Hub : Genes

BOK

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Visceral Omentum	0.1990	0.0690	2.6e-03	0.124	NA	0.073	NA	0.115	5.5e-07	NA	1.2e-04	NA	1.4e-06
2	GTEx	Cells Transformed fibroblasts	0.1180	0.0420	5.3e-05	0.103	NA	0.104	NA	0.116	3.8e-08	NA	3.1e-08	NA	5.5e-09
3	GTEx	Heart Atrial Appendage	0.1530	0.0610	2.4e-03	0.006	NA	0.078	NA	0.031	1.7e-01	NA	2.1e-04	NA	1.5e-02
4	METSIM	Adipose	0.0610	0.0241	4.2e-04	0.031	0.028	0.017	0.032	0.033	1.6e-05	4.2e-05	9.8e-04	1.4e-05	7.8e-06
5	YFS	Blood	0.0675	0.0188	2.6e-09	0.048	0.033	0.036	0.044	0.046	2.4e-15	5.0e-11	5.0e-12	4.1e-14	9.5e-15
6	TCGA	Pheochromocytoma and Paraganglioma	0.1940	0.0870	1.8e-03	-0.006	0.003	0.001	NA	0.010	7.3e-01	2.3e-01	2.8e-01	NA	1.2e-01
7	TCGA	Prostate Adenocarcinoma	0.0720	0.0306	1.5e-04	0.043	0.024	0.026	NA	0.034	2.6e-05	1.2e-03	8.9e-04	NA	1.8e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.6	0.9	2.9	-1.0	-1.7	-1.1	-1.0	0.2	-0.7	-0.2
Bipolar Disorder or Schizophrenia	0.2	0.4	1.3	0.1	0.0	-0.2	0.5	-1.1	-0.3	1.1
Depressed Affect (Nagel 2018)	0.4	0.8	1.6	-0.9	1.2	0.2	-0.8	1.3	-0.8	-0.6
Depression (Nagel 2018)	0.0	0.1	0.2	0.0	0.3	0.1	-0.1	0.4	-0.3	-0.1
Intelligence (Savage-Jansen 2018)	0.3	0.9	4.5	-0.2	-0.2	0.4	-0.2	2.1	0.8	0.9
Neuroticism (Nagel 2018)	0.5	1.2	2.3	-1.4	0.6	-0.8	-1.4	0.9	-1.5	-0.8
Schizophrenia (2018)	0.7	1.5	2.8	0.9	1.4	0.7	1.4	-1.6	0.2	1.7
Schizophrenia vs Biploar Disorder	0.8	1.1	4.8	0.0	2.2	1.3	0.0	-1.2	0.0	0.0
Worry (Nagel 2018)	1.1	2.4	5.6	-2.0	-0.2	-1.6	-1.8	-0.8	-2.4	-0.8
Alzheimer’s Disease (in mother)	3.1	3.6	5.6	2.0	1.3	1.0	2.3	-2.4	1.6	2.3
Alzheimer’s Disease (in father)	0.8	0.9	1.4	1.1	1.0	0.9	0.9	0.3	0.9	1.2
Alzheimer’s Disease (including proxy)	2.3	3.4	5.2	2.2	1.1	0.9	2.3	-2.2	1.4	2.2
Crohns Disease (2017)	2.8	6.1	10.4	-2.8	-3.2	-2.3	-2.0	-0.4	-3.2	-2.1
Irritable Bowel Disease (IBD)	3.2	7.5	19.7	-3.1	-4.4	-1.1	-2.1	1.1	-3.2	-2.6
Ulcerative Colitis (UC)	1.4	2.6	8.1	-1.6	-2.9	0.4	-0.8	1.1	-1.6	-1.9
Major Depression (MDD)	0.1	0.2	0.9	0.0	0.0	0.9	0.0	-0.1	0.5	0.0
Reaction Time	1.7	3.3	5.2	2.3	0.7	2.1	2.1	0.8	2.1	1.9
Verbal and Numeric Reasoning (VNR)	0.2	0.6	2.2	0.1	-1.5	-0.0	-0.2	0.8	1.0	0.4
Breast Cancer	0.4	0.9	1.8	-0.6	0.8	-1.2	-0.9	-0.1	-1.4	-1.0
Ovarian Cancer	0.3	0.4	1.6	0.4	-0.1	-0.9	0.0	-1.3	-0.1	-0.0
Prostate Cancer	0.1	0.2	0.7	-0.1	-0.8	0.1	-0.2	0.5	0.4	0.0
Age at First Birth	3.3	4.7	8.1	-2.5	-1.8	-1.9	-2.9	0.6	-2.0	-2.8
Bipolar Disorder (2011)	0.3	0.3	1.7	0.0	0.6	-0.4	0.0	-1.3	0.0	0.0
Body Mass Index (BMI) (2010)	0.2	0.2	0.6	0.2	-0.7	-0.1	0.6	-0.7	0.2	0.2
Coronary Artery Disease (CAD)	0.6	0.7	3.6	0.0	-0.1	-0.5	-1.9	-0.9	0.0	0.0
Crohns Disease (2012)	2.8	4.5	16.3	0.0	-2.4	-4.0	-2.8	-1.1	0.0	0.0
Mean Putamen Volume	1.8	2.0	8.8	0.7	-0.2	1.4	0.2	3.0	1.7	-0.1
Fasting Glucose	1.8	2.1	3.5	1.8	1.7	0.5	1.2	-1.9	-0.2	1.8
HbA1C	0.9	1.0	2.1	0.7	-1.4	0.6	1.2	-1.0	0.6	1.2
HDL Cholesterol	0.4	0.6	1.8	-0.6	0.4	-0.7	-1.0	0.1	-0.8	-1.4
LDL Cholesterol	1.4	2.3	4.3	1.3	1.7	0.6	1.5	-2.1	0.8	1.9
Lupus	2.6	3.9	6.9	2.0	1.5	2.1	2.2	1.0	2.1	2.6
Neuroticism (2016)	0.2	0.3	1.1	0.2	0.4	0.2	-0.3	0.7	-0.7	-1.0
Primary Biliary Cirrhosis	0.3	0.4	2.4	0.0	0.1	1.5	0.0	0.8	0.0	0.0
Rheumatoid Arthritis	0.6	0.8	3.0	0.6	1.7	0.9	0.5	-1.0	0.1	0.1
Schizophrenia (2014)	0.3	0.7	2.4	0.0	1.2	0.4	0.6	-1.6	-0.4	0.0
