Hub : Traits :

Hand grip strength (left)

1483 significantly associated models · 258 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	9576675	11137778	2	2	7.1e-09	1.7e-08	1.0e+00	100	CORT KIF1B
2	1	22712328	24201643	1	1	2.0e-07	1.6e-07	1.0e+00	100	LUZP1
3	1	149854324	151227371	1	1	2.1e-07	3.9e-07	1.0e+00	100	ADAMTSL4
4	1	183961643	185416670	1	1	1.7e-07	3.8e-07	1.0e-01	90	EDEM3
5	1	204982713	206329620	5	1	1.9e-14	7.5e-14	2.7e-01	98	NUCKS1
6	1	227217340	228663659	4	1	8.0e-12	1.9e-13	3.4e-03	84	JMJD4
7	2	23604114	25889403	7	8	4.5e-15	2.3e-14	NaN	NaN	ADCY3 DNAJC27 NCOA1 RP11-443B20.1 TP53I3
8	2	43417083	44920960	1	1	4.6e-09	2.0e-10	1.3e-02	85	LRPPRC
9	2	67709195	69180661	2	1	7.7e-08	9.0e-08	1.0e+00	100	RP11-474G23.2
10	2	69978290	71471456	1	2	4.4e-16	5.1e-14	3.7e-02	92	TGFA
11	2	134513621	137435625	8	1	1.2e-13	3.4e-12	2.0e-01	96	LOC100129961
12	2	152099885	152836845	1	1	2.1e-07	6.8e-07	2.4e-01	94	NEB
13	3	52047421	53860103	4	1	6.1e-10	1.6e-09	1.0e+00	100	RFT1
14	3	84767271	86367480	1	1	6.7e-10	9.4e-10	1.0e+00	100	CADM2
15	3	128788778	129284415	1	1	2.3e-07	1.5e-05	9.4e-01	100	H1FX
16	3	140350567	141867638	1	1	8.0e-10	1.7e-11	1.0e+00	100	ZBTB38
17	4	644410	2058475	2	1	1.9e-08	1.2e-06	1.1e-02	73	CRIPAK
18	4	17104059	18507692	2	1	5.2e-17	4.9e-19	1.9e-04	82	DCAF16
19	5	129885843	132839137	15	6	9.1e-15	7.7e-14	1.0e+00	100	AC034220.3 CDC42SE2 P4HA2 PDLIM4 RAPGEF6 SLC22A4
20	6	1967240	3450266	1	1	3.3e-08	4.1e-07	1.0e+00	100	MYLK4
21	6	12595275	13990267	1	1	2.4e-07	4.1e-07	1.0e+00	100	RP1-257A7.5
22	6	80374293	81763771	1	1	1.4e-07	3.3e-06	4.6e-02	82	RP11-250B2.6
23	6	129638583	131163098	2	1	4.9e-19	2.1e-16	1.0e+00	100	RP11-73O6.3
24	7	99220083	100932330	12	1	1.3e-10	1.4e-07	3.8e-01	97	PILRA
25	7	119935156	121630503	1	1	5.1e-08	2.3e-08	4.4e-03	74	C7orf58
26	7	149847287	151252618	2	1	3.2e-08	4.0e-14	1.9e-07	52	TMEM176A
27	9	126844856	128643415	6	1	2.0e-10	9.5e-10	1.0e+00	100	GOLGA1
28	10	78845149	80383574	2	1	1.9e-07	1.7e-08	3.0e-02	85	RP13-39P12.3
29	10	80443273	81901722	2	1	1.9e-09	1.5e-07	1.3e-02	77	ZCCHC24
30	10	98832260	99329418	1	1	3.7e-08	1.5e-06	6.4e-01	99	FRAT1
31	10	102640116	105282664	10	7	3.1e-14	1.4e-10	NaN	NaN	C10orf26 C10orf76 NPM3 SUFU TMEM180
32	11	46622392	48485877	10	1	1.1e-13	1.3e-12	1.5e-01	96	FNBP4
33	11	65670510	67856510	2	4	1.4e-15	8.8e-15	1.0e+00	100	CCS RAD9A
34	11	73024914	75075866	3	3	2.2e-15	2.5e-17	7.0e-01	100	C2CD3 POLD3
35	11	76602665	78216992	3	1	6.5e-13	1.2e-10	4.6e-01	99	AQP11
36	12	14220891	16190627	8	1	9.0e-26	4.3e-25	1.0e-01	98	MGP
37	12	46514123	47009428	1	1	2.5e-07	6.0e-08	8.6e-02	90	SLC38A2
38	12	47671905	49061511	1	1	6.9e-08	3.2e-07	1.0e-01	90	TMEM106C
39	13	50600027	52109040	1	1	4.2e-08	1.2e-16	9.3e-11	39	DLEU7
40	14	74245607	76089054	4	2	2.5e-08	3.2e-08	3.3e-01	97	NPC2 YLPM1
41	15	73524629	75038482	2	3	6.6e-13	9.4e-13	1.1e-05	62	LOXL1-AS1 PML
42	15	77023336	78474476	1	1	3.1e-09	2.7e-09	1.3e-02	82	HMG20A
43	16	1381714	2952423	5	2	1.1e-12	5.6e-14	4.0e-01	99	CASKIN1 SLC9A3R2
44	16	3969463	5510848	3	1	1.1e-07	2.9e-07	3.9e-01	97	C16orf71
45	16	19022448	20423000	2	1	1.1e-07	4.6e-07	1.2e-04	42	AC002550.5
46	16	24614505	25167985	1	1	1.2e-07	5.1e-07	8.0e-01	100	SLC5A11
47	16	29412503	31026427	10	1	1.1e-09	3.0e-09	2.7e-01	97	YPEL3
48	16	69062879	70473934	4	1	3.1e-13	1.6e-12	2.2e-02	90	NOB1
49	16	89013848	90172696	1	1	2.9e-08	3.9e-06	1.6e-04	33	CHMP1A
50	17	36211659	37644854	2	1	6.7e-15	9.6e-15	1.0e+00	100	PSMB3
51	17	41946180	47357969	36	4	2.7e-15	2.4e-13	2.9e-02	91	ADAM11 FZD2 HOXB2 WNT3
52	17	61106371	62694738	3	1	7.6e-10	5.0e-10	1.0e+00	100	CD79B
53	18	45873080	47686517	2	2	2.2e-10	2.5e-12	2.0e-02	89	C18orf32 DYM
54	18	52209411	54028036	1	1	1.6e-07	1.0e-14	1.0e-10	30	TCF4
55	19	1916392	2466607	1	1	2.8e-07	1.8e-07	1.0e+00	100	DOT1L
56	19	37123595	39002725	5	1	9.1e-08	3.5e-08	7.1e-04	62	ZNF573
57	19	52002729	52501321	1	1	8.8e-08	1.3e-10	4.3e-06	49	FPR1
58	20	9925555	11347455	1	1	1.4e-07	7.0e-06	3.3e-06	-7	JAG1
59	20	32254831	35029669	27	7	5.5e-29	1.9e-28	NaN	NaN	CEP250 GDF5 GGT7 MAP1LC3A PIGU
60	20	46838455	48340036	1	1	1.2e-08	2.2e-08	1.0e+00	100	ARFGEF2
61	22	40500313	41004384	1	1	1.3e-07	2.9e-08	6.1e-05	48	ADSL
62	22	41720697	43226599	2	1	1.5e-07	4.0e-07	4.5e-01	98	CYP2D6

