Hub : Genes

NOV

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0620 0.0220 3.9e-05 0.025 0.041 0.048 0.042 0.046 4.4e-04 7.7e-06 1.5e-06 7.3e-06 2.7e-06
2 GTEx Artery Aorta 0.1160 0.0520 7.0e-03 0.045 NA 0.038 NA 0.028 1.6e-03 NA 3.7e-03 NA 1.1e-02
3 GTEx Artery Tibial 0.0920 0.0367 1.8e-03 0.005 NA 0.001 NA 0.000 1.2e-01 NA 2.7e-01 NA 3.5e-01
4 GTEx Brain Cerebellar Hemisphere 0.3750 0.0930 1.7e-04 0.097 NA 0.195 NA 0.180 1.9e-03 NA 9.9e-06 NA 2.3e-05
5 GTEx Cells Transformed fibroblasts 0.1020 0.0350 9.9e-05 0.038 NA 0.027 NA 0.025 7.5e-04 NA 3.7e-03 NA 5.2e-03
6 GTEx Colon Sigmoid 0.1550 0.0570 1.8e-03 0.160 NA 0.140 NA 0.148 2.7e-06 NA 1.2e-05 NA 6.7e-06
7 GTEx Esophagus Muscularis 0.1140 0.0450 8.8e-04 0.034 NA 0.053 NA 0.039 3.7e-03 NA 3.9e-04 NA 2.1e-03
8 GTEx Lung 0.0604 0.0262 6.3e-03 0.019 NA 0.029 NA 0.020 1.2e-02 NA 2.5e-03 NA 1.1e-02
9 GTEx Skin Sun Exposed Lower leg 0.1140 0.0380 1.0e-04 0.028 NA 0.044 NA 0.044 2.1e-03 NA 1.4e-04 NA 1.4e-04
10 NTR Blood 0.0221 0.0095 8.7e-04 0.014 0.010 0.003 0.010 0.009 2.3e-05 2.6e-04 2.9e-02 1.7e-04 3.7e-04
11 ROSMAP Brain Pre-frontal Cortex 0.1017 0.0319 8.1e-07 0.017 0.064 0.059 0.067 0.062 2.5e-03 1.2e-08 4.6e-08 5.7e-09 2.2e-08
12 TCGA Bladder Urothelial Carcinoma 0.0300 0.0200 7.9e-03 0.005 0.009 0.005 NA 0.004 1.1e-01 5.3e-02 1.0e-01 NA 1.3e-01
13 TCGA Colon Adenocarcinoma 0.3090 0.1150 3.0e-06 0.101 0.105 0.099 NA 0.104 1.8e-06 1.2e-06 2.4e-06 NA 1.4e-06
14 TCGA Kidney Renal Clear Cell Carcinoma 0.0617 0.0322 5.3e-04 0.001 0.027 0.017 NA 0.008 2.1e-01 4.3e-04 4.5e-03 NA 4.1e-02
15 TCGA Brain Lower Grade Glioma 0.1506 0.0617 4.3e-05 0.007 0.039 0.044 NA 0.029 4.3e-02 2.7e-05 8.0e-06 NA 3.0e-04
16 TCGA Pancreatic Adenocarcinoma 0.1070 0.0840 6.7e-03 0.018 0.043 0.053 NA 0.031 5.6e-02 6.9e-03 2.9e-03 NA 1.9e-02
17 TCGA Prostate Adenocarcinoma 0.0440 0.0221 1.3e-05 0.047 0.048 0.035 NA 0.039 1.2e-05 8.7e-06 1.4e-04 NA 5.2e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
Bipolar Disorder (2018) 0.9 1.4 2.8 1.2 -0.2 -0.6 1.3 1.6 1.4 0.7 0.9 0.7 1.4 -1.1 1.3 1.7 0.7 1.0 1.7 1.4
Bipolar Disorder or Schizophrenia 0.1 0.2 1.2 0.3 -0.8 -0.3 -0.0 0.9 -0.1 0.0 0.4 -0.6 0.0 -1.1 -0.1 0.4 -0.0 -0.0 0.4 0.1
Depressed Affect (Nagel 2018) 0.3 0.5 2.0 -0.1 0.0 0.4 -1.4 0.3 0.1 -0.5 -0.2 -0.7 -1.4 0.9 -0.4 -0.3 1.3 1.1 -0.4 0.0
Depression (Nagel 2018) 0.5 0.8 3.1 -0.3 -1.5 -1.4 -0.1 0.2 -0.1 -0.5 -0.4 -0.9 -0.8 0.6 -0.8 -0.5 1.8 1.1 -1.4 0.1
Intelligence (Savage-Jansen 2018) 0.3 1.0 6.6 0.6 0.6 -0.1 1.5 1.1 0.8 1.1 1.2 1.3 2.6 -0.3 0.8 0.0 0.1 -0.4 0.4 0.5
Neuroticism (Nagel 2018) 0.3 0.8 4.9 -0.2 -0.4 -0.4 -1.1 -0.6 -0.4 -0.9 -0.3 -1.2 -2.2 1.4 -0.7 -0.7 0.8 0.3 -0.4 -0.3
Schizophrenia (2018) 0.4 0.7 2.0 -0.6 -0.9 0.0 -1.1 0.0 -1.3 -0.6 -0.2 -1.4 -1.1 -0.6 -1.2 -0.8 -0.6 -0.9 -0.9 -0.9
Schizophrenia vs Biploar Disorder 0.4 0.6 3.0 -1.1 0.9 1.7 -0.3 0.3 -0.5 -1.1 0.3 -0.9 -0.7 0.2 -0.5 1.0 0.5 0.2 0.2 0.3
Worry (Nagel 2018) 0.4 0.8 4.6 0.2 -0.2 -0.3 -2.1 -0.7 -0.1 -0.3 0.0 -1.1 -1.8 1.5 -0.4 -0.2 1.1 -0.0 -0.3 0.4
Alzheimer’s Disease (in mother) 1.7 2.0 5.2 -1.4 -1.9 -1.2 0.2 0.1 -1.2 -2.0 -1.9 -1.6 -1.6 2.3 -1.5 -0.9 0.3 1.1 -1.2 -1.2
Alzheimer’s Disease (in father) 0.8 0.9 5.9 1.4 0.6 1.6 -2.4 -0.5 0.6 1.1 0.2 0.8 -0.3 -1.0 0.5 0.1 0.5 -0.4 0.6 0.3
Alzheimer’s Disease (including proxy) 0.4 0.6 2.9 -0.4 -1.1 0.4 -1.7 0.1 -0.2 -1.0 -1.1 -0.7 -1.1 0.9 -0.5 -0.2 0.9 0.4 0.1 -0.3
Crohns Disease (2017) 0.9 1.9 4.5 -1.9 -2.0 0.7 2.1 -0.8 -1.6 -2.0 -1.0 -1.8 0.2 -0.4 -1.6 0.2 -1.1 -1.1 -1.6 -0.8
Irritable Bowel Disease (IBD) 0.9 2.2 8.6 -2.5 -2.1 0.1 2.1 -0.7 -1.3 -2.9 -1.1 -1.9 -0.0 0.8 -1.3 0.3 -1.1 0.1 -1.7 -0.9
Ulcerative Colitis (UC) 0.7 1.3 6.8 -2.1 -1.1 -0.3 1.2 -0.3 -0.5 -2.6 -0.4 -1.2 -0.3 1.5 -0.6 0.5 -0.3 1.1 -1.4 -0.3
Major Depression (MDD) 1.9 2.3 5.9 2.4 1.5 0.4 0.2 2.1 1.7 1.8 1.3 1.3 0.7 -1.5 1.6 1.5 0.9 -0.3 2.3 1.7
Reaction Time 0.4 0.7 5.1 -0.0 -0.6 0.4 -2.3 0.6 -0.3 -0.4 -0.6 -0.6 -1.7 -1.1 -0.2 0.2 -0.4 0.1 0.3 0.2
Verbal and Numeric Reasoning (VNR) 1.9 4.6 14.9 1.8 2.5 1.2 1.3 2.0 2.2 2.6 3.2 2.4 3.9 -1.9 1.9 1.2 1.8 -0.9 1.7 2.0
Breast Cancer 0.5 1.2 3.1 -1.6 -0.6 -0.9 1.6 -0.7 -1.2 -0.9 -1.4 -0.8 -0.8 -0.2 -1.0 -0.7 -1.8 -0.5 0.1 -1.7
Ovarian Cancer 0.4 0.6 3.5 0.2 -0.8 -1.9 -1.7 -0.3 -0.2 0.5 0.2 0.1 -0.4 1.0 0.1 -0.6 -0.6 -0.5 -0.4 0.1
Prostate Cancer 0.4 0.6 1.8 -0.8 0.5 -0.4 -0.9 -1.1 -0.7 0.2 0.8 -0.5 0.2 0.4 -0.8 -1.3 -0.0 -1.0 -1.1 -0.7
Age at First Birth 0.1 0.2 1.2 -0.8 -0.1 -0.1 -0.1 -0.3 0.2 -0.3 0.2 0.1 0.1 1.1 0.1 -0.3 0.7 0.8 -0.4 0.1
Bipolar Disorder (2011) 2.4 2.3 5.1 1.6 0.8 -0.3 0.1 1.6 1.9 1.2 1.7 1.3 1.4 -2.1 1.8 2.3 0.8 0.2 1.8 2.3
Body Mass Index (BMI) (2010) 0.3 0.5 1.6 -1.3 -0.1 -0.2 0.9 -0.8 -1.0 -0.6 -0.6 -0.4 -0.3 0.1 -0.9 -0.7 -0.3 -0.3 -0.8 -0.9
Coronary Artery Disease (CAD) 0.2 0.2 1.4 -0.4 0.6 0.1 0.0 0.2 0.1 0.3 0.5 0.2 0.7 1.2 0.0 0.2 0.2 1.0 -0.4 -0.3
Crohns Disease (2012) 2.2 3.5 8.5 -2.1 -2.9 -0.5 1.2 -1.5 -2.4 -2.1 -1.3 -2.8 -0.9 0.4 -2.5 -1.2 -1.3 -2.3 -2.2 -1.5
Mean Putamen Volume 0.6 0.6 2.1 0.7 1.0 0.6 0.8 -1.3 0.2 0.1 -1.1 0.2 0.7 -0.4 0.7 0.6 -1.3 -0.5 1.5 0.1
Fasting Glucose 0.6 0.7 2.4 1.4 0.6 1.2 -0.7 0.0 0.6 1.5 -0.1 0.3 -0.2 -0.4 1.1 -0.2 -0.9 -0.4 1.5 0.3
HbA1C 0.3 0.4 1.2 1.0 1.1 0.1 -1.1 -0.2 0.1 0.6 0.7 0.0 -0.2 0.4 0.1 -0.7 -0.5 -0.5 1.0 -0.4
HDL Cholesterol 1.5 2.6 7.1 2.5 1.3 -0.3 1.1 2.0 1.9 2.7 0.9 1.9 0.9 -1.3 1.5 1.0 1.7 0.9 1.9 1.5
