	9.3	1.6	1.2	2.0	-0.1	1.0	1.5	0.2	2.3	0.1	2.5	0.2	3.1	-0.1
Systolic blood pressure, automated reading	2.2	6.4	12.0	3.2	3.5	1.9	-0.2	3.4	0.1	3.2	2.5	1.6	2.5	1.3	3.5	2.6
Tinnitus: Yes, but not now, but have in the past	2.2	2.4	5.0	0.8	1.4	1.9	-0.4	1.3	1.8	1.0	2.1	2.2	2.1	0.3	2.0	-0.5
Medication: Ramipril	2.2	2.9	6.8	2.6	1.6	-0.0	1.5	1.8	-1.2	2.5	0.1	0.7	1.0	1.6	2.2	2.4
Pain type(s) experienced in last month: Hip pain	2.2	2.7	8.1	-0.7	-0.3	2.3	-2.3	-1.0	2.8	-0.9	1.3	0.1	1.7	-2.4	-0.0	-2.1
Myopia	2.2	3.2	6.8	0.2	-0.6	-2.2	2.1	0.3	-2.4	1.7	-2.6	-2.6	-1.8	1.8	0.4	1.9
Systolic Blood Pressure	2.1	10.5	21.0	4.6	4.5	3.6	-1.1	4.0	1.2	2.7	3.2	1.9	4.4	0.3	4.2	2.4
Heel bone mineral density (BMD) T-score, automated (right)	2.1	4.8	16.0	-0.1	1.1	2.5	-4.0	-0.1	2.0	-2.1	-0.7	3.2	0.9	-3.3	-2.7	-0.9
Mouth/teeth dental problems	2.1	3.2	7.3	0.0	-0.2	-2.1	2.5	0.6	-2.5	1.5	-2.3	-1.7	-1.7	2.7	0.9	1.9
Illnesses of siblings	2.1	2.9	9.2	-1.8	-1.7	-1.7	-0.2	-1.7	-1.2	-0.7	-2.4	-0.7	-2.8	-0.8	-3.0	-0.1
Glaucoma (self-reported)	2.1	2.4	7.7	0.9	1.3	-0.2	1.7	1.9	-1.0	2.2	0.7	1.0	0.6	2.2	2.8	1.6
Medication: Paracetamol	2.1	3.2	10.0	-0.1	-0.1	2.1	-1.6	-0.3	2.7	0.1	3.2	2.5	2.4	-1.0	1.1	-1.8
Irritability	2.1	3.5	10.5	-0.4	0.2	2.5	-2.1	-0.9	3.0	-0.6	0.3	3.2	2.3	-2.4	0.0	-1.8
Neuroticism (Nagel 2018)	2.0	4.8	15.4	-0.3	-0.1	2.9	-2.3	-1.3	3.9	-0.4	1.2	2.8	3.1	-1.7	0.9	-3.0
Reaction Time	2.0	3.9	10.8	-3.1	-2.9	-1.2	-0.8	-3.3	0.8	-1.7	-0.2	-0.2	-2.0	-1.2	-2.5	-1.9
Breast Cancer	2.0	4.9	12.0	-2.8	-3.5	-3.2	2.0	-1.9	-1.6	-0.1	-1.6	-2.6	-3.2	1.1	-1.6	-0.9
Crohns Disease (2012)	2.0	3.2	7.6	-0.0	-1.1	-2.4	2.0	0.0	-2.8	-0.7	-1.6	-2.7	-2.5	1.0	-1.0	1.8
Blood White Count	2.0	14.6	40.6	3.2	3.0	-2.2	4.7	4.4	-5.0	4.3	-1.1	-1.0	-0.9	4.8	3.8	6.4
Neuroticism	2.0	4.9	13.8	-1.6	-1.0	1.9	-2.5	-2.4	3.7	-1.2	0.3	2.9	2.2	-2.1	-0.5	-3.5
Pulse wave Arterial Stiffness index	2.0	2.3	6.1	1.5	1.7	1.7	-1.1	1.2	1.3	0.3	1.9	2.4	2.5	-0.1	1.3	0.1
Heart disease (mother)	2.0	2.5	8.5	2.2	2.0	1.7	-0.7	2.2	1.0	-0.4	1.6	-0.0	2.9	-0.7	1.4	0.2
Qualifications: nursing, teaching	2.0	3.2	8.7	-1.1	-1.4	-3.0	2.4	-0.8	-2.4	0.7	-1.5	-1.1	-2.9	2.0	-0.8	0.9
Commuting to job workplace: Walk	2.0	2.1	5.7	1.1	0.2	-1.4	1.9	0.8	-1.8	2.4	-0.0	-1.4	-0.6	2.0	1.4	1.8
Vascular/heart problems diagnosed by doctor	2.0	5.4	13.2	-2.9	-2.3	-2.1	0.3	-1.7	-1.2	-2.0	-3.2	-2.6	-3.5	-1.0	-3.6	-0.8
Hand grip strength (left)	1.9	4.9	11.3	1.6	1.3	-1.8	2.9	2.3	-3.4	1.3	-2.6	-1.8	-1.1	2.7	1.2	3.0
High blood pressure	1.9	5.3	13.8	3.1	2.5	1.8	0.1	2.0	0.5	2.4	2.8	2.3	2.9	1.2	3.7	1.6
Diabetes (self-reported)	1.9	2.9	11.3	1.0	0.9	-0.0	2.0	1.7	-0.6	2.6	0.2	-1.0	0.9	2.5	3.4	1.3
Forced expiratory volume in 1-second (FEV1)	1.9	6.4	34.3	0.2	0.3	-0.4	-2.8	-0.5	-1.2	-4.1	-1.4	-0.4	-1.8	-4.1	-5.9	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.9	5.9	29.5	-0.4	-0.1	-0.2	-2.7	-0.7	-0.8	-4.2	-1.3	-0.6	-1.6	-4.0	-5.4	-0.2
Headache pain in last month	1.9	3.3	8.5	-0.8	-0.7	1.8	-2.4	-1.1	2.9	-1.3	1.7	2.2	1.7	-2.1	-0.7	-2.5
Migraine (self-reported)	1.9	2.4	7.8	-0.7	-1.7	1.0	-1.5	-1.8	2.3	-1.8	0.7	-0.0	0.5	-1.8	-1.2	-2.8
Diabetes diagnosed by doctor	1.9	3.0	12.7	1.8	1.3	0.3	1.9	1.8	-0.5	1.8	0.5	-0.5	1.7	2.6	3.6	1.1
Heart disease (siblings)	1.9	2.4	10.3	1.1	0.3	-0.1	2.5	1.0	0.1	0.6	2.0	-0.2	1.5	2.4	3.2	0.3
Bipolar Disorder or Schizophrenia	1.8	4.3	10.5	-1.3	-2.4	-3.2	1.4	-1.4	-1.8	-1.2	-2.7	-2.8	-2.7	1.0	-2.4	-0.5
Ulcerative Colitis	1.8	2.7	8.1	1.2	0.2	-1.6	2.8	1.1	-2.3	0.4	0.2	-1.7	-0.7	2.3	1.7	2.0
Lung FVC	1.8	9.1	27.5	1.0	0.8	-3.6	1.7	1.5	-5.2	-0.0	-3.5	-3.6	-4.5	1.5	-2.9	3.8
Number of incorrect matches in round	1.8	3.1	9.9	-0.7	-1.1	-2.9	3.2	-0.1	-2.3	-0.1	-0.5	-1.3	-2.1	2.6	0.8	0.8
Blood clot in the leg (DVT)	1.8	2.3	6.9	1.1	0.8	-1.5	1.7	1.4	-2.6	1.0	-0.7	0.4	-1.2	1.9	0.8	2.5