Triglycerides	0.8	1.3	3.3	0.7	0.7	0.4	1.4	-1.8	0.5	1.6
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.7	0.0	0.1	0.0	-0.8	1.3	0.0	0.0
Ulcerative Colitis	1.0	1.5	3.6	-1.7	0.0	-0.1	-1.3	1.0	-1.2	-1.9
Blood Eosinophil Count	0.3	2.1	8.7	-0.1	3.0	-0.4	0.3	-2.1	-0.7	-0.9
Blood Platelet Count	1.2	14.1	32.4	-3.9	2.6	-4.5	-2.6	-5.7	-4.1	-0.9
Blood Red Count	1.0	9.4	37.1	3.1	6.1	1.9	1.8	-1.2	2.0	2.5
Blood White Count	0.4	3.2	13.8	1.0	3.7	-0.4	0.0	-2.5	-1.1	-0.0
Heel T-Score	0.2	1.8	3.4	1.1	-0.1	1.8	1.6	1.2	1.7	1.1
BMI	0.1	0.8	2.1	-1.4	0.2	-0.2	-1.0	1.4	-0.7	-0.4
Height	7.8	150.4	252.8	-14.2	-7.3	-13.7	-15.9	3.8	-12.7	-13.5
Waist Hip Ratio (WHR)	0.4	1.6	2.7	1.2	-1.5	1.6	1.1	1.6	0.6	1.2
Systolic Blood Pressure	0.6	3.0	11.5	1.0	3.4	0.1	0.8	-2.3	-0.6	1.6
Smoking Status	0.3	0.8	4.9	-0.3	-0.2	-0.8	0.2	-2.2	-0.2	-0.2
Allergy or Eczema	0.2	0.6	1.6	0.3	1.3	1.1	0.5	-0.9	0.4	0.3
Cardiovascular Disease	0.4	1.2	2.0	-0.1	1.0	-1.4	-1.0	-1.0	-1.4	1.1
Hypothyroidism (self reported)	1.9	4.3	19.1	1.4	2.6	-0.1	1.0	-4.4	-0.0	1.1
Respiratory disease	1.4	3.1	10.0	-0.6	0.3	-2.8	-0.4	-3.2	-1.8	-0.8
Type 2 Diabetes (T2D) (2018)	0.5	1.0	4.2	-0.3	0.0	-2.1	-0.6	-0.7	-0.4	-1.3
Lung FEV1/FVC ratio	2.3	11.9	38.7	2.1	0.4	6.2	3.1	2.3	4.4	2.3
Lung FVC	10.2	51.8	99.8	-8.8	-3.3	-7.5	-10.0	1.7	-7.6	-7.6
Neuroticism	0.7	1.6	2.9	-1.4	0.6	-1.5	-1.7	0.3	-1.7	-0.8
Chronotype (morning person)	0.3	0.8	2.7	0.9	0.3	-1.0	0.5	-0.6	0.6	1.6
Hair Pigment	0.0	0.5	1.6	1.3	-0.6	0.1	-0.1	0.5	1.1	-0.4
Tanning	0.1	1.0	2.5	-0.1	0.1	1.6	0.7	1.5	1.2	-0.7
Hand grip strength (left)	2.9	7.6	13.4	-2.4	-2.9	-2.7	-3.5	1.4	-2.0	-3.7
Number of treatments/medications taken	0.6	1.0	4.0	0.2	0.9	-1.2	-0.2	-2.0	-0.3	0.7
Average weekly spirits intake	2.5	3.1	5.0	-2.2	-1.6	-1.4	-1.7	0.2	-2.0	-2.2
Sensitivity / hurt feelings	0.7	1.1	4.0	-1.1	2.0	-0.9	-1.0	0.3	-0.9	-0.2
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.8	-0.9	0.7	0.2	-0.8	0.4	-0.4	-0.6
Hearing difficulty/problems: Yes	1.0	1.5	7.3	0.8	2.7	1.0	0.4	-0.5	0.7	0.7
Relative age of first facial hair	0.2	0.5	0.8	0.7	-0.9	0.4	0.9	-0.7	0.4	0.7
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.6	-0.4	0.1	-0.8	-0.5	-0.6	-0.5	0.4
Ever used hormone-replacement therapy (HRT)	1.1	1.4	3.0	1.7	0.2	0.4	1.3	-0.8	1.6	1.4
Ever had hysterectomy (womb removed)	0.1	0.2	0.5	0.3	0.4	-0.4	0.4	-0.1	0.2	0.7
Systolic blood pressure, automated reading	0.8	2.4	8.5	0.1	1.7	-1.4	0.3	-2.9	-1.8	0.7
Eye problems/disorders: Diabetes related eye disease	1.8	2.0	4.2	2.0	-0.7	0.4	1.9	-1.0	1.4	1.6
Angina	1.2	1.6	4.9	-0.6	-2.2	-0.7	-1.2	1.5	0.1	-1.2
Medication for hormone replacement therapy	0.9	1.0	3.7	0.3	-0.0	-1.0	0.6	-1.9	-0.1	1.5
Vitamin and mineral supplements	1.9	2.6	5.8	1.4	0.0	2.4	1.4	1.9	2.1	0.7
Supplements: Zinc	0.4	0.4	1.2	-1.1	0.2	0.5	-0.7	0.3	-0.3	-0.8
Medication: Co-codamol	1.8	2.1	3.9	2.0	1.6	0.9	1.4	-0.0	2.0	1.1
Medication: Metformin	0.7	1.0	2.6	-0.6	-1.1	-1.6	-0.9	-0.1	-0.4	-1.5
Diabetes (father)	1.6	1.9	4.3	2.1	-0.2	-0.1	2.0	-1.4	0.5	1.7
Diabetes (mother)	1.4	1.8	2.9	1.6	-1.7	0.7	1.5	0.9	0.9	1.6
Severe depression (siblings)	1.8	2.0	4.0	1.5	0.0	0.9	1.9	-0.1	1.8	2.0
Pack years adult smoking proportion	0.7	1.1	2.7	-0.4	-1.0	-1.3	-0.3	-1.6	-1.1	-0.8
Impedance of leg (right)	0.9	4.3	9.4	3.0	3.1	-0.3	1.2	-1.7	1.6	2.3
