Hub : Traits :

Hand grip strength (right)

1406 significantly associated models · 266 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	9576675	11137778	3	1	1.1e-11	8.1e-10	6.3e-03	80	KIF1B
2	1	23271432	23766233	1	1	2.5e-07	6.9e-07	3.7e-02	82	HTR1D
3	1	40791792	42187205	2	1	1.9e-10	5.8e-11	1.0e+00	100	SCMH1
4	1	149815323	151227371	3	1	4.3e-08	5.9e-08	1.0e+00	100	ADAMTSL4
5	1	159559531	161006019	1	1	6.2e-09	4.3e-08	3.5e-01	97	COPA
6	1	204982713	206329620	5	1	8.2e-17	1.4e-16	1.0e+00	100	NUCKS1
7	2	23604114	25889403	7	9	2.3e-14	8.0e-16	NaN	NaN	ADCY3 CENPO NCOA1 RP11-443B20.1 TP53I3
8	2	43417083	44920960	1	1	1.0e-08	5.6e-09	3.7e-02	87	LRPPRC
9	2	47979687	49429109	2	1	1.6e-08	3.6e-09	1.0e+00	100	PPP1R21
10	2	67709195	69180661	2	1	4.2e-08	3.6e-08	3.2e-01	97	PPP3R1
11	2	69978290	71471456	1	2	3.0e-17	3.5e-17	5.0e-03	89	TGFA
12	2	134513621	136403272	5	1	2.9e-12	1.6e-11	5.3e-01	99	LOC100129961
13	2	152099885	152836845	1	1	5.2e-08	1.3e-07	1.8e-01	94	NEB
14	2	171683107	173114238	1	1	1.1e-07	3.0e-07	2.6e-01	95	CYBRD1
15	2	178748168	180139951	1	1	2.2e-07	2.3e-06	9.8e-01	100	RP11-171I2.2
16	3	52020411	53860103	5	2	1.4e-10	2.3e-09	3.9e-01	98	GNL3 RFT1
17	3	140350567	141867638	1	1	6.7e-08	4.0e-09	1.0e+00	100	ZBTB38
18	4	305291	2058475	4	1	8.0e-10	4.9e-08	3.4e-03	71	CRIPAK
19	4	17104059	18507692	2	1	4.7e-19	3.6e-19	2.0e-03	88	DCAF16
20	5	129797129	132839137	16	7	5.4e-17	2.4e-16	1.0e+00	100	CDC42SE2 P4HA2-AS1 PDLIM4 RAPGEF6 SLC22A4 SLC22A5
21	6	1967240	3450266	1	1	2.9e-08	8.7e-07	7.2e-01	100	MYLK4
22	6	14551209	16209635	1	1	6.8e-08	1.3e-09	5.6e-03	79	JARID2
23	6	33856903	35362848	1	1	7.3e-10	6.6e-07	1.5e-03	59	C6orf106
24	6	80120201	81763771	2	2	2.0e-09	2.2e-06	8.6e-01	100	BCKDHB RP11-250B2.6
25	6	129638583	131163098	2	1	2.7e-20	9.4e-18	8.5e-01	100	L3MBTL3
26	6	154891396	156330580	1	1	7.3e-08	4.6e-10	4.5e-04	68	TFB1M
27	7	99275083	101185166	7	4	3.0e-09	6.2e-08	3.3e-01	97	GIGYF1 PILRA SRRT TFR2
28	7	119935156	121630503	1	1	1.8e-09	3.7e-08	8.5e-03	77	C7orf58
29	9	98515578	99932844	2	1	9.5e-09	2.7e-08	1.0e+00	100	CDC14B
30	9	126844856	128680148	7	1	4.1e-09	1.7e-08	4.4e-01	98	SCAI