Pulse wave peak to peak time	1.8	2.1	5.8	-1.1	-1.3	-1.8	1.2	-0.8	-1.6	-0.4	-1.8	-2.3	-2.4	0.2	-1.3	0.3
Hypertension (Self-reported)	1.8	5.0	11.4	3.0	2.3	1.9	-0.2	1.7	0.7	2.2	3.0	2.5	3.1	0.9	3.4	1.4
Age started oral contraceptive pill	1.8	2.2	6.0	0.2	0.1	-2.2	2.2	0.8	-2.4	1.1	0.3	-1.3	-1.3	2.4	0.4	1.7
Deep venous thrombosis (DVT) (self-reported)	1.8	2.3	6.9	1.1	0.8	-1.5	1.7	1.4	-2.6	0.9	-0.7	0.6	-1.2	2.1	0.7	2.5
HbA1C	1.7	1.9	4.9	1.4	1.3	1.8	0.7	0.9	1.7	1.0	1.8	0.4	2.2	0.1	2.0	0.2
Type 2 Diabetes (T2D) (2018)	1.7	3.2	11.2	1.9	1.4	0.4	1.9	2.5	-0.7	1.6	-0.0	-1.3	1.2	2.6	3.4	1.4
Medication: Co-codamol	1.7	2.0	4.6	1.6	1.9	1.4	-0.5	2.1	0.5	2.1	0.1	0.7	1.7	0.5	1.8	1.0
High blood pressure (mother)	1.7	2.4	6.7	2.1	2.6	1.6	-0.3	2.2	0.3	0.4	1.4	1.9	1.9	0.2	1.5	1.1
Wheeze or whistling in the chest in last year	1.7	3.1	10.2	1.1	1.0	2.3	-1.1	0.5	2.4	0.8	1.5	3.2	2.6	0.1	2.4	-0.7
Eye problems/disorders: None of the above	1.7	2.0	7.2	-0.4	-0.9	-0.0	-1.5	-1.6	0.6	-2.1	-1.4	-0.6	-0.2	-2.1	-2.7	-1.1
Number of full sisters	1.7	2.0	5.8	0.3	0.9	1.6	-2.4	-0.0	1.6	-1.5	0.6	1.6	1.5	-2.0	-1.1	-1.3
Commuting to job workplace: Car/motor vehicle	1.7	1.9	5.1	0.7	0.4	2.2	-1.9	-0.1	2.3	-1.0	1.0	1.1	1.6	-1.8	0.0	-1.4
Supplements: Fish oil (including cod liver oil)	1.7	2.3	5.0	-1.0	-1.9	-1.7	0.1	-1.7	-0.8	-1.6	-0.9	-2.2	-2.2	-0.4	-2.2	-0.6
Impedance of whole body	1.7	8.8	21.3	-2.8	-2.3	2.2	-3.3	-2.8	3.9	-3.9	1.6	1.1	0.8	-3.8	-2.7	-4.6
Leg fat mass (left)	1.7	6.6	15.4	3.9	3.6	0.6	0.1	3.2	-1.8	2.7	1.4	2.8	2.1	1.3	2.3	3.9
Impedance of leg (right)	1.6	7.8	17.5	-2.2	-1.4	2.6	-3.6	-2.4	4.0	-3.0	1.7	2.0	1.1	-3.6	-2.3	-4.2
Medication: Atenolol	1.6	1.9	4.8	1.1	0.8	2.1	-0.8	0.6	2.2	-0.3	1.8	1.2	2.0	-0.7	1.6	-1.2
Had menopause	1.6	2.0	7.1	0.3	-0.4	-2.7	1.4	-0.4	-2.5	-0.1	-1.6	-0.1	-1.7	1.1	-1.3	1.5
Fluid intelligence score	1.6	3.2	8.2	-2.1	-2.2	-0.1	-1.5	-2.6	0.9	-1.7	-0.0	-0.9	-1.5	-2.3	-2.9	-1.9
Impedance of arm (right)	1.6	7.5	17.8	-2.6	-2.0	2.0	-2.9	-2.4	3.6	-3.7	1.2	1.2	1.1	-3.6	-2.5	-4.2
Medication for cholesterol, blood pressure or diabetes	1.6	2.6	8.1	-2.0	-2.0	-1.3	-0.3	-1.8	-0.5	-2.1	-1.2	-0.1	-2.3	-0.9	-2.8	-1.0
Medication: Ventolin 100micrograms inhaler	1.6	2.0	7.3	0.4	0.4	-1.1	1.5	1.1	-1.4	2.1	-2.7	-0.9	-1.0	2.0	0.8	1.2
Medication: Ibuprofen	1.6	2.0	5.7	1.4	1.4	1.6	-1.1	1.6	0.8	1.1	2.4	1.7	1.6	-0.2	1.0	0.9
Arm predicted mass (right)	1.6	8.2	25.9	4.3	3.4	-1.3	2.0	3.8	-4.0	1.9	-0.4	0.7	0.1	2.5	1.8	5.1
Irritable Bowel Disease (IBD)	1.5	3.7	11.2	1.5	-0.1	-2.1	3.3	1.5	-2.8	-0.9	0.4	-1.8	-1.1	2.7	1.6	2.1
Exposure to tobacco smoke at home	1.5	1.7	5.1	-2.3	-2.1	-1.3	0.3	-2.0	-0.1	0.1	-0.9	-1.2	-1.3	-0.2	-1.5	-1.0
Arm fat-free mass (right)	1.5	7.6	24.6	4.1	3.2	-1.4	2.0	3.5	-4.0	1.7	-0.6	0.8	0.0	2.5	1.6	5.0
Whole body fat mass	1.5	6.1	15.6	4.0	3.6	1.0	-0.3	3.1	-1.3	1.9	1.8	3.0	2.5	0.7	2.0	3.3
Leg fat mass (right)	1.5	5.8	14.4	3.8	3.5	0.9	-0.2	3.0	-1.3	2.3	1.5	3.0	2.3	0.9	2.0	3.3
Age at last live birth	1.5	2.2	6.4	-1.2	-1.4	-2.2	2.5	-0.7	-1.3	-0.3	-1.8	-1.2	-1.7	2.0	-0.1	-0.0
Knee pain experienced in last month	1.5	2.4	8.0	-1.1	-0.7	-2.4	0.2	-0.8	-1.7	-0.9	-1.8	-1.4	-2.3	-0.6	-2.8	0.7
Medication: Lisinopril	1.5	1.9	4.7	1.5	2.2	1.5	-0.4	1.8	0.2	1.3	1.4	-0.1	1.7	0.3	2.0	1.0
Leg fat percentage (left)	1.5	5.3	10.9	3.3	3.3	1.4	-0.9	2.5	-0.5	2.6	2.0	2.9	2.5	0.5	2.2	2.7
Neuroticism (2016)	1.4	2.0	5.9	0.9	1.2	2.0	-1.2	0.6	1.8	0.0	1.4	2.4	2.2	-0.7	1.2	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.1	9.9	-0.3	0.9	2.0	-3.0	-0.2	1.4	-1.4	-1.2	3.1	0.8	-2.5	-2.0	-0.3
Weight	1.4	7.1	20.8	4.4	3.7	-0.1	0.8	3.5	-2.8	2.1	0.5	2.0	1.7	1.6	2.0	4.6
Time employed in main current job	1.4	1.6	5.1	1.0	0.5	-1.3	1.6	1.2	-1.6	1.5	0.1	-0.4	-0.3	2.3	1.4	1.3
