Hub : Traits :

Ever unenthusiastic/disinterested for a whole week

4 significantly associated models · 3 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	5	139323257	140722126	2	1	8.2e-08	2.1e-06	0.78	100	ZMAT2

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Intelligence (Savage-Jansen 2018)	20.27	1	1	2.2	1	ZMAT2
Verbal and Numeric Reasoning (VNR)	15.71	1	1	2.2	1	ZMAT2
Friendships satisfaction	14.37	1	0	0.0	1	ZMAT2
Bipolar Disorder or Schizophrenia	10.89	1	1	2.2	1	ZMAT2
Systolic Blood Pressure	9.72	1	1	2.2	1	ZMAT2
Schizophrenia (2018)	9.71	1	0	0.0	1	ZMAT2
Bipolar Disorder (2011)	8.88	1	0	0.0	1	ZMAT2
Depression (Nagel 2018)	8.87	1	0	0.0	1	ZMAT2
Family relationship satisfaction	8.24	1	0	0.0	1	ZMAT2
Forced expiratory volume in 1-second (FEV1), predicted percentage	8.07	1	0	0.0	1	ZMAT2
Respiratory disease	8.04	1	0	0.0	1	ZMAT2
Fluid intelligence score	7.51	1	0	0.0	1	ZMAT2
Medication: Seretide 50 evohaler	7.17	1	0	0.0	1	ZMAT2
Lung FVC	7.08	1	1	2.2	1	ZMAT2
Neuroticism	7.04	1	0	0.0	1	ZMAT2
Ever depressed for a whole week	6.97	1	0	0.0	1	ZMAT2
Forced vital capacity (FVC), Best measure	6.81	1	0	0.0	1	ZMAT2
Forced expiratory volume in 1-second (FEV1), Best measure	6.78	1	0	0.0	1	ZMAT2
Asthma (self-reported)	6.69	1	0	0.0	1	ZMAT2
Financial situation satisfaction	6.59	1	0	0.0	1	ZMAT2
Ever smoked	6.17	1	0	0.0	1	ZMAT2
Mouth/teeth dental problems: Bleeding gums	6.15	1	0	0.0	1	ZMAT2
Eye problems/disorders: None of the above	5.95	1	0	0.0	1	ZMAT2
Asthma	5.85	1	0	0.0	1	ZMAT2
Depressed Affect (Nagel 2018)	5.63	1	0	0.0	1	ZMAT2
Miserableness	5.58	1	0	0.0	1	ZMAT2
Alzheimer’s Disease (including proxy)	5.37	1	0	0.0	1	ZMAT2
Mean time to correctly identify matches	5.35	1	0	0.0	1	ZMAT2
Chest pain or discomfort	5.32	1	0	0.0	1	ZMAT2
Reaction Time	5.26	1	0	0.0	1	ZMAT2
Schizophrenia (2014)	5.21	1	0	0.0	1	ZMAT2
Forced vital capacity (FVC)	5.19	1	0	0.0	1	ZMAT2
Frequency of depressed mood in last 2 weeks	5.03	1	0	0.0	1	ZMAT2
Hip circumference	5.00	1	0	0.0	1	ZMAT2
Qualifications: College or University degree	5.00	1	0	0.0	1	ZMAT2
Frequency of tiredness / lethargy in last 2 weeks	4.93	1	0	0.0	1	ZMAT2
Frequency of tenseness / restlessness in last 2 weeks	4.89	1	0	0.0	1	ZMAT2
Bipolar Disorder (2018)	4.58	1	0	0.0	1	ZMAT2
BMI	4.57	1	1	2.2	1	ZMAT2
Past tobacco smoking	4.39	1	0	0.0	1	ZMAT2
Neuroticism score	4.37	1	0	0.0	1	ZMAT2
Weight	4.36	1	0	0.0	1	ZMAT2
Qualifications: None of the above	4.35	1	0	0.0	1	ZMAT2
Worry too long after embarrassment	4.33	1	0	0.0	1	ZMAT2
Neuroticism (Nagel 2018)	4.27	1	0	0.0	1	ZMAT2
Arm fat mass (left)	4.19	1	0	0.0	1	ZMAT2
Arm fat mass (right)	4.16	1	0	0.0	1	ZMAT2
Medication: Bendroflumethiazide	4.12	1	0	0.0	1	ZMAT2
Basal metabolic rate	4.06	1	0	0.0	1	ZMAT2
Arm predicted mass (left)	3.93	1	0	0.0	1	ZMAT2
Forced expiratory volume in 1-second (FEV1)	3.92	1	0	0.0	1	ZMAT2
Allergy	3.86	1	0	0.0	1	ZMAT2
Arm fat-free mass (right)	3.79	1	0	0.0	1	ZMAT2
Arm predicted mass (right)	3.77	1	0	0.0	1	ZMAT2
Whole body water mass	3.71	1	0	0.0	1	ZMAT2
Birth weight	3.61	1	0	0.0	1	ZMAT2
Body mass index (BMI)	3.57	1	0	0.0	1	ZMAT2
Whole body fat-free mass	3.57	1	0	0.0	1	ZMAT2
Leg predicted mass (right)	3.56	1	0	0.0	1	ZMAT2
Arm fat-free mass (left)	3.53	1	0	0.0	1	ZMAT2
Leg predicted mass (left)	3.51	1	0	0.0	1	ZMAT2
Leg fat-free mass (right)	3.49	1	0	0.0	1	ZMAT2
Leg fat-free mass (left)	3.47	1	0	0.0	1	ZMAT2
Trunk fat-free mass	3.37	1	0	0.0	1	ZMAT2
Trunk predicted mass	3.34	1	0	0.0	1	ZMAT2
Trunk fat mass	3.33	1	0	0.0	1	ZMAT2
Whole body fat mass	3.02	1	0	0.0	1	ZMAT2
Impedance of whole body	2.90	1	0	0.0	1	ZMAT2
Waist circumference	2.88	1	0	0.0	1	ZMAT2
Leg fat mass (left)	2.81	1	0	0.0	1	ZMAT2
Age when periods started (menarche)	2.79	1	0	0.0	1	ZMAT2
Leg fat mass (right)	2.76	1	0	0.0	1	ZMAT2
Arm fat percentage (left)	2.75	1	0	0.0	1	ZMAT2
Allergy or Eczema	2.57	1	0	0.0	1	ZMAT2
Arm fat percentage (right)	2.49	1	0	0.0	1	ZMAT2
Trunk fat percentage	2.44	1	0	0.0	1	ZMAT2
Impedance of leg (right)	2.41	1	0	0.0	1	ZMAT2
Body fat percentage	2.36	1	0	0.0	1	ZMAT2
Impedance of leg (left)	2.28	1	0	0.0	1	ZMAT2
Waist Hip Ratio (WHR)	2.16	1	0	0.0	1	ZMAT2
Impedance of arm (right)	2.10	1	0	0.0	1	ZMAT2
Sitting height	1.86	1	0	0.0	1	ZMAT2
Impedance of arm (left)	1.47	1	0	0.0	1	ZMAT2
Blood White Count	1.33	1	0	0.0	1	ZMAT2
Height	0.47	1	0	0.0	1	ZMAT2