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Hand grip strength (right)	14.27	81	67	148.9	0.99	5.8e-88	AC034220.3 ADAM11 ADAMTSL4 ADCY3 AQP11 ARFGEF2 C10orf26 C10orf76 C18orf32 C2CD3 C7orf58 CADM2 CASKIN1 CCS CD79B CDC42SE2 CEP250 CHMP1A CORT CRIPAK DCAF16 DLEU7 DNAJC27 DOT1L DYM EDEM3 FNBP4 FPR1 FRAT1 FZD2 GDF5 GGT7 GOLGA1 H1FX HMG20A HOXB2 JAG1 JMJD4 KIF1B LOC100129961 LOXL1-AS1 LRPPRC LUZP1 MAP1LC3A MGP MYLK4 NCOA1 NEB NOB1 NPC2 NPM3 NUCKS1 P4HA2 PDLIM4 PIGU PILRA PML POLD3 PSMB3 RAD9A RAPGEF6 RFT1 RP11-250B2.6 RP11-443B20.1 RP11-474G23.2 RP11-73O6.3 RP13-39P12.3 SLC22A4 SLC5A11 SLC9A3R2 SUFU TGFA TMEM106C TMEM176A TMEM180 TP53I3 WNT3 YPEL3 ZBTB38 ZCCHC24 ZNF573
Height	12.94	70	65	144.4	0.85	1.1e-23	AC002550.5 AC034220.3 ADAM11 ADCY3 AQP11 ARFGEF2 C10orf26 C16orf71 C18orf32 C7orf58 CASKIN1 CCS CD79B CDC42SE2 CEP250 CHMP1A CRIPAK DCAF16 DLEU7 DNAJC27 DOT1L DYM EDEM3 FNBP4 FZD2 GDF5 GGT7 H1FX HOXB2 JAG1 JMJD4 KIF1B LOXL1-AS1 LUZP1 MAP1LC3A MGP NCOA1 NOB1 NPC2 NUCKS1 P4HA2 PDLIM4 PIGU PILRA PML POLD3 PSMB3 RAD9A RAPGEF6 RFT1 RP11-250B2.6 RP11-443B20.1 RP11-474G23.2 RP11-73O6.3 RP13-39P12.3 SLC22A4 SLC38A2 SLC5A11 SLC9A3R2 SUFU TCF4 TMEM106C TMEM176A TMEM180 TP53I3 WNT3 YPEL3 ZBTB38 ZCCHC24 ZNF573
Standing height	12.67	64	61	135.6	0.89	2.6e-26	AC034220.3 ADAM11 ADCY3 AQP11 ARFGEF2 C10orf26 C16orf71 C18orf32 C7orf58 CASKIN1 CCS CD79B CDC42SE2 CEP250 CHMP1A CRIPAK DCAF16 DLEU7 DNAJC27 DOT1L DYM EDEM3 FNBP4 FZD2 GDF5 GGT7 H1FX JAG1 JMJD4 KIF1B LOXL1-AS1 LUZP1 MAP1LC3A MGP NCOA1 NOB1 NPC2 NUCKS1 P4HA2 PDLIM4 PIGU PML POLD3 PSMB3 RAD9A RAPGEF6 RFT1 RP11-250B2.6 RP11-443B20.1 RP11-474G23.2 RP11-73O6.3 RP13-39P12.3 SLC22A4 SLC38A2 SLC5A11 SLC9A3R2 SUFU TMEM176A TMEM180 TP53I3 WNT3 YPEL3 ZBTB38 ZCCHC24
Sitting height	11.88	55	52	115.6	0.91	8.8e-26	AC034220.3 ADAM11 ADCY3 ARFGEF2 C10orf26 C18orf32 CASKIN1 CD79B CDC42SE2 CEP250 CHMP1A CRIPAK DCAF16 DLEU7 DNAJC27 DOT1L DYM FNBP4 FZD2 GDF5 GGT7 H1FX JAG1 JMJD4 LOXL1-AS1 LUZP1 MAP1LC3A MGP NCOA1 NOB1 NUCKS1 P4HA2 PDLIM4 PIGU PML POLD3 PSMB3 RAD9A RAPGEF6 RFT1 RP11-250B2.6 RP11-443B20.1 RP11-474G23.2 RP11-73O6.3 RP13-39P12.3 SLC22A4 SLC38A2 SLC9A3R2 SUFU TMEM176A TMEM180 TP53I3 WNT3 ZBTB38 ZCCHC24
Comparative body size at age 10	11.45	11	9	20.0	-0.55	4.4e-02	AC002550.5 ADCY3 ADSL CADM2 DNAJC27 DOT1L FNBP4 NCOA1 NUCKS1 RP11-443B20.1 YPEL3
Comparative height size at age 10	10.18	51	43	95.6	0.89	5.7e-22	AC034220.3 ADAM11 ADCY3 ARFGEF2 C10orf26 C16orf71 C18orf32 CASKIN1 CCS CD79B CEP250 CHMP1A CRIPAK DCAF16 DLEU7 DNAJC27 DOT1L DYM FZD2 GDF5 GGT7 H1FX JMJD4 KIF1B LOXL1-AS1 MAP1LC3A NCOA1 NUCKS1 P4HA2 PDLIM4 PIGU PML PSMB3 RAD9A RAPGEF6 RFT1 RP11-250B2.6 RP11-443B20.1 RP11-73O6.3 RP13-39P12.3 SLC22A4 SLC9A3R2 SUFU TCF4 TMEM176A TMEM180 TP53I3 WNT3 YPEL3 ZBTB38 ZCCHC24
Trunk fat-free mass	9.56	53	47	104.4	0.93	2.1e-25	AC002550.5 AC034220.3 ADAM11 ADCY3 ADSL ARFGEF2 C10orf26 C18orf32 CADM2 CASKIN1 CD79B CDC42SE2 CEP250 CHMP1A CRIPAK CYP2D6 DCAF16 DLEU7 DOT1L DYM GDF5 GGT7 H1FX JMJD4 LOXL1-AS1 LUZP1 MAP1LC3A MGP NCOA1 NUCKS1 P4HA2 PDLIM4 PIGU PML POLD3 PSMB3 RAD9A RAPGEF6 RP11-250B2.6 RP11-474G23.2 RP11-73O6.3 RP13-39P12.3 SLC22A4 SLC38A2 SLC5A11 SLC9A3R2 SUFU TMEM176A TMEM180 TP53I3 YPEL3 ZBTB38 ZCCHC24
Trunk predicted mass	9.52	53	47	104.4	0.93	3.2e-25	AC002550.5 AC034220.3 ADAM11 ADCY3 ADSL ARFGEF2 C10orf26 C18orf32 CADM2 CASKIN1 CD79B CDC42SE2 CEP250 CHMP1A CRIPAK CYP2D6 DCAF16 DLEU7 DOT1L DYM GDF5 GGT7 H1FX JMJD4 LOXL1-AS1 LUZP1 MAP1LC3A MGP NCOA1 NUCKS1 P4HA2 PDLIM4 PIGU PML POLD3 PSMB3 RAD9A RAPGEF6 RP11-250B2.6 RP11-474G23.2 RP11-73O6.3 RP13-39P12.3 SLC22A4 SLC38A2 SLC5A11 SLC9A3R2 SUFU TMEM176A TMEM180 TP53I3 YPEL3 ZBTB38 ZCCHC24
Whole body fat-free mass	8.68	50	46	102.2	0.93	8.5e-25	AC002550.5 AC034220.3 ADAM11 ADSL ARFGEF2 C10orf26 C18orf32 CADM2 CASKIN1 CD79B CDC42SE2 CEP250 CRIPAK CYP2D6 DCAF16 DLEU7 DOT1L DYM FZD2 GDF5 GGT7 H1FX JMJD4 LOXL1-AS1 LUZP1 MAP1LC3A MGP NCOA1 NUCKS1 P4HA2 PDLIM4 PIGU PSMB3 RAD9A RAPGEF6 RP11-250B2.6 RP11-474G23.2 RP11-73O6.3 RP13-39P12.3 SLC22A4 SLC38A2 SLC5A11 SLC9A3R2 SUFU TMEM176A TMEM180 TP53I3 YPEL3 ZBTB38 ZCCHC24
Whole body water mass	8.61	49	46	102.2	0.94	1.1e-24	AC002550.5 AC034220.3 ADAM11 ADSL ARFGEF2 C10orf26 C18orf32 CADM2 CASKIN1 CD79B CDC42SE2 CEP250 CRIPAK CYP2D6 DCAF16 DLEU7 DOT1L DYM GDF5 GGT7 H1FX JMJD4 LOXL1-AS1 LUZP1 MAP1LC3A MGP NCOA1 NUCKS1 P4HA2 PDLIM4 PIGU PSMB3 RAD9A RAPGEF6 RP11-250B2.6 RP11-474G23.2 RP11-73O6.3 RP13-39P12.3 SLC22A4 SLC38A2 SLC5A11 SLC9A3R2 SUFU TMEM176A TMEM180 TP53I3 YPEL3 ZBTB38 ZCCHC24