Impedance of arm (left)	1.4	6.5	17.1	-2.6	-2.3	1.5	-2.3	-2.5	3.2	-3.6	1.4	1.0	0.6	-3.1	-2.3	-4.1
Medication: Paracetamol	1.4	2.3	9.8	-0.3	-0.1	1.6	-0.7	-0.0	2.1	0.6	3.1	2.0	1.9	-0.4	1.6	-1.3
Number of full brothers	1.4	1.8	4.3	-0.2	0.8	2.1	-1.2	0.4	2.0	-1.2	1.6	1.1	1.8	-1.4	0.5	-1.4
Medication: Allopurinol	1.4	1.9	4.3	1.1	1.2	-0.0	1.4	1.9	-0.9	1.9	0.1	1.0	0.8	1.9	2.1	1.7
Mean time to correctly identify matches	1.4	2.7	7.6	-2.2	-2.6	-2.1	0.4	-2.8	-0.6	-1.0	-0.4	0.2	-2.3	0.1	-1.8	-0.9
Leg fat-free mass (right)	1.4	7.6	25.1	3.8	3.0	-1.6	2.4	3.5	-4.1	1.9	-0.9	0.5	0.1	2.5	1.7	5.0
Leg predicted mass (right)	1.4	7.7	25.5	3.8	3.0	-1.6	2.4	3.5	-4.2	1.9	-1.0	0.5	0.1	2.5	1.7	5.0
Basal metabolic rate	1.4	7.6	25.2	4.2	3.5	-0.9	1.6	3.7	-3.7	1.8	-0.5	1.3	0.7	2.0	1.6	5.0
Heel T-Score	1.3	10.5	30.4	-1.9	0.8	2.2	-5.3	-0.7	1.6	-2.9	-4.0	3.1	-0.7	-5.5	-5.5	-0.7
Allergy or Eczema	1.3	3.4	10.9	-1.1	-0.9	-2.7	1.6	-0.1	-2.7	1.4	-2.4	-1.0	-3.3	1.1	-1.4	1.7
Leg fat-free mass (left)	1.3	6.6	20.8	3.8	3.1	-1.1	1.9	3.4	-3.6	1.6	-0.5	1.0	0.6	2.2	1.6	4.6
Age when periods started (menarche)	1.3	3.2	9.0	0.7	1.1	-1.8	1.1	1.6	-3.0	1.7	-2.0	-1.4	-1.8	1.6	-0.6	2.9
Leg predicted mass (left)	1.3	6.8	21.3	3.9	3.2	-1.1	1.9	3.5	-3.6	1.6	-0.5	1.1	0.7	2.1	1.6	4.6
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.4	3.5	0.4	0.5	1.7	-1.9	-0.1	1.8	-0.8	1.1	1.4	1.5	-1.3	-0.2	-1.1
Breastfed as a baby	1.3	1.6	4.2	0.8	0.2	-1.7	2.1	0.7	-2.0	0.8	-0.7	-0.8	-0.7	1.8	0.6	1.5
Tense / ‘highly strung’	1.3	2.2	6.0	-2.2	-2.1	-0.6	-0.4	-2.3	1.2	-0.1	-2.5	0.6	-0.7	-0.4	-1.3	-1.9
Gout (self-reported)	1.3	1.8	5.2	1.2	1.3	0.4	1.3	2.3	-0.6	1.6	0.5	-0.3	1.0	1.4	2.1	1.6
Leg fat percentage (right)	1.3	4.8	10.2	3.0	3.1	1.8	-1.3	2.1	0.2	1.9	2.4	3.2	2.8	-0.0	1.8	1.9
Whole body fat-free mass	1.3	7.5	24.7	4.0	3.2	-1.4	2.0	3.5	-4.0	1.6	-0.9	0.8	0.2	2.3	1.4	5.0
Whole body water mass	1.3	7.7	25.5	4.1	3.3	-1.3	2.0	3.6	-4.1	1.7	-1.0	0.7	0.2	2.3	1.4	5.1
Wears glasses or contact lenses	1.3	1.5	4.5	0.1	-0.4	-2.1	1.3	-0.3	-2.1	0.3	-1.3	-0.4	-1.8	1.2	-0.8	1.2
Commuting to job workplace: Cycle	1.3	1.5	3.7	-0.9	-0.7	-1.9	1.9	-0.1	-1.4	1.2	-1.0	-1.0	-1.2	1.9	0.5	0.7
Arm predicted mass (left)	1.3	6.4	22.2	3.8	3.3	-1.0	1.4	3.4	-3.6	1.4	-0.7	0.9	0.3	1.7	1.1	4.7
Blood Platelet Count	1.2	13.5	35.5	-0.5	1.4	-3.9	4.0	3.0	-5.3	6.0	-2.4	-1.9	-4.0	4.2	1.1	4.9
Number of treatments/medications taken	1.2	2.2	5.6	1.4	1.5	0.8	0.1	1.5	0.2	2.4	1.4	1.7	2.0	1.3	2.3	0.7
Medication for hormone replacement therapy	1.2	1.3	7.6	-0.7	-0.7	-0.8	-0.2	-0.9	-0.4	-0.7	-2.8	0.7	-1.7	-0.1	-1.6	-0.4
Townsend deprivation index at recruitment	1.2	1.7	5.0	-0.1	-0.6	1.2	-1.7	-1.2	2.2	-0.1	0.4	2.2	1.4	-1.3	-0.2	-1.6
Relative age voice broke	1.2	1.8	4.7	0.4	0.7	-1.5	1.4	0.9	-2.2	1.7	-0.7	0.9	-0.3	2.1	1.2	1.7
Taking other prescription medications	1.2	1.9	5.1	1.1	1.4	0.1	0.9	1.3	-0.5	2.3	0.2	1.6	1.6	1.6	2.2	0.9
Trunk fat mass	1.2	5.3	14.0	3.7	3.3	0.8	-0.4	2.9	-1.4	1.5	1.9	3.0	2.3	0.6	1.6	3.1
Had other major operations	1.2	1.5	6.9	-1.2	-0.7	-1.7	1.6	-0.0	-1.3	0.1	-2.6	0.7	-1.1	1.1	-0.6	0.4
Heart attack	1.2	1.6	6.0	1.7	1.4	1.0	-0.3	0.9	0.7	-1.0	1.8	1.2	2.5	-0.1	1.2	-0.1
Trunk fat-free mass	1.2	7.1	24.2	4.1	3.2	-1.3	1.7	3.4	-4.0	1.5	-1.1	0.8	0.1	2.0	1.1	4.9
Frequency of tiredness / lethargy in last 2 weeks	1.2	1.9	6.2	1.3	1.1	1.5	-0.2	1.0	1.2	1.5	0.6	1.9	2.5	0.2	2.2	0.6
Arm fat mass (right)	1.2	4.9	12.1	3.5	3.2	1.0	-0.3	2.7	-0.9	1.8	1.6	2.8	2.6	0.5	2.0	2.9
Trunk predicted mass	1.2	6.8	23.3	4.0	3.2	-1.3	1.7	3.3	-3.9	1.4	-1.1	0.7	-0.0	2.0	1.0	4.8
Peak expiratory flow (PEF)	1.2	2.7	11.4	0.8	0.7	0.1	-1.9	-0.3	-0.4	-3.2	-0.5	0.0	-0.2	-2.8	-3.4	0.2
Chronic bronchitis/emphysema (mother)	1.2	1.4	5.2	1.3	1.2	0.6	0.6	1.3	-0.1	1.8	0.5	0.4	0.8	1.2	2.3	1.3