LDL Cholesterol 1.4 2.3 6.8 -1.0 -1.6 -1.7 -0.4 -0.7 -1.4 -0.9 -1.8 -1.4 -2.1 2.6 -1.5 -1.9 -1.4 0.1 -1.0 -2.1
Lupus 0.9 1.4 4.1 1.5 1.0 1.0 2.0 0.5 0.8 1.2 1.1 1.5 1.5 -1.7 1.2 0.7 -0.6 0.5 1.4 0.1
Neuroticism (2016) 0.2 0.3 0.7 0.2 -0.2 -0.7 -0.8 0.5 -0.0 0.0 0.1 0.7 -0.8 0.8 0.5 0.5 -0.6 0.7 0.4 0.5
Primary Biliary Cirrhosis 1.7 2.4 5.9 1.1 1.5 -0.5 -0.6 1.7 2.3 1.1 0.6 1.9 1.0 -0.2 2.3 2.3 1.4 1.4 1.4 2.4
Rheumatoid Arthritis 0.3 0.5 2.1 1.3 0.3 0.7 -0.0 0.5 0.8 0.7 0.7 0.2 -0.4 -0.4 0.7 0.2 0.5 -0.9 1.5 0.2
Schizophrenia (2014) 0.1 0.2 0.9 -0.2 -0.4 -0.1 -0.3 0.4 -0.6 -0.2 -0.4 -0.9 -0.7 -0.5 -0.4 0.1 -0.6 -0.4 0.1 -0.1
Triglycerides 0.6 1.0 2.5 0.2 1.3 0.6 0.3 0.5 1.4 1.0 0.7 1.3 0.9 0.5 1.3 1.3 0.9 1.1 0.6 1.6
Type 2 Diabetes (T2D) (2012) 0.5 0.5 3.8 -0.3 0.5 -0.5 -0.9 -1.9 -0.4 1.2 -1.0 -0.1 -0.6 0.1 -0.3 0.5 -0.7 -0.2 0.2 -0.4
Ulcerative Colitis 0.2 0.3 1.1 -0.9 -0.4 -0.6 0.5 0.3 0.1 -1.0 0.4 -0.5 0.2 0.9 0.1 0.2 -0.1 0.1 -0.6 0.3
Blood Eosinophil Count 0.5 4.0 39.4 0.3 0.4 -1.2 -6.3 -2.5 -0.6 0.5 -2.3 -0.9 -0.8 3.2 -1.0 -1.2 0.4 -0.9 -0.4 -1.0
Blood Platelet Count 1.6 18.4 37.2 3.9 4.2 2.2 1.9 5.8 5.6 3.6 4.2 4.2 3.6 -2.1 4.4 4.9 6.1 3.6 4.0 5.5
Blood Red Count 0.2 1.9 21.0 0.7 0.9 1.6 0.6 0.5 0.4 1.4 1.2 0.5 4.6 -0.3 0.3 -0.1 1.0 -0.9 -0.1 0.7
Blood White Count 0.4 2.6 9.2 0.4 1.6 -0.1 1.6 2.8 1.8 -0.3 0.7 1.7 1.5 -0.1 1.4 2.1 2.1 3.0 1.1 1.4
Heel T-Score 0.9 7.3 27.5 -4.3 -2.9 -2.8 2.1 -2.3 -2.0 -2.4 -1.8 -1.5 -5.2 3.1 -2.0 -0.3 -0.8 3.3 -2.2 -2.5
BMI 0.3 1.6 10.1 0.4 1.3 1.4 0.5 0.9 0.6 1.4 1.2 0.9 3.2 -1.2 0.4 1.3 1.8 -0.2 -0.1 1.2
Height 5.7 110.1 171.6 -9.7 -11.5 -9.2 -3.2 -13.1 -13.1 -9.2 -12.7 -11.6 -12.1 8.1 -12.4 -10.3 -8.3 -6.1 -10.7 -11.6
Waist Hip Ratio (WHR) 0.3 1.4 4.1 0.4 0.8 0.1 -0.5 0.6 0.9 0.3 -1.4 1.3 -0.0 0.5 1.6 2.0 -2.0 1.4 2.0 0.4
Systolic Blood Pressure 8.5 42.6 73.4 7.4 8.2 3.7 0.8 3.1 8.2 7.6 7.8 7.8 8.6 -4.9 8.2 5.6 4.3 1.1 7.9 7.4
Smoking Status 0.8 1.9 4.8 -2.2 -0.8 -1.1 0.9 -1.0 -1.1 -1.6 -1.6 -0.7 -1.7 1.8 -0.8 -0.1 -1.2 2.1 -1.2 -1.3
Allergy or Eczema 1.2 3.1 10.0 1.5 1.3 1.5 1.0 0.9 1.8 1.2 2.6 2.1 3.2 -2.3 2.0 1.2 0.6 -0.8 1.6 2.1
Cardiovascular Disease 0.4 1.3 3.2 1.2 1.0 -0.2 1.0 0.2 1.4 1.8 1.6 1.4 0.9 -0.4 1.3 0.8 1.0 1.1 1.3 1.2
Hypothyroidism (self reported) 0.6 1.3 11.8 0.8 1.1 1.0 -3.4 -1.2 0.4 1.0 -0.6 0.6 -0.3 1.2 -0.1 -0.1 1.7 -0.3 0.1 0.3
Respiratory disease 0.4 0.8 4.9 0.8 -1.1 -1.1 2.2 1.7 0.3 -0.6 -0.2 -0.5 -0.4 -0.6 0.3 0.8 0.3 0.6 0.4 0.9
Type 2 Diabetes (T2D) (2018) 0.8 1.5 5.6 2.4 0.9 0.3 -0.1 -0.8 1.4 1.9 0.2 1.4 1.0 -0.6 1.5 0.9 0.8 0.9 2.2 0.9
Lung FEV1/FVC ratio 2.4 12.1 25.7 4.2 3.9 2.9 0.4 3.4 4.0 4.3 3.3 3.9 5.1 -2.6 3.5 3.1 3.1 1.1 3.9 3.4
Lung FVC 1.7 8.5 25.5 -3.2 -3.9 -1.1 1.0 -2.8 -3.7 -2.8 -2.1 -3.3 -5.1 0.4 -3.3 -2.6 -2.6 -1.9 -3.2 -3.0
Neuroticism 0.3 0.8 3.6 0.4 0.3 1.4 -1.1 0.1 0.1 -0.3 1.0 -0.8 -1.9 0.7 -0.5 -0.4 1.6 0.2 -0.7 0.2
Chronotype (morning person) 1.4 3.2 8.7 2.3 2.1 2.1 -2.4 0.9 1.7 2.9 0.8 1.8 2.0 -1.8 1.9 0.3 0.8 -0.3 1.8 1.7
Hair Pigment 0.0 0.3 1.0 0.1 0.1 0.2 1.0 0.7 0.3 -0.4 0.0 -0.2 0.6 -0.0 0.1 0.9 0.7 0.2 0.8 0.4
Tanning 0.1 1.6 7.0 -2.1 -0.6 -0.2 -1.1 -0.6 -1.4 -2.6 -0.8 -1.2 -1.5 0.9 -1.6 -0.9 -0.1 -0.3 -0.4 -1.5
Hand grip strength (left) 0.1 0.3 0.9 -1.0 -0.4 0.0 -0.3 -0.9 -0.5 0.2 -0.9 0.2 0.4 -0.2 -0.4 0.3 -0.6 0.2 -1.0 -0.1
Number of treatments/medications taken 0.4 0.7 2.2 -0.5 0.1 -0.7 -0.6 -1.5 -0.7 -0.6 0.3 -1.3 -0.7 1.1 -1.1 -0.9 1.0 -0.2 -0.5 -0.9
Average weekly spirits intake 2.6 3.2 7.2 -1.7 -0.7 -0.6 -0.8 -2.0 -2.7 -0.7 -0.7 -1.9 -2.4 1.5 -1.9 -2.1 -2.6 -1.5 -1.6 -2.6
Sensitivity / hurt feelings 0.3 0.5 2.3 -1.1 0.1 0.3 -0.7 -1.3 -0.5 -0.5 0.1 -0.6 -0.8 0.7 -0.4 -0.6 -0.1 -0.1 -1.5 -0.1
Frequency of depressed mood in last 2 weeks 0.5 0.6 2.0 -0.2 -1.4 -1.2 0.6 0.1 0.4 0.0 -0.4 0.1 -0.6 0.7 0.1 0.4 1.4 1.4 -0.8 0.9
Hearing difficulty/problems: Yes 0.5 0.7 4.0 -0.5 -0.7 0.8 2.0 1.9 0.2 -0.7 0.7 0.2 -0.7 0.4 0.2 1.0 0.4 0.6 0.1 0.8
Relative age of first facial hair 1.4 2.9 7.8 1.8 2.8 2.4 1.3 1.6 1.8 1.6 2.3 1.9 1.4 -0.3 1.9 1.1 1.4 0.3 1.6 1.7
Other serious medical condition/disability diagnosed by doctor 0.5 0.7 2.6 -1.5 -0.1 0.4 -0.2 -0.1 -0.7 -0.5 -0.4 -0.3 -1.6 1.3 -0.7 0.1 -0.3 1.4 -0.8 -0.9
Ever used hormone-replacement therapy (HRT) 0.6 0.7 2.7 0.5 1.2 -1.4 0.3 1.2 0.6 0.5 1.6 0.4 0.8 0.1 0.2 0.8 1.4 0.2 0.1 0.9
Ever had hysterectomy (womb removed) 0.4 0.5 2.3 0.3 0.3 -0.4 0.9 0.5 0.8 0.1 0.8 0.3 0.3 0.9 0.4 0.6 1.2 1.5 0.5 0.4
Systolic blood pressure, automated reading 8.1 23.6 45.8 5.3 6.6 2.9 0.2 1.8 6.0 5.2 5.7 5.6 6.8 -3.5 6.0 4.6 3.4 0.3 5.5 5.8
Eye problems/disorders: Diabetes related eye disease 0.7 0.8 3.4 0.6 -0.0 -0.1 0.3 0.0 1.3 0.8 0.3 0.9 -1.1 -0.5 1.1 1.5 0.7 1.8 0.5 0.9
Angina 0.3 0.3 2.0 0.2 0.7 1.4 -0.3 -0.1 -0.1 0.0 0.6 -0.3 -1.0 -0.5 -0.1 -0.4 0.7 0.7 -0.5 -0.1
Medication for hormone replacement therapy 0.8 0.9 3.0 0.8 1.7 -0.5 1.0 1.2 0.8 0.2 1.2 0.5 -0.0 -0.7 0.5 0.1 0.8 -1.6 -0.1 1.4
Vitamin and mineral supplements 0.7 0.9 2.9 0.6 1.1 1.7 0.2 0.3 0.6 1.1 1.0 1.2 1.2 -0.8 1.0 0.7 0.0 -0.5 1.6 0.5
Supplements: Zinc 0.4 0.4 2.4 -0.3 0.1 -0.4 0.1 0.6 -0.0 -0.5 -0.0 0.1 -1.4 0.8 0.0 -0.1 -0.4 1.6 -0.3 -0.6
Medication: Co-codamol 0.3 0.3 1.1 0.5 -0.4 -0.8 -0.6 0.8 0.3 -0.4 -0.7 -0.5 -0.1 -0.1 -0.0 0.5 0.8 1.0 0.2 0.1
