TWAS hub - HSD17B3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.2080	0.0570	2.5e-06	0.007	NA	0.043	NA	0.030	8.1e-02	NA	1.9e-04	NA	1.7e-03
2	GTEx	Cells Transformed fibroblasts	0.0830	0.0340	8.0e-03	0.054	NA	0.048	NA	0.046	6.7e-05	NA	1.6e-04	NA	2.4e-04
3	GTEx	Nerve Tibial	0.1392	0.0512	1.3e-03	-0.003	NA	0.001	NA	-0.001	6.8e-01	NA	2.4e-01	NA	3.9e-01
4	GTEx	Pancreas	0.2430	0.0750	4.2e-04	0.116	NA	0.078	NA	0.093	1.3e-05	NA	3.4e-04	NA	9.4e-05
5	GTEx	Testis	0.2010	0.0770	9.1e-03	0.177	NA	0.117	NA	0.157	2.8e-08	NA	7.2e-06	NA	1.9e-07
6	METSIM	Adipose	0.0595	0.0251	2.0e-03	-0.001	0.012	0.004	0.015	-0.002	4.5e-01	0.00510	7.3e-02	0.0024	7.7e-01
7	TCGA	Breast Invasive Carcinoma	0.0218	0.0103	1.6e-03	0.010	0.007	0.008	NA	0.007	2.7e-03	0.00920	7.3e-03	NA	9.9e-03
8	TCGA	Colon Adenocarcinoma	0.0730	0.0360	4.4e-03	0.064	0.041	0.006	NA	0.038	1.5e-04	0.00190	1.3e-01	NA	2.9e-03
9	TCGA	Kidney Renal Clear Cell Carcinoma	0.0327	0.0174	9.5e-03	0.002	0.011	0.001	NA	0.002	1.6e-01	0.01700	2.1e-01	NA	1.7e-01
10	TCGA	Lung Adenocarcinoma	0.0509	0.0219	7.0e-04	0.044	0.027	0.033	NA	0.032	6.7e-06	0.00035	9.0e-05	NA	1.0e-04
11	TCGA	Pancreatic Adenocarcinoma	0.1270	0.0670	7.4e-03	0.016	0.039	0.017	NA	0.016	6.9e-02	0.00910	6.5e-02	NA	6.9e-02
12	TCGA	Thyroid Carcinoma	0.0450	0.0200	1.2e-03	0.038	0.015	0.023	NA	0.026	1.2e-04	0.01100	2.5e-03	NA	1.3e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Standing height	4.3	42.4	146.4	10.7	4.4	12.1	4.5	-1.6	2.2	7.7	5.3	7.7	2.4	5.3	4.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	4.3	5.1	10.2	-1.3	-3.2	-0.3	-2.9	0.8	-1.9	-2.9	-2.1	-1.8	-3.0	-1.7	-3.0
Height	4.1	79.1	327.6	15.4	4.5	18.1	5.0	-1.8	4.0	9.9	6.5	10.0	1.4	7.2	5.1
Qualifications: NVQ or HND or HNC or equivalent	4.1	5.0	8.1	-1.9	-1.8	-1.6	-2.5	-1.9	-2.8	-2.7	-2.4	-2.1	-2.2	-1.9	-2.5
Sitting height	3.9	28.0	102.0	8.3	3.9	10.1	3.5	-1.7	2.0	6.2	4.4	6.2	1.6	4.5	3.5
Ever had prostate specific antigen (PSA) test	3.9	4.5	7.1	2.4	2.3	2.7	2.3	0.2	1.4	2.6	1.1	2.2	2.3	2.2	2.4
Diverticular disease/diverticulitis (self-reported)	3.8	4.5	9.5	0.9	1.6	0.1	2.6	3.1	2.3	2.2	1.0	0.8	2.8	3.1	2.3
Irritable Bowel Disease (IBD)	3.7	8.7	14.1	2.2	2.9	1.1	3.8	-0.2	1.7	3.7	3.1	3.4	3.7	3.4	3.8
Qualifications: CSEs or equivalent	3.4	4.5	7.3	-2.4	-1.8	-1.7	-2.4	-0.7	-2.7	-2.6	-1.7	-1.9	-2.0	-2.4	-2.3
Ulcerative Colitis (UC)	3.2	6.0	9.9	2.1	2.5	1.1	3.0	-0.8	1.0	3.0	2.4	3.0	3.1	2.7	3.0
Qualifications: College or University degree	3.1	9.7	17.9	2.6	3.4	3.5	3.5	-1.7	1.8	4.2	4.0	3.6	2.4	1.7	3.5
Hand grip strength (left)	3.0	8.0	17.6	1.8	3.1	2.8	3.4	-0.9	1.6	4.2	3.2	3.0	3.0	1.5	3.5
Diabetes (mother)	3.0	3.8	7.1	-1.0	-2.7	-0.4	-2.4	2.4	-0.1	-2.4	-2.3	-1.9	-1.8	-1.0	-2.6
Breast Cancer	2.8	6.7	10.7	-3.3	-3.0	-1.3	-3.0	0.5	-1.7	-3.1	-2.9	-2.8	-2.5	-2.3	-3.1
Ever taken oral contraceptive pill	2.7	3.1	7.1	1.2	1.9	2.2	1.9	-0.5	-0.5	1.9	1.4	2.7	2.3	1.1	2.0
Trunk fat-free mass	2.5	14.1	47.5	5.4	2.2	6.9	2.7	-0.4	3.3	4.7	3.4	4.3	1.0	2.8	2.8
Trunk predicted mass	2.5	14.4	46.8	5.4	2.3	6.8	2.8	-0.5	3.2	4.8	3.5	4.4	1.2	2.8	2.9
Whole body water mass	2.4	13.6	39.3	5.1	2.4	6.3	2.9	-0.3	3.1	4.7	3.6	4.4	1.3	2.9	3.0
Leg fat-free mass (left)	2.3	12.1	24.9	4.4	2.6	5.0	3.2	0.4	2.8	4.5	3.7	4.3	1.9	3.0	3.3
Leg predicted mass (left)	2.3	12.1	23.5	4.4	2.6	4.9	3.2	0.4	2.8	4.5	3.8	4.3	1.9	3.0	3.3
Comparative height size at age 10	2.3	12.8	57.9	5.8	2.0	7.6	1.9	-0.0	1.9	3.6	2.1	3.8	0.6	3.9	1.8
Whole body fat-free mass	2.3	13.2	37.6	5.1	2.4	6.1	2.9	-0.3	3.1	4.6	3.5	4.4	1.3	2.8	3.0
Blood Platelet Count	2.2	25.8	91.2	-5.5	-4.1	-9.6	-3.6	-0.3	-7.1	-6.0	-2.1	-2.6	-1.0	-6.9	-3.5
Medication: Metformin	2.2	3.1	7.8	-2.5	-1.8	-1.1	-1.6	-0.1	-1.0	-1.9	-2.2	-1.5	-1.2	-2.8	-1.6
Heart disease (mother)	2.2	2.6	5.8	-1.3	-1.1	-1.7	-1.6	-0.8	-0.9	-1.9	-2.3	-2.4	-1.2	-1.6	-1.7
Leg fat-free mass (right)	2.2	11.7	30.3	4.5	2.5	5.5	2.9	-0.1	2.5	4.3	3.5	4.2	1.6	3.1	3.0
Hypothyroidism (self reported)	2.1	4.8	11.6	2.4	2.4	0.6	2.3	-0.3	2.1	2.5	2.4	1.8	1.9	3.4	2.4
Frequency of tiredness / lethargy in last 2 weeks	2.1	3.3	7.2	-1.5	-1.3	-0.6	-2.3	-1.3	-2.7	-2.3	-1.9	-1.2	-1.8	-1.6	-2.3
Lung cancer (father)	2.1	2.4	4.7	-1.2	-2.0	-1.3	-2.0	-0.2	-0.4	-1.9	-1.1	-1.4	-2.2	-1.3	-2.0
Arm fat-free mass (right)	2.1	10.7	24.2	4.3	2.2	4.9	2.7	-0.3	3.4	4.2	3.4	4.1	1.2	2.5	2.8
