Best TWAS P=1.61e-08 · Best GWAS P=3.28e-10 conditioned to 0.0168
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | ERCC6L2 | 0.22 | 0.18 | enet | 39 | 0.18 | 5.2e-14 | 4.7 | 5.2 | 2.1e-07 | -0.05 | 0.91 | 0.09 | FALSE |
| 2 | GTEx | Breast Mammary Tissue | ERCC6L2 | 0.17 | 0.02 | lasso | 4 | 0.03 | 1.2e-02 | 4.7 | 5.4 | 8.8e-08 | -0.03 | 0.27 | 0.05 | FALSE |
| 3 | GTEx | Esophagus Muscularis | ERCC6L2 | 0.15 | 0.10 | lasso | 6 | 0.08 | 8.8e-06 | 4.8 | 5.4 | 7.1e-08 | -0.01 | 0.80 | 0.09 | TRUE |
| 4 | GTEx | Liver | PTCH1 | 0.25 | 0.06 | enet | 11 | 0.03 | 4.9e-02 | 6.1 | 5.6 | 1.6e-08 | 0.91 | 0.01 | 0.92 | TRUE |
| 5 | GTEx | Nerve Tibial | HSD17B3 | 0.14 | 0.00 | enet | 20 | 0.00 | 2.4e-01 | 4.4 | 5.1 | 2.8e-07 | 0.04 | 0.04 | 0.63 | TRUE |