TWAS hub - ADAMTS8

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1540	0.0360	1.1e-07	0.076	0.050	0.070	0.037	0.048	1.4e-09	8.5e-07	6.5e-09	2.1e-05	1.5e-06
2	ROSMAP	Brain Pre-frontal Cortex	0.1250	0.0331	2.7e-06	0.086	0.039	0.075	0.067	0.077	3.2e-11	8.2e-06	5.9e-10	5.9e-09	4.0e-10
3	TCGA	Head and Neck Squamous Cell Carcinoma	0.0554	0.0265	3.3e-03	0.019	0.005	0.014	NA	0.023	2.6e-03	8.2e-02	9.3e-03	NA	1.0e-03
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0423	0.0218	4.7e-03	0.033	0.029	0.034	NA	0.033	1.2e-04	2.7e-04	8.5e-05	NA	1.3e-04
5	TCGA	Prostate Adenocarcinoma	0.0697	0.0295	3.8e-03	0.027	0.021	0.012	NA	0.017	7.4e-04	2.4e-03	1.7e-02	NA	6.6e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Diastolic blood pressure, automated reading	10.8	33.6	65.6	-4.2	-5.3	8.1	6.8	3.3
Systolic blood pressure, automated reading	9.2	26.8	44.5	2.8	5.1	-6.5	-6.7	-3.7
Pulse wave reflection index	8.7	10.8	22.0	-1.6	-1.8	4.5	4.7	2.4
Systolic Blood Pressure	8.2	41.1	66.4	5.0	6.5	-8.2	-7.6	-3.8
Impedance of arm (right)	7.9	36.7	71.6	-2.8	-2.7	8.5	8.2	5.4
Impedance of arm (left)	6.8	31.5	62.0	-2.5	-2.6	7.9	7.7	4.9
Eye problems/disorders: Glaucoma	3.4	4.0	8.9	0.1	0.4	2.8	3.0	1.7
Lung FVC	3.1	16.0	42.4	1.6	6.5	-1.6	-4.9	2.9
Trunk fat percentage	3.1	12.4	31.9	-0.2	1.5	3.8	3.7	5.7
Pulse wave Arterial Stiffness index	3.1	3.6	7.3	-0.6	0.1	2.5	2.7	1.9
Mean time to correctly identify matches	2.9	5.5	8.5	2.8	2.9	-2.4	-2.0	-1.2
Pain all over the body in last month	2.8	3.0	6.5	-2.1	-2.5	1.4	1.4	0.0
Birth weight	2.8	6.1	10.5	-1.7	-1.6	3.2	2.7	2.7
Waist Hip Ratio (WHR)	2.6	11.8	27.6	3.6	2.3	-5.2	-3.2	-1.6
Medication: Simvastatin	2.6	3.9	7.8	2.2	2.8	-1.8	-1.7	0.7
Bipolar Disorder (2011)	2.5	2.5	4.0	-1.5	-2.0	1.7	1.7	0.7
Hearing difficulty/problems: Yes	2.5	3.7	5.7	2.2	2.0	-2.4	-2.0	-0.7
Osteoporosis (self-reported)	2.5	3.0	8.7	0.7	-1.8	-1.3	-1.1	-3.0
Impedance of whole body	2.5	12.8	24.7	-1.4	-1.3	5.0	4.9	3.4
Reaction Time	2.4	4.5	8.8	2.7	3.0	-1.9	-1.7	-0.1
Arm fat percentage (right)	2.4	9.6	26.6	-0.5	1.1	3.5	2.8	5.2
Glaucoma (self-reported)	2.4	2.9	4.7	1.2	1.3	2.2	2.0	1.6
Eye problems/disorders: Diabetes related eye disease	2.3	2.5	6.1	1.0	2.5	0.4	0.3	2.2
Age at First Birth	2.2	3.2	6.0	-1.3	-1.7	2.5	1.9	1.3
Pulse wave peak to peak time	2.2	2.6	4.8	0.5	-0.4	-2.2	-2.2	-1.7
Arm fat percentage (left)	2.2	9.0	26.0	-0.2	1.3	3.3	2.5	5.1
Alzheimer’s Disease (in mother)	2.1	2.4	6.9	-2.6	-1.7	0.8	1.1	0.8
Nervous feelings	2.1	3.8	6.0	1.8	1.4	-2.5	-2.1	-2.0
Illnesses of father: Heart disease	2.1	2.9	6.1	-1.9	-0.7	-1.7	-1.4	-2.5
Friendships satisfaction	2.1	2.6	7.4	-2.7	-1.4	1.6	0.3	-0.9
Medication for cholesterol	2.1	3.2	4.5	-1.9	-2.0	1.7	2.1	-0.8
Hearing aid user	2.1	2.4	4.5	1.6	2.1	0.1	-0.6	2.0
Fractured/broken bones in last 5 years	2.1	2.7	4.5	-0.6	-1.9	2.1	2.1	0.8