Leg fat-free mass (left)	5.1	26.8	45.4	-6.7	-4.0	-4.2	-6.2	3.0	-5.0	-5.9
Trunk fat percentage	1.1	4.3	12.2	-1.9	0.4	-3.5	-3.0	0.7	-1.8	-1.4
Hand grip strength (right)	2.7	7.2	11.5	-2.3	-2.6	-3.1	-3.4	0.8	-2.4	-3.4
Townsend deprivation index at recruitment	1.1	1.5	3.2	1.3	0.6	0.4	1.6	-0.7	1.5	1.8
Current tobacco smoking	0.7	1.2	6.8	0.0	0.2	-0.8	0.3	-2.6	-0.7	-0.2
Average weekly fortified wine intake	0.5	0.6	1.5	-0.4	-0.7	-1.2	-0.7	-0.3	-0.6	-1.0
Maternal smoking around birth	2.7	3.9	6.2	2.2	0.1	2.5	2.3	-0.3	2.3	2.4
Fed-up feelings	0.6	1.1	3.9	-1.0	0.6	0.1	-1.0	2.0	-0.4	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.2	0.1	-0.4	-0.2	0.3	-0.2	-0.4	0.0
Relative age voice broke	0.8	1.3	3.2	-0.5	-0.8	-1.6	-0.2	-1.8	-1.4	0.5
Taking other prescription medications	1.3	2.0	7.4	-0.1	2.7	-1.7	-0.5	-1.8	-0.3	0.2
Age when periods started (menarche)	0.5	1.1	3.1	1.8	0.2	0.6	1.1	-1.4	0.8	0.8
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.3	-0.2	-0.1	-1.2	-0.4	-1.1	-0.5	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.2	-0.1	0.5	0.1	0.1	1.1	0.9	0.9
Tinnitus: Yes, but not now, but have in the past	2.3	2.5	5.6	1.9	-0.8	1.3	2.4	-1.5	0.8	1.8
Qualifications: CSEs or equivalent	0.3	0.4	1.2	-0.6	0.1	-1.1	-0.8	0.1	-0.5	-0.1
Serious illness, injury or assault to yourself	2.7	3.3	5.5	2.3	0.6	1.7	2.2	-0.6	2.1	2.3
High blood pressure	0.8	2.3	5.1	0.4	2.1	-1.2	0.2	-2.2	-1.5	1.7
Hayfever, allergic rhinitis or eczema	0.7	1.5	5.3	0.4	2.3	1.9	0.3	-0.3	0.9	-0.2
Multivitamins +/- minerals	1.8	2.3	3.9	-1.8	-0.8	-1.9	-1.2	-1.6	-2.0	-1.0
Stomach or abdominal pain in last month	1.0	1.3	2.1	-1.2	1.3	0.7	-1.3	1.4	0.0	-1.2
Supplements: Glucosamine	0.4	0.6	1.5	-0.3	-1.2	-0.2	-0.3	0.7	-0.5	-1.2
Diverticular disease/diverticulitis (self-reported)	6.0	7.1	14.1	2.6	2.5	3.8	2.0	2.4	3.2	1.5
Medication: Atenolol	2.4	2.9	6.3	2.5	0.6	2.0	2.1	-0.2	1.6	1.7
Medication: Levothyroxine sodium	1.5	2.5	9.1	0.3	3.0	0.3	-0.1	-2.9	-0.4	0.0
Sitting height	5.4	38.6	78.5	-7.4	-2.5	-5.9	-8.9	3.8	-5.3	-7.3
Chronic bronchitis/emphysema (father)	0.7	0.8	4.2	0.5	0.2	-0.4	0.8	-2.0	-0.3	0.6
High blood pressure (mother)	0.8	1.1	5.9	-0.5	-0.6	1.0	-0.6	2.4	0.1	-0.0
Body mass index (BMI)	0.1	0.4	1.1	-1.0	-0.2	-0.5	-0.7	0.8	-0.5	-0.4
Impedance of leg (left)	1.1	5.1	13.7	3.1	3.7	-0.0	1.2	-1.4	1.8	2.5
Leg predicted mass (left)	5.1	26.9	45.7	-6.8	-4.0	-4.2	-6.2	3.0	-5.1	-5.9
Trunk fat mass	2.2	9.5	18.1	-3.4	-0.7	-4.2	-4.3	1.3	-3.1	-2.8
Waist circumference	1.1	4.1	7.0	-2.3	-1.3	-2.5	-2.6	1.6	-2.0	-1.6
Number of incorrect matches in round	0.2	0.3	0.9	-0.6	-0.4	-1.0	-0.6	0.1	-0.0	-0.4
Past tobacco smoking	1.8	3.4	5.4	2.2	0.9	2.3	1.8	0.6	2.1	2.2
Alcohol usually taken with meals	0.4	0.6	1.9	-0.7	-0.3	-0.5	-1.4	1.0	0.3	-0.7
Nervous feelings	2.3	4.3	8.1	-2.2	0.9	-2.6	-2.1	-1.1	-2.8	-2.0
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	3.4	-0.3	0.1	0.6	-0.3	1.9	-0.1	-0.7
Hearing difficulty/problems with background noise	0.4	0.7	1.7	-0.1	1.1	-0.4	-0.5	-1.3	-0.1	-1.1
Hair/balding pattern: Pattern 2	0.1	0.1	0.6	-0.8	0.0	-0.1	-0.0	-0.1	-0.2	0.0
Had menopause	0.9	1.1	3.1	0.7	-1.2	0.5	1.2	-1.8	-0.1	1.0
Had other major operations	0.8	1.0	3.1	0.1	-0.5	-1.8	0.2	-1.6	-0.9	0.2
Forced vital capacity (FVC)	13.4	51.6	98.6	-8.4	-3.3	-7.7	-9.9	3.0	-6.9	-8.1
