Hub : Traits :

Diastolic blood pressure, automated reading

2121 significantly associated models · 448 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	7686056	9571422	3	1	4.8e-15	8.8e-13	3.5e-01	98	RERE
2	1	11032827	12600396	5	10	7.6e-35	3.6e-32	NaN	NaN	C1orf167 CLCN6 MTHFR
3	1	37730550	39147240	1	1	4.0e-08	1.4e-07	1.5e-02	78	SF3A3
4	1	41253185	41957439	1	1	1.8e-07	2.0e-07	3.0e-02	83	SCMH1
5	1	43073464	44618031	10	1	1.7e-11	9.3e-11	3.6e-02	90	HYI
6	1	112312154	114366434	8	2	1.7e-13	1.2e-13	4.5e-08	46	SLC16A1 WNT2B
7	1	183961643	185416670	1	1	3.7e-08	1.5e-06	6.3e-01	99	EDEM3
8	1	201158976	202607593	3	1	1.0e-09	7.0e-13	3.3e-09	32	LMOD1
9	1	230142626	231548480	1	1	3.6e-16	8.9e-13	4.9e-01	99	AGT
10	1	242590540	244359621	3	1	3.8e-22	3.8e-22	1.0e+00	100	RP11-261C10.5
11	2	73169500	74565186	2	1	3.5e-08	1.2e-07	3.4e-01	97	NAT8
12	2	95420294	98024837	16	1	1.5e-13	3.0e-13	1.0e+00	100	ADRA2B
13	2	112143413	113572357	1	1	1.9e-08	3.9e-09	4.9e-04	65	TMEM87B
14	2	134513621	137435625	6	1	5.2e-09	4.5e-08	9.2e-01	100	LOC100129961
15	2	147905651	149475737	3	1	6.7e-08	5.8e-08	1.0e+00	100	ACVR2A
16	2	158332890	160006143	2	1	2.4e-10	8.2e-12	9.9e-03	86	CCDC148
17	2	171867383	173555880	3	1	5.8e-09	5.3e-09	1.0e+00	100	DYNC1I2
18	2	182305254	184084221	1	1	2.3e-11	1.7e-17	2.1e-08	57	PDE1A
19	2	189930854	192525536	7	2	5.0e-12	1.1e-07	6.5e-01	99	GLS MSTN
20	3	40537829	42967174	3	2	2.5e-23	6.9e-21	1.0e+00	100	CTNNB1 ULK4
21	3	47204518	50833360	23	2	3.3e-14	3.3e-11	7.0e-01	100	NME6 RNF123
22	3	57294295	58854266	2	1	3.7e-12	1.7e-11	2.2e-01	97	FLNB
23	3	107181540	108633112	1	1	2.8e-07	1.7e-07	1.0e+00	100	IFT57
24	3	121346656	122821385	4	1	3.5e-08	9.3e-09	5.7e-05	51	CSTA
25	3	123792729	125314016	1	1	2.4e-10	2.4e-09	4.9e-01	99	ITGB5
26	3	133088362	134770520	2	2	1.4e-07	4.2e-08	3.2e-01	97	RPL39P5 RYK
27	3	157125828	159106064	3	1	1.2e-10	1.6e-09	7.4e-01	100	RSRC1
28	4	17104059	18507692	2	1	8.4e-10	4.0e-08	1.1e-01	92	DCAF16
29	4	80488345	82578407	2	1	2.5e-10	2.3e-34	7.5e-26	26	C4orf22
30	4	101698032	102513322	1	1	3.0e-09	6.5e-10	1.4e-02	84	PPP3CA
31	4	102868793	104374596	1	1	6.4e-08	1.6e-19	4.8e-21	-9	MANBA
32	4	119605671	120922444	1	1	2.2e-07	2.2e-08	4.9e-03	75	C4orf3
33	5	60903201	62529686	3	1	4.9e-12	2.3e-11	1.0e+00	100	IPO11
34	5	87104604	88677293	1	1	1.3e-08	6.3e-09	1.9e-01	95	LINC00461
35	5	95519506	97065386	2	1	1.7e-09	9.6e-09	6.9e-01	100	ERAP2
36	5	122045488	123649166	3	1	3.9e-13	2.9e-13	1.4e-03	81	KRT8P33
37	5	172620700	174088123	1	1	4.7e-17	1.5e-17	1.0e+00	100	CPEB4
38	6	25285943	26689223	1	1	1.9e-10	2.6e-15	4.2e-12	23	U91328.21
39	6	51230788	52198802	1	1	9.0e-09	2.5e-13	5.9e-06	62	PKHD1
40	6	78880271	81763771	4	3	2.8e-12	1.7e-12	8.7e-02	94	BCKDHB IRAK1BP1
41	6	108994161	110396540	1	1	2.2e-07	2.1e-08	1.3e-03	67	CD164
42	6	118089396	119728438	2	1	3.7e-08	3.8e-08	2.4e-01	95	CEP85L
43	6	146826657	148410391	2	1	4.3e-09	4.0e-08	2.5e-01	96	STXBP5
44	7	6502367	7988091	1	1	3.8e-09	2.6e-08	4.8e-01	98	C1GALT1
45	7	27049529	27533292	1	1	2.0e-07	4.0e-09	2.5e-03	74	EVX1
46	7	45709404	46210616	1	1	1.3e-07	8.6e-13	1.3e-06	54	IGFBP3
47	7	73017005	75842792	9	2	4.8e-11	8.4e-08	3.3e-01	97	NCF1 STAG3L1
48	7	89096541	90699073	4	1	4.9e-11	1.9e-10	4.8e-01	99	STEAP1
49	7	98915958	101185166	14	8	1.7e-14	1.3e-12	1.0e+00	100	ACHE GIGYF1 STAG3 TRIP6 ZKSCAN1
50	7	149563894	150920503	2	1	1.3e-10	1.5e-11	8.0e-09	27	GIMAP7
51	8	8092025	13120332	37	2	2.7e-19	4.1e-19	9.0e-03	91	MSRA NEIL2
52	8	22687572	24094711	1	1	4.0e-08	8.0e-08	2.2e-01	95	SLC25A37
53	8	95139766	96825195	4	1	5.1e-10	3.9e-10	2.9e-02	88	C8orf38
54	8	119737284	121136001	1	1	1.0e-17	6.1e-18	1.0e+00	100	NOV
55	9	135883620	136399075	1	1	1.9e-10	2.2e-10	3.8e-03	79	ABO
56	9	138875850	140268976	1	1	3.1e-07	1.7e-10	6.4e-11	-5	AGPAT2
57	10	18221643	19637020	2	2	6.0e-11	3.2e-17	2.4e-14	18	CACNB2 NSUN6
58	10	21123825	22724472	1	1	2.9e-08	5.5e-08	6.3e-02	88	MLLT10
59	10	63856856	66034105	5	3	1.8e-21	7.4e-17	2.0e-01	98	NRBF2 REEP3 RP11-436D10.3
60	10	95379543	96818402	1	1	5.2e-10	1.0e-13	1.3e-06	57	NOC3L
61	10	103572925	105850787	6	1	2.4e-17	9.5e-17	4.3e-02	94	NT5C2
62	10	114740745	116183647	3	3	2.6e-17	7.0e-22	8.3e-09	64	ADRB1 C10orf118 CASP7
63	11	1242690	2640824	3	3	5.1e-12	2.4e-11	NaN	NaN	LSP1 TNNI2 TNNT3
64	11	9003306	11027552	2	2	1.1e-12	5.5e-15	2.2e-02	91	ADM SWAP70
65	11	12611333	14105497	1	1	9.5e-08	5.5e-10	5.4e-04	69	ARNTL
66	11	46570859	48783497	10	1	1.4e-10	4.7e-10	8.0e-03	82	ACP2
67	11	56774260	58178587	1	1	5.4e-08	1.2e-06	4.7e-02	83	MED19
68	11	64721908	66333072	6	8	7.9e-13	4.8e-11	NaN	NaN	CTSW FIBP MAP3K11 SIPA1 SNX32
69	11	76673980	78578480	8	3	1.1e-08	7.4e-08	1.0e+00	100	C11orf67 INTS4 RP11-91P24.7
70	11	94199272	95663017	1	1	3.7e-10	3.2e-11	1.9e-02	88	SESN3
71	11	99859184	101559718	2	1	2.1e-36	4.8e-35	1.0e+00	100	ARHGAP42
72	11	106485489	107882823	1	1	8.2e-08	6.9e-10	4.1e-04	67	RP11-819C21.1
73	11	129575976	130992111	1	1	5.4e-16	3.5e-16	4.7e-02	94	ADAMTS8
74	12	49780778	51912062	7	1	1.9e-15	1.8e-15	1.0e+00	100	CERS5
75	12	52742148	54146451	1	1	3.8e-08	1.4e-08	1.1e-01	92	TENC1
76	12	89286081	90799212	2	2	6.6e-09	8.9e-16	1.1e-06	63	ATP2B1 LOC338758
77	12	109973273	113517494	22	12	7.0e-41	1.7e-54	NaN	NaN	ADAM1A ALDH2 BRAP ERP29 GPN3 NAA25 PPTC7 SH2B3 VPS29
78	12	120498862	120999127	1	1	2.2e-09	1.8e-06	5.0e-01	98	SIRT4
79	12	122625212	124715313	13	7	1.8e-14	5.9e-13	1.0e+00	100	ABCB9 MPHOSPH9 PITPNM2 RP11-282O18.3 SETD8
80	13	114259570	114762917	1	1	1.5e-07	5.6e-08	1.9e-02	81	FAM70B
81	14	22722491	24125886	1	1	7.4e-09	7.4e-07	2.0e-06	8	HAUS4
82	14	55273730	56741515	1	1	2.6e-07	1.9e-08	4.2e-03	74	KTN1-AS1
83	15	39530508	43198430	20	8	3.7e-14	8.9e-13	1.0e+00	100	CHP1 EHD4 EIF2AK4 EXD1 INO80 JMJD7-PLA2G4B RP11-23P13.4 RPAP1
84	15	48352252	49794848	1	1	1.3e-11	1.9e-08	2.8e-01	96	CEP152
85	15	70697945	72771648	1	1	3.2e-08	3.7e-09	3.7e-02	88	THSD4
86	15	73933444	76108550	13	1	3.1e-28	1.0e-27	7.3e-03	94	MPI
87	15	77888924	79802863	2	1	2.6e-12	5.5e-12	3.7e-02	91	ADAMTS7