Mean Putamen Volume	2.0	2.3	6.1	-1.0	-2.5	1.2	1.7	-0.2
Mouth/teeth dental problems: Dentures	2.0	3.4	9.9	0.3	-0.5	-2.1	-1.4	-3.1
Medication: Seretide 50 evohaler	2.0	2.3	3.9	-1.8	-1.7	1.2	2.0	0.2
Trunk fat mass	1.9	8.2	23.5	-0.1	1.5	2.8	2.6	4.8
Loud music exposure frequency	1.9	2.1	4.8	0.4	-0.1	-2.2	-1.3	-1.9
Body fat percentage	1.9	7.6	21.8	0.0	1.5	2.8	2.5	4.7
Tinnitus: Yes, but not now, but have in the past	1.8	1.9	4.8	1.5	2.2	-0.9	-1.2	0.2
Hearing difficulty/problems with background noise	1.8	2.9	4.9	2.2	1.9	-1.8	-1.7	0.1
Eye problems/disorders: None of the above	1.8	2.1	4.0	-1.0	-2.0	-1.3	-1.3	-1.4
Migraine (self-reported)	1.8	2.2	4.9	-2.2	-1.1	1.8	1.3	0.3
Medication: Ibuprofen	1.8	2.2	3.9	-0.5	-0.1	2.0	1.8	1.8
Alcohol usually taken with meals	1.7	2.8	5.6	1.8	2.1	0.8	0.2	2.4
Time employed in main current job	1.7	2.0	3.2	1.4	1.5	0.7	1.8	1.4
Qualifications: A levels/AS levels or equivalent	1.7	3.7	6.1	-1.7	0.3	2.5	2.0	2.4
Illnesses of father: None of the above (group 1)	1.7	2.0	4.7	-0.1	-0.6	2.2	2.0	1.1
Average weekly fortified wine intake	1.6	1.9	4.0	0.5	1.4	-1.7	-2.0	-0.8
Mouth/teeth dental problems	1.6	2.5	4.5	-1.0	0.3	2.1	1.6	2.1
Peak expiratory flow (PEF)	1.6	3.7	6.8	0.9	1.8	2.2	1.6	2.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.9	5.0	-2.2	-0.9	1.9	0.2	0.1
Coronary Artery Disease (CAD)	1.5	1.7	4.7	-0.4	-0.3	1.5	1.2	2.2
Diabetes (mother)	1.5	2.0	3.5	1.2	1.6	-1.9	-1.2	-0.8
Birth weight of first child	1.5	2.7	6.2	-0.1	0.5	1.8	1.9	2.5
Medication: Gliclazide	1.5	1.7	3.7	1.4	1.4	-0.9	-1.9	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.2	8.1	1.2	2.9	-1.2	-2.2	0.2
Unable to work because of sickness or disability	1.5	1.9	4.2	0.1	-1.9	0.9	2.0	-1.0
Cholesterol lowering medication	1.5	2.2	3.4	1.9	1.3	-1.8	-1.6	0.3
Heart attack	1.4	1.8	4.5	-0.6	-1.2	1.3	2.1	1.1
Arm predicted mass (right)	1.4	7.1	15.4	1.2	1.5	-3.9	-3.9	-1.2
Number of full sisters	1.4	1.7	2.9	1.6	0.5	-1.7	-1.7	-0.5
Diabetes diagnosed by doctor	1.4	2.3	6.3	1.2	2.5	0.0	-0.3	2.0
Breast cancer (self-reported)	1.4	1.7	3.4	-0.3	-1.8	-1.0	-0.7	-1.9
Heart attack/myocardial infarction (self-reported)	1.4	1.8	4.2	-0.6	-1.1	1.3	2.0	1.3
Hair/balding pattern: Pattern 3	1.3	2.0	3.1	-1.7	-1.8	1.0	1.2	-1.1
Lung cancer (father)	1.3	1.6	3.1	1.8	1.3	-1.7	-0.5	0.1
Arm fat-free mass (right)	1.3	6.7	14.5	1.0	1.4	-3.8	-3.8	-1.2
Age at last live birth	1.3	1.8	3.1	-1.5	-0.7	1.8	1.5	0.9
Illnesses of father: High blood pressure	1.3	1.6	4.3	1.3	0.3	-1.4	-2.1	0.2
Supplements: Calcium	1.3	1.4	3.1	0.5	-1.8	0.2	0.7	-1.8
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.8	10.8	1.0	3.3	-0.2	-1.8	2.0
Wheeze or whistling in the chest in last year	1.2	2.2	7.2	1.5	-0.1	0.5	2.7	1.0
Whole body fat mass	1.2	5.0	16.2	0.1	1.5	1.9	1.7	4.0
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	3.3	-0.9	-1.6	-0.8	-0.3	-1.8
