Hub : Traits :

Heel bone mineral density (BMD) T-score, automated (left)

1023 significantly associated models · 256 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	752566	1567206	1	1	1.6e-08	1.6e-07	1.0e+00	100	KLHL17
2	1	7715776	9571422	2	1	1.7e-11	1.3e-09	2.7e-01	97	RERE
3	1	15123100	16552772	1	1	1.0e-08	1.4e-08	2.3e-01	96	CASP9
4	1	22197336	22718991	1	1	1.4e-17	3.7e-22	1.6e-25	-16	WNT4
5	1	37730550	39167106	2	1	2.6e-09	3.0e-08	2.3e-01	95	FHL3
6	1	112312154	114196883	4	1	1.4e-14	1.4e-14	1.0e-02	89	WNT2B
7	1	118878656	120380990	1	1	2.2e-09	2.7e-10	1.1e-03	73	WARS2
8	1	219166366	220808921	1	1	1.3e-09	1.4e-10	3.5e-02	89	SLC30A10
9	1	239954252	241470634	1	1	5.5e-37	5.2e-50	2.2e-16	70	GREM2
10	2	39636469	41534961	1	1	6.9e-09	1.3e-12	4.5e-08	40	SLC8A1
11	2	41579722	42984340	1	1	1.3e-08	1.6e-19	1.5e-12	39	PKDCC
12	2	53647729	55895321	8	13	7.7e-39	7.6e-55	NaN	NaN	AC093110.3 ACYP2 C2orf73 EML6 RPL23AP32 SPTBN1 TSPYL6
13	2	64168232	65573478	1	1	4.9e-09	1.4e-08	9.5e-02	91	SERTAD2
14	2	181042370	182430120	1	1	2.1e-07	1.7e-06	4.0e-01	97	FTH1P20
15	2	202200575	203592180	1	1	3.1e-11	1.8e-32	4.0e-29	11	FZD7
16	3	48515079	50800146	15	2	1.0e-11	8.3e-12	3.7e-01	98	AMT RBM6
17	3	55894951	57350441	1	1	3.0e-07	2.1e-09	7.8e-04	69	CCDC66
18	3	100350244	101922655	1	1	1.7e-07	2.4e-07	9.0e-03	74	SENP7
19	3	155695485	157456920	4	2	2.7e-17	2.6e-15	2.8e-01	98	LEKR1 TIPARP
20	4	69713	2058475	13	10	1.8e-39	8.5e-31	NaN	NaN	CRIPAK FGFRL1 IDUA KIAA1530
21	4	57587795	58088682	1	1	1.2e-07	8.2e-09	2.2e-02	84	C4orf14
22	4	85698680	89692911	7	4	4.1e-14	8.8e-14	1.0e+00	100	HSD17B13 IBSP RP13-514E23.2 SPP1
23	4	144882744	147552337	4	2	3.0e-10	4.5e-11	1.8e-05	58	MMAA ZNF827
24	5	39132847	39670061	1	1	8.4e-08	8.3e-08	7.5e-04	60	DAB2
25	5	53906103	55410585	1	1	7.8e-08	1.2e-07	4.5e-01	98	SKIV2L2
26	5	80008704	80761967	1	1	2.7e-12	2.0e-12	1.0e+00	100	RASGRF2
27	5	123274918	124774701	1	1	3.1e-07	1.7e-06	5.0e-03	66	ZNF608
28	6	44079216	46043561	1	1	4.3e-19	8.1e-26	1.9e-12	55	SUPT3H
29	6	73710903	75236060	1	1	1.7e-09	2.6e-11	4.2e-03	82	CD109
30	6	126892049	128359362	3	2	5.8e-74	1.5e-89	2.7e-13	87	ECHDC1 RSPO3
31	6	132368241	134546685	3	4	1.6e-11	2.1e-36	2.3e-18	52	C6orf192 EYA4 VNN2
32	6	151118271	153120904	4	8	2.8e-93	4.7e-76	NaN	NaN	C6orf97 CCDC170 ESR1 RMND1
33	7	14953576	16424863	1	1	3.3e-09	5.4e-14	2.6e-08	45	MEOX2
34	7	26871554	28479059	2	1	8.0e-09	1.5e-14	6.1e-11	28	AC004549.6
35	7	37260712	38687833	1	6	2.4e-27	5.0e-41	1.8e-01	99	EPDR1
36	7	91380845	93160671	2	1	2.9e-09	3.6e-08	1.1e-02	78	GATAD1
37	7	119892061	121729795	5	8	1.8e-238	0.0e+00	NaN	NaN	C7orf58 CPED1 FAM3C
38	8	8092025	13120332	39	1	2.0e-22	5.7e-26	1.9e-06	80	ERI1
39	8	70788124	72399360	4	1	1.1e-09	4.8e-10	1.8e-08	18	XKR9
40	9	96102832	97571455	2	1	9.2e-10	6.0e-08	1.0e-01	91	BARX1
41	10	122989048	124407934	1	1	4.1e-08	6.7e-07	4.8e-02	84	RP11-500G22.2
42	11	26818083	28220506	1	1	1.8e-13	4.0e-26	6.5e-16	42	LIN7C
43	11	34460769	35949179	1	1	5.6e-09	4.3e-09	1.0e+00	100	CD44
44	11	45945837	48285906	13	1	9.3e-16	5.4e-17	2.2e-03	87	ARFGAP2
45	11	59239839	62326265	7	3	1.1e-08	2.5e-09	3.7e-01	98	FADS2 MS4A14 MS4A2
46	11	64669105	66116911	2	1	1.5e-12	2.5e-08	1.2e-01	92	SIPA1
47	11	67339278	69623641	9	2	3.7e-17	4.5e-23	5.0e-05	83	SAPS3 TPCN2
48	11	111354161	112921923	2	2	6.5e-31	3.8e-45	1.8e-13	73	BCO2 RP11-356J5.12