88	15	80743350	81292020	1	1	2.9e-07	2.4e-10	1.7e-04	65	FAM108C1
89	15	90712555	92135418	3	2	4.0e-28	4.8e-24	9.3e-01	100	FES FURIN
90	16	1381714	2713729	1	1	7.8e-08	1.8e-08	8.3e-02	90	SLC9A3R2
91	16	3301360	4696654	1	1	2.8e-07	3.0e-08	2.7e-02	84	RP11-462G12.1
92	16	24614505	25167985	1	1	2.3e-07	2.5e-07	3.0e-01	96	SLC5A11
93	16	29850705	31860399	18	2	4.4e-13	4.0e-10	4.1e-01	98	C16orf93 PRSS53
94	16	55526487	57089130	1	1	1.8e-07	8.3e-07	1.5e-01	91	GNAO1
95	16	68523336	70063989	2	1	1.7e-09	4.6e-08	8.3e-02	90	SNTB2
96	16	81230341	84527021	2	2	1.1e-11	8.3e-13	5.9e-03	85	CDH13 CMIP
97	17	1508522	2923933	3	1	4.9e-11	1.6e-09	1.0e+00	100	SRR
98	17	3208350	5323989	4	2	7.2e-09	7.1e-10	3.0e-04	66	ANKFY1 ARRB2
99	17	6397773	8484683	12	3	1.5e-10	3.7e-10	1.0e+00	100	C17orf81 CYB5D1 EIF5A
100	17	14714000	16109675	1	1	2.6e-07	1.0e-07	3.4e-02	84	AC005517.3
101	17	42413481	43570226	5	1	1.6e-12	1.4e-11	2.7e-01	97	NMT1
102	17	46888301	48347817	2	1	8.2e-10	4.0e-10	2.0e-05	54	RP5-1029K10.2
103	17	56487887	57889985	1	1	2.9e-07	1.5e-07	5.9e-02	87	AC099850.1
104	17	76087754	77462467	1	1	5.8e-08	2.1e-08	1.0e+00	100	USP36
105	19	16914952	17430915	1	1	2.5e-07	3.3e-08	4.0e-02	86	HAUS8
106	19	21206463	22643745	1	1	2.1e-07	3.3e-06	9.3e-02	87	ZNF100
107	19	29606361	31013761	1	1	3.6e-19	6.3e-19	6.5e-02	96	CCNE1
108	20	9925555	11347455	1	1	4.9e-10	2.6e-22	2.5e-19	14	JAG1
109	20	18506005	20398583	1	1	4.0e-09	1.3e-09	1.1e-01	93	SLC24A3
110	20	29833609	31312916	2	1	1.3e-10	2.1e-07	2.6e-01	95	C20orf160
111	20	46551079	48140682	1	1	2.4e-09	3.2e-11	5.6e-13	-18	PREX1
112	20	56858751	58262841	4	2	5.6e-11	4.8e-18	3.7e-05	77	TH1L ZNF831
113	20	61522825	62912463	10	3	1.1e-10	1.5e-10	1.0e+00	100	GMEB2 LIME1 TCEA2
114	22	27445437	28889735	1	1	2.3e-07	1.1e-09	1.0e-03	71	MN1
115	22	40195017	41004384	2	1	3.2e-08	1.7e-08	2.0e-02	83	ADSL

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Systolic Blood Pressure	11.66	113	99	220.0	0.88	3.4e-43	AC099850.1 ACP2 ADAM1A ADAMTS8 ADM ADRB1 AGT ALDH2 ARHGAP42 ARNTL ATP2B1 BRAP C10orf118 C17orf81 C1GALT1 C1orf167 C20orf160 C4orf22 C4orf3 CACNB2 CCDC148 CDH13 CERS5 CHP1 CLCN6 CMIP CPEB4 CSTA CTSW CYB5D1 DCAF16 EDEM3 EHD4 EIF2AK4 ERAP2 ERP29 EVX1 EXD1 FAM108C1 FES FIBP FURIN GIMAP7 GLS GMEB2 GPN3 HAUS4 HAUS8 HYI IGFBP3 INO80 IPO11 IRAK1BP1 ITGB5 JMJD7-PLA2G4B KRT8P33 LIME1 LOC100129961 LOC338758 LSP1 MAP3K11 MED19 MPI MSTN MTHFR NAA25 NME6 NMT1 NOC3L NOV NRBF2 NSUN6 NT5C2 PDE1A PPP3CA PPTC7 REEP3 RERE RNF123 RP11-23P13.4 RP11-436D10.3 RP11-819C21.1 RP5-1029K10.2 RPAP1 RPL39P5 RSRC1 RYK SCMH1 SH2B3 SIPA1 SIRT4 SLC16A1 SLC24A3 SLC25A37 SLC5A11 SLC9A3R2 SNX32 SRR STAG3L1 STXBP5 SWAP70 TCEA2 TENC1 TH1L TMEM87B TNNI2 TNNT3 ULK4 USP36 VPS29 WNT2B ZNF100 ZNF831
Systolic blood pressure, automated reading	9.68	92	73	162.2	0.90	3.6e-38	AC099850.1 ACP2 ADAM1A ADAMTS8 ADM ADRB1 AGT ALDH2 ARHGAP42 ARNTL ATP2B1 BRAP C17orf81 C1orf167 C4orf22 CACNB2 CCDC148 CD164 CERS5 CHP1 CLCN6 CPEB4 CTSW DCAF16 DYNC1I2 EDEM3 EIF2AK4 ERP29 EVX1 EXD1 FAM108C1 FES FIBP FURIN GIMAP7 GMEB2 HAUS4 HAUS8 HYI IGFBP3 INO80 IPO11 IRAK1BP1 ITGB5 LIME1 LOC100129961 LOC338758 LSP1 MAP3K11 MED19 MPI MSRA MSTN MTHFR NAA25 NCF1 NEIL2 NME6 NMT1 NOC3L NOV NRBF2 NSUN6 NT5C2 PPTC7 RERE RNF123 RP11-23P13.4 RP11-436D10.3 RP11-819C21.1 RP5-1029K10.2 RSRC1 SCMH1 SH2B3 SIPA1 SLC16A1 SLC5A11 SLC9A3R2 SNX32 SRR STAG3L1 STXBP5 SWAP70 TCEA2 TH1L TMEM87B TNNI2 TNNT3 ULK4 USP36 WNT2B ZNF831
High blood pressure	8.83	82	55	122.2	0.97	1.6e-57	ABO ACP2 ADAM1A ADRB1 AGT ALDH2 ARHGAP42 ARNTL ATP2B1 BRAP C10orf118 C16orf93 C1GALT1 C1orf167 C20orf160 C4orf22 CACNB2 CCDC148 CCNE1 CERS5 CHP1 CLCN6 CMIP CTSW CYB5D1 DCAF16 EDEM3 ERP29 EVX1 EXD1 FAM108C1 FES FURIN GMEB2 HAUS8 INO80 IRAK1BP1 ITGB5 LIME1 LOC338758 LSP1 MANBA MLLT10 MPI MSRA MTHFR NAA25 NCF1 NEIL2 NME6 NMT1 NOC3L NRBF2 NSUN6 NT5C2 PDE1A PPTC7 PRSS53 REEP3 RERE RP11-261C10.5 RP11-436D10.3 RP5-1029K10.2 RPAP1 RSRC1 RYK SH2B3 SIPA1 SLC25A37 SLC5A11 SNX32 SRR STAG3 STAG3L1 SWAP70 TCEA2 TH1L TNNI2 TNNT3 WNT2B ZKSCAN1 ZNF831
Hypertension (Self-reported)	8.69	81	56	124.4	0.97	2.0e-55	ABO ACP2 ADAM1A ADM ADRB1 AGT ALDH2 ARHGAP42 ARNTL ATP2B1 BRAP C10orf118 C16orf93 C1GALT1 C1orf167 C20orf160 C4orf22 CACNB2 CCDC148 CCNE1 CERS5 CHP1 CLCN6 CMIP CTSW CYB5D1 DCAF16 EDEM3 ERP29 EVX1 EXD1 FAM108C1 FES FURIN GMEB2 HAUS8 INO80 IRAK1BP1 ITGB5 LIME1 LOC338758 LSP1 MANBA MAP3K11 MLLT10 MPI MSRA MTHFR NAA25 NCF1 NEIL2 NME6 NMT1 NOC3L NRBF2 NSUN6 NT5C2 PDE1A PPTC7 PRSS53 RERE RP11-261C10.5 RP11-436D10.3 RPAP1 RSRC1 SH2B3 SIPA1 SLC25A37 SLC5A11 SNX32 SRR STAG3 STAG3L1 SWAP70 TCEA2 TH1L TNNI2 TNNT3 WNT2B ZKSCAN1 ZNF831
Vascular/heart problems diagnosed by doctor	8.52	79	54	120.0	-0.97	2.5e-58	ABO ACP2 ADAM1A ADRB1 AGT ALDH2 ARHGAP42 ARNTL ATP2B1 BRAP C10orf118 C16orf93 C1GALT1 C1orf167 C20orf160 C4orf22 C8orf38 CACNB2 CCDC148 CERS5 CHP1 CLCN6 CMIP CTSW CYB5D1 DCAF16 EDEM3 ERP29 EVX1 EXD1 FAM108C1 FES FURIN GMEB2 HAUS8 HYI INO80 IRAK1BP1 ITGB5 LIME1 LMOD1 LOC338758 LSP1 MANBA MAP3K11 MLLT10 MPI MSRA MTHFR NAA25 NCF1 NEIL2 NME6 NOC3L NRBF2 NSUN6 NT5C2 PDE1A PRSS53 RERE RP11-261C10.5 RP11-436D10.3 RP5-1029K10.2 RPAP1 RSRC1 RYK SH2B3 SIPA1 SLC5A11 SNX32 STAG3L1 SWAP70 TCEA2 TH1L TNNI2 TNNT3 WNT2B ZKSCAN1 ZNF831
Cardiovascular Disease	8.44	83	58	128.9	0.97	8.0e-62	ACP2 ADAM1A ADRB1 AGT ALDH2 ANKFY1 ARHGAP42 ARNTL ATP2B1 BRAP C10orf118 C16orf93 C1GALT1 C1orf167 C20orf160 C4orf22 C8orf38 CACNB2 CCDC148 CERS5 CHP1 CLCN6 CMIP CPEB4 CTSW CYB5D1 DCAF16 EHD4 ERP29 EVX1 EXD1 FAM108C1 FES FURIN GIMAP7 GMEB2 HAUS8 INO80 IRAK1BP1 ITGB5 LIME1 LOC338758 LSP1 MANBA MAP3K11 MPHOSPH9 MPI MTHFR NAA25 NCF1 NME6 NMT1 NOC3L NRBF2 NSUN6 NT5C2 PDE1A PKHD1 PRSS53 RP11-23P13.4 RP11-261C10.5 RP11-436D10.3 RP11-462G12.1 RP11-819C21.1 RP5-1029K10.2 RPAP1 RYK SH2B3 SIPA1 SNX32 STAG3 STAG3L1 SWAP70 TCEA2 TH1L TNNI2 TNNT3 USP36 VPS29 WNT2B ZKSCAN1 ZNF100 ZNF831