Arm predicted mass (left)	1.2	6.2	14.5	1.0	1.3	-3.6	-3.8	-1.1
Alzheimer’s Disease (in father)	1.1	1.2	2.2	0.9	0.9	-1.4	-1.5	-0.3
Multivitamins +/- minerals	1.1	1.4	2.8	-0.0	0.1	1.5	1.4	1.7
Had menopause	1.1	1.4	3.8	0.6	-0.2	-2.0	-0.9	-1.4
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	2.4	-0.7	-1.3	1.3	1.5	0.4
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	3.6	-1.9	-1.6	0.9	1.6	-0.0
Medication: Lansoprazole	1.1	1.2	3.0	1.5	0.4	0.7	0.7	1.7
Arm fat mass (right)	1.1	4.4	15.5	-0.3	1.3	1.7	1.2	3.9
Forced vital capacity (FVC), Best measure	1.1	4.1	10.0	0.8	3.2	-0.3	-2.4	2.1
Family relationship satisfaction	1.1	1.4	2.0	-1.4	-1.4	0.8	1.2	-1.1
Mood swings	1.1	1.9	4.1	0.4	1.0	-2.0	-1.1	-1.8
Arm fat-free mass (left)	1.1	5.3	12.2	0.8	1.2	-3.4	-3.5	-0.9
Depression (Nagel 2018)	1.0	1.5	6.0	-0.6	-0.5	-0.7	0.6	-2.5
Body Mass Index (BMI) (2010)	1.0	1.3	2.2	1.1	-1.1	1.3	1.5	0.5
Hand grip strength (right)	1.0	2.7	5.5	2.3	1.2	-1.7	-1.8	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	5.2	-0.8	-0.2	-0.8	0.2	-2.3
Had other major operations	1.0	1.3	2.7	-1.1	-1.6	-0.3	0.0	-1.5
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	3.3	-0.8	-1.8	1.1	1.0	0.4
Number of full brothers	1.0	1.3	2.2	-1.1	-0.4	1.3	1.0	1.5
Age at first live birth	1.0	1.8	3.5	-1.0	0.5	1.5	1.4	1.9
Knee pain experienced in last month	1.0	1.6	2.8	0.6	1.7	-1.4	-1.6	0.5
Qualifications: nursing, teaching	1.0	1.5	2.4	-0.9	-1.0	1.6	1.1	1.5
Medication: Aspirin	1.0	1.4	2.7	1.6	1.1	0.1	0.9	1.4
Guilty feelings	1.0	1.5	4.0	0.8	-1.2	1.2	2.0	-0.1
Medication: Blood pressure	1.0	1.8	3.0	1.7	0.0	-1.7	-1.7	0.5
Ever had prostate specific antigen (PSA) test	1.0	1.1	2.4	0.2	1.2	1.3	0.5	1.5
Ever depressed for a whole week	1.0	1.2	2.3	-0.6	-0.8	0.8	1.5	1.5
Fasting Glucose	0.9	1.1	2.6	0.8	-0.6	-1.3	-0.4	-1.6
LDL Cholesterol	0.9	1.4	4.1	-2.0	-1.6	0.3	-0.2	0.1
Triglycerides	0.9	1.5	3.6	0.7	-0.2	-1.9	-1.4	-1.3
Average weekly spirits intake	0.9	1.1	1.9	1.3	1.3	-1.4	-0.5	0.3
Relative age of first facial hair	0.9	1.8	2.8	1.5	1.7	-1.3	-1.6	-0.2
Severe depression (siblings)	0.9	1.0	1.9	0.3	1.4	-1.3	-0.9	-0.9
Maternal smoking around birth	0.9	1.3	3.0	0.3	-0.4	-0.9	-1.7	-1.6
Qualifications: CSEs or equivalent	0.9	1.1	4.1	-0.9	-2.0	0.6	0.4	0.5
Medication: Atenolol	0.9	1.1	3.9	2.0	1.3	-0.1	0.1	0.3
Prospective memory result	0.9	1.1	1.7	-0.2	-1.2	-1.1	-1.0	-1.3
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	1.8	1.3	0.7	-1.1	-1.4	-0.5
Number of children fathered	0.9	1.0	2.7	1.3	1.6	-0.5	-0.6	0.3
Comparative height size at age 10	0.9	4.9	9.9	-2.5	-3.1	2.4	1.8	0.1
Medication: Aspirin	0.9	1.1	2.5	1.6	1.3	-0.4	0.2	1.2
Arm fat mass (left)	0.9	3.7	13.5	0.1	1.6	1.3	0.9	3.7
Medication: Bendroflumethiazide	0.9	1.3	2.3	1.0	1.2	-1.3	-1.5	0.2
Irritability	0.9	1.5	3.0	0.2	0.7	-1.7	-1.4	-1.4
Alcohol drinker status: Previous	0.9	1.1	1.9	0.7	0.9	-1.4	-1.3	-0.7