Body fat percentage	1.2	4.5	10.4	3.0	2.9	1.5	-1.1	2.2	-0.2	1.5	2.4	3.2	2.8	-0.0	1.7	2.1
Health satisfaction	1.2	1.5	6.2	0.4	0.8	-0.1	1.3	1.1	-0.5	2.5	0.1	0.2	0.4	1.4	2.3	1.4
Suffer from ‘nerves’	1.2	1.9	7.6	-0.7	-0.5	1.9	-1.5	-1.0	2.8	-0.5	0.6	-0.4	1.5	-0.9	0.4	-2.3
Arm fat mass (left)	1.2	5.0	13.2	3.6	3.2	0.7	-0.1	2.7	-1.3	1.8	1.5	2.6	2.4	0.8	1.9	3.1
Arm fat-free mass (left)	1.2	6.1	21.8	3.7	3.2	-1.1	1.3	3.2	-3.7	1.2	-1.0	0.9	0.2	1.6	0.8	4.7
Worry (Nagel 2018)	1.1	2.2	8.4	-2.0	-1.2	1.0	-1.1	-2.0	2.6	-0.5	0.0	0.7	1.1	-0.7	-0.0	-2.9
Diabetes (father)	1.1	1.3	5.2	1.6	0.8	0.6	0.9	1.2	-0.1	1.2	0.3	0.5	1.0	1.4	2.3	1.0
Impedance of leg (left)	1.1	5.2	10.5	-1.9	-1.2	2.3	-3.2	-2.0	3.2	-2.2	1.3	1.6	0.7	-3.0	-1.8	-3.2
Waist circumference	1.1	4.1	9.9	3.1	2.5	1.4	-0.7	1.9	0.1	1.6	2.2	2.9	2.7	0.5	2.1	1.7
Hearing difficulty/problems with background noise	1.1	1.8	6.1	-0.4	-0.5	-1.6	2.5	0.2	-1.2	1.2	-1.2	-0.6	-0.3	2.4	1.7	0.6
Hair/balding pattern: Pattern 2	1.1	1.4	5.2	1.1	1.7	1.8	-0.8	0.7	1.4	0.0	1.2	0.6	2.3	-0.6	1.0	-0.3
Forced vital capacity (FVC)	1.1	4.3	13.6	2.2	1.7	-1.6	0.3	2.1	-3.7	-1.3	-1.9	-1.2	-1.9	-0.4	-2.4	3.4
Medication: Cholesterol lowering	1.1	1.7	4.3	0.7	0.4	-0.9	2.0	0.8	-1.0	1.7	0.3	-1.4	0.3	2.1	2.1	0.8
High blood pressure (siblings)	1.1	1.6	4.1	1.2	1.3	1.9	-0.6	1.1	1.3	0.8	1.3	0.3	2.0	-0.0	2.0	0.1
Long-standing illness, disability or infirmity	1.1	1.6	6.4	0.3	0.0	-0.4	1.7	0.4	-0.2	2.1	-1.1	0.5	0.7	2.2	2.5	0.2
Heart attack/myocardial infarction (self-reported)	1.1	1.5	5.4	1.8	1.5	0.9	0.0	1.1	0.5	-0.6	1.6	0.9	2.3	0.2	1.4	0.1
Trunk fat percentage	1.0	4.1	10.6	2.9	2.7	1.5	-1.2	2.0	-0.1	0.9	2.5	3.3	2.7	-0.3	1.4	1.7
Maternal smoking around birth	1.0	1.5	4.9	1.9	2.2	1.3	-1.1	1.4	0.2	0.1	0.4	1.3	1.5	-0.7	0.5	1.0
Body mass index (BMI)	1.0	4.4	10.3	3.2	2.9	0.5	0.2	2.5	-1.2	2.7	1.1	1.8	2.0	1.2	2.3	3.0
Allergy	1.0	2.3	5.1	-0.1	0.0	1.9	-2.0	-0.7	2.2	-1.7	1.4	0.2	2.0	-2.1	-0.6	-1.9
Arm fat percentage (right)	1.0	4.1	9.5	2.7	2.6	1.7	-1.2	1.8	0.3	1.3	2.3	3.1	3.1	-0.3	1.7	1.6
Worrier / anxious feelings	1.0	1.9	5.8	-2.4	-1.1	0.3	-0.6	-1.8	1.8	-0.8	0.7	1.5	0.1	-1.0	-0.9	-2.4
Hair/balding pattern: Pattern 4	1.0	2.4	5.6	1.5	0.9	-1.0	2.2	1.9	-2.4	1.4	0.2	-0.4	-0.4	2.0	1.4	2.2
Qualifications: O levels/GCSEs or equivalent	1.0	1.7	4.6	2.1	1.8	0.5	0.5	1.8	-0.9	1.3	0.2	0.8	0.8	0.4	1.3	2.1
Forced vital capacity (FVC), Best measure	1.0	3.5	10.2	1.4	1.1	-1.4	0.2	1.5	-3.2	-1.6	-2.1	-1.9	-2.0	-0.6	-2.5	2.6
Leg pain on walking	1.0	1.3	4.3	-0.4	0.0	-1.6	1.4	0.0	-1.8	0.6	-2.1	-0.4	-0.8	1.3	-0.2	1.1
Arm fat percentage (left)	1.0	3.9	8.5	2.8	2.6	1.4	-0.8	1.9	-0.1	1.5	2.2	2.9	2.7	0.0	1.8	1.8
Number of self-reported non-cancer illnesses	1.0	1.7	6.2	0.9	1.0	-0.1	1.2	1.1	-0.2	2.0	0.2	0.7	1.5	2.1	2.5	0.4
Illnesses of father: High blood pressure	1.0	1.2	3.0	-1.3	-1.4	0.2	-0.9	-1.4	1.3	-1.4	0.5	-0.3	-0.0	-1.3	-1.0	-1.7
Unable to work because of sickness or disability	1.0	1.3	2.8	-0.4	-1.0	-1.4	1.6	-0.5	-1.1	1.5	-1.4	-1.1	-0.3	1.7	1.0	0.7
Schizophrenia (2018)	0.9	1.8	6.4	-0.3	-0.8	-2.0	1.5	-0.1	-1.6	-0.3	-2.5	-1.4	-1.4	1.3	-1.0	0.6
Schizophrenia (2014)	0.9	2.1	5.3	-0.9	-1.6	-2.1	1.1	-1.1	-1.0	-1.0	-2.3	-1.7	-1.6	0.9	-1.6	-0.5
Triglycerides	0.9	1.4	3.6	0.5	1.4	1.9	-0.8	0.7	1.6	0.4	1.6	0.7	1.8	-1.1	1.3	-0.3
Chronotype (morning person)	0.9	2.1	8.5	-1.2	-0.8	1.3	-0.6	-1.3	2.7	-0.6	0.3	0.9	1.6	-0.3	1.1	-2.9
Ever had hysterectomy (womb removed)	0.9	1.0	2.6	1.5	1.6	1.2	-0.3	1.5	0.4	0.7	0.4	0.0	1.3	0.1	1.5	0.6
Vitamin and mineral supplements	0.9	1.2	4.9	0.7	1.0	1.1	-0.4	0.5	0.9	0.2	1.8	2.2	1.8	-0.5	0.8	-0.2
Medication: Lansoprazole	0.9	1.1	3.7	0.2	0.7	1.1	-1.8	0.1	0.8	0.2	0.5	1.9	1.2	-1.5	-0.4	-0.3