Medication: Blood pressure	6.64	40	26	57.8	0.95	2.7e-24	ACP2 ADM ADRB1 AGT ALDH2 ARHGAP42 BRAP C1GALT1 C4orf22 CACNB2 CERS5 CHP1 CLCN6 CMIP CTSW CYB5D1 ERP29 EVX1 EXD1 FAM108C1 FES FURIN GMEB2 HAUS8 LIME1 LSP1 MAP3K11 MPI MSRA MTHFR NME6 NRBF2 NT5C2 RP11-436D10.3 SH2B3 SIPA1 TNNI2 TNNT3 WNT2B ZNF831
Medication: Blood pressure	5.88	32	18	40.0	0.97	4.7e-24	ACP2 ADAM1A ADRB1 ALDH2 ARHGAP42 ATP2B1 BRAP C1orf167 C20orf160 C4orf22 CLCN6 CMIP CTSW CYB5D1 DCAF16 ERP29 FAM108C1 FES FURIN LOC338758 LSP1 MANBA MPI MTHFR NME6 NOC3L SH2B3 TH1L TNNI2 TNNT3 WNT2B ZNF831
Blood Eosinophil Count	5.48	37	30	66.7	0.65	2.6e-06	ABCB9 ABO ACVR2A ADAM1A ADRA2B ALDH2 ARRB2 BRAP C16orf93 CD164 CERS5 CPEB4 CTSW EHD4 ERAP2 ERP29 FIBP GIGYF1 GIMAP7 GPN3 HAUS4 MAP3K11 MED19 MPHOSPH9 NAA25 PITPNM2 PPTC7 PRSS53 RERE RP11-282O18.3 RP5-1029K10.2 RPAP1 SH2B3 SIPA1 SNX32 VPS29 ZNF831
Pulse rate, automated reading	4.96	23	13	28.9	0.82	2.8e-07	ABO AC005517.3 ACHE ACP2 ADRA2B C16orf93 CASP7 CEP85L CSTA CTNNB1 GIGYF1 GPN3 KRT8P33 LINC00461 LMOD1 LOC100129961 MSTN PPTC7 RNF123 STAG3 STAG3L1 TRIP6 ZKSCAN1
Medication for cholesterol, blood pressure or diabetes	4.65	17	6	13.3	-0.96	1.3e-11	ARHGAP42 ATP2B1 C4orf22 CHP1 CLCN6 CTSW FAM108C1 FES FURIN LOC338758 MPI MTHFR NME6 RNF123 SH2B3 TH1L ZNF831
Medication: Bendroflumethiazide	4.64	19	8	17.8	0.94	4.4e-09	ACP2 ADAMTS7 ADRB1 AGT ARHGAP42 ATP2B1 C16orf93 CACNB2 CCNE1 EVX1 FES LSP1 MPI MSRA RP11-436D10.3 TNNI2 TNNT3 WNT2B ZNF831
Medication: Amlodipine	4.12	11	6	13.3	0.92	1.7e-06	ARHGAP42 C1orf167 CLCN6 FAM108C1 FES LSP1 MTHFR SIPA1 TNNI2 TNNT3 WNT2B
Medication for cholesterol	3.90	11	4	8.9	-0.95	9.9e-06	ALDH2 ARHGAP42 C4orf22 EVX1 FES HAUS8 LSP1 SH2B3 TNNT3 WNT2B ZNF831
High blood pressure (mother)	3.77	8	2	4.4	0.93	1.2e-04	AGT ARHGAP42 CLCN6 FES FURIN ITGB5 TNNT3 ZNF831
Hypothyroidism (self reported)	3.75	10	8	17.8	0.66	9.7e-03	ADAM1A ALDH2 BRAP ERP29 GIGYF1 NAA25 RERE SH2B3 SLC25A37 VPS29
High blood pressure (siblings)	3.71	8	3	6.7	0.97	3.6e-07	ACP2 ARHGAP42 CLCN6 FES NRBF2 PRSS53 SH2B3 TNNT3
Medication: Levothyroxine sodium	3.69	8	8	17.8	0.86	7.7e-04	ADAM1A ALDH2 BRAP ERP29 GIGYF1 NAA25 SH2B3 VPS29
Hypothyroidism/myxoedema (self-reported)	3.52	9	9	20.0	0.63	2.2e-02	ADAM1A ALDH2 BRAP ERP29 GIGYF1 MSRA NAA25 SH2B3 VPS29
Pulse rate	3.50	7	5	11.1	0.98	8.1e-07	AC005517.3 ACHE CEP85L CTNNB1 GIGYF1 STAG3 TRIP6
Number of self-reported non-cancer illnesses	3.35	13	3	6.7	0.95	6.4e-08	ALDH2 BRAP CCNE1 CLCN6 CYB5D1 ERP29 GMEB2 HAUS8 LIME1 MLLT10 RP5-1029K10.2 SH2B3 ZNF831
Medication: Atenolol	3.31	8	2	4.4	0.97	5.0e-05	ALDH2 ARHGAP42 BRAP CLCN6 ERP29 FES FURIN SH2B3
Blood White Count	3.26	41	28	62.2	0.62	8.9e-06	ABO ADAM1A ALDH2 ARHGAP42 ARRB2 BRAP C10orf118 C16orf93 C4orf3 CD164 CEP85L CERS5 CMIP CYB5D1 DCAF16 ERAP2 ERP29 FES FIBP FLNB FURIN GPN3 LIME1 LSP1 NAA25 NRBF2 NT5C2 PPTC7 PRSS53 REEP3 RERE RNF123 RP11-23P13.4 RP5-1029K10.2 SH2B3 SLC5A11 SLC9A3R2 SRR TMEM87B TNNI2 VPS29
Deep venous thrombosis (DVT) (self-reported)	3.15	1	1	2.2	0.00	1.0e+00	ABO
Number of treatments/medications taken	3.14	14	6	13.3	0.95	2.3e-07	ADAM1A ALDH2 ARHGAP42 C1GALT1 CHP1 DCAF16 EHD4 ERP29 FAM108C1 MANBA MLLT10 RNF123 SH2B3 ZNF831
Blood clot in the leg (DVT)	3.11	1	1	2.2	0.00	1.0e+00	ABO
Blood Platelet Count	3.10	48	42	93.3	0.16	2.4e-01	ABCB9 ADAM1A ADAMTS7 ALDH2 ANKFY1 C11orf67 C16orf93 C20orf160 C4orf3 CD164 CERS5 CLCN6 CTSW DCAF16 EDEM3 ERP29 FIBP FLNB GMEB2 GPN3 HAUS8 IPO11 IRAK1BP1 KRT8P33 LIME1 LINC00461 MPHOSPH9 MTHFR NAA25 NMT1 NOV NRBF2 PITPNM2 PPTC7 REEP3 RP11-282O18.3 RP11-436D10.3 RP11-462G12.1 RP11-91P24.7 RP5-1029K10.2 SETD8 SH2B3 SIPA1 SLC25A37 SNX32 STXBP5 TH1L VPS29
Lung FEV1/FVC ratio	3.07	30	18	40.0	0.19	3.2e-01	ABO ADM ADSL ANKFY1 ARHGAP42 ATP2B1 C16orf93 C1GALT1 CACNB2 CD164 CPEB4 CTNNB1 CYB5D1 EHD4 HAUS4 JMJD7-PLA2G4B KRT8P33 MLLT10 NRBF2 RERE RP11-23P13.4 RP11-436D10.3 RP5-1029K10.2 RPAP1 SLC24A3 STAG3 STEAP1 THSD4 ULK4 ZKSCAN1
Medication: Ramipril	3.01	4	1	2.2	1.00	1.8e-03	ADAM1A ARHGAP42 CMIP FES
Illnesses of siblings	3.00	5	1	2.2	-0.96	2.6e-03	CLCN6 FES PRSS53 SH2B3 SLC5A11
Leg fat percentage (left)	2.98	37	19	42.2	0.79	1.6e-09	ABCB9 ADM ARNTL C17orf81 C8orf38 CCDC148 CCNE1 CHP1 CLCN6 CTSW DCAF16 EDEM3 EXD1 FIBP GPN3 LIME1 LINC00461 LMOD1 LOC100129961 MLLT10 MPHOSPH9 MSRA NCF1 NMT1 PITPNM2 PPTC7 PRSS53 REEP3 RERE RNF123 RP11-462G12.1 RPAP1 SLC25A37 SLC5A11 SLC9A3R2 SNX32 STAG3L1
Medication: Lisinopril	2.95	5	0	0.0	0.96	9.7e-03	ARHGAP42 LSP1 NME6 NRBF2 ZNF831
Illnesses of father: High blood pressure	2.95	2	1	2.2	0.00	1.0e+00	C4orf22 FES
Leg fat mass (left)	2.94	35	24	53.3	0.76	3.9e-08	ADSL ARNTL C16orf93 C17orf81 C8orf38 CCNE1 CTSW DYNC1I2 EDEM3 EIF5A FAM108C1 FIBP GPN3 IFT57 LIME1 LINC00461 LMOD1 LOC100129961 MLLT10 MSRA NCF1 PITPNM2 PPTC7 PRSS53 RERE RNF123 RP11-462G12.1 SLC25A37 SLC5A11 SLC9A3R2 SNX32 STAG3L1 STXBP5 USP36 VPS29
Leg fat percentage (right)	2.93	37	20	44.4	0.83	7.4e-11	ABCB9 ADM ARNTL C17orf81 C8orf38 CCDC148 CCNE1 CHP1 CLCN6 CTSW DCAF16 EDEM3 EXD1 FIBP GPN3 LIME1 LINC00461 LMOD1 LOC100129961 MLLT10 MPHOSPH9 MSRA NCF1 NMT1 PITPNM2 PRSS53 REEP3 RERE RNF123 RP11-462G12.1 RPAP1 SLC25A37 SLC5A11 SLC9A3R2 SNX32 STAG3L1 STXBP5
Leg fat mass (right)	2.91	35	21	46.7	0.78	1.0e-08	ADSL ARNTL C16orf93 C17orf81 C8orf38 CCNE1 CTNNB1 CTSW DYNC1I2 EDEM3 EIF5A FIBP GPN3 IFT57 LIME1 LINC00461 LMOD1 LOC100129961 MLLT10 MSRA NCF1 PITPNM2 PPTC7 PRSS53 RERE RNF123 RP11-462G12.1 SLC25A37 SLC5A11 SLC9A3R2 SNX32 STAG3L1 STXBP5 USP36 VPS29
Birth weight of first child	2.88	12	7	15.6	-0.96	7.0e-10	ALDH2 BRAP C1orf167 CLCN6 DCAF16 ERP29 FES FURIN MTHFR SH2B3 SLC25A37 STAG3L1
Body mass index (BMI)	2.84	32	18	40.0	0.84	4.5e-10	ABCB9 ADSL ARNTL C16orf93 C17orf81 CCDC148 CCNE1 CTSW DYNC1I2 EDEM3 FIBP GPN3 IFT57 LINC00461 LMOD1 LOC100129961 MLLT10 MSRA NCF1 PITPNM2 PPTC7 PRSS53 REEP3 RERE RNF123 RP11-462G12.1 SLC25A37 SLC5A11 SLC9A3R2 SNX32 SRR STAG3L1