Breast Cancer	0.8	1.8	4.1	1.5	2.0	0.2	0.6	1.6
Prostate Cancer	0.8	1.2	4.2	-0.4	-2.1	-0.5	0.1	-1.1
HDL Cholesterol	0.8	1.3	2.5	-1.0	0.6	1.6	1.4	0.9
Number of treatments/medications taken	0.8	1.4	3.1	1.7	1.6	0.1	0.0	1.3
Diabetes (father)	0.8	1.0	2.4	-1.5	-1.6	0.3	0.5	-0.2
Supplements: Glucosamine	0.8	1.0	2.7	1.0	1.1	0.6	-0.1	1.6
Medication: Levothyroxine sodium	0.8	1.4	3.7	-0.9	0.3	-1.0	-1.1	-1.9
Diabetes (self-reported)	0.8	1.2	3.3	0.6	1.3	0.8	0.4	1.8
Qualifications: College or University degree	0.8	2.5	6.3	-0.6	-0.3	2.5	1.8	1.5
Medication: Blood pressure	0.8	1.3	4.7	-0.8	2.2	1.0	0.5	0.4
Eye problems/disorders: Cataract	0.8	1.0	2.1	1.2	1.5	0.8	0.4	0.7
Mineral and other dietary supplements	0.8	1.1	1.8	-1.3	0.3	1.3	1.0	0.8
Major Depression (MDD)	0.7	0.8	2.1	0.3	1.5	-0.3	-1.4	0.2
Hypothyroidism (self reported)	0.7	1.5	3.0	-0.1	0.5	-1.6	-1.3	-1.7
Type 2 Diabetes (T2D) (2018)	0.7	1.4	4.0	1.2	2.0	-0.7	-0.9	0.4
Supplements: Zinc	0.7	0.7	1.5	-0.2	-0.8	1.2	1.2	0.4
Waist circumference	0.7	2.5	4.3	1.7	2.1	-1.5	-1.0	1.4
Trunk fat-free mass	0.7	3.9	9.2	0.3	0.6	-2.8	-3.0	-1.4
Falls in the last year	0.7	1.0	2.1	1.5	0.5	0.4	1.3	0.8
Trunk predicted mass	0.7	4.0	9.7	0.4	0.5	-2.8	-3.1	-1.5
Tense / ‘highly strung’	0.7	1.2	2.5	0.8	1.2	-1.6	-1.0	-0.8
Leg fat percentage (right)	0.7	2.5	5.3	1.2	2.3	-0.1	-0.4	2.3
Pulse rate, automated reading	0.7	2.2	5.5	0.4	0.8	-1.8	-2.3	-1.1
Suffer from ‘nerves’	0.7	1.2	3.5	1.9	0.2	-1.3	-0.5	-0.6
Long-standing illness, disability or infirmity	0.7	1.1	2.5	-0.3	-0.5	1.6	1.3	1.1
Commuting to job workplace: Walk	0.7	0.8	1.8	0.4	0.1	0.8	1.3	1.1
Asthma (self-reported)	0.7	1.4	1.7	-1.1	-1.2	1.3	1.3	1.0
Wears glasses or contact lenses	0.7	0.8	3.1	-1.8	-0.4	0.4	-0.4	-0.7
High cholesterol (Self-reported)	0.7	1.2	3.2	1.1	1.8	-1.0	-0.8	0.0
Average weekly beer plus cider intake	0.7	1.0	1.8	0.8	-0.3	-1.2	-0.8	-1.4
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.1	1.4	1.3	-0.7	-0.3	0.1
Pain experienced in last month	0.7	1.2	2.6	0.9	-0.3	-1.2	-1.6	-1.1
Worry (Nagel 2018)	0.6	1.2	3.5	1.9	-0.0	-0.6	0.3	-1.5
Primary Biliary Cirrhosis	0.6	0.8	1.2	-1.1	-0.8	-1.0	-0.1	-1.1
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.7	0.3	-1.0	-0.6	-0.2	-1.3
Hand grip strength (left)	0.6	1.5	4.2	2.0	0.1	-1.1	-1.1	-1.0
Sensitivity / hurt feelings	0.6	1.1	4.3	0.5	0.9	-2.1	-0.4	-0.1
Medication: Co-codamol	0.6	0.7	1.8	1.4	0.4	-0.7	-1.0	0.0
Medication: Metformin	0.6	0.9	1.6	1.3	1.1	-0.6	-0.9	0.7
Pack years adult smoking proportion	0.6	0.9	3.4	0.4	-1.8	0.4	1.0	0.2
Relative age voice broke	0.6	0.9	2.1	0.5	1.4	-0.9	-1.1	-0.6
Sitting height	0.6	4.4	5.6	-2.4	-1.3	2.4	2.1	2.2
Alcohol intake versus 10 years previously	0.6	0.9	2.4	0.4	-0.7	-1.1	-0.3	-1.6
Worrier / anxious feelings	0.6	1.2	3.0	-0.4	-1.2	0.6	1.0	-1.7
Forced expiratory volume in 1-second (FEV1)	0.6	2.2	6.2	0.7	2.5	0.0	-1.6	1.3
