Hub : Traits :

Ever unenthusiastic/disinterested for a whole week

4 significantly associated models · 3 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 5 139323257 140722126 2 1 8.2e-08 2.1e-06 0.78 100 ZMAT2

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder (2018) 4.58 1 0 0.0 0 1 ZMAT2
Bipolar Disorder or Schizophrenia 10.89 1 1 2.2 0 1 ZMAT2
Depressed Affect (Nagel 2018) 5.63 1 0 0.0 0 1 ZMAT2
Depression (Nagel 2018) 8.87 1 0 0.0 0 1 ZMAT2
Intelligence (Savage-Jansen 2018) 20.27 1 1 2.2 0 1 ZMAT2
Neuroticism (Nagel 2018) 4.27 1 0 0.0 0 1 ZMAT2
Schizophrenia (2018) 9.71 1 0 0.0 0 1 ZMAT2
Alzheimer’s Disease (including proxy) 5.37 1 0 0.0 0 1 ZMAT2
Reaction Time 5.26 1 0 0.0 0 1 ZMAT2
Verbal and Numeric Reasoning (VNR) 15.71 1 1 2.2 0 1 ZMAT2
Bipolar Disorder (2011) 8.88 1 0 0.0 0 1 ZMAT2
Schizophrenia (2014) 5.21 1 0 0.0 0 1 ZMAT2
Blood White Count 1.33 1 0 0.0 0 1 ZMAT2
BMI 4.57 1 1 2.2 0 1 ZMAT2
Height 0.47 1 0 0.0 0 1 ZMAT2
Waist Hip Ratio (WHR) 2.16 1 0 0.0 0 1 ZMAT2
Systolic Blood Pressure 9.72 1 1 2.2 0 1 ZMAT2
Allergy or Eczema 2.57 1 0 0.0 0 1 ZMAT2
Respiratory disease 8.04 1 0 0.0 0 1 ZMAT2
Lung FVC 7.08 1 1 2.2 0 1 ZMAT2
Neuroticism 7.04 1 0 0.0 0 1 ZMAT2
Frequency of depressed mood in last 2 weeks 5.03 1 0 0.0 0 1 ZMAT2
Impedance of leg (right) 2.41 1 0 0.0 0 1 ZMAT2
Leg fat-free mass (left) 3.47 1 0 0.0 0 1 ZMAT2
Trunk fat percentage 2.44 1 0 0.0 0 1 ZMAT2
Age when periods started (menarche) 2.79 1 0 0.0 0 1 ZMAT2
Sitting height 1.86 1 0 0.0 0 1 ZMAT2
Body mass index (BMI) 3.57 1 0 0.0 0 1 ZMAT2
Impedance of leg (left) 2.28 1 0 0.0 0 1 ZMAT2
Leg predicted mass (left) 3.51 1 0 0.0 0 1 ZMAT2
Trunk fat mass 3.33 1 0 0.0 0 1 ZMAT2
Waist circumference 2.88 1 0 0.0 0 1 ZMAT2
Past tobacco smoking 4.39 1 0 0.0 0 1 ZMAT2
Frequency of tenseness / restlessness in last 2 weeks 4.89 1 0 0.0 0 1 ZMAT2
Forced vital capacity (FVC) 5.19 1 0 0.0 0 1 ZMAT2
Qualifications: None of the above 4.35 1 0 0.0 0 1 ZMAT2
Allergy 3.86 1 0 0.0 0 1 ZMAT2
Fluid intelligence score 7.51 1 0 0.0 0 1 ZMAT2
Neuroticism score 4.37 1 0 0.0 0 1 ZMAT2
Weight 4.36 1 0 0.0 0 1 ZMAT2
Impedance of arm (right) 2.10 1 0 0.0 0 1 ZMAT2
Arm fat percentage (right) 2.49 1 0 0.0 0 1 ZMAT2
Trunk fat-free mass 3.37 1 0 0.0 0 1 ZMAT2
Hip circumference 5.00 1 0 0.0 0 1 ZMAT2
Frequency of tiredness / lethargy in last 2 weeks 4.93 1 0 0.0 0 1 ZMAT2
Forced expiratory volume in 1-second (FEV1) 3.92 1 0 0.0 0 1 ZMAT2
Asthma 5.85 1 0 0.0 0 1 ZMAT2
Forced expiratory volume in 1-second (FEV1), Best measure 6.78 1 0 0.0 0 1 ZMAT2
Impedance of arm (left) 1.47 1 0 0.0 0 1 ZMAT2
Arm fat mass (right) 4.16 1 0 0.0 0 1 ZMAT2
Trunk predicted mass 3.34 1 0 0.0 0 1 ZMAT2
Mouth/teeth dental problems: Bleeding gums 6.15 1 0 0.0 0 1 ZMAT2
Birth weight 3.61 1 0 0.0 0 1 ZMAT2
Forced vital capacity (FVC), Best measure 6.81 1 0 0.0 0 1 ZMAT2
Body fat percentage 2.36 1 0 0.0 0 1 ZMAT2
Arm fat-free mass (right) 3.79 1 0 0.0 0 1 ZMAT2
Worry too long after embarrassment 4.33 1 0 0.0 0 1 ZMAT2
Qualifications: College or University degree 5.00 1 0 0.0 0 1 ZMAT2
Eye problems/disorders: None of the above 5.95 1 0 0.0 0 1 ZMAT2
Medication: Seretide 50 evohaler 7.17 1 0 0.0 0 1 ZMAT2
Mean time to correctly identify matches 5.35 1 0 0.0 0 1 ZMAT2
Whole body fat mass 3.02 1 0 0.0 0 1 ZMAT2
Leg fat mass (right) 2.76 1 0 0.0 0 1 ZMAT2
Arm predicted mass (right) 3.77 1 0 0.0 0 1 ZMAT2
Chest pain or discomfort 5.32 1 0 0.0 0 1 ZMAT2
Family relationship satisfaction 8.24 1 0 0.0 0 1 ZMAT2
Whole body fat-free mass 3.57 1 0 0.0 0 1 ZMAT2
Leg fat-free mass (right) 3.49 1 0 0.0 0 1 ZMAT2
Arm fat percentage (left) 2.75 1 0 0.0 0 1 ZMAT2
Friendships satisfaction 14.37 1 0 0.0 0 1 ZMAT2
Asthma (self-reported) 6.69 1 0 0.0 0 1 ZMAT2
Forced expiratory volume in 1-second (FEV1), predicted percentage 8.07 1 0 0.0 0 1 ZMAT2
Whole body water mass 3.71 1 0 0.0 0 1 ZMAT2
Leg predicted mass (right) 3.56 1 0 0.0 0 1 ZMAT2
Arm fat mass (left) 4.19 1 0 0.0 0 1 ZMAT2
Miserableness 5.58 1 0 0.0 0 1 ZMAT2
Financial situation satisfaction 6.59 1 0 0.0 0 1 ZMAT2
Medication: Bendroflumethiazide 4.12 1 0 0.0 0 1 ZMAT2
Ever smoked 6.17 1 0 0.0 0 1 ZMAT2
Basal metabolic rate 4.06 1 0 0.0 0 1 ZMAT2
Arm fat-free mass (left) 3.53 1 0 0.0 0 1 ZMAT2
Ever depressed for a whole week 6.97 1 0 0.0 0 1 ZMAT2
Impedance of whole body 2.90 1 0 0.0 0 1 ZMAT2
Leg fat mass (left) 2.81 1 0 0.0 0 1 ZMAT2
Arm predicted mass (left) 3.93 1 0 0.0 0 1 ZMAT2

