Best TWAS P=1.89e-14 · Best GWAS P=1.23e-17 conditioned to 5.15e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | RP11-819C21.1 | 0.19 | 0.21 | lasso | 5 | 0.20 | 7.4e-16 | -5.3 | -6.0 | 1.5e-09 | -0.57 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | RP11-819C21.1 | 0.19 | 0.17 | enet | 26 | 0.16 | 9.0e-09 | -5.2 | -5.3 | 1.1e-07 | -0.51 | 0.96 | 0.03 | FALSE |
| 3 | GTEx | Artery Aorta | RP11-819C21.1 | 0.13 | 0.07 | lasso | 6 | 0.10 | 3.4e-06 | -3.9 | -5.7 | 1.0e-08 | -0.51 | 0.76 | 0.20 | FALSE |
| 4 | GTEx | Artery Tibial | RP11-819C21.1 | 0.19 | 0.09 | lasso | 8 | 0.09 | 2.3e-07 | -5.3 | -5.9 | 2.9e-09 | -0.53 | 0.84 | 0.15 | FALSE |
| 5 | GTEx | Brain Cerebellar Hemisphere | RP11-819C21.1 | 0.37 | 0.16 | enet | 23 | 0.24 | 8.8e-07 | -1.9 | -5.1 | 3.0e-07 | -0.47 | 0.37 | 0.17 | FALSE |
| 6 | GTEx | Brain Cerebellum | RP11-819C21.1 | 0.18 | 0.08 | enet | 2 | 0.02 | 8.8e-02 | 7.6 | -7.4 | 1.1e-13 | -0.76 | 0.06 | 0.45 | FALSE |
| 7 | GTEx | Brain Nucleus accumbens basal ganglia | RP11-819C21.1 | 0.39 | 0.17 | enet | 26 | 0.23 | 1.0e-06 | -5.2 | -6.5 | 5.7e-11 | -0.61 | 0.14 | 0.79 | FALSE |
| 8 | GTEx | Breast Mammary Tissue | RP11-819C21.1 | 0.14 | 0.09 | enet | 12 | 0.09 | 2.6e-05 | 7.6 | -7.0 | 3.3e-12 | -0.67 | 0.16 | 0.78 | FALSE |
| 9 | GTEx | Breast Mammary Tissue (Male) | RP11-819C21.1 | 0.15 | -0.01 | lasso | 1 | -0.01 | 7.0e-01 | 7.6 | -7.6 | 2.1e-14 | -0.80 | 0.04 | 0.19 | FALSE |
| 10 | GTEx | Cells Transformed fibroblasts | CWF19L2 | 0.13 | 0.05 | enet | 19 | 0.06 | 2.6e-05 | 7.6 | 6.0 | 1.7e-09 | 0.65 | 0.78 | 0.18 | FALSE |
| 11 | GTEx | Cells Transformed fibroblasts | RP11-819C21.1 | 0.11 | 0.06 | lasso | 8 | 0.05 | 2.1e-04 | 6.5 | -6.7 | 2.9e-11 | -0.60 | 0.82 | 0.10 | FALSE |
| 12 | GTEx | Colon Sigmoid | RP11-819C21.1 | 0.17 | 0.05 | enet | 20 | 0.08 | 6.4e-04 | -2.6 | -5.7 | 1.6e-08 | -0.50 | 0.41 | 0.42 | FALSE |
| 13 | GTEx | Esophagus Gastroesophageal Junction | CWF19L2 | 0.16 | 0.06 | lasso | 3 | 0.04 | 1.1e-02 | -4.6 | 5.4 | 5.9e-08 | 0.47 | 0.17 | 0.48 | FALSE |
| 14 | GTEx | Esophagus Mucosa | CWF19L2 | 0.20 | 0.14 | lasso | 5 | 0.12 | 3.4e-08 | -4.0 | 5.2 | 1.6e-07 | 0.55 | 0.90 | 0.10 | FALSE |
| 15 | GTEx | Esophagus Mucosa | RP11-819C21.1 | 0.20 | 0.18 | enet | 21 | 0.20 | 3.6e-13 | -5.3 | -5.4 | 6.5e-08 | -0.49 | 0.98 | 0.02 | FALSE |
| 16 | GTEx | Heart Left Ventricle | CWF19L2 | 0.10 | 0.07 | lasso | 4 | 0.05 | 1.4e-03 | 6.2 | 7.2 | 4.1e-13 | 0.69 | 0.55 | 0.16 | FALSE |
| 17 | GTEx | Heart Left Ventricle | RP11-819C21.1 | 0.13 | 0.04 | lasso | 3 | 0.04 | 4.6e-03 | -5.3 | -5.7 | 1.4e-08 | -0.49 | 0.03 | 0.86 | FALSE |
| 18 | GTEx | Lung | CWF19L2 | 0.19 | 0.12 | lasso | 7 | 0.13 | 7.8e-10 | -4.6 | 5.8 | 5.6e-09 | 0.52 | 0.93 | 0.07 | FALSE |