31	9	136197834	137631198	1	1	9.2e-08	1.6e-07	1.0e+00	100	BRD3
32	10	78845149	80383574	2	1	4.8e-08	5.2e-08	2.4e-01	95	DLG5
33	10	80443273	82223767	5	2	1.6e-13	2.3e-10	8.2e-01	100	SFTPA2 ZCCHC24
34	10	98832260	99329418	1	1	7.7e-08	3.0e-06	6.8e-01	99	FRAT1
35	10	103527782	105282664	6	4	2.1e-11	2.7e-10	NaN	NaN	ACTR1A CYP17A1-AS1 SFXN2
36	10	120164251	121596611	1	1	2.3e-07	1.1e-08	8.0e-04	66	FAM45A
37	10	133754334	134268114	1	1	8.1e-08	8.4e-08	1.0e+00	100	DPYSL4
38	11	46917983	48485877	4	1	2.4e-09	6.2e-09	1.7e-01	94	FNBP4
39	11	66468469	67856510	1	1	1.5e-17	4.3e-17	1.0e+00	100	RAD9A
40	11	73024914	75075866	3	3	1.3e-20	4.7e-22	7.0e-01	100	C2CD3 POLD3
41	11	76537114	78216992	4	1	1.2e-13	2.8e-11	2.0e-02	88	AQP11
42	12	772458	1344141	1	1	7.5e-08	1.9e-06	3.2e-01	96	RAD52
43	12	14220891	16190627	8	1	7.6e-25	1.0e-21	3.4e-02	95	ARHGDIB
44	12	47671905	49133725	2	1	9.6e-09	1.3e-06	2.2e-01	94	TMEM106C
45	12	101713020	103148974	1	1	8.0e-08	2.5e-06	8.4e-02	86	CCDC53
46	12	123558705	125196704	5	1	1.9e-09	2.1e-08	3.1e-02	85	DNAH10
47	13	20282946	21799768	2	1	9.2e-08	3.8e-06	2.3e-01	93	CRYL1
48	13	50592874	52109040	1	2	1.3e-07	5.7e-19	3.4e-10	50	DLEU7
49	15	73524629	74915888	1	2	1.0e-12	2.2e-13	2.8e-07	51	LOXL1-AS1
50	15	74942759	76350952	3	1	2.4e-08	3.8e-07	1.0e+00	100	SNUPN
51	15	77023336	78474476	1	1	2.1e-11	5.9e-11	1.0e-02	85	HMG20A
52	16	1381714	2838000	4	3	3.1e-14	1.1e-14	3.8e-01	99	CASKIN1 SLC9A3R2 TSC2
53	16	24162204	25620010	1	1	1.1e-09	4.2e-09	1.0e+00	100	SLC5A11
54	16	27691641	30803299	9	2	5.1e-08	5.8e-08	1.0e+00	100	DOC2A NFATC2IP
55	16	69062879	70473934	4	1	5.3e-11	9.6e-11	2.6e-02	88	NOB1
56	16	88643457	90172696	3	2	8.1e-08	1.0e-09	5.2e-01	99	ANKRD11 ZNF276
57	17	7203350	7711960	1	1	7.8e-08	1.3e-06	3.8e-02	82	TNFSF12-TNFSF13
58	17	36211659	37644854	2	1	4.9e-17	1.0e-13	1.0e-01	95	PIP4K2B
59	17	41946180	43913030	16	3	2.7e-11	9.0e-12	2.4e-02	89	CRHR1 FZD2 PLCD3
60	17	44788310	47357969	11	2	5.8e-12	8.3e-12	3.5e-01	98	HOXB2 WNT3
61	17	60821100	62694738	11	2	2.3e-13	4.7e-12	1.0e+00	100	CD79B CYB561
62	17	62973790	64251733	1	1	2.0e-08	1.9e-08	4.2e-03	74	AXIN2
63	18	12304781	13822256	1	1	3.3e-08	8.0e-09	7.7e-05	53	CEP192