Medication: Metformin 0.8 1.1 3.0 1.6 0.4 -0.1 -1.4 -1.5 1.0 1.7 -0.0 0.6 1.2 -0.5 1.0 0.8 0.5 0.1 1.7 0.8
Diabetes (father) 1.0 1.3 5.4 -0.7 0.6 -0.0 -2.3 -2.2 -0.8 -0.5 -1.5 -0.5 -0.7 0.6 -0.5 -1.5 -0.9 -0.1 -0.9 -1.3
Diabetes (mother) 0.8 1.0 2.6 1.6 1.1 0.9 -1.1 -1.0 0.9 1.0 0.2 1.1 1.2 -0.8 1.4 0.1 -0.5 -0.6 1.6 0.6
Severe depression (siblings) 0.4 0.4 1.5 0.7 0.2 -0.4 0.8 1.1 0.4 1.2 0.3 0.8 -0.3 -0.3 0.6 0.2 -0.5 -0.3 0.8 0.3
Pack years adult smoking proportion 0.7 1.1 3.5 -0.2 -1.4 -1.1 -0.1 -0.3 -1.1 -0.8 -1.1 -1.8 -0.8 -0.1 -1.1 -1.9 -0.5 -0.2 -1.1 -1.4
Impedance of leg (right) 1.0 5.1 14.8 1.7 2.5 0.5 1.5 0.8 2.7 1.7 0.4 3.3 2.9 -1.4 3.4 2.9 -1.3 1.4 3.9 2.0
Leg fat-free mass (left) 4.8 25.2 46.4 -5.3 -5.5 -2.7 -2.0 -4.9 -6.7 -4.6 -5.2 -6.0 -5.0 3.4 -6.7 -5.7 -2.1 -2.7 -6.8 -5.8
Trunk fat percentage 0.9 3.4 16.9 1.4 3.2 1.4 1.3 -0.3 1.2 1.7 1.8 1.6 4.1 -1.6 1.3 1.6 1.4 -0.9 1.9 1.3
Hand grip strength (right) 0.6 1.7 4.9 -1.2 -1.6 -1.4 0.8 -2.2 -1.7 0.2 -1.5 -0.9 -1.4 0.7 -1.4 -0.8 -1.4 -1.0 -1.2 -1.2
Townsend deprivation index at recruitment 0.4 0.6 2.8 -0.2 0.6 1.7 1.1 1.0 -0.1 -1.1 1.5 -0.4 -0.2 -0.5 -0.3 -0.1 0.4 0.1 -0.6 -0.2
Current tobacco smoking 0.4 0.6 3.0 0.1 -0.2 -0.0 -0.5 -1.1 -0.1 -0.1 -1.7 -0.1 -0.1 -0.8 0.5 -0.3 -1.7 0.9 0.5 -0.9
Average weekly fortified wine intake 2.4 2.8 6.1 -1.8 -1.7 -0.6 -1.5 0.0 -1.7 -2.5 -1.4 -2.2 -0.5 1.7 -2.1 -2.2 -0.4 -0.3 -2.4 -2.2
Maternal smoking around birth 0.4 0.6 3.6 -1.2 0.3 0.2 0.9 0.3 -1.0 -0.3 1.9 0.0 -0.6 -0.5 -0.7 -0.1 -0.6 -0.0 -1.3 -0.5
Fed-up feelings 0.6 1.1 5.1 1.3 0.6 1.9 -1.3 0.6 1.1 0.3 -0.4 -0.3 -0.7 -0.3 0.5 0.5 2.3 0.9 0.5 1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 2.9 -0.8 -1.7 -0.3 -0.4 0.4 -0.3 -1.2 -0.6 -0.9 -1.1 1.2 -0.9 -0.2 1.2 1.3 -1.4 0.1
Relative age voice broke 2.1 3.2 10.4 2.0 1.9 2.6 1.7 1.7 1.7 1.1 3.2 1.6 1.2 -1.1 1.6 1.3 1.6 -0.1 1.9 1.8
Taking other prescription medications 0.1 0.2 0.5 0.3 -0.6 -0.2 0.1 -0.5 -0.2 -0.6 -0.7 -0.7 -0.2 -0.0 -0.4 -0.7 0.4 0.3 -0.3 -0.6
Age when periods started (menarche) 0.4 1.1 3.8 -0.6 -0.1 -0.5 -0.5 0.1 -1.0 -0.7 -0.7 -0.8 -2.0 1.6 -1.1 -1.8 -0.4 -0.3 -1.2 -1.3
Bilateral oophorectomy (both ovaries removed) 0.8 1.0 3.0 1.0 1.7 0.3 0.6 -0.1 1.0 1.5 1.1 1.0 1.4 -0.4 1.2 0.8 -0.2 0.0 1.3 0.6
Heel bone mineral density (BMD) T-score, automated (left) 2.3 5.2 13.7 -3.7 -2.0 -0.9 -0.3 -2.2 -1.8 -3.4 -2.9 -2.3 -3.5 1.9 -2.0 -0.5 -0.6 2.0 -2.6 -2.2
Tinnitus: Yes, but not now, but have in the past 2.2 2.3 7.8 0.7 1.8 0.9 2.5 2.2 1.4 0.5 2.8 1.5 -0.6 -1.7 1.5 1.3 0.6 1.3 1.0 1.1
Qualifications: CSEs or equivalent 1.8 2.3 7.7 -1.1 -2.0 -0.8 -1.4 -0.9 -1.6 -1.0 -2.5 -1.0 -2.8 0.3 -0.9 -1.2 -2.7 -0.8 -0.7 -1.4
Serious illness, injury or assault to yourself 2.5 3.1 6.9 -2.0 -2.0 -1.6 -1.0 -1.1 -2.0 -2.2 -1.2 -2.4 -1.3 1.7 -2.6 -1.6 0.3 -0.8 -2.4 -1.7
High blood pressure 0.2 0.6 2.4 0.9 1.0 0.2 -0.1 -1.2 0.5 1.6 1.4 0.5 0.6 0.3 0.4 0.4 1.0 -0.2 0.8 0.5
Hayfever, allergic rhinitis or eczema 0.5 1.0 5.2 0.5 0.0 -0.3 1.2 -0.2 1.1 0.9 0.8 1.4 2.3 -1.0 1.1 0.8 0.3 -0.1 1.0 1.3
Multivitamins +/- minerals 0.4 0.5 2.4 0.2 -1.3 -1.5 -0.2 0.3 0.2 0.1 -0.8 -0.4 -0.8 -0.0 -0.0 -0.1 -0.1 0.9 -1.0 0.4
Stomach or abdominal pain in last month 2.1 2.6 7.0 -2.2 -1.6 -1.4 0.9 -1.0 -2.0 -2.7 -1.1 -1.9 -2.5 1.2 -1.7 -1.0 -0.8 0.1 -1.9 -1.2
Supplements: Glucosamine 0.3 0.4 3.1 0.3 0.1 -1.6 0.3 -0.2 -0.2 0.3 0.2 0.1 0.0 -0.4 -0.1 -0.5 -0.8 -1.8 0.2 -0.3
Diverticular disease/diverticulitis (self-reported) 4.2 4.9 9.7 -2.6 -2.1 -2.0 -0.5 -2.2 -2.8 -1.7 -3.0 -2.1 -2.4 3.1 -2.4 -1.4 -2.5 -0.5 -1.8 -2.5
Medication: Atenolol 0.3 0.3 1.5 1.1 0.2 0.4 -0.4 -0.1 0.3 1.2 0.3 0.4 0.3 -0.7 0.3 -0.1 0.2 -0.3 1.1 -0.1
Medication: Levothyroxine sodium 0.9 1.5 2.9 -1.2 0.1 -0.7 -1.6 -1.5 -1.4 -1.2 -1.6 -0.7 -1.3 1.7 -1.3 -1.3 -0.6 -0.2 -1.2 -1.4
Sitting height 6.6 46.8 82.8 -7.4 -7.2 -5.5 -5.6 -9.1 -8.1 -5.5 -7.6 -7.0 -9.1 5.6 -7.9 -5.7 -4.1 -2.5 -7.6 -7.1
Chronic bronchitis/emphysema (father) 0.4 0.4 1.7 -1.3 0.9 -0.3 -0.3 -0.5 -0.1 -1.2 0.9 -0.1 0.5 -0.0 -0.1 0.6 0.1 0.3 -0.9 0.2
High blood pressure (mother) 0.5 0.8 2.3 0.8 0.9 0.2 -1.5 -0.5 0.6 1.5 0.3 1.1 0.3 -0.4 1.0 0.5 -1.0 -0.6 1.5 0.3
Body mass index (BMI) 0.3 1.5 7.2 0.8 1.7 1.5 0.6 0.6 0.4 1.3 1.6 0.8 2.7 -1.3 0.4 0.6 1.6 -0.8 0.0 1.0
Impedance of leg (left) 1.3 6.4 19.2 2.6 2.8 0.5 1.6 1.0 3.0 2.7 1.2 3.5 2.9 -1.9 3.6 2.9 -0.8 1.1 4.4 2.3
Leg predicted mass (left) 4.7 24.9 45.8 -5.2 -5.4 -2.7 -1.9 -4.9 -6.7 -4.5 -5.2 -5.9 -5.0 3.3 -6.7 -5.7 -2.1 -2.8 -6.8 -5.7
Trunk fat mass 0.2 0.7 3.2 -0.4 0.7 -0.0 0.4 -1.8 -1.0 0.1 -0.3 -0.4 1.8 -0.3 -0.9 -0.4 0.3 -1.4 -0.5 -0.7
Waist circumference 0.1 0.4 3.4 -0.2 0.6 -0.0 0.1 -0.4 -0.6 0.5 -0.1 -0.1 1.9 -0.0 -0.5 -0.1 0.6 -0.6 -0.8 -0.1
Number of incorrect matches in round 0.1 0.2 1.1 -0.1 0.1 0.9 -0.6 0.2 0.4 -0.2 -0.2 -0.4 -0.1 0.4 0.3 0.6 0.7 1.0 0.0 0.3
Past tobacco smoking 1.4 2.5 5.9 2.2 1.5 1.4 -1.0 0.4 1.9 1.5 1.1 1.1 2.0 -2.4 1.8 1.2 1.3 -0.6 2.3 1.6
Alcohol usually taken with meals 3.3 5.3 12.1 2.7 1.8 1.1 1.9 2.6 2.5 3.5 2.5 2.6 3.2 -1.9 2.1 2.0 2.2 0.5 1.9 2.6
Nervous feelings 0.5 0.9 2.8 -0.7 -0.4 -1.1 -1.5 -0.8 -0.4 -0.6 -0.5 -1.2 -1.3 1.5 -0.6 -0.5 0.4 1.0 -1.7 -0.1
Frequency of tenseness / restlessness in last 2 weeks 1.7 2.7 9.0 -1.9 -1.5 -1.8 -0.5 0.0 -1.2 -1.5 -1.7 -1.3 -2.0 3.0 -1.7 -0.6 0.7 1.9 -2.6 -0.8