Arm fat-free mass (right)	8.38	52	44	97.8	0.93	1.2e-25	AC002550.5 AC034220.3 ADAM11 ADSL ARFGEF2 C10orf26 C18orf32 C2CD3 CADM2 CASKIN1 CD79B CDC42SE2 CEP250 CHMP1A CRIPAK CYP2D6 DCAF16 DLEU7 DOT1L DYM GDF5 GGT7 H1FX HMG20A LOXL1-AS1 LUZP1 MAP1LC3A MGP NCOA1 NUCKS1 P4HA2 PDLIM4 PIGU POLD3 PSMB3 RAD9A RAPGEF6 RP11-250B2.6 RP11-474G23.2 RP11-73O6.3 RP13-39P12.3 SLC22A4 SLC38A2 SLC5A11 SLC9A3R2 SUFU TMEM176A TMEM180 TP53I3 YPEL3 ZBTB38 ZCCHC24
Arm predicted mass (right)	8.25	51	45	100.0	0.93	2.6e-25	AC002550.5 AC034220.3 ADAM11 ADSL ARFGEF2 C10orf26 C18orf32 C2CD3 CADM2 CASKIN1 CD79B CDC42SE2 CEP250 CRIPAK CYP2D6 DCAF16 DLEU7 DOT1L DYM GDF5 GGT7 H1FX HMG20A LOXL1-AS1 LUZP1 MAP1LC3A MGP NCOA1 NUCKS1 P4HA2 PDLIM4 PIGU POLD3 PSMB3 RAD9A RAPGEF6 RP11-250B2.6 RP11-474G23.2 RP11-73O6.3 RP13-39P12.3 SLC22A4 SLC38A2 SLC5A11 SLC9A3R2 SUFU TMEM176A TMEM180 TP53I3 YPEL3 ZBTB38 ZCCHC24
Arm predicted mass (left)	8.14	50	43	95.6	0.93	7.0e-25	AC002550.5 AC034220.3 ADAM11 ADSL ARFGEF2 C10orf26 C18orf32 CADM2 CASKIN1 CD79B CDC42SE2 CEP250 CHMP1A CRIPAK CYP2D6 DCAF16 DLEU7 DOT1L DYM GDF5 GGT7 H1FX LOXL1-AS1 LUZP1 MAP1LC3A MGP NCOA1 NUCKS1 P4HA2 PDLIM4 PIGU POLD3 PSMB3 RAD9A RAPGEF6 RP11-250B2.6 RP11-474G23.2 RP11-73O6.3 RP13-39P12.3 SLC22A4 SLC38A2 SLC5A11 SLC9A3R2 SUFU TMEM176A TMEM180 TP53I3 YPEL3 ZBTB38 ZCCHC24
Arm fat-free mass (left)	8.07	49	44	97.8	0.94	5.8e-25	AC002550.5 AC034220.3 ADAM11 ADSL ARFGEF2 C10orf26 C18orf32 C2CD3 CADM2 CASKIN1 CD79B CDC42SE2 CEP250 CRIPAK CYP2D6 DCAF16 DLEU7 DOT1L DYM GDF5 GGT7 H1FX LOXL1-AS1 LUZP1 MAP1LC3A MGP NCOA1 NUCKS1 P4HA2 PDLIM4 PIGU PSMB3 RAD9A RAPGEF6 RP11-250B2.6 RP11-474G23.2 RP11-73O6.3 RP13-39P12.3 SLC22A4 SLC38A2 SLC5A11 SLC9A3R2 SUFU TMEM176A TMEM180 TP53I3 YPEL3 ZBTB38 ZCCHC24
Basal metabolic rate	7.97	50	43	95.6	0.93	1.9e-24	AC002550.5 AC034220.3 ADAM11 ADSL ARFGEF2 C10orf26 C18orf32 CADM2 CASKIN1 CD79B CDC42SE2 CEP250 CRIPAK CYP2D6 DCAF16 DLEU7 DOT1L DYM FZD2 GDF5 GGT7 H1FX JMJD4 LOXL1-AS1 LUZP1 MAP1LC3A MGP NCOA1 NUCKS1 P4HA2 PDLIM4 PIGU PSMB3 RAD9A RAPGEF6 RP11-250B2.6 RP11-474G23.2 RP11-73O6.3 RP13-39P12.3 SLC22A4 SLC38A2 SLC5A11 SLC9A3R2 SUFU TMEM176A TMEM180 TP53I3 YPEL3 ZBTB38 ZCCHC24
Forced vital capacity (FVC)	7.52	40	26	57.8	0.94	8.2e-23	ADAM11 ADCY3 AQP11 ARFGEF2 C16orf71 CCS CD79B CEP250 CHMP1A DCAF16 DNAJC27 DYM FNBP4 FZD2 GDF5 GGT7 H1FX JAG1 JMJD4 LOC100129961 LOXL1-AS1 NCOA1 NOB1 PML PSMB3 RAD9A RP11-250B2.6 RP11-443B20.1 RP11-474G23.2 RP11-73O6.3 RP13-39P12.3 SLC38A2 SUFU TMEM176A TMEM180 TP53I3 WNT3 ZBTB38 ZCCHC24 ZNF573
Leg fat-free mass (right)	7.25	48	39	86.7	0.91	1.4e-19	AC002550.5 AC034220.3 ADAM11 ADSL ARFGEF2 C10orf26 C18orf32 CADM2 CASKIN1 CD79B CDC42SE2 CEP250 CRIPAK DCAF16 DLEU7 DOT1L DYM FNBP4 FZD2 GDF5 GGT7 H1FX LOXL1-AS1 LUZP1 MAP1LC3A MGP NCOA1 NUCKS1 P4HA2 PDLIM4 PSMB3 RAD9A RAPGEF6 RP11-250B2.6 RP11-474G23.2 RP11-73O6.3 RP13-39P12.3 SLC22A4 SLC38A2 SLC5A11 SLC9A3R2 SUFU TMEM176A TMEM180 TP53I3 YPEL3 ZBTB38 ZCCHC24
Leg predicted mass (right)	7.25	48	39	86.7	0.91	5.0e-20	AC002550.5 AC034220.3 ADAM11 ADSL ARFGEF2 C10orf26 C18orf32 CADM2 CASKIN1 CD79B CDC42SE2 CEP250 CRIPAK DCAF16 DLEU7 DOT1L DYM FNBP4 FZD2 GDF5 GGT7 H1FX LOXL1-AS1 LUZP1 MAP1LC3A MGP NCOA1 NUCKS1 P4HA2 PDLIM4 PSMB3 RAD9A RAPGEF6 RP11-250B2.6 RP11-474G23.2 RP11-73O6.3 RP13-39P12.3 SLC22A4 SLC38A2 SLC5A11 SLC9A3R2 SUFU TMEM176A TMEM180 TP53I3 YPEL3 ZBTB38 ZCCHC24
Forced expiratory volume in 1-second (FEV1), predicted	7.23	25	16	35.6	0.96	4.8e-17	AC034220.3 ADCY3 C10orf26 CASKIN1 CD79B CEP250 DCAF16 DNAJC27 DOT1L DYM GDF5 GGT7 H1FX LOXL1-AS1 P4HA2 PDLIM4 RAD9A RP11-443B20.1 RP11-73O6.3 SLC22A4 SUFU TMEM180 TP53I3 ZBTB38 ZCCHC24
Leg fat-free mass (left)	7.14	46	39	86.7	0.92	1.5e-20	AC002550.5 AC034220.3 ADAM11 ADSL C10orf26 C18orf32 CADM2 CASKIN1 CD79B CDC42SE2 CEP250 CRIPAK DCAF16 DLEU7 DOT1L DYM FNBP4 FZD2 GDF5 GGT7 H1FX LOXL1-AS1 LUZP1 MAP1LC3A NCOA1 NUCKS1 P4HA2 PDLIM4 PSMB3 RAD9A RAPGEF6 RP11-250B2.6 RP11-474G23.2 RP11-73O6.3 RP13-39P12.3 SLC22A4 SLC38A2 SLC5A11 SLC9A3R2 SUFU TMEM176A TMEM180 TP53I3 YPEL3 ZBTB38 ZCCHC24
Leg predicted mass (left)	7.13	47	38	84.4	0.91	1.7e-19	AC002550.5 AC034220.3 ADAM11 ADSL C10orf26 C18orf32 CADM2 CASKIN1 CD79B CDC42SE2 CEP250 CRIPAK DCAF16 DLEU7 DOT1L DYM FNBP4 FZD2 GDF5 GGT7 H1FX LOXL1-AS1 LUZP1 MAP1LC3A MGP NCOA1 NUCKS1 P4HA2 PDLIM4 PSMB3 RAD9A RAPGEF6 RP11-250B2.6 RP11-474G23.2 RP11-73O6.3 RP13-39P12.3 SLC22A4 SLC38A2 SLC5A11 SLC9A3R2 SUFU TMEM176A TMEM180 TP53I3 YPEL3 ZBTB38 ZCCHC24
