TWAS
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Models
Genes
Traits
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Traits
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Forced expiratory volume in 1-second (FEV1)
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chr2:241,805,851-243,048,760
Best TWAS P=3.04e-17 · Best GWAS P=1.03e-14 conditioned to 0.391
241.8M
242M
242.2M
242.4M
242.6M
242.8M
243M
0
5
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
METSIM
Adipose
BOK
0.06
0.03
lasso
6
0.03
7.8e-06
-7.7
-8.4
3.0e-17
0.95
0.00
1.00
TRUE
1
GTEx
Adipose Visceral Omentum
BOK
0.20
0.12
lasso
4
0.12
1.4e-06
-7.7
-7.4
1.6e-13
0.97
0.00
1.00
FALSE
4
The Cancer Genome Atlas
Prostate Adenocarcinoma
BOK
0.07
0.04
lasso
5
0.03
1.8e-04
6.3
-6.9
4.6e-12
0.76
0.01
0.97
FALSE
3
The Cancer Genome Atlas
Pheochromocytoma and Paraganglioma
BOK
0.19
-0.01
lasso
4
0.01
1.2e-01
-7.7
-5.3
1.4e-07
0.86
0.00
0.76
FALSE