Blood Red Count	2.68	49	33	73.3	0.60	7.3e-07	ABCB9 ABO ACHE ACVR2A ADAM1A ADM ALDH2 ARNTL BRAP C20orf160 C4orf22 C8orf38 CCNE1 CD164 CLCN6 CPEB4 CYB5D1 ERP29 EXD1 GIGYF1 GMEB2 GPN3 HYI INO80 LIME1 LINC00461 LOC100129961 LSP1 MPI NAA25 NAT8 NME6 NT5C2 PKHD1 PPTC7 PRSS53 REEP3 RNF123 RP11-23P13.4 SETD8 SH2B3 SLC9A3R2 SNX32 TH1L TMEM87B ULK4 USP36 VPS29 ZNF100
Arm fat mass (right)	2.68	35	17	37.8	0.79	7.3e-09	ADSL ARNTL C16orf93 C17orf81 CCNE1 CLCN6 CTNNB1 CTSW DYNC1I2 EDEM3 EIF5A FIBP GPN3 IFT57 LIME1 LINC00461 LMOD1 LOC100129961 MLLT10 MSRA NCF1 PITPNM2 PPTC7 PRSS53 RERE RNF123 RP11-462G12.1 SLC25A37 SLC5A11 SLC9A3R2 SNX32 SRR STAG3L1 STXBP5 USP36
Waist circumference	2.67	26	16	35.6	0.92	3.6e-12	ADSL ARNTL C16orf93 C17orf81 CCDC148 CCNE1 CMIP CTNNB1 CTSW FAM108C1 FIBP IFT57 LIME1 LINC00461 LMOD1 MLLT10 NCF1 PRSS53 RNF123 RP11-462G12.1 SLC25A37 SLC5A11 SLC9A3R2 SNX32 STAG3L1 USP36
Whole body fat mass	2.66	34	23	51.1	0.79	8.2e-09	ANKFY1 ARNTL C16orf93 C17orf81 CCDC148 CCNE1 CTNNB1 CTSW DYNC1I2 EDEM3 EIF5A EVX1 FIBP GPN3 LIME1 LINC00461 LMOD1 LOC100129961 MLLT10 MSRA NCF1 PITPNM2 PPTC7 PRSS53 RERE RNF123 RP11-462G12.1 SLC25A37 SLC5A11 SLC9A3R2 SNX32 STAG3L1 STXBP5 USP36
Body fat percentage	2.65	34	18	40.0	0.79	1.5e-08	ABCB9 ABO ADM ARNTL C16orf93 C17orf81 CCDC148 CCNE1 CHP1 CLCN6 CTSW DCAF16 EDEM3 EVX1 EXD1 LIME1 LINC00461 LMOD1 LOC100129961 MLLT10 MSRA NCF1 NOC3L PITPNM2 PRSS53 RERE RNF123 RP11-462G12.1 RPAP1 SLC25A37 SLC5A11 SNX32 STAG3L1 STXBP5
Birth weight	2.64	12	10	22.2	-0.52	6.7e-02	ADAM1A ADRB1 ALDH2 BRAP C17orf81 DCAF16 ERP29 FES FURIN SH2B3 SRR TMEM87B
Arm fat mass (left)	2.62	33	19	42.2	0.84	4.4e-10	ADSL ARNTL C16orf93 C17orf81 CCNE1 CTNNB1 CTSW DYNC1I2 EIF5A FIBP GPN3 IFT57 LIME1 LINC00461 LMOD1 LOC100129961 MLLT10 MSRA NCF1 PITPNM2 PPTC7 PRSS53 RERE RNF123 RP11-462G12.1 SLC25A37 SLC5A11 SLC9A3R2 SNX32 SRR STAG3L1 STXBP5 USP36
BMI	2.61	43	26	57.8	0.71	4.9e-08	ABCB9 ADSL ANKFY1 ARNTL C16orf93 C17orf81 C20orf160 C4orf22 CCNE1 CHP1 CLCN6 CPEB4 CTNNB1 CTSW DYNC1I2 EDEM3 FAM108C1 FIBP GPN3 IFT57 LIME1 LINC00461 LMOD1 LOC100129961 MANBA MLLT10 NCF1 NRBF2 NT5C2 PITPNM2 PPTC7 PRSS53 REEP3 RNF123 RP11-462G12.1 SLC25A37 SLC5A11 SLC9A3R2 SNX32 SRR STAG3L1 STXBP5 USP36
Arm fat percentage (right)	2.60	34	23	51.1	0.79	1.0e-08	ABCB9 ABO ADM ARNTL C16orf93 C17orf81 CCDC148 CCNE1 CHP1 CLCN6 CTSW DCAF16 EDEM3 EVX1 EXD1 IFT57 LINC00461 LMOD1 LOC100129961 MLLT10 MSRA NCF1 PITPNM2 PRSS53 RERE RNF123 RP11-462G12.1 RPAP1 SLC25A37 SLC5A11 SNX32 SRR STAG3L1 STXBP5
Arm fat percentage (left)	2.58	32	23	51.1	0.84	8.0e-10	ABCB9 ABO ADM ARNTL C16orf93 C17orf81 CCDC148 CCNE1 CHP1 CTSW DCAF16 EDEM3 EVX1 EXD1 LINC00461 LMOD1 LOC100129961 MLLT10 MSRA NCF1 PITPNM2 PRSS53 RERE RNF123 RP11-462G12.1 RPAP1 SLC25A37 SLC5A11 SNX32 SRR STAG3L1 STXBP5
Arm predicted mass (left)	2.58	44	31	68.9	0.09	5.3e-01	ABO ADM ADSL ALDH2 BCKDHB BRAP C10orf118 C16orf93 CCNE1 CD164 CMIP CTNNB1 DCAF16 DYNC1I2 EIF5A ERP29 FAM108C1 FIBP GPN3 KRT8P33 LINC00461 LMOD1 MLLT10 MPHOSPH9 MSRA NMT1 NOV PDE1A PPTC7 PRSS53 RNF123 RP11-282O18.3 RP11-462G12.1 RPL39P5 SCMH1 SF3A3 SH2B3 SLC25A37 SLC5A11 SLC9A3R2 SNX32 STAG3L1 USP36 VPS29
Arm predicted mass (right)	2.57	44	34	75.6	0.07	6.6e-01	ABO ADM ADSL ALDH2 BCKDHB BRAP C10orf118 C16orf93 CCNE1 CD164 CMIP CTNNB1 DCAF16 DYNC1I2 EIF5A ERP29 FAM108C1 FIBP GPN3 KRT8P33 LINC00461 LMOD1 MLLT10 MPHOSPH9 MSRA NMT1 NOV PDE1A PPTC7 PRSS53 RNF123 RP11-282O18.3 RP11-462G12.1 SCMH1 SETD8 SF3A3 SH2B3 SLC25A37 SLC5A11 SLC9A3R2 SNX32 STAG3L1 USP36 VPS29
Arm fat-free mass (left)	2.57	46	31	68.9	0.08	5.8e-01	ABO ADM ADSL ALDH2 BCKDHB BRAP C10orf118 C16orf93 CCNE1 CD164 CTNNB1 CTSW DCAF16 DYNC1I2 EIF5A ERP29 FAM108C1 FIBP GPN3 KRT8P33 LIME1 LINC00461 LMOD1 MLLT10 MPHOSPH9 MSRA NMT1 NOV PDE1A PPTC7 PRSS53 RNF123 RP11-282O18.3 RP11-462G12.1 RPL39P5 SCMH1 SETD8 SF3A3 SH2B3 SLC25A37 SLC5A11 SLC9A3R2 SNX32 STAG3L1 USP36 VPS29
Father's age at death	2.56	4	2	4.4	-0.73	2.7e-01	ABO FES MPHOSPH9 SH2B3
Weight	2.55	41	29	64.4	0.49	9.0e-04	ADSL ALDH2 BCKDHB BRAP C10orf118 C16orf93 C17orf81 C8orf38 CCNE1 CD164 CTNNB1 CTSW DCAF16 DYNC1I2 EIF5A FAM108C1 FIBP GPN3 IFT57 KRT8P33 LIME1 LINC00461 LMOD1 MLLT10 MSRA NCF1 PPTC7 PRSS53 RNF123 RP11-282O18.3 RP11-436D10.3 RP11-462G12.1 SCMH1 SF3A3 SLC25A37 SLC5A11 SLC9A3R2 SNX32 STAG3L1 USP36 VPS29
Arm fat-free mass (right)	2.54	46	35	77.8	0.07	6.6e-01	ABO ADM ADSL ALDH2 BCKDHB BRAP C10orf118 C16orf93 CCNE1 CD164 CTNNB1 CTSW DCAF16 DYNC1I2 EIF5A ERP29 FAM108C1 FIBP GPN3 HAUS8 KRT8P33 LINC00461 LMOD1 MLLT10 MPHOSPH9 MSRA NMT1 NOV PDE1A PPTC7 PRSS53 RNF123 RP11-282O18.3 RP11-462G12.1 RPL39P5 SCMH1 SETD8 SF3A3 SH2B3 SLC25A37 SLC5A11 SLC9A3R2 SNX32 STAG3L1 USP36 VPS29
Hip circumference	2.53	35	23	51.1	0.24	1.5e-01	ALDH2 BRAP C16orf93 C17orf81 CCNE1 CLCN6 CPEB4 CTNNB1 DCAF16 DYNC1I2 EIF5A ERP29 FAM108C1 GPN3 IFT57 LIME1 LINC00461 LMOD1 LOC100129961 MLLT10 MSRA NCF1 PPTC7 PRSS53 RNF123 RP11-282O18.3 RP11-462G12.1 SH2B3 SLC25A37 SLC5A11 SLC9A3R2 SNX32 STAG3L1 USP36 VPS29
Illnesses of father: None of the above (group 1)	2.47	2	1	2.2	0.00	1.0e+00	FES SH2B3
Coronary Artery Disease (CAD)	2.46	4	2	4.4	0.34	6.6e-01	ABO ADAMTS7 ALDH2 BRAP
Trunk fat mass	2.46	31	21	46.7	0.77	2.6e-07	ARNTL C16orf93 C17orf81 C8orf38 CCNE1 CTNNB1 CTSW DYNC1I2 EDEM3 EIF5A EVX1 GPN3 LIME1 LINC00461 LMOD1 LOC100129961 MLLT10 MSRA NCF1 PITPNM2 PPTC7 PRSS53 RERE RNF123 RP11-462G12.1 SLC25A37 SLC5A11 SLC9A3R2 SNX32 STAG3L1 USP36
Basal metabolic rate	2.44	45	35	77.8	0.11	4.6e-01	ADM ADSL ALDH2 BCKDHB BRAP C10orf118 C16orf93 CCNE1 CD164 CPEB4 CTNNB1 CTSW DCAF16 DYNC1I2 EIF5A ERP29 FAM108C1 FIBP GPN3 KRT8P33 LINC00461 LMOD1 MLLT10 MPHOSPH9 MSRA NMT1 NOV PDE1A PPTC7 PRSS53 RNF123 RP11-282O18.3 RP11-436D10.3 RP11-462G12.1 SCMH1 SETD8 SF3A3 SH2B3 SLC25A37 SLC5A11 SLC9A3R2 SNX32 STAG3L1 USP36 VPS29
Allergy or Eczema	2.43	18	9	20.0	0.47	5.0e-02	ABCB9 ABO ADAM1A CHP1 CLCN6 EXD1 GMEB2 INO80 LIME1 MANBA MAP3K11 MPHOSPH9 MPI RERE RP11-282O18.3 RP5-1029K10.2 RPAP1 SRR
Type 2 Diabetes (T2D) (2018)	2.41	7	3	6.7	0.93	3.0e-04	ANKFY1 C1GALT1 CTSW MPHOSPH9 RNF123 SH2B3 SNX32
