Hub : Traits :

Heel bone mineral density (BMD) T-score, automated (left)

1023 significantly associated models · 256 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 752566 1567206 1 1 1.6e-08 1.6e-07 1.0e+00 100 KLHL17
2 1 7715776 9571422 2 1 1.7e-11 1.3e-09 2.7e-01 97 RERE
3 1 15123100 16552772 1 1 1.0e-08 1.4e-08 2.3e-01 96 CASP9
4 1 22197336 22718991 1 1 1.4e-17 3.7e-22 1.6e-25 -16 WNT4
5 1 37730550 39167106 2 1 2.6e-09 3.0e-08 2.3e-01 95 FHL3
6 1 112312154 114196883 4 1 1.4e-14 1.4e-14 1.0e-02 89 WNT2B
7 1 118878656 120380990 1 1 2.2e-09 2.7e-10 1.1e-03 73 WARS2
8 1 219166366 220808921 1 1 1.3e-09 1.4e-10 3.5e-02 89 SLC30A10
9 1 239954252 241470634 1 1 5.5e-37 5.2e-50 2.2e-16 70 GREM2
10 2 39636469 41534961 1 1 6.9e-09 1.3e-12 4.5e-08 40 SLC8A1
11 2 41579722 42984340 1 1 1.3e-08 1.6e-19 1.5e-12 39 PKDCC
12 2 53647729 55895321 8 13 7.7e-39 7.6e-55 NaN NaN AC093110.3 ACYP2 C2orf73 EML6 RPL23AP32 SPTBN1 TSPYL6
13 2 64168232 65573478 1 1 4.9e-09 1.4e-08 9.5e-02 91 SERTAD2
14 2 181042370 182430120 1 1 2.1e-07 1.7e-06 4.0e-01 97 FTH1P20
15 2 202200575 203592180 1 1 3.1e-11 1.8e-32 4.0e-29 11 FZD7
16 3 48515079 50800146 15 2 1.0e-11 8.3e-12 3.7e-01 98 AMT RBM6
17 3 55894951 57350441 1 1 3.0e-07 2.1e-09 7.8e-04 69 CCDC66
18 3 100350244 101922655 1 1 1.7e-07 2.4e-07 9.0e-03 74 SENP7
19 3 155695485 157456920 4 2 2.7e-17 2.6e-15 2.8e-01 98 LEKR1 TIPARP
20 4 69713 2058475 13 10 1.8e-39 8.5e-31 NaN NaN CRIPAK FGFRL1 IDUA KIAA1530
21 4 57587795 58088682 1 1 1.2e-07 8.2e-09 2.2e-02 84 C4orf14
22 4 85698680 89692911 7 4 4.1e-14 8.8e-14 1.0e+00 100 HSD17B13 IBSP RP13-514E23.2 SPP1
23 4 144882744 147552337 4 2 3.0e-10 4.5e-11 1.8e-05 58 MMAA ZNF827
24 5 39132847 39670061 1 1 8.4e-08 8.3e-08 7.5e-04 60 DAB2
25 5 53906103 55410585 1 1 7.8e-08 1.2e-07 4.5e-01 98 SKIV2L2
26 5 80008704 80761967 1 1 2.7e-12 2.0e-12 1.0e+00 100 RASGRF2
27 5 123274918 124774701 1 1 3.1e-07 1.7e-06 5.0e-03 66 ZNF608
28 6 44079216 46043561 1 1 4.3e-19 8.1e-26 1.9e-12 55 SUPT3H
29 6 73710903 75236060 1 1 1.7e-09 2.6e-11 4.2e-03 82 CD109
30 6 126892049 128359362 3 2 5.8e-74 1.5e-89 2.7e-13 87 ECHDC1 RSPO3
31 6 132368241 134546685 3 4 1.6e-11 2.1e-36 2.3e-18 52 C6orf192 EYA4 VNN2
32 6 151118271 153120904 4 8 2.8e-93 4.7e-76 NaN NaN C6orf97 CCDC170 ESR1 RMND1
33 7 14953576 16424863 1 1 3.3e-09 5.4e-14 2.6e-08 45 MEOX2
34 7 26871554 28479059 2 1 8.0e-09 1.5e-14 6.1e-11 28 AC004549.6
35 7 37260712 38687833 1 6 2.4e-27 5.0e-41 1.8e-01 99 EPDR1
36 7 91380845 93160671 2 1 2.9e-09 3.6e-08 1.1e-02 78 GATAD1
37 7 119892061 121729795 5 8 1.8e-238 0.0e+00 NaN NaN C7orf58 CPED1 FAM3C
38 8 8092025 13120332 39 1 2.0e-22 5.7e-26 1.9e-06 80 ERI1
39 8 70788124 72399360 4 1 1.1e-09 4.8e-10 1.8e-08 18 XKR9
40 9 96102832 97571455 2 1 9.2e-10 6.0e-08 1.0e-01 91 BARX1
41 10 122989048 124407934 1 1 4.1e-08 6.7e-07 4.8e-02 84 RP11-500G22.2
42 11 26818083 28220506 1 1 1.8e-13 4.0e-26 6.5e-16 42 LIN7C
43 11 34460769 35949179 1 1 5.6e-09 4.3e-09 1.0e+00 100 CD44
44 11 45945837 48285906 13 1 9.3e-16 5.4e-17 2.2e-03 87 ARFGAP2
45 11 59239839 62326265 7 3 1.1e-08 2.5e-09 3.7e-01 98 FADS2 MS4A14 MS4A2
46 11 64669105 66116911 2 1 1.5e-12 2.5e-08 1.2e-01 92 SIPA1
47 11 67339278 69623641 9 2 3.7e-17 4.5e-23 5.0e-05 83 SAPS3 TPCN2
48 11 111354161 112921923 2 2 6.5e-31 3.8e-45 1.8e-13 73 BCO2 RP11-356J5.12
