Best TWAS P=7.92e-09 · Best GWAS P=1.23e-06 conditioned to 0.906
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | EDEM3 | 0.23 | 0.16 | enet | 24 | 0.19 | 1.7e-14 | 4.8 | -5.8 | 7.9e-09 | -0.85 | 0.03 | 0.96 | TRUE |
| 2 | GTEx | Skin Sun Exposed Lower leg | EDEM3 | 0.09 | 0.09 | enet | 12 | 0.10 | 2.1e-08 | 4.8 | -5.2 | 1.9e-07 | -0.90 | 0.03 | 0.96 | FALSE |
| 3 | The Cancer Genome Atlas | Colon Adenocarcinoma | EDEM3 | 0.08 | 0.08 | blup | 66 | 0.10 | 1.3e-06 | 4.8 | -5.4 | 6.2e-08 | -0.86 | 0.04 | 0.94 | FALSE |
| 4 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | EDEM3 | 0.05 | 0.06 | enet | 7 | 0.08 | 8.7e-10 | 4.4 | -5.5 | 3.0e-08 | -0.80 | 0.08 | 0.89 | FALSE |
| 5 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | EDEM3 | 0.05 | 0.05 | blup | 67 | 0.06 | 1.0e-04 | -4.6 | -5.1 | 2.8e-07 | -0.96 | 0.04 | 0.93 | FALSE |
| 6 | The Cancer Genome Atlas | Rectum Adenocarcinoma | EDEM3 | 0.23 | 0.06 | blup | 67 | 0.03 | 6.3e-02 | -4.6 | -5.5 | 4.3e-08 | -0.71 | 0.02 | 0.36 | FALSE |