Hearing difficulty/problems with background noise 0.3 0.5 2.9 0.1 -0.2 0.4 1.1 1.7 0.3 -0.4 0.4 0.3 -0.3 -0.2 0.1 1.1 1.0 0.4 0.7 0.7
Hair/balding pattern: Pattern 2 1.3 1.7 4.5 -1.4 -1.9 1.3 2.1 0.6 -1.3 -1.9 -0.2 -2.1 -0.8 -0.0 -1.5 -0.7 -0.3 -0.4 -1.5 -0.8
Had menopause 0.3 0.4 2.8 0.1 1.1 0.9 -0.5 -0.3 0.2 0.1 1.2 -0.2 1.7 -0.0 -0.1 0.4 0.4 -0.6 0.1 -0.1
Had other major operations 1.6 2.0 5.9 1.2 1.4 -0.7 -0.1 1.1 1.8 1.1 1.8 1.0 1.9 -0.6 1.2 1.9 2.4 0.8 1.4 1.7
Forced vital capacity (FVC) 5.8 22.3 41.0 -5.0 -6.2 -4.2 0.2 -4.9 -5.7 -5.0 -5.8 -5.1 -6.4 2.3 -5.2 -4.4 -3.8 -2.4 -4.1 -5.3
Heel bone mineral density (BMD) T-score, automated (right) 1.2 2.7 8.6 -2.5 -1.3 -0.9 -0.3 -1.8 -1.1 -2.0 -2.1 -1.1 -2.9 1.3 -1.2 -0.3 -0.6 2.2 -1.7 -1.8
Ever unenthusiastic/disinterested for a whole week 2.0 2.4 6.0 -2.4 -2.0 -0.9 0.5 -1.2 -1.4 -2.5 -2.1 -1.1 -1.1 2.1 -1.6 -1.0 -0.1 0.9 -2.0 -1.3
Qualifications: None of the above 0.5 1.0 4.1 -0.5 1.2 0.9 -0.1 0.8 0.1 -1.5 1.6 -1.2 -1.5 0.1 -0.6 0.5 2.0 0.8 -0.6 0.3
Financial difficulties in last 2 years 2.1 2.8 6.9 -1.7 -1.6 -2.6 -1.1 -1.8 -1.9 -1.8 -2.2 -1.8 -1.7 1.5 -1.5 -1.3 -1.2 0.3 -1.9 -1.2
Mouth/teeth dental problems 1.0 1.5 3.5 1.4 0.7 -0.3 -0.8 0.3 1.7 1.9 0.4 1.7 1.3 -0.6 1.7 1.3 0.7 0.2 1.9 1.6
Heart attack 0.3 0.4 1.7 -0.2 0.1 0.5 1.2 -0.0 -0.6 0.1 0.5 -0.6 -1.3 0.1 -0.7 -0.4 0.4 0.4 -0.6 -0.8
Allergy 0.6 1.5 3.7 -1.0 -0.5 -0.1 -1.9 -0.6 -1.3 -1.0 -1.3 -1.5 -1.9 1.8 -1.3 -1.0 -0.3 0.3 -1.3 -1.4
Pain all over the body in last month 0.3 0.3 1.1 0.7 0.2 0.2 0.2 1.1 0.5 -0.1 0.7 0.5 0.5 -0.5 0.2 -0.2 0.9 0.6 0.1 0.1
Diabetes (self-reported) 1.0 1.5 5.5 2.3 0.9 0.2 -1.2 -1.9 0.9 2.2 0.4 1.0 0.8 -1.5 1.2 0.0 -0.2 -0.8 1.5 0.5
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 2.0 -0.4 0.4 -0.5 0.9 -0.3 -0.2 0.0 0.4 0.6 0.4 -0.1 0.2 -0.4 -1.4 -0.0 0.6 -0.8
Medication: Ramipril 0.5 0.7 2.9 0.9 0.9 -1.0 1.1 -0.1 0.6 1.0 1.7 0.7 0.2 0.5 0.3 0.3 1.1 0.3 0.8 0.4
Medication: Simvastatin 0.2 0.3 1.9 0.0 -0.2 -0.5 -0.5 -1.4 -0.5 -0.2 -0.3 -0.8 -0.7 0.3 -0.5 -0.2 0.0 -0.5 0.1 -0.5
Fluid intelligence score 0.9 1.9 8.9 1.3 1.1 0.1 0.4 1.6 1.6 1.6 1.6 1.9 3.0 -0.9 1.6 0.5 0.5 0.0 1.2 1.1
Illnesses of siblings 0.5 0.7 2.9 -0.3 0.7 1.0 0.7 0.7 0.6 0.2 0.2 1.2 0.4 -1.7 1.0 1.0 -0.3 1.3 0.0 0.7
Neuroticism score 0.3 0.6 2.8 0.1 0.5 0.9 -0.5 0.4 0.6 -0.1 1.0 -0.0 -1.4 0.5 0.3 0.5 1.7 1.1 -0.3 1.1
Weight 1.6 8.0 16.4 -2.8 -2.8 -1.6 -1.0 -3.4 -4.1 -2.0 -3.2 -3.2 -1.6 1.5 -4.0 -3.2 -1.0 -2.3 -4.0 -3.2
Impedance of arm (right) 0.9 4.0 13.4 2.2 2.3 0.6 0.7 -0.1 2.7 1.6 0.4 2.3 2.9 -1.2 2.8 2.4 0.3 1.1 3.7 1.9
Arm fat percentage (right) 1.3 5.2 21.0 2.1 3.2 1.8 1.0 0.5 2.0 2.3 2.3 2.3 4.6 -2.4 2.2 2.1 1.7 -0.4 2.3 2.0
Trunk fat-free mass 6.6 37.7 65.4 -5.9 -7.5 -4.3 -2.7 -5.5 -7.9 -5.2 -7.0 -6.9 -7.0 4.1 -7.9 -6.8 -3.2 -2.9 -8.1 -6.9
Hip circumference 0.2 1.0 3.3 -0.5 -0.3 -0.0 1.3 -0.3 -1.0 0.1 -0.0 -0.6 1.8 -0.4 -1.3 -0.8 1.7 -0.8 -1.8 -0.4
Time employed in main current job 1.7 2.0 5.8 -1.1 -1.2 0.0 -0.6 -2.2 -1.7 -1.1 -1.4 -1.2 -1.7 0.7 -1.1 -1.5 -2.4 -1.5 -0.1 -1.8
Alcohol intake versus 10 years previously 0.2 0.4 1.5 -0.1 -0.7 0.8 1.2 0.7 -0.3 -0.9 0.1 -0.4 -0.1 -0.7 -0.4 -0.3 0.3 0.7 -0.4 -0.6
Father’s age at death 0.3 0.4 1.5 0.9 -0.1 0.3 0.6 1.2 -0.1 0.4 0.1 -0.3 0.6 -0.3 -0.4 -1.1 0.6 -0.5 -1.2 -0.1
Worrier / anxious feelings 0.7 1.3 3.7 1.6 1.8 1.8 -1.9 0.3 1.1 1.0 1.2 0.7 -0.5 -0.2 1.0 0.1 1.1 0.0 0.8 1.0
Frequency of tiredness / lethargy in last 2 weeks 1.8 2.9 7.9 -1.2 -2.3 -1.8 -0.0 -0.5 -1.4 -2.1 -1.4 -2.2 -2.7 2.8 -1.7 -1.1 0.5 0.8 -2.1 -0.8
Falls in the last year 3.2 4.3 9.4 -2.6 -2.3 -1.5 -1.3 -1.0 -2.4 -3.0 -1.9 -3.1 -2.0 1.3 -2.8 -1.8 0.2 0.2 -2.9 -1.9
Hair/balding pattern: Pattern 3 0.4 0.6 2.8 0.5 -0.0 -1.7 -1.1 -0.8 -0.4 0.4 0.4 -0.5 0.1 0.4 -0.7 -1.4 0.2 -1.2 -0.0 -0.9
Number of live births 0.3 0.5 1.9 -1.3 -0.6 0.2 0.4 0.8 -0.6 -0.6 0.0 -0.7 -1.4 0.2 -1.1 0.0 0.8 -0.5 -0.1 -0.6
Forced expiratory volume in 1-second (FEV1) 3.0 10.1 22.8 -3.4 -4.8 -2.8 0.6 -3.2 -3.8 -3.1 -4.0 -3.7 -4.4 1.5 -3.7 -2.5 -1.7 -1.5 -2.8 -3.3
Pulse rate 0.1 0.2 1.0 0.5 0.4 0.3 -1.0 0.1 0.2 0.2 -0.5 0.2 -0.1 0.3 0.2 -0.5 0.2 -0.3 0.2 0.2
Happiness 2.6 3.2 6.7 -1.8 -2.4 -1.4 -0.5 -1.0 -1.5 -2.4 -2.6 -1.3 -1.9 2.6 -1.6 -1.5 -0.8 1.4 -1.8 -1.9
Noisy workplace 0.4 0.5 3.5 -0.9 0.6 -0.4 -0.0 -0.2 0.3 -0.9 0.0 0.3 -1.0 0.5 0.4 0.9 0.7 1.9 -0.3 0.5
Qualifications: A levels/AS levels or equivalent 0.6 1.4 8.8 1.2 -0.0 -0.6 3.0 2.2 0.5 1.6 0.1 1.5 1.0 -0.4 0.8 -0.2 -0.6 -0.5 1.1 0.2
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 1.8 0.1 0.3 -1.0 0.6 1.4 0.2 0.1 0.4 0.2 0.2 0.9 -0.2 -1.2 1.0 0.1 -1.0 0.1
Mouth/teeth dental problems: Dentures 0.7 1.2 10.1 0.2 1.6 3.2 0.2 1.5 0.7 -0.4 1.1 0.2 0.7 -1.4 0.4 0.6 0.7 0.4 0.1 0.3
Asthma 0.6 1.2 4.6 1.3 -0.0 -1.0 2.2 1.0 1.1 0.5 0.5 0.6 1.2 -1.3 1.3 1.1 0.4 0.3 1.2 1.6
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 2.4 -1.4 -0.1 -0.8 0.5 -0.5 -0.6 -1.0 -0.4 -0.4 -0.4 1.6 -0.8 -0.4 0.5 0.8 -0.9 -0.6
Medication: Cholesterol lowering 0.3 0.5 2.4 0.8 0.6 -0.6 1.2 -0.3 0.3 0.6 1.6 0.2 -0.9 0.4 0.4 -0.2 -0.0 -0.4 0.8 -0.2
Depression (self-reported) 0.5 0.6 1.5 0.8 -0.9 -0.1 -0.8 1.0 0.6 -1.0 -1.2 0.1 -1.2 -0.5 0.6 0.2 0.3 0.6 0.6 0.8
Medication: Lansoprazole 1.7 1.9 5.1 0.9 2.0 2.3 2.0 2.1 1.2 0.7 1.6 1.5 0.6 -1.8 1.3 0.3 -0.0 0.9 0.9 0.3
Prospective memory result 0.2 0.3 1.1 -0.5 0.3 -0.4 0.2 -0.3 -0.7 -0.8 -1.0 -0.4 -0.2 0.0 -0.6 -0.4 -0.5 -0.4 -0.3 -0.5