Forced vital capacity (FVC), Best measure	7.12	36	23	51.1	0.95	1.3e-21	ADAM11 ADCY3 ARFGEF2 C16orf71 CCS CD79B CEP250 CHMP1A DCAF16 DNAJC27 DYM FNBP4 FZD2 GDF5 GGT7 H1FX JAG1 LOC100129961 LOXL1-AS1 NCOA1 NOB1 PML PSMB3 RAD9A RFT1 RP11-250B2.6 RP11-443B20.1 RP11-474G23.2 RP11-73O6.3 RP13-39P12.3 SLC38A2 TMEM176A TP53I3 WNT3 ZBTB38 ZCCHC24
Forced expiratory volume in 1-second (FEV1)	6.25	33	20	44.4	0.95	1.2e-20	ADCY3 AQP11 ARFGEF2 C16orf71 CCS CD79B CEP250 CHMP1A DCAF16 DNAJC27 FZD2 GDF5 GGT7 GOLGA1 H1FX JAG1 LOC100129961 LOXL1-AS1 NOB1 P4HA2 PDLIM4 RAD9A RP11-250B2.6 RP11-443B20.1 RP11-73O6.3 RP13-39P12.3 SLC22A4 SLC38A2 TMEM176A TP53I3 WNT3 ZBTB38 ZCCHC24
Forced expiratory volume in 1-second (FEV1), Best measure	5.78	28	17	37.8	0.96	1.2e-18	ADAM11 ADCY3 ARFGEF2 C16orf71 CCS CD79B DCAF16 DNAJC27 FZD2 GDF5 GGT7 H1FX JAG1 LOC100129961 LOXL1-AS1 NOB1 PDLIM4 RAD9A RP11-250B2.6 RP11-443B20.1 RP11-73O6.3 RP13-39P12.3 SLC22A4 SLC38A2 TMEM176A WNT3 ZBTB38 ZCCHC24
Weight	5.73	37	29	64.4	0.67	1.4e-06	AC002550.5 AC034220.3 ADCY3 ADSL C10orf26 C18orf32 CADM2 CASKIN1 CD79B CEP250 CRIPAK DCAF16 DNAJC27 DOT1L FNBP4 FZD2 GDF5 GGT7 H1FX LUZP1 MAP1LC3A NUCKS1 P4HA2 PDLIM4 RAD9A RAPGEF6 RP11-443B20.1 RP11-73O6.3 SLC22A4 SLC38A2 SLC5A11 SLC9A3R2 SUFU TMEM180 YPEL3 ZBTB38 ZCCHC24
Peak expiratory flow (PEF)	5.50	23	9	20.0	0.92	5.6e-12	AQP11 CCS CD79B CEP250 CHMP1A DCAF16 GDF5 GGT7 H1FX HOXB2 LOXL1-AS1 MAP1LC3A NUCKS1 PIGU PML RAD9A SLC9A3R2 SUFU TMEM106C TMEM180 TP53I3 WNT3 ZNF573
Arm fat percentage (left)	5.09	14	11	24.4	-0.75	3.5e-04	ADCY3 ARFGEF2 CCS CD79B DCAF16 DNAJC27 EDEM3 FNBP4 FZD2 LOC100129961 NOB1 RP11-443B20.1 SLC5A11 YPEL3
Arm fat percentage (right)	5.08	14	11	24.4	-0.75	3.5e-04	ADCY3 ARFGEF2 CCS CD79B DCAF16 DNAJC27 EDEM3 FNBP4 FZD2 LOC100129961 NOB1 RP11-443B20.1 SLC5A11 YPEL3
BMI	4.96	23	16	35.6	-0.44	1.9e-02	AC002550.5 ADCY3 ADSL ARFGEF2 CADM2 CASKIN1 CCS DNAJC27 DYM EDEM3 FNBP4 FRAT1 LOC100129961 LOXL1-AS1 NCOA1 NOB1 PML RFT1 RP11-443B20.1 RP11-73O6.3 SLC5A11 SLC9A3R2 YPEL3
Leg fat percentage (left)	4.67	17	14	31.1	-0.66	1.7e-03	ADCY3 ARFGEF2 CADM2 CD79B CEP250 DCAF16 DNAJC27 EDEM3 FNBP4 GDF5 LOC100129961 NOB1 PML RP11-443B20.1 SLC5A11 SLC9A3R2 YPEL3
Leg fat percentage (right)	4.56	16	12	26.7	-0.67	1.9e-03	ADCY3 ARFGEF2 CADM2 CD79B CEP250 DCAF16 DNAJC27 EDEM3 FNBP4 GDF5 LOC100129961 NOB1 RP11-443B20.1 SLC5A11 SLC9A3R2 YPEL3
Heel T-Score	4.55	31	24	53.3	-0.02	9.1e-01	AC002550.5 ADSL C7orf58 CASKIN1 CHMP1A CRIPAK CYP2D6 DCAF16 DOT1L FZD2 GGT7 H1FX JAG1 JMJD4 KIF1B MAP1LC3A MGP PIGU PILRA PSMB3 RFT1 RP11-73O6.3 SLC38A2 SLC5A11 SLC9A3R2 TMEM106C WNT3 YLPM1 YPEL3 ZBTB38 ZCCHC24
Body mass index (BMI)	4.53	17	11	24.4	-0.54	1.1e-02	AC002550.5 ADCY3 ADSL ARFGEF2 CADM2 CCS DNAJC27 EDEM3 FNBP4 LOC100129961 LOXL1-AS1 NOB1 RFT1 RP11-443B20.1 SLC5A11 SLC9A3R2 YPEL3
Hip circumference	4.38	24	18	40.0	0.29	1.3e-01	ADCY3 CADM2 CASKIN1 CD79B CEP250 DCAF16 DNAJC27 DOT1L FNBP4 GDF5 GGT7 H1FX LOC100129961 LUZP1 MAP1LC3A NOB1 RAD9A RP11-443B20.1 RP11-73O6.3 SLC38A2 SLC5A11 SLC9A3R2 YPEL3 ZBTB38
Arm fat mass (left)	4.27	22	13	28.9	-0.08	7.1e-01	AC002550.5 ADCY3 ADSL CADM2 CASKIN1 CCS CEP250 DNAJC27 EDEM3 FNBP4 FZD2 GDF5 GGT7 LOC100129961 NOB1 RAD9A RP11-443B20.1 RP11-73O6.3 SLC5A11 SLC9A3R2 YPEL3 ZBTB38
Body fat percentage	4.24	16	10	22.2	-0.58	8.6e-03	ADCY3 ARFGEF2 CD79B DCAF16 DNAJC27 EDEM3 FNBP4 FZD2 LOC100129961 NOB1 NPC2 RP11-443B20.1 SLC5A11 SLC9A3R2 YPEL3 ZBTB38
Arm fat mass (right)	4.21	20	13	28.9	-0.14	5.3e-01	AC002550.5 ADCY3 ADSL CADM2 CASKIN1 CCS DNAJC27 EDEM3 FNBP4 FZD2 GDF5 GGT7 LOC100129961 NOB1 RP11-443B20.1 RP11-73O6.3 SLC5A11 SLC9A3R2 YPEL3 ZBTB38
Trunk fat mass	4.19	23	19	42.2	0.18	3.7e-01	ADCY3 C16orf71 CADM2 CASKIN1 CEP250 DNAJC27 EDEM3 FNBP4 FZD2 GDF5 GGT7 H1FX LOC100129961 NOB1 NPC2 RAD9A RP11-443B20.1 RP11-73O6.3 SLC5A11 SLC9A3R2 WNT3 YPEL3 ZBTB38
Whole body fat mass	4.15	21	17	37.8	0.06	7.7e-01	ADCY3 CADM2 CASKIN1 CEP250 DNAJC27 EDEM3 FNBP4 FZD2 GDF5 GGT7 H1FX LOC100129961 NOB1 NPC2 RAD9A RP11-443B20.1 RP11-73O6.3 SLC5A11 SLC9A3R2 YPEL3 ZBTB38
Leg fat mass (left)	4.12	17	14	31.1	-0.16	5.0e-01	ADCY3 ADSL CADM2 CASKIN1 DNAJC27 EDEM3 FNBP4 GGT7 LOC100129961 NOB1 RAD9A RP11-443B20.1 RP11-73O6.3 SLC5A11 SLC9A3R2 YPEL3 ZBTB38
Blood Eosinophil Count	4.10	13	10	22.2	-0.62	1.8e-02	AC034220.3 ADCY3 LUZP1 NOB1 P4HA2 PDLIM4 RAPGEF6 RFT1 RP11-443B20.1 RP11-73O6.3 SLC22A4 WNT3 YPEL3
Hair Pigment	4.07	17	13	28.9	-0.23	3.0e-01	ADCY3 CEP250 CHMP1A CORT DNAJC27 GDF5 GGT7 KIF1B LOC100129961 MAP1LC3A NUCKS1 PIGU RP11-443B20.1 RP11-73O6.3 SLC38A2 WNT3 ZBTB38