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.5	-0.3	-0.2	0.1	0.1	1.2	0.7	0.8
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.4	-0.1	-0.7	0.0	0.4	0.4	-0.1	0.2
Qualifications: None of the above	1.1	2.4	3.5	1.6	1.8	1.9	1.6	-0.6	1.6	1.4
Financial difficulties in last 2 years	0.5	0.6	1.9	-0.1	1.1	-0.4	-0.2	-1.4	-1.1	-0.1
Mouth/teeth dental problems	0.3	0.5	1.1	-0.7	-0.3	0.2	-0.8	1.0	0.4	-1.0
Heart attack	0.6	0.8	3.7	1.9	0.6	-0.5	0.7	-0.3	0.7	0.2
Allergy	0.3	0.8	1.9	0.9	-1.4	-0.2	0.6	0.9	0.7	1.0
Pain all over the body in last month	1.5	1.6	2.8	1.4	1.2	1.7	1.5	0.5	1.2	1.2
Diabetes (self-reported)	0.4	0.6	1.4	0.8	-0.0	-1.2	0.6	-1.2	0.2	-0.7
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	3.1	0.8	1.6	0.9	1.0	-1.8	0.4	0.4
Medication: Ramipril	1.0	1.3	3.2	-0.3	0.2	-1.3	-0.6	-1.8	-1.5	-1.3
Medication: Simvastatin	0.4	0.6	1.1	-0.6	-0.7	-1.1	-1.0	-0.7	-0.5	-0.3
Fluid intelligence score	0.7	1.4	2.4	1.1	-1.6	0.9	1.1	0.5	1.5	1.3
Illnesses of siblings	0.9	1.3	3.2	-0.5	-1.6	0.8	-0.7	1.8	0.5	-1.2
Neuroticism score	0.6	1.3	2.0	-1.3	1.4	-0.9	-1.4	0.6	-1.1	-1.1
Weight	3.8	18.6	30.5	-5.3	-2.4	-4.6	-5.5	2.0	-4.4	-4.7
Impedance of arm (right)	0.3	1.4	6.2	0.8	1.2	-2.5	-0.8	-0.5	0.2	0.5
Arm fat percentage (right)	0.3	1.2	2.7	-1.1	0.4	-1.6	-1.6	0.8	-0.8	-0.7
Trunk fat-free mass	4.9	28.3	46.2	-6.8	-4.1	-4.3	-6.3	2.2	-5.8	-6.2
Hip circumference	3.4	14.4	26.5	-4.4	-1.0	-5.2	-5.1	1.1	-3.7	-3.8
Time employed in main current job	0.4	0.4	1.2	0.6	0.6	1.1	0.3	0.6	0.5	0.5
Alcohol intake versus 10 years previously	0.2	0.2	0.8	0.3	-0.2	-0.7	0.2	-0.2	0.9	-0.0
Father’s age at death	2.3	3.1	7.5	-1.7	-2.7	-1.3	-1.7	0.2	-2.1	-1.5
Worrier / anxious feelings	0.9	1.7	3.3	-1.3	1.4	-0.4	-1.8	0.9	-1.3	-1.6
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.3	-1.1	-0.9	-0.2	-0.8	0.8	-0.9	-1.0
Falls in the last year	0.5	0.6	1.8	-0.5	-0.6	-1.3	-0.3	-0.5	-1.2	-0.5
Hair/balding pattern: Pattern 3	0.1	0.2	0.9	-0.0	0.2	1.0	-0.1	0.2	-0.3	-0.5
Number of live births	0.3	0.4	1.3	0.2	-0.9	0.6	1.1	0.3	-0.2	0.5
Forced expiratory volume in 1-second (FEV1)	10.6	35.7	71.4	-7.4	-2.5	-5.0	-8.4	4.2	-5.3	-6.9
Pulse rate	0.1	0.2	0.6	0.5	-0.8	-0.1	0.4	0.1	-0.5	-0.7
Happiness	0.3	0.4	1.1	1.0	-0.2	0.8	0.7	0.3	0.7	0.1
Noisy workplace	0.4	0.6	1.2	0.5	1.1	0.7	0.8	0.1	0.7	0.8
Qualifications: A levels/AS levels or equivalent	0.5	1.1	3.1	-1.1	-0.1	-1.5	-1.7	0.2	-1.2	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.2	0.7	0.4	0.3	0.2	0.2	-0.9	0.2	0.1
Mouth/teeth dental problems: Dentures	0.5	0.8	1.9	1.0	-0.2	0.3	1.4	0.3	0.9	1.3
Asthma	1.9	3.8	10.1	-1.3	0.8	-2.8	-0.5	-3.2	-2.4	-0.2
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	2.1	-1.4	1.5	-1.2	-1.1	-1.0	-1.2	-1.1
Medication: Cholesterol lowering	1.2	1.9	3.3	-1.0	-0.5	-1.8	-1.5	-1.2	-1.8	-1.3
Depression (self-reported)	0.3	0.4	1.5	-0.4	1.2	0.7	0.3	-0.0	0.6	-0.1
Medication: Lansoprazole	4.1	4.7	8.1	2.5	1.6	1.0	2.8	-1.3	2.5	2.6
Prospective memory result	0.8	1.0	1.8	-0.9	-0.4	-1.3	-1.1	-1.1	-0.3	-1.3
Lung cancer (father)	0.5	0.6	1.9	-0.7	-0.6	-0.4	0.4	-1.4	-0.9	0.3
Illnesses of mother	0.1	0.2	0.6	-0.5	0.8	0.2	0.0	-0.5	0.1	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	10.8	34.5	70.4	-7.3	-2.0	-4.8	-8.4	3.9	-5.4	-6.9
Pulse wave Arterial Stiffness index	1.0	1.1	3.8	-0.4	0.3	-0.9	-0.9	-2.0	-1.3	-0.7
