Hub : Genes

AGT

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.2750 0.0370 0.0e+00 0.295 0.248 0.272 0.287 0.284 3.1e-36 5.9e-30 3.8e-33 3.3e-35 1.1e-34
2 GTEx Adipose Subcutaneous 0.1330 0.0450 2.1e-03 0.225 NA 0.211 NA 0.221 2.7e-18 NA 3.8e-17 NA 5.8e-18
3 GTEx Artery Tibial 0.2008 0.0529 6.0e-05 0.010 NA 0.031 NA 0.017 5.0e-02 NA 1.7e-03 NA 1.7e-02
4 GTEx Brain Cerebellar Hemisphere 0.6750 0.0980 7.7e-07 0.505 NA 0.395 NA -0.010 5.6e-15 NA 3.4e-11 NA 7.1e-01
5 GTEx Brain Cerebellum 0.6000 0.0890 1.1e-07 0.395 NA 0.201 NA 0.362 9.4e-13 NA 1.3e-06 NA 1.4e-11
6 GTEx Cells Transformed fibroblasts 0.3590 0.0680 1.4e-06 0.341 NA 0.305 NA 0.339 2.1e-26 NA 3.0e-23 NA 3.2e-26
7 GTEx Lung 0.1551 0.0550 3.4e-03 0.119 NA 0.113 NA 0.120 2.1e-09 NA 6.2e-09 NA 1.8e-09
8 GTEx Skin Not Sun Exposed Suprapubic 0.3160 0.0720 2.1e-05 0.376 NA 0.335 NA 0.374 9.1e-22 NA 5.0e-19 NA 1.2e-21
9 GTEx Skin Sun Exposed Lower leg 0.4710 0.0470 0.0e+00 0.456 NA 0.446 NA 0.453 1.3e-41 NA 2.1e-40 NA 2.5e-41
10 GTEx Testis 0.2910 0.0990 7.0e-03 0.058 NA 0.050 NA 0.095 1.4e-03 NA 2.8e-03 NA 5.4e-05
11 TCGA Colon Adenocarcinoma 0.0720 0.0320 1.8e-03 0.048 0.034 0.022 NA 0.036 8.7e-04 4.3e-03 1.9e-02 NA 3.6e-03
12 TCGA Kidney Renal Clear Cell Carcinoma 0.0669 0.0267 4.2e-05 0.023 0.041 0.041 NA 0.040 1.2e-03 2.1e-05 1.8e-05 NA 2.4e-05
13 TCGA Kidney Renal Papillary Cell Carcinoma 0.1140 0.0490 2.0e-03 0.054 0.044 0.021 NA 0.030 4.8e-04 1.4e-03 2.3e-02 NA 7.2e-03
14 TCGA Lung Adenocarcinoma 0.0495 0.0261 9.1e-03 0.035 0.015 0.036 NA 0.030 4.8e-05 5.8e-03 3.8e-05 NA 1.8e-04
15 TCGA Lung Squamous Cell Carcinoma 0.0775 0.0308 3.1e-04 0.056 0.041 0.045 NA 0.051 5.2e-07 1.7e-05 6.4e-06 NA 1.6e-06
16 TCGA Ovarian Serous Cystadenocarcinoma 0.0860 0.0430 6.9e-03 0.043 0.014 0.043 NA 0.048 6.4e-04 3.6e-02 6.6e-04 NA 3.6e-04
17 TCGA Prostate Adenocarcinoma 0.0505 0.0236 5.3e-03 0.029 0.014 0.016 NA 0.022 5.2e-04 1.2e-02 6.9e-03 NA 1.9e-03
18 TCGA Soft Tissue Sarcoma 0.1090 0.0450 1.8e-03 0.087 0.038 0.051 NA 0.062 7.6e-06 2.6e-03 5.3e-04 NA 1.5e-04
19 TCGA Skin Cutaneous Melanoma 0.3240 0.1070 2.0e-03 0.189 0.159 0.188 NA 0.198 9.0e-06 4.9e-05 9.3e-06 NA 5.4e-06
20 TCGA Thyroid Carcinoma 0.1840 0.0500 5.5e-09 0.111 0.106 0.097 NA 0.107 5.9e-11 1.8e-10 9.8e-10 NA 1.4e-10

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Bipolar Disorder (2018) 0.5 0.8 4.1 0.2 0.7 -2.0 -1.3 0.9 0.7 0.7 0.7 0.7 0.9 1.2 -0.1 0.9 0.5 0.7 1.5 0.8 0.7 0.6 0.0
Bipolar Disorder or Schizophrenia 1.6 3.8 5.9 -0.6 2.2 -1.2 -2.2 1.9 2.2 2.1 2.2 2.2 2.2 2.4 0.2 1.3 2.1 2.1 2.4 2.4 2.2 2.4 0.0
Depressed Affect (Nagel 2018) 0.8 1.6 7.3 1.1 -1.3 -0.2 1.2 -0.8 -1.3 -1.2 -1.3 -1.3 -0.6 -1.4 -0.6 -2.7 -0.7 -1.4 -1.5 -1.5 -1.3 -1.2 0.0
Depression (Nagel 2018) 0.7 1.0 4.0 1.2 -0.1 1.5 2.0 -1.6 -0.1 0.4 -0.1 -0.2 0.1 -1.7 -1.9 -1.3 0.4 -0.1 -1.0 -0.2 -0.1 -0.3 0.0
Intelligence (Savage-Jansen 2018) 0.2 0.5 2.3 -0.5 0.7 0.7 0.5 -0.9 0.7 0.4 0.7 0.7 0.4 -0.2 -1.2 -1.5 0.5 0.7 -0.5 0.6 0.6 0.2 0.0
Neuroticism (Nagel 2018) 0.1 0.3 1.6 -0.1 -0.6 0.1 0.1 0.0 -0.6 -0.6 -0.6 -0.6 -0.2 -0.4 0.3 -1.3 -0.9 -0.7 -0.7 -0.6 -0.6 -0.7 0.0
Schizophrenia (2018) 1.8 3.7 7.0 -0.9 2.2 0.1 -1.8 1.7 2.2 2.1 2.2 2.3 2.0 2.1 0.3 0.9 2.4 2.2 1.9 2.4 2.3 2.6 0.0
Schizophrenia vs Biploar Disorder 0.4 0.5 2.1 1.0 -0.6 0.5 1.0 -0.8 -0.6 -0.2 -0.6 -0.6 0.0 -1.4 -0.9 -1.4 0.2 -0.6 -0.7 -0.5 -0.6 0.0 0.0
Worry (Nagel 2018) 0.1 0.3 1.3 -0.4 -0.6 0.4 -0.5 0.2 -0.6 -0.5 -0.6 -0.6 -0.2 -0.0 0.7 0.2 -1.1 -0.6 -0.4 -0.5 -0.6 -0.8 0.0
Alzheimer’s Disease (in mother) 0.1 0.1 1.4 0.1 0.0 -0.1 0.2 0.4 0.0 -0.1 0.0 0.0 0.6 -0.1 -0.2 -1.2 -0.5 0.0 0.1 -0.3 -0.0 0.3 -0.2
Alzheimer’s Disease (in father) 1.0 1.1 4.2 1.1 -0.9 -0.7 1.4 -1.1 -0.9 -1.1 -0.9 -0.9 -0.7 -0.8 -1.1 -2.1 -1.3 -0.9 -1.0 -0.9 -0.9 -1.0 -0.9
Alzheimer’s Disease (including proxy) 0.7 1.0 8.0 0.3 -0.3 -0.8 1.6 -1.3 -0.3 -0.6 -0.3 -0.4 0.5 -0.6 -1.7 -2.8 -0.9 -0.4 -0.9 -0.7 -0.4 -0.5 -0.7
Crohns Disease (2017) 0.8 1.7 3.9 0.1 1.3 -0.8 -1.2 1.7 1.3 1.8 1.3 1.3 1.5 0.5 1.5 1.5 1.3 1.3 2.0 1.2 1.3 1.2 0.0
Irritable Bowel Disease (IBD) 1.4 3.4 6.7 -0.7 2.0 -0.1 -1.4 2.0 2.0 2.5 2.0 2.1 2.6 1.1 1.6 1.4 1.7 2.0 2.4 2.2 2.1 2.1 0.0
Ulcerative Colitis (UC) 1.6 3.1 7.4 -1.0 2.1 0.7 -1.0 1.4 2.1 2.3 2.1 2.1 2.7 1.0 1.1 0.6 1.4 2.0 1.9 2.3 2.1 2.2 0.0
Major Depression (MDD) 0.1 0.2 1.0 -0.1 0.2 1.0 0.5 0.1 0.2 0.2 0.2 0.2 -0.5 -0.0 -0.3 -0.4 -0.5 0.2 0.5 0.5 0.2 0.5 0.0
Reaction Time 0.1 0.2 1.2 -0.6 -0.3 -0.7 -0.3 0.4 -0.3 -0.6 -0.3 -0.3 -0.1 0.3 0.6 -0.3 -1.1 -0.3 -0.2 -0.2 -0.3 -0.0 0.1
Verbal and Numeric Reasoning (VNR) 0.2 0.5 2.1 -1.4 0.7 -0.3 -0.9 0.3 0.7 0.3 0.7 0.7 0.4 1.0 0.1 -0.3 1.4 0.7 0.0 0.7 0.7 0.5 0.4
Breast Cancer 2.1 5.0 7.6 -1.7 2.6 2.2 -2.0 2.2 2.6 1.9 2.6 2.6 1.4 2.3 1.8 2.1 1.9 2.6 1.1 2.5 2.7 2.2 2.8
Ovarian Cancer 0.2 0.2 0.8 0.1 -0.3 -0.4 0.2 0.1 -0.3 -0.6 -0.3 -0.3 -0.9 0.2 -0.8 -0.5 -0.3 -0.3 -0.5 -0.7 -0.4 -0.4 -0.7
Prostate Cancer 0.7 1.0 3.6 -0.6 -0.8 -0.5 -0.3 -0.5 -0.8 -1.6 -0.8 -0.8 -0.4 0.6 -1.2 -1.9 -1.3 -0.8 -1.2 -0.8 -0.8 -1.3 -1.1
Age at First Birth 0.2 0.3 1.7 -0.3 0.3 0.8 -0.0 -0.5 0.3 0.0 0.3 0.4 -0.5 -0.1 -0.1 -0.9 -1.3 0.3 0.1 0.6 0.4 0.7 0.8
Bipolar Disorder (2011) 4.5 4.3 9.3 -2.1 2.3 -1.3 -2.6 2.9 2.3 1.8 2.3 2.3 1.4 3.1 0.6 1.7 0.6 2.3 2.8 2.0 2.3 2.0 0.0
Body Mass Index (BMI) (2010) 0.9 1.3 2.0 1.1 -1.3 -0.6 1.1 -0.6 -1.3 -1.1 -1.3 -1.3 -1.4 -1.4 -0.6 -0.2 -0.2 -1.3 -1.0 -1.2 -1.3 -1.3 -1.2
Coronary Artery Disease (CAD) 1.8 2.2 11.5 -2.1 0.2 -2.2 -3.2 2.4 0.2 0.1 0.2 0.3 0.1 1.8 3.4 1.3 -0.9 0.2 0.8 0.2 0.3 0.5 0.0
Crohns Disease (2012) 0.9 1.4 4.6 -1.1 0.7 -1.9 -1.5 2.1 0.7 1.0 0.7 0.7 0.7 1.0 1.8 1.7 1.5 0.7 1.3 0.5 0.7 0.9 0.0
Mean Putamen Volume 0.3 0.4 2.7 0.3 0.2 1.6 0.4 -0.1 0.2 0.6 0.2 0.2 0.7 -0.3 0.2 0.9 0.6 0.2 -1.0 0.3 0.2 0.7 0.2
Fasting Glucose 0.4 0.4 2.1 -0.6 0.7 1.5 0.0 0.3 0.7 0.7 0.7 0.7 0.1 -0.2 -0.0 0.1 1.0 0.7 -0.3 0.5 0.7 1.0 0.6