49 11 114340771 116072203 1 2 1.4e-12 1.4e-16 6.2e-01 100 CADM1
50 12 52990150 54388473 2 1 3.5e-08 2.5e-08 1.0e+00 100 ESPL1
51 12 123558705 125196704 4 1 1.9e-10 3.4e-08 7.0e-02 89 DNAH10
52 13 42149812 43594717 1 1 2.7e-07 6.3e-27 3.5e-21 23 AKAP11
53 13 49557805 51390447 2 4 2.4e-10 2.3e-09 1.0e+00 100 DLEU2 EBPL
54 13 98746497 100437143 2 2 3.4e-16 2.9e-18 2.5e-02 93 DOCK9
55 14 34754717 36195312 1 1 1.1e-07 1.1e-07 1.0e+00 100 SRP54
56 14 53731553 55118795 1 1 1.7e-32 1.7e-33 5.8e-07 83 BMP4
57 14 103161201 105211221 9 1 1.5e-18 1.1e-18 1.0e+00 100 MARK3
58 15 51255019 51946100 2 2 7.3e-14 6.0e-15 2.9e-04 78 CYP19A1 GLDN
59 15 90208219 91886448 3 1 5.0e-10 1.1e-09 3.2e-01 97 IQGAP1
60 16 86671 1115377 3 1 8.6e-09 3.5e-11 1.6e-04 68 TMEM8A
61 16 66062381 68125316 7 1 8.9e-11 1.8e-13 8.3e-05 71 LRRC29
62 17 1263564 2899908 2 2 9.3e-20 3.0e-25 7.0e-03 93 SMG6
63 17 7084911 8484683 2 1 1.3e-08 3.0e-07 5.5e-01 99 LSMD1
64 17 27244473 28642380 2 1 1.6e-08 5.6e-09 9.2e-02 92 GIT1
65 17 39559539 40930095 1 1 1.4e-07 1.9e-05 1.0e-03 41 DHX58
66 17 41393295 43332365 8 1 5.9e-17 2.4e-17 1.0e+00 100 HDAC5
67 18 12966058 14385836 1 1 6.8e-08 2.3e-25 4.2e-19 26 FAM210A
68 19 32670184 34392158 6 3 1.0e-45 2.7e-45 3.7e-03 96 RHPN2
69 20 10374093 10903755 1 1 2.2e-07 1.4e-13 3.5e-14 -5 JAG1
70 20 32819871 34556216 5 1 3.1e-10 1.2e-09 1.0e+00 100 MYH7B
71 20 39567774 40193393 1 1 1.7e-08 1.1e-10 1.6e-03 76 ZHX3
72 22 19003938 20330744 1 1 7.8e-10 1.6e-42 1.6e-34 20 SEPT5
73 22 28792887 30261219 3 1 4.8e-23 3.8e-23 1.0e+00 100 KREMEN1
74 22 40789606 42301748 2 1 4.7e-10 2.6e-10 1.0e+00 100 L3MBTL2

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder (2018) 1.01 1 0 0.0 0.00 1.0e+00 MYH7B
Bipolar Disorder or Schizophrenia 1.00 1 0 0.0 0.00 1.0e+00 MYH7B
Depressed Affect (Nagel 2018) 0.85 2 1 2.2 0.00 1.0e+00 ARFGAP2 RERE
Depression (Nagel 2018) 1.05 1 0 0.0 0.00 1.0e+00 RERE
Intelligence (Savage-Jansen 2018) 0.88 4 1 2.2 -0.86 1.4e-01 AMT DLEU2 MARK3 RBM6
Neuroticism (Nagel 2018) 0.83 2 0 0.0 0.00 1.0e+00 ARFGAP2 RERE
Schizophrenia (2018) 1.04 1 0 0.0 0.00 1.0e+00 RERE
Worry (Nagel 2018) 0.99 1 0 0.0 0.00 1.0e+00 SMG6
Alzheimer’s Disease (including proxy) 1.22 1 1 2.2 0.00 1.0e+00 MS4A2
Crohns Disease (2017) 1.28 4 1 2.2 0.31 6.9e-01 AMT MARK3 RSPO3 ZHX3
Irritable Bowel Disease (IBD) 1.10 4 1 2.2 0.01 9.9e-01 AMT MARK3 WNT2B ZHX3
Ulcerative Colitis (UC) 0.89 1 0 0.0 0.00 1.0e+00 ZHX3
Reaction Time 0.98 2 0 0.0 0.00 1.0e+00 ARFGAP2 DNAH10
Verbal and Numeric Reasoning (VNR) 0.90 1 1 2.2 0.00 1.0e+00 RBM6
Breast Cancer 1.71 1 1 2.2 0.00 1.0e+00 C6orf97
Age at First Birth 1.05 1 1 2.2 0.00 1.0e+00 RBM6
Coronary Artery Disease (CAD) 1.19 1 0 0.0 0.00 1.0e+00 DNAH10
Crohns Disease (2012) 1.17 1 1 2.2 0.00 1.0e+00 AMT
HDL Cholesterol 1.47 5 2 4.4 -0.23 7.2e-01 ARFGAP2 DNAH10 FADS2 RSPO3 SIPA1
LDL Cholesterol 1.22 1 1 2.2 0.00 1.0e+00 FADS2
Lupus 1.08 2 1 2.2 0.00 1.0e+00 CD44 ERI1
Neuroticism (2016) 1.41 1 1 2.2 0.00 1.0e+00 ERI1
Rheumatoid Arthritis 1.31 1 0 0.0 0.00 1.0e+00 FADS2
Schizophrenia (2014) 1.24 2 1 2.2 0.00 1.0e+00 RERE SMG6
Triglycerides 1.50 4 1 2.2 0.11 8.9e-01 DNAH10 FADS2 HSD17B13 RSPO3
Blood Eosinophil Count 0.95 18 7 15.6 0.00 9.9e-01 AKAP11 AMT C4orf14 C6orf97 DLEU2 EBPL EML6 FADS2 GATAD1 L3MBTL2 LRRC29 MARK3 MS4A14 RERE RMND1 SAPS3 SENP7 SIPA1
