[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1) : ← →

chr6:129,638,583-131,163,098

Best TWAS P=1.01e-17 · Best GWAS P=1.73e-24 conditioned to 7.73e-15

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	L3MBTL3	0.20	0.08	lasso	4	0.09	1.1e-07	8.2	7.5	7.0e-14	-0.32	1.00	0.00	FALSE
2	GTEx	Adipose Visceral Omentum	L3MBTL3	0.14	0.12	lasso	2	0.15	2.8e-08	8.2	7.8	9.5e-15	-0.32	0.95	0.00	FALSE
3	GTEx	Breast Mammary Tissue	L3MBTL3	0.31	0.25	lasso	7	0.23	2.8e-12	8.2	7.8	4.2e-15	-0.29	1.00	0.00	FALSE
4	GTEx	Breast Mammary Tissue	RP11-73O6.3	0.27	0.22	lasso	9	0.22	1.5e-11	8.2	7.9	2.3e-15	-0.29	1.00	0.00	FALSE
5	GTEx	Breast Mammary Tissue (Male)	L3MBTL3	0.31	0.24	lasso	6	0.23	5.5e-06	8.2	7.5	8.4e-14	-0.33	0.27	0.05	FALSE
6	GTEx	Breast Mammary Tissue (Male)	RP11-73O6.3	0.33	0.17	lasso	4	0.12	1.3e-03	8.2	7.6	2.4e-14	-0.30	0.16	0.05	FALSE
7	GTEx	Breast Mammary Tissue (Female)	L3MBTL3	0.30	0.13	lasso	5	0.14	4.5e-05	6.2	7.6	2.4e-14	-0.28	0.36	0.12	FALSE
8	GTEx	Breast Mammary Tissue (Female)	RP11-73O6.3	0.29	0.08	lasso	5	0.10	5.7e-04	6.5	7.5	4.5e-14	-0.32	0.29	0.11	FALSE
9	GTEx	Cells EBV-transformed lymphocytes	L3MBTL3	0.28	0.08	lasso	10	0.03	4.4e-02	8.2	7.4	1.1e-13	-0.36	0.21	0.10	FALSE
10	GTEx	Colon Transverse	L3MBTL3	0.27	0.13	lasso	8	0.20	8.0e-10	8.2	7.5	8.2e-14	-0.35	1.00	0.00	FALSE
11	GTEx	Colon Transverse	RP11-73O6.3	0.19	0.09	lasso	2	0.06	1.2e-03	8.2	8.1	5.1e-16	-0.33	0.52	0.02	FALSE
12	GTEx	Esophagus Mucosa	L3MBTL3	0.26	0.18	lasso	2	0.23	2.7e-15	6.5	7.9	2.0e-15	-0.32	1.00	0.00	FALSE
13	GTEx	Lung	L3MBTL3	0.37	0.34	lasso	4	0.38	4.1e-30	8.2	8.0	1.9e-15	-0.32	1.00	0.00	FALSE
14	GTEx	Lung	RP11-73O6.3	0.15	0.08	lasso	5	0.12	2.2e-09	8.2	7.7	1.8e-14	-0.32	1.00	0.00	FALSE
15	GTEx	Nerve Tibial	L3MBTL3	0.30	0.23	lasso	4	0.22	2.3e-15	8.2	8.2	2.6e-16	-0.31	1.00	0.00	FALSE
16	GTEx	Pancreas	L3MBTL3	0.32	0.17	lasso	4	0.23	4.4e-10	8.2	8.1	7.8e-16	-0.32	1.00	0.00	FALSE
17	GTEx	Pituitary	L3MBTL3	0.45	0.31	lasso	8	0.29	5.1e-08	6.2	6.7	2.0e-11	-0.15	0.87	0.01	FALSE
18	GTEx	Pituitary	RP11-73O6.3	0.48	0.07	lasso	7	0.16	8.2e-05	6.2	6.4	2.1e-10	-0.09	0.42	0.03	FALSE
19	GTEx	Prostate	L3MBTL3	0.35	0.27	lasso	5	0.17	5.9e-05	8.2	7.9	2.6e-15	-0.30	0.27	0.04	FALSE
20	GTEx	Skin Not Sun Exposed Suprapubic	L3MBTL3	0.26	0.12	lasso	4	0.12	4.0e-07	5.9	7.5	5.4e-14	-0.34	0.90	0.06	FALSE
21	GTEx	Skin Sun Exposed Lower leg	L3MBTL3	0.25	0.25	lasso	9	0.24	1.4e-19	8.2	7.6	2.3e-14	-0.27	1.00	0.00	FALSE
22	GTEx	Small Intestine Terminal Ileum	L3MBTL3	0.37	0.20	lasso	4	0.17	1.3e-04	8.2	8.3	1.0e-16	-0.35	0.18	0.06	FALSE
23	GTEx	Spleen	L3MBTL3	0.64	0.34	enet	14	0.48	6.4e-14	6.5	7.3	2.8e-13	-0.33	0.98	0.00	FALSE
24	GTEx	Spleen	RP11-73O6.3	0.45	0.43	enet	21	0.42	7.7e-12	6.5	7.4	1.2e-13	-0.29	0.98	0.00	FALSE
25	GTEx	Stomach	L3MBTL3	0.36	0.18	enet	27	0.20	1.1e-09	5.8	6.8	7.6e-12	-0.40	1.00	0.00	FALSE
26	GTEx	Testis	L3MBTL3	0.41	0.22	lasso	8	0.30	9.2e-14	8.2	8.5	1.4e-17	-0.35	0.97	0.02	FALSE
27	GTEx	Thyroid	L3MBTL3	0.40	0.39	enet	9	0.43	2.8e-35	8.2	8.0	1.5e-15	-0.36	1.00	0.00	FALSE
28	GTEx	Thyroid	RP11-73O6.3	0.18	0.15	lasso	3	0.20	2.3e-15	5.7	7.5	5.3e-14	-0.32	1.00	0.00	FALSE
29	GTEx	Whole Blood	L3MBTL3	0.22	0.20	lasso	9	0.20	5.1e-18	8.2	8.1	4.5e-16	-0.33	1.00	0.00	FALSE
30	GTEx	Whole Blood	RP11-73O6.3	0.15	0.06	lasso	8	0.04	1.1e-04	8.2	8.6	1.0e-17	-0.34	0.43	0.12	TRUE
31	METSIM	Adipose	L3MBTL3	0.13	0.12	enet	22	0.12	4.8e-18	6.5	6.5	8.0e-11	-0.20	1.00	0.00	FALSE
32	ROSMAP	Brain Pre-frontal Cortex	L3MBTL3	0.14	0.07	blup	609	0.08	3.8e-10	8.2	6.7	2.3e-11	-0.37	1.00	0.00	FALSE
33	YFS	Blood	L3MBTL3	0.28	0.22	blup	614	0.27	1.2e-88	6.5	5.4	5.6e-08	-0.22	1.00	0.00	FALSE