TWAS
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Models
Genes
Traits
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Traits
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Hand grip strength (right)
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chr18:12,304,781-13,822,256
Best TWAS P=3.27e-08 · Best GWAS P=7.97e-09 conditioned to 7.73e-05
12.4M
12.6M
12.8M
13M
13.2M
13.4M
13.6M
13.8M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Cells EBV-transformed lymphocytes
CEP192
0.52
0.34
lasso
5
0.36
1.6e-12
4.6
5.5
3.3e-08
0.38
0.27
0.71
TRUE
1
GTEx
Breast Mammary Tissue (Female)
CEP192
0.34
0.23
lasso
11
0.26
2.4e-08
4.8
5.3
1.5e-07
0.17
0.21
0.77
FALSE
3
GTEx
Liver
CEP192
0.41
0.29
lasso
6
0.41
1.6e-12
4.8
5.2
2.3e-07
0.17
0.19
0.80
FALSE
4
The Cancer Genome Atlas
Ovarian Serous Cystadenocarcinoma
CEP192
0.09
0.07
blup
84
0.09
2.1e-06
4.4
5.1
2.8e-07
0.15
0.03
0.95
FALSE