Blood Platelet Count 1.34 20 14 31.1 0.21 3.7e-01 ARFGAP2 C4orf14 CCDC66 DOCK9 FADS2 GATAD1 GLDN HDAC5 HSD17B13 MARK3 MS4A14 RP13-514E23.2 RSPO3 SENP7 SEPT5 SERTAD2 SMG6 TIPARP WNT2B ZHX3
Blood Red Count 1.02 21 12 26.7 -0.09 7.0e-01 AMT CCDC66 DNAH10 DOCK9 EML6 ESPL1 FADS2 FTH1P20 FZD7 GATAD1 GIT1 HDAC5 LSMD1 MARK3 RPL23AP32 RSPO3 SAPS3 SERTAD2 SMG6 SPTBN1 TIPARP
Blood White Count 1.20 18 12 26.7 -0.23 3.3e-01 C4orf14 CYP19A1 DNAH10 EYA4 FADS2 FTH1P20 GIT1 IQGAP1 LSMD1 MS4A2 RBM6 RERE RP13-514E23.2 SMG6 SPTBN1 TIPARP TPCN2 ZHX3
Heel T-Score 48.39 101 101 224.4 0.99 1.6e-119 AC004549.6 AC093110.3 ACYP2 AKAP11 AMT ARFGAP2 BARX1 BCO2 BMP4 C2orf73 C4orf14 C6orf192 C6orf97 C7orf58 CADM1 CASP9 CCDC170 CCDC66 CD109 CD44 CPED1 CRIPAK CYP19A1 DAB2 DHX58 DLEU2 DNAH10 DOCK9 EBPL ECHDC1 EML6 EPDR1 ESPL1 ESR1 EYA4 FADS2 FAM210A FAM3C FGFRL1 FHL3 FTH1P20 FZD7 GATAD1 GIT1 GLDN GREM2 HDAC5 HSD17B13 IBSP IDUA IQGAP1 JAG1 KIAA1530 KLHL17 KREMEN1 L3MBTL2 LEKR1 LIN7C LRRC29 LSMD1 MARK3 MEOX2 MMAA MS4A14 MS4A2 MYH7B PKDCC RASGRF2 RBM6 RERE RHPN2 RMND1 RP11-356J5.12 RP11-500G22.2 RP13-514E23.2 RPL23AP32 RSPO3 SAPS3 SENP7 SEPT5 SERTAD2 SIPA1 SKIV2L2 SLC30A10 SLC8A1 SMG6 SPP1 SPTBN1 SRP54 SUPT3H TIPARP TMEM8A TPCN2 TSPYL6 VNN2 WARS2 WNT2B WNT4 XKR9 ZHX3 ZNF827
BMI 1.03 10 7 15.6 0.29 4.2e-01 AMT CADM1 DNAH10 GIT1 MARK3 RBM6 SAPS3 SMG6 WARS2 ZNF608
Height 2.02 45 34 75.6 -0.07 5.9e-01 ARFGAP2 C2orf73 C4orf14 C7orf58 CADM1 CCDC66 CPED1 CRIPAK CYP19A1 DAB2 DLEU2 DNAH10 DOCK9 EBPL EML6 EPDR1 EYA4 FADS2 FGFRL1 FHL3 GATAD1 GIT1 HSD17B13 IBSP IQGAP1 KIAA1530 KREMEN1 LRRC29 MARK3 MYH7B RMND1 RP11-500G22.2 RP13-514E23.2 RPL23AP32 SAPS3 SIPA1 SLC8A1 SPP1 SPTBN1 SUPT3H TPCN2 WARS2 WNT2B WNT4 ZNF827
Waist Hip Ratio (WHR) 3.71 19 13 28.9 0.15 5.3e-01 AMT C7orf58 CPED1 CRIPAK CYP19A1 DLEU2 DNAH10 FAM3C FGFRL1 IDUA MYH7B RSPO3 SIPA1 SLC30A10 TIPARP TMEM8A WARS2 WNT4 XKR9
Systolic Blood Pressure 1.70 14 10 22.2 0.17 5.7e-01 ARFGAP2 BMP4 CASP9 ESR1 FHL3 FTH1P20 GATAD1 LSMD1 RERE RP13-514E23.2 SIPA1 SMG6 WNT2B ZNF827
Smoking Status 1.02 4 2 4.4 0.10 9.0e-01 C4orf14 MARK3 RERE SMG6
Allergy or Eczema 1.23 3 2 4.4 0.00 1.0e+00 IQGAP1 L3MBTL2 RERE
Cardiovascular Disease 1.29 9 3 6.7 0.05 9.0e-01 AC093110.3 FTH1P20 GATAD1 GIT1 KREMEN1 LSMD1 MARK3 RP13-514E23.2 SIPA1
Hypothyroidism (self reported) 1.16 4 2 4.4 -1.00 4.7e-03 AKAP11 FADS2 FHL3 GIT1
Respiratory disease 1.28 3 2 4.4 0.00 1.0e+00 C4orf14 FADS2 RERE
Type 2 Diabetes (T2D) (2018) 1.05 1 0 0.0 0.00 1.0e+00 MARK3
Lung FEV1/FVC ratio 1.42 7 5 11.1 -0.39 3.4e-01 BMP4 FAM3C GIT1 L3MBTL2 RERE SERTAD2 SMG6
Lung FVC 1.19 11 6 13.3 -0.09 7.7e-01 BMP4 C4orf14 CD109 CYP19A1 EBPL GIT1 MYH7B SAPS3 WNT2B WNT4 ZNF827
Neuroticism 0.80 2 0 0.0 0.00 1.0e+00 ARFGAP2 RERE
Chronotype (morning person) 1.23 2 2 4.4 0.58 3.1e-01 CRIPAK RP11-500G22.2
Hair Pigment 0.61 11 8 17.8 0.32 3.4e-01 ARFGAP2 C4orf14 CD44 FADS2 LIN7C MARK3 MYH7B SAPS3 SIPA1 SPTBN1 TPCN2
Tanning 0.46 3 3 6.7 0.00 1.0e+00 LEKR1 MYH7B TPCN2
Hand grip strength (left) 1.53 4 1 2.2 0.33 3.9e-01 C7orf58 CRIPAK DNAH10 SAPS3
Number of treatments/medications taken 1.05 2 0 0.0 0.00 1.0e+00 FADS2 RBM6
Sensitivity / hurt feelings 0.92 1 1 2.2 0.00 1.0e+00 ERI1
Frequency of depressed mood in last 2 weeks 1.14 1 0 0.0 0.00 1.0e+00 ERI1
