Best TWAS P=4.9e-12 · Best GWAS P=2.79e-12 conditioned to 0.135
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | FHL5 | 0.11 | 0.00 | lasso | 4 | -0.01 | 8.3e-01 | 7.0 | -5.2 | 1.7e-07 | -0.63 | 0.03 | 0.53 | FALSE |
| 2 | GTEx | Artery Tibial | UFL1 | 0.08 | 0.05 | lasso | 4 | 0.04 | 7.9e-04 | 6.4 | 6.3 | 2.1e-10 | 0.93 | 0.06 | 0.90 | FALSE |
| 3 | GTEx | Nerve Tibial | UFL1 | 0.09 | 0.11 | lasso | 8 | 0.08 | 2.8e-06 | 6.5 | 6.4 | 1.5e-10 | 0.89 | 0.09 | 0.91 | FALSE |
| 4 | GTEx | Pancreas | UFL1 | 0.08 | 0.11 | enet | 7 | 0.09 | 1.1e-04 | 6.0 | 6.2 | 7.4e-10 | 0.89 | 0.07 | 0.85 | FALSE |
| 5 | GTEx | Thyroid | UFL1 | 0.06 | 0.00 | lasso | 2 | 0.00 | 6.6e-01 | 6.5 | 6.2 | 7.5e-10 | 0.88 | 0.06 | 0.70 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | FHL5 | 0.04 | 0.03 | bslmm | 444 | 0.02 | 2.9e-03 | 6.0 | -6.0 | 2.6e-09 | -0.79 | 0.09 | 0.87 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Adenocarcinoma | FHL5 | 0.03 | 0.02 | blup | 55 | 0.01 | 7.1e-03 | 6.4 | -6.9 | 4.9e-12 | -0.93 | 0.01 | 0.84 | TRUE |
| 8 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | FHL5 | 0.03 | 0.03 | enet | 3 | 0.02 | 1.9e-03 | 7.0 | -6.6 | 4.3e-11 | -0.96 | 0.00 | 0.92 | FALSE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | FHL5 | 0.07 | 0.00 | blup | 55 | 0.01 | 4.8e-02 | 6.7 | -6.0 | 2.7e-09 | -0.78 | 0.01 | 0.48 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | KIAA0776 | 0.05 | 0.07 | lasso | 2 | 0.06 | 1.8e-06 | 6.4 | 6.3 | 2.8e-10 | 0.89 | 0.06 | 0.94 | FALSE |