Best TWAS P=1.29e-11 · Best GWAS P=7.46e-10 conditioned to 0.0329
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | NOV | 0.06 | 0.02 | enet | 8 | 0.05 | 1.5e-06 | 4.5 | 5.3 | 9.8e-08 | 0.61 | 0.06 | 0.94 | FALSE |
| 2 | GTEx | Artery Aorta | NOV | 0.12 | 0.05 | enet | 18 | 0.04 | 3.7e-03 | 6.1 | 6.6 | 5.4e-11 | 0.86 | 0.02 | 0.89 | FALSE |
| 3 | GTEx | Colon Sigmoid | NOV | 0.15 | 0.16 | lasso | 4 | 0.15 | 6.6e-06 | 6.0 | 6.0 | 1.6e-09 | 0.71 | 0.03 | 0.96 | FALSE |
| 4 | GTEx | Esophagus Muscularis | NOV | 0.11 | 0.03 | enet | 19 | 0.05 | 3.9e-04 | 6.0 | 5.2 | 1.9e-07 | 0.61 | 0.06 | 0.89 | FALSE |
| 5 | GTEx | Lung | NOV | 0.06 | 0.02 | enet | 23 | 0.03 | 2.5e-03 | 3.9 | 5.7 | 1.3e-08 | 0.76 | 0.03 | 0.92 | FALSE |
| 6 | GTEx | Skin Sun Exposed Lower leg | NOV | 0.11 | 0.03 | lasso | 7 | 0.04 | 1.4e-04 | 5.9 | 5.6 | 2.4e-08 | 0.66 | 0.07 | 0.92 | FALSE |
| 7 | NTR | Blood | NOV | 0.02 | 0.01 | bslmm | 481 | 0.01 | 1.7e-04 | 6.1 | 6.8 | 1.3e-11 | 0.68 | 0.03 | 0.96 | TRUE |
| 8 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | NOV | 0.03 | 0.00 | blup | 42 | 0.01 | 5.3e-02 | 5.9 | 6.0 | 1.7e-09 | 0.67 | 0.02 | 0.78 | FALSE |
| 9 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | NOV | 0.11 | 0.02 | enet | 15 | 0.05 | 2.9e-03 | 5.9 | 5.5 | 3.3e-08 | 0.59 | 0.02 | 0.56 | FALSE |
| 10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NOV | 0.04 | 0.05 | blup | 42 | 0.05 | 8.7e-06 | 6.1 | 5.8 | 7.5e-09 | 0.71 | 0.02 | 0.98 | FALSE |