Asthma	0.6	1.1	1.5	-0.8	-1.2	1.2	1.2	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	1.8	0.2	1.1	0.3	0.6	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.8	3.0	0.2	-0.8	-0.7	-0.2	-1.7
Headache pain in last month	0.6	1.1	2.2	-1.5	-1.2	0.7	1.0	-0.4
Medication for cholesterol, blood pressure or diabetes	0.6	1.1	4.6	0.4	-2.1	-0.5	-0.3	-0.5
High blood pressure (siblings)	0.6	0.9	1.4	1.2	0.8	0.9	0.8	1.0
Emphysema/chronic bronchitis	0.6	0.7	2.8	-0.3	-1.7	-0.3	-0.3	-0.5
Heart disease (mother)	0.6	0.7	1.6	1.3	1.0	0.8	0.4	0.4
Leg fat mass (right)	0.6	2.2	5.9	0.7	2.2	0.0	-0.2	2.4
Handedness (chirality/laterality): Left-handed	0.6	0.7	2.0	-0.3	0.1	-1.4	-0.6	-1.0
Osteoarthritis (self-reported)	0.6	0.7	1.2	-0.6	1.0	-0.3	-0.9	1.1
Leg fat percentage (left)	0.6	2.3	5.0	1.2	2.1	-0.3	-0.5	2.2
Neuroticism (2016)	0.5	0.7	2.3	0.4	-0.2	0.9	1.5	0.5
Ulcerative Colitis	0.5	0.7	1.7	-0.4	-0.1	1.3	1.2	0.3
BMI	0.5	2.8	4.8	1.8	2.2	-0.6	-1.2	2.0
Height	0.5	9.6	17.5	-2.3	-1.1	4.2	3.6	3.3
Cardiovascular Disease	0.5	1.7	2.5	1.0	1.6	-1.6	-1.6	-0.2
Lung FEV1/FVC ratio	0.5	2.5	5.1	1.5	1.5	-2.3	-0.9	-1.4
Angina	0.5	0.7	2.2	0.7	-0.1	-1.5	0.5	-0.7
Vitamin and mineral supplements	0.5	0.6	1.6	-0.9	0.3	-0.2	-0.9	-1.3
Townsend deprivation index at recruitment	0.5	0.7	1.7	1.3	0.6	-1.0	-0.8	0.1
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.2	-1.1	-0.5	1.1	0.6	-0.2
Chronic bronchitis/emphysema (father)	0.5	0.5	1.5	0.0	-1.0	0.1	1.2	-0.4
High blood pressure (mother)	0.5	0.7	2.1	-0.7	0.2	0.9	-0.3	1.4
Body mass index (BMI)	0.5	2.1	4.0	1.1	2.0	-0.6	-1.0	2.0
Forced vital capacity (FVC)	0.5	1.9	4.6	0.2	2.1	-0.1	-1.9	1.3
Father’s age at death	0.5	0.6	2.1	-1.5	-0.9	0.4	0.1	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	1.3	0.7	-0.8	0.3	0.4	1.1
Medication: Cholesterol lowering	0.5	0.8	3.1	0.6	1.8	-0.2	-0.1	0.8
Medication: Amlodipine	0.5	0.6	1.7	-0.1	1.3	-0.4	-0.5	1.0
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.2	-0.8	-0.1	-0.6	-1.0	1.1
Exposure to tobacco smoke outside home	0.5	0.7	1.8	1.3	0.7	-1.0	-0.2	0.1
Shortness of breath walking on level ground	0.5	0.6	1.6	1.3	0.7	0.5	0.5	0.6
Had major operations	0.5	0.6	1.5	-1.2	-0.8	0.2	-0.7	-0.4
Commuting to job workplace: Car/motor vehicle	0.5	0.5	1.3	1.2	-0.2	0.0	0.0	1.1
Average weekly red wine intake	0.5	0.7	1.6	-0.6	1.1	0.3	-0.6	1.3
Average weekly champagne plus white wine intake	0.5	0.7	1.5	-1.1	0.7	0.7	-0.1	1.2
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.8	1.3	0.6	-0.5	-0.5	0.5
Ever smoked	0.5	0.9	1.5	-1.0	0.6	-1.2	-1.1	-0.7
Leg fat mass (left)	0.5	1.9	5.2	0.7	2.0	-0.2	-0.3	2.3
Bipolar Disorder (2018)	0.4	0.7	0.9	-0.9	-1.0	0.8	0.9	-0.6
Depressed Affect (Nagel 2018)	0.4	0.9	2.2	0.5	0.0	-1.5	-0.8	-1.3
Alzheimer’s Disease (including proxy)	0.4	0.6	1.1	-1.0	-0.8	-0.9	0.1	-0.5
Crohns Disease (2012)	0.4	0.7	2.3	-0.3	-0.1	-0.6	-0.8	-1.5