Lung cancer (father) 0.8 0.9 1.8 -0.9 -1.1 -0.1 -1.2 -0.5 -0.9 -1.3 -1.4 -1.4 -0.4 1.2 -1.1 -1.0 -0.1 -0.2 -1.1 -0.6
Illnesses of mother 1.0 1.2 4.1 0.0 0.4 1.4 1.6 1.9 0.8 -0.2 0.5 0.6 0.3 -0.6 0.3 1.1 2.0 1.9 -0.3 1.1
Forced expiratory volume in 1-second (FEV1), Best measure 2.1 6.7 14.3 -2.3 -3.6 -1.4 0.0 -3.3 -3.2 -2.0 -3.8 -2.9 -3.8 0.5 -2.9 -1.9 -2.2 -1.8 -2.2 -2.5
Pulse wave Arterial Stiffness index 0.5 0.6 3.8 1.4 -0.3 0.3 2.0 0.9 0.2 0.9 0.2 0.1 -0.6 0.4 0.1 0.1 0.7 -0.7 0.2 0.4
Impedance of arm (left) 0.9 4.0 15.2 2.3 2.5 0.6 1.3 0.2 2.6 1.7 0.7 2.1 2.5 -0.9 2.7 2.4 0.3 0.8 3.9 1.9
Arm fat mass (right) 0.1 0.6 2.6 -0.3 0.4 0.4 0.2 -1.2 -1.0 0.2 -0.2 -0.4 1.6 -0.6 -0.9 -0.5 0.4 -1.3 -0.7 -0.6
Trunk predicted mass 6.6 37.9 65.2 -6.0 -7.5 -4.2 -2.7 -5.6 -7.9 -5.2 -7.0 -7.0 -7.0 4.1 -7.9 -6.9 -3.3 -3.1 -8.1 -6.9
Standing height 6.9 68.5 105.5 -8.0 -9.9 -6.8 -3.4 -9.3 -10.2 -7.3 -10.3 -9.0 -9.5 6.1 -9.9 -8.4 -5.8 -3.9 -9.1 -9.4
Length of working week for main job 0.4 0.5 1.6 0.8 -0.3 0.3 -1.1 -0.3 -0.5 -0.4 -0.1 -0.9 -0.2 0.6 -0.9 -0.8 0.8 -1.3 0.1 -0.3
Exposure to tobacco smoke at home 0.2 0.2 1.0 0.0 -0.7 -1.0 0.4 -0.8 0.0 0.3 0.3 -0.3 -0.2 -0.0 0.2 -0.3 -0.5 -0.0 -0.4 -0.1
Breastfed as a baby 1.3 1.6 4.0 -1.5 -0.2 0.6 0.5 -1.9 -1.6 -1.4 -0.4 -1.5 -2.0 0.9 -1.4 -1.2 -1.0 -1.1 -1.2 -1.5
Tense / ‘highly strung’ 1.4 2.3 7.3 -1.6 -0.8 -1.9 -1.4 -0.5 -1.4 -1.5 -1.1 -1.9 -2.1 2.7 -1.8 -0.9 0.6 0.4 -1.9 -0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.4 2.1 0.1 -0.6 -0.2 0.5 1.5 0.5 -0.1 0.3 0.5 0.2 0.2 0.3 0.7 1.0 0.7 -0.2 0.9
Hair/balding pattern: Pattern 4 0.4 1.0 3.3 0.2 0.6 -0.9 -0.5 0.3 1.3 0.7 -0.1 1.1 0.4 0.0 1.1 1.8 1.4 1.4 -0.1 1.8
Birth weight of first child 1.3 2.4 7.9 -0.9 -1.1 -0.6 -0.2 -1.4 -2.6 -1.1 -0.8 -1.5 -2.2 -0.7 -2.2 -1.3 -1.9 -2.8 -0.9 -1.5
Peak expiratory flow (PEF) 0.3 0.8 2.8 -1.3 -1.7 -1.2 1.3 0.0 -0.7 -0.9 -0.4 -1.0 -0.5 -0.2 -1.1 0.5 0.8 -0.6 -0.0 -0.3
Pulse wave reflection index 0.7 0.8 2.3 -0.0 -1.3 0.5 1.3 -0.2 -0.9 -0.6 -0.3 -1.0 -1.5 0.3 -0.9 -1.1 -0.6 -0.5 -1.5 -1.0
Ever highly irritable/argumentative for 2 days 0.9 1.1 3.3 -1.2 -0.8 0.4 -1.1 1.1 -0.5 -1.2 -0.6 -1.1 -1.3 0.3 -1.1 -0.8 1.8 1.0 -1.4 -0.4
Loud music exposure frequency 0.5 0.5 1.5 -0.9 -0.5 -1.2 0.2 0.2 -0.4 -0.5 0.8 -0.5 -0.5 0.8 -0.5 -0.3 0.4 1.2 -1.2 -0.6
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 1.8 0.3 -1.2 -0.9 -0.1 -0.5 -0.1 1.2 -1.4 0.4 -0.6 -0.2 0.2 -0.0 -0.8 -0.7 0.8 -0.1
Mouth/teeth dental problems: Bleeding gums 2.0 2.6 6.2 -2.5 -1.3 -0.5 0.7 -1.4 -2.1 -2.4 -1.6 -1.7 -0.4 0.8 -2.0 -1.8 -1.3 -0.2 -1.9 -2.3
Blood clot in the leg (DVT) 0.3 0.4 2.2 0.1 0.2 0.3 -0.9 -0.3 0.3 0.6 0.2 0.7 1.3 -1.5 0.5 -0.0 -0.7 -0.7 -0.4 0.2
Medication: Paracetamol 1.0 1.7 4.8 -2.2 -1.2 -0.9 -0.7 -1.6 -0.7 -1.3 -0.8 -1.1 -1.9 2.1 -1.1 0.3 0.7 1.7 -1.5 -0.6
Headache pain in last month 2.2 3.8 11.8 -2.4 -2.2 -1.6 0.3 -1.2 -2.1 -2.0 -1.1 -1.6 -3.4 2.7 -1.9 -1.8 -1.8 0.4 -1.7 -2.4
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 2.2 -0.4 -0.9 0.6 0.3 0.3 -0.4 -0.3 -1.5 -0.2 0.7 -1.0 -0.4 0.0 -0.6 -0.3 -0.5 0.0
Glaucoma (self-reported) 0.3 0.3 1.2 0.5 -0.0 1.1 -1.0 -0.2 0.4 1.1 0.2 0.5 0.0 -0.7 0.5 0.3 0.1 0.2 0.3 -0.0
Gout (self-reported) 1.0 1.4 3.8 0.9 2.0 1.4 0.8 0.2 1.0 1.5 1.1 1.9 1.1 -1.0 1.5 1.1 -0.3 -0.3 1.3 1.3
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 3.4 0.7 1.6 0.6 -1.2 -0.2 0.6 0.8 0.1 0.7 -0.0 1.7 0.1 -0.0 1.9 0.4 0.2 0.3
Medication: Amlodipine 1.2 1.7 4.5 1.1 1.7 0.1 1.1 0.2 1.5 2.1 2.1 1.4 1.9 -0.3 1.5 1.3 0.8 0.6 0.9 1.4
Medication: Ventolin 100micrograms inhaler 0.2 0.2 1.1 0.3 -0.6 -0.4 0.4 -0.2 0.2 -0.1 -0.4 -0.2 0.6 -0.6 0.6 -0.3 -1.1 0.3 0.6 -0.1
Birth weight 2.3 5.0 15.6 -1.6 -1.0 -1.3 -2.2 -2.1 -2.7 -1.5 -1.4 -2.4 -3.9 0.2 -2.4 -3.0 -2.1 -2.3 -2.3 -2.7
Chronic bronchitis/emphysema (mother) 0.3 0.4 1.1 0.8 1.0 -1.0 0.3 0.1 0.2 0.9 0.5 0.3 -0.5 0.0 0.3 -0.8 -0.3 -0.8 0.6 -0.4
High blood pressure (siblings) 0.5 0.7 2.2 -0.9 -0.2 -0.4 -0.1 -1.5 -1.1 -0.8 0.4 -1.1 -0.9 1.1 -1.0 -0.4 -0.7 -1.3 -0.2 -0.7
Forced vital capacity (FVC), Best measure 5.1 18.8 36.4 -4.1 -5.6 -2.9 -0.5 -5.0 -5.3 -4.1 -5.8 -4.9 -6.0 1.4 -4.8 -3.9 -3.8 -2.9 -3.9 -4.5
Body fat percentage 1.1 4.5 20.8 1.6 3.4 1.7 1.6 0.3 1.6 2.0 2.2 2.1 4.6 -2.0 1.8 2.0 1.4 -0.6 2.1 1.7
Leg fat percentage (right) 1.5 5.5 25.0 1.4 3.4 1.8 1.5 1.0 2.1 1.9 2.3 2.9 5.0 -2.2 2.5 2.5 1.0 0.1 2.0 2.3
Arm fat-free mass (right) 5.6 28.8 51.7 -5.3 -6.3 -3.3 -1.9 -4.9 -7.2 -4.6 -5.4 -6.2 -5.9 3.5 -7.2 -6.1 -2.8 -3.2 -7.1 -6.2
Exposure to tobacco smoke outside home 0.4 0.5 2.0 0.3 -0.3 -1.3 1.1 0.5 -0.4 0.1 1.4 -0.5 -1.4 0.1 -0.3 -0.1 -0.5 -0.6 -0.7 0.4
Comparative body size at age 10 0.2 0.4 1.9 0.2 0.3 0.3 -0.7 -0.1 0.5 0.9 -0.1 0.6 -0.2 0.4 0.3 0.3 1.3 0.5 -1.4 1.0
Number of full brothers 2.7 3.4 9.4 -2.2 -2.4 -0.7 -0.4 -0.4 -1.4 -3.1 -2.3 -1.7 -1.2 2.5 -2.0 -1.6 0.7 1.9 -2.3 -1.6
Worry too long after embarrassment 0.3 0.4 1.8 -0.2 0.1 1.3 0.3 0.7 -0.1 -0.7 0.5 -0.7 -1.1 0.9 -0.5 -0.1 1.0 0.2 -0.4 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.7 2.9 0.5 -0.0 -0.5 1.5 1.7 0.5 -0.1 0.7 0.1 -0.6 1.0 -0.1 0.6 1.7 0.7 -0.3 0.9
Wheeze or whistling in the chest in last year 0.5 0.9 4.5 0.2 0.6 -0.3 1.6 1.0 0.8 -0.7 0.8 0.6 -0.0 -0.5 0.9 0.9 0.9 2.1 0.2 1.1