Length of working week for main job	0.9	0.9	2.6	-0.2	-0.6	-1.3	1.0	-0.1	-1.5	0.0	-0.4	-1.5	-1.6	1.1	-0.2	0.7
Birth weight of first child	0.9	1.7	4.2	1.1	0.8	-1.1	1.5	1.4	-1.6	0.6	-0.5	-1.9	0.2	2.0	1.4	1.3
Overall health rating	0.9	1.9	7.2	0.9	0.7	0.7	0.6	1.4	0.6	2.6	0.6	1.2	1.4	1.4	2.7	0.5
Average weekly red wine intake	0.9	1.3	4.3	1.2	0.4	-1.5	1.6	0.7	-2.1	0.2	-0.7	-0.8	-0.2	1.5	0.3	1.3
Tinnitus: Yes, now most or all of the time	0.9	1.1	3.1	1.3	1.7	0.9	-1.2	1.7	-0.2	-0.9	-0.2	-1.3	0.9	-0.5	-0.5	0.4
Medication: Blood pressure	0.9	1.7	4.4	1.8	1.3	1.3	-1.3	0.9	0.7	1.2	2.1	1.6	1.6	-0.6	1.1	0.5
Ever had prostate specific antigen (PSA) test	0.9	1.1	4.9	-0.3	-0.4	-0.5	-0.8	-1.0	-0.5	-0.8	-2.0	0.9	-0.9	-0.9	-2.2	-0.0
Supplements: Calcium	0.9	1.0	2.3	-1.3	-1.2	-1.5	1.5	-0.9	-0.8	0.3	-1.0	-1.2	-0.8	0.9	-0.2	-0.4
Depression (Nagel 2018)	0.8	1.2	2.9	-0.0	0.5	1.4	-0.5	0.7	1.7	1.3	1.2	0.3	1.4	0.5	1.7	-1.0
Primary Biliary Cirrhosis	0.8	1.2	5.5	0.8	0.4	1.0	-0.7	-0.3	1.3	-0.8	1.4	1.4	2.4	-0.3	0.7	-1.0
Blood Eosinophil Count	0.8	5.8	13.6	1.0	1.8	-1.7	1.7	2.7	-3.4	2.9	-3.7	-1.9	-2.0	2.1	0.5	3.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	4.1	0.1	0.8	0.8	0.3	1.0	0.8	1.8	-0.1	0.5	1.2	1.2	2.0	0.2
Hayfever, allergic rhinitis or eczema	0.8	1.8	6.9	-1.0	-1.3	-2.1	0.8	-0.6	-1.7	0.3	-1.3	-0.6	-2.6	0.5	-1.6	0.7
Qualifications: None of the above	0.8	1.7	4.8	-0.5	-0.2	1.5	-2.2	-0.8	2.0	-0.8	0.7	0.6	1.3	-1.9	-0.7	-1.6
Prospective memory result	0.8	1.0	4.2	-0.5	-0.6	-0.7	1.0	-0.0	-0.5	0.9	-2.0	-1.8	-0.8	0.8	0.1	0.1
Family relationship satisfaction	0.8	0.9	3.7	-1.2	-1.6	-0.2	0.3	-1.5	1.2	-0.4	0.6	0.2	-0.1	0.2	0.2	-1.9
Supplements: Vitamin C	0.8	1.0	3.5	-0.7	-1.0	-0.9	-0.2	-0.6	-0.6	-0.5	-1.9	-0.7	-1.7	-0.1	-1.5	0.0
Illnesses of siblings: Diabetes	0.8	1.0	2.2	1.0	1.2	1.5	0.0	1.5	0.5	0.3	1.5	0.4	1.0	0.3	1.5	0.5
Friendships satisfaction	0.8	1.0	3.0	-1.7	-1.5	-0.2	-0.2	-1.0	1.0	-0.4	0.2	-1.1	-0.3	-0.8	-0.5	-1.7
Mineral and other dietary supplements	0.8	1.0	2.4	0.7	1.2	1.3	-0.0	1.1	0.7	0.3	1.0	1.5	1.6	-0.0	1.5	0.1
Pain experienced in last month	0.8	1.4	5.5	0.1	-0.5	-1.3	1.9	-0.1	-1.6	0.9	-0.7	-0.6	-1.1	2.3	1.0	0.7
Intelligence (Savage-Jansen 2018)	0.7	2.1	4.3	-2.0	-2.1	-1.1	-0.1	-1.6	0.2	-0.5	-0.9	-2.1	-2.0	-0.7	-2.1	-1.1
Crohns Disease (2017)	0.7	1.5	3.4	0.5	-1.2	-1.8	1.4	-0.1	-1.8	-1.8	0.6	-1.2	-1.4	0.8	-0.7	0.9
Ovarian Cancer	0.7	0.9	2.1	1.2	0.9	-0.3	0.3	1.1	-0.9	1.2	1.2	0.5	-0.0	1.1	1.1	1.4
Rheumatoid Arthritis	0.7	0.9	5.0	-0.1	-0.8	-0.0	-0.4	-1.3	1.0	-0.3	2.2	0.8	0.6	-0.3	-0.3	-1.5
Blood Red Count	0.7	7.1	32.6	-0.0	0.8	3.4	-3.0	-0.7	3.9	-1.8	0.2	5.7	2.7	-2.9	-0.2	-1.8
Waist Hip Ratio (WHR)	0.7	3.3	15.8	1.1	0.1	1.8	-1.1	0.2	2.5	0.7	4.0	1.6	2.5	0.1	1.9	-1.5
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.8	-0.7	-0.8	-1.2	1.6	-0.7	-0.8	0.4	-0.4	0.5	-0.4	1.7	1.1	-0.1
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	2.4	-0.1	-0.2	-0.8	1.4	-0.1	-1.0	0.5	-1.0	-0.3	-0.6	1.6	1.2	0.7
Average weekly fortified wine intake	0.7	0.8	2.4	-1.2	-1.5	-0.9	0.2	-1.5	-0.1	-1.0	0.2	0.8	-0.7	-0.3	-1.0	-0.7
Alcohol intake versus 10 years previously	0.7	1.1	3.3	0.5	1.0	1.8	-1.5	0.5	1.4	0.3	0.5	0.8	1.4	-1.1	0.7	-0.3
Falls in the last year	0.7	0.9	3.6	1.1	0.7	0.6	-0.4	0.1	0.6	0.5	1.5	1.2	1.9	0.4	1.2	-0.0
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	3.7	0.3	0.3	1.1	-1.4	0.3	0.9	0.3	1.9	1.4	0.6	-0.8	-0.2	0.1
Medication for pain relief, constipation, heartburn	0.7	1.1	5.3	-0.1	0.3	-0.0	-0.5	-0.3	-0.5	-1.6	-2.3	-0.4	-1.2	-1.1	-1.8	0.2
Loneliness, isolation	0.7	1.0	3.4	0.4	-0.1	1.0	-1.0	-0.5	1.3	-0.5	1.2	1.8	1.4	-0.6	0.2	-1.0
Medication for cholesterol	0.7	1.0	5.5	0.2	-0.0	-0.8	1.6	0.8	-0.9	-0.3	0.6	-2.4	-0.0	1.3	0.8	0.2
Osteoporosis (self-reported)	0.7	0.9	2.5	0.5	0.8	0.0	0.6	0.5	-0.2	1.4	1.0	1.3	1.0	1.3	1.6	0.6