Impedance of arm (left)	0.3	1.5	7.5	0.6	1.1	-2.7	-1.2	-0.3	-0.0	0.3
Arm fat mass (right)	1.2	4.9	9.1	-2.8	-0.7	-2.3	-3.0	1.5	-2.1	-2.1
Trunk predicted mass	4.9	27.9	45.4	-6.7	-4.1	-4.3	-6.2	2.2	-5.7	-6.2
Standing height	7.0	69.8	118.8	-9.6	-5.0	-8.9	-10.9	2.9	-8.6	-9.6
Length of working week for main job	0.4	0.5	1.3	-0.7	-1.1	0.4	-0.2	0.8	-0.6	-0.5
Exposure to tobacco smoke at home	0.8	0.9	2.0	1.0	0.5	1.1	1.4	-0.6	1.1	0.7
Breastfed as a baby	2.7	3.4	6.5	-1.8	-1.2	-2.2	-1.9	-0.4	-1.9	-2.5
Tense / ‘highly strung’	1.0	1.7	2.8	-1.5	1.4	-0.3	-1.5	-0.7	-1.7	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	4.1	-2.0	-0.6	-0.8	-1.7	0.6	-1.3	-0.5
Hair/balding pattern: Pattern 4	0.7	1.8	3.5	1.9	1.1	1.1	1.5	-0.2	1.5	1.3
Birth weight of first child	0.9	1.6	3.4	-1.4	-0.9	-1.0	-1.8	1.1	-0.6	-1.5
Peak expiratory flow (PEF)	7.4	17.2	30.1	-5.1	-2.1	-3.8	-5.5	3.1	-3.9	-4.5
Pulse wave reflection index	1.3	1.6	3.2	1.0	1.1	0.8	1.3	-1.7	0.7	1.8
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.7	0.0	0.4	0.8	0.0	0.8	0.0	-0.4
Loud music exposure frequency	0.1	0.1	0.4	-0.1	0.6	0.0	-0.0	0.1	0.1	0.4
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.0	1.0	0.5	0.6	0.7	0.0	1.0	0.8
Mouth/teeth dental problems: Bleeding gums	3.1	4.1	7.8	-1.9	-0.0	-2.2	-2.5	-1.4	-2.8	-2.0
Blood clot in the leg (DVT)	1.2	1.5	2.9	-1.7	-1.1	-1.2	-1.7	0.8	-0.6	-1.2
Medication: Paracetamol	0.8	1.4	4.0	-1.3	0.8	-2.0	-1.5	-0.1	-0.8	-0.5
Headache pain in last month	2.9	5.0	10.2	-3.2	0.3	-2.3	-2.5	-1.2	-2.8	-2.0
Medication for cholesterol, blood pressure or diabetes	1.5	2.4	5.7	1.2	0.3	2.0	1.2	1.9	2.4	0.6
Glaucoma (self-reported)	0.6	0.7	1.5	-0.1	-0.5	1.2	-0.5	1.2	0.5	-1.1
Gout (self-reported)	0.3	0.4	0.8	-0.7	-0.2	-0.9	0.2	-0.9	-0.3	0.5
Hypothyroidism/myxoedema (self-reported)	1.6	3.1	13.6	1.1	2.5	-0.2	0.7	-3.7	-0.0	0.5
Medication: Amlodipine	0.2	0.3	0.5	-0.4	0.7	-0.4	-0.3	0.1	-0.7	0.6
Medication: Ventolin 100micrograms inhaler	3.4	4.3	11.1	-1.5	-0.7	-3.3	-1.2	-3.0	-2.0	-1.5
Birth weight	1.8	3.8	8.2	-2.3	-1.2	0.1	-1.9	2.8	-0.8	-2.9
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.7	-0.7	0.5	-0.8	-0.7	-0.7	-0.6	0.0
High blood pressure (siblings)	0.5	0.7	2.8	-0.2	0.8	-0.4	-0.1	-1.7	-1.2	0.3
Forced vital capacity (FVC), Best measure	14.0	51.4	100.0	-8.4	-2.7	-7.3	-10.0	3.1	-7.2	-8.1
Body fat percentage	0.6	2.4	7.6	-1.2	0.8	-2.8	-2.2	0.6	-1.3	-0.9
Leg fat percentage (right)	0.2	0.8	4.0	0.6	2.0	-0.7	-0.1	-0.2	0.2	0.8
Arm fat-free mass (right)	4.5	22.8	39.4	-6.3	-3.5	-3.6	-5.8	2.4	-5.1	-5.4
Exposure to tobacco smoke outside home	0.7	1.0	1.7	1.2	0.2	0.9	1.2	-0.1	1.2	1.3
Comparative body size at age 10	1.1	2.9	7.1	0.3	1.0	2.7	0.8	2.6	1.9	1.1
Number of full brothers	0.4	0.5	2.4	-0.3	-0.4	-0.8	0.1	-1.6	-0.2	-0.6
Worry too long after embarrassment	0.4	0.7	2.7	-0.1	1.1	0.6	-0.2	1.6	0.1	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.8	-0.8	-0.9	-0.6	-0.4	-0.3	-0.5	-0.2
Wheeze or whistling in the chest in last year	2.0	3.5	12.1	-1.4	0.1	-2.4	-0.2	-3.5	-2.2	-0.1
Number of children fathered	0.2	0.2	1.0	-0.2	-1.0	0.3	0.5	-0.3	-0.6	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	3.0	3.5	6.7	-1.9	-1.8	-2.6	-1.9	-1.1	-2.4	-0.7
Age at first live birth	0.9	1.6	3.5	-1.6	-0.2	-1.2	-1.9	1.0	-1.1	-1.3