Relative age of first facial hair 1.18 2 0 0.0 0.00 1.0e+00 CYP19A1 SIPA1
Systolic blood pressure, automated reading 1.83 10 7 15.6 0.43 2.2e-01 ERI1 ESR1 FHL3 GATAD1 RERE RP13-514E23.2 SIPA1 SMG6 WNT2B ZNF827
Diabetes (mother) 1.32 1 0 0.0 0.00 1.0e+00 ZHX3
Impedance of leg (right) 1.57 16 9 20.0 -0.49 5.3e-02 CADM1 CRIPAK DHX58 ERI1 IBSP KIAA1530 L3MBTL2 MARK3 RBM6 RPL23AP32 SAPS3 SMG6 WARS2 WNT2B WNT4 ZHX3
Leg fat-free mass (left) 1.87 19 12 26.7 0.19 3.5e-01 ARFGAP2 CRIPAK DAB2 DLEU2 DOCK9 EBPL ERI1 FHL3 GATAD1 IBSP KIAA1530 MYH7B RBM6 RP13-514E23.2 SAPS3 SMG6 SUPT3H WNT4 ZNF608
Trunk fat percentage 1.35 13 6 13.3 -0.22 4.6e-01 AC093110.3 AMT CPED1 DNAH10 EML6 GIT1 HDAC5 RBM6 RERE SPTBN1 WNT2B ZHX3 ZNF608
Hand grip strength (right) 1.57 3 3 6.7 -0.54 1.6e-01 C7orf58 CRIPAK DNAH10
Maternal smoking around birth 1.12 1 0 0.0 0.00 1.0e+00 MARK3
Fed-up feelings 0.93 2 1 2.2 0.00 1.0e+00 ARFGAP2 ERI1
Relative age voice broke 0.84 1 0 0.0 0.00 1.0e+00 AMT
Taking other prescription medications 1.31 1 0 0.0 0.00 1.0e+00 RBM6
Age when periods started (menarche) 1.05 2 1 2.2 0.00 1.0e+00 RP11-500G22.2 TIPARP
Bilateral oophorectomy (both ovaries removed) 1.43 1 1 2.2 0.00 1.0e+00 WNT4
Serious illness, injury or assault to yourself 1.28 1 0 0.0 0.00 1.0e+00 SPTBN1
High blood pressure 1.50 9 3 6.7 -0.13 7.4e-01 ARFGAP2 C6orf97 ERI1 FTH1P20 KREMEN1 LSMD1 RP13-514E23.2 SIPA1 SMG6
Hayfever, allergic rhinitis or eczema 1.23 2 2 4.4 0.00 1.0e+00 IQGAP1 RERE
Medication: Levothyroxine sodium 1.03 3 0 0.0 0.00 1.0e+00 AKAP11 ERI1 FADS2
Sitting height 2.17 22 16 35.6 0.13 4.7e-01 ARFGAP2 CD109 CRIPAK DAB2 DLEU2 DOCK9 EBPL EPDR1 ERI1 EYA4 FHL3 GATAD1 HSD17B13 IBSP KREMEN1 LRRC29 MYH7B SAPS3 SUPT3H TIPARP TPCN2 WNT4
Body mass index (BMI) 1.13 9 5 11.1 0.46 2.1e-01 AMT CADM1 DNAH10 ERI1 GIT1 MARK3 RBM6 SMG6 ZNF608
Impedance of leg (left) 1.56 13 9 20.0 -0.45 1.2e-01 CADM1 DHX58 ERI1 IBSP L3MBTL2 MARK3 RBM6 RPL23AP32 SAPS3 SMG6 WARS2 WNT2B WNT4
Leg predicted mass (left) 1.86 19 12 26.7 0.19 3.5e-01 ARFGAP2 CRIPAK DAB2 DLEU2 DOCK9 EBPL ERI1 FHL3 GATAD1 IBSP KIAA1530 MYH7B RBM6 RP13-514E23.2 SAPS3 SMG6 SUPT3H WNT4 ZNF608
Trunk fat mass 1.35 9 5 11.1 0.10 7.9e-01 AMT DLEU2 DNAH10 HDAC5 RBM6 RERE WNT2B ZHX3 ZNF608
Waist circumference 1.29 11 3 6.7 0.50 1.2e-01 AMT CADM1 CRIPAK GIT1 MARK3 RBM6 RSPO3 SIPA1 SMG6 TIPARP ZNF608
Number of incorrect matches in round 1.06 1 0 0.0 0.00 1.0e+00 EBPL
Past tobacco smoking 1.01 2 1 2.2 0.00 1.0e+00 C4orf14 MYH7B
Nervous feelings 1.18 2 1 2.2 0.00 1.0e+00 ERI1 SMG6
Hearing difficulty/problems with background noise 1.24 1 0 0.0 0.00 1.0e+00 ARFGAP2
Hair/balding pattern: Pattern 2 1.59 1 1 2.2 0.00 1.0e+00 EYA4
Forced vital capacity (FVC) 1.83 14 5 11.1 -0.02 9.4e-01 ARFGAP2 BARX1 C4orf14 CRIPAK CYP19A1 DLEU2 EBPL FGFRL1 FHL3 GIT1 SAPS3 SIPA1 TPCN2 WNT4
Heel bone mineral density (BMD) T-score, automated (right) 33.50 102 88 195.6 1.00 8.4e-158 AC004549.6 AC093110.3 ACYP2 AKAP11 AMT ARFGAP2 BARX1 BCO2 BMP4 C2orf73 C4orf14 C6orf192 C6orf97 C7orf58 CADM1 CASP9 CCDC170 CCDC66 CD109 CD44 CPED1 CRIPAK CYP19A1 DAB2 DHX58 DLEU2 DNAH10 DOCK9 EBPL ECHDC1 EML6 EPDR1 ERI1 ESPL1 ESR1 EYA4 FADS2 FAM210A FAM3C FGFRL1 FHL3 FTH1P20 FZD7 GATAD1 GIT1 GLDN GREM2 HDAC5 HSD17B13 IBSP IDUA IQGAP1 JAG1 KIAA1530 KLHL17 KREMEN1 L3MBTL2 LEKR1 LIN7C LRRC29 LSMD1 MARK3 MEOX2 MMAA MS4A14 MS4A2 MYH7B PKDCC RASGRF2 RBM6 RERE RHPN2 RMND1 RP11-356J5.12 RP11-500G22.2 RP13-514E23.2 RPL23AP32 RSPO3 SAPS3 SENP7 SEPT5 SERTAD2 SIPA1 SKIV2L2 SLC30A10 SLC8A1 SMG6 SPP1 SPTBN1 SRP54 SUPT3H TIPARP TMEM8A TPCN2 TSPYL6 VNN2 WARS2 WNT2B WNT4 XKR9 ZHX3 ZNF827