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Brain Frontal Cortex BA9	0	0.000	1.4
GTEx	Brain Hippocampus	0	0.000	1.4
GTEx	Brain Hypothalamus	0	0.000	1.4
GTEx	Heart Left Ventricle	0	0.000	1.4
GTEx	Small Intestine Terminal Ileum	0	0.000	1.4
GTEx	Adipose Visceral Omentum	0	0.000	1.3
GTEx	Artery Aorta	0	0.000	1.3
GTEx	Artery Coronary	0	0.000	1.3
GTEx	Brain Caudate basal ganglia	0	0.000	1.3
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.3
GTEx	Brain Cortex	0	0.000	1.3
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.3
GTEx	Brain Putamen basal ganglia	0	0.000	1.3
GTEx	Breast Mammary Tissue	0	0.000	1.3
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.3
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.3
GTEx	Colon Transverse	0	0.000	1.3
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.3
GTEx	Esophagus Mucosa	0	0.000	1.3
GTEx	Esophagus Muscularis	0	0.000	1.3
GTEx	Heart Atrial Appendage	0	0.000	1.3
GTEx	Lung	0	0.000	1.3
GTEx	Muscle Skeletal	0	0.000	1.3
GTEx	Ovary	0	0.000	1.3
GTEx	Pancreas	0	0.000	1.3
GTEx	Pituitary	0	0.000	1.3
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.3
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.3
GTEx	Spleen	0	0.000	1.3
GTEx	Stomach	0	0.000	1.3
GTEx	Thyroid	0	0.000	1.3
GTEx	Uterus	0	0.000	1.3
GTEx	Vagina	0	0.000	1.3
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.3
GTEx	Adipose Subcutaneous	0	0.000	1.2
GTEx	Adrenal Gland	0	0.000	1.2
GTEx	Artery Tibial	0	0.000	1.2
GTEx	Brain Cerebellum	0	0.000	1.2
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.2
GTEx	Cells Transformed fibroblasts	0	0.000	1.2
GTEx	Colon Sigmoid	0	0.000	1.2
GTEx	Liver	0	0.000	1.2
GTEx	Nerve Tibial	0	0.000	1.2
GTEx	Prostate	0	0.000	1.2
GTEx	Testis	0	0.000	1.2
METSIM	Adipose	0	0.000	1.2
NTR	Blood	0	0.000	1.2
ROSMAP	Brain Pre-frontal Cortex	2	0.046	1.2
CommonMind	Brain Pre-frontal Cortex	1	0.019	1.2
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.2
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.2
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.2
The Cancer Genome Atlas	Prostate Adenocarcinoma	1	0.022	1.2
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.2
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.2
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.2
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.2
GTEx	Whole Blood	0	0.000	1.1
YFS	Blood	0	0.000	1.1
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.1