Leg fat mass (right)	4.05	17	13	28.9	-0.17	4.9e-01	ADCY3 ADSL CADM2 CASKIN1 DNAJC27 EDEM3 FNBP4 GGT7 LOC100129961 NOB1 RAD9A RP11-443B20.1 RP11-73O6.3 SLC5A11 SLC9A3R2 YPEL3 ZBTB38
Waist circumference	3.83	17	12	26.7	-0.03	9.1e-01	ADCY3 ADSL CADM2 CASKIN1 CRIPAK DNAJC27 EDEM3 FNBP4 GGT7 HOXB2 NOB1 RAD9A RP11-443B20.1 SLC5A11 SLC9A3R2 YPEL3 ZBTB38
Trunk fat percentage	3.81	19	13	28.9	-0.32	1.5e-01	ADCY3 ARFGEF2 CASKIN1 DNAJC27 EDEM3 FNBP4 FZD2 GGT7 KIF1B LOC100129961 NOB1 NPC2 RAD9A RP11-443B20.1 SLC5A11 SLC9A3R2 WNT3 YPEL3 ZBTB38
Crohns Disease (2017)	3.62	10	7	15.6	0.25	4.0e-01	AC034220.3 ADCY3 DNAJC27 P4HA2 PDLIM4 RAPGEF6 RFT1 RP11-443B20.1 SLC22A4 ZBTB38
Lung FVC	3.46	29	17	37.8	0.26	1.8e-01	ADAM11 ADAMTSL4 ARFGEF2 C16orf71 CD79B CEP250 CORT DCAF16 DOT1L FZD2 GDF5 HOXB2 JAG1 LOC100129961 LOXL1-AS1 MAP1LC3A NOB1 NPC2 NUCKS1 P4HA2 RAD9A RP11-73O6.3 SLC22A4 SLC38A2 TCF4 TMEM106C TMEM176A WNT3 ZBTB38
Impedance of leg (right)	3.44	26	20	44.4	-0.15	4.4e-01	AC002550.5 ADAM11 ADCY3 ADSL CADM2 CCS CD79B CDC42SE2 CEP250 CHMP1A DLEU7 DNAJC27 FNBP4 GDF5 H1FX LOXL1-AS1 NUCKS1 RAD9A RAPGEF6 RFT1 RP11-443B20.1 RP11-73O6.3 SLC38A2 TMEM106C TMEM176A YPEL3
Impedance of leg (left)	3.37	26	19	42.2	-0.12	5.1e-01	AC002550.5 ADAM11 ADCY3 ADSL CADM2 CCS CD79B CDC42SE2 CEP250 CHMP1A DLEU7 DNAJC27 FNBP4 GDF5 LOXL1-AS1 NUCKS1 RAD9A RAPGEF6 RFT1 RP11-443B20.1 RP11-73O6.3 SLC38A2 TMEM106C TMEM176A WNT3 YPEL3
Impedance of whole body	3.22	26	17	37.8	-0.26	1.7e-01	AC002550.5 ADCY3 ADSL CADM2 CCS CD79B CEP250 CORT DLEU7 DNAJC27 GDF5 KIF1B LOXL1-AS1 LUZP1 MAP1LC3A NUCKS1 RAD9A RAPGEF6 RFT1 RP11-443B20.1 RP11-73O6.3 SLC38A2 TMEM106C TMEM176A WNT3 YPEL3
Past tobacco smoking	3.17	6	3	6.7	-0.60	1.5e-01	C10orf26 CADM2 MAP1LC3A NOB1 SUFU TMEM180
Irritable Bowel Disease (IBD)	3.10	10	6	13.3	-0.07	8.3e-01	AC034220.3 ADAMTSL4 ADCY3 DNAJC27 NCOA1 P4HA2 PDLIM4 RAPGEF6 RP11-443B20.1 SLC22A4
Tanning	3.07	11	10	22.2	0.56	2.9e-02	ADAMTSL4 ADCY3 CADM2 CEP250 CHMP1A DNAJC27 GDF5 GGT7 MAP1LC3A PIGU RP11-443B20.1
Breast Cancer	3.04	11	9	20.0	-0.50	8.5e-02	ADCY3 ADSL CORT DNAJC27 P4HA2 PDLIM4 RP11-443B20.1 RP11-73O6.3 SLC22A4 WNT3 ZBTB38
Impedance of arm (left)	2.97	19	13	28.9	-0.47	3.8e-02	AC002550.5 ADSL CADM2 CD79B CORT FPR1 KIF1B LOXL1-AS1 MAP1LC3A NEB RAD9A RFT1 RP11-73O6.3 SLC38A2 SLC9A3R2 TMEM106C TMEM176A WNT3 YPEL3
Crohns Disease (2012)	2.90	5	2	4.4	0.75	1.5e-01	AC034220.3 ADCY3 P4HA2 PDLIM4 SLC22A4
Impedance of arm (right)	2.88	21	14	31.1	-0.56	6.8e-03	AC002550.5 ADSL CADM2 CD79B CEP250 CORT FPR1 KIF1B LOXL1-AS1 MAP1LC3A NEB NUCKS1 RFT1 RP11-474G23.2 RP11-73O6.3 SLC38A2 SLC9A3R2 TMEM106C TMEM176A WNT3 YPEL3
Asthma	2.85	8	4	8.9	-0.80	9.3e-03	AC034220.3 CCS CORT HOXB2 KIF1B P4HA2 PDLIM4 SLC22A4
Hair/balding pattern: Pattern 4	2.83	7	2	4.4	0.34	4.1e-01	CORT GGT7 MAP1LC3A PIGU RP13-39P12.3 WNT3 ZBTB38
Asthma (self-reported)	2.81	8	4	8.9	-0.80	9.4e-03	AC034220.3 CCS CORT HOXB2 KIF1B P4HA2 PDLIM4 SLC22A4
Heel bone mineral density (BMD) T-score, automated (left)	2.77	4	3	6.7	0.19	8.1e-01	C7orf58 CRIPAK FZD2 JAG1
Blood White Count	2.73	25	19	42.2	-0.48	1.3e-02	AC034220.3 ADAMTSL4 ADCY3 C10orf26 CASKIN1 CORT DCAF16 EDEM3 FRAT1 GGT7 MAP1LC3A NOB1 P4HA2 PDLIM4 PILRA RAPGEF6 RP11-73O6.3 RP13-39P12.3 SLC22A4 SLC5A11 SLC9A3R2 SUFU TMEM180 TP53I3 YPEL3
Heel bone mineral density (BMD) T-score, automated (right)	2.72	5	2	4.4	-0.37	5.4e-01	C7orf58 CRIPAK DCAF16 FZD2 ZBTB38
Body Mass Index (BMI) (2010)	2.69	5	3	6.7	-0.75	5.2e-02	AC002550.5 ADCY3 DNAJC27 FNBP4 RP11-443B20.1
Worrier / anxious feelings	2.69	7	6	13.3	-0.76	3.0e-02	C10orf26 CADM2 SUFU TCF4 TMEM180 WNT3 YLPM1
Blood Red Count	2.61	20	17	37.8	-0.25	2.4e-01	ADSL CCS CD79B DOT1L HOXB2 KIF1B LOC100129961 MAP1LC3A NOB1 PIGU PILRA RAD9A RP11-73O6.3 SLC9A3R2 TMEM106C TMEM176A TP53I3 WNT3 YPEL3 ZBTB38
Allergy	2.59	10	6	13.3	0.81	2.5e-03	AC034220.3 C10orf26 CORT KIF1B P4HA2 PDLIM4 SLC22A4 SUFU TMEM180 ZBTB38
Systolic Blood Pressure	2.58	17	15	33.3	0.26	2.7e-01	ADAM11 ADCY3 ARFGEF2 C16orf71 CADM2 CEP250 DCAF16 DNAJC27 FNBP4 GDF5 LOC100129961 RP11-443B20.1 RP11-474G23.2 RP1-257A7.5 SLC5A11 SLC9A3R2 TMEM106C
Smoking status: Previous	2.56	2	1	2.2	0.00	1.0e+00	CADM2 SUFU
Smoking Status	2.55	7	4	8.9	0.72	4.4e-02	C10orf26 CADM2 NOB1 SLC5A11 SUFU TMEM180 WNT3
Waist Hip Ratio (WHR)	2.48	18	12	26.7	-0.37	1.2e-01	ADCY3 C10orf26 C7orf58 CD79B CEP250 DOT1L DYM GDF5 H1FX JMJD4 POLD3 PSMB3 RAD9A RP11-250B2.6 RP11-443B20.1 RP11-73O6.3 WNT3 ZBTB38