Pulse wave peak to peak time	0.6	0.7	4.0	-0.2	-0.4	0.4	0.2	2.0	0.8	0.2
Health satisfaction	0.2	0.3	1.1	0.1	-0.7	-0.3	-0.2	-0.3	-0.5	-1.1
Shortness of breath walking on level ground	0.4	0.4	1.3	0.6	-0.8	0.4	0.6	-1.1	0.1	0.3
Qualifications: College or University degree	0.1	0.4	1.2	-0.4	-1.1	-0.2	-0.7	0.7	-0.0	-0.2
Eye problems/disorders: None of the above	0.4	0.5	3.0	0.1	1.7	0.1	0.1	-0.7	-0.1	0.1
Mouth/teeth dental problems: Loose teeth	1.2	1.4	6.5	0.9	1.1	-0.4	0.7	-2.5	-0.6	0.6
Emphysema/chronic bronchitis	0.3	0.4	1.6	0.3	-1.3	0.4	0.4	0.4	0.4	-0.4
Medication for pain relief, constipation, heartburn	1.0	1.6	4.0	1.3	-0.9	2.0	1.5	0.3	0.9	1.3
Neck or shoulder pain in last month	0.2	0.3	0.7	-0.9	-0.9	0.2	-0.3	-0.1	-0.2	-0.3
Medication: Blood pressure	1.0	1.8	4.2	-0.9	1.0	-1.7	-1.0	-1.7	-2.1	0.0
Angina (self-reported)	1.1	1.4	4.4	-0.5	-2.1	-0.6	-1.1	1.3	-0.0	-1.3
Migraine (self-reported)	1.9	2.4	4.8	-1.9	-0.1	-1.1	-1.5	1.6	-1.5	-2.2
Medication: Ibuprofen	1.0	1.2	2.2	-1.1	0.4	-1.5	-0.9	-1.3	-1.4	-0.8
Medication: Allopurinol	0.1	0.1	0.3	-0.2	-0.2	-0.6	0.5	0.0	0.2	0.6
Medication: Omeprazole	0.4	0.4	0.8	0.5	0.5	0.2	0.6	0.9	0.9	0.7
Medication: Seretide 50 evohaler	0.6	0.7	2.5	-1.6	0.3	-0.4	-1.0	0.4	-0.7	-0.8
Mean time to correctly identify matches	0.9	1.7	3.2	1.8	0.3	1.3	1.7	-0.2	1.3	1.4
Heart disease (mother)	0.3	0.4	1.5	0.6	-0.4	0.8	0.1	1.2	0.2	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.8	0.7	-1.3	1.4	1.0	0.4	0.8	0.1
Whole body fat mass	1.8	7.7	14.7	-3.1	-0.6	-3.6	-3.8	1.4	-2.7	-2.6
Leg fat mass (right)	0.7	2.9	5.4	-2.0	0.1	-2.1	-2.3	1.0	-1.7	-1.5
Arm predicted mass (right)	4.6	23.4	39.3	-6.3	-3.5	-3.8	-5.9	2.4	-5.2	-5.5
Pulse rate, automated reading	0.8	2.5	7.0	1.2	-1.3	2.1	1.0	2.6	1.0	1.0
Alcohol intake frequency.	0.3	0.8	2.0	1.4	0.2	0.7	0.6	0.3	1.2	1.0
Comparative height size at age 10	6.4	35.2	61.3	-6.9	-1.7	-6.5	-7.8	1.9	-6.6	-6.7
Number of full sisters	0.2	0.3	0.9	0.7	-0.3	-0.2	0.7	-1.0	0.1	0.0
Suffer from ‘nerves’	1.2	1.8	4.2	-2.0	-0.0	-2.0	-1.4	-0.6	-1.2	-0.8
Overall health rating	0.1	0.2	0.4	0.0	0.4	-0.6	-0.0	-0.3	-0.4	-0.6
Chest pain or discomfort	1.0	1.5	2.9	-0.6	-1.0	-1.6	-0.6	-1.7	-0.6	-1.7
Had major operations	0.9	1.0	6.1	-0.7	-2.5	-0.5	0.0	-0.4	-0.4	0.4
Age at last live birth	1.2	1.7	3.1	-1.8	-0.8	-0.6	-1.7	0.8	-1.2	-1.6
Family relationship satisfaction	0.2	0.3	0.7	0.5	-0.9	-0.1	0.4	0.3	0.8	-0.1
Leg pain on walking	0.5	0.6	2.3	-0.9	-0.1	0.5	-0.6	0.5	-0.7	-1.5
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.9	-0.3	0.7	-0.7	-0.7	1.0	-0.1	-0.5
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.6	-1.1	0.1	-0.3	-0.6	1.3	-0.2	-0.5
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.8	-0.5	-1.3	-0.8	-0.0	-0.4	0.2	-0.3
Medication: Aspirin	0.5	0.7	2.4	0.8	-0.1	-0.9	0.7	-1.5	-0.0	0.7
Supplements: Vitamin C	0.9	1.1	3.0	-0.9	0.4	-1.7	-1.2	-0.9	-1.1	-0.6
Knee pain experienced in last month	0.8	1.2	2.7	-1.6	-0.5	-0.8	-1.4	-0.4	-1.1	-1.3
Hypertension (Self-reported)	0.7	1.9	3.9	0.5	1.9	-1.3	0.0	-2.0	-1.4	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.4	0.2	1.2	0.8	0.2	0.9	0.4	-0.3
Illnesses of father: Heart disease	0.6	0.8	2.6	0.3	-1.3	0.2	-0.3	1.6	1.0	0.1
Illnesses of siblings: Diabetes	1.7	2.1	5.4	1.6	-0.6	0.6	2.2	-0.5	0.7	2.3