49	11	114340771	116072203	1	2	1.4e-12	1.4e-16	6.2e-01	100	CADM1
50	12	52990150	54388473	2	1	3.5e-08	2.5e-08	1.0e+00	100	ESPL1
51	12	123558705	125196704	4	1	1.9e-10	3.4e-08	7.0e-02	89	DNAH10
52	13	42149812	43594717	1	1	2.7e-07	6.3e-27	3.5e-21	23	AKAP11
53	13	49557805	51390447	2	4	2.4e-10	2.3e-09	1.0e+00	100	DLEU2 EBPL
54	13	98746497	100437143	2	2	3.4e-16	2.9e-18	2.5e-02	93	DOCK9
55	14	34754717	36195312	1	1	1.1e-07	1.1e-07	1.0e+00	100	SRP54
56	14	53731553	55118795	1	1	1.7e-32	1.7e-33	5.8e-07	83	BMP4
57	14	103161201	105211221	9	1	1.5e-18	1.1e-18	1.0e+00	100	MARK3
58	15	51255019	51946100	2	2	7.3e-14	6.0e-15	2.9e-04	78	CYP19A1 GLDN
59	15	90208219	91886448	3	1	5.0e-10	1.1e-09	3.2e-01	97	IQGAP1
60	16	86671	1115377	3	1	8.6e-09	3.5e-11	1.6e-04	68	TMEM8A
61	16	66062381	68125316	7	1	8.9e-11	1.8e-13	8.3e-05	71	LRRC29
62	17	1263564	2899908	2	2	9.3e-20	3.0e-25	7.0e-03	93	SMG6
63	17	7084911	8484683	2	1	1.3e-08	3.0e-07	5.5e-01	99	LSMD1
64	17	27244473	28642380	2	1	1.6e-08	5.6e-09	9.2e-02	92	GIT1
65	17	39559539	40930095	1	1	1.4e-07	1.9e-05	1.0e-03	41	DHX58
66	17	41393295	43332365	8	1	5.9e-17	2.4e-17	1.0e+00	100	HDAC5
67	18	12966058	14385836	1	1	6.8e-08	2.3e-25	4.2e-19	26	FAM210A
68	19	32670184	34392158	6	3	1.0e-45	2.7e-45	3.7e-03	96	RHPN2
69	20	10374093	10903755	1	1	2.2e-07	1.4e-13	3.5e-14	-5	JAG1
70	20	32819871	34556216	5	1	3.1e-10	1.2e-09	1.0e+00	100	MYH7B
71	20	39567774	40193393	1	1	1.7e-08	1.1e-10	1.6e-03	76	ZHX3
72	22	19003938	20330744	1	1	7.8e-10	1.6e-42	1.6e-34	20	SEPT5
73	22	28792887	30261219	3	1	4.8e-23	3.8e-23	1.0e+00	100	KREMEN1
74	22	40789606	42301748	2	1	4.7e-10	2.6e-10	1.0e+00	100	L3MBTL2

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Heel T-Score	48.39	101	101	224.4	0.99	1.6e-119	AC004549.6 AC093110.3 ACYP2 AKAP11 AMT ARFGAP2 BARX1 BCO2 BMP4 C2orf73 C4orf14 C6orf192 C6orf97 C7orf58 CADM1 CASP9 CCDC170 CCDC66 CD109 CD44 CPED1 CRIPAK CYP19A1 DAB2 DHX58 DLEU2 DNAH10 DOCK9 EBPL ECHDC1 EML6 EPDR1 ESPL1 ESR1 EYA4 FADS2 FAM210A FAM3C FGFRL1 FHL3 FTH1P20 FZD7 GATAD1 GIT1 GLDN GREM2 HDAC5 HSD17B13 IBSP IDUA IQGAP1 JAG1 KIAA1530 KLHL17 KREMEN1 L3MBTL2 LEKR1 LIN7C LRRC29 LSMD1 MARK3 MEOX2 MMAA MS4A14 MS4A2 MYH7B PKDCC RASGRF2 RBM6 RERE RHPN2 RMND1 RP11-356J5.12 RP11-500G22.2 RP13-514E23.2 RPL23AP32 RSPO3 SAPS3 SENP7 SEPT5 SERTAD2 SIPA1 SKIV2L2 SLC30A10 SLC8A1 SMG6 SPP1 SPTBN1 SRP54 SUPT3H TIPARP TMEM8A TPCN2 TSPYL6 VNN2 WARS2 WNT2B WNT4 XKR9 ZHX3 ZNF827
Heel bone mineral density (BMD) T-score, automated (right)	33.50	102	88	195.6	1.00	8.4e-158	AC004549.6 AC093110.3 ACYP2 AKAP11 AMT ARFGAP2 BARX1 BCO2 BMP4 C2orf73 C4orf14 C6orf192 C6orf97 C7orf58 CADM1 CASP9 CCDC170 CCDC66 CD109 CD44 CPED1 CRIPAK CYP19A1 DAB2 DHX58 DLEU2 DNAH10 DOCK9 EBPL ECHDC1 EML6 EPDR1 ERI1 ESPL1 ESR1 EYA4 FADS2 FAM210A FAM3C FGFRL1 FHL3 FTH1P20 FZD7 GATAD1 GIT1 GLDN GREM2 HDAC5 HSD17B13 IBSP IDUA IQGAP1 JAG1 KIAA1530 KLHL17 KREMEN1 L3MBTL2 LEKR1 LIN7C LRRC29 LSMD1 MARK3 MEOX2 MMAA MS4A14 MS4A2 MYH7B PKDCC RASGRF2 RBM6 RERE RHPN2 RMND1 RP11-356J5.12 RP11-500G22.2 RP13-514E23.2 RPL23AP32 RSPO3 SAPS3 SENP7 SEPT5 SERTAD2 SIPA1 SKIV2L2 SLC30A10 SLC8A1 SMG6 SPP1 SPTBN1 SRP54 SUPT3H TIPARP TMEM8A TPCN2 TSPYL6 VNN2 WARS2 WNT2B WNT4 XKR9 ZHX3 ZNF827
Fractured/broken bones in last 5 years	5.49	9	4	8.9	-0.97	3.4e-11	C6orf97 C7orf58 CPED1 CRIPAK FAM3C FGFRL1 HDAC5 RSPO3 TPCN2
