Best TWAS P=1.8e-13 · Best GWAS P=4.02e-26 conditioned to 6.52e-16
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | LIN7C | 0.14 | 0.09 | lasso | 3 | 0.06 | 1.9e-04 | 5.7 | -5.2 | 2.3e-07 | -0.21 | 0.54 | 0.02 | FALSE |
| 2 | GTEx | Colon Transverse | LIN7C | 0.13 | 0.04 | enet | 19 | 0.08 | 1.4e-04 | 5.3 | 7.4 | 1.8e-13 | 0.46 | 0.15 | 0.22 | TRUE |
| 3 | GTEx | Esophagus Mucosa | LIN7C | 0.10 | 0.05 | enet | 14 | 0.04 | 1.1e-03 | 3.9 | 5.5 | 3.1e-08 | 0.19 | 0.93 | 0.02 | FALSE |
| 4 | GTEx | Skin Not Sun Exposed Suprapubic | LIN7C | 0.11 | 0.03 | lasso | 4 | 0.02 | 3.4e-02 | 5.3 | 5.4 | 7.4e-08 | 0.28 | 0.20 | 0.08 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | LIN7C | 0.10 | 0.09 | lasso | 2 | 0.07 | 8.1e-10 | 5.7 | 5.3 | 9.6e-08 | 0.16 | 1.00 | 0.00 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LIN7C | 0.09 | 0.12 | lasso | 2 | 0.12 | 2.6e-13 | 5.7 | 5.3 | 8.7e-08 | 0.14 | 0.00 | 1.00 | FALSE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | LIN7C | 0.09 | 0.10 | enet | 7 | 0.09 | 8.1e-09 | 5.7 | 5.9 | 4.6e-09 | 0.16 | 0.00 | 1.00 | FALSE |