64	18	45873080	47686517	1	2	3.4e-09	4.2e-12	2.9e-03	82	DYM
65	19	1473344	2923263	1	1	2.3e-09	2.6e-09	1.0e+00	100	DOT1L
66	19	37350856	39002725	5	1	1.9e-08	1.9e-08	4.3e-04	61	ZNF571
67	19	52002729	52501321	1	1	1.0e-07	9.9e-11	3.2e-06	48	FPR1
68	20	32254831	35298668	34	7	7.4e-37	2.8e-38	NaN	NaN	CEP250 GGT7 MAP1LC3A MMP24-AS1 UQCC UQCC1
69	20	46838455	48591758	4	1	3.5e-10	1.6e-09	1.0e+00	100	ARFGEF2
70	21	46255195	46894021	1	1	2.5e-07	5.4e-08	2.6e-02	83	ADARB1

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Bipolar Disorder or Schizophrenia	1.36	3	1	2.2	0.00	1.0e+00	ACTR1A DOC2A SFXN2
Depressed Affect (Nagel 2018)	2.03	3	3	6.7	0.00	1.0e+00	CRHR1 FNBP4 WNT3
Depression (Nagel 2018)	1.36	1	0	0.0	0.00	1.0e+00	WNT3
Intelligence (Savage-Jansen 2018)	1.90	8	6	13.3	0.63	9.2e-02	ACTR1A ARFGEF2 CDC14B CRHR1 DCAF16 NFATC2IP TFB1M WNT3
Neuroticism (Nagel 2018)	2.24	4	3	6.7	-0.56	4.4e-01	CRHR1 CYP17A1-AS1 FNBP4 WNT3
Schizophrenia (2018)	1.37	2	1	2.2	0.00	1.0e+00	ACTR1A SFXN2
Worry (Nagel 2018)	2.19	6	4	8.9	-0.70	1.2e-01	ACTR1A CRHR1 CYP17A1-AS1 DOC2A FNBP4 WNT3
Crohns Disease (2017)	3.93	12	9	20.0	0.34	2.0e-01	ADCY3 CENPO GIGYF1 NFATC2IP P4HA2-AS1 PDLIM4 RAPGEF6 RFT1 RP11-443B20.1 SLC22A4 SLC22A5 ZBTB38
Irritable Bowel Disease (IBD)	3.24	11	7	15.6	0.13	6.4e-01	ADAMTSL4 ADCY3 CENPO GIGYF1 NFATC2IP P4HA2-AS1 PDLIM4 RAPGEF6 RP11-443B20.1 SLC22A4 SLC22A5
Ulcerative Colitis (UC)	1.76	2	0	0.0	0.00	1.0e+00	NFATC2IP SLC22A5
Reaction Time	1.86	3	0	0.0	0.57	4.3e-01	ADCY3 ARFGEF2 DNAH10
Verbal and Numeric Reasoning (VNR)	2.00	6	3	6.7	0.77	7.4e-02	ADCY3 ARFGEF2 CDC14B CRHR1 DCAF16 NFATC2IP
Breast Cancer	3.09	12	9	20.0	-0.41	1.3e-01	ADCY3 CENPO CRHR1 KIF1B L3MBTL3 P4HA2-AS1 RP11-443B20.1 SLC22A5 SNUPN TGFA WNT3 ZBTB38
Ovarian Cancer	1.47	3	2	4.4	0.00	1.0e+00	CRHR1 HOXB2 WNT3
Prostate Cancer	1.67	1	0	0.0	0.00	1.0e+00	NUCKS1
Body Mass Index (BMI) (2010)	2.67	4	3	6.7	-1.00	2.2e-06	ADCY3 FNBP4 NFATC2IP RP11-443B20.1
Coronary Artery Disease (CAD)	1.95	1	0	0.0	0.00	1.0e+00	DNAH10
Crohns Disease (2012)	3.11	6	3	6.7	0.60	1.6e-01	ADCY3 NFATC2IP P4HA2-AS1 PDLIM4 SLC22A4 SLC22A5
Fasting Glucose	1.62	1	0	0.0	0.00	1.0e+00	FNBP4