Osteoporosis (self-reported)	4.00	7	4	8.9	-0.64	1.2e-01	CPED1 DNAH10 ESPL1 GREM2 LIN7C SAPS3 SPP1
Waist Hip Ratio (WHR)	3.71	19	13	28.9	0.15	5.3e-01	AMT C7orf58 CPED1 CRIPAK CYP19A1 DLEU2 DNAH10 FAM3C FGFRL1 IDUA MYH7B RSPO3 SIPA1 SLC30A10 TIPARP TMEM8A WARS2 WNT4 XKR9
Trunk fat-free mass	2.23	22	19	42.2	0.20	2.9e-01	ARFGAP2 C4orf14 CCDC66 CRIPAK DAB2 DLEU2 DNAH10 DOCK9 EBPL FGFRL1 FHL3 GATAD1 IBSP KIAA1530 MYH7B RBM6 RP13-514E23.2 SAPS3 SMG6 SUPT3H WNT4 ZNF827
Trunk predicted mass	2.22	22	19	42.2	0.20	3.0e-01	ARFGAP2 C4orf14 CCDC66 CRIPAK DAB2 DLEU2 DNAH10 DOCK9 EBPL FGFRL1 FHL3 GATAD1 IBSP KIAA1530 MYH7B RBM6 RP13-514E23.2 SAPS3 SMG6 SUPT3H WNT4 ZNF827
Sitting height	2.17	22	16	35.6	0.13	4.7e-01	ARFGAP2 CD109 CRIPAK DAB2 DLEU2 DOCK9 EBPL EPDR1 ERI1 EYA4 FHL3 GATAD1 HSD17B13 IBSP KREMEN1 LRRC29 MYH7B SAPS3 SUPT3H TIPARP TPCN2 WNT4
Whole body water mass	2.11	23	16	35.6	0.22	2.4e-01	ARFGAP2 C4orf14 CRIPAK DAB2 DLEU2 DNAH10 DOCK9 EBPL ERI1 FGFRL1 FHL3 GATAD1 IBSP KIAA1530 MYH7B RBM6 RP13-514E23.2 SAPS3 SMG6 SUPT3H WNT4 ZNF608 ZNF827
Whole body fat-free mass	2.10	23	16	35.6	0.22	2.4e-01	ARFGAP2 C4orf14 CRIPAK DAB2 DLEU2 DNAH10 DOCK9 EBPL ERI1 FGFRL1 FHL3 GATAD1 IBSP KIAA1530 MYH7B RBM6 RP13-514E23.2 SAPS3 SMG6 SUPT3H WNT4 ZNF608 ZNF827
Arm fat-free mass (right)	2.09	21	14	31.1	0.34	6.9e-02	C4orf14 CRIPAK DAB2 DLEU2 DNAH10 DOCK9 EBPL ERI1 FGFRL1 FHL3 GATAD1 IBSP KIAA1530 MYH7B RBM6 RP13-514E23.2 SAPS3 SIPA1 SMG6 SUPT3H ZNF608
Arm predicted mass (right)	2.09	20	13	28.9	0.26	1.9e-01	CRIPAK DAB2 DLEU2 DNAH10 DOCK9 EBPL ERI1 FGFRL1 FHL3 GATAD1 IBSP KIAA1530 MYH7B RBM6 RP13-514E23.2 SAPS3 SMG6 SUPT3H WNT4 ZNF608
Arm fat-free mass (left)	2.04	20	12	26.7	0.25	2.1e-01	CRIPAK DAB2 DLEU2 DNAH10 DOCK9 EBPL ERI1 FGFRL1 FHL3 GATAD1 IBSP KIAA1530 MYH7B RBM6 RP13-514E23.2 SAPS3 SMG6 SUPT3H WNT4 ZNF608
Arm predicted mass (left)	2.04	20	13	28.9	0.25	2.1e-01	CRIPAK DAB2 DLEU2 DNAH10 DOCK9 EBPL ERI1 FGFRL1 FHL3 GATAD1 IBSP KIAA1530 MYH7B RBM6 RP13-514E23.2 SAPS3 SMG6 SUPT3H ZNF608 ZNF827
Height	2.02	45	34	75.6	-0.07	5.9e-01	ARFGAP2 C2orf73 C4orf14 C7orf58 CADM1 CCDC66 CPED1 CRIPAK CYP19A1 DAB2 DLEU2 DNAH10 DOCK9 EBPL EML6 EPDR1 EYA4 FADS2 FGFRL1 FHL3 GATAD1 GIT1 HSD17B13 IBSP IQGAP1 KIAA1530 KREMEN1 LRRC29 MARK3 MYH7B RMND1 RP11-500G22.2 RP13-514E23.2 RPL23AP32 SAPS3 SIPA1 SLC8A1 SPP1 SPTBN1 SUPT3H TPCN2 WARS2 WNT2B WNT4 ZNF827
Basal metabolic rate	1.98	21	15	33.3	0.27	1.6e-01	ARFGAP2 CRIPAK DAB2 DLEU2 DOCK9 EBPL ERI1 FGFRL1 FHL3 GATAD1 IBSP KIAA1530 MYH7B RBM6 RP13-514E23.2 SAPS3 SMG6 SUPT3H WNT4 ZNF608 ZNF827
Standing height	1.96	31	24	53.3	-0.01	9.6e-01	ARFGAP2 C7orf58 CCDC66 CRIPAK DAB2 DLEU2 DNAH10 DOCK9 EBPL EPDR1 ERI1 EYA4 FADS2 FGFRL1 FHL3 GATAD1 GIT1 HSD17B13 IBSP IQGAP1 KIAA1530 MARK3 MYH7B RP13-514E23.2 SAPS3 SIPA1 SUPT3H TPCN2 WNT2B WNT4 ZNF827
Leg fat-free mass (left)	1.87	19	12	26.7	0.19	3.5e-01	ARFGAP2 CRIPAK DAB2 DLEU2 DOCK9 EBPL ERI1 FHL3 GATAD1 IBSP KIAA1530 MYH7B RBM6 RP13-514E23.2 SAPS3 SMG6 SUPT3H WNT4 ZNF608
Leg fat-free mass (right)	1.87	19	13	28.9	0.20	3.2e-01	ARFGAP2 CRIPAK DAB2 DLEU2 DOCK9 EBPL ERI1 FHL3 GATAD1 IBSP KIAA1530 MYH7B RBM6 RP13-514E23.2 SAPS3 SMG6 SUPT3H WNT4 ZNF608
Leg predicted mass (left)	1.86	19	12	26.7	0.19	3.5e-01	ARFGAP2 CRIPAK DAB2 DLEU2 DOCK9 EBPL ERI1 FHL3 GATAD1 IBSP KIAA1530 MYH7B RBM6 RP13-514E23.2 SAPS3 SMG6 SUPT3H WNT4 ZNF608