Illnesses of father: None of the above (group 1)	0.7	0.9	2.8	-1.2	-0.7	-0.4	-0.6	-0.9	-0.1	-1.1	-0.4	-1.1	-1.3	-0.9	-1.7	-0.8
Guilty feelings	0.7	1.0	2.4	1.2	1.0	1.1	-0.3	1.1	0.7	1.5	-0.4	1.3	1.2	0.3	1.3	0.5
Eye problems/disorders: Glaucoma	0.7	0.8	1.9	0.2	1.0	-0.0	0.7	1.1	-0.9	1.2	0.7	1.4	0.4	0.7	1.1	1.3
High cholesterol (Self-reported)	0.7	1.2	3.8	0.9	1.1	-0.3	0.7	1.3	-1.1	1.9	1.0	0.1	0.2	0.9	1.1	1.5
Number of operations (self-reported)	0.7	1.0	4.0	-1.0	-0.3	-0.1	-1.2	-1.2	0.8	-0.6	-0.6	2.0	0.7	-0.6	-0.8	-1.6
Fractured/broken bones in last 5 years	0.7	0.9	5.5	0.5	0.1	0.2	0.4	0.2	0.6	0.5	2.3	0.9	1.1	0.8	1.3	-0.7
Diastolic blood pressure, automated reading	0.7	2.2	5.5	1.9	1.4	0.5	0.4	1.5	-0.1	1.7	1.5	2.0	1.7	1.4	2.3	1.2
Ever depressed for a whole week	0.7	0.9	2.5	-1.5	-1.2	-0.6	-0.1	-1.4	0.1	-0.4	-1.1	1.6	-0.2	-0.3	-1.0	-0.5
Alzheimer’s Disease (in father)	0.6	0.6	1.6	1.0	1.3	-0.3	-0.2	1.2	-1.1	1.0	-0.5	-0.4	-0.1	0.1	-0.3	1.1
Cardiovascular Disease	0.6	1.9	5.4	0.8	1.0	2.1	-1.0	0.7	1.7	0.3	2.0	1.3	2.3	-0.9	1.4	-0.5
Respiratory disease	0.6	1.3	3.1	0.7	1.4	0.3	0.9	1.6	-0.5	1.8	-1.3	-0.6	-0.1	1.2	1.6	1.1
Frequency of depressed mood in last 2 weeks	0.6	0.8	3.1	-1.3	-1.1	0.4	-0.5	-0.9	1.6	0.3	-0.7	0.3	0.5	-0.1	-0.0	-1.8
Ever used hormone-replacement therapy (HRT)	0.6	0.8	3.6	1.9	1.1	-0.3	0.3	0.7	-1.1	-0.6	0.6	1.1	0.4	0.8	0.3	0.9
Pack years adult smoking proportion	0.6	0.9	2.6	-1.5	-1.2	-1.0	1.6	-0.6	-0.2	0.4	0.1	-1.2	-0.3	1.2	1.1	-0.3
Current tobacco smoking	0.6	1.0	2.0	1.0	1.3	1.4	-1.1	1.1	0.8	0.6	0.8	1.4	1.0	-0.3	0.9	0.5
Nervous feelings	0.6	1.2	4.9	-1.7	-1.3	-0.0	0.2	-1.6	1.5	0.2	-0.3	0.0	0.4	0.4	0.6	-2.2
Qualifications: A levels/AS levels or equivalent	0.6	1.2	3.3	0.7	-0.2	-1.6	1.4	0.4	-1.8	0.8	0.2	-1.3	-1.2	1.5	0.4	1.3
Asthma	0.6	1.2	3.2	-0.8	-0.3	-1.0	1.4	-0.2	-0.7	1.4	-1.8	-0.9	-1.4	1.6	0.5	0.6
Pulse wave reflection index	0.6	0.8	2.2	0.0	-0.4	0.8	-1.5	-0.4	1.3	-0.7	0.4	-0.3	0.8	-1.4	-0.8	-1.2
Worry too long after embarrassment	0.6	1.1	2.7	-1.0	-1.4	-1.6	1.0	-1.5	-0.8	1.2	-0.7	-0.5	-1.2	0.7	-0.3	0.1
Medication: Omeprazole	0.6	0.7	1.7	-0.8	-0.9	0.5	-0.5	-1.2	1.3	0.3	-0.9	0.5	0.9	-0.5	0.0	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	2.4	0.8	1.2	1.2	-0.9	1.0	0.2	0.1	1.6	0.5	1.1	-0.4	0.5	0.5
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	2.0	-0.9	-1.1	-1.2	1.2	-0.8	-0.9	-0.2	0.4	-0.9	-1.4	0.8	-0.1	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.7	-0.4	0.7	1.3	-1.6	0.4	1.1	0.0	-0.7	-0.0	0.7	-1.3	-0.2	-0.5
Ever had bowel cancer screening	0.6	0.7	2.7	0.5	0.4	0.3	-0.2	0.1	0.4	1.1	0.9	1.6	1.2	0.7	1.3	0.0
Eye problems/disorders: Cataract	0.6	0.7	2.4	-0.7	-0.6	-0.9	1.6	0.2	-0.4	0.8	0.6	-0.7	-0.5	1.5	1.0	-0.0
Asthma (self-reported)	0.6	1.3	3.1	-0.7	-0.2	-1.0	1.6	-0.1	-0.9	1.5	-1.7	-0.9	-1.3	1.8	0.6	0.7
Medication: Atorvastatin	0.6	0.8	1.9	0.1	-0.2	-1.2	1.4	0.2	-0.9	1.3	-0.7	-0.2	0.4	1.3	1.1	0.8
Pack years of smoking	0.6	0.9	2.7	-1.4	-1.1	-1.1	1.6	-0.6	-0.3	0.7	0.1	-1.1	-0.2	1.3	1.2	-0.1
Alzheimer’s Disease (including proxy)	0.5	0.8	2.2	0.1	0.2	-1.2	0.1	0.2	-1.5	-0.4	-1.4	-0.9	-0.9	0.1	-1.5	0.4
Major Depression (MDD)	0.5	0.6	2.3	0.8	-0.1	0.8	-1.5	0.1	0.8	0.3	1.3	-0.4	0.1	-1.1	-0.2	-0.5
Verbal and Numeric Reasoning (VNR)	0.5	1.2	3.9	-1.2	-1.4	0.0	-0.9	-1.5	0.5	-1.2	-0.0	-0.8	-0.8	-1.3	-2.0	-1.0
BMI	0.5	3.2	8.9	3.0	2.5	0.1	0.2	2.2	-1.5	2.0	0.7	1.7	1.1	1.0	1.5	2.8
Height	0.5	9.0	30.6	3.9	3.2	-2.2	1.2	3.6	-5.5	-1.7	-1.6	0.1	-1.2	0.7	-1.9	5.5
Smoking Status	0.5	1.3	3.1	1.5	1.4	1.5	-1.8	1.0	0.7	-0.6	1.1	1.3	1.0	-1.0	-0.1	0.5
Relative age of first facial hair	0.5	1.1	3.9	0.5	0.8	-0.8	0.6	0.6	-1.2	2.0	0.3	1.5	0.1	0.9	0.9	1.5