HbA1C 1.2 1.3 2.7 -0.5 1.1 0.4 -1.2 1.5 1.1 0.9 1.1 1.2 1.0 1.3 0.8 0.8 1.3 1.1 1.1 1.6 1.2 1.1 1.4
HDL Cholesterol 0.2 0.3 1.0 -0.2 -0.6 0.4 0.0 -1.0 -0.6 -0.1 -0.6 -0.6 -0.7 -0.9 -0.2 -0.3 -0.4 -0.6 -0.3 -0.8 -0.6 -0.2 -0.8
LDL Cholesterol 0.3 0.4 1.1 -0.8 -0.6 -1.0 -0.8 0.8 -0.6 -1.1 -0.6 -0.6 -0.0 0.9 1.0 0.2 -0.6 -0.6 -0.5 -0.2 -0.5 -0.5 -0.2
Lupus 0.2 0.3 1.7 0.6 0.0 1.3 1.1 -0.9 0.0 0.1 0.0 0.0 0.1 -1.0 -0.3 -0.0 0.4 0.0 -0.6 0.3 0.0 0.3 0.0
Neuroticism (2016) 0.1 0.2 0.7 -0.6 -0.1 0.9 0.1 -0.2 -0.1 -0.2 -0.1 -0.1 0.1 0.0 -0.5 -0.7 0.3 -0.2 -0.9 -0.2 -0.2 -0.4 -0.1
Primary Biliary Cirrhosis 0.1 0.1 0.8 -0.2 -0.2 -0.9 -0.3 0.7 -0.2 -0.0 -0.2 -0.2 0.4 0.3 0.6 0.3 -0.1 -0.4 -0.0 -0.5 -0.4 -0.2 0.0
Rheumatoid Arthritis 2.1 2.8 10.4 0.6 -1.7 -1.2 2.0 -1.9 -1.7 -1.6 -1.7 -1.7 -1.2 -1.0 -2.6 -3.2 -1.2 -1.7 -0.9 -1.7 -1.7 -0.5 -1.5
Schizophrenia (2014) 2.5 5.5 9.2 -1.2 2.8 -0.4 -2.4 2.2 2.8 2.5 2.8 2.8 2.5 2.6 0.9 1.8 2.4 2.7 2.3 3.0 2.8 2.9 0.0
Triglycerides 0.6 1.0 3.1 0.1 0.8 -1.8 0.9 -0.3 0.8 0.9 0.8 0.8 1.7 0.5 -1.6 -0.7 1.0 0.8 1.1 1.0 0.8 0.9 1.0
Type 2 Diabetes (T2D) (2012) 0.5 0.6 3.4 0.0 -0.1 -1.8 -1.1 0.9 -0.1 0.0 -0.1 -0.1 0.3 1.1 1.3 1.2 -0.9 -0.1 1.1 -0.1 -0.1 -0.1 0.0
Ulcerative Colitis 0.2 0.2 1.2 -0.2 0.2 -0.2 -0.3 1.1 0.2 0.4 0.2 0.3 0.6 0.2 1.0 0.1 -0.4 0.2 0.8 0.5 0.3 0.4 0.0
Blood Eosinophil Count 0.1 0.9 3.5 0.4 0.8 1.6 -0.0 0.4 0.8 1.1 0.8 0.9 0.6 0.0 0.3 1.4 1.9 0.8 0.7 1.3 0.9 1.0 1.2
Blood Platelet Count 0.2 2.0 16.1 1.6 -0.5 0.1 2.3 -3.0 -0.5 -0.2 -0.5 -0.5 -0.2 -0.8 -4.0 -2.1 -0.6 -0.4 -0.4 -0.3 -0.5 -0.6 -0.4
Blood Red Count 0.0 0.4 1.4 -1.0 0.4 0.9 0.6 -0.2 0.4 0.3 0.4 0.4 0.4 0.3 -1.2 1.1 -0.7 0.5 0.5 0.3 0.4 0.0 0.2
Blood White Count 0.2 1.4 12.2 0.4 0.5 1.5 2.1 -2.1 0.5 0.5 0.5 0.5 -0.5 -0.9 -3.5 -0.5 0.8 0.6 -0.2 0.6 0.5 0.3 0.4
Heel T-Score 0.8 6.0 12.2 -3.5 2.6 -0.5 -2.4 2.1 2.6 2.5 2.6 2.6 2.6 2.8 1.4 2.7 1.7 2.6 2.3 2.4 2.5 2.7 2.3
BMI 0.1 0.4 2.4 0.8 -0.5 -1.6 0.0 1.2 -0.5 -0.5 -0.5 -0.5 -0.7 -0.4 0.1 -1.0 -0.2 -0.5 -0.6 -0.5 -0.5 -0.1 -0.3
Height 0.2 3.8 11.8 -2.3 1.7 0.5 -2.9 2.4 1.7 1.7 1.7 1.7 1.1 1.6 3.4 2.9 1.6 1.7 1.8 1.4 1.7 1.2 1.5
Waist Hip Ratio (WHR) 0.4 2.0 4.2 -2.0 1.7 -0.7 -0.4 1.0 1.7 1.6 1.7 1.8 1.1 1.2 -0.5 0.1 1.0 1.7 1.0 1.5 1.7 2.1 1.6
Systolic Blood Pressure 6.8 34.2 134.6 -4.5 2.8 -4.0 -11.1 11.6 2.8 1.9 2.8 2.9 3.4 7.3 11.5 9.3 1.3 2.8 5.0 3.3 2.9 2.6 3.1
Smoking Status 0.7 1.7 3.8 -1.1 1.6 1.0 0.7 -0.3 1.6 1.5 1.6 1.6 0.9 0.2 -1.9 -0.7 0.6 1.6 1.1 1.5 1.6 1.8 1.6
Allergy or Eczema 0.5 1.4 8.5 0.9 0.8 2.9 1.0 -0.9 0.8 1.3 0.8 0.8 0.0 -1.3 -0.1 0.4 2.3 0.8 -0.2 1.0 0.9 1.0 1.0
Cardiovascular Disease 5.8 19.1 67.2 -3.8 2.8 -2.2 -7.6 8.2 2.8 2.0 2.8 2.8 2.3 5.7 8.2 6.5 1.9 2.8 3.5 2.9 2.9 2.3 3.1
Hypothyroidism (self reported) 0.3 0.8 5.1 -0.2 -0.6 -2.2 -1.3 1.3 -0.6 -0.8 -0.6 -0.6 0.1 0.8 0.9 -0.7 -1.2 -0.6 0.5 -0.6 -0.6 -0.5 -0.4
Respiratory disease 0.5 1.1 1.8 1.3 -1.2 -0.1 0.6 -0.2 -1.2 -1.2 -1.2 -1.2 -1.0 -1.0 -0.3 -0.9 -1.0 -1.2 -0.9 -1.2 -1.3 -1.2 -1.3
Type 2 Diabetes (T2D) (2018) 0.9 1.7 3.5 -0.9 1.6 0.7 -0.1 0.2 1.6 1.5 1.6 1.6 1.5 0.8 -0.7 0.1 1.2 1.6 1.0 1.8 1.6 1.6 1.9
Lung FEV1/FVC ratio 0.5 2.5 8.6 -2.0 1.1 -2.3 -2.9 2.8 1.1 0.6 1.1 1.1 1.3 2.3 2.2 -0.0 0.4 1.1 1.5 0.8 1.1 1.0 0.9
Lung FVC 0.2 1.0 2.2 -1.1 1.0 -1.1 -0.5 0.5 1.0 1.1 1.0 1.0 1.5 1.3 -0.5 1.0 0.9 1.0 1.4 1.0 0.9 0.7 0.9
Neuroticism 0.2 0.5 1.2 -0.1 -0.8 0.5 0.4 -0.6 -0.8 -0.8 -0.8 -0.8 -0.8 -0.5 -0.3 -1.0 -0.7 -0.8 -1.0 -0.7 -0.8 -1.1 -0.7
Chronotype (morning person) 0.3 0.7 3.6 0.4 0.6 1.9 1.2 -1.5 0.6 1.2 0.6 0.6 -0.2 -1.1 -0.9 0.8 0.8 0.7 -0.4 0.2 0.5 0.4 0.2
Hair Pigment 0.0 1.3 4.4 0.6 1.2 2.1 0.7 -0.7 1.2 1.6 1.2 1.2 0.0 -0.5 -1.0 0.7 1.8 1.2 1.1 1.1 1.2 0.7 1.1
Tanning 0.1 1.7 6.4 -1.5 -1.3 0.4 -0.1 -0.6 -1.3 -1.8 -1.3 -1.3 -1.5 -0.6 0.5 -0.7 -1.5 -1.4 -2.5 -1.4 -1.4 -0.7 -1.6
Hand grip strength (left) 0.2 0.5 3.6 0.2 0.3 0.5 -1.1 0.8 0.3 0.7 0.3 0.3 0.2 -0.1 0.9 1.9 1.0 0.3 0.8 0.8 0.3 0.4 0.3
Number of treatments/medications taken 4.0 7.2 11.0 -2.2 2.8 -0.3 -3.1 3.3 2.8 2.8 2.8 2.8 2.8 2.5 2.5 2.6 2.9 2.8 2.6 2.7 2.8 2.5 3.1
Average weekly spirits intake 0.3 0.4 1.5 0.1 0.8 -0.6 0.1 -0.0 0.8 0.6 0.8 0.8 1.2 0.1 -0.5 -0.3 -0.0 0.8 0.6 0.4 0.7 0.4 0.4
Sensitivity / hurt feelings 0.4 0.6 3.7 -0.8 0.1 -0.2 -1.8 1.5 0.1 -0.4 0.1 0.1 -0.2 1.2 1.9 0.6 -0.7 0.1 0.1 0.1 0.1 -0.3 0.3
Frequency of depressed mood in last 2 weeks 0.7 1.0 5.4 0.5 0.7 2.3 1.3 -1.1 0.7 1.3 0.7 0.7 0.0 -1.1 -1.6 -0.1 1.3 0.7 -0.3 0.9 0.7 0.5 0.9
Hearing difficulty/problems: Yes 0.5 0.8 4.1 -0.7 -0.8 -0.5 -0.7 0.8 -0.8 -1.1 -0.8 -0.8 -0.9 0.1 2.0 -0.0 -1.4 -0.9 -0.5 -0.5 -0.8 -0.9 -0.5
Relative age of first facial hair 0.2 0.3 1.4 -0.9 0.2 -1.0 -1.0 0.4 0.2 0.0 0.2 0.2 0.4 1.2 -0.0 0.4 0.2 0.2 1.0 0.4 0.2 0.2 0.2
Other serious medical condition/disability diagnosed by doctor 2.6 3.4 4.9 -0.6 2.2 0.8 -1.6 1.7 2.2 2.1 2.2 2.2 1.6 1.5 0.6 1.6 2.2 2.2 1.8 2.0 2.2 1.8 2.1
Ever used hormone-replacement therapy (HRT) 1.0 1.3 3.1 -1.1 1.2 -1.0 -1.6 1.8 1.2 0.9 1.2 1.2 0.8 1.3 1.2 0.4 0.1 1.2 1.2 0.7 1.2 1.1 1.2
Ever had hysterectomy (womb removed) 0.3 0.3 0.7 0.2 0.7 0.2 0.3 -0.0 0.7 0.4 0.7 0.7 0.5 0.4 -0.7 0.0 0.9 0.7 -0.1 0.6 0.7 0.5 0.8
Systolic blood pressure, automated reading 3.5 10.2 64.0 -1.8 0.3 -2.4 -6.2 6.7 0.3 -0.1 0.3 0.3 0.8 3.1 8.0 5.5 -0.6 0.2 2.0 0.7 0.4 0.2 0.8
Eye problems/disorders: Diabetes related eye disease 0.5 0.6 5.2 -0.3 -0.4 -0.1 -1.0 1.4 -0.4 -0.4 -0.4 -0.4 0.0 0.0 2.3 0.8 -1.0 -0.4 -0.4 -0.5 -0.3 -0.3 -0.2
Angina 0.9 1.2 2.0 -0.6 1.3 0.7 -0.8 1.2 1.3 1.1 1.3 1.3 0.4 1.1 0.6 1.2 1.4 1.3 1.1 1.1 1.3 1.2 1.3
Medication for hormone replacement therapy 0.6 0.7 1.6 -1.0 0.9 -1.2 -0.5 0.7 0.9 0.7 0.9 0.9 0.0 1.0 -0.8 -0.0 0.7 0.9 1.2 0.8 0.9 0.8 0.9
Vitamin and mineral supplements 0.2 0.2 0.5 -0.3 0.5 0.4 -0.7 0.3 0.5 -0.2 0.5 0.5 -0.5 0.7 0.5 -0.0 0.7 0.4 0.2 0.6 0.5 0.1 0.5
Supplements: Zinc 0.9 1.0 3.6 -1.4 1.0 -0.9 -0.5 0.7 1.0 1.3 1.0 1.0 1.4 0.6 0.9 0.5 1.9 1.0 0.1 0.6 0.9 1.2 0.7