Worry (Nagel 2018)	2.43	6	3	6.7	-0.41	4.2e-01	CADM2 FNBP4 TMEM180 WNT3 YLPM1 YPEL3
Respiratory disease	2.42	7	3	6.7	-0.79	3.6e-02	AC034220.3 CCS CORT HOXB2 P4HA2 PDLIM4 SLC22A4
Allergy or Eczema	2.39	7	4	8.9	-0.71	4.9e-02	C10orf26 LUZP1 P4HA2 SLC22A4 SUFU TMEM180 ZBTB38
Lung FEV1/FVC ratio	2.38	21	15	33.3	-0.09	6.6e-01	AC034220.3 ADCY3 ARFGEF2 DNAJC27 GDF5 GGT7 HOXB2 LOXL1-AS1 MAP1LC3A NCOA1 NEB NUCKS1 P4HA2 PDLIM4 PIGU PSMB3 RP11-443B20.1 SLC22A4 YLPM1 YPEL3 ZBTB38
Neuroticism	2.37	5	4	8.9	-0.28	6.5e-01	CADM2 FNBP4 TCF4 WNT3 YLPM1
Frequency of tiredness / lethargy in last 2 weeks	2.37	1	0	0.0	0.00	1.0e+00	POLD3
Ever smoked	2.37	3	2	4.4	0.00	1.0e+00	CADM2 SUFU TMEM180
Birth weight	2.32	4	1	2.2	0.49	5.1e-01	DCAF16 LUZP1 RFT1 RP11-73O6.3
Number of incorrect matches in round	2.29	3	2	4.4	0.00	1.0e+00	C10orf76 LOC100129961 YPEL3
Prostate Cancer	2.22	3	0	0.0	-0.44	5.6e-01	NUCKS1 SUFU TMEM180
Hayfever, allergic rhinitis or eczema	2.22	6	6	13.3	-0.72	6.8e-02	C10orf26 P4HA2 SLC22A4 SUFU TMEM180 ZBTB38
Neuroticism (Nagel 2018)	2.21	4	4	8.9	-0.13	8.7e-01	FNBP4 TCF4 WNT3 YLPM1
Hair/balding pattern: Pattern 3	2.20	2	1	2.2	0.00	1.0e+00	MAP1LC3A WNT3
Neuroticism score	2.19	4	4	8.9	-0.12	8.8e-01	FNBP4 TCF4 WNT3 YLPM1
Relative age of first facial hair	2.16	3	1	2.2	0.00	1.0e+00	CHMP1A WNT3 ZBTB38
Headache pain in last month	2.16	3	3	6.7	0.00	1.0e+00	ADAMTSL4 RP1-257A7.5 WNT3
Age when periods started (menarche)	2.14	7	3	6.7	0.64	4.7e-02	AC002550.5 ADCY3 DNAJC27 FNBP4 NOB1 RP11-443B20.1 YPEL3
Miserableness	2.14	4	3	6.7	-0.52	4.8e-01	FNBP4 LOXL1-AS1 TCF4 WNT3
Verbal and Numeric Reasoning (VNR)	2.11	7	4	8.9	-0.23	6.2e-01	ADCY3 ARFGEF2 C10orf76 CYP2D6 DCAF16 LRPPRC NPM3
Migraine (self-reported)	2.10	2	1	2.2	0.00	1.0e+00	ADAMTSL4 RP1-257A7.5
Osteoarthritis (self-reported)	2.09	1	1	2.2	0.00	1.0e+00	TGFA
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.08	4	3	6.7	0.75	2.5e-01	JAG1 NOB1 WNT3 YPEL3
Depressed Affect (Nagel 2018)	2.05	4	4	8.9	-0.16	8.4e-01	FNBP4 TCF4 WNT3 YLPM1
Systolic blood pressure, automated reading	2.05	11	4	8.9	-0.03	9.2e-01	ADCY3 C16orf71 DCAF16 EDEM3 FNBP4 LOC100129961 RP11-443B20.1 RP11-474G23.2 RP1-257A7.5 SLC5A11 SLC9A3R2
Nervous feelings	2.05	4	3	6.7	-0.68	3.2e-01	CADM2 WNT3 YLPM1 YPEL3
Reaction Time	2.04	4	0	0.0	0.09	8.8e-01	ADCY3 ARFGEF2 NUCKS1 TMEM180
Qualifications: College or University degree	2.04	10	5	11.1	0.02	9.6e-01	ARFGEF2 C10orf76 CADM2 CYP2D6 DCAF16 EDEM3 GDF5 NPM3 SLC5A11 WNT3
Mood swings	2.02	5	3	6.7	-0.33	5.9e-01	FNBP4 NUCKS1 TCF4 WNT3 YLPM1
Fractured/broken bones in last 5 years	2.01	3	1	2.2	0.00	1.0e+00	C7orf58 MGP WNT3
Blood Platelet Count	1.97	24	19	42.2	-0.40	4.3e-02	AC002550.5 AC034220.3 ADAM11 AQP11 C10orf26 DCAF16 DYM EDEM3 FNBP4 FZD2 HMG20A KIF1B P4HA2 PDLIM4 PIGU PILRA RAPGEF6 SLC22A4 SUFU TGFA TMEM106C TMEM180 YLPM1 ZCCHC24
Number of treatments/medications taken	1.97	4	0	0.0	-0.76	1.4e-01	CCS DCAF16 P4HA2 YLPM1
Knee pain experienced in last month	1.97	3	2	4.4	0.00	1.0e+00	CEP250 GDF5 TMEM106C
Birth weight of first child	1.93	3	1	2.2	0.00	1.0e+00	ARFGEF2 DCAF16 ZBTB38
Intelligence (Savage-Jansen 2018)	1.92	8	5	11.1	-0.06	8.9e-01	ARFGEF2 C10orf76 CYP2D6 DCAF16 LRPPRC NPC2 NPM3 WNT3
Overall health rating	1.92	3	1	2.2	-0.99	5.4e-03	CCS GOLGA1 TMEM106C
Ulcerative Colitis (UC)	1.91	1	0	0.0	0.00	1.0e+00	SLC22A4
Chronotype (morning person)	1.91	3	1	2.2	0.00	1.0e+00	ADAMTSL4 CRIPAK RP11-443B20.1
Medication for pain relief, constipation, heartburn	1.90	3	1	2.2	0.00	1.0e+00	FZD2 RP1-257A7.5 WNT3
Risk taking	1.88	1	1	2.2	0.00	1.0e+00	CADM2
Hearing difficulty/problems with background noise	1.87	1	1	2.2	0.00	1.0e+00	NUCKS1
Medication: Paracetamol	1.87	2	2	4.4	0.00	1.0e+00	RP1-257A7.5 WNT3
Angina (self-reported)	1.87	1	1	2.2	0.00	1.0e+00	RP1-257A7.5
Medication: Metformin	1.85	1	1	2.2	0.00	1.0e+00	FNBP4
Diastolic blood pressure, automated reading	1.85	8	4	8.9	0.03	9.4e-01	ADSL DCAF16 FNBP4 JAG1 LOC100129961 P4HA2 SLC5A11 SLC9A3R2
Fluid intelligence score	1.84	3	1	2.2	0.00	1.0e+00	C10orf76 DCAF16 NPM3
Illnesses of father: Heart disease	1.84	1	1	2.2	0.00	1.0e+00	RP1-257A7.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.83	2	2	4.4	0.00	1.0e+00	CCS TCF4
Mean time to correctly identify matches	1.82	3	1	2.2	0.00	1.0e+00	ARFGEF2 NUCKS1 RP11-73O6.3
Hypertension (Self-reported)	1.81	8	3	6.7	-0.83	1.1e-02	AC034220.3 C16orf71 DCAF16 EDEM3 P4HA2 PDLIM4 SLC22A4 SLC5A11
Medication: Paracetamol	1.80	2	1	2.2	0.00	1.0e+00	RP1-257A7.5 WNT3