HDL Cholesterol	1.59	2	1	2.2	0.00	1.0e+00	DNAH10 GNL3
Lupus	1.48	1	0	0.0	0.00	1.0e+00	C6orf106
Neuroticism (2016)	1.54	3	2	4.4	0.00	1.0e+00	CRHR1 FNBP4 WNT3
Primary Biliary Cirrhosis	1.25	1	0	0.0	0.00	1.0e+00	WNT3
Schizophrenia (2014)	1.40	4	1	2.2	-0.51	4.9e-01	ACTR1A DOC2A GIGYF1 SFXN2
Triglycerides	1.14	1	0	0.0	0.00	1.0e+00	DNAH10
Ulcerative Colitis	1.89	1	0	0.0	0.00	1.0e+00	SLC22A5
Blood Eosinophil Count	5.61	18	12	26.7	-0.65	1.8e-03	ADCY3 BRD3 CENPO CRHR1 DOC2A HTR1D KIF1B NOB1 P4HA2-AS1 PDLIM4 PLCD3 RAPGEF6 RFT1 RP11-443B20.1 SLC22A4 SLC22A5 WNT3 ZNF571
Blood Platelet Count	2.13	24	19	42.2	-0.65	4.1e-04	AQP11 BRD3 CDC14B CRHR1 CYP17A1-AS1 DCAF16 DOC2A DYM FNBP4 FZD2 HMG20A KIF1B P4HA2-AS1 PDLIM4 PILRA RAPGEF6 SCMH1 SLC22A4 SLC22A5 SNUPN TFR2 TGFA TMEM106C ZCCHC24
Blood Red Count	2.82	22	18	40.0	0.01	9.5e-01	BRD3 CD79B CRHR1 DNAH10 DOC2A DOT1L GIGYF1 HOXB2 L3MBTL3 LOC100129961 MAP1LC3A MMP24-AS1 NFATC2IP NOB1 PLCD3 RAD9A SLC9A3R2 TFR2 TMEM106C TP53I3 WNT3 ZBTB38
Blood White Count	2.67	26	19	42.2	-0.51	6.1e-03	ACTR1A ADAMTSL4 ADCY3 CASKIN1 CDC14B CENPO CRHR1 DCAF16 DLG5 DNAH10 FRAT1 GGT7 L3MBTL3 MAP1LC3A NCOA1 NOB1 P4HA2-AS1 PDLIM4 RAPGEF6 SLC22A4 SLC22A5 SLC5A11 SLC9A3R2 SNUPN TP53I3 TSC2
Heel T-Score	4.46	38	32	71.1	-0.19	2.5e-01	ANKRD11 ARHGDIB AXIN2 BCKDHB C7orf58 CASKIN1 CEP192 CRHR1 CRIPAK CYBRD1 DCAF16 DLEU7 DNAH10 DOC2A DOT1L DPYSL4 FZD2 GGT7 GIGYF1 KIF1B L3MBTL3 MAP1LC3A PILRA PIP4K2B RFT1 SCMH1 SFTPA2 SLC5A11 SLC9A3R2 SRRT TFR2 TMEM106C TSC2 UQCC1 WNT3 ZBTB38 ZCCHC24 ZNF276
BMI	4.75	24	16	35.6	-0.43	2.3e-02	ACTR1A ADARB1 ADCY3 ARFGEF2 BRD3 CASKIN1 CENPO CYBRD1 DNAH10 DOC2A DPYSL4 DYM FNBP4 FRAT1 L3MBTL3 LOC100129961 LOXL1-AS1 NCOA1 NFATC2IP NOB1 RFT1 RP11-443B20.1 SLC5A11 SLC9A3R2
Height	13.34	80	73	162.2	0.87	9.0e-30	ADCY3 AQP11 ARFGEF2 AXIN2 BCKDHB BRD3 C6orf106 C7orf58 CASKIN1 CCDC53 CD79B CDC14B CDC42SE2 CENPO CEP192 CEP250 CRHR1 CRIPAK CRYL1 CYB561 CYBRD1 CYP17A1-AS1 DCAF16 DLEU7 DLG5 DNAH10 DOC2A DOT1L DYM FAM45A FNBP4 FZD2 GGT7 GIGYF1 GNL3 HOXB2 HTR1D KIF1B L3MBTL3 LOXL1-AS1 MAP1LC3A MMP24-AS1 NCOA1 NOB1 NUCKS1 P4HA2-AS1 PDLIM4 PILRA PIP4K2B PLCD3 POLD3 PPP3R1 RAD9A RAPGEF6 RFT1 RP11-171I2.2 RP11-250B2.6 RP11-443B20.1 SCAI SCMH1 SFTPA2 SFXN2 SLC22A4 SLC22A5 SLC5A11 SLC9A3R2 SNUPN SRRT TFB1M TMEM106C TNFSF12-TNFSF13 TP53I3 TSC2 UQCC UQCC1 WNT3 ZBTB38 ZCCHC24 ZNF276 ZNF571