Trunk fat percentage	2.41	30	16	35.6	0.76	1.4e-06	ABO ADM ARNTL C16orf93 C17orf81 CCDC148 CCNE1 CHP1 CLCN6 CTNNB1 CTSW EDEM3 EVX1 LIME1 LINC00461 LMOD1 LOC100129961 MLLT10 NCF1 NOC3L PITPNM2 PRSS53 RERE RNF123 RP11-462G12.1 RPAP1 SLC25A37 SLC5A11 SNX32 STAG3L1
Whole body water mass	2.41	47	37	82.2	0.00	9.9e-01	ABCB9 ADM ADSL ALDH2 BCKDHB BRAP C10orf118 C16orf93 CCNE1 CD164 CTNNB1 DCAF16 DYNC1I2 EIF5A ERP29 FAM108C1 FIBP GPN3 HAUS8 KRT8P33 LINC00461 LMOD1 MPHOSPH9 MSRA NMT1 NOV NT5C2 PDE1A PPTC7 PRSS53 RNF123 RP11-282O18.3 RP11-436D10.3 RP11-462G12.1 RPL39P5 SCMH1 SETD8 SF3A3 SH2B3 SLC25A37 SLC5A11 SLC9A3R2 SNX32 STAG3L1 ULK4 USP36 VPS29
Whole body fat-free mass	2.40	47	35	77.8	0.01	9.7e-01	ABCB9 ADM ADSL ALDH2 BCKDHB BRAP C10orf118 C16orf93 CCNE1 CD164 CPEB4 CTNNB1 DCAF16 DYNC1I2 EIF5A ERP29 FAM108C1 FIBP GPN3 HAUS8 KRT8P33 LINC00461 LMOD1 MPHOSPH9 MSRA NMT1 NOV NT5C2 PDE1A PPTC7 PRSS53 RNF123 RP11-282O18.3 RP11-436D10.3 RP11-462G12.1 SCMH1 SETD8 SF3A3 SH2B3 SLC25A37 SLC5A11 SLC9A3R2 SNX32 STAG3L1 ULK4 USP36 VPS29
Trunk fat-free mass	2.39	42	34	75.6	-0.12	4.3e-01	ABCB9 ABO ADM ADSL ALDH2 BCKDHB BRAP C10orf118 C16orf93 CCNE1 CD164 CTNNB1 DCAF16 DYNC1I2 ERP29 FAM108C1 GPN3 HAUS8 KRT8P33 LMOD1 MN1 MPHOSPH9 NMT1 NOV PDE1A PPTC7 PRSS53 RNF123 RP11-282O18.3 RP11-436D10.3 RP11-462G12.1 RPL39P5 SCMH1 SETD8 SF3A3 SH2B3 SLC25A37 SLC5A11 SLC9A3R2 ULK4 USP36 VPS29
Trunk predicted mass	2.39	42	34	75.6	-0.13	4.1e-01	ABCB9 ABO ADM ADSL ALDH2 BCKDHB BRAP C10orf118 C16orf93 CCNE1 CD164 CTNNB1 DCAF16 DYNC1I2 ERP29 FAM108C1 GPN3 HAUS8 KRT8P33 LMOD1 MN1 MPHOSPH9 NMT1 NOV PDE1A PPTC7 PRSS53 RNF123 RP11-282O18.3 RP11-436D10.3 RP11-462G12.1 RPL39P5 SCMH1 SETD8 SF3A3 SH2B3 SLC25A37 SLC5A11 SLC9A3R2 ULK4 USP36 VPS29
Medication: Cholesterol lowering	2.37	6	1	2.2	0.54	2.7e-01	ABO ARHGAP42 CHP1 CLCN6 FES ZNF831
Heel T-Score	2.35	52	38	84.4	0.15	2.7e-01	ABCB9 ABO ACHE ACP2 ADRA2B ADSL ANKFY1 ARHGAP42 C11orf67 C16orf93 C17orf81 C20orf160 CASP7 CD164 CMIP CPEB4 CTNNB1 CTSW CYB5D1 DCAF16 EVX1 FLNB GIGYF1 GLS JAG1 KRT8P33 LOC338758 MAP3K11 MPHOSPH9 NMT1 NT5C2 PDE1A PITPNM2 PRSS53 RERE RNF123 RP11-282O18.3 RP11-462G12.1 SCMH1 SETD8 SF3A3 SIPA1 SLC5A11 SLC9A3R2 SNTB2 SNX32 SRR TH1L THSD4 TMEM87B TRIP6 WNT2B
Leg fat-free mass (right)	2.33	43	30	66.7	0.14	3.8e-01	ADM ADSL ALDH2 BCKDHB C10orf118 C16orf93 CCNE1 CD164 CPEB4 CTNNB1 DCAF16 DYNC1I2 FAM108C1 FES FURIN GPN3 HAUS8 KRT8P33 LINC00461 LMOD1 MPHOSPH9 MSRA NMT1 NOV NT5C2 PDE1A PPTC7 PRSS53 RNF123 RP11-282O18.3 RP11-436D10.3 RP11-462G12.1 SCMH1 SETD8 SF3A3 SLC25A37 SLC5A11 SLC9A3R2 SNX32 STAG3L1 ULK4 USP36 VPS29
Leg predicted mass (right)	2.33	43	30	66.7	0.14	3.8e-01	ADM ADSL ALDH2 BCKDHB C10orf118 C16orf93 CCNE1 CD164 CPEB4 CTNNB1 DCAF16 DYNC1I2 FAM108C1 FES FURIN GPN3 HAUS8 KRT8P33 LINC00461 LMOD1 MPHOSPH9 MSRA NMT1 NOV NT5C2 PDE1A PPTC7 PRSS53 RNF123 RP11-282O18.3 RP11-436D10.3 RP11-462G12.1 SCMH1 SETD8 SF3A3 SLC25A37 SLC5A11 SLC9A3R2 SNX32 STAG3L1 ULK4 USP36 VPS29
Leg fat-free mass (left)	2.32	41	29	64.4	0.23	1.6e-01	ADM ADSL ALDH2 BCKDHB C10orf118 C16orf93 CCNE1 CD164 CPEB4 CTNNB1 DCAF16 DYNC1I2 FAM108C1 FURIN GPN3 KRT8P33 LINC00461 LMOD1 MLLT10 MPHOSPH9 MSRA NMT1 NOV NT5C2 PDE1A PPTC7 PRSS53 RNF123 RP11-282O18.3 RP11-436D10.3 RP11-462G12.1 SCMH1 SF3A3 SLC25A37 SLC5A11 SLC9A3R2 SNX32 STAG3L1 ULK4 USP36 VPS29
Leg predicted mass (left)	2.32	41	27	60.0	0.23	1.5e-01	ADM ADSL ALDH2 BCKDHB C10orf118 C16orf93 CCNE1 CD164 CPEB4 CTNNB1 DCAF16 DYNC1I2 FAM108C1 FURIN GPN3 KRT8P33 LINC00461 LMOD1 MLLT10 MPHOSPH9 MSRA NMT1 NOV NT5C2 PDE1A PPTC7 PRSS53 RNF123 RP11-282O18.3 RP11-436D10.3 RP11-462G12.1 SCMH1 SF3A3 SLC25A37 SLC5A11 SLC9A3R2 SNX32 STAG3L1 ULK4 USP36 VPS29
Illnesses of father: Heart disease	2.28	4	3	6.7	0.98	1.7e-02	ABO ADAMTS7 CDH13 FES
Illnesses of mother	2.26	1	1	2.2	0.00	1.0e+00	FES
Allergy	2.24	14	8	17.8	-0.62	1.7e-02	ABCB9 ABO CHP1 EXD1 FES GMEB2 INO80 LIME1 MANBA MPHOSPH9 RERE RP11-282O18.3 RP5-1029K10.2 SETD8
Overall health rating	2.24	12	8	17.8	0.97	8.0e-09	C11orf67 CCNE1 CTSW LMOD1 MLLT10 MSRA NCF1 PRSS53 RNF123 RP11-261C10.5 SLC5A11 SNX32
Medication: Simvastatin	2.21	3	1	2.2	0.00	1.0e+00	ABO FES ZNF831
Medication: Aspirin	2.20	1	1	2.2	0.00	1.0e+00	FES
Qualifications: A levels/AS levels or equivalent	2.18	10	6	13.3	-0.95	2.5e-06	ABCB9 DCAF16 MPHOSPH9 MSRA RNF123 RP11-261C10.5 RP11-282O18.3 SETD8 SLC5A11 STAG3L1
Medication: Aspirin	2.17	1	1	2.2	0.00	1.0e+00	FES
Hayfever, allergic rhinitis or eczema	2.14	10	5	11.1	0.81	4.5e-03	ABCB9 ADAM1A CHP1 EXD1 INO80 LIME1 MPHOSPH9 PITPNM2 RERE RP11-282O18.3
Sitting height	2.14	34	23	51.1	-0.23	1.8e-01	ABCB9 ADM ADRB1 AGPAT2 BCKDHB C10orf118 C20orf160 CCNE1 CD164 CERS5 CHP1 CTNNB1 DCAF16 EXD1 FAM108C1 FLNB IGFBP3 JAG1 KRT8P33 MN1 MPHOSPH9 NMT1 NOV PITPNM2 RP11-282O18.3 RP11-436D10.3 RP5-1029K10.2 RPL39P5 RSRC1 SCMH1 SETD8 SF3A3 SLC9A3R2 ZNF831
Breast Cancer	2.13	9	5	11.1	0.20	6.1e-01	ADSL CPEB4 FES FIBP FURIN MLLT10 RP11-436D10.3 SNX32 TNNT3
Impedance of arm (right)	2.13	29	16	35.6	-0.38	3.3e-02	ABO ADAMTS8 ADM ADSL CERS5 CMIP CTSW EVX1 FIBP GPN3 HAUS8 KTN1-AS1 LMOD1 LSP1 MANBA MLLT10 MSRA NOC3L NRBF2 PDE1A PPTC7 PRSS53 RNF123 RP11-462G12.1 RP5-1029K10.2 SLC9A3R2 SNX32 STAG3L1 VPS29
Impedance of arm (left)	2.13	32	17	37.8	-0.35	4.2e-02	ABO ADAMTS8 ADM ADSL ALDH2 CERS5 CMIP CTSW EVX1 FAM108C1 FIBP GPN3 KTN1-AS1 LMOD1 LSP1 MANBA MLLT10 MSRA NOC3L NRBF2 PDE1A PPTC7 PRSS53 RNF123 RP11-462G12.1 RP5-1029K10.2 SH2B3 SLC9A3R2 SNX32 STAG3L1 TNNT3 VPS29
Schizophrenia (2018)	2.11	6	4	8.9	-0.36	4.9e-01	ABCB9 FES FURIN NT5C2 RP11-261C10.5 U91328.21
Schizophrenia (2014)	2.08	13	4	8.9	-0.12	6.7e-01	ABCB9 CERS5 DYNC1I2 FES FURIN GIGYF1 MPHOSPH9 MSRA NT5C2 RERE RP11-261C10.5 RP11-282O18.3 SETD8
Impedance of whole body	2.08	32	23	51.1	-0.27	1.2e-01	ABO ADAMTS8 ADM ADSL C4orf3 CCNE1 CERS5 CTSW FAM108C1 FIBP GNAO1 HAUS8 KRT8P33 KTN1-AS1 LINC00461 LMOD1 MANBA MSRA NCF1 NMT1 NOC3L NT5C2 PDE1A PRSS53 RNF123 RP11-23P13.4 RP11-462G12.1 RP5-1029K10.2 SNX32 STAG3L1 SWAP70 VPS29