Leg predicted mass (right)	2.1	11.3	29.2	4.4	2.5	5.4	2.8	-0.2	2.3	4.3	3.4	4.2	1.6	3.0	2.9
Basal metabolic rate	2.1	11.6	27.0	4.6	2.4	5.2	2.9	-0.1	3.0	4.5	3.5	4.0	1.5	2.7	3.0
Unable to work because of sickness or disability	2.1	2.7	5.6	-1.6	-1.0	-1.9	-1.4	-1.6	-2.1	-1.7	-1.4	-1.7	-1.0	-2.4	-1.4
Hand grip strength (right)	2.0	5.4	15.9	1.9	2.2	4.0	2.1	-1.8	0.9	3.1	2.2	3.0	2.0	0.5	2.2
Tinnitus: Yes, but not now, but have in the past	2.0	2.1	4.5	-1.1	-1.7	1.1	-1.7	-0.3	-1.4	-1.6	-2.1	-1.4	-1.2	-1.3	-1.7
Average weekly champagne plus white wine intake	2.0	2.7	5.3	-0.1	1.7	0.4	2.2	-1.1	1.2	2.3	2.1	1.8	2.1	0.3	2.3
Loud music exposure frequency	1.9	2.1	4.2	1.4	2.0	-0.1	1.6	-1.3	0.2	1.6	1.6	1.3	1.5	1.4	1.8
Hypothyroidism/myxoedema (self-reported)	1.9	3.6	6.8	2.6	1.9	1.1	1.9	0.2	1.8	2.2	2.1	1.9	1.5	2.5	1.9
Arm predicted mass (right)	1.9	9.9	22.4	4.4	2.1	4.7	2.6	-0.7	3.0	4.1	3.3	4.0	1.1	2.2	2.6
Qualifications: A levels/AS levels or equivalent	1.8	3.9	8.1	0.9	1.2	2.4	2.0	-2.3	-0.5	2.8	1.9	2.8	2.1	0.5	2.1
Forced vital capacity (FVC), Best measure	1.8	6.7	31.8	4.7	1.7	5.6	0.7	-2.3	-1.4	2.1	1.3	2.7	-0.2	1.6	0.6
Basal cell carcinoma (self-reported)	1.8	2.1	9.5	-0.1	0.7	0.9	1.4	3.1	2.0	1.3	0.9	0.4	1.1	1.7	1.4
Intelligence (Savage-Jansen 2018)	1.7	5.2	28.9	1.8	0.8	5.4	1.5	-1.1	2.0	2.7	0.8	1.9	0.9	2.6	1.6
Birth weight	1.7	3.7	10.2	0.7	1.6	0.7	1.9	1.9	3.2	2.1	2.7	1.4	1.4	2.0	1.9
Arm fat-free mass (left)	1.7	8.6	17.6	4.1	2.2	4.2	2.5	-0.5	3.0	3.9	3.0	3.3	1.1	2.2	2.6
Arm predicted mass (left)	1.7	8.4	18.4	4.3	2.1	4.3	2.4	-0.4	2.9	3.8	2.9	3.2	1.0	2.2	2.5
Alzheimer’s Disease (in father)	1.6	1.8	3.4	-0.4	-1.9	0.5	-1.7	1.5	-0.3	-1.9	-1.8	-1.2	-1.2	-0.3	-1.6
Forced vital capacity (FVC)	1.6	6.1	36.9	4.2	1.1	6.1	0.6	-1.7	-1.3	1.9	1.0	2.4	-0.3	1.5	0.6
Medication: Ramipril	1.6	2.0	4.4	-1.1	-2.1	-0.6	-1.9	0.2	-0.5	-1.9	-2.1	-0.8	-1.5	-0.2	-1.9
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.8	4.2	1.8	1.2	1.6	1.4	-1.0	-0.1	1.6	0.9	2.0	1.3	0.9	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	3.9	-0.7	-2.0	-0.0	-1.8	0.6	-0.1	-1.4	-1.5	-1.9	-2.0	-1.3	-1.9
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.3	17.0	3.3	1.3	4.1	1.0	-0.5	-0.2	1.7	1.2	1.6	0.4	0.9	1.1
Ulcerative Colitis	1.5	2.2	4.7	0.8	1.6	0.6	2.0	-0.4	0.4	1.8	1.7	1.9	2.2	0.6	2.0
Type 2 Diabetes (T2D) (2018)	1.5	2.9	6.7	-2.3	-1.9	-0.0	-1.5	-0.8	-2.1	-1.7	-2.6	-0.3	-0.6	-2.4	-1.5
Supplements: Glucosamine	1.5	2.0	6.8	-0.8	-1.3	-0.7	-1.5	-0.5	-2.6	-1.7	-2.0	-1.1	-0.7	-0.8	-1.7
Medication: Atenolol	1.5	1.9	3.3	1.5	1.2	1.8	1.3	-1.6	0.1	1.6	0.9	1.8	1.2	1.2	1.4
Medication: Gliclazide	1.5	1.7	5.1	-2.0	-0.9	-1.0	-0.8	-1.7	-1.2	-1.2	-1.4	-0.3	-0.4	-2.3	-0.7
Verbal and Numeric Reasoning (VNR)	1.4	3.4	10.8	2.2	1.4	3.3	1.6	-2.0	0.4	2.6	0.9	1.6	1.2	1.4	1.7
Medication: Levothyroxine sodium	1.4	2.4	8.3	2.9	1.6	1.6	1.1	-0.5	0.5	1.4	1.0	1.5	0.9	2.4	1.1
Father’s age at death	1.4	1.8	4.8	1.4	0.7	0.8	1.2	1.7	2.2	1.3	1.2	1.3	1.0	1.9	0.9
Happiness	1.4	1.7	2.9	0.4	1.7	-0.3	1.5	-1.0	-0.4	1.6	1.3	1.5	1.6	1.5	1.5
Illnesses of mother	1.4	1.7	3.3	1.2	1.6	1.2	1.5	-0.9	0.3	1.8	1.7	1.0	0.9	1.1	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.4	21.3	4.0	1.0	4.6	0.0	-1.8	-2.0	1.0	0.4	2.1	-0.6	1.0	-0.0
Mouth/teeth dental problems: Loose teeth	1.4	1.6	3.8	1.9	1.8	0.8	1.3	-0.2	0.6	1.5	0.7	0.8	1.1	1.9	1.2
Commuting to job workplace: Walk	1.4	1.5	4.8	-0.7	-1.4	-0.0	-1.4	0.3	0.8	-1.0	-1.3	-2.2	-1.7	-0.9	-1.4
Ovarian Cancer	1.3	1.7	3.3	-1.3	-1.3	-0.3	-1.4	1.6	-0.1	-1.6	-1.8	-1.8	-1.1	-0.1	-1.4
Pain all over the body in last month	1.3	1.4	2.9	-0.5	-0.9	-1.2	-1.4	-0.7	-1.6	-1.6	-0.9	-0.9	-1.7	-0.3	-1.4
Forced expiratory volume in 1-second (FEV1)	1.3	4.3	26.4	3.5	0.5	5.1	-0.1	-1.4	-2.0	1.0	0.2	2.0	-0.5	0.9	-0.0
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.6	2.8	-0.9	-1.0	-0.6	-1.6	-0.8	-0.5	-1.7	-1.2	-1.6	-1.6	-1.5	-1.6
Qualifications: O levels/GCSEs or equivalent	1.3	2.1	5.9	-0.0	1.5	-0.0	1.3	-2.4	-2.1	1.5	1.2	0.6	1.9	-0.8	1.5
Health satisfaction	1.3	1.7	3.7	-0.1	1.4	-1.1	1.5	-1.8	-0.7	1.2	1.3	1.6	1.9	0.5	1.4
Age at last live birth	1.3	2.0	3.9	1.2	1.0	1.9	1.3	0.4	1.7	2.0	1.5	0.9	1.0	1.6	1.5
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.3	3.5	0.3	-1.5	0.2	-1.4	-0.9	-1.9	-1.1	-1.9	-0.6	-1.0	-0.5	-1.1
Qualifications: nursing, teaching	1.3	2.0	4.2	0.6	1.0	1.8	1.3	-1.3	1.3	2.0	2.0	1.9	0.7	-0.3	1.5