Waist Hip Ratio (WHR)	3.48	24	18	40.0	-0.43	3.8e-02	C7orf58 CCDC53 CD79B CEP250 CRHR1 CYBRD1 DNAH10 DOT1L DYM GNL3 HTR1D L3MBTL3 NCOA1 PIP4K2B POLD3 RAD9A RP11-250B2.6 RP11-443B20.1 SNUPN TNFSF12-TNFSF13 UQCC UQCC1 WNT3 ZBTB38
Systolic Blood Pressure	2.90	24	16	35.6	0.12	5.5e-01	ACTR1A ADCY3 ARFGEF2 CENPO CEP250 CRHR1 CYBRD1 CYP17A1-AS1 DCAF16 FNBP4 LOC100129961 LRPPRC NCOA1 PLCD3 PPP3R1 RP11-443B20.1 SCMH1 SFXN2 SLC5A11 SLC9A3R2 TFR2 TMEM106C TNFSF12-TNFSF13 UQCC
Smoking Status	2.03	6	2	4.4	0.41	4.2e-01	ACTR1A CYP17A1-AS1 NOB1 SCAI SLC5A11 WNT3
Allergy or Eczema	1.53	6	1	2.2	-0.09	8.5e-01	HTR1D L3MBTL3 NFATC2IP P4HA2-AS1 SLC22A5 ZBTB38
Cardiovascular Disease	1.42	8	4	8.9	-0.99	2.5e-07	DCAF16 JARID2 LRPPRC NFATC2IP PPP3R1 SFXN2 TMEM106C TNFSF12-TNFSF13
Hypothyroidism (self reported)	1.07	1	1	2.2	0.00	1.0e+00	GIGYF1
Respiratory disease	2.25	7	5	11.1	-0.71	4.9e-02	HOXB2 KIF1B P4HA2-AS1 PDLIM4 SLC22A4 SLC22A5 TNFSF12-TNFSF13
Type 2 Diabetes (T2D) (2018)	1.50	4	0	0.0	-1.00	8.2e-04	FNBP4 GIGYF1 NOB1 SNUPN
Lung FEV1/FVC ratio	2.18	20	11	24.4	0.11	5.9e-01	ACTR1A ADCY3 ARFGEF2 C6orf106 CENPO CEP250 CRHR1 GGT7 HOXB2 LOXL1-AS1 MAP1LC3A NEB NUCKS1 P4HA2-AS1 PIP4K2B RP11-443B20.1 SLC22A5 UQCC UQCC1 ZBTB38
Lung FVC	3.97	34	21	46.7	-0.03	8.8e-01	ADAMTSL4 ARFGEF2 BCKDHB CD79B CEP250 CRHR1 DCAF16 DLEU7 DOT1L FZD2 HOXB2 KIF1B LOC100129961 LOXL1-AS1 MAP1LC3A MMP24-AS1 NCOA1 NFATC2IP NOB1 NUCKS1 P4HA2-AS1 PDLIM4 PPP1R21 RAD9A RP11-171I2.2 SLC22A4 SLC22A5 SNUPN TFB1M TMEM106C UQCC UQCC1 WNT3 ZBTB38
Neuroticism	2.09	3	3	6.7	0.00	1.0e+00	CRHR1 FNBP4 WNT3
Chronotype (morning person)	1.80	5	1	2.2	-0.51	3.8e-01	ADAMTSL4 ADCY3 CRIPAK CYB561 RP11-443B20.1
Hair Pigment	3.15	21	18	40.0	-0.36	8.1e-02	ADCY3 ANKRD11 CEP250 CRHR1 GGT7 GIGYF1 HTR1D KIF1B L3MBTL3 LOC100129961 MAP1LC3A MMP24-AS1 NUCKS1 RP11-443B20.1 SRRT TFR2 UQCC UQCC1 WNT3 ZBTB38 ZNF276
