Best TWAS P=3.53e-39 · Best GWAS P=1.64e-34 conditioned to 0.969
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ARHGAP42 | 0.08 | 0.03 | enet | 14 | 0.05 | 2.8e-06 | -8.4 | -8.0 | 1.2e-15 | 0.50 | 0.98 | 0.01 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | TMEM133 | 0.05 | 0.01 | bslmm | 541 | 0.02 | 4.7e-03 | -8.4 | -6.5 | 7.5e-11 | 0.31 | 0.14 | 0.11 | FALSE |
| 3 | GTEx | Artery Aorta | ARHGAP42 | 0.22 | 0.15 | enet | 18 | 0.19 | 1.7e-10 | -12.2 | -11.5 | 1.0e-30 | 0.86 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Artery Aorta | TMEM133 | 0.30 | 0.15 | enet | 34 | 0.19 | 7.1e-11 | -12.3 | -10.9 | 1.6e-27 | 0.72 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Artery Tibial | ARHGAP42 | 0.24 | 0.24 | lasso | 4 | 0.24 | 2.4e-18 | -12.3 | -12.5 | 5.5e-36 | 0.98 | 0.00 | 1.00 | FALSE |
| 6 | GTEx | Artery Tibial | TMEM133 | 0.26 | 0.25 | enet | 28 | 0.27 | 1.3e-21 | -12.3 | -13.1 | 3.5e-39 | 0.94 | 0.00 | 1.00 | TRUE |
| 7 | GTEx | Cells Transformed fibroblasts | ARHGAP42 | 0.15 | 0.10 | enet | 20 | 0.08 | 2.6e-06 | 4.5 | -6.9 | 3.8e-12 | 0.46 | 0.59 | 0.36 | FALSE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | ARHGAP42 | 0.04 | 0.00 | lasso | 2 | 0.00 | 1.9e-01 | -8.3 | -7.9 | 3.4e-15 | 0.51 | 0.11 | 0.22 | FALSE |
| 9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ARHGAP42 | 0.04 | 0.01 | blup | 266 | 0.02 | 1.1e-04 | 7.9 | -8.7 | 3.7e-18 | 0.57 | 0.05 | 0.87 | FALSE |