Best TWAS P=1.44e-14 · Best GWAS P=3.56e-10 conditioned to 0.0779
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | GOPC | 0.11 | 0.09 | enet | 13 | 0.12 | 4.7e-07 | 5.5 | -5.6 | 2.3e-08 | -0.82 | 0.03 | 0.96 | FALSE |
| 2 | GTEx | Artery Tibial | GOPC | 0.11 | 0.08 | lasso | 4 | 0.09 | 9.0e-08 | 4.5 | -5.7 | 1.4e-08 | -0.81 | 0.10 | 0.90 | FALSE |
| 3 | GTEx | Breast Mammary Tissue | DCBLD1 | 0.10 | 0.02 | lasso | 4 | 0.03 | 1.1e-02 | 5.4 | -6.0 | 1.6e-09 | -0.82 | 0.02 | 0.86 | FALSE |
| 4 | GTEx | Muscle Skeletal | NUS1 | 0.09 | 0.04 | enet | 14 | 0.08 | 1.1e-08 | -4.0 | -5.9 | 4.6e-09 | -0.57 | 0.88 | 0.07 | FALSE |
| 5 | GTEx | Nerve Tibial | GOPC | 0.12 | 0.06 | enet | 17 | 0.06 | 3.7e-05 | 6.1 | -6.1 | 8.4e-10 | -0.93 | 0.01 | 0.99 | FALSE |
| 6 | GTEx | Thyroid | GOPC | 0.11 | 0.02 | enet | 23 | 0.02 | 1.6e-02 | 6.1 | -7.7 | 1.4e-14 | -0.64 | 0.02 | 0.97 | TRUE |
| 7 | GTEx | Whole Blood | DCBLD1 | 0.16 | 0.09 | lasso | 7 | 0.09 | 7.7e-09 | -3.3 | 5.5 | 4.6e-08 | 0.58 | 0.82 | 0.18 | FALSE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | GOPC | 0.13 | 0.16 | enet | 21 | 0.16 | 1.5e-19 | 3.5 | 5.6 | 2.7e-08 | 0.79 | 0.50 | 0.50 | FALSE |
| 9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | GOPC | 0.02 | 0.02 | lasso | 1 | 0.02 | 2.1e-04 | 5.4 | -5.4 | 8.0e-08 | -0.85 | 0.20 | 0.66 | FALSE |