Impedance of leg (right)	2.06	37	26	57.8	-0.18	2.7e-01	ADM ADRA2B ADSL ARHGAP42 C16orf93 C4orf3 CCNE1 CERS5 CTSW FAM108C1 FES FIBP FURIN GIMAP7 GNAO1 HAUS8 IGFBP3 JMJD7-PLA2G4B KRT8P33 LINC00461 LMOD1 MSRA NCF1 NMT1 NOC3L NT5C2 PRSS53 RNF123 RP11-23P13.4 RP11-462G12.1 RP5-1029K10.2 SNX32 SRR STAG3L1 SWAP70 TH1L ULK4
Height	2.03	71	56	124.4	-0.29	1.2e-02	ABCB9 ABO ACHE ACP2 ADM ADRB1 AGPAT2 ALDH2 ARHGAP42 BCKDHB BRAP C11orf67 C16orf93 CCNE1 CD164 CEP152 CERS5 CHP1 CTNNB1 CTSW DCAF16 DYNC1I2 EDEM3 EIF5A ERP29 EVX1 EXD1 FES FURIN GIGYF1 GIMAP7 HYI INO80 JAG1 KRT8P33 KTN1-AS1 LSP1 MED19 MN1 MPHOSPH9 MSTN NMT1 NOV PDE1A PITPNM2 PPTC7 REEP3 RNF123 RP11-282O18.3 RP11-436D10.3 RP11-462G12.1 RP11-91P24.7 RP5-1029K10.2 RPAP1 RPL39P5 RSRC1 RYK SCMH1 SETD8 SF3A3 SH2B3 SLC24A3 SLC25A37 SLC5A11 SLC9A3R2 SNX32 TNNT3 TRIP6 USP36 WNT2B ZNF831
Heart attack/myocardial infarction (self-reported)	2.03	2	1	2.2	0.00	1.0e+00	FES SH2B3
Bipolar Disorder or Schizophrenia	2.02	12	4	8.9	0.09	7.8e-01	C1orf167 CERS5 FES FURIN GIGYF1 MSRA NAT8 NT5C2 RP11-261C10.5 RP11-282O18.3 SETD8 U91328.21
Impedance of leg (left)	2.01	35	25	55.6	-0.18	2.7e-01	ADM ADRA2B ADSL ARHGAP42 C16orf93 C4orf3 CCNE1 CERS5 CTSW FAM108C1 FES FIBP FURIN GIMAP7 GNAO1 HAUS8 IGFBP3 JMJD7-PLA2G4B KRT8P33 LINC00461 LMOD1 MSRA NMT1 NOC3L NT5C2 PRSS53 RNF123 RP11-23P13.4 RP11-462G12.1 RP5-1029K10.2 SNX32 SRR STAG3L1 SWAP70 ULK4
Heart attack	1.99	1	1	2.2	0.00	1.0e+00	FES
Diabetes diagnosed by doctor	1.98	3	0	0.0	0.00	1.0e+00	CTSW MPHOSPH9 RNF123
High cholesterol (Self-reported)	1.98	4	1	2.2	0.59	4.1e-01	ABO ARHGAP42 DCAF16 MPHOSPH9
Pulse wave Arterial Stiffness index	1.97	1	1	2.2	0.00	1.0e+00	ADAM1A
Medication for pain relief, constipation, heartburn	1.97	5	2	4.4	-0.94	1.9e-02	C20orf160 FAM108C1 MPHOSPH9 RP11-261C10.5 U91328.21
Irritable Bowel Disease (IBD)	1.96	10	4	8.9	0.66	3.9e-02	AGPAT2 ERAP2 GIGYF1 GMEB2 LIME1 LSP1 RNF123 RP11-436D10.3 TNNI2 TRIP6
Standing height	1.96	53	35	77.8	-0.28	3.7e-02	ABCB9 ACHE ACP2 ACVR2A ADM ADRB1 AGPAT2 ALDH2 BCKDHB BRAP C10orf118 C11orf67 CCNE1 CD164 CEP152 CERS5 CHP1 CTNNB1 CTSW DCAF16 DYNC1I2 EDEM3 EXD1 INO80 JAG1 KRT8P33 MN1 MPHOSPH9 MSRA NMT1 NOV PDE1A PITPNM2 REEP3 RP11-282O18.3 RP11-436D10.3 RP11-462G12.1 RP11-91P24.7 RP5-1029K10.2 RPL39P5 RYK SCMH1 SETD8 SF3A3 SH2B3 SLC25A37 SLC5A11 SLC9A3R2 SNX32 TRIP6 USP36 WNT2B ZNF831
Qualifications: College or University degree	1.96	16	9	20.0	-0.85	6.6e-06	ABCB9 CCDC148 DCAF16 EDEM3 HAUS4 LIME1 LINC00461 LMOD1 MLLT10 MPHOSPH9 RNF123 RP11-261C10.5 RP11-282O18.3 SETD8 SLC5A11 SNX32
Long-standing illness, disability or infirmity	1.95	1	0	0.0	0.00	1.0e+00	CHP1
Fed-up feelings	1.92	10	3	6.7	-0.43	2.2e-01	ALDH2 ARNTL BRAP ERP29 LINC00461 MPHOSPH9 MSRA RNF123 SH2B3 SLC5A11
Comparative height size at age 10	1.92	22	16	35.6	-0.51	1.0e-02	ABCB9 ALDH2 BCKDHB BRAP CEP152 CTNNB1 DCAF16 ERP29 FAM108C1 IGFBP3 MN1 MPHOSPH9 NOV RP11-282O18.3 RP11-462G12.1 SCMH1 SETD8 SH2B3 SLC25A37 SLC9A3R2 U91328.21 USP36
Cholesterol lowering medication	1.92	3	1	2.2	0.00	1.0e+00	ABO DCAF16 PRSS53
Crohns Disease (2017)	1.90	6	4	8.9	0.48	3.4e-01	AGPAT2 ERAP2 LIME1 RNF123 RP11-436D10.3 SNX32
Medication: Atorvastatin	1.89	1	0	0.0	0.00	1.0e+00	ABO
Waist Hip Ratio (WHR)	1.88	22	15	33.3	0.41	4.7e-02	ABCB9 ADAM1A ADAMTS8 ADM ANKFY1 BCKDHB CMIP CPEB4 CTSW DYNC1I2 EHD4 EIF5A HAUS8 JMJD7-PLA2G4B MAP3K11 MPHOSPH9 RP11-23P13.4 RP11-282O18.3 SETD8 SIPA1 SWAP70 TCEA2
Taking other prescription medications	1.88	5	2	4.4	0.98	4.4e-03	ADAM1A ALDH2 ERP29 RNF123 SH2B3
Heel bone mineral density (BMD) T-score, automated (left)	1.88	8	5	11.1	0.39	3.4e-01	CMIP CYB5D1 JAG1 MAP3K11 MSRA RERE RNF123 SIPA1
Reaction Time	1.87	6	4	8.9	0.99	2.4e-04	ADAM1A ALDH2 BRAP ERP29 NAA25 SH2B3
Heel bone mineral density (BMD) T-score, automated (right)	1.87	9	5	11.1	0.40	2.9e-01	ACP2 CYB5D1 DCAF16 MAP3K11 MSRA RERE RNF123 SIPA1 WNT2B
Forced expiratory volume in 1-second (FEV1)	1.87	20	11	24.4	-0.17	4.6e-01	ARHGAP42 BCKDHB C11orf67 C1GALT1 CD164 CTNNB1 DCAF16 FLNB JAG1 LIME1 LOC100129961 MN1 MSRA NRBF2 PRSS53 RSRC1 SCMH1 THSD4 U91328.21 ULK4
Angina	1.85	3	3	6.7	0.00	1.0e+00	ADAMTS7 FES FURIN
Heart disease (mother)	1.85	1	0	0.0	0.00	1.0e+00	ALDH2
Schizophrenia vs Biploar Disorder	1.84	2	0	0.0	0.00	1.0e+00	GPN3 PPTC7
Body Mass Index (BMI) (2010)	1.84	1	0	0.0	0.00	1.0e+00	STAG3L1
Forced expiratory volume in 1-second (FEV1), Best measure	1.84	17	9	20.0	-0.12	6.4e-01	ABO BCKDHB C1GALT1 CTNNB1 DCAF16 FLNB JAG1 KRT8P33 LIME1 LOC100129961 MN1 NRBF2 PRSS53 RSRC1 SCMH1 THSD4 U91328.21
Angina (self-reported)	1.84	3	2	4.4	0.00	1.0e+00	ADAMTS7 FES FURIN
Mean time to correctly identify matches	1.84	6	5	11.1	0.98	3.7e-04	ADAM1A ALDH2 BRAP ERP29 NAA25 SH2B3
Age when periods started (menarche)	1.83	11	5	11.1	-0.99	2.2e-11	ARNTL CTSW EXD1 FIBP INO80 LSP1 NCF1 SNX32 STAG3L1 STXBP5 TNNI2
Forced vital capacity (FVC)	1.83	18	11	24.4	-0.09	7.3e-01	ACHE BCKDHB C11orf67 CTNNB1 DCAF16 FLNB GMEB2 JAG1 LIME1 LOC100129961 MLLT10 MN1 NOV RP11-91P24.7 RSRC1 SCMH1 TRIP6 U91328.21
Pulse wave peak to peak time	1.83	1	1	2.2	0.00	1.0e+00	ADAM1A
Smoking status: Previous	1.83	5	1	2.2	0.97	4.8e-03	ADAM1A ALDH2 BRAP ERP29 SH2B3
Medication: Metformin	1.82	2	0	0.0	0.00	1.0e+00	MANBA MPHOSPH9
Heart disease (siblings)	1.82	1	0	0.0	0.00	1.0e+00	FES
Crohns Disease (2012)	1.80	4	3	6.7	0.51	4.9e-01	ERAP2 LIME1 RNF123 RP11-436D10.3
Qualifications: nursing, teaching	1.80	5	2	4.4	-1.00	3.4e-04	LMOD1 MPHOSPH9 PKHD1 RNF123 RP11-282O18.3
Headache pain in last month	1.77	6	2	4.4	-0.29	5.7e-01	ALDH2 BRAP MED19 RP11-261C10.5 SLC24A3 U91328.21
LDL Cholesterol	1.76	5	4	8.9	-0.94	1.6e-02	ABO ALDH2 BRAP ERP29 SH2B3
Diabetes (self-reported)	1.76	3	1	2.2	0.00	1.0e+00	C1GALT1 MPHOSPH9 RNF123
Comparative body size at age 10	1.75	12	4	8.9	0.30	3.4e-01	ADRA2B ADSL C16orf93 CERS5 CTSW MAP3K11 MSRA NME6 RP11-462G12.1 SIPA1 SRR U91328.21