Commuting to job workplace: Public transport	1.3	1.5	5.6	-0.3	0.1	2.0	1.1	2.4	1.2	1.5	0.7	0.7	0.9	1.0	1.1
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	5.4	-2.1	-0.8	-1.1	-1.0	-0.2	-2.3	-1.5	-2.3	-0.8	0.0	-1.1	-0.8
Peak expiratory flow (PEF)	1.2	2.8	15.7	2.4	0.1	4.0	0.2	-1.0	-2.1	0.8	-0.6	2.1	0.4	0.9	0.3
Wheeze or whistling in the chest in last year	1.2	2.2	21.1	-0.9	-0.0	-4.6	-0.0	1.1	1.3	-0.7	0.5	-0.7	0.1	0.6	0.1
Pulse rate, automated reading	1.2	3.9	27.2	-3.0	-0.3	-5.2	-0.8	0.4	0.0	-2.0	-0.5	-0.8	-0.5	-1.8	-0.8
Friendships satisfaction	1.2	1.5	4.5	0.1	0.9	0.0	1.6	0.1	-0.2	1.5	1.2	2.1	1.8	0.9	1.5
Tinnitus: Yes, now most or all of the time	1.2	1.4	5.5	1.9	0.1	2.3	-0.1	0.3	1.4	0.5	0.4	-0.6	-0.4	2.1	-0.3
Heart disease (siblings)	1.2	1.4	2.8	-1.1	-1.4	0.5	-1.3	0.8	1.4	-1.1	-0.8	-1.6	-1.7	0.2	-1.3
Ever used hormone-replacement therapy (HRT)	1.1	1.5	6.1	-0.7	-0.7	-0.9	-1.3	0.9	-0.3	-1.4	-1.0	-2.5	-1.5	-0.3	-1.4
Serious illness, injury or assault to yourself	1.1	1.3	3.0	-0.7	-0.6	-0.3	-1.1	-1.2	-1.7	-1.1	-1.2	-1.6	-1.1	-1.2	-1.2
Fluid intelligence score	1.1	2.3	5.8	0.8	1.2	2.4	1.4	-2.3	1.0	2.3	1.0	1.1	1.0	1.0	1.5
Illnesses of siblings	1.1	1.5	5.9	1.6	1.7	-0.4	0.9	-1.6	-2.4	0.8	0.5	1.1	0.9	-0.3	0.8
Weight	1.1	5.5	9.4	2.8	1.8	2.1	2.4	0.9	2.8	3.1	2.6	2.6	1.5	2.2	2.5
Leg fat percentage (right)	1.1	4.0	29.4	-2.9	-0.5	-5.4	0.4	1.6	1.1	-0.9	-0.6	-1.3	1.2	-1.3	0.5
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	5.7	-1.2	0.7	-0.8	0.8	-2.4	-1.8	0.4	0.1	0.9	1.1	-0.9	0.6
Migraine (self-reported)	1.1	1.4	2.5	0.1	1.2	0.2	1.5	-0.2	0.7	1.5	1.2	1.5	1.6	1.1	1.6
Alcohol drinker status: Never	1.1	1.3	3.8	1.9	1.1	-1.2	0.9	1.8	0.3	1.1	1.6	0.3	0.2	0.8	0.7
Leg fat percentage (left)	1.1	4.0	27.6	-3.1	-0.8	-5.2	-0.1	1.4	0.8	-1.3	-1.0	-1.7	0.7	-1.3	0.0
Age at First Birth	1.0	1.4	4.6	2.1	0.8	2.1	0.6	0.2	1.2	1.4	0.9	-0.2	-0.0	1.4	0.5
Bipolar Disorder (2011)	1.0	1.0	2.8	-0.3	-1.2	0.9	-1.4	-1.0	-0.6	-1.1	-0.1	-0.3	-1.7	-0.4	-1.4
Number of treatments/medications taken	1.0	1.8	3.4	-0.8	-1.6	-0.6	-1.8	0.1	-0.7	-1.7	-1.8	-1.4	-1.6	0.3	-1.9
Had menopause	1.0	1.2	2.7	0.0	-1.6	0.3	-1.3	0.8	-0.7	-1.1	-1.5	-1.1	-1.5	-0.0	-1.6
Heart attack	1.0	1.3	2.5	1.1	0.8	-0.4	1.1	1.2	1.5	1.0	0.9	1.6	0.9	1.5	1.0
Depression (self-reported)	1.0	1.2	3.7	0.0	-0.9	0.3	-1.6	1.1	-0.5	-1.4	-0.6	-0.8	-1.9	-0.7	-1.7
Glaucoma (self-reported)	1.0	1.2	6.0	0.5	1.4	-2.5	0.1	-2.1	-0.1	0.1	0.8	-0.9	-0.3	0.1	0.0
Medication: Ibuprofen	1.0	1.2	2.4	-0.4	-0.9	-0.3	-1.5	-0.1	-0.6	-1.5	-1.2	-1.3	-1.2	-0.9	-1.6
Cholesterol lowering medication	1.0	1.5	3.8	0.1	-1.8	0.5	-1.7	-0.5	-0.9	-1.4	-1.3	-0.4	-1.9	0.1	-1.7
Crohns Disease (2017)	0.9	2.1	3.3	0.5	0.9	1.0	1.8	0.9	1.6	1.8	1.5	1.2	1.6	1.8	1.8
Major Depression (MDD)	0.9	1.1	2.7	-1.5	-1.3	0.2	-0.8	1.6	-0.4	-1.2	-1.5	-0.8	-0.5	-0.3	-0.9
Primary Biliary Cirrhosis	0.9	1.3	2.9	0.8	1.0	-0.3	1.4	0.2	0.3	1.3	1.3	1.7	1.5	0.8	1.4
Type 2 Diabetes (T2D) (2012)	0.9	1.0	3.1	-0.5	-0.7	0.5	-1.0	0.9	-1.7	-1.2	-1.3	-0.9	-0.9	-0.5	-1.0
Eye problems/disorders: Diabetes related eye disease	0.9	0.9	2.7	-1.6	-0.4	-1.6	-0.4	-0.7	-1.0	-0.7	-1.1	-1.1	-0.4	-1.1	-0.3
Supplements: Zinc	0.9	1.0	2.8	0.5	0.0	1.7	0.8	1.0	0.7	0.7	0.5	1.4	0.9	1.5	0.8
Medication: Simvastatin	0.9	1.4	2.7	-0.4	-1.6	0.7	-1.6	0.0	-0.1	-1.6	-1.5	-0.5	-1.6	0.2	-1.6
Number of live births	0.9	1.3	2.6	-1.3	-1.6	1.1	-1.4	-0.2	-0.1	-1.3	-1.2	-0.7	-1.1	-1.6	-1.2
Prospective memory result	0.9	1.2	2.8	-0.4	-0.7	-0.7	-1.3	-0.0	-1.2	-1.7	-0.8	-0.8	-1.4	-1.2	-1.5
Blood clot in the leg (DVT)	0.9	1.2	2.5	-1.1	-0.8	-0.1	-1.5	0.3	-0.7	-1.6	-1.1	-0.6	-1.1	-1.2	-1.5
Exposure to tobacco smoke outside home	0.9	1.2	2.8	-1.1	-1.1	-1.7	-1.1	-1.0	0.2	-1.4	-0.4	-0.7	-1.3	-1.3	-1.2
Age at first live birth	0.9	1.5	3.5	0.5	0.8	1.8	1.5	0.1	0.5	1.9	1.0	0.9	1.5	1.3	1.5
Diabetes diagnosed by doctor	0.9	1.6	4.7	-1.8	-1.4	-0.4	-1.1	-0.2	-1.5	-1.4	-2.2	-0.2	-0.3	-1.5	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	4.0	-1.4	-0.3	-2.0	-1.0	-1.2	-0.4	-1.4	-1.4	-1.3	-0.6	-0.4	-1.1
Alzheimer’s Disease (including proxy)	0.8	1.2	3.5	-0.7	-1.9	0.5	-1.1	0.7	1.9	-0.8	-0.8	-1.0	-1.0	0.2	-1.1
Chronotype (morning person)	0.8	1.9	4.8	-2.2	-1.3	-1.1	-1.2	0.9	-1.7	-1.9	-1.6	-0.7	-0.6	-1.4	-1.2
Average weekly spirits intake	0.8	1.0	4.7	0.0	0.4	0.6	1.0	2.2	1.5	1.0	0.3	-0.2	0.8	1.2	0.9