Smoking status: Previous	0.2	0.3	0.6	-0.7	-0.3	-0.6	-0.4	-0.3	-0.6	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	6.9	14.4	25.5	-4.3	-2.2	-3.5	-5.0	2.6	-2.9	-5.0
Whole body fat-free mass	5.0	28.4	47.1	-6.9	-4.2	-4.3	-6.3	2.6	-5.5	-6.2
Leg fat-free mass (right)	4.9	26.3	45.2	-6.7	-4.0	-4.0	-6.2	3.2	-4.8	-5.9
Arm fat percentage (left)	0.3	1.3	3.2	-1.1	0.4	-1.8	-1.7	0.7	-1.0	-0.6
Average weekly red wine intake	0.9	1.3	2.9	-1.3	-1.0	-0.8	-1.7	0.8	-0.7	-1.3
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.5	-0.5	-0.3	-0.3	-0.7	0.7	-0.5	-0.3
Mood swings	0.9	1.6	3.2	-1.8	0.9	-0.5	-1.3	1.0	-1.6	-1.3
Loneliness, isolation	0.4	0.5	2.0	-0.2	1.4	-1.0	-0.5	0.4	-0.2	-0.1
Long-standing illness, disability or infirmity	0.5	0.8	1.5	0.7	-1.0	-0.7	1.0	-1.2	-0.1	0.9
Ever had bowel cancer screening	0.4	0.5	2.0	-0.9	-0.1	-0.6	-1.4	0.2	-0.4	-0.6
Diabetes diagnosed by doctor	0.5	0.9	2.6	1.1	0.2	-1.0	1.0	-1.6	0.5	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	2.0	-0.3	1.4	-0.2	0.4	-0.8	-0.5	0.5
Friendships satisfaction	0.3	0.4	1.0	1.0	-1.0	0.5	0.7	-0.0	0.3	-0.3
Qualifications: nursing, teaching	0.2	0.3	1.1	-0.2	-1.1	-0.0	-0.4	0.8	0.3	-0.7
Commuting to job workplace: Walk	0.5	0.5	1.5	0.1	1.1	-0.1	-0.2	-1.2	-0.6	0.5
Eye problems/disorders: Cataract	0.2	0.3	0.8	0.1	-0.9	-0.2	-0.0	-0.6	-0.5	0.7
Mouth/teeth dental problems: Mouth ulcers	0.9	1.5	2.7	1.5	0.1	1.2	1.5	0.1	1.4	1.7
Medication for cholesterol	0.7	1.0	2.3	-1.5	0.0	0.5	-0.7	1.2	-0.8	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	2.2	-0.4	0.4	1.5	0.1	0.6	0.5	0.4
Back pain experienced in last month	2.6	3.8	8.1	-2.5	-0.7	-2.8	-1.9	-1.3	-2.2	-1.4
Mineral and other dietary supplements	0.7	1.0	2.1	0.5	0.7	1.5	0.9	1.0	0.6	1.3
Breast cancer (self-reported)	0.8	1.0	3.3	0.4	0.2	-1.2	0.6	-1.8	-0.6	1.1
Asthma (self-reported)	2.1	4.1	10.4	-1.4	1.4	-2.9	-0.6	-3.2	-2.4	-0.2
Osteoporosis (self-reported)	0.4	0.5	0.8	0.7	-0.9	-0.9	0.6	-0.9	0.3	0.6
Osteoarthritis (self-reported)	1.4	1.8	2.9	-1.6	-0.7	-1.3	-1.5	-1.1	-1.7	-1.2
Medication: Aspirin	0.4	0.5	2.0	0.6	-0.1	-0.9	0.3	-1.4	-0.4	0.4
Medication: Gliclazide	1.2	1.3	4.4	-0.4	-1.1	-2.1	0.1	-1.7	-0.9	-0.3
Illnesses of father: None of the above (group 1)	0.8	1.0	2.4	-0.9	0.1	-1.3	-0.7	-1.4	-1.6	-0.3
Smoking status: Current	0.7	1.1	5.3	-0.2	0.3	-1.1	-0.0	-2.3	-0.7	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.1	8.7	19.3	-4.2	-0.4	-1.8	-4.4	1.6	-3.0	-3.0
Whole body water mass	5.0	28.7	48.0	-6.9	-4.1	-4.4	-6.4	2.5	-5.6	-6.2
Leg predicted mass (right)	5.0	26.7	46.2	-6.8	-4.0	-4.1	-6.2	3.1	-5.0	-5.9
Arm fat mass (left)	1.3	5.4	10.0	-2.9	-0.6	-2.7	-3.2	1.2	-2.4	-2.1
Number of self-reported non-cancer illnesses	1.3	2.2	10.2	0.8	0.4	-1.3	1.0	-3.2	-0.7	1.2
Average weekly champagne plus white wine intake	1.4	1.9	4.8	-1.0	0.6	-0.2	-1.6	2.0	-0.5	-2.2
Miserableness	0.4	0.6	1.4	-1.0	0.6	0.2	-1.0	0.1	-0.9	-1.2
Guilty feelings	0.7	1.0	3.6	0.4	0.5	1.0	0.5	1.9	1.2	0.7
Wears glasses or contact lenses	1.0	1.1	2.0	-0.9	1.2	-1.3	-1.4	-0.2	-1.3	-0.6
Ever taken oral contraceptive pill	1.2	1.4	2.5	-1.2	0.3	-1.6	-1.3	-0.6	-1.5	-1.1
Hearing aid user	0.5	0.6	2.0	0.4	1.0	0.7	-0.1	1.4	-0.1	0.6
Mother’s age at death	0.4	0.5	1.0	-0.6	0.5	-0.4	-1.0	1.0	-0.6	-0.7
Financial situation satisfaction	0.6	0.7	1.2	1.1	0.9	0.9	0.8	-0.5	0.7	0.9