Qualifications: NVQ or HND or HNC or equivalent	1.75	2	0	0.0	0.00	1.0e+00	JMJD7-PLA2G4B RNF123
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.75	6	3	6.7	0.33	5.3e-01	JAG1 LIME1 NRBF2 PRSS53 THSD4 U91328.21
Depressed Affect (Nagel 2018)	1.74	8	4	8.9	-0.28	5.1e-01	ACP2 ARNTL LINC00461 MPHOSPH9 PPTC7 RERE RNF123 RP11-261C10.5
Age at First Birth	1.74	1	1	2.2	0.00	1.0e+00	RNF123
Past tobacco smoking	1.74	7	1	2.2	-0.78	2.1e-02	ADAM1A ALDH2 BRAP ERP29 MLLT10 SH2B3 SRR
Forced vital capacity (FVC), Best measure	1.74	19	9	20.0	-0.22	3.6e-01	ACHE ACP2 BCKDHB C11orf67 CTNNB1 DCAF16 FLNB GMEB2 JAG1 LIME1 LOC100129961 MLLT10 MN1 NOV PRSS53 RSRC1 SCMH1 TRIP6 U91328.21
Hand grip strength (right)	1.73	12	4	8.9	-0.12	6.9e-01	ACHE C11orf67 DCAF16 JAG1 LOC100129961 MLLT10 NMT1 SCMH1 SLC5A11 SLC9A3R2 TRIP6 WNT2B
HDL Cholesterol	1.72	5	1	2.2	-0.48	4.1e-01	ACP2 ADRB1 CTSW SIPA1 SNX32
Qualifications: None of the above	1.72	7	6	13.3	0.99	4.2e-07	ABCB9 IRAK1BP1 MPHOSPH9 RNF123 RP11-282O18.3 SETD8 SLC5A11
Medication: Paracetamol	1.72	3	2	4.4	0.00	1.0e+00	MLLT10 RP11-261C10.5 U91328.21
Average weekly red wine intake	1.72	4	1	2.2	-0.95	5.0e-02	ABCB9 MPI RP11-282O18.3 SETD8
Ever smoked	1.71	1	1	2.2	0.00	1.0e+00	SRR
Ulcerative Colitis (UC)	1.66	4	3	6.7	-0.87	1.3e-01	LIME1 LSP1 RNF123 TNNI2
Had menopause	1.66	3	0	0.0	0.00	1.0e+00	CHP1 EXD1 INO80
Age at first live birth	1.66	2	1	2.2	0.00	1.0e+00	DCAF16 RNF123
Miserableness	1.66	5	2	4.4	-0.34	5.8e-01	ACP2 MSRA RERE RNF123 RP11-261C10.5
Primary Biliary Cirrhosis	1.65	4	1	2.2	0.73	2.7e-01	ALDH2 ERP29 MANBA SH2B3
Verbal and Numeric Reasoning (VNR)	1.64	9	4	8.9	-0.81	7.6e-03	ABCB9 DCAF16 IRAK1BP1 LINC00461 MPHOSPH9 NAT8 RNF123 SLC5A11 U91328.21
Neuroticism score	1.64	7	3	6.7	-0.62	1.4e-01	ADM ARNTL CASP7 LINC00461 MPHOSPH9 MSRA RERE
Qualifications: O levels/GCSEs or equivalent	1.64	5	3	6.7	-0.98	2.7e-03	ABCB9 MPHOSPH9 RNF123 RP11-282O18.3 SETD8
Smoking status: Current	1.64	1	0	0.0	0.00	1.0e+00	MSRA
Pain experienced in last month	1.64	2	0	0.0	0.00	1.0e+00	ALDH2 RNF123
Current tobacco smoking	1.63	2	0	0.0	0.00	1.0e+00	MSRA SLC5A11
Peak expiratory flow (PEF)	1.63	7	5	11.1	0.06	8.9e-01	ABO C1GALT1 DCAF16 FLNB MSRA SLC9A3R2 THSD4
Mood swings	1.63	5	2	4.4	0.52	3.7e-01	ACP2 C11orf67 MSRA RNF123 SLC5A11
Supplements: Glucosamine	1.62	2	1	2.2	0.00	1.0e+00	NRBF2 REEP3
Wheeze or whistling in the chest in last year	1.61	4	2	4.4	0.98	1.6e-02	GMEB2 LIME1 RERE RNF123
Prostate Cancer	1.59	1	0	0.0	0.00	1.0e+00	LIME1
Ulcerative Colitis	1.59	4	2	4.4	-0.70	3.0e-01	LIME1 LSP1 RNF123 TNNI2
Hand grip strength (left)	1.59	7	4	8.9	-0.13	7.9e-01	ADSL DCAF16 JAG1 LOC100129961 SLC5A11 SLC9A3R2 WNT2B
Maternal smoking around birth	1.59	4	1	2.2	0.99	5.6e-03	C20orf160 MLLT10 RNF123 SLC5A11
Asthma (self-reported)	1.58	4	1	2.2	0.64	3.6e-01	LIME1 RERE RP5-1029K10.2 U91328.21
Asthma	1.57	4	1	2.2	0.62	3.8e-01	LIME1 RERE RP5-1029K10.2 U91328.21
Neuroticism (2016)	1.56	4	1	2.2	-0.57	4.3e-01	ADM LINC00461 MSRA RP11-462G12.1
Medication: Paracetamol	1.56	3	0	0.0	0.00	1.0e+00	MLLT10 RP11-261C10.5 U91328.21
Fluid intelligence score	1.55	7	2	4.4	-0.98	1.4e-04	DCAF16 LMOD1 MPHOSPH9 RNF123 RP11-282O18.3 SETD8 U91328.21
Hair/balding pattern: Pattern 3	1.55	1	1	2.2	0.00	1.0e+00	C4orf22
Hair/balding pattern: Pattern 4	1.55	4	3	6.7	0.48	5.2e-01	C4orf22 CERS5 CTNNB1 SRR
Intelligence (Savage-Jansen 2018)	1.54	13	6	13.3	-0.71	6.3e-03	ABCB9 CTNNB1 DCAF16 ERAP2 IRAK1BP1 LINC00461 LMOD1 MPHOSPH9 NAT8 RNF123 RP11-282O18.3 SETD8 SLC5A11
Pack years of smoking	1.54	2	1	2.2	0.00	1.0e+00	ADAMTS7 PPTC7
Lung FVC	1.53	19	12	26.7	-0.09	7.1e-01	ABCB9 ANKFY1 C1GALT1 CHP1 DCAF16 EXD1 GMEB2 INO80 JAG1 LIME1 LOC100129961 MLLT10 MPHOSPH9 NRBF2 PRSS53 RP11-282O18.3 RSRC1 SETD8 THSD4
Alcohol intake versus 10 years previously	1.53	1	1	2.2	0.00	1.0e+00	RNF123
Alcohol intake frequency.	1.53	7	3	6.7	0.99	5.5e-06	ABCB9 C16orf93 MPHOSPH9 PRSS53 RNF123 RP11-282O18.3 SETD8
Medication: Ibuprofen (e.g. Nurofen)	1.52	1	0	0.0	0.00	1.0e+00	U91328.21
Respiratory disease	1.51	6	3	6.7	0.99	1.9e-04	CHP1 GMEB2 LIME1 NMT1 RERE RP5-1029K10.2
Pack years adult smoking proportion	1.51	1	1	2.2	0.00	1.0e+00	ADAMTS7
Mineral and other dietary supplements	1.51	3	0	0.0	0.00	1.0e+00	NMT1 NRBF2 REEP3
Gout (self-reported)	1.50	2	0	0.0	0.00	1.0e+00	SH2B3 SIPA1
Forced expiratory volume in 1-second (FEV1), predicted	1.50	2	1	2.2	0.00	1.0e+00	DCAF16 DYNC1I2
Alzheimer’s Disease (including proxy)	1.49	4	3	6.7	-1.00	3.7e-03	C16orf93 PRSS53 STAG3 ZKSCAN1
Depression (Nagel 2018)	1.48	1	0	0.0	0.00	1.0e+00	RERE
Worrier / anxious feelings	1.48	3	1	2.2	0.00	1.0e+00	ARNTL MSRA RP11-462G12.1
Pulse wave reflection index	1.48	1	0	0.0	0.00	1.0e+00	ADAMTS8
Frequency of tiredness / lethargy in last 2 weeks	1.47	3	0	0.0	0.00	1.0e+00	BRAP LMOD1 RERE
Age at last live birth	1.47	1	1	2.2	0.00	1.0e+00	RNF123
Sensitivity / hurt feelings	1.46	4	2	4.4	-0.96	3.9e-02	AC099850.1 FES FURIN MSRA
Worry too long after embarrassment	1.46	2	2	4.4	0.00	1.0e+00	ARNTL MSRA
Knee pain experienced in last month	1.46	2	0	0.0	0.00	1.0e+00	PRSS53 RP11-261C10.5
Smoking Status	1.44	9	3	6.7	0.22	5.7e-01	ADAM1A CPEB4 CTSW FES MLLT10 RERE SLC5A11 SNX32 SRR
Number of operations (self-reported)	1.43	1	0	0.0	0.00	1.0e+00	MLLT10
Mouth/teeth dental problems	1.42	2	0	0.0	0.00	1.0e+00	NCF1 RP11-261C10.5
Neuroticism (Nagel 2018)	1.41	6	3	6.7	-0.47	3.5e-01	ACP2 ADM ARNTL FURIN LINC00461 RERE
Fasting Glucose	1.41	1	1	2.2	0.00	1.0e+00	ACP2
Mouth/teeth dental problems: Dentures	1.41	2	0	0.0	0.00	1.0e+00	MSRA RNF123
Medication: Allopurinol	1.41	1	0	0.0	0.00	1.0e+00	CYB5D1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.40	1	0	0.0	0.00	1.0e+00	U91328.21
Migraine (self-reported)	1.40	2	0	0.0	0.00	1.0e+00	NT5C2 SLC24A3
Leg pain on walking	1.40	1	1	2.2	0.00	1.0e+00	RNF123
Risk taking	1.40	2	0	0.0	0.00	1.0e+00	MSRA RP11-261C10.5
Neuroticism	1.39	7	2	4.4	-0.56	1.9e-01	ADM ARNTL CASP7 DYNC1I2 FURIN LINC00461 RERE
