Best TWAS P=1.23e-10 · Best GWAS P=8.7e-15 conditioned to 4.63e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | LRIG2 | 0.05 | 0.01 | bslmm | 358 | 0.03 | 1.0e-04 | -3.1 | 5.4 | 7.1e-08 | 0.07 | 0.12 | 0.24 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | WNT2B | 0.43 | 0.46 | enet | 44 | 0.47 | 7.4e-64 | 5.3 | 5.9 | 3.3e-09 | 0.33 | 1.00 | 0.00 | TRUE |
| 3 | GTEx | Breast Mammary Tissue (Female) | WNT2B | 0.01 | -0.01 | enet | 24 | 0.00 | 3.4e-01 | 2.1 | -5.6 | 2.1e-08 | -0.11 | 0.03 | 0.06 | FALSE |
| 4 | GTEx | Esophagus Muscularis | SLC16A1 | 0.11 | 0.03 | lasso | 4 | 0.04 | 2.9e-03 | 5.1 | -5.9 | 4.6e-09 | 0.01 | 0.48 | 0.03 | TRUE |
| 5 | GTEx | Spleen | SLC16A1 | 0.16 | 0.08 | lasso | 5 | 0.07 | 8.3e-03 | -4.9 | -5.5 | 4.0e-08 | -0.04 | 0.11 | 0.16 | FALSE |
| 6 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | WNT2B | 0.05 | 0.02 | blup | 46 | 0.05 | 4.7e-04 | -4.9 | -6.0 | 2.0e-09 | -0.30 | 0.06 | 0.10 | FALSE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | RHOC | 0.04 | 0.03 | enet | 9 | 0.04 | 1.4e-04 | -5.6 | -6.4 | 1.2e-10 | -0.30 | 0.02 | 0.93 | TRUE |