Medication: Co-codamol 0.2 0.2 1.1 1.0 0.0 0.6 0.8 -0.5 0.0 0.3 0.0 0.0 0.4 -0.8 -0.7 -0.5 0.6 0.0 -0.1 0.0 0.0 -0.1 0.2
Medication: Metformin 1.3 1.8 3.7 -0.5 1.3 1.1 -1.4 1.6 1.3 1.1 1.3 1.4 1.2 1.2 1.2 1.9 1.2 1.4 1.2 1.7 1.4 1.1 1.7
Diabetes (father) 0.2 0.2 1.2 0.1 -0.2 -0.2 0.7 -0.9 -0.2 -0.3 -0.2 -0.3 -0.2 -0.1 -0.9 -0.3 -0.6 -0.2 -1.1 -0.6 -0.3 -0.2 -0.6
Diabetes (mother) 0.2 0.3 1.5 -0.6 0.2 -0.5 -0.6 1.2 0.2 -0.4 0.2 0.1 -0.1 0.7 0.9 1.0 -0.0 0.2 -0.2 0.1 0.1 -0.3 -0.1
Severe depression (siblings) 1.3 1.4 3.3 0.1 -1.3 0.7 0.6 -0.7 -1.3 -1.3 -1.3 -1.3 -1.5 -0.8 -0.3 -0.8 -1.8 -1.3 -1.8 -1.5 -1.3 -1.1 -1.3
Pack years adult smoking proportion 0.4 0.7 3.6 1.9 -0.3 1.3 1.2 -0.9 -0.3 -0.0 -0.3 -0.3 -0.1 -1.2 -1.0 -1.1 -0.8 -0.3 -0.7 -0.3 -0.3 -0.3 0.0
Impedance of leg (right) 0.2 0.8 5.4 -0.5 0.8 2.3 0.0 -0.1 0.8 0.7 0.8 0.8 0.8 0.4 -0.3 1.1 1.4 0.9 0.5 0.9 0.8 0.2 0.5
Leg fat-free mass (left) 0.2 0.8 2.6 0.6 -1.0 -1.0 -0.6 1.0 -1.0 -0.8 -1.0 -1.0 -0.6 -0.8 1.6 0.2 -0.6 -1.0 -1.2 -1.0 -1.0 -0.6 -1.0
Trunk fat percentage 0.0 0.2 1.4 0.8 0.1 0.1 0.5 0.1 0.1 0.3 0.1 0.1 0.3 -1.2 -0.0 -0.4 0.5 0.1 -0.7 -0.2 0.1 -0.2 -0.2
Hand grip strength (right) 0.1 0.3 2.4 -0.2 -0.0 1.0 -0.7 0.3 -0.0 0.4 -0.0 0.0 0.0 -0.2 0.4 1.5 1.1 -0.0 0.1 0.6 0.0 0.6 0.2
Townsend deprivation index at recruitment 0.8 1.1 2.4 -0.8 1.3 1.0 0.4 -0.3 1.3 1.6 1.3 1.3 0.7 0.1 -0.6 0.3 1.4 1.3 0.6 1.1 1.3 1.4 1.1
Current tobacco smoking 1.0 1.7 4.0 -1.1 1.7 1.0 0.2 -0.5 1.7 1.6 1.7 1.7 0.9 -0.0 -1.1 -0.8 1.1 1.6 0.6 1.3 1.6 2.0 1.5
Average weekly fortified wine intake 1.8 2.1 5.7 -0.7 1.5 1.2 -1.9 1.6 1.5 1.1 1.5 1.5 2.1 1.2 2.4 2.0 1.0 1.5 0.7 1.1 1.4 1.0 1.1
Maternal smoking around birth 1.0 1.4 5.9 -1.1 0.8 1.2 -1.5 2.4 0.8 0.6 0.8 0.8 0.8 1.4 1.8 1.9 0.6 0.8 0.6 1.2 0.9 0.8 1.1
Fed-up feelings 0.2 0.4 0.8 -0.0 -0.6 0.8 0.4 -0.3 -0.6 -0.6 -0.6 -0.6 -0.9 -0.6 0.1 -0.5 -0.8 -0.6 -0.6 -0.7 -0.6 -0.8 -0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.4 3.3 0.9 -1.0 1.0 1.8 -1.6 -1.0 -0.7 -1.0 -1.0 -1.6 -1.8 -1.4 -1.1 -0.4 -1.0 -1.4 -0.9 -1.0 -1.0 -0.9
Relative age voice broke 0.1 0.2 0.4 0.2 -0.5 -0.6 0.1 -0.5 -0.5 -0.5 -0.5 -0.5 -0.4 -0.1 -0.5 -0.1 -0.4 -0.5 0.3 -0.5 -0.5 -0.6 -0.6
Taking other prescription medications 1.3 2.0 8.5 -1.4 1.1 -0.3 -2.2 2.9 1.1 0.8 1.1 1.2 1.0 1.7 2.1 0.7 0.8 1.1 1.0 1.1 1.2 1.1 1.5
Age when periods started (menarche) 0.9 2.3 4.5 -0.1 -1.8 0.7 1.0 -1.2 -1.8 -1.7 -1.8 -1.8 -2.1 -0.9 -0.4 -0.7 -1.8 -1.7 -1.7 -1.7 -1.8 -1.8 -1.7
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 1.2 0.2 -0.3 -0.9 0.3 -0.0 -0.3 -0.3 -0.3 -0.4 0.4 -0.5 -0.2 -1.1 -1.1 -0.3 -0.6 -0.8 -0.4 -0.7 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.0 3.5 -1.8 0.6 -1.2 -1.2 1.4 0.6 0.3 0.6 0.6 0.5 1.8 0.9 1.9 -0.3 0.7 1.1 0.5 0.6 0.3 0.5
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 1.0 1.0 -0.3 0.9 0.8 -0.9 -0.3 -0.2 -0.3 -0.3 0.1 -0.2 0.3 -1.0 0.8 -0.3 -0.9 -0.1 -0.2 -0.3 -0.1
Qualifications: CSEs or equivalent 0.2 0.3 1.8 -0.0 0.4 0.9 0.8 -0.6 0.4 0.6 0.4 0.4 -0.0 -0.6 -1.3 -0.4 0.2 0.4 -0.1 0.6 0.4 0.7 0.3
Serious illness, injury or assault to yourself 1.1 1.3 2.7 -0.9 1.2 1.3 -0.8 1.1 1.2 0.9 1.2 1.3 1.5 0.7 0.9 0.6 1.2 1.2 0.8 1.4 1.3 0.9 1.6
High blood pressure 4.4 12.2 47.2 -2.5 2.2 -1.5 -6.2 6.4 2.2 1.8 2.2 2.3 2.3 3.9 6.9 5.6 0.9 2.2 3.0 2.2 2.3 1.8 2.5
Hayfever, allergic rhinitis or eczema 0.2 0.5 4.9 0.8 0.1 2.2 0.5 -0.2 0.1 0.5 0.1 0.1 -0.4 -0.9 0.2 0.8 1.6 0.1 -0.5 0.2 0.1 0.2 0.2
Multivitamins +/- minerals 0.7 0.8 1.5 0.5 -1.2 0.4 0.1 -0.2 -1.2 -0.6 -1.2 -1.2 -0.1 -1.0 0.7 0.6 -1.2 -1.2 -0.8 -1.1 -1.2 -0.9 -1.1
Stomach or abdominal pain in last month 0.1 0.1 0.2 0.5 -0.3 0.4 -0.1 0.5 -0.3 -0.1 -0.3 -0.3 -0.3 -0.3 0.1 -0.2 -0.3 -0.3 -0.4 -0.2 -0.2 -0.4 -0.1
Supplements: Glucosamine 1.3 1.7 3.4 -0.3 -1.6 -1.3 -0.5 0.4 -1.6 -1.4 -1.6 -1.6 -0.6 -0.2 1.2 -1.0 -1.5 -1.7 -1.2 -1.8 -1.6 -0.9 -1.7
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 2.1 1.5 -0.9 0.2 1.1 -0.6 -0.9 -0.6 -0.9 -0.9 -0.7 -1.1 -1.0 -0.3 0.2 -0.8 -0.5 -0.8 -0.9 -1.1 -1.0
Medication: Atenolol 5.6 7.0 14.1 -2.2 2.6 -0.2 -3.8 3.6 2.6 2.1 2.6 2.6 2.7 3.1 3.4 2.6 1.9 2.6 1.8 2.4 2.7 2.8 2.6
Medication: Levothyroxine sodium 0.5 0.8 1.8 -1.1 1.0 -0.0 -0.8 0.8 1.0 0.6 1.0 1.0 1.1 1.3 -0.1 -0.4 0.2 0.9 0.4 1.0 1.0 1.2 1.2
Sitting height 0.1 1.0 4.3 -0.3 0.6 0.5 -1.6 1.5 0.6 0.9 0.6 0.6 1.3 0.1 1.9 2.1 1.3 0.6 0.4 0.7 0.6 0.2 0.4
Chronic bronchitis/emphysema (father) 5.9 6.9 10.0 2.4 -3.0 -0.9 2.9 -2.9 -3.0 -2.4 -3.0 -3.0 -2.1 -2.6 -2.3 -3.2 -2.7 -3.0 -1.3 -2.5 -3.0 -2.4 -2.5
High blood pressure (mother) 4.3 6.0 22.2 -2.1 1.4 -1.4 -4.6 4.7 1.4 1.2 1.4 1.4 1.4 3.1 4.7 3.5 0.0 1.3 2.5 1.6 1.4 1.4 1.5
Body mass index (BMI) 0.1 0.5 2.1 1.2 -0.3 -1.0 1.1 -0.3 -0.3 -0.2 -0.3 -0.3 -0.4 -1.2 -0.9 -1.4 -0.3 -0.4 -0.7 -0.4 -0.3 0.1 -0.2
Impedance of leg (left) 0.2 1.0 3.5 -0.6 1.1 1.9 0.1 -0.1 1.1 1.1 1.1 1.0 1.2 0.5 -0.7 0.9 1.5 1.1 1.0 1.0 1.0 0.4 0.7
Leg predicted mass (left) 0.2 0.8 2.5 0.6 -1.0 -0.9 -0.5 0.9 -1.0 -0.8 -1.0 -1.0 -0.7 -0.9 1.6 0.2 -0.6 -1.0 -1.2 -1.0 -1.0 -0.7 -1.0
Trunk fat mass 0.0 0.1 1.3 0.6 0.0 -0.2 0.3 0.3 0.0 0.2 0.0 -0.0 0.1 -1.1 0.4 -0.2 0.4 -0.0 -0.8 -0.3 -0.1 -0.2 -0.3
Waist circumference 0.1 0.2 1.9 0.3 -0.1 -1.4 0.5 0.3 -0.1 0.0 -0.1 -0.1 -0.2 -0.8 -0.2 -0.9 -0.3 -0.2 -0.5 -0.3 -0.1 0.2 -0.1
Number of incorrect matches in round 0.6 1.0 3.6 -0.7 -1.0 -1.9 0.3 -0.2 -1.0 -1.0 -1.0 -0.9 -1.3 -0.1 0.2 -1.4 -1.9 -1.0 -0.4 -0.9 -0.9 -0.4 -0.8
Past tobacco smoking 1.3 2.4 3.8 1.5 -1.8 -0.1 1.4 -1.9 -1.8 -1.3 -1.8 -1.8 -1.5 -1.6 -0.3 -1.2 -1.1 -1.8 -1.9 -1.7 -1.8 -1.8 -1.7
Alcohol usually taken with meals 0.3 0.4 3.1 1.8 -0.5 0.3 0.0 0.0 -0.5 -0.2 -0.5 -0.5 -0.1 -0.4 0.7 0.9 0.2 -0.5 -0.3 -0.6 -0.5 -1.1 -0.6
Nervous feelings 0.1 0.2 1.9 -0.9 0.2 1.4 -0.4 0.2 0.2 0.4 0.2 0.3 0.3 0.1 0.4 0.1 0.0 0.2 -0.2 0.3 0.3 0.6 0.4