Tense / 'highly strung'	1.39	3	1	2.2	0.00	1.0e+00	MSRA NT5C2 RERE
Bilateral oophorectomy (both ovaries removed)	1.38	1	0	0.0	0.00	1.0e+00	MLLT10
Health satisfaction	1.38	1	0	0.0	0.00	1.0e+00	LMOD1
Irritability	1.38	2	2	4.4	0.00	1.0e+00	LINC00461 MSRA
Lung cancer (father)	1.36	1	0	0.0	0.00	1.0e+00	ADAMTS7
Guilty feelings	1.36	2	0	0.0	0.00	1.0e+00	ARNTL MSRA
Ever had hysterectomy (womb removed)	1.35	1	0	0.0	0.00	1.0e+00	MLLT10
Triglycerides	1.34	3	1	2.2	0.00	1.0e+00	MSRA NRBF2 PRSS53
Chest pain or discomfort	1.33	1	0	0.0	0.00	1.0e+00	USP36
Chronotype (morning person)	1.30	5	1	2.2	0.98	2.7e-03	ADAM1A ALDH2 BRAP ERP29 NAA25
Major Depression (MDD)	1.28	1	0	0.0	0.00	1.0e+00	NT5C2
Rheumatoid Arthritis	1.28	1	0	0.0	0.00	1.0e+00	SH2B3
Average weekly beer plus cider intake	1.27	1	0	0.0	0.00	1.0e+00	RNF123
Age started oral contraceptive pill	1.26	1	0	0.0	0.00	1.0e+00	RNF123
Multivitamins +/- minerals	1.25	1	1	2.2	0.00	1.0e+00	REEP3
Myopia	1.25	1	0	0.0	0.00	1.0e+00	WNT2B
Number of incorrect matches in round	1.23	4	2	4.4	-1.00	4.0e-03	FES FURIN LOC100129961 PRSS53
Nervous feelings	1.23	3	1	2.2	0.00	1.0e+00	ADM ARNTL MSRA
Mouth/teeth dental problems: Mouth ulcers	1.23	1	0	0.0	0.00	1.0e+00	PREX1
Financial difficulties in last 2 years	1.22	1	0	0.0	0.00	1.0e+00	PRSS53
Vitamin and mineral supplements	1.19	1	0	0.0	0.00	1.0e+00	REEP3
Worry (Nagel 2018)	1.18	2	0	0.0	0.00	1.0e+00	ADM NT5C2
HbA1C	1.18	1	0	0.0	0.00	1.0e+00	ADAM1A
Hair/balding pattern: Pattern 2	1.18	1	1	2.2	0.00	1.0e+00	C4orf22
Suffer from 'nerves'	1.17	2	0	0.0	0.00	1.0e+00	MSRA RERE
Unable to work because of sickness or disability	1.17	1	0	0.0	0.00	1.0e+00	SLC5A11
Ever had bowel cancer screening	1.14	1	0	0.0	0.00	1.0e+00	RNF123
Average weekly fortified wine intake	1.12	1	0	0.0	0.00	1.0e+00	SLC5A11
Relative age of first facial hair	1.08	3	1	2.2	0.00	1.0e+00	C4orf22 MAP3K11 REEP3
Shortness of breath walking on level ground	1.08	2	0	0.0	0.00	1.0e+00	LMOD1 USP36
Ovarian Cancer	1.07	2	1	2.2	0.00	1.0e+00	ABO MLLT10
Number of full sisters	1.06	1	0	0.0	0.00	1.0e+00	NRBF2
Eye problems/disorders: Cataract	1.05	1	1	2.2	0.00	1.0e+00	SLC24A3
Financial situation satisfaction	1.03	1	0	0.0	0.00	1.0e+00	RNF123
Depression (self-reported)	1.00	1	0	0.0	0.00	1.0e+00	RERE
Hearing difficulty/problems: Yes	0.84	1	0	0.0	0.00	1.0e+00	C17orf81
Hair Pigment	0.41	26	22	48.9	-0.21	2.6e-01	ABCB9 ACHE ACP2 ADM ALDH2 ATP2B1 BRAP C20orf160 C4orf22 CTSW ERP29 FES GIGYF1 INTS4 LOC100129961 MAP3K11 MPHOSPH9 RERE RP11-282O18.3 RP11-91P24.7 SETD8 SH2B3 SIPA1 SNX32 TRIP6 ZNF831
Tanning	0.24	5	2	4.4	0.40	5.0e-01	ALDH2 ERP29 NRBF2 RP11-436D10.3 SH2B3

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Prostate	15	1.80	3.7
GTEx	Artery Aorta	49	1.65	3.6
GTEx	Ovary	18	1.98	3.6
GTEx	Adipose Visceral Omentum	36	1.77	3.5
GTEx	Artery Tibial	68	1.81	3.5
GTEx	Brain Frontal Cortex BA9	17	1.84	3.5
GTEx	Pancreas	30	1.84	3.5
GTEx	Small Intestine Terminal Ileum	8	1.74	3.5
GTEx	Stomach	22	1.51	3.5
GTEx	Artery Coronary	18	1.52	3.4
GTEx	Brain Caudate basal ganglia	12	1.30	3.4
GTEx	Brain Cerebellum	28	1.41	3.4
GTEx	Esophagus Gastroesophageal Junction	25	1.73	3.4
GTEx	Skin Not Sun Exposed Suprapubic	40	1.63	3.4
GTEx	Vagina	10	1.57	3.4
GTEx	Brain Cortex	19	1.84	3.3
GTEx	Brain Putamen basal ganglia	9	1.44	3.3
GTEx	Breast Mammary Tissue	35	1.77	3.3
GTEx	Cells EBV-transformed lymphocytes	18	1.26	3.3
GTEx	Colon Sigmoid	23	1.57	3.3
GTEx	Heart Left Ventricle	26	1.70	3.3
GTEx	Lung	46	1.60	3.3
GTEx	Pituitary	16	1.43	3.3
GTEx	Skin Sun Exposed Lower leg	55	1.51	3.3
GTEx	Adipose Subcutaneous	49	1.40	3.2
GTEx	Brain Cerebellar Hemisphere	22	1.48	3.2
GTEx	Brain Nucleus accumbens basal ganglia	12	1.39	3.2
GTEx	Breast Mammary Tissue (Male)	21	1.76	3.2
GTEx	Breast Mammary Tissue (Female)	20	1.22	3.2
GTEx	Cells Transformed fibroblasts	57	1.36	3.2
GTEx	Colon Transverse	33	1.60	3.2
GTEx	Esophagus Mucosa	53	1.60	3.2
GTEx	Esophagus Muscularis	47	1.45	3.2
GTEx	Heart Atrial Appendage	19	1.20	3.2
GTEx	Muscle Skeletal	40	1.38	3.2
GTEx	Nerve Tibial	67	1.55	3.2
GTEx	Spleen	13	0.92	3.2
GTEx	Testis	41	1.30	3.2
GTEx	Thyroid	54	1.35	3.2
GTEx	Whole Blood	28	1.40	3.2
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	28	1.69	3.2
The Cancer Genome Atlas	Colon Adenocarcinoma	29	1.40	3.2
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	26	1.57	3.2
GTEx	Brain Hippocampus	2	0.38	3.1
GTEx	Brain Hypothalamus	6	1.02	3.1
GTEx	Uterus	6	1.06	3.1
ROSMAP	Brain Pre-frontal Cortex	74	1.69	3.1
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	21	1.58	3.1
The Cancer Genome Atlas	Rectum Adenocarcinoma	8	1.16	3.1
GTEx	Adrenal Gland	22	1.51	3.0
GTEx	Liver	13	1.81	3.0
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	10	0.91	3.0
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	35	1.29	3.0
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	32	1.56	3.0
The Cancer Genome Atlas	Lung Adenocarcinoma	46	1.57	3.0
The Cancer Genome Atlas	Skin Cutaneous Melanoma	7	1.31	3.0
The Cancer Genome Atlas	Stomach Adenocarcinoma	21	1.25	3.0
The Cancer Genome Atlas	Testicular Germ Cell Tumors	14	1.09	3.0
NTR	Blood	21	0.87	2.9
CommonMind	Brain Pre-frontal Cortex	62	1.15	2.9
The Cancer Genome Atlas	Breast Invasive Carcinoma	56	1.27	2.9
The Cancer Genome Atlas	Esophageal Carcinoma	8	1.17	2.9
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	51	1.24	2.9
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	19	1.19	2.9
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	3	0.59	2.9
METSIM	Adipose	36	0.78	2.8
YFS	Blood	49	1.06	2.8
The Cancer Genome Atlas	Glioblastoma Multiforme	8	0.78	2.8
The Cancer Genome Atlas	Brain Lower Grade Glioma	41	0.95	2.8
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	11	0.99	2.8
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	27	1.08	2.8
The Cancer Genome Atlas	Prostate Adenocarcinoma	50	1.08	2.8
The Cancer Genome Atlas	Thyroid Carcinoma	51	0.99	2.8
The Cancer Genome Atlas	Soft Tissue Sarcoma	9	0.84	2.6