Best TWAS P=2.1e-08 · Best GWAS P=8.6e-08 conditioned to 0.276
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | CCNT2 | 0.12 | 0.11 | lasso | 2 | 0.10 | 9.8e-13 | -5.2 | -5.2 | 1.7e-07 | 0.90 | 0.02 | 0.98 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | LOC100129961 | 0.17 | 0.14 | enet | 9 | 0.14 | 2.6e-17 | 5.0 | 5.6 | 2.1e-08 | -0.85 | 0.10 | 0.90 | TRUE |
3 | GTEx | Artery Aorta | CCNT2 | 0.12 | 0.12 | lasso | 3 | 0.11 | 1.9e-06 | -5.2 | -5.2 | 1.5e-07 | 0.90 | 0.02 | 0.97 | FALSE |
4 | GTEx | Nerve Tibial | AC016725.4 | 0.15 | 0.06 | lasso | 6 | 0.02 | 8.1e-03 | -5.2 | 5.2 | 2.1e-07 | -0.93 | 0.07 | 0.93 | FALSE |
5 | GTEx | Testis | CCNT2 | 0.31 | 0.26 | lasso | 6 | 0.26 | 9.3e-12 | -5.3 | -5.2 | 2.1e-07 | 0.99 | 0.02 | 0.98 | FALSE |
6 | GTEx | Testis | AC016725.4 | 0.18 | 0.09 | lasso | 6 | 0.09 | 6.3e-05 | 5.0 | -5.1 | 3.0e-07 | 0.63 | 0.05 | 0.94 | FALSE |
7 | GTEx | Thyroid | CCNT2 | 0.09 | 0.10 | lasso | 2 | 0.09 | 1.8e-07 | -5.2 | -5.3 | 1.2e-07 | 0.98 | 0.03 | 0.97 | FALSE |
8 | ROSMAP | Brain Pre-frontal Cortex | CCNT2 | 0.06 | 0.03 | enet | 27 | 0.05 | 1.6e-06 | -5.3 | -5.6 | 2.3e-08 | 0.85 | 0.03 | 0.97 | FALSE |
9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ACMSD | 0.04 | 0.01 | blup | 46 | 0.02 | 2.2e-03 | -5.2 | -5.5 | 4.7e-08 | 0.89 | 0.02 | 0.85 | FALSE |