Number of children fathered 0.3 0.4 1.9 -0.9 -0.1 -0.0 0.1 -0.2 -0.3 -0.5 0.8 -0.3 0.5 -0.9 -0.2 -0.5 -0.7 -1.4 -0.8 -0.5
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.3 1.1 0.9 -0.1 -0.5 0.3 -0.5 -0.1 1.0 0.2 -0.6 -0.7 0.3 -0.2 0.0 0.3 -0.9 0.6 0.3
Age at first live birth 0.3 0.5 2.1 0.9 0.3 -1.4 0.2 -0.1 0.3 1.1 -0.4 0.9 1.0 0.9 0.6 -0.6 -0.6 -0.3 0.4 0.2
Pulse wave peak to peak time 1.1 1.3 5.6 -1.9 -0.4 -0.8 -2.4 -1.6 -1.0 -1.4 -1.0 -0.7 -0.1 -0.0 -0.8 -0.7 -1.1 0.4 -0.9 -1.1
Health satisfaction 1.9 2.5 6.0 -1.2 -1.7 -1.6 -0.2 -1.5 -1.6 -1.2 -1.8 -1.9 -2.4 1.7 -1.7 -1.8 -0.9 -0.5 -2.0 -1.3
Shortness of breath walking on level ground 0.5 0.5 1.9 1.4 -0.5 -0.7 0.5 -0.6 0.2 1.2 -0.2 0.0 -0.6 -0.9 0.5 -0.5 -0.8 -1.0 1.0 0.2
Qualifications: College or University degree 0.3 0.8 3.3 0.5 -0.3 -1.8 1.4 1.4 0.3 0.6 0.3 0.9 1.6 1.3 0.2 0.4 0.1 -0.1 0.4 0.3
Eye problems/disorders: None of the above 2.1 2.4 6.9 -1.2 -1.0 -0.4 1.4 -1.3 -2.2 -1.2 -1.2 -1.2 -0.9 0.3 -1.6 -2.3 -2.6 -2.6 -1.0 -1.4
Mouth/teeth dental problems: Loose teeth 0.9 1.1 2.9 -1.3 -0.5 -1.7 -0.5 -1.1 -1.0 -0.7 0.1 -1.6 -1.3 1.4 -1.3 0.4 0.5 -0.1 -1.4 -0.2
Emphysema/chronic bronchitis 0.6 0.6 2.3 -0.8 -1.2 -0.2 -0.0 0.0 -0.4 -1.5 -0.6 -0.7 -1.3 0.6 -0.8 -0.1 0.3 1.1 -1.0 -0.7
Medication for pain relief, constipation, heartburn 0.7 1.1 4.5 1.3 0.2 1.5 -1.2 1.2 0.1 1.0 -0.3 0.5 0.5 -2.1 0.5 -0.2 -1.3 -1.9 0.7 0.4
Neck or shoulder pain in last month 2.0 2.9 7.5 -1.9 -1.2 -0.4 -2.5 -2.1 -2.0 -1.5 -1.1 -2.1 -2.7 0.9 -1.7 -1.2 -1.5 -0.5 -1.9 -1.6
Medication: Blood pressure 0.5 0.9 2.8 -0.8 -0.4 -1.4 -0.8 -1.2 -0.9 -0.8 0.5 -0.8 -1.7 1.1 -0.9 -0.9 -0.3 -0.2 -0.4 -1.3
Angina (self-reported) 0.2 0.3 1.0 0.2 0.5 1.0 -0.4 -0.4 -0.2 0.0 0.5 -0.5 -1.0 -0.1 -0.3 -0.7 0.7 0.6 -0.7 -0.4
Migraine (self-reported) 3.5 4.3 10.9 -1.8 -2.2 -1.0 -0.8 -1.7 -2.5 -2.0 -1.3 -3.0 -3.3 2.7 -2.7 -2.1 -0.5 -0.9 -2.1 -2.2
Medication: Ibuprofen 1.3 1.5 3.8 -1.9 -0.5 -0.8 -0.6 -1.4 -1.2 -1.7 -1.6 -1.1 -1.0 1.9 -1.3 -1.0 0.1 0.7 -1.3 -1.3
Medication: Allopurinol 1.2 1.6 3.8 1.1 1.9 1.5 1.3 0.8 1.1 1.6 1.2 1.9 1.5 -1.4 1.4 0.7 0.2 -0.1 1.3 0.9
Medication: Omeprazole 1.1 1.3 3.9 -1.2 -1.1 0.3 0.9 0.7 -0.6 -1.3 0.7 -1.1 0.4 1.1 -1.3 -0.0 2.0 1.8 -1.9 -0.2
Medication: Seretide 50 evohaler 0.1 0.1 1.2 0.2 0.1 -0.1 -0.1 0.7 0.2 -0.1 0.4 -0.1 -0.1 0.1 -0.0 0.3 1.1 0.4 0.3 0.2
Mean time to correctly identify matches 0.3 0.5 4.7 0.1 -0.0 0.7 -2.2 0.2 -0.2 -0.6 0.2 -0.6 -1.1 -0.9 -0.3 0.0 0.3 -0.5 0.1 0.4
Heart disease (mother) 0.4 0.5 2.1 -0.4 -0.4 -1.3 0.1 -1.3 -0.6 -0.7 -0.9 -0.9 0.1 0.3 -0.2 -0.1 -1.4 -0.2 0.0 -0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.2 1.4 4.6 -0.7 1.2 0.6 1.9 0.0 1.2 0.1 2.1 1.3 1.2 -0.7 1.3 1.8 0.2 0.6 0.5 1.6
Whole body fat mass 0.2 0.7 2.8 -0.6 0.5 0.1 0.5 -1.7 -1.2 -0.1 -0.2 -0.5 1.7 -0.4 -1.0 -0.5 0.1 -1.4 -0.8 -0.8
Leg fat mass (right) 0.2 0.6 3.8 -0.9 0.5 0.4 0.4 -1.3 -1.0 -0.1 -0.3 -0.1 2.0 -0.4 -0.7 -0.2 -0.2 -0.9 -1.0 -0.4
Arm predicted mass (right) 5.7 29.2 54.5 -5.6 -6.4 -3.3 -2.0 -4.6 -7.2 -4.8 -5.5 -6.2 -6.0 3.6 -7.2 -6.1 -2.6 -2.8 -7.4 -6.1
Pulse rate, automated reading 0.2 0.6 2.2 -0.5 -0.4 -0.2 -0.4 -0.3 -0.7 -0.8 -1.1 -0.5 -1.2 1.5 -0.8 -0.6 0.0 0.9 -0.7 -0.8
Alcohol intake frequency. 0.3 0.8 4.1 0.4 -0.2 1.7 -0.6 1.4 0.7 0.0 -0.1 0.0 0.8 -0.4 -0.1 -0.0 2.0 1.5 -0.1 0.2
Comparative height size at age 10 6.3 34.9 64.8 -5.7 -6.8 -4.7 -2.8 -6.2 -7.4 -5.5 -8.1 -6.4 -5.8 3.8 -6.9 -6.3 -4.8 -2.4 -6.6 -7.0
Number of full sisters 0.5 0.6 2.5 0.1 0.7 0.4 1.6 1.4 0.0 -0.3 1.6 -0.2 -1.0 -0.6 -0.0 0.1 -0.3 -0.6 0.3 0.3
Suffer from ‘nerves’ 0.5 0.8 3.7 -0.2 -1.3 -1.3 -1.5 0.2 -0.2 -0.4 -0.9 -0.7 -1.9 1.3 -0.2 -0.2 0.3 -0.2 -0.0 0.6
Overall health rating 1.3 2.8 9.7 -1.1 -1.0 -0.6 -1.3 -1.5 -1.3 -2.1 -1.3 -2.4 -3.1 1.9 -1.8 -1.8 0.6 0.6 -2.1 -1.6
Chest pain or discomfort 0.9 1.2 3.2 -0.6 -1.7 0.3 -1.1 -0.6 -1.4 -1.7 -1.8 -1.0 -1.4 -0.4 -1.2 -1.0 -0.6 -0.4 -0.9 -1.0
Had major operations 1.5 1.7 7.8 1.0 0.6 1.1 2.8 2.5 0.7 1.0 1.8 0.7 0.3 -2.2 0.6 0.4 1.2 0.1 0.3 1.0
Age at last live birth 0.4 0.6 1.7 0.7 1.3 -0.3 -1.0 -0.1 0.8 1.0 -0.5 1.2 0.9 0.7 1.0 0.3 -0.0 0.6 0.8 0.5
Family relationship satisfaction 0.7 0.8 3.8 -0.7 -1.0 -1.0 1.4 0.1 0.4 -0.2 -1.4 0.4 1.1 1.0 0.5 1.1 -0.3 1.9 -0.5 0.4
Leg pain on walking 0.5 0.6 2.2 1.0 -0.2 -1.0 1.0 1.2 0.4 0.8 0.4 0.3 -0.0 -0.3 0.3 0.6 0.5 -1.5 0.4 1.4
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.8 -0.9 -0.7 0.1 0.7 -0.6 -0.5 -0.1 0.2 -0.4 -0.0 -0.3 -0.3 -0.7 -0.6 -0.1 -0.7 -0.4
Commuting to job workplace: Car/motor vehicle 0.6 0.7 2.7 0.8 -0.1 -0.4 0.6 -0.9 0.2 0.4 0.0 0.3 0.5 -1.1 0.7 0.6 -1.6 -1.3 1.6 0.4
Illness, injury, bereavement, stress in last 2 years 3.1 3.8 6.4 1.9 1.9 2.2 0.9 1.8 2.3 2.5 2.2 2.5 1.8 -2.1 2.4 1.9 0.8 0.6 2.4 1.7
Medication: Aspirin 0.8 1.1 3.6 -0.6 0.2 -1.9 0.5 -1.6 -0.9 -0.6 0.1 -0.9 -0.5 1.8 -0.9 -1.6 -0.1 -0.2 -0.8 -1.5
Supplements: Vitamin C 1.4 1.6 4.1 -0.7 -1.3 -0.3 -1.4 -0.8 -1.2 -1.5 -1.2 -2.0 -2.0 1.1 -1.7 -1.1 0.5 -0.5 -1.6 -0.9
Knee pain experienced in last month 0.3 0.5 2.8 -0.3 0.0 1.7 -1.1 0.7 0.1 -0.2 0.8 -0.6 -0.5 -0.4 -0.3 0.1 0.5 -0.7 -0.7 0.5
Hypertension (Self-reported) 0.2 0.5 1.9 0.6 1.0 -0.0 -0.3 -1.3 0.4 1.4 1.3 0.3 0.5 0.4 0.3 0.3 0.9 -0.1 0.5 0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.7 2.0 4.9 -1.5 -1.7 -0.8 1.2 -0.1 -2.1 -1.5 -1.4 -1.9 -1.0 1.2 -2.2 -1.3 -0.7 -0.2 -1.4 -1.8