Tanning	2.63	10	9	20.0	0.65	1.3e-02	ADAMTSL4 ADCY3 ANKRD11 CEP250 GGT7 MAP1LC3A MMP24-AS1 RP11-443B20.1 UQCC ZNF276
Hand grip strength (left)	13.96	91	68	151.1	0.99	5.3e-101	ACTR1A ADAMTSL4 ADARB1 ADCY3 AQP11 ARFGEF2 ARHGDIB AXIN2 BCKDHB BRD3 C2CD3 C6orf106 C7orf58 CASKIN1 CCDC53 CD79B CDC14B CDC42SE2 CENPO CEP192 CEP250 COPA CRHR1 CRIPAK CRYL1 CYB561 CYP17A1-AS1 DCAF16 DLEU7 DLG5 DNAH10 DOC2A DOT1L DYM FNBP4 FPR1 FRAT1 FZD2 GGT7 HMG20A HOXB2 HTR1D KIF1B L3MBTL3 LOC100129961 LOXL1-AS1 LRPPRC MAP1LC3A MMP24-AS1 MYLK4 NCOA1 NEB NOB1 NUCKS1 P4HA2-AS1 PDLIM4 PILRA PIP4K2B PLCD3 POLD3 PPP1R21 PPP3R1 RAD9A RAPGEF6 RFT1 RP11-171I2.2 RP11-250B2.6 RP11-443B20.1 SCAI SCMH1 SFTPA2 SFXN2 SLC22A4 SLC22A5 SLC5A11 SLC9A3R2 SRRT TFB1M TFR2 TGFA TMEM106C TNFSF12-TNFSF13 TP53I3 TSC2 UQCC UQCC1 WNT3 ZBTB38 ZCCHC24 ZNF276 ZNF571
Number of treatments/medications taken	1.69	2	0	0.0	0.00	1.0e+00	DCAF16 NUCKS1
Sensitivity / hurt feelings	2.16	2	2	4.4	0.00	1.0e+00	CRHR1 WNT3
Frequency of depressed mood in last 2 weeks	1.42	2	0	0.0	0.00	1.0e+00	ARFGEF2 WNT3
Relative age of first facial hair	2.60	4	3	6.7	-1.00	2.6e-03	C6orf106 CRHR1 WNT3 ZBTB38
Systolic blood pressure, automated reading	2.25	11	9	20.0	0.07	8.4e-01	CRHR1 DCAF16 FNBP4 LOC100129961 NCOA1 PPP3R1 RP11-443B20.1 SFXN2 SLC5A11 SLC9A3R2 TNFSF12-TNFSF13
Medication: Metformin	1.75	1	1	2.2	0.00	1.0e+00	FNBP4
Pack years adult smoking proportion	1.84	2	0	0.0	0.00	1.0e+00	ADARB1 CYB561
Impedance of leg (right)	3.08	23	17	37.8	-0.43	2.2e-02	ACTR1A ADARB1 ADCY3 ANKRD11 CD79B CDC42SE2 CEP250 CYBRD1 DLEU7 DOC2A FNBP4 L3MBTL3 MMP24-AS1 NFATC2IP NUCKS1 PLCD3 RAD9A RAPGEF6 RFT1 RP11-443B20.1 TMEM106C UQCC UQCC1
Leg fat-free mass (left)	7.96	51	40	88.9	0.90	4.8e-21	ACTR1A ADARB1 ANKRD11 AXIN2 C6orf106 CASKIN1 CD79B CDC14B CDC42SE2 CEP250 CRIPAK CYBRD1 CYP17A1-AS1 DCAF16 DLEU7 DLG5 DOC2A DOT1L DYM FAM45A FNBP4 FZD2 GGT7 HTR1D L3MBTL3 LOXL1-AS1 MAP1LC3A MMP24-AS1 NCOA1 NFATC2IP NUCKS1 P4HA2-AS1 PDLIM4 PIP4K2B PLCD3 PPP3R1 RAD9A RAPGEF6 RP11-250B2.6 SCMH1 SFXN2 SLC22A4 SLC22A5 SLC5A11 SLC9A3R2 TNFSF12-TNFSF13 TP53I3 UQCC UQCC1 ZBTB38 ZCCHC24