Angina	0.8	1.0	1.8	0.8	1.1	-0.6	1.3	0.2	0.9	1.3	1.1	0.5	1.3	0.8	1.3
Vitamin and mineral supplements	0.8	1.0	3.6	0.9	0.6	1.1	0.9	0.7	1.9	1.3	1.3	0.6	0.5	0.4	1.1
Medication: Co-codamol	0.8	0.9	2.9	-0.2	-1.1	-0.3	-1.4	0.4	-0.1	-1.3	-0.7	-0.5	-1.7	-0.3	-1.4
Diabetes (father)	0.8	1.0	2.2	-0.9	-1.3	0.0	-1.4	0.3	0.4	-1.4	-1.3	-0.6	-0.9	-0.5	-1.5
Average weekly fortified wine intake	0.8	1.0	2.3	-0.9	-0.5	0.2	-0.8	1.1	0.1	-1.1	-1.5	-1.5	-0.7	-1.1	-1.1
Multivitamins +/- minerals	0.8	1.0	2.9	-0.9	-0.7	-0.8	-1.0	-0.0	-1.7	-1.3	-0.7	-1.0	-1.0	-0.7	-1.2
Alcohol usually taken with meals	0.8	1.3	5.0	-0.2	0.7	0.3	1.3	0.5	0.9	1.2	0.9	2.2	1.8	0.6	1.3
Diabetes (self-reported)	0.8	1.2	3.5	-1.9	-0.7	-1.3	-0.6	-0.7	-1.3	-1.1	-1.6	-0.1	0.2	-1.5	-0.6
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	4.2	0.9	0.7	0.5	0.6	-0.2	2.0	1.0	1.8	1.3	-0.0	0.9	0.6
Time employed in main current job	0.8	0.9	3.1	-0.3	1.2	-0.5	1.0	-1.7	0.4	1.1	1.8	-0.4	0.1	-0.1	0.8
Alcohol intake versus 10 years previously	0.8	1.3	3.0	-1.4	-0.6	-1.6	-0.9	-1.5	-1.7	-1.1	-0.7	-0.8	-0.9	-0.4	-0.9
Falls in the last year	0.8	1.1	4.9	-1.9	-0.7	-2.2	0.0	-0.5	-1.1	-0.6	-0.5	0.6	0.7	-1.4	-0.1
Tense / ‘highly strung’	0.8	1.3	2.9	-0.7	-1.1	-0.5	-1.4	0.9	0.1	-1.3	-0.9	-1.7	-1.7	-0.0	-1.4
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.2	0.4	0.6	-1.1	1.1	-0.2	0.2	1.0	1.4	1.5	0.9	0.7	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	2.4	0.4	-1.1	1.3	-1.1	-0.3	-0.7	-0.7	-1.6	-0.8	-0.9	0.9	-1.0
Alcohol intake frequency.	0.8	1.8	5.5	-0.9	-1.2	-2.3	-1.1	0.7	-1.4	-1.8	-1.0	-1.4	-1.1	-0.9	-1.3
Illnesses of siblings: Diabetes	0.8	1.0	2.0	-0.2	-1.2	0.5	-1.3	-0.1	1.0	-1.2	-1.3	-1.2	-1.0	-0.4	-1.4
Heart attack/myocardial infarction (self-reported)	0.8	1.1	1.8	1.0	0.8	-0.7	1.1	1.2	1.3	0.9	0.8	1.4	0.9	1.3	1.0
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	2.3	-1.0	-0.9	-0.0	-1.5	0.4	-0.5	-1.5	-1.0	-0.5	-1.2	-1.2	-1.5
LDL Cholesterol	0.7	1.1	3.3	-1.2	-1.8	0.9	-0.9	0.8	0.2	-0.7	-1.8	-0.7	-0.5	-0.6	-1.0
Pack years adult smoking proportion	0.7	1.1	5.2	-0.6	1.4	-2.3	1.1	-0.5	-0.7	0.5	0.6	0.7	1.3	0.3	1.1
Townsend deprivation index at recruitment	0.7	0.9	3.5	-1.0	1.2	-1.9	0.9	-1.0	0.2	0.7	1.1	0.2	0.5	-0.5	0.9
Relative age voice broke	0.7	1.1	5.7	0.1	-0.3	-0.5	-0.7	-1.9	-2.4	-0.6	-0.8	-0.6	-0.6	-1.3	-0.5
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	2.6	-1.3	1.1	-1.6	0.8	-1.4	-0.3	0.6	0.8	0.9	0.9	-0.1	0.7
Breastfed as a baby	0.7	0.9	3.0	0.2	-1.7	1.3	-0.9	1.3	0.8	-0.5	0.3	0.4	-1.4	-0.4	-0.8
Long-standing illness, disability or infirmity	0.7	1.1	2.6	0.5	0.6	1.2	1.2	0.2	1.0	1.3	0.5	1.2	1.2	1.6	1.0
Smoking status: Current	0.7	1.1	9.3	0.6	1.1	-3.1	0.0	-0.1	-0.4	-0.4	1.2	-0.3	-0.3	0.0	-0.0
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.8	-0.4	-0.7	-1.5	-0.8	-0.3	-1.7	-1.2	-0.6	-0.2	-0.7	0.6	-0.9
Medication: Bendroflumethiazide	0.7	1.0	6.1	0.4	-0.6	1.1	-0.2	0.8	1.9	0.2	-0.2	0.2	-0.3	2.5	-0.1
Medication: Atorvastatin	0.7	0.9	1.7	0.5	0.9	-1.0	1.2	-0.5	0.1	1.1	0.5	0.9	1.3	0.8	1.3
Risk taking	0.7	1.0	3.1	-1.8	-1.3	-0.8	-0.4	0.3	0.5	-0.6	-0.4	-1.5	-0.5	-1.5	-0.5
Age started oral contraceptive pill	0.7	0.9	5.1	0.4	0.5	0.3	0.6	0.5	2.3	0.6	0.9	1.1	-0.1	1.3	0.4
Schizophrenia vs Biploar Disorder	0.6	0.8	4.3	-1.3	0.1	-2.1	0.4	1.3	0.6	-0.4	-0.6	-0.7	0.7	0.1	0.1
Reaction Time	0.6	1.1	3.0	0.3	1.6	-1.2	1.2	0.5	0.6	1.0	1.7	0.7	0.8	0.8	1.2
Blood White Count	0.6	4.5	38.1	-2.1	-0.4	-6.2	-0.9	1.3	0.7	-1.8	0.2	-1.4	-1.1	-0.8	-1.1
Severe depression (siblings)	0.6	0.6	1.5	0.2	0.0	-0.6	0.9	1.2	0.8	0.8	1.2	0.7	0.9	-0.4	0.9
Current tobacco smoking	0.6	0.9	8.4	0.4	0.7	-2.9	-0.2	0.3	-0.7	-0.7	0.8	-0.5	-0.4	-0.1	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.7	3.8	-0.5	0.0	-1.9	-0.7	-0.5	-0.8	-0.9	-0.8	-1.1	-0.4	0.5	-0.7
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.4	1.6	0.4	1.2	0.8	0.9	0.6	0.8	0.7	0.1	0.6	0.8	0.7
Impedance of leg (left)	0.6	3.0	8.5	-1.1	-0.5	-2.9	-1.0	-2.1	-2.8	-1.6	-1.8	-1.3	0.0	-2.0	-1.0
Hip circumference	0.6	2.8	5.2	1.3	1.9	0.3	2.1	0.5	1.7	2.3	2.2	1.6	1.4	1.2	2.1
Ever highly irritable/argumentative for 2 days	0.6	0.8	3.9	-0.1	0.6	0.0	0.9	-0.1	2.0	1.0	0.6	0.9	0.8	0.6	0.9
Medication: Amlodipine	0.6	0.8	1.7	0.2	-0.9	1.2	-1.1	0.3	0.3	-0.6	-1.3	-1.3	-1.2	0.2	-1.0