Allergy 1.14 4 2 4.4 0.35 6.5e-01 FADS2 IQGAP1 L3MBTL2 RERE
Diabetes (self-reported) 1.22 1 0 0.0 0.00 1.0e+00 RBM6
Hayfever/allergic rhinitis (self-reported) 1.11 1 0 0.0 0.00 1.0e+00 IQGAP1
Fluid intelligence score 0.97 1 1 2.2 0.00 1.0e+00 RBM6
Illnesses of siblings 1.30 1 0 0.0 0.00 1.0e+00 GIT1
Neuroticism score 1.01 1 1 2.2 0.00 1.0e+00 ERI1
Weight 1.57 17 6 13.3 0.23 3.0e-01 AMT CADM1 CRIPAK DAB2 DLEU2 EBPL ERI1 GATAD1 IBSP MYH7B RBM6 SAPS3 SMG6 TMEM8A WNT2B WNT4 ZNF608
Impedance of arm (right) 1.72 21 10 22.2 -0.27 2.1e-01 AC093110.3 BARX1 C4orf14 CADM1 CRIPAK DHX58 DNAH10 ERI1 FZD7 IBSP KREMEN1 L3MBTL2 MARK3 MYH7B RBM6 SAPS3 SMG6 SPTBN1 TIPARP WARS2 WNT2B
Arm fat percentage (right) 1.14 8 4 8.9 0.57 1.4e-01 AMT CADM1 DNAH10 ERI1 GIT1 HDAC5 MARK3 RBM6
Trunk fat-free mass 2.23 22 19 42.2 0.20 2.9e-01 ARFGAP2 C4orf14 CCDC66 CRIPAK DAB2 DLEU2 DNAH10 DOCK9 EBPL FGFRL1 FHL3 GATAD1 IBSP KIAA1530 MYH7B RBM6 RP13-514E23.2 SAPS3 SMG6 SUPT3H WNT4 ZNF827
Hip circumference 1.40 15 6 13.3 -0.40 1.2e-01 DLEU2 DNAH10 ERI1 EYA4 GATAD1 IBSP MYH7B RBM6 RSPO3 TMEM8A TPCN2 WARS2 WNT4 ZHX3 ZNF608
Alcohol intake versus 10 years previously 1.14 1 0 0.0 0.00 1.0e+00 SIPA1
Father's age at death 1.07 1 0 0.0 0.00 1.0e+00 ERI1
Worrier / anxious feelings 1.13 1 1 2.2 0.00 1.0e+00 ERI1
Frequency of tiredness / lethargy in last 2 weeks 1.10 1 0 0.0 0.00 1.0e+00 AMT
Hair/balding pattern: Pattern 3 1.47 2 2 4.4 0.00 1.0e+00 EYA4 ZHX3
Number of live births 1.31 2 2 4.4 0.00 1.0e+00 FADS2 WNT4
Forced expiratory volume in 1-second (FEV1) 1.75 10 5 11.1 -0.27 3.1e-01 BARX1 C4orf14 CRIPAK DLEU2 EBPL ERI1 FHL3 SAPS3 TPCN2 WNT4
Pulse rate 1.47 2 1 2.2 0.00 1.0e+00 AMT LEKR1
Qualifications: A levels/AS levels or equivalent 0.98 3 1 2.2 0.00 1.0e+00 AMT FZD7 RBM6
Mouth/teeth dental problems: Dentures 0.94 1 0 0.0 0.00 1.0e+00 ERI1
Asthma 1.18 2 2 4.4 0.00 1.0e+00 FADS2 RERE
Forced expiratory volume in 1-second (FEV1), Best measure 1.76 9 3 6.7 -0.22 4.3e-01 BARX1 C4orf14 CRIPAK DLEU2 EBPL ERI1 FHL3 SAPS3 WNT4
Impedance of arm (left) 1.60 23 7 15.6 -0.31 1.4e-01 AC093110.3 BARX1 C4orf14 CADM1 CRIPAK DHX58 DNAH10 ERI1 FZD7 IBSP KREMEN1 L3MBTL2 MARK3 MYH7B RBM6 RPL23AP32 SAPS3 SMG6 SPTBN1 SRP54 TIPARP WARS2 WNT2B
Arm fat mass (right) 1.18 10 3 6.7 0.50 1.4e-01 AMT CADM1 DNAH10 ERI1 GIT1 HDAC5 MARK3 RBM6 SMG6 ZNF608
Trunk predicted mass 2.22 22 19 42.2 0.20 3.0e-01 ARFGAP2 C4orf14 CCDC66 CRIPAK DAB2 DLEU2 DNAH10 DOCK9 EBPL FGFRL1 FHL3 GATAD1 IBSP KIAA1530 MYH7B RBM6 RP13-514E23.2 SAPS3 SMG6 SUPT3H WNT4 ZNF827
Standing height 1.96 31 24 53.3 -0.01 9.6e-01 ARFGAP2 C7orf58 CCDC66 CRIPAK DAB2 DLEU2 DNAH10 DOCK9 EBPL EPDR1 ERI1 EYA4 FADS2 FGFRL1 FHL3 GATAD1 GIT1 HSD17B13 IBSP IQGAP1 KIAA1530 MARK3 MYH7B RP13-514E23.2 SAPS3 SIPA1 SUPT3H TPCN2 WNT2B WNT4 ZNF827
Tense / 'highly strung' 1.43 2 1 2.2 0.00 1.0e+00 ERI1 RERE
Hair/balding pattern: Pattern 4 1.65 7 3 6.7 -0.07 8.9e-01 FADS2 IQGAP1 LRRC29 MYH7B SMG6 WARS2 ZHX3
Birth weight of first child 1.34 2 0 0.0 0.00 1.0e+00 TIPARP WNT4