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.2
GTEx Adipose Visceral Omentum 0 0.000 1.3
GTEx Adrenal Gland 0 0.000 1.2
GTEx Artery Aorta 0 0.000 1.3
GTEx Artery Coronary 0 0.000 1.3
GTEx Artery Tibial 0 0.000 1.2
GTEx Brain Caudate basal ganglia 0 0.000 1.3
GTEx Brain Cerebellar Hemisphere 0 0.000 1.3
GTEx Brain Cerebellum 0 0.000 1.2
GTEx Brain Cortex 0 0.000 1.3
GTEx Brain Frontal Cortex BA9 0 0.000 1.4
GTEx Brain Hippocampus 0 0.000 1.4
GTEx Brain Hypothalamus 0 0.000 1.4
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.3
GTEx Brain Putamen basal ganglia 0 0.000 1.3
GTEx Breast Mammary Tissue 0 0.000 1.3
GTEx Breast Mammary Tissue (Male) 0 0.000 1.3
GTEx Breast Mammary Tissue (Female) 0 0.000 1.2
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.3
GTEx Cells Transformed fibroblasts 0 0.000 1.2
GTEx Colon Sigmoid 0 0.000 1.2
GTEx Colon Transverse 0 0.000 1.3
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.3
GTEx Esophagus Mucosa 0 0.000 1.3
GTEx Esophagus Muscularis 0 0.000 1.3
GTEx Heart Atrial Appendage 0 0.000 1.3
GTEx Heart Left Ventricle 0 0.000 1.4
GTEx Liver 0 0.000 1.2
GTEx Lung 0 0.000 1.3
GTEx Muscle Skeletal 0 0.000 1.3
GTEx Nerve Tibial 0 0.000 1.2
GTEx Ovary 0 0.000 1.3
GTEx Pancreas 0 0.000 1.3
GTEx Pituitary 0 0.000 1.3
GTEx Prostate 0 0.000 1.2
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.3
GTEx Skin Sun Exposed Lower leg 0 0.000 1.3
GTEx Small Intestine Terminal Ileum 0 0.000 1.4
GTEx Spleen 0 0.000 1.3
GTEx Stomach 0 0.000 1.3
GTEx Testis 0 0.000 1.2
GTEx Thyroid 0 0.000 1.3
GTEx Uterus 0 0.000 1.3
GTEx Vagina 0 0.000 1.3
GTEx Whole Blood 0 0.000 1.1
METSIM Adipose 0 0.000 1.2
NTR Blood 0 0.000 1.2
ROSMAP Brain Pre-frontal Cortex 2 0.046 1.2
YFS Blood 0 0.000 1.1
CommonMind Brain Pre-frontal Cortex 1 0.019 1.2
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.2
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.2
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.2
The Cancer Genome Atlas Prostate Adenocarcinoma 1 0.022 1.2
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.2
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.2
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.2
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.1