High blood pressure (siblings)	0.6	0.8	3.6	-1.6	-0.9	-0.3	-0.1	1.3	1.9	0.2	0.5	-0.6	-0.3	-0.3	0.1
Medication for pain relief, constipation, heartburn	0.6	1.0	1.9	0.3	0.7	-0.1	1.1	-0.8	-1.4	1.2	1.2	1.4	1.3	-0.7	1.0
Angina (self-reported)	0.6	0.9	1.8	0.6	1.1	-0.4	1.2	-0.1	0.6	1.2	1.0	0.6	1.3	0.7	1.3
Leg fat mass (right)	0.6	2.4	6.9	-0.6	0.9	-2.6	1.8	1.4	2.2	1.2	1.3	0.9	1.8	0.1	1.9
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.6	1.3	-0.5	0.6	-0.9	0.4	-0.3	-0.7	-1.2	-0.9	-0.7	1.1	-0.8
Medication: Aspirin	0.6	0.8	2.2	0.3	-1.1	-0.2	-1.0	-0.7	0.4	-0.6	-1.2	-1.1	-1.5	0.2	-1.0
Average weekly red wine intake	0.6	0.9	5.8	0.6	0.2	2.4	0.4	-0.3	0.4	0.7	0.1	1.5	0.8	-0.1	0.4
Guilty feelings	0.6	0.9	3.6	-0.4	-0.3	1.8	-0.5	-1.9	-0.8	-0.2	-1.2	-0.6	-0.5	-0.4	-0.5
Eye problems/disorders: Glaucoma	0.6	0.8	4.1	-0.1	1.1	-1.4	0.7	-2.0	-0.2	0.6	0.3	-0.2	0.7	-0.0	0.7
Pack years of smoking	0.6	0.9	5.6	-0.5	1.1	-2.4	0.9	-0.3	-0.5	0.4	0.5	0.6	1.0	0.3	0.9
Alzheimer’s Disease (in mother)	0.5	0.6	3.3	-0.4	-1.3	0.6	-0.5	0.6	1.8	-0.0	-0.0	-0.4	-0.8	0.8	-0.4
Fasting Glucose	0.5	0.5	3.7	-0.5	0.5	-0.3	0.5	1.9	0.8	0.3	-0.2	-0.3	0.8	-0.2	0.7
HbA1C	0.5	0.5	3.5	0.5	1.0	-0.6	0.2	-1.9	-1.0	0.0	0.1	-0.1	0.0	-0.1	-0.2
Triglycerides	0.5	0.9	1.6	-1.0	-0.9	-0.3	-1.0	0.4	-0.5	-1.2	-0.7	-1.2	-1.2	-0.7	-1.3
BMI	0.5	3.1	17.7	-2.8	-0.4	-4.2	-0.0	2.3	1.9	-1.0	0.5	-1.1	-0.0	-0.9	0.0
Impedance of leg (right)	0.5	2.2	8.6	-1.0	-0.3	-2.9	-0.6	-1.4	-2.3	-1.2	-1.4	-1.1	0.4	-2.1	-0.6
Taking other prescription medications	0.5	0.7	1.5	-0.0	-1.2	0.4	-0.9	0.8	0.6	-0.6	-1.1	-1.1	-1.1	0.5	-1.1
Body mass index (BMI)	0.5	2.0	12.2	-1.9	0.0	-3.5	0.5	1.7	2.0	-0.3	0.3	-0.7	0.6	-0.1	0.6
Trunk fat mass	0.5	2.2	3.7	1.2	1.5	-1.1	1.8	1.3	1.6	1.6	1.6	1.3	1.6	1.1	1.9
Qualifications: None of the above	0.5	1.1	3.7	-0.7	-0.3	-1.9	-0.5	1.9	0.8	-1.3	-0.7	-1.0	-0.4	0.5	-0.6
Noisy workplace	0.5	0.6	2.7	0.1	0.1	-0.8	-0.5	0.3	-1.0	-0.8	-1.4	-1.7	-0.2	-0.2	-0.4
Hair/balding pattern: Pattern 4	0.5	1.3	11.6	-1.2	0.3	0.2	0.2	0.7	3.4	0.3	0.2	-0.9	0.0	0.9	0.1
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.4	0.5	0.4	0.5	0.9	-0.3	0.9	1.2	0.4	1.2	1.1	0.9	1.0
Body fat percentage	0.5	2.1	17.6	-1.4	0.4	-4.2	0.8	1.1	0.7	-0.3	0.1	-0.5	1.1	-0.4	0.9
Worry too long after embarrassment	0.5	0.9	3.5	1.9	0.5	1.5	0.2	-0.3	-0.4	0.9	-0.3	-0.7	-0.2	1.6	0.3
Shortness of breath walking on level ground	0.5	0.5	2.5	-0.5	-0.7	-0.7	-0.7	-1.6	-0.0	-0.7	-0.3	-0.0	-0.6	-0.8	-0.8
Emphysema/chronic bronchitis	0.5	0.5	2.9	-0.9	-0.3	-0.5	0.6	-0.6	-0.2	0.2	0.7	1.7	0.7	-0.7	0.6
Mean time to correctly identify matches	0.5	0.9	3.9	0.2	0.8	-0.6	0.8	2.0	1.5	0.6	1.0	0.4	0.4	1.1	0.7
Whole body fat mass	0.5	1.9	3.6	0.5	1.3	-1.9	1.7	1.1	1.7	1.2	1.5	1.0	1.5	0.6	1.8
Number of full sisters	0.5	0.6	2.4	0.5	-0.5	-0.5	0.4	1.6	1.5	0.6	0.7	-0.7	-0.1	0.9	0.4
Overall health rating	0.5	1.1	5.6	-0.1	-0.3	-2.4	-0.8	-0.5	-0.9	-1.1	-1.0	-1.4	-0.8	0.2	-0.9
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.6	-1.0	-0.7	-0.4	-0.8	-0.4	0.3	-0.8	-1.2	-1.0	-0.7	-0.5	-0.8
Loneliness, isolation	0.5	0.7	1.8	0.1	0.9	-0.3	1.0	0.2	0.1	0.9	0.7	1.4	1.2	0.6	1.0
Eye problems/disorders: Cataract	0.5	0.6	1.9	0.9	0.6	0.2	0.6	-0.5	1.4	0.8	1.3	-0.1	-0.1	0.7	0.5
Osteoarthritis (self-reported)	0.5	0.7	1.2	-0.7	-1.0	-0.5	-1.1	0.8	-0.6	-1.1	-1.0	0.3	-1.0	-0.2	-1.1
Medication: Blood pressure	0.5	0.9	3.1	0.5	-0.7	1.8	-0.7	-1.0	0.1	-0.2	-1.1	0.8	-0.6	1.6	-0.5
Illnesses of father: High blood pressure	0.5	0.6	3.4	-0.4	0.6	-1.1	0.6	-1.9	0.1	0.5	0.6	0.7	0.4	0.3	0.6
Alcohol drinker status: Previous	0.5	0.6	3.9	-0.8	-0.2	-2.0	0.2	0.7	0.3	-0.7	0.1	0.7	0.7	0.0	0.0
Leg fat mass (left)	0.5	2.0	6.7	-0.6	0.8	-2.6	1.6	1.3	1.9	1.0	1.1	0.7	1.6	0.2	1.7
Worry (Nagel 2018)	0.4	0.8	1.9	1.2	-0.5	0.3	-1.1	-0.3	-1.4	-0.7	-0.5	-1.1	-1.3	-0.2	-1.0
Mean Putamen Volume	0.4	0.5	2.5	-0.3	-0.7	-1.1	-0.4	1.6	-0.0	-0.3	-0.0	-0.4	-0.8	-0.7	-0.3
Smoking Status	0.4	0.9	5.2	1.2	0.5	-2.3	0.4	0.6	-0.6	0.3	0.7	0.6	0.3	1.5	0.3
Medication for hormone replacement therapy	0.4	0.4	1.7	-0.0	0.8	-1.3	0.3	1.0	-0.6	0.1	0.2	-0.6	0.6	0.5	0.1
Trunk fat percentage	0.4	1.5	11.2	-0.3	1.0	-3.3	1.0	1.1	0.5	0.1	0.4	-0.0	1.3	0.2	1.1
Fed-up feelings	0.4	0.8	4.3	-0.3	0.2	-0.5	-0.2	-2.1	-2.0	-0.4	-0.8	0.1	0.2	-0.0	-0.1
Chronic bronchitis/emphysema (father)	0.4	0.5	1.5	-0.8	-0.8	-0.3	-0.5	-1.0	-0.8	-0.7	-1.2	0.8	-0.2	0.1	-0.6