Leg predicted mass (right)	1.86	19	13	28.9	0.20	3.3e-01	ARFGAP2 CRIPAK DAB2 DLEU2 DOCK9 EBPL ERI1 FHL3 GATAD1 IBSP KIAA1530 MYH7B RBM6 RP13-514E23.2 SAPS3 SMG6 SUPT3H WNT4 ZNF608
Birth weight	1.85	5	2	4.4	0.44	4.5e-01	KREMEN1 RSPO3 SMG6 TIPARP WNT4
Forced vital capacity (FVC), Best measure	1.84	12	5	11.1	-0.08	7.5e-01	ARFGAP2 BARX1 C4orf14 CRIPAK CYP19A1 DAB2 DLEU2 EBPL FHL3 GIT1 SAPS3 WNT4
Systolic blood pressure, automated reading	1.83	10	7	15.6	0.43	2.2e-01	ERI1 ESR1 FHL3 GATAD1 RERE RP13-514E23.2 SIPA1 SMG6 WNT2B ZNF827
Forced vital capacity (FVC)	1.83	14	5	11.1	-0.02	9.4e-01	ARFGAP2 BARX1 C4orf14 CRIPAK CYP19A1 DLEU2 EBPL FGFRL1 FHL3 GIT1 SAPS3 SIPA1 TPCN2 WNT4
Forced expiratory volume in 1-second (FEV1), Best measure	1.76	9	3	6.7	-0.22	4.3e-01	BARX1 C4orf14 CRIPAK DLEU2 EBPL ERI1 FHL3 SAPS3 WNT4
Forced expiratory volume in 1-second (FEV1)	1.75	10	5	11.1	-0.27	3.1e-01	BARX1 C4orf14 CRIPAK DLEU2 EBPL ERI1 FHL3 SAPS3 TPCN2 WNT4
Impedance of arm (right)	1.72	21	10	22.2	-0.27	2.1e-01	AC093110.3 BARX1 C4orf14 CADM1 CRIPAK DHX58 DNAH10 ERI1 FZD7 IBSP KREMEN1 L3MBTL2 MARK3 MYH7B RBM6 SAPS3 SMG6 SPTBN1 TIPARP WARS2 WNT2B
Breast Cancer	1.71	1	1	2.2	0.00	1.0e+00	C6orf97
Systolic Blood Pressure	1.70	14	10	22.2	0.17	5.7e-01	ARFGAP2 BMP4 CASP9 ESR1 FHL3 FTH1P20 GATAD1 LSMD1 RERE RP13-514E23.2 SIPA1 SMG6 WNT2B ZNF827
Pulse rate, automated reading	1.69	9	5	11.1	0.18	6.3e-01	AMT CCDC66 CRIPAK FADS2 LEKR1 MYH7B RBM6 SERTAD2 ZHX3
Hair/balding pattern: Pattern 4	1.65	7	3	6.7	-0.07	8.9e-01	FADS2 IQGAP1 LRRC29 MYH7B SMG6 WARS2 ZHX3
Impedance of whole body	1.64	19	10	22.2	-0.41	8.4e-02	AC093110.3 C4orf14 CADM1 CRIPAK DHX58 DNAH10 ERI1 FZD7 IBSP KIAA1530 L3MBTL2 MARK3 MYH7B RBM6 RPL23AP32 SAPS3 SMG6 WARS2 WNT2B
Forced expiratory volume in 1-second (FEV1), predicted	1.62	2	1	2.2	0.00	1.0e+00	DLEU2 EPDR1
Diastolic blood pressure, automated reading	1.62	11	5	11.1	0.21	5.4e-01	AMT EML6 ERI1 LSMD1 RERE RP13-514E23.2 SIPA1 SMG6 SPTBN1 WNT2B ZHX3
Impedance of arm (left)	1.60	23	7	15.6	-0.31	1.4e-01	AC093110.3 BARX1 C4orf14 CADM1 CRIPAK DHX58 DNAH10 ERI1 FZD7 IBSP KREMEN1 L3MBTL2 MARK3 MYH7B RBM6 RPL23AP32 SAPS3 SMG6 SPTBN1 SRP54 TIPARP WARS2 WNT2B
Hair/balding pattern: Pattern 2	1.59	1	1	2.2	0.00	1.0e+00	EYA4
Impedance of leg (right)	1.57	16	9	20.0	-0.49	5.3e-02	CADM1 CRIPAK DHX58 ERI1 IBSP KIAA1530 L3MBTL2 MARK3 RBM6 RPL23AP32 SAPS3 SMG6 WARS2 WNT2B WNT4 ZHX3
Hand grip strength (right)	1.57	3	3	6.7	-0.54	1.6e-01	C7orf58 CRIPAK DNAH10
Weight	1.57	17	6	13.3	0.23	3.0e-01	AMT CADM1 CRIPAK DAB2 DLEU2 EBPL ERI1 GATAD1 IBSP MYH7B RBM6 SAPS3 SMG6 TMEM8A WNT2B WNT4 ZNF608
Medication: Blood pressure	1.57	4	2	4.4	0.69	3.1e-01	ERI1 LSMD1 SIPA1 WNT2B
Impedance of leg (left)	1.56	13	9	20.0	-0.45	1.2e-01	CADM1 DHX58 ERI1 IBSP L3MBTL2 MARK3 RBM6 RPL23AP32 SAPS3 SMG6 WARS2 WNT2B WNT4
Hand grip strength (left)	1.53	4	1	2.2	0.33	3.9e-01	C7orf58 CRIPAK DNAH10 SAPS3
Triglycerides	1.50	4	1	2.2	0.11	8.9e-01	DNAH10 FADS2 HSD17B13 RSPO3
High blood pressure	1.50	9	3	6.7	-0.13	7.4e-01	ARFGAP2 C6orf97 ERI1 FTH1P20 KREMEN1 LSMD1 RP13-514E23.2 SIPA1 SMG6
Peak expiratory flow (PEF)	1.50	4	2	4.4	-0.41	5.0e-01	BMP4 DLEU2 ERI1 SAPS3
Vascular/heart problems diagnosed by doctor	1.50	8	4	8.9	0.09	8.4e-01	ARFGAP2 ERI1 FTH1P20 GIT1 KREMEN1 LSMD1 SIPA1 SMG6