| 19 | GTEx | Lung | RP11-819C21.1 | 0.09 | 0.07 | lasso | 6 | 0.07 | 2.6e-06 | -6.9 | -6.8 | 1.4e-11 | -0.65 | 0.04 | 0.94 | FALSE |
| 20 | GTEx | Muscle Skeletal | CWF19L2 | 0.08 | 0.05 | lasso | 3 | 0.05 | 1.1e-05 | 7.6 | 7.7 | 1.9e-14 | 0.80 | 0.04 | 0.96 | TRUE |
| 21 | GTEx | Nerve Tibial | RP11-819C21.1 | 0.40 | 0.24 | enet | 46 | 0.39 | 2.1e-29 | -5.1 | -6.7 | 2.0e-11 | -0.66 | 0.99 | 0.01 | FALSE |
| 22 | GTEx | Ovary | RP11-819C21.1 | 0.31 | 0.11 | enet | 28 | 0.22 | 3.9e-06 | 5.5 | -5.9 | 4.6e-09 | -0.69 | 0.06 | 0.84 | FALSE |
| 23 | GTEx | Skin Not Sun Exposed Suprapubic | CWF19L2 | 0.18 | 0.12 | enet | 22 | 0.10 | 2.5e-06 | -4.0 | 5.5 | 3.6e-08 | 0.58 | 0.89 | 0.11 | FALSE |
| 24 | GTEx | Skin Not Sun Exposed Suprapubic | RP11-819C21.1 | 0.27 | 0.10 | lasso | 5 | 0.19 | 9.4e-11 | -5.3 | -7.3 | 3.0e-13 | -0.81 | 0.01 | 0.99 | FALSE |
| 25 | GTEx | Skin Sun Exposed Lower leg | RP11-819C21.1 | 0.28 | 0.23 | enet | 33 | 0.24 | 4.8e-20 | -5.3 | -6.3 | 2.3e-10 | -0.60 | 1.00 | 0.00 | FALSE |
| 26 | GTEx | Stomach | RP11-819C21.1 | 0.10 | 0.01 | lasso | 4 | 0.03 | 9.9e-03 | -4.0 | -5.6 | 1.8e-08 | -0.56 | 0.24 | 0.29 | FALSE |
| 27 | GTEx | Testis | CWF19L2 | 0.20 | 0.09 | lasso | 6 | 0.09 | 1.0e-04 | 7.6 | 7.5 | 7.3e-14 | 0.72 | 0.49 | 0.22 | FALSE |
| 28 | GTEx | Thyroid | RP11-819C21.1 | 0.14 | 0.11 | enet | 21 | 0.13 | 3.0e-10 | -5.3 | -6.0 | 1.5e-09 | -0.62 | 0.46 | 0.54 | FALSE |
| 29 | GTEx | Whole Blood | RP11-819C21.1 | 0.06 | 0.03 | lasso | 2 | 0.01 | 4.8e-02 | 5.5 | -5.6 | 2.3e-08 | -0.53 | 0.16 | 0.27 | FALSE |
| 30 | METSIM | Adipose | CWF19L2 | 0.08 | 0.03 | blup | 517 | 0.05 | 6.5e-08 | 7.6 | 5.3 | 9.3e-08 | 0.62 | 0.70 | 0.30 | FALSE |
| 31 | YFS | Blood | CWF19L2 | 0.26 | 0.16 | enet | 101 | 0.22 | 2.2e-68 | 7.6 | 5.2 | 2.4e-07 | 0.61 | 0.60 | 0.40 | FALSE |
| 32 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CWF19L2 | 0.16 | 0.04 | blup | 106 | 0.09 | 1.4e-18 | 4.4 | 5.6 | 2.5e-08 | 0.51 | 1.00 | 0.00 | FALSE |
| 33 | The Cancer Genome Atlas | Colon Adenocarcinoma | CWF19L2 | 0.11 | 0.01 | blup | 105 | 0.02 | 3.0e-02 | -3.9 | 6.7 | 1.8e-11 | 0.62 | 0.06 | 0.09 | FALSE |
| 34 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CWF19L2 | 0.05 | 0.00 | blup | 106 | 0.01 | 3.4e-02 | 2.9 | 6.3 | 2.7e-10 | 0.71 | 0.03 | 0.05 | FALSE |
| 35 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CWF19L2 | 0.08 | 0.00 | blup | 106 | 0.03 | 3.0e-04 | -3.4 | 5.4 | 8.0e-08 | 0.66 | 0.40 | 0.07 | FALSE |
| 36 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CWF19L2 | 0.10 | 0.03 | lasso | 4 | 0.07 | 1.2e-07 | 5.4 | 5.4 | 7.0e-08 | 0.55 | 0.20 | 0.71 | FALSE |
| 37 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | CWF19L2 | 0.13 | 0.01 | enet | 9 | 0.04 | 1.4e-02 | -5.1 | 6.5 | 8.5e-11 | 0.65 | 0.02 | 0.41 | FALSE |