Best TWAS P=2.58e-11 · Best GWAS P=1.24e-15 conditioned to 8.79e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | ROSMAP | Brain Pre-frontal Cortex | ADAMTS8 | 0.12 | 0.09 | lasso | 5 | 0.08 | 4.0e-10 | 5.0 | 5.1 | 2.8e-07 | 0.43 | 1.00 | 0.00 | FALSE |
| 2 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ADAMTS8 | 0.06 | 0.02 | lasso | 3 | 0.02 | 1.0e-03 | 7.8 | -6.5 | 1.1e-10 | -0.87 | 0.01 | 0.94 | FALSE |
| 3 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ADAMTS8 | 0.04 | 0.03 | enet | 8 | 0.03 | 8.5e-05 | 7.8 | -6.7 | 2.6e-11 | -0.80 | 0.00 | 0.92 | TRUE |