Peak expiratory flow (PEF) 1.50 4 2 4.4 -0.41 5.0e-01 BMP4 DLEU2 ERI1 SAPS3
Gout (self-reported) 1.07 2 0 0.0 0.00 1.0e+00 IBSP SIPA1
Hypothyroidism/myxoedema (self-reported) 1.12 3 1 2.2 0.00 1.0e+00 AKAP11 ERI1 FADS2
Medication: Amlodipine 1.45 1 0 0.0 0.00 1.0e+00 SIPA1
Birth weight 1.85 5 2 4.4 0.44 4.5e-01 KREMEN1 RSPO3 SMG6 TIPARP WNT4
High blood pressure (siblings) 1.40 2 0 0.0 0.00 1.0e+00 GIT1 SMG6
Forced vital capacity (FVC), Best measure 1.84 12 5 11.1 -0.08 7.5e-01 ARFGAP2 BARX1 C4orf14 CRIPAK CYP19A1 DAB2 DLEU2 EBPL FHL3 GIT1 SAPS3 WNT4
Body fat percentage 1.31 12 6 13.3 -0.06 8.6e-01 AC093110.3 AMT DNAH10 GIT1 HDAC5 MARK3 RBM6 RERE SPTBN1 WNT2B ZHX3 ZNF608
Leg fat percentage (right) 1.25 9 6 13.3 0.00 9.9e-01 AMT CADM1 DNAH10 ERI1 GIT1 RBM6 RERE WNT2B ZHX3
Arm fat-free mass (right) 2.09 21 14 31.1 0.34 6.9e-02 C4orf14 CRIPAK DAB2 DLEU2 DNAH10 DOCK9 EBPL ERI1 FGFRL1 FHL3 GATAD1 IBSP KIAA1530 MYH7B RBM6 RP13-514E23.2 SAPS3 SIPA1 SMG6 SUPT3H ZNF608
Comparative body size at age 10 1.24 5 2 4.4 0.72 1.7e-01 ERI1 L3MBTL2 SAPS3 SMG6 WNT2B
Worry too long after embarrassment 0.91 1 1 2.2 0.00 1.0e+00 ERI1
Wheeze or whistling in the chest in last year 1.10 2 1 2.2 0.00 1.0e+00 RBM6 RERE
Age at first live birth 0.86 1 1 2.2 0.00 1.0e+00 RBM6
Qualifications: College or University degree 0.76 4 2 4.4 -0.10 9.0e-01 AMT MYH7B RBM6 RERE
Medication: Blood pressure 1.19 2 0 0.0 0.00 1.0e+00 ERI1 SIPA1
Medication: Ibuprofen 1.10 1 0 0.0 0.00 1.0e+00 FTH1P20
Medication: Allopurinol 1.16 1 0 0.0 0.00 1.0e+00 LSMD1
Mean time to correctly identify matches 1.00 1 1 2.2 0.00 1.0e+00 ARFGAP2
Whole body fat mass 1.29 10 5 11.1 0.13 7.3e-01 AMT DNAH10 GIT1 HDAC5 MARK3 RBM6 RERE WNT2B ZHX3 ZNF608
Leg fat mass (right) 1.28 10 3 6.7 -0.02 9.5e-01 AMT CADM1 DNAH10 ERI1 GIT1 RBM6 RERE WNT2B ZHX3 ZNF608
Arm predicted mass (right) 2.09 20 13 28.9 0.26 1.9e-01 CRIPAK DAB2 DLEU2 DNAH10 DOCK9 EBPL ERI1 FGFRL1 FHL3 GATAD1 IBSP KIAA1530 MYH7B RBM6 RP13-514E23.2 SAPS3 SMG6 SUPT3H WNT4 ZNF608
Pulse rate, automated reading 1.69 9 5 11.1 0.18 6.3e-01 AMT CCDC66 CRIPAK FADS2 LEKR1 MYH7B RBM6 SERTAD2 ZHX3
Alcohol intake frequency. 0.79 2 0 0.0 0.00 1.0e+00 AMT RBM6
Comparative height size at age 10 1.47 15 8 17.8 -0.05 8.4e-01 ARFGAP2 CRIPAK DAB2 DLEU2 DNAH10 EBPL GATAD1 IQGAP1 KIAA1530 MARK3 SAPS3 SUPT3H WARS2 WNT2B WNT4
Suffer from 'nerves' 1.21 2 0 0.0 0.00 1.0e+00 ERI1 SMG6
Overall health rating 0.91 1 0 0.0 0.00 1.0e+00 ZNF608
Chest pain or discomfort 1.00 1 0 0.0 0.00 1.0e+00 SIPA1
Age at last live birth 1.10 1 1 2.2 0.00 1.0e+00 RBM6
Qualifications: NVQ or HND or HNC or equivalent 1.12 1 0 0.0 0.00 1.0e+00 RBM6
Medication: Aspirin 1.16 1 0 0.0 0.00 1.0e+00 FTH1P20
Hypertension (Self-reported) 1.48 8 3 6.7 0.02 9.6e-01 ARFGAP2 ERI1 FTH1P20 KREMEN1 LSMD1 RP13-514E23.2 SIPA1 SMG6
Illnesses of father: Heart disease 1.16 1 0 0.0 0.00 1.0e+00 DNAH10
Forced expiratory volume in 1-second (FEV1), predicted 1.62 2 1 2.2 0.00 1.0e+00 DLEU2 EPDR1
Whole body fat-free mass 2.10 23 16 35.6 0.22 2.4e-01 ARFGAP2 C4orf14 CRIPAK DAB2 DLEU2 DNAH10 DOCK9 EBPL ERI1 FGFRL1 FHL3 GATAD1 IBSP KIAA1530 MYH7B RBM6 RP13-514E23.2 SAPS3 SMG6 SUPT3H WNT4 ZNF608 ZNF827
Leg fat-free mass (right) 1.87 19 13 28.9 0.20 3.2e-01 ARFGAP2 CRIPAK DAB2 DLEU2 DOCK9 EBPL ERI1 FHL3 GATAD1 IBSP KIAA1530 MYH7B RBM6 RP13-514E23.2 SAPS3 SMG6 SUPT3H WNT4 ZNF608