Smoking Status	0.4	1.1	2.4	-1.1	-0.0	-1.5	-1.1	-0.8
Medication for hormone replacement therapy	0.4	0.4	1.1	-0.1	1.0	0.7	0.6	-0.0
Serious illness, injury or assault to yourself	0.4	0.5	1.7	-0.6	-0.1	0.7	1.3	0.2
Past tobacco smoking	0.4	0.6	1.4	0.2	-1.2	1.1	0.8	-0.2
Qualifications: None of the above	0.4	0.8	1.6	1.1	1.3	-1.1	-0.1	-0.2
Illnesses of siblings	0.4	0.5	1.2	-0.9	-0.4	-0.5	-0.2	-1.1
Neuroticism score	0.4	0.8	1.9	0.9	0.1	-1.2	-0.3	-1.4
Hip circumference	0.4	1.8	6.0	0.0	0.9	1.2	0.8	2.4
Pulse rate	0.4	0.6	1.5	-0.5	0.7	-1.2	-0.9	-0.3
Illnesses of mother	0.4	0.5	1.3	0.2	-0.8	-0.4	0.5	-1.1
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.3	0.8	-0.0	0.6	0.5	1.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	2.0	-0.4	-0.6	0.6	-0.1	1.4
Gout (self-reported)	0.4	0.6	1.2	0.1	0.9	1.1	0.8	0.7
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	2.6	-0.2	0.1	-0.6	-0.6	-1.6
Worry too long after embarrassment	0.4	0.6	1.4	-0.6	-1.2	0.6	1.1	0.1
Angina (self-reported)	0.4	0.5	1.2	0.6	-0.2	-1.1	0.8	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.5	-0.1	0.3	0.6	0.8	-1.2
Chest pain or discomfort	0.4	0.6	0.9	0.6	0.8	-0.9	-0.3	-0.9
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	2.0	0.2	1.4	0.4	-0.4	-0.3
Supplements: Vitamin C	0.4	0.4	1.6	0.1	-1.3	-0.6	-0.5	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.0	-0.5	0.1	0.5	0.9	1.0
Smoking status: Previous	0.4	0.6	1.0	-0.2	1.0	-0.9	-0.9	0.7
Smoking status: Current	0.4	0.6	1.4	-0.5	-0.1	-1.2	-0.4	-1.2
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.9	0.6	0.9	-0.9	-0.6	-0.2
Medication: Lisinopril	0.4	0.5	0.9	0.4	-0.7	0.2	-1.0	0.9
Number of operations (self-reported)	0.4	0.7	1.7	0.0	0.1	-0.8	-1.3	-1.0
Age started oral contraceptive pill	0.4	0.6	1.4	0.5	-0.6	-0.9	-0.1	-1.2
Pack years of smoking	0.4	0.6	1.9	0.8	-1.4	0.2	0.6	0.1
Intelligence (Savage-Jansen 2018)	0.3	0.8	2.1	0.2	0.1	1.4	0.9	1.1
Neuroticism (Nagel 2018)	0.3	0.7	1.4	1.1	-0.0	-1.2	-0.0	-1.0
Allergy or Eczema	0.3	0.7	2.1	-0.5	-0.3	-0.7	-1.4	0.8
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.9	-0.4	0.6	-0.2	0.7	-1.0
Current tobacco smoking	0.3	0.5	1.0	-0.6	-0.3	-1.0	-0.3	-1.0
Fed-up feelings	0.3	0.6	1.2	0.7	0.4	-1.1	-0.8	-0.5
Age when periods started (menarche)	0.3	0.7	2.5	0.9	1.6	-0.1	0.5	0.4
Number of incorrect matches in round	0.3	0.5	2.3	0.3	1.5	-0.4	-0.2	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	2.3	-0.0	0.2	0.3	0.4	-1.5
Weight	0.3	1.4	5.9	0.2	1.0	0.4	0.1	2.4
Standing height	0.3	3.5	5.3	-1.8	-1.8	2.1	2.3	1.1
Length of working week for main job	0.3	0.3	0.7	0.7	-0.1	-0.5	-0.8	0.1
Breastfed as a baby	0.3	0.3	0.5	-0.4	0.7	0.7	0.6	0.4
Hair/balding pattern: Pattern 4	0.3	0.8	1.6	-0.7	0.0	-1.3	-0.4	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.7	0.5	0.4	-0.6	-0.8	-0.3