Tinnitus: Yes, now most or all of the time	0.8	0.9	3.2	0.0	0.4	0.0	-1.0	1.8	1.1	-0.9
Commuting to job workplace: Public transport	0.2	0.2	0.6	-0.1	-0.2	0.5	-0.8	0.5	-0.3	-0.3
Eye problems/disorders: Glaucoma	0.7	0.8	1.8	-1.2	-0.7	-0.5	-1.4	0.5	-0.8	-0.9
Medication: Blood pressure	1.0	1.8	5.7	2.4	-0.1	0.8	1.7	-0.2	1.3	1.4
Pain type(s) experienced in last month: Hip pain	1.2	1.5	3.1	-1.4	0.3	-1.4	-1.2	-0.4	-1.8	-1.4
Supplements: Fish oil (including cod liver oil)	1.1	1.4	3.8	-0.8	-0.4	-1.9	-1.0	-1.3	-1.0	-1.1
High cholesterol (Self-reported)	1.2	2.1	4.6	-1.2	-0.7	-1.7	-2.1	-0.6	-1.7	-1.3
Medication: Bendroflumethiazide	0.9	1.4	3.6	0.8	1.8	-1.0	0.6	-1.9	-0.4	0.8
Medication: Paracetamol	0.9	1.4	3.0	-1.3	0.2	-1.7	-1.7	-0.1	-1.3	-0.9
Medication: Lisinopril	0.5	0.6	1.6	1.3	-0.5	0.7	0.9	0.9	0.6	0.2
Medication: Atorvastatin	1.7	2.0	5.1	-1.2	-0.2	-2.3	-1.9	0.4	-1.0	-1.8
Illnesses of father: High blood pressure	3.3	4.1	12.3	1.7	1.1	3.5	1.9	1.4	1.8	1.9
Alcohol drinker status: Never	0.6	0.7	1.5	0.8	0.1	1.2	1.1	-0.0	1.2	0.5
Ever smoked	3.1	5.4	8.9	-2.6	-1.0	-3.0	-2.1	-1.3	-2.8	-2.7
Basal metabolic rate	4.9	27.3	45.4	-6.7	-3.7	-4.5	-6.4	2.6	-5.4	-6.0
Leg fat percentage (left)	0.3	1.0	5.0	0.6	2.2	-0.8	-0.1	-0.2	0.3	0.8
Arm fat-free mass (left)	4.2	21.1	36.0	-6.0	-3.3	-3.7	-5.5	2.2	-5.0	-5.3
Number of operations (self-reported)	0.7	1.1	2.5	-0.3	-0.6	-1.5	0.1	-1.6	-0.5	1.4
Average weekly beer plus cider intake	1.4	2.0	4.8	-1.8	-2.2	-1.2	-1.0	1.3	-1.3	-0.6
Irritability	1.2	2.0	3.9	-1.4	0.1	-2.0	-1.9	1.1	-1.2	-1.3
Risk taking	0.6	0.8	2.1	0.7	-0.9	1.4	1.3	0.7	0.3	0.4
Ever had prostate specific antigen (PSA) test	2.1	2.5	4.2	-2.0	1.2	-1.2	-2.0	0.5	-1.3	-2.0
Fractured/broken bones in last 5 years	0.5	0.6	2.0	-0.6	-0.4	-1.4	-0.5	-0.7	-0.9	-0.5
Age started oral contraceptive pill	0.9	1.1	3.5	0.1	-1.9	-1.0	-0.0	-1.6	-0.8	0.1
Diastolic blood pressure, automated reading	1.0	3.2	6.8	2.0	1.9	0.5	2.2	-1.6	0.4	2.6
Ever depressed for a whole week	0.7	0.9	1.8	0.9	-1.3	0.8	1.3	-0.8	0.5	0.8
Unable to work because of sickness or disability	1.5	1.9	5.2	1.3	0.9	0.0	1.6	-1.7	0.7	2.3
Commuting to job workplace: Cycle	0.3	0.4	1.6	-0.0	-0.8	0.5	0.4	1.3	0.4	-0.1
Myopia	0.5	0.7	1.6	-0.3	-0.7	-0.6	-0.7	1.3	0.8	-1.0
Vascular/heart problems diagnosed by doctor	0.8	2.2	6.2	-0.1	-0.9	1.7	0.0	2.5	1.8	-1.4
Cholesterol lowering medication	0.3	0.4	1.5	0.0	-0.6	-1.2	-0.6	-0.8	-0.0	0.2
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	2.4	0.1	0.3	0.2	0.3	1.6	0.8	0.1
Pain experienced in last month	3.4	5.7	11.7	3.4	0.1	2.7	2.5	1.1	3.0	2.0
Supplements: Calcium	0.9	1.0	2.3	-0.6	0.2	-1.3	-1.5	0.4	-1.0	-1.4
Basal cell carcinoma (self-reported)	2.1	2.4	5.2	-2.1	-0.1	-0.7	-2.3	0.9	-1.6	-1.9
Heart attack/myocardial infarction (self-reported)	0.7	0.9	4.3	2.1	0.6	-0.6	0.7	-0.3	0.7	0.1
Deep venous thrombosis (DVT) (self-reported)	1.2	1.6	3.1	-1.8	-1.1	-1.1	-1.7	1.0	-0.6	-1.3
Heart disease (siblings)	1.1	1.3	3.8	0.4	1.9	-1.2	0.2	-1.8	-0.0	0.7
Alcohol drinker status: Previous	0.7	0.8	3.0	0.2	-1.6	0.5	-0.1	1.7	0.4	0.2
Pack years of smoking	0.9	1.3	3.0	-0.5	-1.2	-1.5	-0.3	-1.7	-1.2	-0.9
Impedance of whole body	0.4	2.1	4.8	2.0	2.2	-1.6	0.0	-0.8	1.0	1.4
Leg fat mass (left)	0.7	2.9	5.7	-2.0	0.2	-2.1	-2.4	1.2	-1.6	-1.4
Arm predicted mass (left)	4.0	20.3	35.0	-5.9	-3.1	-3.8	-5.4	2.0	-4.9	-5.1