TWAS
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Models
Genes
Traits
[Hub]/) :
Traits
:
Ever unenthusiastic/disinterested for a whole week
:
chr5:139,323,257-140,722,126
Best TWAS P=8.24e-08 · Best GWAS P=2.1e-06 conditioned to 0.777
139.4M
139.6M
139.8M
140M
140.2M
140.4M
140.6M
140.8M
0
1
2
3
4
5
6
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
ROSMAP
Brain Pre-frontal Cortex
ZMAT2
0.03
0.02
bslmm
185
0.02
6.5e-04
-4.2
-5.4
8.2e-08
0.86
0.04
0.90
TRUE
2
ROSMAP
Brain Pre-frontal Cortex
NDUFA2
0.09
0.12
enet
22
0.12
1.3e-15
-4.2
5.2
1.9e-07
-0.85
0.04
0.92
FALSE
1
CommonMind
Brain Pre-frontal Cortex
NDUFA2
0.02
0.01
bslmm
343
0.01
7.8e-03
-4.5
5.2
2.1e-07
-0.90
0.07
0.65
FALSE