[Hub]/) : Traits : Hand grip strength (left) :

chr6:129,638,583-131,163,098

Best TWAS P=4.9e-19 · Best GWAS P=2.07e-16 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous L3MBTL3 0.20 0.08 lasso 4 0.09 1.1e-07 8.2 8.8 1.0e-18 0.94 0.00 1.00 FALSE
2 GTEx Adipose Visceral Omentum L3MBTL3 0.14 0.12 lasso 2 0.15 2.8e-08 8.2 8.7 2.3e-18 0.94 0.00 1.00 FALSE
3 GTEx Breast Mammary Tissue L3MBTL3 0.31 0.25 lasso 7 0.23 2.8e-12 8.2 8.6 9.1e-18 0.97 0.00 1.00 FALSE
4 GTEx Breast Mammary Tissue RP11-73O6.3 0.27 0.22 lasso 9 0.22 1.5e-11 8.2 8.5 2.7e-17 0.97 0.00 1.00 FALSE
5 GTEx Breast Mammary Tissue (Male) L3MBTL3 0.31 0.24 lasso 6 0.23 5.5e-06 8.2 8.3 8.8e-17 0.94 0.00 0.98 FALSE
6 GTEx Breast Mammary Tissue (Male) RP11-73O6.3 0.33 0.17 lasso 4 0.12 1.3e-03 8.2 8.4 5.1e-17 0.94 0.01 0.95 FALSE
7 GTEx Breast Mammary Tissue (Female) L3MBTL3 0.30 0.13 lasso 5 0.14 4.5e-05 6.8 8.5 1.9e-17 0.93 0.01 0.98 FALSE
8 GTEx Breast Mammary Tissue (Female) RP11-73O6.3 0.29 0.08 lasso 5 0.10 5.7e-04 7.4 8.5 2.9e-17 0.90 0.01 0.96 FALSE
9 GTEx Cells EBV-transformed lymphocytes L3MBTL3 0.28 0.08 lasso 10 0.03 4.4e-02 8.2 8.3 9.4e-17 0.85 0.01 0.96 FALSE
10 GTEx Colon Transverse L3MBTL3 0.27 0.13 lasso 8 0.20 8.0e-10 8.2 7.8 5.5e-15 0.88 0.00 1.00 FALSE
11 GTEx Colon Transverse RP11-73O6.3 0.19 0.09 lasso 2 0.06 1.2e-03 8.2 8.3 9.0e-17 0.99 0.00 1.00 FALSE
12 GTEx Esophagus Mucosa L3MBTL3 0.26 0.18 lasso 2 0.23 2.7e-15 7.4 8.4 4.0e-17 0.93 0.00 1.00 FALSE
13 GTEx Lung L3MBTL3 0.37 0.34 lasso 4 0.38 4.1e-30 8.2 8.7 2.9e-18 0.96 0.00 1.00 FALSE
14 GTEx Lung RP11-73O6.3 0.15 0.08 lasso 5 0.12 2.2e-09 8.2 8.7 3.2e-18 0.93 0.00 1.00 FALSE
15 GTEx Nerve Tibial L3MBTL3 0.30 0.23 lasso 4 0.22 2.3e-15 8.2 8.6 9.0e-18 0.99 0.00 1.00 FALSE
16 GTEx Pancreas L3MBTL3 0.32 0.17 lasso 4 0.23 4.4e-10 8.2 8.6 5.4e-18 0.98 0.00 1.00 FALSE
17 GTEx Pituitary L3MBTL3 0.45 0.31 lasso 8 0.29 5.1e-08 6.8 7.7 1.1e-14 0.85 0.01 0.99 FALSE
18 GTEx Pituitary RP11-73O6.3 0.48 0.07 lasso 7 0.16 8.2e-05 6.8 6.9 5.3e-12 0.78 0.01 0.98 FALSE
19 GTEx Prostate L3MBTL3 0.35 0.27 lasso 5 0.17 5.9e-05 8.2 8.4 4.4e-17 0.97 0.00 0.99 FALSE
20 GTEx Skin Not Sun Exposed Suprapubic L3MBTL3 0.26 0.12 lasso 4 0.12 4.0e-07 6.1 7.8 5.3e-15 0.92 0.00 1.00 FALSE
21 GTEx Skin Sun Exposed Lower leg L3MBTL3 0.25 0.25 lasso 9 0.24 1.4e-19 8.2 8.3 1.0e-16 0.97 0.00 1.00 FALSE
22 GTEx Small Intestine Terminal Ileum L3MBTL3 0.37 0.20 lasso 4 0.17 1.3e-04 8.2 8.0 8.7e-16 0.98 0.00 0.98 FALSE
23 GTEx Spleen L3MBTL3 0.64 0.34 enet 14 0.48 6.4e-14 7.4 8.6 1.1e-17 0.87 0.02 0.98 FALSE
24 GTEx Spleen RP11-73O6.3 0.45 0.43 enet 21 0.42 7.7e-12 7.4 8.5 1.2e-17 0.82 0.05 0.95 FALSE
25 GTEx Stomach L3MBTL3 0.36 0.18 enet 27 0.20 1.1e-09 7.6 8.2 2.4e-16 0.77 0.02 0.98 FALSE
26 GTEx Stomach RP11-73O6.3 0.21 0.12 lasso 6 0.06 5.9e-04 7.6 6.8 1.3e-11 0.73 0.07 0.75 FALSE
27 GTEx Testis L3MBTL3 0.41 0.22 lasso 8 0.30 9.2e-14 8.2 7.0 2.9e-12 0.90 0.00 1.00 FALSE
28 GTEx Thyroid L3MBTL3 0.40 0.39 enet 9 0.43 2.8e-35 8.2 8.7 2.4e-18 0.95 0.00 1.00 FALSE
29 GTEx Thyroid RP11-73O6.3 0.18 0.15 lasso 3 0.20 2.3e-15 7.7 8.7 3.1e-18 0.91 0.00 1.00 FALSE
30 GTEx Whole Blood L3MBTL3 0.22 0.20 lasso 9 0.20 5.1e-18 8.2 8.4 4.5e-17 0.98 0.00 1.00 FALSE
31 GTEx Whole Blood RP11-73O6.3 0.15 0.06 lasso 8 0.04 1.1e-04 8.2 8.9 4.9e-19 0.97 0.00 1.00 TRUE
32 METSIM Adipose L3MBTL3 0.13 0.12 enet 22 0.12 4.8e-18 7.4 6.8 1.3e-11 0.72 0.40 0.60 FALSE
33 ROSMAP Brain Pre-frontal Cortex L3MBTL3 0.14 0.07 blup 609 0.08 3.8e-10 8.2 7.5 5.2e-14 0.72 0.00 1.00 FALSE
34 YFS Blood L3MBTL3 0.28 0.22 blup 614 0.27 1.2e-88 7.4 7.4 1.3e-13 0.74 0.40 0.60 FALSE
35 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma L3MBTL3 0.06 0.01 blup 114 0.04 4.0e-03 7.4 5.9 3.9e-09 0.77 0.02 0.85 FALSE