TWAS
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Models
Genes
Traits
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Traits
:
Diastolic blood pressure, automated reading
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chr19:29,606,361-31,013,761
Best TWAS P=3.56e-19 · Best GWAS P=6.28e-19 conditioned to 0.0646
29.6M
29.8M
30M
30.2M
30.4M
30.6M
30.8M
31M
0
5
10
15
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
The Cancer Genome Atlas
Brain Lower Grade Glioma
CCNE1
0.03
0.03
enet
5
0.03
3.2e-04
8.8
-8.9
3.6e-19
-0.91
0
0.99
TRUE
2
GTEx
Skin Sun Exposed Lower leg
CCNE1
0.27
0.22
lasso
8
0.24
2.5e-19
8.8
8.4
5.9e-17
0.93
0
1.00
FALSE
3
The Cancer Genome Atlas
Bladder Urothelial Carcinoma
CCNE1
0.03
0.02
blup
39
0.02
4.5e-03
8.8
8.2
2.6e-16
0.90
0
0.97
FALSE
1
GTEx
Skin Not Sun Exposed Suprapubic
CCNE1
0.31
0.19
lasso
9
0.21
6.3e-12
8.8
7.9
2.5e-15
0.94
0
1.00
FALSE