Past tobacco smoking	0.4	0.7	2.1	-0.8	-0.7	0.3	-0.8	0.9	0.3	-1.1	-0.2	-0.9	-0.9	-1.4	-0.8
Had other major operations	0.4	0.5	4.4	-0.7	-0.5	-0.7	-0.0	2.1	-0.4	-0.1	-0.6	-0.2	0.1	0.1	-0.2
Financial difficulties in last 2 years	0.4	0.6	2.0	-1.4	-0.7	-1.2	-0.3	-0.8	-0.7	-0.5	0.2	0.1	-0.1	-1.3	-0.2
Arm fat percentage (right)	0.4	1.6	11.0	-1.6	0.2	-3.3	0.5	1.7	0.9	-0.5	-0.2	-0.9	0.8	0.1	0.6
Pulse rate	0.4	0.7	2.2	-1.3	-0.7	-1.5	-0.7	0.4	0.3	-0.9	-0.2	0.2	-0.6	-1.3	-0.7
Arm fat mass (right)	0.4	1.7	3.5	0.2	1.2	-1.5	1.6	1.4	1.9	1.2	1.2	0.6	1.3	1.1	1.6
Pulse wave reflection index	0.4	0.5	2.4	0.2	-0.3	1.6	-0.4	0.3	-0.3	0.1	-0.8	-1.1	-0.7	-0.9	-0.3
Medication: Paracetamol	0.4	0.6	1.9	-0.1	0.4	-1.0	-0.7	0.7	1.4	-1.0	-0.5	-1.2	-0.6	0.5	-0.7
Gout (self-reported)	0.4	0.6	4.2	-0.4	0.5	-1.1	0.4	-0.7	-2.1	0.0	0.1	0.1	0.7	-0.4	0.2
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.1	-0.4	-0.8	0.4	-0.9	0.6	0.5	-1.1	-0.4	-0.2	-0.9	-0.8	-0.9
Eye problems/disorders: None of the above	0.4	0.5	2.8	-1.0	-0.8	0.6	-0.4	1.7	-0.4	-0.5	-0.4	0.7	0.1	-0.3	-0.3
Medication: Omeprazole	0.4	0.5	2.3	0.0	-1.0	0.6	-0.6	-0.7	-0.3	-0.9	-1.5	0.0	0.1	0.2	-0.6
Medication: Seretide 50 evohaler	0.4	0.4	1.2	-0.6	0.4	1.1	0.7	-0.7	-0.3	0.6	0.2	0.4	1.0	0.5	0.6
Suffer from ‘nerves’	0.4	0.6	1.9	0.8	0.5	-0.1	0.8	0.3	0.5	0.9	1.4	1.0	0.4	0.4	0.8
Illnesses of father: Heart disease	0.4	0.5	2.2	0.7	0.9	-0.8	0.6	0.1	0.8	0.5	1.5	0.5	0.3	0.7	0.6
Arm fat percentage (left)	0.4	1.6	10.2	-1.7	-0.0	-3.2	0.5	2.0	1.0	-0.4	0.0	-0.4	0.9	0.2	0.7
Mood swings	0.4	0.8	3.0	-0.5	-0.2	-1.0	-0.9	-1.7	0.3	-0.9	-0.8	-1.1	-0.8	-0.3	-0.9
Medication for cholesterol	0.4	0.6	3.8	-1.2	0.2	-0.8	0.4	0.3	0.1	0.0	0.6	-0.6	0.3	-1.9	0.3
Mineral and other dietary supplements	0.4	0.5	2.2	0.1	0.7	-0.3	0.5	-0.1	1.5	0.8	0.8	-0.1	0.2	-1.0	0.6
Breast cancer (self-reported)	0.4	0.5	1.9	-0.7	-0.7	1.2	-0.1	1.4	1.2	0.3	0.1	-0.0	-0.4	0.4	-0.1
Medication: Aspirin	0.4	0.5	1.7	0.3	-0.9	-0.4	-0.8	-0.7	0.1	-0.5	-0.8	-0.9	-1.3	0.3	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	3.2	1.4	0.8	0.0	-0.2	-1.6	-1.8	-0.0	0.9	0.8	-0.5	-0.6	-0.3
Arm fat mass (left)	0.4	1.7	3.5	0.3	1.1	-1.3	1.5	1.4	1.9	1.2	1.3	0.9	1.3	1.1	1.6
Wears glasses or contact lenses	0.4	0.5	1.6	-0.2	0.4	-1.2	0.7	0.3	-0.8	0.5	0.2	0.7	1.0	0.5	0.7
Mother’s age at death	0.4	0.5	3.8	-0.4	-0.6	-0.5	-0.2	1.9	0.8	0.1	0.7	0.1	-0.6	0.4	-0.3
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.5	-1.2	-0.2	-1.1	0.1	0.3	-0.7	-0.3	-1.1	-0.3	0.7	-0.6	-0.0
Average weekly beer plus cider intake	0.4	0.5	3.1	0.6	0.4	0.2	-0.1	-1.6	-1.8	-0.0	-0.0	0.2	-0.2	-0.4	-0.1
Fractured/broken bones in last 5 years	0.4	0.5	1.8	0.1	-1.3	1.0	-0.9	-0.2	0.1	-0.7	-0.0	0.3	-1.1	0.2	-0.8
Commuting to job workplace: Cycle	0.4	0.5	1.4	0.8	0.4	1.2	0.5	-0.9	-0.5	1.0	0.3	1.1	0.0	-0.6	0.6
Myopia	0.4	0.6	1.9	0.4	0.7	0.4	0.6	0.6	-1.2	0.6	0.1	1.4	0.9	0.5	0.6
Supplements: Calcium	0.4	0.5	3.7	-0.1	-0.4	0.1	0.2	1.9	-0.0	0.1	0.8	0.8	0.0	0.5	0.2
Bipolar Disorder (2018)	0.3	0.4	1.1	-1.0	-0.8	0.7	-0.4	1.1	-1.1	-0.4	-0.6	-0.1	-0.3	-0.4	-0.1
Depressed Affect (Nagel 2018)	0.3	0.6	4.2	0.4	0.5	-0.5	-0.0	-2.0	-1.3	-0.1	-0.7	-0.3	0.4	0.5	0.0
Neuroticism (Nagel 2018)	0.3	0.7	3.4	1.4	0.7	0.4	0.1	-1.8	-1.4	0.4	-0.4	-0.4	0.0	0.7	0.1
Coronary Artery Disease (CAD)	0.3	0.3	1.4	-0.4	0.2	0.7	0.5	1.2	0.5	0.1	0.0	0.6	0.5	0.7	0.4
Crohns Disease (2012)	0.3	0.4	1.4	-0.1	0.1	1.2	0.6	0.3	1.0	0.6	0.4	0.4	0.5	1.1	0.6
Lupus	0.3	0.5	2.4	1.5	0.2	-0.4	0.3	0.4	0.8	0.3	1.1	0.3	-0.2	0.8	0.3
Rheumatoid Arthritis	0.3	0.4	2.2	0.8	-0.2	0.8	0.2	1.5	0.2	0.3	0.2	0.4	-0.1	1.1	0.3
Cardiovascular Disease	0.3	0.9	2.6	0.2	-0.7	1.6	-0.4	-1.5	-0.6	-0.1	-1.6	0.6	0.2	1.1	-0.2
Lung FVC	0.3	1.3	3.0	-0.2	-0.6	-0.8	-1.4	-0.5	-1.7	-1.4	-0.7	-1.3	-1.7	-0.5	-1.6
Tanning	0.3	3.8	7.5	1.6	1.7	-0.6	2.1	-1.9	-2.6	2.1	1.5	2.7	2.2	1.1	2.1
Hearing difficulty/problems: Yes	0.3	0.5	1.2	-0.4	0.5	-0.6	0.9	0.4	0.9	0.6	1.1	0.6	0.7	0.4	0.8
Maternal smoking around birth	0.3	0.4	1.8	-0.8	-0.1	-1.4	0.5	0.8	0.6	0.1	0.5	0.7	0.5	-0.1	0.3
High blood pressure	0.3	0.8	4.1	0.5	-0.5	2.0	-0.2	-0.6	0.5	0.1	-1.2	1.0	0.3	1.5	-0.1
High blood pressure (mother)	0.3	0.4	1.8	-0.4	0.3	-0.6	0.7	0.7	0.4	0.2	-0.3	1.0	1.4	-0.0	0.7
Hearing difficulty/problems with background noise	0.3	0.4	1.4	-0.2	-0.2	-0.6	-0.4	0.6	1.2	-0.5	-0.6	-0.5	-0.3	1.2	-0.5