Supplements: Zinc	0.5	0.5	3.8	0.1	-0.5	-0.2	0.1	-0.1	-0.5	0.8	-2.0	-0.6	-0.9	0.1	-0.4	0.5
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.7	-0.1	-0.4	0.8	-0.9	-0.4	1.3	-1.0	0.7	0.4	1.1	-0.5	-0.1	-1.1
Sitting height	0.5	3.5	10.0	2.3	2.1	-1.1	1.5	2.9	-3.2	-0.7	-1.5	-0.8	-0.2	1.2	-0.0	3.0
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	2.7	-0.2	0.5	0.8	-0.4	0.4	0.5	1.6	-0.2	1.5	0.7	0.1	0.5	0.4
Financial difficulties in last 2 years	0.5	0.7	1.8	0.7	0.9	1.3	-1.0	1.0	0.9	0.2	0.5	1.4	1.0	-0.6	-0.1	0.1
Hip circumference	0.5	2.1	6.1	2.1	1.8	1.4	-1.3	0.9	0.3	-0.2	1.4	2.5	2.1	-1.0	0.4	1.0
Pulse rate	0.5	0.8	2.0	1.1	1.2	1.0	0.0	1.3	0.5	0.3	1.2	0.6	0.9	0.3	1.4	0.3
Noisy workplace	0.5	0.6	2.1	-0.2	-0.4	-1.0	1.5	-0.1	-0.8	-0.2	-0.2	-1.1	0.1	1.4	0.7	-0.0
Ever highly irritable/argumentative for 2 days	0.5	0.5	3.1	0.1	0.5	0.9	-0.2	0.2	0.8	-0.3	-0.4	0.2	1.8	0.3	1.0	-0.8
Loud music exposure frequency	0.5	0.6	1.6	-1.1	-1.3	-0.9	0.0	-0.9	0.3	-0.0	-0.1	-0.2	-0.8	-0.3	-1.0	-1.1
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	2.0	-0.7	-1.0	0.1	-0.2	-1.4	1.2	0.4	0.3	0.8	0.4	-0.2	0.1	-1.3
Emphysema/chronic bronchitis	0.5	0.5	1.4	0.9	0.4	-0.2	0.5	0.3	0.0	0.4	1.1	1.0	1.1	0.7	1.2	0.0
Angina (self-reported)	0.5	0.6	1.3	-0.2	-0.7	0.1	0.3	-0.9	1.0	-1.1	0.4	1.0	1.1	0.0	0.4	-1.1
Medication: Seretide 50 evohaler	0.5	0.5	2.6	0.4	-0.1	-1.0	0.9	0.2	-1.0	0.5	-0.2	-1.6	-0.4	0.8	0.3	0.5
Alcohol intake frequency.	0.5	1.1	6.0	-0.4	-0.1	1.1	-0.8	-0.9	1.5	0.3	0.5	2.4	1.2	-0.4	0.6	-1.1
Comparative height size at age 10	0.5	3.0	8.4	2.9	2.5	-0.3	-0.2	2.5	-2.2	-1.2	-1.4	0.7	0.1	-0.5	-1.1	2.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.7	-1.1	-0.6	-0.4	0.6	-0.4	-0.1	1.7	-1.2	-0.3	-0.4	0.6	0.5	0.2
Smoking status: Current	0.5	0.7	1.7	0.9	1.0	1.2	-1.2	0.8	0.8	0.4	0.9	1.3	0.9	-0.3	0.6	0.2
Ever taken oral contraceptive pill	0.5	0.6	1.7	0.3	0.1	1.3	-1.0	0.1	0.9	-0.9	0.9	0.2	0.9	-1.0	-0.2	-0.6
Basal cell carcinoma (self-reported)	0.5	0.6	4.2	0.7	0.7	-0.0	0.5	0.9	-0.6	0.3	2.1	-0.6	-0.1	0.6	0.6	0.7
Alcohol drinker status: Previous	0.5	0.6	2.6	-0.9	-0.9	-0.1	-0.0	-1.1	0.6	-0.8	-1.6	0.5	-0.0	0.2	-0.1	-1.1
Coronary Artery Disease (CAD)	0.4	0.5	2.0	1.2	0.5	-0.2	-0.2	0.4	0.1	0.3	0.7	0.5	1.4	0.6	1.3	-0.1
Mean Putamen Volume	0.4	0.5	2.7	-0.0	-0.3	-0.4	0.8	-0.3	-0.5	1.7	-0.9	-0.4	-0.5	0.7	0.7	0.6
Severe depression (siblings)	0.4	0.4	1.2	-0.7	-0.4	-1.0	1.1	-0.2	-0.8	0.5	-0.0	-0.5	-0.9	0.7	0.1	0.4
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	0.9	1.0	0.9	0.4	-0.7	0.5	-0.1	0.7	-0.4	0.7	0.5	-0.8	-0.3	0.8
Serious illness, injury or assault to yourself	0.4	0.5	1.6	-1.1	-1.2	-0.8	0.4	-1.3	-0.1	-0.1	-0.3	-0.2	-0.4	-0.1	-0.1	-0.7
Alcohol usually taken with meals	0.4	0.6	1.9	-0.3	-0.5	-1.0	0.3	-0.6	-0.8	-1.4	-1.1	-0.1	-0.9	-0.0	-1.2	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.8	0.0	-0.1	0.9	-0.2	0.3	1.3	1.3	-0.9	-0.5	1.1	0.4	1.3	-0.8
Medication: Simvastatin	0.4	0.6	1.4	0.9	1.0	0.6	-0.1	0.8	0.4	1.1	0.3	0.6	1.1	0.3	1.2	0.2
Father’s age at death	0.4	0.5	1.4	-0.4	-0.6	-1.2	1.0	-0.2	-1.0	-0.9	-0.1	-0.4	-1.1	0.9	-0.4	0.0
Hair/balding pattern: Pattern 3	0.4	0.6	1.3	1.0	0.6	-0.1	0.7	0.8	-0.5	0.8	0.9	0.4	0.3	1.2	1.0	0.8
Happiness	0.4	0.5	1.9	0.0	0.1	0.0	0.4	0.2	0.3	1.1	0.8	-0.8	0.9	0.7	1.4	-0.3
Lung cancer (father)	0.4	0.5	1.9	0.3	0.2	-0.7	0.4	-0.1	-0.7	0.6	-1.4	-1.0	-0.6	0.9	0.2	0.5
Standing height	0.4	4.3	14.2	3.0	2.2	-1.3	1.3	2.7	-3.7	-1.0	-1.0	0.6	-0.4	1.0	-0.6	3.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	2.9	-0.4	-0.4	0.4	-0.9	-1.0	0.5	0.0	-1.7	-0.1	0.0	-0.8	-0.7	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	1.4	0.7	0.4	0.0	0.6	0.9	-0.2	1.0	0.0	-0.7	0.2	0.6	1.2	0.5
Commuting to job workplace: Public transport	0.4	0.5	1.3	-0.1	-0.1	-1.0	1.0	0.1	-0.9	0.7	-0.4	-0.4	-0.7	1.2	0.6	0.7