Arm fat percentage (left) 1.21 9 4 8.9 0.48 1.9e-01 AMT CADM1 DNAH10 ERI1 GIT1 HDAC5 MARK3 RBM6 RERE
Mood swings 1.00 1 0 0.0 0.00 1.0e+00 ERI1
Diabetes diagnosed by doctor 1.24 1 0 0.0 0.00 1.0e+00 RBM6
Breast cancer (self-reported) 1.17 1 0 0.0 0.00 1.0e+00 C6orf97
Asthma (self-reported) 1.15 2 2 4.4 0.00 1.0e+00 FADS2 RERE
Osteoporosis (self-reported) 4.00 7 4 8.9 -0.64 1.2e-01 CPED1 DNAH10 ESPL1 GREM2 LIN7C SAPS3 SPP1
Medication: Aspirin 1.20 1 0 0.0 0.00 1.0e+00 FTH1P20
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.00 1 0 0.0 0.00 1.0e+00 WNT4
Whole body water mass 2.11 23 16 35.6 0.22 2.4e-01 ARFGAP2 C4orf14 CRIPAK DAB2 DLEU2 DNAH10 DOCK9 EBPL ERI1 FGFRL1 FHL3 GATAD1 IBSP KIAA1530 MYH7B RBM6 RP13-514E23.2 SAPS3 SMG6 SUPT3H WNT4 ZNF608 ZNF827
Leg predicted mass (right) 1.86 19 13 28.9 0.20 3.3e-01 ARFGAP2 CRIPAK DAB2 DLEU2 DOCK9 EBPL ERI1 FHL3 GATAD1 IBSP KIAA1530 MYH7B RBM6 RP13-514E23.2 SAPS3 SMG6 SUPT3H WNT4 ZNF608
Arm fat mass (left) 1.21 9 3 6.7 0.44 2.4e-01 AMT CADM1 DNAH10 ERI1 GIT1 HDAC5 MARK3 RBM6 ZNF608
Number of self-reported non-cancer illnesses 1.24 1 0 0.0 0.00 1.0e+00 LSMD1
Miserableness 1.08 2 2 4.4 0.00 1.0e+00 ARFGAP2 ERI1
Guilty feelings 1.13 1 0 0.0 0.00 1.0e+00 ERI1
Medication: Blood pressure 1.57 4 2 4.4 0.69 3.1e-01 ERI1 LSMD1 SIPA1 WNT2B
High cholesterol (Self-reported) 1.03 1 0 0.0 0.00 1.0e+00 MS4A14
Medication: Bendroflumethiazide 1.29 1 0 0.0 0.00 1.0e+00 ERI1
Illnesses of father: High blood pressure 1.12 1 0 0.0 0.00 1.0e+00 RP13-514E23.2
Ever smoked 0.84 1 1 2.2 0.00 1.0e+00 C4orf14
Basal metabolic rate 1.98 21 15 33.3 0.27 1.6e-01 ARFGAP2 CRIPAK DAB2 DLEU2 DOCK9 EBPL ERI1 FGFRL1 FHL3 GATAD1 IBSP KIAA1530 MYH7B RBM6 RP13-514E23.2 SAPS3 SMG6 SUPT3H WNT4 ZNF608 ZNF827
Leg fat percentage (left) 1.23 10 5 11.1 0.12 7.5e-01 AMT CADM1 DNAH10 ERI1 GIT1 MARK3 RBM6 RERE WNT2B ZHX3
Arm fat-free mass (left) 2.04 20 12 26.7 0.25 2.1e-01 CRIPAK DAB2 DLEU2 DNAH10 DOCK9 EBPL ERI1 FGFRL1 FHL3 GATAD1 IBSP KIAA1530 MYH7B RBM6 RP13-514E23.2 SAPS3 SMG6 SUPT3H WNT4 ZNF608
Average weekly beer plus cider intake 1.15 1 0 0.0 0.00 1.0e+00 ERI1
Irritability 1.18 1 1 2.2 0.00 1.0e+00 ERI1
Fractured/broken bones in last 5 years 5.49 9 4 8.9 -0.97 3.4e-11 C6orf97 C7orf58 CPED1 CRIPAK FAM3C FGFRL1 HDAC5 RSPO3 TPCN2
Diastolic blood pressure, automated reading 1.62 11 5 11.1 0.21 5.4e-01 AMT EML6 ERI1 LSMD1 RERE RP13-514E23.2 SIPA1 SMG6 SPTBN1 WNT2B ZHX3
Myopia 1.19 2 0 0.0 0.00 1.0e+00 BMP4 FADS2
Vascular/heart problems diagnosed by doctor 1.50 8 4 8.9 0.09 8.4e-01 ARFGAP2 ERI1 FTH1P20 GIT1 KREMEN1 LSMD1 SIPA1 SMG6
Cholesterol lowering medication 1.37 2 0 0.0 0.00 1.0e+00 DNAH10 GIT1
Pain experienced in last month 0.99 1 0 0.0 0.00 1.0e+00 ECHDC1
Basal cell carcinoma (self-reported) 1.30 1 0 0.0 0.00 1.0e+00 SAPS3
Impedance of whole body 1.64 19 10 22.2 -0.41 8.4e-02 AC093110.3 C4orf14 CADM1 CRIPAK DHX58 DNAH10 ERI1 FZD7 IBSP KIAA1530 L3MBTL2 MARK3 MYH7B RBM6 RPL23AP32 SAPS3 SMG6 WARS2 WNT2B
Leg fat mass (left) 1.30 11 3 6.7 0.08 8.2e-01 AMT CADM1 DNAH10 ERI1 GIT1 MARK3 RBM6 RERE WNT2B ZHX3 ZNF608
Arm predicted mass (left) 2.04 20 13 28.9 0.25 2.1e-01 CRIPAK DAB2 DLEU2 DNAH10 DOCK9 EBPL ERI1 FGFRL1 FHL3 GATAD1 IBSP KIAA1530 MYH7B RBM6 RP13-514E23.2 SAPS3 SMG6 SUPT3H ZNF608 ZNF827