Mouth/teeth dental problems	0.3	0.4	2.1	1.4	-0.2	1.1	-0.1	0.7	-0.0	0.1	0.7	0.5	-0.2	-0.2	-0.1
Mouth/teeth dental problems: Dentures	0.3	0.5	3.2	-1.5	0.1	-1.8	0.0	0.3	-0.6	-0.6	-0.1	-0.1	0.3	-0.6	0.0
Exposure to tobacco smoke at home	0.3	0.4	1.5	-0.9	-0.4	-0.8	-0.2	-0.7	-0.5	-0.5	0.1	0.2	-0.5	-1.2	-0.3
Birth weight of first child	0.3	0.6	2.6	-0.9	0.4	-0.5	0.0	-1.6	0.2	-0.1	0.7	0.9	0.0	-1.2	-0.0
Neck or shoulder pain in last month	0.3	0.4	1.9	0.4	1.0	-0.6	0.4	-1.4	0.3	0.2	-0.0	0.0	0.6	0.6	0.3
Medication: Allopurinol	0.3	0.4	3.3	0.0	-0.1	-1.1	0.1	-0.4	-1.8	-0.0	-0.2	-0.6	0.2	-0.2	0.1
Chest pain or discomfort	0.3	0.5	2.4	-0.2	-0.6	-1.6	-0.5	0.3	1.1	-0.5	-0.1	-0.7	-0.6	0.2	-0.6
Family relationship satisfaction	0.3	0.4	2.9	-0.2	0.1	0.8	0.1	0.3	-0.0	0.4	-0.6	0.7	0.4	1.7	0.3
Leg pain on walking	0.3	0.3	1.2	-0.1	0.1	-0.6	0.5	0.7	0.7	0.2	0.0	0.7	0.9	1.1	0.4
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.3	-0.8	-0.1	-1.0	-0.2	-0.9	-1.1	-0.5	-0.5	0.0	0.4	-0.6	-0.1
Knee pain experienced in last month	0.3	0.5	2.5	-0.0	-0.2	0.4	0.5	1.1	0.2	0.3	0.5	1.6	0.8	0.6	0.4
Hypertension (Self-reported)	0.3	1.0	3.6	0.0	-1.2	1.9	-0.9	-0.7	-0.0	-0.6	-1.8	0.5	-0.4	0.8	-0.8
Smoking status: Previous	0.3	0.5	2.5	0.6	-0.1	0.9	0.5	0.2	-0.1	0.9	-0.5	0.6	0.7	1.6	0.5
Ever had bowel cancer screening	0.3	0.4	1.3	-0.0	-0.8	0.2	-0.2	1.1	-0.6	-0.5	-1.1	-0.7	-0.0	0.2	-0.3
Osteoporosis (self-reported)	0.3	0.4	0.9	-0.4	-0.6	-0.9	-0.7	0.5	-0.2	-0.6	-0.5	-0.8	-0.9	-0.5	-0.8
Illnesses of father: None of the above (group 1)	0.3	0.4	2.3	0.2	0.0	0.4	0.2	1.5	-0.0	0.3	-0.2	-1.1	0.0	-0.7	0.2
Miserableness	0.3	0.5	2.3	-0.5	0.2	-1.5	-0.1	-1.3	-0.8	-0.2	-0.2	-0.6	0.1	-0.5	-0.0
Financial situation satisfaction	0.3	0.4	1.5	0.1	-0.0	-0.6	0.2	0.8	-0.8	-0.2	-0.2	1.2	0.8	0.9	0.2
Medication: Paracetamol	0.3	0.4	1.0	0.1	0.4	-0.6	-0.5	1.0	0.9	-0.7	-0.4	-1.0	-0.4	0.5	-0.5
Medication: Lisinopril	0.3	0.3	1.3	0.9	-0.4	0.4	0.2	0.8	1.1	0.3	0.4	-0.0	0.1	0.8	0.3
Number of operations (self-reported)	0.3	0.4	1.3	1.0	0.3	1.1	0.4	1.1	0.4	0.8	-0.0	-0.2	0.1	0.7	0.3
Irritability	0.3	0.4	1.1	0.2	0.1	0.4	-0.7	-1.0	-0.4	-0.6	-1.1	-1.1	-0.5	0.1	-0.6
Impedance of whole body	0.3	1.3	9.8	0.2	0.1	-1.1	-0.5	-1.1	-3.1	-0.9	-1.1	-0.6	0.4	-0.6	-0.5
Bipolar Disorder or Schizophrenia	0.2	0.5	1.7	-1.3	-0.4	-0.6	-0.5	1.1	-0.7	-0.9	-0.5	-0.6	-0.6	-0.2	-0.4
Schizophrenia (2018)	0.2	0.4	1.6	-0.9	0.1	-1.3	-0.4	0.6	-0.1	-0.9	-0.1	-0.5	-0.6	0.1	-0.5
Body Mass Index (BMI) (2010)	0.2	0.3	0.7	0.0	0.6	0.6	0.6	0.2	-0.8	0.6	0.5	0.7	0.6	0.2	0.5
Schizophrenia (2014)	0.2	0.5	1.1	-0.9	-0.6	-0.5	-0.7	0.6	0.0	-1.0	-0.8	-0.6	-0.7	0.3	-0.7
Allergy or Eczema	0.2	0.5	1.3	-0.7	1.0	-0.6	0.7	-0.7	-1.1	0.4	0.9	0.8	0.6	-0.3	0.8
Lung FEV1/FVC ratio	0.2	1.0	4.5	0.8	-0.3	-1.7	-0.9	-0.0	-2.1	-1.2	-0.8	0.2	-0.7	-0.1	-0.9
Frequency of depressed mood in last 2 weeks	0.2	0.2	1.1	-0.2	0.0	-1.0	-0.3	0.1	-0.2	-0.3	-0.3	-0.1	-0.2	1.0	-0.2
Relative age of first facial hair	0.2	0.4	1.4	-1.0	-1.0	-0.7	-0.4	0.1	-1.2	-0.5	-0.2	-0.2	-0.3	-0.9	-0.1
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.7	-0.6	-0.6	0.8	-0.3	-0.2	0.5	-0.2	-0.3	-0.5	-0.4	-0.1	-0.4
Age when periods started (menarche)	0.2	0.4	1.8	0.2	0.5	0.4	0.6	0.2	-1.3	0.9	0.2	0.4	0.3	-0.4	0.7
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.3	-0.7	0.9	-1.1	0.5	-1.0	-1.1	0.1	0.6	0.6	0.5	-0.3	0.6
Stomach or abdominal pain in last month	0.2	0.2	0.8	0.7	0.4	-0.0	0.5	-0.2	0.1	0.5	-0.4	-0.2	0.7	0.9	0.5
Waist circumference	0.2	0.8	3.2	0.1	0.2	-1.5	0.8	1.0	1.8	0.8	0.7	0.2	0.4	0.4	0.8
Number of incorrect matches in round	0.2	0.3	1.5	-0.1	0.5	-0.2	0.2	0.1	1.2	-0.0	1.1	0.8	-0.4	0.2	0.0
Nervous feelings	0.2	0.4	1.1	-0.0	0.6	-0.1	0.7	0.1	-0.9	0.6	1.1	1.0	0.7	-0.0	0.7
Hair/balding pattern: Pattern 2	0.2	0.3	1.3	-0.6	-0.7	0.0	0.1	1.1	-0.7	0.1	0.1	0.7	0.1	-0.3	0.2
Allergy	0.2	0.4	1.6	0.6	-0.9	1.3	-0.3	1.0	0.5	0.2	-0.5	-0.4	-0.3	0.1	-0.3
Neuroticism score	0.2	0.4	1.0	0.0	-0.3	0.1	-0.7	-1.0	-1.0	-0.5	-0.5	-1.0	-0.7	-0.4	-0.7
Impedance of arm (right)	0.2	1.1	11.1	0.9	0.4	0.2	-0.1	-0.5	-3.3	-0.4	-0.8	-0.3	0.4	0.2	-0.2
Worrier / anxious feelings	0.2	0.4	1.7	1.2	-0.2	1.3	-0.5	-0.7	-0.2	-0.0	0.2	-0.4	-0.7	0.4	-0.5
Medication: Lansoprazole	0.2	0.2	1.1	-0.3	0.0	-0.1	0.5	1.0	0.1	0.5	-0.2	0.1	0.6	0.5	0.5