Frequency of tenseness / restlessness in last 2 weeks 1.1 1.6 4.2 2.1 -1.0 1.4 1.9 -1.3 -1.0 -0.4 -1.0 -1.0 -1.7 -1.9 -1.8 -1.3 -0.1 -1.0 -1.1 -0.8 -1.0 -1.2 -0.8
Hearing difficulty/problems with background noise 1.4 2.2 4.2 -1.7 1.5 -0.5 -1.9 2.1 1.5 1.1 1.5 1.5 1.1 1.7 1.9 1.0 1.3 1.4 1.5 1.4 1.5 1.1 1.6
Hair/balding pattern: Pattern 2 0.5 0.6 2.2 -0.4 0.9 -0.3 -0.9 0.9 0.9 0.6 0.9 0.8 1.5 1.3 0.1 -0.1 -0.3 0.9 1.1 0.5 0.8 0.3 0.5
Had menopause 0.5 0.6 4.0 -1.0 0.4 -2.0 -1.2 0.8 0.4 0.1 0.4 0.4 0.2 0.9 1.4 0.3 -0.6 0.3 1.0 0.2 0.4 0.6 0.5
Had other major operations 0.3 0.4 1.8 1.0 0.1 0.4 1.4 -0.9 0.1 0.8 0.1 0.1 -0.4 -1.2 -0.8 0.1 0.8 0.1 -0.3 -0.0 0.1 0.5 0.1
Forced vital capacity (FVC) 0.4 1.5 6.3 -1.5 0.4 -0.5 -2.2 2.1 0.4 0.3 0.4 0.5 0.7 1.5 2.5 2.1 1.0 0.4 0.9 0.9 0.5 0.4 0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.3 4.2 -1.6 1.0 -1.8 -1.1 1.5 1.0 0.6 1.0 1.0 0.9 2.1 0.3 1.8 0.5 1.0 1.2 0.8 0.9 0.5 0.8
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 2.5 -0.8 -0.9 -0.4 -0.0 0.4 -0.9 -0.6 -0.9 -0.8 -1.6 -0.2 0.9 0.5 -0.3 -0.9 -0.7 -0.7 -0.8 -0.4 -0.7
Qualifications: None of the above 0.4 0.9 2.3 0.1 1.0 0.6 1.2 -0.7 1.0 1.3 1.0 1.0 0.2 -0.4 -0.9 -0.1 0.6 1.0 0.8 1.2 1.1 1.3 1.5
Financial difficulties in last 2 years 0.3 0.4 2.9 -0.4 0.1 0.7 1.2 -0.8 0.1 -0.3 0.1 0.1 -0.6 0.1 -1.7 -1.0 0.2 0.1 -1.1 0.1 0.1 -0.1 0.0
Mouth/teeth dental problems 1.2 1.8 5.3 0.3 -1.4 0.7 0.5 -0.8 -1.4 -1.7 -1.4 -1.5 -1.5 -1.0 -0.2 -0.3 -0.1 -1.4 -2.3 -1.8 -1.5 -2.0 -2.0
Heart attack 1.5 1.9 9.2 -1.0 0.9 0.3 -2.3 2.8 0.9 0.6 0.9 0.9 0.4 1.4 3.0 2.1 0.5 0.9 1.0 0.8 0.9 0.9 1.1
Allergy 0.2 0.5 5.3 -1.1 0.1 -2.3 -0.7 -0.0 0.1 -0.2 0.1 0.1 -0.1 1.1 -0.1 -0.2 -1.4 0.1 0.8 0.0 0.1 -0.0 -0.0
Pain all over the body in last month 0.5 0.5 2.7 0.0 -0.2 0.6 1.6 -0.8 -0.2 0.1 -0.2 -0.2 -0.2 -1.2 -1.6 -1.4 -0.4 -0.2 -0.5 -0.2 -0.2 0.2 -0.1
Diabetes (self-reported) 0.4 0.6 1.3 -0.2 0.9 0.4 -0.1 -0.0 0.9 1.0 0.9 0.9 0.9 0.1 0.5 0.7 0.9 0.9 0.7 1.1 0.9 0.8 1.1
Hayfever/allergic rhinitis (self-reported) 0.4 0.6 2.5 0.8 -0.2 0.5 -1.4 1.4 -0.2 -0.3 -0.2 -0.2 -0.4 0.4 1.5 1.6 0.3 -0.2 0.6 0.0 -0.2 -0.5 0.1
Medication: Ramipril 1.2 1.6 7.2 -0.9 0.7 -0.2 -2.4 2.7 0.7 0.3 0.7 0.7 1.0 1.5 2.5 1.7 -0.4 0.7 1.2 0.5 0.7 0.3 0.7
Medication: Simvastatin 3.6 5.3 6.7 -2.5 2.5 0.8 -2.3 2.4 2.5 2.2 2.5 2.5 2.0 2.4 2.6 2.4 1.8 2.5 1.4 2.3 2.5 2.4 2.6
Fluid intelligence score 0.6 1.2 2.9 -1.1 1.1 -0.8 -1.5 1.1 1.1 0.9 1.1 1.1 0.6 1.4 0.5 0.6 1.7 1.1 1.2 1.0 1.1 0.9 0.9
Illnesses of siblings 2.6 3.6 6.3 0.2 -2.2 -0.0 1.8 -2.5 -2.2 -2.2 -2.2 -2.2 -1.5 -1.1 -2.1 -1.7 -1.1 -2.2 -1.8 -1.9 -2.2 -1.9 -2.2
Neuroticism score 0.0 0.1 0.5 -0.3 -0.2 0.7 -0.6 0.3 -0.2 -0.1 -0.2 -0.2 -0.1 0.1 0.3 0.1 -0.4 -0.2 -0.1 -0.1 -0.1 -0.5 -0.0
Weight 0.0 0.2 0.7 0.1 -0.2 -0.8 -0.3 0.7 -0.2 -0.1 -0.2 -0.2 -0.1 -0.6 0.8 -0.0 0.1 -0.2 -0.7 -0.3 -0.2 0.1 -0.2
Impedance of arm (right) 0.2 1.1 2.5 -1.4 1.0 1.2 -1.4 1.1 1.0 0.7 1.0 0.9 1.3 1.4 1.0 1.6 0.7 1.0 0.8 0.9 0.9 0.3 0.7
Arm fat percentage (right) 0.1 0.4 1.6 1.2 -0.3 -0.4 0.9 -0.3 -0.3 -0.1 -0.3 -0.3 -0.4 -1.3 -0.6 -1.1 -0.1 -0.3 -0.7 -0.4 -0.3 -0.2 -0.3
Trunk fat-free mass 0.1 0.5 3.5 -0.3 -0.3 -1.0 -1.2 1.3 -0.3 -0.2 -0.3 -0.3 -0.5 -0.1 1.9 0.8 0.2 -0.3 -0.4 -0.4 -0.3 0.1 -0.4
Hip circumference 0.1 0.4 1.0 0.9 -0.8 -1.0 0.1 0.5 -0.8 -0.7 -0.8 -0.8 -0.3 -0.7 0.2 -0.1 -0.4 -0.8 -0.6 -0.7 -0.8 -0.8 -0.6
Time employed in main current job 1.0 1.2 4.1 -1.4 -0.9 -0.3 0.4 -1.4 -0.9 -1.2 -0.9 -0.9 -2.0 -0.3 -0.0 -1.3 -1.1 -0.9 -1.6 -1.3 -1.0 -0.5 -1.2
Alcohol intake versus 10 years previously 0.5 0.7 1.4 -1.1 1.0 1.1 -0.3 0.6 1.0 0.9 1.0 1.0 0.0 0.6 -0.0 0.4 0.7 1.0 0.6 0.9 1.0 1.2 0.9
Father’s age at death 2.1 2.8 10.0 2.0 -1.2 0.3 2.8 -3.2 -1.2 -0.6 -1.2 -1.2 -1.3 -2.5 -2.4 -2.3 0.2 -1.2 -0.9 -1.4 -1.2 -1.0 -1.5
Worrier / anxious feelings 0.3 0.6 2.2 -0.3 0.8 1.5 -0.9 0.7 0.8 0.8 0.8 0.8 0.5 0.6 0.6 0.8 0.2 0.8 0.8 0.8 0.8 0.1 0.8
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 0.8 0.5 -0.1 0.6 -0.2 0.9 -0.1 0.0 -0.1 -0.1 -0.1 -0.3 0.2 0.1 0.3 -0.1 -0.4 -0.1 -0.1 -0.6 -0.1
Falls in the last year 0.8 1.1 3.8 1.3 -0.6 1.0 1.5 -1.8 -0.6 -0.5 -0.6 -0.6 -0.4 -2.0 -0.4 -1.5 0.3 -0.6 -1.2 -0.9 -0.7 -0.8 -0.9
Hair/balding pattern: Pattern 3 0.3 0.4 3.2 -0.1 -0.4 0.9 -0.5 0.3 -0.4 -0.4 -0.4 -0.4 -1.0 -0.3 1.8 1.0 0.3 -0.4 -0.6 -0.4 -0.4 -0.4 -0.4
Number of live births 2.0 2.9 5.6 -2.0 1.5 -1.2 -2.0 2.2 1.5 1.2 1.5 1.5 1.1 2.4 1.1 1.5 1.6 1.5 2.2 1.7 1.5 2.0 1.7
Forced expiratory volume in 1-second (FEV1) 0.6 1.9 10.2 -1.5 0.1 -1.0 -2.6 2.6 0.1 -0.0 0.1 0.2 0.3 1.7 3.2 2.3 0.9 0.1 0.8 0.7 0.2 0.3 0.4
Pulse rate 1.3 2.2 7.0 2.6 -1.0 2.1 2.0 -2.4 -1.0 -0.2 -1.0 -1.0 -1.2 -2.7 -0.9 -1.5 0.5 -1.0 -1.2 -0.9 -1.0 -1.2 -1.0
Happiness 0.3 0.3 1.6 1.1 0.2 0.8 -0.5 0.6 0.2 0.8 0.2 0.1 -0.2 -0.5 0.9 1.2 1.0 0.1 0.4 0.1 0.1 0.0 0.1
Noisy workplace 0.5 0.7 2.0 0.6 -0.7 0.5 0.7 -0.2 -0.7 -0.4 -0.7 -0.7 -1.4 -1.4 0.6 -0.2 -1.4 -0.7 -0.7 -0.9 -0.8 -0.6 -1.0
Qualifications: A levels/AS levels or equivalent 0.1 0.2 1.2 0.0 0.1 0.2 -0.4 -0.3 0.1 0.5 0.1 0.1 1.0 0.1 -0.0 1.1 0.1 0.2 0.5 0.3 0.1 -0.1 0.1
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 1.1 0.7 -0.3 0.1 1.0 -0.9 -0.3 0.1 -0.3 -0.3 -0.8 -1.0 -0.9 0.1 -0.7 -0.3 -0.1 -0.2 -0.3 -0.2 -0.3
Mouth/teeth dental problems: Dentures 0.4 0.7 1.5 0.1 1.0 -0.5 0.2 0.2 1.0 1.2 1.0 1.0 1.2 -0.0 0.0 -0.6 0.1 1.0 0.7 0.7 1.0 0.9 1.0
Asthma 0.1 0.3 0.9 0.8 -0.6 -0.6 -0.4 0.9 -0.6 -0.6 -0.6 -0.6 -0.1 0.1 -0.1 -0.3 -0.4 -0.6 -0.0 -0.4 -0.5 -0.5 -0.5
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.2 0.9 0.5 -0.1 0.7 0.8 -0.6 -0.1 0.3 -0.1 -0.2 0.3 -0.9 -0.3 -0.6 -0.2 -0.2 -0.2 -0.4 -0.2 0.0 -0.2
Medication: Cholesterol lowering 3.7 5.7 9.1 -2.8 2.6 1.2 -3.0 2.9 2.6 1.9 2.6 2.6 1.6 3.0 2.1 2.3 1.4 2.6 1.7 2.3 2.6 2.5 2.6
Depression (self-reported) 0.8 1.0 3.5 -1.1 0.7 -1.6 -1.9 1.7 0.7 0.6 0.7 0.7 0.1 1.5 1.1 1.2 0.3 0.7 0.6 0.7 0.7 0.5 0.6
Medication: Lansoprazole 0.9 1.0 3.7 -0.3 0.8 -0.7 -1.6 1.8 0.8 1.1 0.8 0.8 -0.1 0.6 1.9 0.9 0.5 0.8 1.1 0.5 0.8 0.8 0.9