Medication for pain relief, constipation, heartburn	0.3	0.6	1.5	-0.4	-0.9	-0.3	-0.4	-1.2
Neck or shoulder pain in last month	0.3	0.4	0.9	0.5	0.9	-0.7	-0.5	-0.2
Medication: Omeprazole	0.3	0.3	1.1	0.7	1.0	-0.1	0.1	0.3
Alcohol intake frequency.	0.3	0.7	1.2	0.8	0.1	-1.0	-0.9	-1.1
Overall health rating	0.3	0.6	1.6	1.3	0.5	0.2	0.9	0.4
Leg pain on walking	0.3	0.3	0.6	0.7	0.2	-0.8	-0.6	0.2
Illnesses of siblings: Diabetes	0.3	0.4	1.5	0.2	1.2	-0.4	-0.5	0.1
Whole body fat-free mass	0.3	1.8	4.5	0.1	0.7	-1.9	-2.1	-0.3
Whole body water mass	0.3	1.9	4.7	0.1	0.7	-2.0	-2.2	-0.4
Ever taken oral contraceptive pill	0.3	0.3	0.8	0.3	0.8	0.5	0.2	0.9
Financial situation satisfaction	0.3	0.4	0.9	0.6	0.7	-0.1	-0.9	0.5
Commuting to job workplace: Public transport	0.3	0.3	1.0	-1.0	0.1	-0.1	-0.0	-0.8
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.6	0.8	-0.5	-0.8	-0.7	0.1
Alcohol drinker status: Never	0.3	0.4	1.1	-0.5	0.2	0.4	-1.0	0.8
Risk taking	0.3	0.5	0.7	0.8	0.9	0.2	0.8	0.7
Bipolar Disorder or Schizophrenia	0.2	0.6	1.1	-0.7	-1.0	0.6	0.3	-0.9
Schizophrenia vs Biploar Disorder	0.2	0.3	0.7	0.9	-0.2	-0.2	0.5	0.5
Ulcerative Colitis (UC)	0.2	0.3	0.9	-0.9	0.3	0.8	0.3	0.1
Verbal and Numeric Reasoning (VNR)	0.2	0.6	1.2	0.6	-0.1	1.1	0.6	0.9
Ovarian Cancer	0.2	0.3	0.6	0.5	0.8	0.1	0.4	0.7
HbA1C	0.2	0.3	1.0	-0.0	0.3	-0.5	-0.1	-1.0
Rheumatoid Arthritis	0.2	0.3	0.7	0.4	-0.5	-0.9	-0.6	-0.3
Blood Eosinophil Count	0.2	1.5	2.8	1.7	0.6	-1.6	-1.4	-0.5
Neuroticism	0.2	0.6	1.3	0.9	-0.6	-0.5	0.5	-1.1
Chronotype (morning person)	0.2	0.5	1.3	0.2	1.1	0.4	0.8	0.4
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.5	-0.2	-0.3	0.2	-0.4	1.2
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.4	-0.7	-0.5	-0.5	0.5	-0.4
Hair/balding pattern: Pattern 2	0.2	0.2	0.7	-0.2	-0.2	0.8	0.5	0.2
Allergy	0.2	0.5	1.3	0.4	1.0	-0.3	-0.3	-1.1
Fluid intelligence score	0.2	0.5	0.9	1.0	-0.8	0.4	0.6	0.7
Depression (self-reported)	0.2	0.3	1.1	1.0	-0.1	-0.2	0.3	-0.3
Exposure to tobacco smoke at home	0.2	0.2	1.1	-0.1	-0.1	0.2	1.1	0.0
Medication: Ventolin 100micrograms inhaler	0.2	0.3	1.0	-0.3	-0.2	0.4	1.0	0.2
Comparative body size at age 10	0.2	0.6	2.1	0.0	-1.5	0.5	0.8	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.6	-0.8	-0.5	-0.4	-0.3	-0.6
Medication: Allopurinol	0.2	0.3	0.7	-0.1	0.5	0.7	0.2	0.8
Loneliness, isolation	0.2	0.2	0.8	-0.2	0.5	-0.9	-0.1	-0.1
Ever had bowel cancer screening	0.2	0.2	0.9	0.2	-0.3	1.0	0.1	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.7	0.7	-0.6	0.1	0.2	0.8
Back pain experienced in last month	0.2	0.4	0.6	-0.2	0.4	0.7	0.8	0.6
Number of self-reported non-cancer illnesses	0.2	0.4	0.6	-0.6	-0.3	-0.6	-0.7	0.8
Medication: Paracetamol	0.2	0.2	0.5	0.2	-0.3	0.6	0.7	-0.3
Basal metabolic rate	0.2	1.1	2.7	0.1	0.9	-1.4	-1.6	0.5
Myopia	0.2	0.3	0.4	-0.6	0.1	0.4	0.6	0.6
Basal cell carcinoma (self-reported)	0.2	0.3	0.5	-0.4	-0.3	0.2	0.6	-0.7