Average weekly beer plus cider intake	0.4	0.6	3.0	0.2	0.6	-0.0	-0.1	0.8	-0.6	1.7	-0.0	-0.2	-0.6	0.2	0.1	1.7
Cholesterol lowering medication	0.4	0.7	2.5	0.5	0.8	0.6	-0.5	0.3	0.3	1.2	0.9	1.6	0.9	-0.4	0.7	0.8
Alzheimer’s Disease (in mother)	0.3	0.4	1.8	-0.3	-0.7	-0.7	-0.2	-0.6	-0.2	-0.8	-0.6	-0.4	-0.5	-0.3	-1.3	-0.7
Body Mass Index (BMI) (2010)	0.3	0.5	1.3	0.6	0.5	-0.5	0.9	1.1	-0.8	0.4	-0.2	0.2	-0.6	0.7	0.4	1.1
Average weekly spirits intake	0.3	0.4	2.0	0.3	0.3	0.1	0.4	0.4	-0.2	1.4	0.7	-0.1	0.4	0.3	1.1	0.9
Angina	0.3	0.4	1.0	-0.3	-0.6	0.1	0.4	-0.8	0.9	-0.9	0.1	0.8	1.0	0.1	0.4	-1.0
Multivitamins +/- minerals	0.3	0.4	0.9	-0.5	-0.5	0.3	-0.8	-0.4	0.3	-0.4	-0.4	-1.0	-0.7	-0.8	-0.9	-0.3
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.5	-1.1	-1.2	-0.1	0.1	-0.9	0.5	0.2	-0.8	0.0	-0.5	-0.4	-0.5	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	2.2	0.5	0.5	0.6	-1.3	-0.2	0.5	-0.0	-0.1	1.5	0.7	-0.3	-0.2	-0.2
Exposure to tobacco smoke outside home	0.3	0.4	2.2	-0.4	-0.2	-0.5	-0.2	-0.1	-0.5	1.3	-1.5	0.1	-0.5	0.0	-0.5	0.6
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.2	-0.1	0.3	0.5	-0.8	-0.1	0.6	-0.4	0.9	-1.1	0.2	-0.8	-0.3	-0.6
Had major operations	0.3	0.4	0.9	-0.3	-0.1	-0.2	-0.9	-0.7	0.2	-0.4	0.8	0.8	0.8	-0.2	-0.3	-1.0
Medication: Aspirin	0.3	0.4	1.1	-0.2	-0.8	-0.9	0.6	-0.4	-0.2	0.1	1.1	-1.0	-0.4	0.4	0.1	-0.5
Smoking status: Previous	0.3	0.5	1.6	-0.3	-0.5	-0.8	-0.0	-0.5	-0.8	-1.1	-0.7	-0.7	-0.6	-0.6	-1.3	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.9	0.4	0.4	-0.2	0.2	0.9	-1.0	-1.4	-1.2	-0.7	-0.3	-0.4	-0.9	0.7
Handedness (chirality/laterality): Left-handed	0.3	0.3	1.9	-0.6	-0.4	-0.5	0.2	-0.2	-0.1	-1.4	-0.3	0.0	0.2	-0.5	-1.0	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.1	-0.3	0.4	0.7	-0.4	0.0	0.8	1.0	0.8	1.0	0.6	-0.5	0.7	-0.2
Breast cancer (self-reported)	0.3	0.3	1.0	0.2	0.8	-0.1	0.4	0.9	-0.9	-0.4	0.5	-0.1	0.1	0.1	0.2	1.0
Average weekly champagne plus white wine intake	0.3	0.3	0.9	-0.0	-0.8	-0.5	0.4	-0.7	0.3	-1.0	0.5	0.8	-0.3	0.2	-0.0	-1.0
Ever smoked	0.3	0.6	1.8	-0.2	0.1	0.8	-1.3	-0.3	0.7	-1.2	-0.4	0.1	-0.0	-1.3	-0.8	-0.6
LDL Cholesterol	0.2	0.4	1.1	-0.5	0.1	-0.5	1.1	1.0	-0.3	-0.1	0.0	-1.0	-0.5	0.4	0.8	-0.3
Lupus	0.2	0.2	0.8	-0.2	-0.3	0.3	0.1	-0.6	0.5	-0.9	0.5	-0.3	0.3	-0.1	0.0	-0.9
Tanning	0.2	2.4	9.6	-1.0	-1.3	-2.0	1.2	-0.4	-1.3	-1.4	-1.5	-3.1	-2.1	0.9	-1.2	-0.7
Supplements: Glucosamine	0.2	0.2	0.8	-0.2	-0.1	-0.6	-0.1	-0.3	-0.8	-0.3	-0.1	-0.3	-0.6	-0.0	-0.9	0.7
Depression (self-reported)	0.2	0.3	0.8	-0.4	-0.6	0.3	-0.3	-0.8	0.8	-0.5	-0.5	0.1	0.3	-0.1	0.0	-0.9
Shortness of breath walking on level ground	0.2	0.3	0.8	-0.9	-0.6	0.3	-0.3	-0.6	0.7	0.2	0.1	0.5	0.1	-0.7	-0.2	-0.6
Neck or shoulder pain in last month	0.2	0.2	0.7	-0.5	-0.2	-0.4	0.4	0.6	-0.2	0.6	-0.4	-0.8	-0.6	0.5	0.3	0.1
Chest pain or discomfort	0.2	0.3	1.3	-0.1	-0.4	-0.2	0.9	-0.1	0.1	0.1	1.2	0.6	0.2	0.6	1.1	0.0
Illnesses of father: Heart disease	0.2	0.3	1.8	0.3	-0.0	0.7	0.1	-0.1	0.5	-0.4	0.8	-0.1	1.4	-0.5	0.6	-0.2
Medication: Aspirin	0.2	0.3	1.7	0.0	-0.7	-0.7	0.5	-0.4	-0.1	-0.1	1.3	-0.7	0.1	0.4	0.1	-0.5
Financial situation satisfaction	0.2	0.2	0.8	0.1	0.0	0.6	-0.2	-0.0	0.9	-0.2	0.5	-0.2	0.5	0.3	0.4	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	1.1	-0.3	-0.4	0.1	0.4	-0.5	0.4	0.9	-1.0	0.2	0.5	0.4	0.7	-0.4
Schizophrenia vs Biploar Disorder	0.1	0.1	0.5	-0.3	0.0	0.2	0.1	-0.0	-0.0	-0.7	-0.4	-0.1	-0.3	0.1	-0.3	0.1
Past tobacco smoking	0.1	0.1	0.3	-0.3	-0.2	0.3	0.3	-0.1	0.6	0.5	0.3	0.2	0.0	0.3	0.5	-0.4
Pulse rate, automated reading	0.1	0.4	2.4	-0.4	0.1	0.7	0.5	-0.0	1.0	0.9	-0.6	0.3	-0.1	0.4	1.6	-0.2
Hair Pigment	0.0	0.4	1.6	0.9	0.6	-0.6	-0.7	0.1	-0.5	1.3	-0.4	1.0	0.1	0.1	-0.4	0.4

Hub : Genes

ASCC2

Models

Trait associations