Hypertension (Self-reported)	1.48	8	3	6.7	0.02	9.6e-01	ARFGAP2 ERI1 FTH1P20 KREMEN1 LSMD1 RP13-514E23.2 SIPA1 SMG6
HDL Cholesterol	1.47	5	2	4.4	-0.23	7.2e-01	ARFGAP2 DNAH10 FADS2 RSPO3 SIPA1
Hair/balding pattern: Pattern 3	1.47	2	2	4.4	0.00	1.0e+00	EYA4 ZHX3
Pulse rate	1.47	2	1	2.2	0.00	1.0e+00	AMT LEKR1
Comparative height size at age 10	1.47	15	8	17.8	-0.05	8.4e-01	ARFGAP2 CRIPAK DAB2 DLEU2 DNAH10 EBPL GATAD1 IQGAP1 KIAA1530 MARK3 SAPS3 SUPT3H WARS2 WNT2B WNT4
Medication: Amlodipine	1.45	1	0	0.0	0.00	1.0e+00	SIPA1
Bilateral oophorectomy (both ovaries removed)	1.43	1	1	2.2	0.00	1.0e+00	WNT4
Tense / 'highly strung'	1.43	2	1	2.2	0.00	1.0e+00	ERI1 RERE
Lung FEV1/FVC ratio	1.42	7	5	11.1	-0.39	3.4e-01	BMP4 FAM3C GIT1 L3MBTL2 RERE SERTAD2 SMG6
Neuroticism (2016)	1.41	1	1	2.2	0.00	1.0e+00	ERI1
Hip circumference	1.40	15	6	13.3	-0.40	1.2e-01	DLEU2 DNAH10 ERI1 EYA4 GATAD1 IBSP MYH7B RBM6 RSPO3 TMEM8A TPCN2 WARS2 WNT4 ZHX3 ZNF608
High blood pressure (siblings)	1.40	2	0	0.0	0.00	1.0e+00	GIT1 SMG6
Cholesterol lowering medication	1.37	2	0	0.0	0.00	1.0e+00	DNAH10 GIT1
Trunk fat percentage	1.35	13	6	13.3	-0.22	4.6e-01	AC093110.3 AMT CPED1 DNAH10 EML6 GIT1 HDAC5 RBM6 RERE SPTBN1 WNT2B ZHX3 ZNF608
Trunk fat mass	1.35	9	5	11.1	0.10	7.9e-01	AMT DLEU2 DNAH10 HDAC5 RBM6 RERE WNT2B ZHX3 ZNF608
Blood Platelet Count	1.34	20	14	31.1	0.21	3.7e-01	ARFGAP2 C4orf14 CCDC66 DOCK9 FADS2 GATAD1 GLDN HDAC5 HSD17B13 MARK3 MS4A14 RP13-514E23.2 RSPO3 SENP7 SEPT5 SERTAD2 SMG6 TIPARP WNT2B ZHX3
Birth weight of first child	1.34	2	0	0.0	0.00	1.0e+00	TIPARP WNT4
Diabetes (mother)	1.32	1	0	0.0	0.00	1.0e+00	ZHX3
Rheumatoid Arthritis	1.31	1	0	0.0	0.00	1.0e+00	FADS2
Taking other prescription medications	1.31	1	0	0.0	0.00	1.0e+00	RBM6
Number of live births	1.31	2	2	4.4	0.00	1.0e+00	FADS2 WNT4
Body fat percentage	1.31	12	6	13.3	-0.06	8.6e-01	AC093110.3 AMT DNAH10 GIT1 HDAC5 MARK3 RBM6 RERE SPTBN1 WNT2B ZHX3 ZNF608
Illnesses of siblings	1.30	1	0	0.0	0.00	1.0e+00	GIT1
Basal cell carcinoma (self-reported)	1.30	1	0	0.0	0.00	1.0e+00	SAPS3
Leg fat mass (left)	1.30	11	3	6.7	0.08	8.2e-01	AMT CADM1 DNAH10 ERI1 GIT1 MARK3 RBM6 RERE WNT2B ZHX3 ZNF608
Cardiovascular Disease	1.29	9	3	6.7	0.05	9.0e-01	AC093110.3 FTH1P20 GATAD1 GIT1 KREMEN1 LSMD1 MARK3 RP13-514E23.2 SIPA1
Waist circumference	1.29	11	3	6.7	0.50	1.2e-01	AMT CADM1 CRIPAK GIT1 MARK3 RBM6 RSPO3 SIPA1 SMG6 TIPARP ZNF608
Whole body fat mass	1.29	10	5	11.1	0.13	7.3e-01	AMT DNAH10 GIT1 HDAC5 MARK3 RBM6 RERE WNT2B ZHX3 ZNF608
Medication: Bendroflumethiazide	1.29	1	0	0.0	0.00	1.0e+00	ERI1
Crohns Disease (2017)	1.28	4	1	2.2	0.31	6.9e-01	AMT MARK3 RSPO3 ZHX3
Respiratory disease	1.28	3	2	4.4	0.00	1.0e+00	C4orf14 FADS2 RERE
Serious illness, injury or assault to yourself	1.28	1	0	0.0	0.00	1.0e+00	SPTBN1
Leg fat mass (right)	1.28	10	3	6.7	-0.02	9.5e-01	AMT CADM1 DNAH10 ERI1 GIT1 RBM6 RERE WNT2B ZHX3 ZNF608
Leg fat percentage (right)	1.25	9	6	13.3	0.00	9.9e-01	AMT CADM1 DNAH10 ERI1 GIT1 RBM6 RERE WNT2B ZHX3
Schizophrenia (2014)	1.24	2	1	2.2	0.00	1.0e+00	RERE SMG6
Hearing difficulty/problems with background noise	1.24	1	0	0.0	0.00	1.0e+00	ARFGAP2
Comparative body size at age 10	1.24	5	2	4.4	0.72	1.7e-01	ERI1 L3MBTL2 SAPS3 SMG6 WNT2B
Diabetes diagnosed by doctor	1.24	1	0	0.0	0.00	1.0e+00	RBM6
Number of self-reported non-cancer illnesses	1.24	1	0	0.0	0.00	1.0e+00	LSMD1
