Best TWAS P=4.32e-13 · Best GWAS P=4.46e-24 conditioned to 7.06e-11
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | ALG10 | 0.06 | 0.04 | lasso | 6 | 0.02 | 3.5e-02 | 7.2 | -7.2 | 4.3e-13 | -0.51 | 0.07 | 0.89 | TRUE |
| 2 | GTEx | Cells Transformed fibroblasts | ALG10 | 0.05 | 0.04 | lasso | 2 | 0.04 | 5.6e-04 | 6.3 | -6.6 | 3.2e-11 | -0.47 | 0.56 | 0.38 | FALSE |
| 3 | METSIM | Adipose | ALG10 | 0.05 | 0.04 | blup | 224 | 0.05 | 4.2e-08 | 8.3 | -5.3 | 1.2e-07 | -0.33 | 0.04 | 0.96 | TRUE |
| 4 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ALG10 | 0.06 | 0.04 | blup | 26 | 0.05 | 3.0e-06 | 5.8 | -6.6 | 4.4e-11 | -0.53 | 0.02 | 0.97 | FALSE |
| 5 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | ALG10 | 0.12 | -0.01 | blup | 26 | 0.02 | 8.9e-02 | 5.8 | -6.2 | 5.2e-10 | -0.48 | 0.01 | 0.35 | FALSE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | ALG10 | 0.13 | 0.04 | lasso | 1 | 0.04 | 1.4e-04 | 5.6 | -5.6 | 2.7e-08 | -0.43 | 0.42 | 0.12 | FALSE |