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 22 0.63 2.4
GTEx Adipose Visceral Omentum 16 0.79 2.5
GTEx Adrenal Gland 8 0.55 2.2
GTEx Artery Aorta 31 1.04 2.4
GTEx Artery Coronary 4 0.34 2.3
GTEx Artery Tibial 30 0.80 2.6
GTEx Brain Caudate basal ganglia 5 0.54 2.4
GTEx Brain Cerebellar Hemisphere 7 0.47 2.3
GTEx Brain Cerebellum 11 0.55 2.2
GTEx Brain Cortex 6 0.58 2.4
GTEx Brain Frontal Cortex BA9 6 0.65 2.3
GTEx Brain Hippocampus 3 0.57 2.4
GTEx Brain Hypothalamus 1 0.17 2.1
GTEx Brain Nucleus accumbens basal ganglia 7 0.81 2.1
GTEx Brain Putamen basal ganglia 4 0.64 2.3
GTEx Breast Mammary Tissue 13 0.66 2.4
GTEx Breast Mammary Tissue (Male) 8 0.67 2.2
GTEx Breast Mammary Tissue (Female) 10 0.61 2.2
GTEx Cells EBV-transformed lymphocytes 7 0.49 2.4
GTEx Cells Transformed fibroblasts 20 0.48 2.3
GTEx Colon Sigmoid 4 0.27 2.2
GTEx Colon Transverse 16 0.78 2.2
GTEx Esophagus Gastroesophageal Junction 11 0.76 2.3
GTEx Esophagus Mucosa 20 0.60 2.2
GTEx Esophagus Muscularis 23 0.71 2.3
GTEx Heart Atrial Appendage 8 0.51 2.2
GTEx Heart Left Ventricle 13 0.85 2.3
GTEx Liver 2 0.28 2.0
GTEx Lung 20 0.70 2.4
GTEx Muscle Skeletal 13 0.45 2.1
GTEx Nerve Tibial 29 0.67 2.3
GTEx Ovary 5 0.55 2.4
GTEx Pancreas 20 1.23 2.7
GTEx Pituitary 5 0.45 2.3
GTEx Prostate 6 0.72 2.4
GTEx Skin Not Sun Exposed Suprapubic 19 0.77 2.4
GTEx Skin Sun Exposed Lower leg 24 0.66 2.4
GTEx Small Intestine Terminal Ileum 3 0.65 2.5
GTEx Spleen 10 0.71 2.3
GTEx Stomach 7 0.48 2.3
GTEx Testis 21 0.67 2.2
GTEx Thyroid 22 0.55 2.3
GTEx Uterus 3 0.53 2.5
GTEx Vagina 5 0.79 2.4
GTEx Whole Blood 10 0.50 2.2
METSIM Adipose 38 0.82 2.2
NTR Blood 18 0.75 2.4
ROSMAP Brain Pre-frontal Cortex 43 0.98 2.5
YFS Blood 19 0.41 2.0
CommonMind Brain Pre-frontal Cortex 35 0.65 2.2
The Cancer Genome Atlas Bladder Urothelial Carcinoma 13 0.79 2.4
The Cancer Genome Atlas Breast Invasive Carcinoma 39 0.88 2.4
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 6 0.55 2.1
The Cancer Genome Atlas Colon Adenocarcinoma 16 0.77 2.3
The Cancer Genome Atlas Esophageal Carcinoma 4 0.58 2.2
The Cancer Genome Atlas Glioblastoma Multiforme 7 0.68 2.5
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 16 0.59 2.1
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 32 0.78 2.3
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 12 0.59 2.2
The Cancer Genome Atlas Brain Lower Grade Glioma 25 0.58 2.1
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 5 0.45 2.1
The Cancer Genome Atlas Lung Adenocarcinoma 13 0.44 2.2
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 16 0.64 2.3
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 10 0.63 2.5
The Cancer Genome Atlas Pancreatic Adenocarcinoma 11 0.66 2.5
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 14 1.06 2.4
The Cancer Genome Atlas Prostate Adenocarcinoma 23 0.50 2.2
The Cancer Genome Atlas Rectum Adenocarcinoma 4 0.58 2.1
The Cancer Genome Atlas Soft Tissue Sarcoma 8 0.75 2.3
The Cancer Genome Atlas Skin Cutaneous Melanoma 4 0.75 2.4
The Cancer Genome Atlas Stomach Adenocarcinoma 12 0.71 2.3
The Cancer Genome Atlas Testicular Germ Cell Tumors 10 0.78 2.2
The Cancer Genome Atlas Thyroid Carcinoma 27 0.52 2.1
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 5 0.98 2.4