Prospective memory result 1.8 2.2 6.9 1.3 -1.2 0.8 2.4 -2.0 -1.2 -1.2 -1.2 -1.2 -1.7 -1.7 -2.6 -1.9 -1.1 -1.1 -1.4 -1.0 -1.1 -1.3 -0.9
Lung cancer (father) 0.5 0.6 1.1 -0.2 0.9 0.2 -0.2 0.7 0.9 0.6 0.9 0.9 1.0 1.1 -0.7 0.7 0.2 0.9 0.8 0.8 0.9 0.5 0.7
Illnesses of mother 4.0 4.9 17.1 1.9 -1.6 2.2 3.6 -4.1 -1.6 -1.4 -1.6 -1.6 -2.2 -2.8 -3.1 -2.2 0.2 -1.6 -2.8 -1.6 -1.6 -1.4 -1.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 2.0 8.4 -2.4 0.2 -0.6 -2.8 2.7 0.2 -0.4 0.2 0.2 -0.2 2.1 2.9 1.9 0.8 0.2 0.3 0.6 0.2 0.3 0.2
Pulse wave Arterial Stiffness index 2.6 3.0 5.8 0.4 -2.0 -0.7 0.5 -0.4 -2.0 -2.2 -2.0 -2.0 -2.0 -1.1 0.8 -0.9 -1.5 -2.0 -2.3 -2.4 -2.0 -2.4 -2.3
Impedance of arm (left) 0.3 1.2 2.9 -1.7 0.9 1.1 -1.4 1.1 0.9 0.6 0.9 0.9 1.5 1.6 0.9 1.7 0.7 0.9 0.8 0.9 0.8 0.3 0.7
Arm fat mass (right) 0.1 0.3 1.0 0.7 -0.4 -0.8 0.5 0.1 -0.4 -0.3 -0.4 -0.4 -0.5 -1.0 -0.3 -0.9 -0.2 -0.4 -0.9 -0.5 -0.4 -0.2 -0.5
Trunk predicted mass 0.1 0.5 3.8 -0.3 -0.3 -1.0 -1.2 1.3 -0.3 -0.3 -0.3 -0.3 -0.6 -0.1 1.9 0.9 0.2 -0.3 -0.4 -0.4 -0.3 0.0 -0.4
Standing height 0.2 2.1 10.4 -2.4 0.4 0.1 -2.8 2.2 0.4 0.1 0.4 0.4 0.6 1.5 3.2 2.7 1.0 0.4 0.2 0.3 0.4 0.1 0.0
Length of working week for main job 0.1 0.2 0.6 -0.3 -0.4 -0.6 -0.5 -0.1 -0.4 -0.5 -0.4 -0.4 -0.2 0.3 0.1 -0.8 -0.2 -0.4 -0.3 -0.3 -0.4 -0.1 -0.4
Exposure to tobacco smoke at home 0.5 0.5 1.4 1.1 -0.7 -0.1 0.8 -0.9 -0.7 -0.3 -0.7 -0.7 -0.5 -0.9 -1.0 -1.2 -0.5 -0.7 -0.4 -0.7 -0.6 -0.4 -0.6
Breastfed as a baby 1.6 2.0 6.9 0.4 -1.5 -0.3 1.0 -1.3 -1.5 -1.8 -1.5 -1.5 -1.3 -0.7 -1.4 -2.6 -1.4 -1.5 -1.0 -1.6 -1.5 -1.4 -1.6
Tense / ‘highly strung’ 0.4 0.7 4.3 -0.0 -0.1 -0.4 -1.6 1.7 -0.1 0.1 -0.1 -0.2 0.1 0.5 2.1 1.5 -0.4 -0.2 0.4 -0.1 -0.1 -0.4 -0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 1.2 1.8 5.7 -0.5 -1.5 1.5 0.8 -0.7 -1.5 -1.2 -1.5 -1.5 -1.4 -1.2 0.2 -0.5 -1.3 -1.5 -2.4 -1.7 -1.5 -1.4 -1.5
Hair/balding pattern: Pattern 4 0.4 0.9 6.9 -0.3 -0.0 -0.9 1.8 -1.6 -0.0 0.1 -0.0 -0.1 -0.3 -0.6 -2.6 -1.8 0.0 -0.1 -0.3 -0.2 -0.1 0.0 -0.2
Birth weight of first child 1.2 2.1 4.5 0.3 -1.5 0.3 2.0 -2.1 -1.5 -1.4 -1.5 -1.5 -1.7 -1.5 -1.5 -1.3 -0.5 -1.4 -1.9 -1.4 -1.5 -1.4 -1.5
Peak expiratory flow (PEF) 0.9 2.0 14.1 -0.4 -0.6 -1.4 -2.8 2.8 -0.6 -0.7 -0.6 -0.6 -0.1 1.2 3.8 2.0 -0.2 -0.7 0.1 0.0 -0.5 -0.1 -0.3
Pulse wave reflection index 0.8 1.0 4.0 -1.5 0.1 -1.9 -1.8 2.0 0.1 -0.6 0.1 0.1 0.7 1.7 1.7 0.8 -0.7 0.1 0.3 -0.3 0.0 -0.2 -0.2
Ever highly irritable/argumentative for 2 days 2.1 2.5 6.2 -1.2 1.4 -0.3 -1.9 2.5 1.4 1.7 1.4 1.4 1.3 1.1 1.9 2.1 0.8 1.3 2.0 1.6 1.4 1.9 1.7
Loud music exposure frequency 0.5 0.5 2.6 0.9 -0.2 -0.7 1.6 -1.2 -0.2 0.3 -0.2 -0.2 0.1 -1.0 -1.6 -0.8 -0.3 -0.2 0.6 -0.3 -0.2 -0.2 -0.3
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 1.3 -0.7 -0.0 0.5 -0.1 -0.1 -0.0 -0.3 -0.0 -0.1 0.1 0.3 -0.9 -0.9 -1.2 0.0 -0.5 -0.5 -0.1 -0.3 -0.7
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 4.1 1.5 0.5 -1.3 0.5 -0.3 0.5 1.0 0.5 0.5 0.7 0.0 -0.9 -0.1 0.3 0.5 2.0 1.3 0.6 1.2 1.2
Blood clot in the leg (DVT) 0.7 0.9 4.2 0.5 -0.3 1.4 2.1 -1.5 -0.3 -0.2 -0.3 -0.3 -0.5 -1.6 -1.3 -1.0 0.4 -0.3 -1.3 -0.4 -0.3 -0.6 -0.2
Medication: Paracetamol 0.9 1.5 6.8 0.7 1.3 0.8 0.9 -0.9 1.3 1.6 1.3 1.3 1.4 -0.4 -1.6 -0.6 2.6 1.3 0.2 1.0 1.3 0.9 1.2
Headache pain in last month 0.9 1.6 3.4 1.8 -1.3 1.6 0.8 -1.0 -1.3 -1.0 -1.3 -1.3 -1.1 -1.6 -0.2 -1.2 -0.9 -1.3 -1.8 -1.3 -1.2 -1.4 -1.2
Medication for cholesterol, blood pressure or diabetes 1.6 2.7 9.7 1.6 -1.3 -1.1 2.7 -2.8 -1.3 -0.9 -1.3 -1.3 -1.2 -1.8 -3.1 -2.0 -0.3 -1.3 -1.1 -1.1 -1.3 -1.1 -1.4
Glaucoma (self-reported) 1.8 2.1 8.8 0.9 -1.1 1.5 2.3 -2.6 -1.1 -0.7 -1.1 -1.1 -0.8 -1.6 -3.0 -1.7 -0.3 -1.1 -1.3 -0.8 -1.1 -0.6 -1.0
Gout (self-reported) 0.3 0.3 1.9 0.4 -0.2 1.4 1.3 -1.3 -0.2 -0.1 -0.2 -0.2 0.1 -0.6 -0.8 -0.2 -0.6 -0.2 -0.1 0.3 -0.2 -0.2 -0.0
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 3.1 -1.1 0.6 -1.5 -1.7 1.8 0.6 0.2 0.6 0.6 1.1 1.6 1.4 -0.2 -0.0 0.6 0.9 0.5 0.6 0.5 0.8
Medication: Amlodipine 1.2 1.6 7.5 -2.7 1.0 -0.3 -2.0 1.8 1.0 0.4 1.0 1.0 1.4 1.6 1.6 0.7 -0.0 1.0 0.8 1.0 1.0 1.3 1.0
Medication: Ventolin 100micrograms inhaler 2.9 3.8 7.3 1.5 -1.9 0.8 2.7 -2.2 -1.9 -1.9 -1.9 -1.9 -1.7 -2.0 -2.7 -2.7 -1.1 -1.9 -1.8 -1.6 -1.9 -1.9 -1.6
Birth weight 0.1 0.3 1.3 -0.5 0.2 0.4 0.7 -1.2 0.2 0.2 0.2 0.2 0.1 -0.3 -1.1 -0.1 1.1 0.2 -0.1 0.6 0.2 0.3 0.2
Chronic bronchitis/emphysema (mother) 0.2 0.2 1.1 -1.0 0.3 1.0 0.1 0.1 0.3 -0.1 0.3 0.3 -0.2 0.2 -0.3 -0.4 -0.0 0.3 -0.3 0.5 0.3 0.6 0.4
High blood pressure (siblings) 2.0 2.9 8.7 -1.2 1.5 -1.2 -2.3 2.9 1.5 1.3 1.5 1.5 1.8 2.0 2.4 1.7 0.4 1.5 1.9 1.4 1.5 1.4 1.7
Forced vital capacity (FVC), Best measure 0.5 1.8 6.7 -2.6 0.4 -0.3 -2.5 2.3 0.4 -0.2 0.4 0.5 -0.0 2.1 2.4 2.2 0.9 0.4 0.3 0.9 0.5 0.5 0.5
Body fat percentage 0.1 0.2 1.7 1.0 0.1 -0.0 0.8 -0.1 0.1 0.3 0.1 0.1 0.2 -1.3 -0.4 -0.6 0.2 0.1 -0.6 -0.1 0.1 -0.1 -0.1
Leg fat percentage (right) 0.2 0.6 2.9 1.4 -0.1 0.2 1.6 -1.0 -0.1 0.1 -0.1 -0.1 -0.5 -1.7 -1.4 -1.2 0.0 -0.1 -0.9 -0.3 -0.1 -0.2 -0.2
Arm fat-free mass (right) 0.1 0.3 1.7 0.2 -0.4 -0.8 -0.5 0.9 -0.4 -0.2 -0.4 -0.4 -0.5 -0.5 1.3 0.6 0.5 -0.4 -0.6 -0.4 -0.4 -0.1 -0.5
Exposure to tobacco smoke outside home 1.3 1.7 3.2 1.4 -1.8 -0.3 0.7 -1.0 -1.8 -1.2 -1.8 -1.7 -1.3 -1.6 0.0 -0.8 -1.4 -1.8 -0.7 -1.2 -1.7 -1.0 -1.3
Comparative body size at age 10 0.3 0.9 4.5 1.7 0.2 -0.2 1.5 -1.6 0.2 0.4 0.2 0.2 -0.6 -1.5 -1.4 -2.1 0.8 0.1 -0.2 0.1 0.2 0.1 0.3
Number of full brothers 0.9 1.1 4.5 0.5 -0.5 1.5 2.1 -1.3 -0.5 -0.5 -0.5 -0.5 -1.6 -1.0 -2.0 -1.3 0.1 -0.5 -1.4 -0.5 -0.5 -0.4 -0.5
Worry too long after embarrassment 0.0 0.1 0.4 -0.3 -0.2 -0.0 -0.6 -0.1 -0.2 -0.1 -0.2 -0.1 -0.2 0.2 0.1 0.5 -0.4 -0.2 -0.2 0.0 -0.1 -0.2 0.0
Seen a psychiatrist for nerves, anxiety, tension or depression 1.5 1.9 3.6 0.1 -1.6 0.8 0.2 -0.0 -1.6 -1.3 -1.6 -1.6 -1.9 -1.2 1.6 0.7 -1.9 -1.6 -1.4 -1.7 -1.6 -1.4 -1.6