Schizophrenia (2018)	0.1	0.1	0.4	-0.2	-0.4	0.2	-0.2	-0.6
Crohns Disease (2017)	0.1	0.3	0.7	0.1	0.4	0.8	0.8	0.3
Irritable Bowel Disease (IBD)	0.1	0.3	0.6	-0.5	0.5	0.8	0.6	0.0
Lupus	0.1	0.2	0.4	0.4	0.1	-0.5	0.2	0.6
Schizophrenia (2014)	0.1	0.2	0.4	-0.1	0.4	0.7	0.2	0.4
Blood Platelet Count	0.1	1.4	4.6	0.1	-2.1	-0.2	0.7	-1.3
Blood Red Count	0.1	1.0	2.1	0.4	1.4	-0.2	-0.8	1.4
Blood White Count	0.1	0.9	2.0	1.1	-0.1	-1.0	-0.4	-1.4
Heel T-Score	0.1	0.5	1.5	1.2	0.2	-0.2	1.0	0.2
Respiratory disease	0.1	0.2	0.9	-0.1	-0.2	-0.1	-0.3	0.9
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.1	0.3	-0.2	-0.1	-0.4	0.3
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.3	0.6	0.2	-0.2	-0.5	-0.0
Ever had hysterectomy (womb removed)	0.1	0.1	0.1	-0.2	0.4	-0.1	-0.1	-0.3
Impedance of leg (right)	0.1	0.5	1.3	0.3	-0.2	0.9	1.2	0.3
Leg fat-free mass (left)	0.1	0.6	2.4	-0.4	0.6	0.2	-0.0	1.5
Taking other prescription medications	0.1	0.2	0.5	-0.1	-0.6	0.1	0.7	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.7	0.3	-0.2	-0.1	0.8	0.3
High blood pressure	0.1	0.3	1.0	0.1	0.6	-0.4	-1.0	-0.0
Stomach or abdominal pain in last month	0.1	0.1	0.3	0.1	-0.5	-0.1	0.3	-0.4
Impedance of leg (left)	0.1	0.4	1.0	0.5	0.0	0.7	1.0	0.4
Leg predicted mass (left)	0.1	0.6	2.4	-0.3	0.5	0.2	0.0	1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.9	-0.6	-0.3	0.3	0.9	0.4
Financial difficulties in last 2 years	0.1	0.2	0.3	-0.6	-0.2	-0.5	-0.4	-0.1
Number of live births	0.1	0.1	0.2	-0.1	0.2	0.3	0.5	0.1
Noisy workplace	0.1	0.1	0.2	0.2	0.2	0.3	0.5	0.3
Blood clot in the leg (DVT)	0.1	0.1	0.2	-0.2	0.2	-0.2	-0.3	-0.4
Medication: Paracetamol	0.1	0.1	0.3	0.1	0.4	0.3	0.6	-0.5
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	0.2	0.5	-0.2	-0.2	-0.2
Hypertension (Self-reported)	0.1	0.4	1.3	0.3	0.7	-0.3	-1.2	-0.1
Leg fat-free mass (right)	0.1	0.5	2.0	-0.6	0.4	0.0	-0.2	1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.3	-0.4	-0.1	-0.6	-0.3	-0.4
Leg predicted mass (right)	0.1	0.5	2.0	-0.5	0.4	-0.1	-0.3	1.4
Miserableness	0.1	0.2	0.4	0.0	0.4	-0.7	-0.4	0.5
Mother’s age at death	0.1	0.1	0.2	0.5	-0.4	0.3	0.4	0.1
Medication: Atorvastatin	0.1	0.2	0.4	0.6	0.4	-0.5	-0.1	-0.4
Commuting to job workplace: Cycle	0.1	0.1	0.2	0.5	-0.3	-0.0	0.1	-0.2
Vascular/heart problems diagnosed by doctor	0.1	0.4	1.0	-0.3	-1.0	0.1	0.4	-0.9
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.4	-0.6	-0.3	-0.2	-0.2	-0.5
Heart disease (siblings)	0.1	0.1	0.3	0.5	-0.2	0.1	0.1	0.1
Hair Pigment	0.0	1.0	2.4	0.9	1.5	-0.7	-1.1	0.3
Tanning	0.0	0.3	0.7	-0.8	-0.7	-0.2	0.5	0.2
Medication: Ramipril	0.0	0.0	0.1	-0.1	-0.4	0.3	0.0	0.0
Happiness	0.0	0.1	0.2	-0.0	0.4	0.1	0.3	-0.2
Health satisfaction	0.0	0.0	0.1	-0.3	-0.1	0.1	-0.2	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.3	0.0	-0.0	-0.5	-0.1	-0.4

Hub : Genes

ADAMTS8

Models

Trait associations