Best TWAS P=1.21e-15 · Best GWAS P=4.81e-12 conditioned to 0.287
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellar Hemisphere | AGT | 0.67 | 0.50 | enet | 12 | 0.40 | 3.4e-11 | 6.2 | -6.2 | 4.7e-10 | -0.61 | 0.10 | 0.90 | FALSE |
| 2 | GTEx | Brain Cerebellum | AGT | 0.60 | 0.40 | lasso | 6 | 0.36 | 1.4e-11 | 6.5 | 6.7 | 1.7e-11 | 0.66 | 0.07 | 0.93 | FALSE |
| 3 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | AGT | 0.07 | 0.02 | enet | 12 | 0.04 | 1.8e-05 | 6.9 | 8.0 | 1.2e-15 | 0.78 | 0.01 | 0.99 | TRUE |
| 4 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | AGT | 0.11 | 0.05 | blup | 125 | 0.04 | 1.4e-03 | 5.8 | 5.5 | 4.6e-08 | 0.54 | 0.09 | 0.34 | FALSE |