Qualifications: A levels/AS levels or equivalent	1.79	6	0	0.0	0.17	7.5e-01	ARFGEF2 C10orf76 DCAF16 GDF5 NPM3 SLC5A11
Alcohol intake frequency.	1.77	7	4	8.9	-0.70	8.1e-02	CADM2 FNBP4 PILRA RP1-257A7.5 TCF4 WNT3 YPEL3
Suffer from 'nerves'	1.77	3	2	4.4	0.00	1.0e+00	CADM2 FNBP4 YLPM1
Number of self-reported non-cancer illnesses	1.77	2	0	0.0	0.00	1.0e+00	CCS SLC22A4
High blood pressure	1.76	9	2	4.4	-0.67	4.8e-02	AC034220.3 C16orf71 DCAF16 EDEM3 FNBP4 P4HA2 PDLIM4 SLC22A4 SLC5A11
Long-standing illness, disability or infirmity	1.75	1	0	0.0	0.00	1.0e+00	NOB1
Medication: Bendroflumethiazide	1.75	3	0	0.0	0.00	1.0e+00	AC034220.3 P4HA2 PDLIM4
Irritability	1.75	2	1	2.2	0.00	1.0e+00	TCF4 WNT3
Illnesses of siblings	1.73	1	0	0.0	0.00	1.0e+00	SLC5A11
Angina	1.71	1	1	2.2	0.00	1.0e+00	RP1-257A7.5
Medication: Blood pressure	1.71	3	1	2.2	0.00	1.0e+00	C16orf71 CHMP1A P4HA2
Vascular/heart problems diagnosed by doctor	1.70	8	3	6.7	0.80	1.7e-02	AC034220.3 C16orf71 DCAF16 EDEM3 P4HA2 PDLIM4 SLC22A4 SLC5A11
Coronary Artery Disease (CAD)	1.69	1	1	2.2	0.00	1.0e+00	RP1-257A7.5
Fed-up feelings	1.69	2	2	4.4	0.00	1.0e+00	WNT3 YLPM1
Mouth/teeth dental problems: Dentures	1.69	2	0	0.0	0.00	1.0e+00	ADCY3 PSMB3
Neuroticism (2016)	1.68	4	1	2.2	-0.04	9.6e-01	FNBP4 TCF4 WNT3 YLPM1
Sensitivity / hurt feelings	1.67	1	1	2.2	0.00	1.0e+00	WNT3
Maternal smoking around birth	1.67	2	0	0.0	0.00	1.0e+00	SLC5A11 TMEM180
Medication: Ibuprofen (e.g. Nurofen)	1.67	1	1	2.2	0.00	1.0e+00	RP1-257A7.5
Heart attack	1.66	1	1	2.2	0.00	1.0e+00	RP1-257A7.5
Smoking status: Current	1.66	2	0	0.0	0.00	1.0e+00	SUFU TMEM180
Loneliness, isolation	1.65	2	0	0.0	0.00	1.0e+00	ARFGEF2 WNT3
Guilty feelings	1.65	3	1	2.2	0.00	1.0e+00	FNBP4 WNT3 YLPM1
Current tobacco smoking	1.64	2	0	0.0	0.00	1.0e+00	SLC5A11 SUFU
Neck or shoulder pain in last month	1.64	1	0	0.0	0.00	1.0e+00	YPEL3
Supplements: Glucosamine	1.63	1	0	0.0	0.00	1.0e+00	MGP
Medication: Seretide 50 evohaler	1.63	3	0	0.0	0.00	1.0e+00	P4HA2 PDLIM4 SLC22A4
Diabetes diagnosed by doctor	1.63	1	0	0.0	0.00	1.0e+00	NOB1
Relative age voice broke	1.62	3	1	2.2	0.00	1.0e+00	CEP250 GDF5 WNT3
Heart disease (siblings)	1.62	1	1	2.2	0.00	1.0e+00	RP1-257A7.5
Tense / 'highly strung'	1.61	3	0	0.0	0.00	1.0e+00	CADM2 NUCKS1 YPEL3
Heart attack/myocardial infarction (self-reported)	1.58	1	1	2.2	0.00	1.0e+00	RP1-257A7.5
Medication: Blood pressure	1.57	1	0	0.0	0.00	1.0e+00	DCAF16
Type 2 Diabetes (T2D) (2018)	1.56	3	0	0.0	0.00	1.0e+00	C10orf26 FNBP4 NOB1
Qualifications: None of the above	1.56	4	3	6.7	0.50	5.0e-01	C10orf76 NPM3 RFT1 SLC5A11
Taking other prescription medications	1.55	1	0	0.0	0.00	1.0e+00	YLPM1
Multivitamins +/- minerals	1.55	1	0	0.0	0.00	1.0e+00	NUCKS1
Pulse rate, automated reading	1.54	5	1	2.2	-0.17	7.8e-01	ADCY3 C2CD3 CRIPAK LOC100129961 ZBTB38
Worry too long after embarrassment	1.53	1	0	0.0	0.00	1.0e+00	WNT3
Frequency of depressed mood in last 2 weeks	1.52	2	0	0.0	0.00	1.0e+00	ARFGEF2 WNT3
Number of children fathered	1.52	1	1	2.2	0.00	1.0e+00	CADM2
Ever had prostate specific antigen (PSA) test	1.51	1	0	0.0	0.00	1.0e+00	ZBTB38
Fasting Glucose	1.50	1	0	0.0	0.00	1.0e+00	FNBP4
High blood pressure (mother)	1.50	1	0	0.0	0.00	1.0e+00	TMEM106C
Pulse rate	1.50	2	1	2.2	0.00	1.0e+00	DLEU7 ZBTB38
Heart disease (mother)	1.49	1	0	0.0	0.00	1.0e+00	RP1-257A7.5
Mouth/teeth dental problems: Mouth ulcers	1.49	1	1	2.2	0.00	1.0e+00	WNT3
Diverticular disease/diverticulitis (self-reported)	1.48	1	0	0.0	0.00	1.0e+00	FZD2
HDL Cholesterol	1.47	1	0	0.0	0.00	1.0e+00	C18orf32
Frequency of tenseness / restlessness in last 2 weeks	1.47	1	1	2.2	0.00	1.0e+00	WNT3
Wheeze or whistling in the chest in last year	1.45	2	0	0.0	0.00	1.0e+00	GOLGA1 YPEL3
Major Depression (MDD)	1.40	1	0	0.0	0.00	1.0e+00	TCF4
Hair/balding pattern: Pattern 2	1.39	1	1	2.2	0.00	1.0e+00	WNT3
Mouth/teeth dental problems	1.38	1	0	0.0	0.00	1.0e+00	WNT3
Medication: Ibuprofen	1.37	1	1	2.2	0.00	1.0e+00	RP1-257A7.5
Handedness (chirality/laterality): Left-handed	1.37	1	1	2.2	0.00	1.0e+00	WNT3
Average weekly champagne plus white wine intake	1.36	1	0	0.0	0.00	1.0e+00	WNT3
Bipolar Disorder or Schizophrenia	1.34	2	0	0.0	0.00	1.0e+00	CCS YPEL3
Cardiovascular Disease	1.33	5	2	4.4	-0.99	8.7e-04	DCAF16 EDEM3 RP11-474G23.2 SLC22A4 TMEM106C
Depression (Nagel 2018)	1.31	1	0	0.0	0.00	1.0e+00	WNT3
Schizophrenia (2014)	1.31	1	0	0.0	0.00	1.0e+00	YPEL3
Average weekly fortified wine intake	1.26	1	0	0.0	0.00	1.0e+00	SLC5A11