Allergy or Eczema	1.23	3	2	4.4	0.00	1.0e+00	IQGAP1 L3MBTL2 RERE
Chronotype (morning person)	1.23	2	2	4.4	0.58	3.1e-01	CRIPAK RP11-500G22.2
Hayfever, allergic rhinitis or eczema	1.23	2	2	4.4	0.00	1.0e+00	IQGAP1 RERE
Leg fat percentage (left)	1.23	10	5	11.1	0.12	7.5e-01	AMT CADM1 DNAH10 ERI1 GIT1 MARK3 RBM6 RERE WNT2B ZHX3
Alzheimer’s Disease (including proxy)	1.22	1	1	2.2	0.00	1.0e+00	MS4A2
LDL Cholesterol	1.22	1	1	2.2	0.00	1.0e+00	FADS2
Diabetes (self-reported)	1.22	1	0	0.0	0.00	1.0e+00	RBM6
Suffer from 'nerves'	1.21	2	0	0.0	0.00	1.0e+00	ERI1 SMG6
Arm fat percentage (left)	1.21	9	4	8.9	0.48	1.9e-01	AMT CADM1 DNAH10 ERI1 GIT1 HDAC5 MARK3 RBM6 RERE
Arm fat mass (left)	1.21	9	3	6.7	0.44	2.4e-01	AMT CADM1 DNAH10 ERI1 GIT1 HDAC5 MARK3 RBM6 ZNF608
Blood White Count	1.20	18	12	26.7	-0.23	3.3e-01	C4orf14 CYP19A1 DNAH10 EYA4 FADS2 FTH1P20 GIT1 IQGAP1 LSMD1 MS4A2 RBM6 RERE RP13-514E23.2 SMG6 SPTBN1 TIPARP TPCN2 ZHX3
Medication: Aspirin	1.20	1	0	0.0	0.00	1.0e+00	FTH1P20
Coronary Artery Disease (CAD)	1.19	1	0	0.0	0.00	1.0e+00	DNAH10
Lung FVC	1.19	11	6	13.3	-0.09	7.7e-01	BMP4 C4orf14 CD109 CYP19A1 EBPL GIT1 MYH7B SAPS3 WNT2B WNT4 ZNF827
Medication: Blood pressure	1.19	2	0	0.0	0.00	1.0e+00	ERI1 SIPA1
Myopia	1.19	2	0	0.0	0.00	1.0e+00	BMP4 FADS2
Relative age of first facial hair	1.18	2	0	0.0	0.00	1.0e+00	CYP19A1 SIPA1
Nervous feelings	1.18	2	1	2.2	0.00	1.0e+00	ERI1 SMG6
Asthma	1.18	2	2	4.4	0.00	1.0e+00	FADS2 RERE
Arm fat mass (right)	1.18	10	3	6.7	0.50	1.4e-01	AMT CADM1 DNAH10 ERI1 GIT1 HDAC5 MARK3 RBM6 SMG6 ZNF608
Irritability	1.18	1	1	2.2	0.00	1.0e+00	ERI1
Crohns Disease (2012)	1.17	1	1	2.2	0.00	1.0e+00	AMT
Breast cancer (self-reported)	1.17	1	0	0.0	0.00	1.0e+00	C6orf97
Hypothyroidism (self reported)	1.16	4	2	4.4	-1.00	4.7e-03	AKAP11 FADS2 FHL3 GIT1
Medication: Allopurinol	1.16	1	0	0.0	0.00	1.0e+00	LSMD1
Medication: Aspirin	1.16	1	0	0.0	0.00	1.0e+00	FTH1P20
Illnesses of father: Heart disease	1.16	1	0	0.0	0.00	1.0e+00	DNAH10
Asthma (self-reported)	1.15	2	2	4.4	0.00	1.0e+00	FADS2 RERE
Average weekly beer plus cider intake	1.15	1	0	0.0	0.00	1.0e+00	ERI1
Frequency of depressed mood in last 2 weeks	1.14	1	0	0.0	0.00	1.0e+00	ERI1
Allergy	1.14	4	2	4.4	0.35	6.5e-01	FADS2 IQGAP1 L3MBTL2 RERE
Arm fat percentage (right)	1.14	8	4	8.9	0.57	1.4e-01	AMT CADM1 DNAH10 ERI1 GIT1 HDAC5 MARK3 RBM6
Alcohol intake versus 10 years previously	1.14	1	0	0.0	0.00	1.0e+00	SIPA1
Body mass index (BMI)	1.13	9	5	11.1	0.46	2.1e-01	AMT CADM1 DNAH10 ERI1 GIT1 MARK3 RBM6 SMG6 ZNF608
Worrier / anxious feelings	1.13	1	1	2.2	0.00	1.0e+00	ERI1
Guilty feelings	1.13	1	0	0.0	0.00	1.0e+00	ERI1
Maternal smoking around birth	1.12	1	0	0.0	0.00	1.0e+00	MARK3
Hypothyroidism/myxoedema (self-reported)	1.12	3	1	2.2	0.00	1.0e+00	AKAP11 ERI1 FADS2
Qualifications: NVQ or HND or HNC or equivalent	1.12	1	0	0.0	0.00	1.0e+00	RBM6
Illnesses of father: High blood pressure	1.12	1	0	0.0	0.00	1.0e+00	RP13-514E23.2
Hayfever/allergic rhinitis (self-reported)	1.11	1	0	0.0	0.00	1.0e+00	IQGAP1
Irritable Bowel Disease (IBD)	1.10	4	1	2.2	0.01	9.9e-01	AMT MARK3 WNT2B ZHX3
Frequency of tiredness / lethargy in last 2 weeks	1.10	1	0	0.0	0.00	1.0e+00	AMT
Wheeze or whistling in the chest in last year	1.10	2	1	2.2	0.00	1.0e+00	RBM6 RERE
Medication: Ibuprofen	1.10	1	0	0.0	0.00	1.0e+00	FTH1P20