Impedance of arm (left)	0.2	1.0	8.7	1.2	0.3	0.7	-0.0	0.0	-2.9	-0.2	-0.5	0.3	0.5	0.5	0.0
Length of working week for main job	0.2	0.2	1.9	-0.4	-0.7	0.5	-0.2	-0.1	-1.4	-0.2	0.0	0.2	-0.2	-0.3	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.7	-0.1	0.8	0.3	0.4	-0.7	-0.3	0.6	0.2	0.8	0.4	0.3	0.5
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.9	-0.9	0.0	-0.8	-0.2	0.1	0.0	-0.2	-0.4	-0.8	-0.2	-0.9	-0.2
Comparative body size at age 10	0.2	0.5	2.5	-1.2	0.1	-0.3	-0.1	0.8	1.6	-0.3	-0.3	-1.0	-0.3	0.4	-0.2
Number of full brothers	0.2	0.3	1.4	0.3	-0.1	0.5	-0.2	1.0	0.6	-0.3	-0.3	0.2	-0.2	1.2	-0.2
Number of children fathered	0.2	0.3	2.2	-0.2	-0.6	0.4	-0.1	1.5	0.4	0.0	0.1	0.2	0.2	0.5	-0.2
Medication: Blood pressure	0.2	0.4	1.3	0.0	-0.8	1.1	-0.2	0.8	1.1	0.0	-0.3	0.2	-0.3	0.4	-0.3
Had major operations	0.2	0.2	0.9	-0.2	0.1	0.9	0.3	-0.8	-0.3	0.7	-0.3	0.1	0.6	-0.4	0.3
Supplements: Vitamin C	0.2	0.3	1.0	-0.7	-0.4	-0.1	-0.5	0.3	-0.8	-0.7	-1.0	0.2	0.0	0.2	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.9	-0.6	-1.0	-0.5	-0.4	-0.4	0.5	-0.5	-0.7	-0.3	-0.1	0.1	-0.4
Asthma (self-reported)	0.2	0.3	0.9	1.0	-0.1	0.2	-0.5	-0.0	0.8	-0.3	0.1	0.0	-0.8	0.8	-0.6
Number of self-reported non-cancer illnesses	0.2	0.3	0.9	0.2	-0.6	0.9	-0.5	0.8	0.3	-0.3	-0.5	-0.3	-0.6	0.9	-0.5
High cholesterol (Self-reported)	0.2	0.3	0.5	0.5	-0.7	0.5	-0.6	0.2	-0.5	-0.6	-0.6	0.1	-0.5	0.6	-0.7
Ever smoked	0.2	0.4	1.5	-0.1	0.3	-1.2	0.1	-1.2	-1.1	0.2	0.4	0.3	0.1	0.2	0.2
Ever depressed for a whole week	0.2	0.3	1.6	-0.0	0.4	-0.0	0.5	-0.4	-0.5	0.4	0.3	1.3	0.6	0.3	0.4
Vascular/heart problems diagnosed by doctor	0.2	0.6	2.7	-0.8	0.2	-1.2	-0.1	0.6	-0.5	-0.4	0.9	-0.6	-0.4	-1.6	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	1.4	-0.1	-0.5	0.5	-0.1	-0.3	0.2	-0.5	-1.2	0.3	0.5	0.8	-0.1
Depression (Nagel 2018)	0.1	0.1	0.5	-0.0	-0.0	-0.5	-0.4	0.1	-0.7	-0.4	-0.5	-0.4	-0.2	0.4	-0.2
HDL Cholesterol	0.1	0.2	2.0	0.1	0.5	-1.4	-0.0	-0.2	-0.3	-0.1	0.2	-0.1	0.0	0.0	0.3
Neuroticism (2016)	0.1	0.2	0.9	0.0	0.7	0.4	0.3	0.0	-0.1	0.2	1.0	0.1	-0.1	0.1	0.3
Blood Eosinophil Count	0.1	1.0	6.1	-0.8	0.8	-2.5	0.7	1.1	-0.1	-0.0	1.2	0.5	1.1	0.6	0.6
Blood Red Count	0.1	1.0	2.4	0.9	1.3	0.4	1.1	-0.7	0.8	1.6	0.1	-0.1	1.4	1.2	1.2
Waist Hip Ratio (WHR)	0.1	0.5	1.6	0.9	-0.7	-0.4	-0.3	-1.2	-0.1	-0.0	-1.1	-1.3	-0.0	0.2	-0.2
Systolic Blood Pressure	0.1	0.7	3.0	1.3	0.1	1.7	0.4	-0.1	0.8	0.6	-0.1	1.2	0.8	0.5	0.5
Respiratory disease	0.1	0.1	0.4	0.2	0.5	0.5	0.3	-0.2	0.0	0.3	0.6	-0.1	0.2	0.1	0.2
Neuroticism	0.1	0.3	1.3	0.5	0.2	0.5	-0.4	-0.9	-0.5	-0.1	-0.6	-1.1	-0.5	0.2	-0.5
Sensitivity / hurt feelings	0.1	0.3	1.3	0.9	0.2	0.4	-0.3	0.3	-1.1	-0.1	-0.1	-0.5	-0.3	0.0	-0.3
Ever had hysterectomy (womb removed)	0.1	0.1	0.4	0.5	0.2	0.5	0.2	-0.1	-0.5	0.1	0.4	-0.6	-0.2	0.6	0.0
Systolic blood pressure, automated reading	0.1	0.4	1.5	0.2	-0.6	-0.8	-0.6	1.2	0.5	-0.8	-0.4	-0.6	-0.5	-0.6	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	1.3	0.5	-0.8	-0.4	-0.4	1.1	0.0	-0.6	-0.7	-0.5	0.1	0.3	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	1.6	0.4	-0.5	-0.2	-0.1	1.3	0.1	-0.4	-0.4	-0.1	0.4	0.5	-0.0
Hair/balding pattern: Pattern 3	0.1	0.2	0.6	-0.2	-0.5	-0.1	-0.5	-0.8	-0.5	-0.2	-0.2	-0.2	-0.6	-0.6	-0.6
Asthma	0.1	0.3	0.9	1.0	-0.1	0.3	-0.4	-0.3	0.7	-0.3	0.1	0.1	-0.5	0.8	-0.5
Medication: Cholesterol lowering	0.1	0.2	0.7	-0.0	-0.3	0.3	-0.1	0.6	-0.9	-0.3	-0.3	0.2	0.3	0.4	-0.1
Pulse wave Arterial Stiffness index	0.1	0.1	0.4	0.6	0.3	0.2	0.4	-0.3	0.5	0.6	0.3	0.4	0.3	-0.1	0.4
Headache pain in last month	0.1	0.2	0.4	-0.6	-0.1	-0.6	-0.5	-0.6	-0.4	-0.6	-0.5	-0.6	-0.5	-0.3	-0.3
Pulse wave peak to peak time	0.1	0.1	0.4	-0.0	-0.2	0.7	-0.3	0.2	-0.5	-0.2	-0.1	0.1	-0.3	0.3	-0.2
Back pain experienced in last month	0.1	0.2	0.8	0.5	0.3	0.9	-0.2	0.4	0.6	-0.3	-0.1	0.2	-0.1	0.5	-0.5
Hearing aid user	0.1	0.1	0.3	0.1	0.3	-0.4	-0.2	-0.5	0.4	-0.2	-0.3	-0.1	-0.2	0.5	-0.2
Diastolic blood pressure, automated reading	0.1	0.4	2.7	-0.3	0.6	-1.6	0.2	0.8	0.5	-0.2	0.1	-0.2	0.4	-0.8	0.3
Pain experienced in last month	0.1	0.1	0.5	0.2	-0.0	-0.1	0.2	0.4	0.1	0.5	0.1	-0.7	-0.0	-0.2	0.3
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Heel T-Score	0.0	0.2	0.9	0.9	0.5	-0.0	-0.1	0.0	-0.9	-0.0	0.4	0.1	-0.0	0.1	-0.0
Hair Pigment	0.0	0.3	0.9	-0.7	-0.1	-1.0	-0.1	-0.9	0.3	-0.3	0.0	-0.7	-0.3	-0.7	-0.2

Hub : Genes

HSD17B3

Models

Trait associations