Best TWAS P=1.91e-08 · Best GWAS P=7.12e-08 conditioned to 0.00287
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Nerve Tibial | COL21A1 | 0.26 | 0.11 | lasso | 10 | 0.15 | 9.7e-11 | 5.4 | -5.3 | 1.1e-07 | -0.94 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Skin Sun Exposed Lower leg | COL21A1 | 0.11 | 0.07 | lasso | 14 | 0.05 | 7.7e-05 | 5.0 | -5.6 | 1.9e-08 | -0.50 | 0.03 | 0.96 | TRUE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | COL21A1 | 0.22 | 0.34 | lasso | 7 | 0.33 | 8.9e-71 | 5.4 | -5.4 | 6.8e-08 | -0.98 | 0.00 | 1.00 | FALSE |
| 4 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | COL21A1 | 0.41 | 0.55 | lasso | 5 | 0.55 | 2.7e-74 | 5.4 | -5.4 | 8.4e-08 | -0.98 | 0.00 | 1.00 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | COL21A1 | 0.09 | 0.01 | blup | 245 | 0.02 | 1.5e-02 | 5.4 | -5.5 | 3.5e-08 | -0.81 | 0.01 | 0.90 | FALSE |
| 6 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | COL21A1 | 0.39 | 0.39 | lasso | 3 | 0.37 | 1.5e-15 | 5.4 | -5.3 | 9.9e-08 | -0.98 | 0.00 | 0.99 | FALSE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | COL21A1 | 0.29 | 0.40 | lasso | 8 | 0.40 | 7.3e-41 | 5.4 | -5.5 | 4.3e-08 | -0.98 | 0.00 | 1.00 | FALSE |