Age at first live birth	1.26	2	0	0.0	0.00	1.0e+00	DCAF16 EDEM3
Ever unenthusiastic/disinterested for a whole week	1.25	1	0	0.0	0.00	1.0e+00	WNT3
Time employed in main current job	1.25	1	1	2.2	0.00	1.0e+00	WNT3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.25	1	0	0.0	0.00	1.0e+00	ADAMTSL4
Ovarian Cancer	1.18	2	1	2.2	0.00	1.0e+00	HOXB2 WNT3
Medication for cholesterol, blood pressure or diabetes	1.18	1	0	0.0	0.00	1.0e+00	TMEM106C
Medication for cholesterol	1.17	1	0	0.0	0.00	1.0e+00	C16orf71
Medication: Cholesterol lowering	1.16	1	0	0.0	0.00	1.0e+00	TMEM106C
Number of live births	1.15	2	1	2.2	0.00	1.0e+00	CADM2 WNT3
Primary Biliary Cirrhosis	1.14	1	0	0.0	0.00	1.0e+00	WNT3
Qualifications: O levels/GCSEs or equivalent	1.13	1	0	0.0	0.00	1.0e+00	C16orf71
Alzheimer’s Disease (including proxy)	1.10	1	0	0.0	0.00	1.0e+00	YPEL3
Number of full sisters	1.09	1	1	2.2	0.00	1.0e+00	CADM2
High cholesterol (Self-reported)	1.06	2	0	0.0	0.00	1.0e+00	DCAF16 TMEM106C
Had menopause	1.04	1	0	0.0	0.00	1.0e+00	RP11-73O6.3
Cholesterol lowering medication	1.02	1	0	0.0	0.00	1.0e+00	DCAF16
Leg pain on walking	0.86	1	0	0.0	0.00	1.0e+00	WNT3

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Uterus	11	1.94	3.2
GTEx	Brain Nucleus accumbens basal ganglia	16	1.85	3.1
GTEx	Pituitary	15	1.35	3.1
GTEx	Brain Cortex	22	2.13	3.0
GTEx	Brain Hippocampus	7	1.34	3.0
GTEx	Cells EBV-transformed lymphocytes	23	1.62	3.0
GTEx	Liver	10	1.39	3.0
GTEx	Ovary	17	1.87	3.0
GTEx	Spleen	19	1.35	3.0
GTEx	Artery Coronary	16	1.35	2.9
GTEx	Brain Cerebellar Hemisphere	17	1.14	2.9
GTEx	Brain Frontal Cortex BA9	16	1.73	2.9
GTEx	Brain Hypothalamus	7	1.19	2.9
GTEx	Brain Putamen basal ganglia	9	1.44	2.9
GTEx	Breast Mammary Tissue (Male)	19	1.59	2.9
GTEx	Prostate	13	1.56	2.9
GTEx	Small Intestine Terminal Ileum	7	1.52	2.9
GTEx	Vagina	9	1.42	2.9
The Cancer Genome Atlas	Esophageal Carcinoma	8	1.17	2.9
GTEx	Adipose Subcutaneous	39	1.12	2.8
GTEx	Adipose Visceral Omentum	18	0.88	2.8
GTEx	Artery Aorta	33	1.11	2.8
GTEx	Brain Caudate basal ganglia	12	1.30	2.8
GTEx	Brain Cerebellum	21	1.06	2.8
GTEx	Esophagus Gastroesophageal Junction	18	1.25	2.8
GTEx	Esophagus Mucosa	34	1.02	2.8
GTEx	Heart Atrial Appendage	16	1.01	2.8
GTEx	Lung	34	1.18	2.8
GTEx	Muscle Skeletal	37	1.28	2.8
GTEx	Skin Not Sun Exposed Suprapubic	27	1.10	2.8
GTEx	Skin Sun Exposed Lower leg	36	0.99	2.8
GTEx	Stomach	21	1.44	2.8
GTEx	Testis	39	1.24	2.8
GTEx	Whole Blood	25	1.25	2.8
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	5	0.98	2.8
GTEx	Adrenal Gland	18	1.24	2.7
GTEx	Artery Tibial	31	0.82	2.7
GTEx	Breast Mammary Tissue	24	1.22	2.7
GTEx	Colon Transverse	22	1.07	2.7
GTEx	Nerve Tibial	48	1.11	2.7
GTEx	Pancreas	16	0.98	2.7
GTEx	Thyroid	42	1.05	2.7
The Cancer Genome Atlas	Glioblastoma Multiforme	11	1.08	2.7
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	12	1.08	2.7
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	15	0.94	2.7
The Cancer Genome Atlas	Rectum Adenocarcinoma	8	1.16	2.7
The Cancer Genome Atlas	Skin Cutaneous Melanoma	6	1.12	2.7
GTEx	Breast Mammary Tissue (Female)	19	1.16	2.6
GTEx	Cells Transformed fibroblasts	37	0.88	2.6
GTEx	Colon Sigmoid	14	0.96	2.6
GTEx	Esophagus Muscularis	30	0.93	2.6
GTEx	Heart Left Ventricle	17	1.11	2.6
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	14	0.85	2.6
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	18	0.66	2.6
The Cancer Genome Atlas	Soft Tissue Sarcoma	7	0.66	2.6
NTR	Blood	18	0.75	2.5
ROSMAP	Brain Pre-frontal Cortex	32	0.73	2.5
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	8	0.73	2.5
The Cancer Genome Atlas	Colon Adenocarcinoma	15	0.73	2.5
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	23	0.56	2.5
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	12	0.59	2.5
The Cancer Genome Atlas	Brain Lower Grade Glioma	28	0.65	2.5
The Cancer Genome Atlas	Lung Adenocarcinoma	19	0.65	2.5
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	16	0.64	2.5
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	9	0.54	2.5
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	8	0.60	2.5
The Cancer Genome Atlas	Prostate Adenocarcinoma	30	0.65	2.5
The Cancer Genome Atlas	Stomach Adenocarcinoma	11	0.65	2.5
The Cancer Genome Atlas	Testicular Germ Cell Tumors	14	1.09	2.5
METSIM	Adipose	32	0.69	2.4
YFS	Blood	28	0.61	2.4
CommonMind	Brain Pre-frontal Cortex	32	0.60	2.4
The Cancer Genome Atlas	Breast Invasive Carcinoma	29	0.66	2.4
The Cancer Genome Atlas	Thyroid Carcinoma	34	0.66	2.4