Age at last live birth	1.10	1	1	2.2	0.00	1.0e+00	RBM6
Lupus	1.08	2	1	2.2	0.00	1.0e+00	CD44 ERI1
Miserableness	1.08	2	2	4.4	0.00	1.0e+00	ARFGAP2 ERI1
Father's age at death	1.07	1	0	0.0	0.00	1.0e+00	ERI1
Gout (self-reported)	1.07	2	0	0.0	0.00	1.0e+00	IBSP SIPA1
Number of incorrect matches in round	1.06	1	0	0.0	0.00	1.0e+00	EBPL
Depression (Nagel 2018)	1.05	1	0	0.0	0.00	1.0e+00	RERE
Age at First Birth	1.05	1	1	2.2	0.00	1.0e+00	RBM6
Type 2 Diabetes (T2D) (2018)	1.05	1	0	0.0	0.00	1.0e+00	MARK3
Number of treatments/medications taken	1.05	2	0	0.0	0.00	1.0e+00	FADS2 RBM6
Age when periods started (menarche)	1.05	2	1	2.2	0.00	1.0e+00	RP11-500G22.2 TIPARP
Schizophrenia (2018)	1.04	1	0	0.0	0.00	1.0e+00	RERE
BMI	1.03	10	7	15.6	0.29	4.2e-01	AMT CADM1 DNAH10 GIT1 MARK3 RBM6 SAPS3 SMG6 WARS2 ZNF608
Medication: Levothyroxine sodium	1.03	3	0	0.0	0.00	1.0e+00	AKAP11 ERI1 FADS2
High cholesterol (Self-reported)	1.03	1	0	0.0	0.00	1.0e+00	MS4A14
Blood Red Count	1.02	21	12	26.7	-0.09	7.0e-01	AMT CCDC66 DNAH10 DOCK9 EML6 ESPL1 FADS2 FTH1P20 FZD7 GATAD1 GIT1 HDAC5 LSMD1 MARK3 RPL23AP32 RSPO3 SAPS3 SERTAD2 SMG6 SPTBN1 TIPARP
Smoking Status	1.02	4	2	4.4	0.10	9.0e-01	C4orf14 MARK3 RERE SMG6
Bipolar Disorder (2018)	1.01	1	0	0.0	0.00	1.0e+00	MYH7B
Past tobacco smoking	1.01	2	1	2.2	0.00	1.0e+00	C4orf14 MYH7B
Neuroticism score	1.01	1	1	2.2	0.00	1.0e+00	ERI1
Bipolar Disorder or Schizophrenia	1.00	1	0	0.0	0.00	1.0e+00	MYH7B
Mean time to correctly identify matches	1.00	1	1	2.2	0.00	1.0e+00	ARFGAP2
Chest pain or discomfort	1.00	1	0	0.0	0.00	1.0e+00	SIPA1
Mood swings	1.00	1	0	0.0	0.00	1.0e+00	ERI1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.00	1	0	0.0	0.00	1.0e+00	WNT4
Worry (Nagel 2018)	0.99	1	0	0.0	0.00	1.0e+00	SMG6
Pain experienced in last month	0.99	1	0	0.0	0.00	1.0e+00	ECHDC1
Reaction Time	0.98	2	0	0.0	0.00	1.0e+00	ARFGAP2 DNAH10
Qualifications: A levels/AS levels or equivalent	0.98	3	1	2.2	0.00	1.0e+00	AMT FZD7 RBM6
Fluid intelligence score	0.97	1	1	2.2	0.00	1.0e+00	RBM6
Blood Eosinophil Count	0.95	18	7	15.6	0.00	9.9e-01	AKAP11 AMT C4orf14 C6orf97 DLEU2 EBPL EML6 FADS2 GATAD1 L3MBTL2 LRRC29 MARK3 MS4A14 RERE RMND1 SAPS3 SENP7 SIPA1
Mouth/teeth dental problems: Dentures	0.94	1	0	0.0	0.00	1.0e+00	ERI1
Fed-up feelings	0.93	2	1	2.2	0.00	1.0e+00	ARFGAP2 ERI1
Sensitivity / hurt feelings	0.92	1	1	2.2	0.00	1.0e+00	ERI1
Worry too long after embarrassment	0.91	1	1	2.2	0.00	1.0e+00	ERI1
Overall health rating	0.91	1	0	0.0	0.00	1.0e+00	ZNF608
Verbal and Numeric Reasoning (VNR)	0.90	1	1	2.2	0.00	1.0e+00	RBM6
Ulcerative Colitis (UC)	0.89	1	0	0.0	0.00	1.0e+00	ZHX3
Intelligence (Savage-Jansen 2018)	0.88	4	1	2.2	-0.86	1.4e-01	AMT DLEU2 MARK3 RBM6
Age at first live birth	0.86	1	1	2.2	0.00	1.0e+00	RBM6
Depressed Affect (Nagel 2018)	0.85	2	1	2.2	0.00	1.0e+00	ARFGAP2 RERE
Relative age voice broke	0.84	1	0	0.0	0.00	1.0e+00	AMT
Ever smoked	0.84	1	1	2.2	0.00	1.0e+00	C4orf14
Neuroticism (Nagel 2018)	0.83	2	0	0.0	0.00	1.0e+00	ARFGAP2 RERE
Neuroticism	0.80	2	0	0.0	0.00	1.0e+00	ARFGAP2 RERE
Alcohol intake frequency.	0.79	2	0	0.0	0.00	1.0e+00	AMT RBM6
Qualifications: College or University degree	0.76	4	2	4.4	-0.10	9.0e-01	AMT MYH7B RBM6 RERE
Hair Pigment	0.61	11	8	17.8	0.32	3.4e-01	ARFGAP2 C4orf14 CD44 FADS2 LIN7C MARK3 MYH7B SAPS3 SIPA1 SPTBN1 TPCN2
Tanning	0.46	3	3	6.7	0.00	1.0e+00	LEKR1 MYH7B TPCN2