Wheeze or whistling in the chest in last year 0.1 0.2 0.8 0.6 -0.3 0.5 0.2 -0.2 -0.3 -0.1 -0.3 -0.4 -0.6 -0.9 0.0 -0.7 -0.3 -0.4 -0.7 -0.7 -0.4 -0.2 -0.5
Number of children fathered 0.2 0.2 1.9 0.1 0.5 0.3 0.1 -0.1 0.5 0.4 0.5 0.5 1.4 0.1 -0.4 -0.1 -0.1 0.5 0.4 0.5 0.5 0.2 0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 3.0 -0.1 0.5 -1.1 -1.0 0.5 0.5 0.9 0.5 0.6 0.2 0.6 0.7 1.0 1.4 0.5 1.7 0.9 0.6 0.8 0.8
Age at first live birth 0.3 0.5 2.2 1.5 -0.7 0.8 0.5 -0.5 -0.7 -0.1 -0.7 -0.7 0.7 -1.3 0.2 0.3 0.1 -0.7 -0.3 -0.6 -0.7 -0.6 -0.8
Pulse wave peak to peak time 2.2 2.6 5.2 -0.4 1.8 0.7 -0.6 0.4 1.8 2.0 1.8 1.8 1.8 1.1 -0.6 1.0 1.5 1.8 2.1 2.3 1.9 2.1 2.1
Health satisfaction 0.5 0.7 1.7 1.1 -1.0 0.7 0.5 -0.2 -1.0 -0.6 -1.0 -1.0 -0.6 -1.3 0.5 -0.4 -0.6 -1.0 -1.1 -0.9 -0.9 -0.9 -0.7
Shortness of breath walking on level ground 0.6 0.7 1.3 -1.0 1.0 0.6 -0.5 0.7 1.0 0.9 1.0 1.0 1.0 0.5 0.1 0.3 0.9 1.0 0.3 0.9 0.9 1.1 0.9
Qualifications: College or University degree 0.6 1.7 3.6 -1.4 1.3 0.5 -1.6 1.0 1.3 1.0 1.3 1.3 1.4 1.9 0.8 1.5 1.8 1.3 0.8 1.4 1.3 1.1 1.4
Eye problems/disorders: None of the above 0.5 0.6 1.4 -0.1 0.9 1.2 0.2 -0.7 0.9 1.0 0.9 0.9 0.7 -0.0 -0.5 0.4 0.8 0.9 0.5 0.8 0.9 0.9 0.8
Mouth/teeth dental problems: Loose teeth 0.3 0.3 1.0 -0.9 -0.7 0.4 0.3 0.1 -0.7 -1.0 -0.7 -0.6 -0.6 0.2 -0.2 -0.3 -0.6 -0.7 -0.5 -0.4 -0.6 -0.1 -0.5
Emphysema/chronic bronchitis 0.5 0.6 2.2 0.7 -0.8 1.5 0.8 -0.7 -0.8 -0.6 -0.8 -0.7 -0.5 -1.1 -0.1 -0.6 -0.7 -0.8 -1.0 -0.7 -0.7 -0.6 -0.4
Medication for pain relief, constipation, heartburn 0.2 0.3 1.2 0.5 -0.4 -1.1 -0.4 -0.1 -0.4 -0.5 -0.4 -0.4 -0.6 0.5 -0.1 0.6 -0.8 -0.4 0.8 0.1 -0.4 -0.4 -0.4
Neck or shoulder pain in last month 0.2 0.3 1.9 1.0 0.3 1.4 0.6 -0.2 0.3 0.6 0.3 0.3 -0.0 -0.7 -0.1 -0.2 0.9 0.3 -0.4 0.1 0.3 0.1 0.3
Medication: Blood pressure 1.1 2.0 9.0 -1.1 0.9 0.2 -2.4 2.2 0.9 0.9 0.9 0.9 1.2 1.2 3.0 2.3 0.2 0.9 1.4 1.0 1.0 1.0 1.0
Angina (self-reported) 0.7 0.9 1.5 -0.6 1.1 0.7 -0.7 1.1 1.1 1.0 1.1 1.1 0.1 1.0 0.5 1.2 1.2 1.1 0.9 1.0 1.1 1.0 1.1
Migraine (self-reported) 1.2 1.4 3.1 0.8 -1.3 0.5 1.0 -0.7 -1.3 -1.5 -1.3 -1.3 -0.8 -0.8 -0.6 -1.1 -1.5 -1.3 -1.8 -1.3 -1.3 -1.3 -1.3
Medication: Ibuprofen 0.3 0.3 1.1 -0.2 0.6 1.1 0.4 -0.4 0.6 0.9 0.6 0.6 0.9 -0.1 -0.2 -0.0 0.6 0.6 0.1 0.4 0.6 0.9 0.6
Medication: Allopurinol 0.5 0.6 3.1 -0.2 0.4 1.3 1.3 -1.3 0.4 0.3 0.4 0.3 1.2 -0.5 -1.8 -0.8 0.6 0.4 -0.1 0.4 0.3 0.4 0.2
Medication: Omeprazole 0.7 0.8 2.1 -0.8 -0.9 0.4 0.4 -0.2 -0.9 -1.5 -0.9 -0.9 -1.2 -0.1 -0.4 -1.2 -1.0 -0.9 -1.4 -1.0 -0.9 -0.9 -0.8
Medication: Seretide 50 evohaler 0.7 0.9 2.2 0.1 0.9 0.4 -0.6 0.9 0.9 0.9 0.9 0.9 1.3 0.9 -0.1 0.5 0.9 0.9 1.1 1.5 1.0 1.2 1.2
Mean time to correctly identify matches 0.1 0.2 1.1 -0.0 0.2 0.1 -0.4 0.7 0.2 -0.0 0.2 0.2 -0.1 0.2 1.0 -0.2 -1.1 0.2 0.2 0.2 0.3 -0.0 0.5
Heart disease (mother) 2.7 3.3 6.0 -1.3 2.1 -0.7 -2.3 2.4 2.1 1.7 2.1 2.1 1.0 2.4 1.9 1.3 0.7 2.1 2.0 1.5 2.0 1.3 1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 0.9 1.9 0.7 1.1 1.2 -0.5 0.5 1.1 1.3 1.1 1.1 0.5 -0.2 0.7 0.7 1.4 1.1 0.6 1.0 1.1 1.2 1.1
Whole body fat mass 0.0 0.2 1.2 0.8 -0.1 -0.5 0.4 0.2 -0.1 0.1 -0.1 -0.1 0.0 -1.1 0.1 -0.6 0.0 -0.1 -0.6 -0.3 -0.1 -0.1 -0.2
Leg fat mass (right) 0.2 0.6 2.7 1.3 -0.5 -0.2 1.1 -0.5 -0.5 -0.3 -0.5 -0.5 -0.6 -1.6 -0.6 -1.1 -0.3 -0.5 -1.2 -0.7 -0.5 -0.4 -0.6
Arm predicted mass (right) 0.1 0.4 2.0 0.4 -0.4 -0.8 -0.5 0.9 -0.4 -0.3 -0.4 -0.5 -0.5 -0.7 1.4 0.4 0.4 -0.5 -0.8 -0.6 -0.5 -0.2 -0.6
Pulse rate, automated reading 0.6 2.0 5.6 2.3 -0.9 1.0 2.4 -2.4 -0.9 -0.4 -0.9 -0.9 -1.0 -2.3 -1.8 -1.9 0.4 -0.9 -1.1 -0.8 -0.9 -1.1 -0.9
Alcohol intake frequency. 0.3 0.7 4.7 0.5 0.6 -0.3 1.2 -1.2 0.6 1.0 0.6 0.6 -0.4 -0.7 -2.2 -0.9 0.9 0.6 0.3 0.4 0.5 0.4 0.5
Comparative height size at age 10 0.4 2.3 13.6 -1.7 0.6 -0.4 -2.6 2.4 0.6 0.7 0.6 0.7 1.6 1.2 3.7 2.5 1.2 0.6 1.0 0.7 0.7 0.6 0.8
Number of full sisters 3.4 4.1 6.7 1.1 -2.4 -0.8 1.5 -1.4 -2.4 -2.5 -2.4 -2.4 -2.5 -1.4 -1.2 -1.6 -2.6 -2.4 -1.8 -2.1 -2.3 -2.2 -2.3
Suffer from ‘nerves’ 0.8 1.2 3.4 -0.4 -1.3 -0.1 -0.5 0.4 -1.3 -1.2 -1.3 -1.3 -1.3 -0.3 0.7 0.6 -1.8 -1.3 -0.7 -1.2 -1.3 -1.4 -1.4
Overall health rating 0.3 0.7 3.0 1.7 -0.3 1.5 1.0 -0.2 -0.3 0.1 -0.3 -0.3 -0.8 -1.5 -0.2 -1.3 0.6 -0.4 -0.9 -0.5 -0.3 -0.8 -0.2
Chest pain or discomfort 0.4 0.6 2.1 0.8 -0.7 0.8 -0.8 1.0 -0.7 -0.8 -0.7 -0.7 -0.4 -0.1 1.5 0.9 -0.4 -0.7 -0.5 -0.6 -0.7 -1.2 -0.5
Had major operations 0.5 0.6 4.4 -2.1 0.5 -0.4 -1.1 0.9 0.5 0.2 0.5 0.5 0.7 1.2 0.5 0.1 -0.1 0.4 0.1 0.5 0.5 0.8 0.5
Age at last live birth 0.2 0.3 1.4 0.8 0.1 0.1 -0.7 0.8 0.1 0.5 0.1 0.1 1.2 -0.0 0.6 1.2 0.8 0.1 0.6 0.3 0.1 0.6 0.1
Family relationship satisfaction 0.7 0.8 2.5 1.6 -0.7 1.2 1.2 -1.0 -0.7 -0.1 -0.7 -0.7 -1.1 -1.4 -0.6 0.1 0.1 -0.7 -0.9 -0.9 -0.8 -0.8 -0.9
Leg pain on walking 0.2 0.2 1.5 -0.3 -0.5 -0.8 0.3 -0.2 -0.5 -0.5 -0.5 -0.5 -0.2 -0.3 -0.4 -0.3 -1.2 -0.5 0.4 0.1 -0.4 0.2 -0.1
Qualifications: NVQ or HND or HNC or equivalent 0.8 1.0 2.2 -0.4 -1.3 -0.1 -0.1 0.1 -1.3 -1.1 -1.3 -1.3 -0.5 -0.7 0.6 1.0 0.2 -1.3 -1.1 -0.9 -1.3 -1.3 -1.5
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.8 0.9 0.1 0.4 0.3 0.0 0.1 0.2 0.1 0.1 0.2 -0.5 0.3 0.5 0.0 0.1 -0.2 -0.2 0.0 -0.2 -0.4
Illness, injury, bereavement, stress in last 2 years 2.6 3.2 5.0 1.2 -2.2 -0.2 1.4 -1.8 -2.2 -2.0 -2.2 -2.2 -1.1 -1.5 -1.0 -1.0 -1.9 -2.2 -1.6 -1.9 -2.2 -1.9 -2.0
Medication: Aspirin 5.0 6.5 16.1 -3.5 2.4 -0.5 -3.4 4.0 2.4 2.0 2.4 2.4 2.2 3.1 3.1 2.5 1.0 2.3 2.4 2.0 2.4 2.5 2.4
Supplements: Vitamin C 0.2 0.3 1.8 -0.1 0.0 -0.2 1.3 -0.8 0.0 0.4 0.0 -0.0 0.0 -0.8 -0.9 -0.3 0.8 -0.0 -0.5 -0.0 -0.0 0.4 -0.1
Knee pain experienced in last month 1.2 1.8 3.3 0.3 1.6 0.2 -1.1 0.9 1.6 1.8 1.6 1.6 0.8 -0.1 1.5 1.6 1.7 1.6 0.9 1.4 1.6 1.5 1.4
Hypertension (Self-reported) 5.5 15.2 57.5 -3.4 2.5 -1.6 -6.9 7.1 2.5 1.9 2.5 2.5 2.5 4.6 7.6 6.2 0.9 2.4 3.2 2.5 2.5 2.0 2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.6 -0.8 0.4 0.3 -0.5 0.5 0.4 0.1 0.4 0.4 0.2 0.6 0.4 0.1 0.2 0.4 -0.1 0.1 0.4 0.2 0.1