Illnesses of father: Heart disease 0.3 0.4 2.5 -0.0 -1.0 -1.6 0.5 0.1 -0.4 -0.5 -0.2 -0.7 -0.5 0.7 -0.4 -0.5 -0.6 -0.3 0.3 -0.7
Illnesses of siblings: Diabetes 0.4 0.5 2.6 0.4 -0.3 -1.5 -0.8 -0.8 0.5 0.8 -0.0 0.0 0.3 1.6 0.1 0.1 0.8 -0.0 0.4 0.4
Smoking status: Previous 1.2 1.7 4.8 -2.0 -1.3 -1.1 1.5 0.0 -1.4 -1.3 -0.5 -1.0 -1.4 2.1 -1.6 -0.6 -0.2 0.9 -2.2 -1.1
Forced expiratory volume in 1-second (FEV1), predicted 5.4 11.2 24.8 -3.9 -4.2 -2.5 -1.3 -4.3 -3.9 -3.4 -5.0 -2.9 -3.6 1.8 -3.5 -3.0 -2.8 -1.1 -3.5 -3.5
Whole body fat-free mass 6.1 34.7 61.5 -5.8 -6.9 -3.8 -2.5 -5.5 -7.7 -5.0 -6.3 -6.8 -6.4 3.9 -7.8 -6.7 -2.8 -3.1 -7.8 -6.7
Leg fat-free mass (right) 4.8 25.5 47.2 -5.0 -5.7 -3.1 -1.9 -4.8 -6.7 -4.4 -5.0 -6.1 -5.4 3.4 -6.9 -5.9 -2.0 -2.8 -6.7 -5.8
Arm fat percentage (left) 1.4 5.4 19.1 2.2 3.3 2.0 1.4 0.9 2.1 2.4 2.5 2.3 4.4 -2.4 2.2 2.2 1.9 -0.3 2.4 2.2
Average weekly red wine intake 0.4 0.5 2.4 -0.6 -0.3 0.5 0.3 0.5 -0.9 -0.2 0.2 -0.5 -1.2 0.0 -0.9 -1.5 -0.4 -0.6 -1.2 -0.6
Handedness (chirality/laterality): Left-handed 0.9 1.1 3.4 -0.1 -1.7 -0.0 -0.8 -1.8 -1.2 0.2 -1.1 -0.7 -1.2 -0.5 -0.7 -0.9 -1.9 -0.7 -0.3 -1.3
Mood swings 0.8 1.5 4.8 0.5 1.4 0.7 0.1 1.4 1.8 0.6 1.0 1.8 -0.0 0.5 1.7 0.9 1.2 2.2 1.0 1.3
Loneliness, isolation 0.4 0.5 3.0 -0.4 -0.7 0.0 0.5 0.2 -0.1 -0.8 -0.7 -0.2 -1.6 0.4 -0.2 0.2 0.4 1.7 -0.5 0.0
Long-standing illness, disability or infirmity 0.2 0.3 1.3 0.5 -0.3 0.1 0.4 0.8 0.6 -0.2 -0.5 0.3 -0.9 -1.1 0.6 -0.1 -0.7 0.2 1.0 -0.3
Ever had bowel cancer screening 0.8 0.9 3.6 -1.9 -0.2 1.0 0.7 0.6 -0.7 -1.7 0.3 -0.7 -0.5 0.2 -1.0 0.6 0.5 1.3 -1.6 -0.2
Diabetes diagnosed by doctor 0.8 1.3 4.6 2.1 0.8 0.7 -1.5 -2.1 0.6 1.9 0.0 0.6 0.1 -0.6 0.9 -0.2 -0.1 -0.3 1.8 -0.1
Ever had stillbirth, spontaneous miscarriage or termination 1.2 1.3 2.4 0.8 1.2 1.4 0.1 1.6 1.0 0.9 1.0 1.3 1.2 -1.2 0.8 1.5 1.4 0.1 0.6 1.4
Friendships satisfaction 2.7 3.3 6.2 -1.9 -2.3 -1.5 -0.1 -1.7 -1.9 -1.9 -2.5 -1.7 -2.2 2.1 -1.6 -1.9 -1.8 -0.1 -2.2 -1.7
Qualifications: nursing, teaching 2.2 3.4 8.8 2.5 1.3 0.3 1.5 2.5 2.1 2.6 1.4 2.2 3.0 -0.8 2.1 1.0 0.5 -0.3 2.0 1.9
Commuting to job workplace: Walk 0.8 0.8 2.5 -0.4 1.0 1.2 -0.3 0.6 -0.4 0.4 0.7 -0.1 0.2 0.7 -1.1 -1.5 1.5 0.5 -1.6 -1.2
Eye problems/disorders: Cataract 0.4 0.4 1.8 0.4 0.7 -0.2 -1.3 0.1 0.7 0.4 0.0 0.6 -0.1 0.1 0.4 0.5 1.1 1.3 0.6 -0.0
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 1.8 -0.7 -1.2 -0.5 1.4 1.0 -0.2 -0.8 0.4 -0.4 -0.5 0.6 -0.4 -0.3 0.6 1.1 -1.4 0.1
Medication for cholesterol 0.9 1.4 4.2 -1.0 -2.0 -1.0 -1.4 0.4 -0.4 -1.6 -2.0 -0.4 -0.8 1.5 -0.5 -0.5 -0.2 1.8 -0.9 -0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.5 1.9 0.5 0.3 0.3 1.4 0.1 0.9 0.3 0.9 0.8 0.0 -1.0 0.7 0.9 0.7 0.3 0.9 0.9
Back pain experienced in last month 1.5 2.2 5.2 -1.7 -2.2 -1.5 -1.2 -1.2 -1.4 -1.6 -1.6 -2.3 -1.9 0.2 -1.9 -1.2 0.4 -0.1 -1.7 -0.9
Mineral and other dietary supplements 0.6 0.7 5.2 -0.7 -0.2 2.3 0.2 -1.2 0.1 -0.2 -0.1 0.5 0.9 -1.5 0.6 0.7 -0.9 -0.1 0.4 0.4
Breast cancer (self-reported) 0.8 1.0 2.4 1.5 1.1 -0.2 -0.0 0.2 1.2 1.2 1.1 1.4 1.4 -0.1 1.2 0.6 0.2 -0.1 1.4 0.8
Asthma (self-reported) 0.5 1.0 5.7 1.2 -0.5 -1.3 2.4 0.8 0.8 0.4 0.1 0.3 1.1 -1.1 1.0 0.7 0.3 0.2 1.0 1.4
Osteoporosis (self-reported) 0.8 1.0 4.9 1.4 0.9 1.7 -0.6 2.2 0.5 0.5 1.2 1.1 0.7 -1.4 0.4 -0.4 0.5 -0.4 0.4 0.2
Osteoarthritis (self-reported) 1.0 1.3 3.7 -0.1 -0.9 0.9 -1.6 -0.0 -1.0 -0.9 0.7 -1.2 -1.2 -1.8 -0.7 -1.7 -1.4 -1.9 -0.5 -1.0
Medication: Aspirin 0.7 1.0 3.5 -0.6 0.3 -1.5 0.4 -1.6 -0.8 -0.5 0.1 -0.9 -0.6 1.9 -0.8 -1.5 -0.2 -0.1 -0.8 -1.3
Medication: Gliclazide 0.5 0.6 1.9 0.6 0.8 0.2 -1.2 -1.3 0.7 1.0 0.6 0.4 1.4 -0.6 0.6 0.3 1.0 0.4 0.7 0.3
Illnesses of father: None of the above (group 1) 0.6 0.8 2.7 -0.0 0.2 1.6 1.5 1.6 0.6 -0.3 0.5 0.4 0.2 -0.9 0.3 1.0 0.9 0.8 1.0 0.6
Smoking status: Current 0.3 0.6 2.8 0.2 -0.1 0.1 -0.8 -1.0 -0.1 0.0 -1.7 0.0 -0.3 -0.6 0.5 -0.3 -1.7 0.7 0.6 -0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.7 2.5 0.7 -0.9 1.2 1.3 0.0 0.2 0.6 0.1 0.1 -0.2 -1.6 0.3 0.8 -0.1 -1.4 0.8 0.8
Whole body water mass 6.0 34.3 60.8 -5.7 -6.9 -3.8 -2.4 -5.4 -7.7 -5.0 -6.2 -6.8 -6.3 3.9 -7.7 -6.7 -2.9 -3.2 -7.8 -6.7
Leg predicted mass (right) 4.9 26.0 48.7 -5.1 -5.7 -3.0 -1.9 -4.9 -6.8 -4.4 -5.0 -6.2 -5.4 3.5 -7.0 -6.0 -2.0 -2.9 -6.8 -5.9
Arm fat mass (left) 0.1 0.5 2.2 -0.2 0.3 0.4 0.3 -1.1 -0.9 0.2 -0.1 -0.4 1.5 -0.5 -0.8 -0.3 0.5 -1.3 -0.7 -0.4
Number of self-reported non-cancer illnesses 1.0 1.7 4.1 -1.2 -1.7 -0.8 -0.5 -1.6 -1.3 -1.3 -1.1 -2.0 -2.0 1.4 -1.7 -0.7 0.5 0.0 -1.2 -1.0
Average weekly champagne plus white wine intake 0.5 0.7 3.8 -0.6 -0.4 -0.9 -0.5 0.0 -0.5 -0.5 -0.6 -0.6 0.4 1.5 -0.9 -0.7 1.3 0.7 -2.0 -0.3
Miserableness 0.5 0.8 4.2 -0.9 0.2 0.9 -0.4 -0.2 0.1 -0.8 0.4 -0.1 -1.9 1.4 -0.1 0.6 0.8 2.0 0.0 0.3
Guilty feelings 0.4 0.7 3.2 1.3 0.4 0.4 1.0 0.9 0.4 1.5 1.8 0.7 -0.7 -0.5 0.3 -0.4 0.7 0.3 0.3 0.2
Wears glasses or contact lenses 1.7 1.9 4.4 1.7 1.8 1.8 0.3 1.2 1.7 1.2 1.4 1.3 2.1 -1.2 1.5 1.1 1.1 0.2 1.2 1.5
Ever taken oral contraceptive pill 0.2 0.2 2.0 -0.2 -0.1 -0.7 -0.3 -0.1 -0.2 -0.2 -1.4 0.4 -0.6 0.2 -0.0 0.5 -0.5 -0.2 0.4 0.1
Hearing aid user 0.8 0.9 4.7 0.1 -0.2 1.4 2.2 1.8 0.6 -0.3 0.5 -0.1 0.3 -0.7 0.2 0.5 1.7 0.9 -0.2 0.8
Mother’s age at death 0.7 0.9 2.6 1.6 0.8 0.6 -1.0 0.4 1.2 0.6 0.4 0.4 1.6 -0.5 0.8 0.5 1.4 -0.6 0.2 1.4