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Pancreas	20	1.23	2.7
GTEx	Artery Tibial	30	0.80	2.6
GTEx	Adipose Visceral Omentum	16	0.79	2.5
GTEx	Small Intestine Terminal Ileum	3	0.65	2.5
GTEx	Uterus	3	0.53	2.5
ROSMAP	Brain Pre-frontal Cortex	43	0.98	2.5
The Cancer Genome Atlas	Glioblastoma Multiforme	7	0.68	2.5
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	10	0.63	2.5
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	11	0.66	2.5
GTEx	Adipose Subcutaneous	22	0.63	2.4
GTEx	Artery Aorta	31	1.04	2.4
GTEx	Brain Caudate basal ganglia	5	0.54	2.4
GTEx	Brain Cortex	6	0.58	2.4
GTEx	Brain Hippocampus	3	0.57	2.4
GTEx	Breast Mammary Tissue	13	0.66	2.4
GTEx	Cells EBV-transformed lymphocytes	7	0.49	2.4
GTEx	Lung	20	0.70	2.4
GTEx	Ovary	5	0.55	2.4
GTEx	Prostate	6	0.72	2.4
GTEx	Skin Not Sun Exposed Suprapubic	19	0.77	2.4
GTEx	Skin Sun Exposed Lower leg	24	0.66	2.4
GTEx	Vagina	5	0.79	2.4
NTR	Blood	18	0.75	2.4
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	13	0.79	2.4
The Cancer Genome Atlas	Breast Invasive Carcinoma	39	0.88	2.4
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	14	1.06	2.4
The Cancer Genome Atlas	Skin Cutaneous Melanoma	4	0.75	2.4
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	5	0.98	2.4
GTEx	Artery Coronary	4	0.34	2.3
GTEx	Brain Cerebellar Hemisphere	7	0.47	2.3
GTEx	Brain Frontal Cortex BA9	6	0.65	2.3
GTEx	Brain Putamen basal ganglia	4	0.64	2.3
GTEx	Cells Transformed fibroblasts	20	0.48	2.3
GTEx	Esophagus Gastroesophageal Junction	11	0.76	2.3
GTEx	Esophagus Muscularis	23	0.71	2.3
GTEx	Heart Left Ventricle	13	0.85	2.3
GTEx	Nerve Tibial	29	0.67	2.3
GTEx	Pituitary	5	0.45	2.3
GTEx	Spleen	10	0.71	2.3
GTEx	Stomach	7	0.48	2.3
GTEx	Thyroid	22	0.55	2.3
The Cancer Genome Atlas	Colon Adenocarcinoma	16	0.77	2.3
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	32	0.78	2.3
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	16	0.64	2.3
The Cancer Genome Atlas	Soft Tissue Sarcoma	8	0.75	2.3
The Cancer Genome Atlas	Stomach Adenocarcinoma	12	0.71	2.3
GTEx	Adrenal Gland	8	0.55	2.2
GTEx	Brain Cerebellum	11	0.55	2.2
GTEx	Breast Mammary Tissue (Male)	8	0.67	2.2
GTEx	Breast Mammary Tissue (Female)	10	0.61	2.2
GTEx	Colon Sigmoid	4	0.27	2.2
GTEx	Colon Transverse	16	0.78	2.2
GTEx	Esophagus Mucosa	20	0.60	2.2
GTEx	Heart Atrial Appendage	8	0.51	2.2
GTEx	Testis	21	0.67	2.2
GTEx	Whole Blood	10	0.50	2.2
METSIM	Adipose	38	0.82	2.2
CommonMind	Brain Pre-frontal Cortex	35	0.65	2.2
The Cancer Genome Atlas	Esophageal Carcinoma	4	0.58	2.2
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	12	0.59	2.2
The Cancer Genome Atlas	Lung Adenocarcinoma	13	0.44	2.2
The Cancer Genome Atlas	Prostate Adenocarcinoma	23	0.50	2.2
The Cancer Genome Atlas	Testicular Germ Cell Tumors	10	0.78	2.2
GTEx	Brain Hypothalamus	1	0.17	2.1
GTEx	Brain Nucleus accumbens basal ganglia	7	0.81	2.1
GTEx	Muscle Skeletal	13	0.45	2.1
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	6	0.55	2.1
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	16	0.59	2.1
The Cancer Genome Atlas	Brain Lower Grade Glioma	25	0.58	2.1
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	5	0.45	2.1
The Cancer Genome Atlas	Rectum Adenocarcinoma	4	0.58	2.1
The Cancer Genome Atlas	Thyroid Carcinoma	27	0.52	2.1
GTEx	Liver	2	0.28	2.0
YFS	Blood	19	0.41	2.0