Illnesses of father: Heart disease 4.5 6.2 10.7 -2.0 2.8 -0.5 -3.3 3.1 2.8 2.3 2.8 2.8 1.3 2.6 2.4 2.8 1.3 2.8 2.3 2.6 2.8 2.4 2.6
Illnesses of siblings: Diabetes 0.9 1.1 5.5 1.6 -0.0 0.6 2.3 -1.5 -0.0 0.4 -0.0 -0.1 -1.0 -1.8 -1.8 -0.9 1.1 -0.0 -0.7 -0.3 -0.1 0.1 -0.1
Smoking status: Previous 0.7 1.1 3.0 -0.8 1.1 -0.7 -0.5 1.4 1.1 0.9 1.1 1.1 1.3 1.1 -0.4 0.8 0.6 1.1 1.7 1.2 1.1 1.1 1.1
Forced expiratory volume in 1-second (FEV1), predicted 1.0 2.0 4.5 -1.0 1.4 -0.2 -1.8 2.1 1.4 1.2 1.4 1.4 1.0 1.6 1.3 1.4 1.9 1.4 1.4 1.6 1.4 1.2 1.3
Whole body fat-free mass 0.1 0.5 3.1 0.2 -0.5 -1.0 -1.0 1.2 -0.5 -0.4 -0.5 -0.5 -0.5 -0.4 1.8 0.6 -0.1 -0.6 -0.7 -0.6 -0.5 -0.2 -0.6
Leg fat-free mass (right) 0.1 0.7 2.2 0.5 -0.8 -1.3 -0.7 1.1 -0.8 -0.6 -0.8 -0.8 -0.3 -0.6 1.5 0.2 -0.5 -0.8 -0.7 -0.9 -0.8 -0.5 -0.8
Arm fat percentage (left) 0.0 0.2 1.0 0.8 -0.2 -0.6 0.6 0.0 -0.2 -0.0 -0.2 -0.2 -0.2 -1.0 -0.3 -0.8 -0.1 -0.2 -0.6 -0.3 -0.2 -0.1 -0.2
Average weekly red wine intake 1.0 1.5 2.7 -0.5 1.4 -0.2 -1.5 1.3 1.4 1.5 1.4 1.3 1.1 0.9 1.4 1.6 0.8 1.3 0.9 1.0 1.3 1.2 1.1
Handedness (chirality/laterality): Left-handed 0.6 0.7 3.2 0.5 0.9 -0.6 -0.5 0.8 0.9 1.1 0.9 0.8 0.5 0.2 0.8 1.8 1.1 0.9 0.8 0.9 0.8 0.4 0.7
Mood swings 0.0 0.1 0.6 -0.8 -0.1 0.5 -0.5 0.2 -0.1 -0.2 -0.1 -0.1 -0.1 0.4 0.2 -0.1 0.4 -0.1 -0.0 0.1 -0.1 0.0 0.1
Loneliness, isolation 1.5 2.1 6.8 0.8 -1.4 -0.1 1.8 -1.3 -1.4 -1.2 -1.4 -1.4 -1.5 -1.4 -1.5 -2.6 -1.4 -1.5 -1.6 -1.4 -1.4 -1.0 -1.2
Long-standing illness, disability or infirmity 0.8 1.3 2.5 -0.9 1.2 -0.1 -0.8 1.2 1.2 1.4 1.2 1.2 1.1 0.7 0.5 0.7 1.2 1.2 1.0 1.4 1.2 1.6 1.4
Ever had bowel cancer screening 0.3 0.3 1.1 0.3 0.6 0.4 -0.5 0.2 0.6 0.9 0.6 0.6 1.0 -0.2 1.0 0.7 0.3 0.6 0.3 0.3 0.6 0.0 0.4
Diabetes diagnosed by doctor 1.0 1.6 3.4 -1.0 1.5 0.4 -0.7 0.9 1.5 1.4 1.5 1.5 1.1 1.0 0.6 1.0 0.7 1.5 1.2 1.7 1.6 1.4 1.8
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 2.2 0.5 0.4 -0.6 0.5 -0.2 0.4 0.3 0.4 0.4 0.2 0.2 -1.5 -0.7 1.2 0.4 0.0 0.3 0.4 0.4 0.2
Friendships satisfaction 0.2 0.3 1.4 1.1 0.0 -0.4 -0.5 1.2 0.0 0.1 0.0 0.0 0.2 0.4 1.0 -0.2 0.9 -0.0 0.1 -0.1 0.0 -0.2 0.2
Qualifications: nursing, teaching 0.4 0.6 2.0 0.2 0.8 -0.2 -0.9 0.8 0.8 0.8 0.8 0.8 0.6 0.8 0.1 1.1 0.6 0.8 1.4 1.0 0.8 0.1 0.9
Commuting to job workplace: Walk 0.4 0.4 1.0 0.0 -1.0 -0.5 -0.1 0.2 -1.0 -0.6 -1.0 -0.9 -0.2 -0.1 0.6 0.2 -0.8 -1.0 0.5 -0.3 -0.9 -0.4 -0.4
Eye problems/disorders: Cataract 1.2 1.4 4.8 -0.1 -1.4 -2.2 0.2 0.4 -1.4 -1.4 -1.4 -1.4 -0.8 0.3 0.0 -1.1 -2.1 -1.4 -0.1 -1.3 -1.3 -1.1 -1.2
Mouth/teeth dental problems: Mouth ulcers 1.3 2.0 5.2 -0.8 1.2 0.1 -1.7 2.0 1.2 1.1 1.2 1.2 1.6 1.9 1.2 1.4 0.3 1.2 2.3 1.7 1.3 1.4 1.8
Medication for cholesterol 5.1 7.7 21.9 3.1 -2.1 2.1 4.3 -4.7 -2.1 -1.6 -2.1 -2.1 -2.0 -3.8 -3.9 -3.3 -1.1 -2.1 -2.7 -2.4 -2.2 -2.2 -2.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.6 1.8 4.8 -0.5 -1.1 1.7 1.4 -1.7 -1.1 -1.2 -1.1 -1.1 -1.7 -1.1 -1.5 -1.8 -1.4 -1.1 -2.2 -1.1 -1.1 -0.9 -1.2
Back pain experienced in last month 0.3 0.4 1.8 1.3 0.3 -0.2 1.0 -0.7 0.3 1.1 0.3 0.3 0.3 -1.1 -0.4 -0.2 0.6 0.3 0.3 -0.2 0.3 0.1 0.2
Mineral and other dietary supplements 0.5 0.6 1.7 -0.5 1.0 0.7 0.1 0.2 1.0 0.7 1.0 1.0 -0.5 0.4 -0.5 0.3 0.2 1.0 0.9 1.3 1.0 0.6 1.2
Breast cancer (self-reported) 0.1 0.2 0.7 -0.2 0.3 -0.3 -0.4 0.1 0.3 0.5 0.3 0.3 0.4 0.4 0.7 0.4 0.6 0.3 0.1 0.2 0.3 0.9 0.3
Asthma (self-reported) 0.1 0.2 0.7 0.8 -0.5 -0.5 -0.4 0.9 -0.5 -0.5 -0.5 -0.5 -0.2 0.1 -0.1 -0.1 -0.1 -0.5 -0.1 -0.4 -0.5 -0.4 -0.5
Osteoporosis (self-reported) 0.9 1.1 2.5 -0.1 1.1 1.0 -0.8 0.7 1.1 1.5 1.1 1.1 0.8 0.1 1.6 1.1 0.5 1.1 0.6 1.2 1.1 1.1 1.3
Osteoarthritis (self-reported) 0.2 0.3 2.3 0.2 -0.3 -1.5 -0.2 0.4 -0.3 0.0 -0.3 -0.3 0.1 -0.2 1.0 0.5 -0.5 -0.3 -0.2 -0.6 -0.3 -0.3 -0.6
Medication: Aspirin 4.1 5.3 11.7 -3.2 2.2 -0.1 -2.8 3.4 2.2 1.8 2.2 2.3 2.0 2.8 2.6 2.1 1.1 2.2 2.2 1.9 2.3 2.3 2.3
Medication: Gliclazide 0.4 0.4 1.1 -0.5 0.8 -0.3 -0.5 0.4 0.8 0.7 0.8 0.8 0.4 0.6 0.4 1.1 0.7 0.8 0.4 0.5 0.7 0.3 0.5
Illnesses of father: None of the above (group 1) 2.2 2.8 5.9 0.7 -1.7 1.1 2.2 -2.0 -1.7 -1.8 -1.7 -1.7 -0.8 -1.7 -1.6 -1.7 -0.9 -1.7 -2.4 -1.7 -1.7 -1.7 -1.8
Smoking status: Current 0.7 1.1 2.7 -0.9 1.3 1.1 0.0 -0.3 1.3 1.1 1.3 1.3 0.4 0.0 -0.9 -0.8 0.7 1.3 0.3 1.0 1.3 1.6 1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.3 1.5 -0.3 0.0 -0.0 -1.2 0.6 0.0 -0.3 0.0 0.0 -0.4 1.0 1.0 0.4 0.8 0.0 -0.0 0.1 0.0 -0.1 -0.1
Whole body water mass 0.1 0.6 2.9 0.2 -0.7 -1.0 -0.8 1.1 -0.7 -0.5 -0.7 -0.7 -0.7 -0.6 1.7 0.5 -0.1 -0.7 -0.8 -0.8 -0.7 -0.3 -0.8
Leg predicted mass (right) 0.1 0.6 2.0 0.6 -0.8 -1.3 -0.7 1.1 -0.8 -0.6 -0.8 -0.8 -0.4 -0.6 1.4 0.1 -0.5 -0.8 -0.7 -0.9 -0.8 -0.5 -0.8
Arm fat mass (left) 0.0 0.2 0.8 0.7 -0.3 -0.9 0.3 0.3 -0.3 -0.2 -0.3 -0.3 -0.2 -0.8 -0.1 -0.8 -0.1 -0.3 -0.7 -0.4 -0.3 -0.1 -0.3
Number of self-reported non-cancer illnesses 3.7 6.5 12.2 -2.0 2.8 0.4 -3.3 3.5 2.8 2.4 2.8 2.8 1.5 2.4 3.0 2.7 1.6 2.7 1.8 2.5 2.8 2.5 2.8
Average weekly champagne plus white wine intake 0.5 0.7 1.4 0.3 -1.0 -0.3 -0.8 1.1 -1.0 -1.2 -1.0 -1.0 0.0 0.7 1.1 1.0 -0.5 -1.0 -0.1 -0.6 -0.9 -0.8 -0.6
Miserableness 1.0 1.8 5.6 1.4 -1.1 0.9 1.8 -1.7 -1.1 -0.9 -1.1 -1.1 -1.2 -1.8 -1.5 -2.4 -0.4 -1.1 -1.6 -1.4 -1.1 -1.2 -1.1
Guilty feelings 0.3 0.5 3.3 -0.6 0.5 0.6 0.5 -0.5 0.5 0.4 0.5 0.5 0.4 0.2 -1.8 -1.0 -1.0 0.5 0.3 0.7 0.5 0.3 0.7
Wears glasses or contact lenses 0.2 0.2 1.0 -0.8 0.4 -0.4 0.3 -0.2 0.4 0.3 0.4 0.4 -0.1 0.3 -1.0 -0.8 -0.1 0.5 -0.0 -0.1 0.4 0.4 0.3
Ever taken oral contraceptive pill 0.2 0.3 1.3 -0.6 -0.2 -1.1 -0.5 1.1 -0.2 -0.4 -0.2 -0.2 0.4 0.7 0.1 0.4 0.4 -0.2 0.8 -0.0 -0.2 0.1 -0.1
Hearing aid user 0.3 0.3 1.6 -1.3 -0.1 0.1 1.2 -0.9 -0.1 -0.1 -0.1 -0.1 0.2 -0.2 -1.0 -0.9 0.1 -0.1 0.6 0.3 -0.0 0.4 0.2
Mother’s age at death 0.5 0.6 4.0 0.1 0.5 -1.3 0.7 -0.9 0.5 0.7 0.5 0.5 0.9 -0.1 -2.0 -0.2 -0.2 0.5 1.2 0.4 0.5 0.5 0.3