Financial situation satisfaction 1.6 2.0 5.5 -2.3 -1.0 -1.2 0.0 -0.2 -1.1 -2.1 -1.1 -1.2 -1.6 1.1 -1.3 -0.8 0.5 2.1 -2.3 -1.3
Tinnitus: Yes, now most or all of the time 1.3 1.5 9.2 -0.2 -2.3 -3.0 0.2 -1.0 -0.3 -0.1 -1.9 -0.5 -1.3 1.4 -0.1 -0.2 -1.2 -0.0 0.6 -0.6
Commuting to job workplace: Public transport 1.1 1.4 3.2 1.4 1.5 0.1 1.4 1.0 1.1 1.2 1.8 1.3 1.7 -1.4 1.3 0.1 0.3 -0.5 0.8 1.0
Eye problems/disorders: Glaucoma 0.8 1.0 3.4 1.5 0.4 1.3 -1.8 -0.1 0.8 1.8 0.3 0.8 0.4 -1.8 0.7 0.3 0.3 -0.4 0.7 0.3
Medication: Blood pressure 0.5 1.0 4.5 0.6 1.4 -0.1 1.2 -0.8 0.5 2.1 1.9 0.4 1.4 0.5 0.3 0.5 0.9 -0.5 0.3 0.7
Pain type(s) experienced in last month: Hip pain 3.5 4.4 22.6 -0.2 1.0 0.9 4.8 2.9 1.5 0.7 3.3 1.4 2.2 -1.3 1.1 2.4 2.1 1.6 0.7 2.1
Supplements: Fish oil (including cod liver oil) 0.3 0.4 2.3 0.2 0.7 -1.2 -1.0 0.7 0.2 -0.0 -0.2 -0.2 0.2 1.5 -0.2 0.0 0.7 0.9 -0.6 0.0
High cholesterol (Self-reported) 0.6 1.1 4.9 0.7 1.3 1.1 2.2 0.4 0.6 0.7 2.2 0.3 0.1 0.0 0.2 0.4 1.6 0.4 0.7 0.4
Medication: Bendroflumethiazide 0.2 0.2 1.5 -0.1 1.2 0.0 -0.2 -0.9 -0.2 0.8 0.6 0.1 0.4 0.3 -0.1 -0.2 -0.2 -0.4 -0.1 -0.3
Medication: Paracetamol 1.3 2.0 4.8 -2.2 -1.3 -0.5 -0.5 -1.9 -1.0 -1.7 -0.9 -1.6 -2.0 2.1 -1.5 -0.3 0.7 1.2 -1.7 -1.1
Medication: Lisinopril 2.0 2.6 4.9 -1.9 -1.3 -1.5 -0.7 -0.8 -1.8 -2.1 -1.5 -2.0 -2.2 1.4 -1.6 -1.1 -1.9 -1.0 -1.6 -1.7
Medication: Atorvastatin 4.0 5.0 14.6 2.4 2.3 1.4 3.2 2.6 2.3 2.5 3.8 2.2 1.0 -1.0 2.2 1.9 1.8 0.6 2.4 1.9
Illnesses of father: High blood pressure 2.1 2.5 6.4 -0.7 -1.5 -2.5 -0.5 -1.9 -1.8 -0.2 -1.4 -1.4 -1.8 2.0 -1.6 -2.3 -1.3 -1.2 -1.1 -1.9
Alcohol drinker status: Never 0.8 1.0 4.6 -0.9 -1.0 -0.3 0.2 -0.5 -0.8 -0.8 0.1 -2.2 0.2 1.5 -1.5 -1.0 1.0 -0.5 -1.1 -0.6
Ever smoked 2.1 3.7 6.4 -2.4 -2.1 -1.9 0.3 -0.9 -2.1 -1.9 -2.0 -1.7 -2.5 2.5 -2.0 -1.7 -1.5 1.2 -2.5 -2.1
Basal metabolic rate 4.9 27.1 48.3 -5.1 -6.1 -3.3 -2.1 -5.0 -6.9 -4.4 -5.7 -6.1 -5.3 3.4 -6.9 -6.0 -2.4 -2.9 -7.0 -5.9
Leg fat percentage (left) 2.0 7.1 27.1 2.2 3.8 1.9 1.5 1.2 2.4 2.8 2.9 3.1 5.2 -2.5 2.7 2.6 1.5 -0.1 2.5 2.6
Arm fat-free mass (left) 5.7 28.9 51.8 -5.4 -6.2 -3.5 -2.4 -5.2 -7.2 -4.6 -5.6 -6.2 -5.4 3.3 -7.1 -6.1 -3.0 -3.2 -7.1 -6.2
Number of operations (self-reported) 0.8 1.3 5.5 0.7 1.2 -1.3 1.1 1.1 1.2 0.9 2.4 0.4 0.5 -0.9 0.9 1.2 1.3 0.1 0.5 1.4
Average weekly beer plus cider intake 0.5 0.7 4.3 0.6 0.2 0.1 0.6 -0.1 0.4 0.0 0.9 -0.1 -0.9 -2.1 0.8 0.2 -0.6 -1.7 0.8 0.9
Irritability 0.9 1.6 5.6 -1.7 -1.8 -2.1 0.4 -0.7 -0.8 -2.4 -0.8 -1.2 -1.9 1.5 -0.7 -0.3 -0.2 0.1 -0.7 -0.2
Risk taking 0.3 0.5 4.4 -0.8 -0.5 -0.8 2.1 -0.4 -0.4 -0.8 -0.3 -0.1 0.4 -0.6 -0.4 0.1 -0.1 -0.2 -0.2 -0.0
Ever had prostate specific antigen (PSA) test 0.9 1.0 2.4 0.3 1.6 0.1 1.1 1.0 1.1 1.0 1.1 1.4 0.3 0.4 1.2 1.3 0.5 1.2 0.9 1.0
Fractured/broken bones in last 5 years 0.6 0.8 2.8 -0.7 -0.7 -1.2 -0.6 -0.6 -0.6 0.4 -0.9 -0.6 -0.4 1.7 -0.9 0.2 0.9 1.5 -1.1 -0.5
Age started oral contraceptive pill 0.2 0.3 1.5 0.4 1.2 0.6 -0.3 0.2 0.1 -0.0 0.7 0.0 1.1 0.5 -0.2 -0.6 0.4 -0.0 -0.4 -0.4
Diastolic blood pressure, automated reading 14.7 45.5 73.4 -6.5 -7.4 -5.6 -3.7 -6.1 -8.6 -6.6 -7.2 -8.1 -7.1 5.2 -8.2 -7.5 -5.2 -4.3 -6.9 -7.9
Ever depressed for a whole week 0.8 1.0 4.0 -1.4 -1.5 -1.4 -0.1 -0.2 -0.8 -2.0 -0.7 -0.7 -0.1 0.7 -0.9 -0.8 0.0 -0.6 -1.6 -0.1
Unable to work because of sickness or disability 0.4 0.5 2.1 0.8 -0.4 -1.3 -1.4 1.2 -0.0 -0.4 -0.7 -0.2 -1.0 -0.1 -0.4 -0.7 0.5 0.3 -0.7 -0.3
Commuting to job workplace: Cycle 0.1 0.1 0.5 0.3 0.2 -0.0 -0.5 0.3 0.1 0.3 0.7 -0.3 -0.5 0.6 -0.0 0.1 0.2 -0.4 0.1 0.1
Myopia 0.3 0.4 2.7 0.8 -0.6 -0.1 0.3 0.4 -0.2 -0.0 -0.2 -0.2 -0.3 -1.3 -0.0 -1.1 -0.1 -1.7 0.5 0.1
Vascular/heart problems diagnosed by doctor 0.1 0.4 2.4 -0.2 -0.7 0.1 -0.4 1.6 -0.1 -1.0 -1.0 -0.1 -0.3 -0.4 -0.1 -0.1 -0.7 0.2 -0.4 -0.1
Cholesterol lowering medication 1.7 2.5 6.1 1.7 1.7 1.4 1.7 0.9 1.6 1.5 2.5 1.2 2.0 -1.5 1.3 1.5 1.7 0.4 1.8 1.3
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 3.0 -1.4 -0.7 -0.2 1.0 -0.0 -0.7 -1.6 0.4 -1.0 0.0 0.9 -1.2 0.3 1.4 1.7 -1.7 -0.4
Pain experienced in last month 1.5 2.5 7.4 2.4 1.4 0.8 -0.4 0.5 1.9 2.3 0.1 2.2 2.7 -1.0 2.0 0.9 0.6 0.2 1.7 1.6
Supplements: Calcium 1.1 1.2 3.6 -0.4 -1.6 -1.0 0.9 1.1 -0.5 -0.9 -1.9 -0.3 -1.4 1.5 -0.6 -0.4 -0.1 1.8 -1.1 -0.7
Basal cell carcinoma (self-reported) 1.0 1.2 6.7 -1.8 -0.8 0.0 2.6 0.7 -0.7 -1.9 0.5 -1.0 -1.1 0.6 -0.9 -0.1 -0.2 0.3 -1.3 -0.5
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.9 -0.0 0.1 0.7 1.4 0.4 -0.4 0.0 0.6 -0.6 -1.2 -0.1 -0.7 -0.4 0.8 0.2 -0.4 -0.6
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 2.2 0.3 0.1 0.3 -1.0 -0.6 0.3 0.9 -0.0 0.7 1.3 -1.5 0.6 0.0 -0.8 -0.8 -0.3 0.3
Heart disease (siblings) 0.4 0.5 2.3 -0.8 -1.5 -0.5 -0.3 0.1 -0.8 -0.9 -0.8 -0.9 -0.6 0.6 -0.8 -0.5 -0.3 0.3 -0.2 -1.1
Alcohol drinker status: Previous 0.8 0.9 4.7 1.1 -0.1 1.0 -2.2 0.5 0.6 0.3 -1.4 0.3 -0.7 0.2 0.4 0.1 1.1 1.7 0.7 0.2
Pack years of smoking 0.5 0.7 3.1 0.1 -0.9 -1.2 -0.0 -0.2 -0.8 -0.5 -1.0 -1.3 -0.5 -0.3 -0.7 -1.8 -0.6 -0.1 -0.7 -1.3
Impedance of whole body 1.2 6.3 20.8 2.6 3.1 0.8 1.2 0.3 3.2 2.2 1.3 3.1 3.1 -1.5 3.5 3.1 -0.0 1.1 4.6 2.4
Leg fat mass (left) 0.2 0.6 4.3 -0.3 0.7 0.4 0.3 -1.2 -0.8 0.3 0.1 0.0 2.1 -0.7 -0.5 -0.2 0.2 -1.2 -0.8 -0.2
Arm predicted mass (left) 5.4 27.4 48.9 -5.2 -6.1 -3.5 -2.5 -4.9 -7.0 -4.4 -5.5 -6.0 -5.4 3.2 -6.9 -5.9 -2.8 -3.3 -6.9 -6.0