Financial situation satisfaction 0.2 0.2 1.7 1.2 0.0 0.2 0.5 0.0 0.0 0.2 0.0 0.0 -0.1 -0.5 -0.7 -1.3 0.5 -0.0 -0.2 0.1 0.0 0.1 0.1
Tinnitus: Yes, now most or all of the time 0.3 0.4 1.8 -0.3 0.5 -0.1 -0.9 0.9 0.5 0.5 0.5 0.5 0.0 0.4 1.4 0.6 0.1 0.5 0.8 0.4 0.5 0.4 0.5
Commuting to job workplace: Public transport 0.4 0.4 1.5 -1.1 -0.5 -1.0 -1.2 0.7 -0.5 -0.9 -0.5 -0.4 -0.2 0.9 0.6 0.1 -1.0 -0.5 -0.4 -0.1 -0.4 0.1 -0.2
Eye problems/disorders: Glaucoma 1.4 1.7 2.8 0.9 -1.5 0.1 1.1 -1.4 -1.5 -1.5 -1.5 -1.5 -0.9 -1.0 -1.6 -1.7 -0.9 -1.5 -1.2 -1.2 -1.5 -1.1 -1.3
Medication: Blood pressure 10.2 19.4 57.8 -4.0 3.3 -1.9 -7.1 7.6 3.3 2.6 3.3 3.4 3.5 5.3 7.3 5.6 2.4 3.3 4.0 3.6 3.4 3.4 3.8
Pain type(s) experienced in last month: Hip pain 0.3 0.4 1.5 1.1 0.1 -1.2 -0.8 1.0 0.1 0.4 0.1 0.1 -0.1 0.4 1.0 0.6 0.8 0.1 1.0 0.1 0.2 0.3 0.3
Supplements: Fish oil (including cod liver oil) 0.4 0.6 1.3 1.2 -0.9 -0.6 0.5 -0.4 -0.9 -0.6 -0.9 -0.9 0.3 -0.7 -0.4 -0.8 -0.4 -0.9 -0.7 -1.0 -0.9 -0.8 -0.9
High cholesterol (Self-reported) 1.1 2.0 3.3 -1.4 1.5 -0.4 -1.8 1.8 1.5 1.4 1.5 1.5 0.9 1.6 1.8 1.2 1.3 1.5 1.0 1.1 1.5 1.4 1.3
Medication: Bendroflumethiazide 2.6 3.9 20.5 -2.4 0.8 -1.1 -3.6 3.7 0.8 0.6 0.8 0.9 0.9 2.2 4.5 2.9 0.2 0.8 1.5 1.0 0.9 1.0 1.0
Medication: Paracetamol 0.4 0.6 2.6 1.0 0.7 -0.1 1.0 -1.0 0.7 1.0 0.7 0.7 0.8 -0.4 -1.4 -0.4 1.6 0.7 -0.0 0.3 0.7 0.2 0.6
Medication: Lisinopril 1.0 1.3 5.4 -1.8 0.5 0.6 -2.2 2.0 0.5 -0.0 0.5 0.5 1.0 1.6 2.3 1.2 -0.3 0.5 0.4 0.7 0.6 0.7 0.7
Medication: Atorvastatin 0.1 0.1 0.4 -0.3 -0.1 -0.0 -0.2 0.6 -0.1 -0.3 -0.1 -0.1 -0.5 0.4 -0.6 -0.3 0.2 -0.1 0.2 -0.0 -0.1 0.2 0.0
Illnesses of father: High blood pressure 3.0 3.7 10.1 -1.4 1.6 0.3 -3.1 2.6 1.6 1.6 1.6 1.7 1.0 2.1 2.6 3.2 1.1 1.7 1.8 2.0 1.7 1.6 1.9
Alcohol drinker status: Never 5.1 6.2 11.6 -0.8 2.9 -0.4 -2.2 1.8 2.9 3.3 2.9 2.9 1.3 1.7 1.3 3.2 3.4 2.9 2.5 2.7 2.8 2.1 2.8
Ever smoked 2.4 4.2 5.7 -2.0 2.4 0.6 -1.9 1.9 2.4 1.7 2.4 2.4 2.0 2.3 0.6 2.0 1.6 2.4 2.1 2.3 2.3 2.2 2.2
Basal metabolic rate 0.1 0.5 2.3 0.3 -0.6 -0.8 -0.6 1.0 -0.6 -0.5 -0.6 -0.6 -0.6 -0.7 1.5 0.3 -0.1 -0.6 -0.9 -0.7 -0.6 -0.3 -0.7
Leg fat percentage (left) 0.2 0.7 3.0 1.5 -0.1 -0.2 1.6 -1.0 -0.1 0.3 -0.1 -0.1 -0.3 -1.7 -1.5 -1.4 0.1 -0.1 -0.6 -0.3 -0.1 -0.1 -0.2
Arm fat-free mass (left) 0.1 0.5 1.1 0.4 -0.7 -0.9 -0.2 0.5 -0.7 -0.6 -0.7 -0.7 -1.0 -0.9 0.9 -0.1 0.1 -0.8 -1.1 -0.8 -0.8 -0.4 -0.9
Number of operations (self-reported) 0.1 0.2 0.7 -0.3 0.4 0.8 0.3 0.1 0.4 0.6 0.4 0.4 -0.5 -0.4 0.1 0.4 0.5 0.4 -0.5 0.2 0.4 0.2 0.3
Average weekly beer plus cider intake 0.4 0.6 3.8 -0.5 -0.3 0.0 -0.6 1.5 -0.3 -0.4 -0.3 -0.3 -1.1 -0.1 1.6 0.2 -1.9 -0.3 -0.3 -0.5 -0.3 -0.5 -0.2
Irritability 0.3 0.5 3.6 0.1 -0.1 -0.6 -1.1 1.5 -0.1 -0.2 -0.1 -0.1 0.2 0.9 1.9 0.2 -0.3 -0.1 0.6 0.0 -0.0 -0.4 -0.0
Risk taking 1.1 1.6 4.0 1.3 -1.4 -1.3 0.9 -0.5 -1.4 -1.2 -1.4 -1.4 -0.6 -1.1 -0.5 -0.6 -1.0 -1.4 -1.2 -1.5 -1.5 -2.0 -1.5
Ever had prostate specific antigen (PSA) test 0.2 0.3 1.3 1.1 -0.3 -0.5 -0.1 0.1 -0.3 0.3 -0.3 -0.3 -0.6 -0.8 0.6 0.9 0.1 -0.3 -0.3 -0.5 -0.3 -0.8 -0.6
Fractured/broken bones in last 5 years 0.1 0.2 1.1 0.2 0.3 0.5 -0.2 0.4 0.3 0.1 0.3 0.3 -0.2 0.2 1.1 0.8 0.6 0.3 0.7 0.4 0.2 0.1 0.2
Age started oral contraceptive pill 0.2 0.3 0.7 0.2 -0.6 -0.3 0.4 -0.8 -0.6 -0.5 -0.6 -0.6 -0.5 -0.7 0.2 -0.1 -0.5 -0.6 -0.5 -0.6 -0.6 -0.5 -0.6
Diastolic blood pressure, automated reading 3.2 10.0 66.4 -0.8 0.4 -1.5 -5.8 6.8 0.4 0.2 0.4 0.4 1.2 2.6 8.2 5.8 -0.2 0.4 2.0 1.0 0.5 0.1 1.0
Ever depressed for a whole week 0.4 0.5 2.2 -1.4 -0.1 -1.5 -1.1 1.5 -0.1 -0.4 -0.1 -0.1 -0.4 1.2 0.5 -0.3 -1.0 -0.1 0.2 -0.3 -0.2 0.0 -0.2
Unable to work because of sickness or disability 0.7 1.0 5.1 0.8 -0.1 2.3 2.1 -1.4 -0.1 0.6 -0.1 -0.0 -0.3 -1.8 -0.7 -0.7 1.3 -0.1 -0.5 0.2 0.0 0.3 0.5
Commuting to job workplace: Cycle 0.4 0.5 1.9 -1.3 0.5 -1.2 -0.3 1.2 0.5 0.1 0.5 0.5 0.9 1.4 -0.5 0.2 0.2 0.5 0.5 0.7 0.5 0.4 0.6
Myopia 1.3 1.9 5.3 0.2 1.6 2.3 0.1 -0.5 1.6 2.0 1.6 1.6 1.7 -0.3 -0.2 0.9 1.8 1.6 0.3 1.3 1.5 1.4 1.4
Vascular/heart problems diagnosed by doctor 5.0 13.8 49.0 2.9 -2.6 1.3 6.3 -6.6 -2.6 -2.1 -2.6 -2.6 -2.4 -4.2 -7.0 -5.9 -1.3 -2.5 -3.2 -2.6 -2.6 -2.1 -2.8
Cholesterol lowering medication 0.6 0.8 3.2 -0.6 0.5 -1.3 -1.2 1.8 0.5 0.4 0.5 0.5 0.7 1.1 1.8 0.9 0.8 0.5 0.7 0.5 0.5 0.4 0.7
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 1.5 0.4 -0.6 0.1 0.3 0.0 -0.6 -0.7 -0.6 -0.6 -1.1 -0.6 0.3 -0.7 -0.2 -0.6 -1.2 -0.9 -0.6 -0.7 -0.6
Pain experienced in last month 0.7 1.2 7.2 -2.7 0.8 -1.0 -1.3 1.2 0.8 -0.1 0.8 0.8 0.7 2.2 0.5 0.6 0.4 0.8 0.9 1.0 0.8 1.0 0.9
Supplements: Calcium 0.3 0.3 1.6 0.7 0.0 0.6 0.9 -0.6 0.0 0.5 0.0 0.0 0.2 -0.7 0.3 0.8 1.3 0.0 -0.3 0.3 0.1 0.6 0.3
Basal cell carcinoma (self-reported) 0.8 1.0 2.2 0.4 -0.9 0.4 0.1 0.0 -0.9 -1.1 -0.9 -1.0 -1.3 -0.2 0.5 0.1 -1.4 -0.9 -1.4 -1.5 -1.0 -1.5 -1.3
Heart attack/myocardial infarction (self-reported) 1.8 2.3 9.5 -1.4 1.1 0.3 -2.4 2.8 1.1 0.8 1.1 1.1 0.5 1.5 3.1 2.0 0.6 1.1 1.1 1.1 1.1 1.2 1.3
Deep venous thrombosis (DVT) (self-reported) 0.7 1.0 4.5 0.3 -0.6 1.2 2.1 -1.6 -0.6 -0.4 -0.6 -0.6 -0.5 -1.5 -1.3 -0.8 0.1 -0.6 -1.5 -0.6 -0.6 -0.8 -0.4
Heart disease (siblings) 0.9 1.1 3.8 -0.0 0.8 -1.1 -1.5 1.9 0.8 0.6 0.8 0.8 0.7 1.1 1.8 1.3 0.7 0.8 1.2 0.8 0.8 0.5 1.0
Alcohol drinker status: Previous 1.5 1.7 3.1 -0.7 1.6 0.8 0.3 0.0 1.6 1.7 1.6 1.6 1.1 0.5 -1.1 -0.5 1.8 1.6 1.2 1.4 1.6 1.4 1.5
Pack years of smoking 0.5 0.7 3.6 1.9 -0.5 1.0 1.0 -0.8 -0.5 -0.2 -0.5 -0.5 -0.2 -1.3 -0.6 -1.1 -1.3 -0.5 -0.8 -0.5 -0.5 -0.6 -0.2
Impedance of whole body 0.2 1.1 2.6 -1.1 1.1 1.6 -0.8 0.7 1.1 0.9 1.1 1.0 1.4 1.1 0.4 1.6 1.2 1.1 0.9 1.1 1.0 0.3 0.7
Leg fat mass (left) 0.2 0.7 3.1 1.4 -0.7 -0.5 1.1 -0.5 -0.7 -0.4 -0.7 -0.7 -0.6 -1.8 -0.6 -1.2 -0.4 -0.7 -1.2 -0.8 -0.7 -0.5 -0.7
Arm predicted mass (left) 0.1 0.3 1.1 0.2 -0.4 -1.0 -0.4 0.8 -0.4 -0.4 -0.4 -0.5 -0.7 -0.6 1.0 -0.0 0.2 -0.5 -0.8 -0.5 -0.5 -0.1 -0.6