Trunk fat percentage	4.17	23	16	35.6	-0.35	8.1e-02	ADARB1 ADCY3 ARFGEF2 BRD3 CASKIN1 CENPO CRHR1 DNAH10 DOC2A DPYSL4 FNBP4 FZD2 GGT7 LOC100129961 NFATC2IP NOB1 RAD9A RP11-443B20.1 SLC5A11 SLC9A3R2 TNFSF12-TNFSF13 WNT3 ZBTB38
Current tobacco smoking	1.59	4	1	2.2	0.63	3.7e-01	ACTR1A CYP17A1-AS1 SCAI SLC5A11
Average weekly fortified wine intake	1.44	1	0	0.0	0.00	1.0e+00	SLC5A11
Maternal smoking around birth	1.47	2	1	2.2	0.00	1.0e+00	ACTR1A SLC5A11
Fed-up feelings	1.58	2	2	4.4	0.00	1.0e+00	CRHR1 WNT3
Relative age voice broke	2.15	3	2	4.4	0.00	1.0e+00	CRHR1 UQCC WNT3
Age when periods started (menarche)	2.15	7	3	6.7	0.69	3.8e-02	ADCY3 CENPO FNBP4 NOB1 NUCKS1 RP11-443B20.1 SLC22A5
Heel bone mineral density (BMD) T-score, automated (left)	2.83	6	4	8.9	-0.37	4.7e-01	C7orf58 CRIPAK DNAH10 FZD2 L3MBTL3 SCMH1
High blood pressure	1.89	11	6	13.3	-0.67	1.7e-02	DCAF16 FNBP4 JARID2 NCOA1 P4HA2-AS1 PDLIM4 SFXN2 SLC22A4 SLC22A5 SLC5A11 TNFSF12-TNFSF13
Hayfever, allergic rhinitis or eczema	1.60	4	2	4.4	-0.64	2.5e-01	HTR1D P4HA2-AS1 SLC22A5 ZBTB38
Multivitamins +/- minerals	1.58	1	0	0.0	0.00	1.0e+00	NUCKS1
Supplements: Glucosamine	1.48	1	0	0.0	0.00	1.0e+00	ARHGDIB
Diverticular disease/diverticulitis (self-reported)	1.52	1	0	0.0	0.00	1.0e+00	FZD2
Sitting height	13.22	67	61	135.6	0.91	3.6e-30	ADCY3 ARFGEF2 ARHGDIB AXIN2 BCKDHB BRD3 C6orf106 CASKIN1 CCDC53 CD79B CDC14B CDC42SE2 CENPO CEP192 CEP250 CRHR1 CRIPAK CRYL1 CYB561 CYBRD1 CYP17A1-AS1 DCAF16 DLEU7 DLG5 DOC2A DOT1L DYM FAM45A FNBP4 FZD2 GGT7 HTR1D JARID2 L3MBTL3 LOXL1-AS1 MAP1LC3A MMP24-AS1 NCOA1 NOB1 NUCKS1 P4HA2-AS1 PDLIM4 PIP4K2B PLCD3 POLD3 PPP3R1 RAD9A RAPGEF6 RFT1 RP11-171I2.2 RP11-250B2.6 RP11-443B20.1 SCMH1 SFTPA2 SLC22A4 SLC22A5 SLC9A3R2 SNUPN TFB1M TNFSF12-TNFSF13 TP53I3 TSC2 UQCC UQCC1 WNT3 ZBTB38 ZCCHC24
High blood pressure (mother)	1.54	1	0	0.0	0.00	1.0e+00	TMEM106C
Body mass index (BMI)	4.32	17	10	22.2	-0.45	4.5e-02	ACTR1A ADARB1 ADCY3 ARFGEF2 CENPO DOC2A DPYSL4 FNBP4 L3MBTL3 LOC100129961 NCOA1 NFATC2IP NOB1 RFT1 RP11-443B20.1 SLC5A11 SLC9A3R2
Impedance of leg (left)	3.04	22	15	33.3	-0.42	2.9e-02	ACTR1A ADCY3 ANKRD11 CD79B CDC42SE2 CEP250 CYBRD1 DLEU7 DOC2A FNBP4 L3MBTL3 MMP24-AS1 NFATC2IP NUCKS1 PLCD3 RAD9A RAPGEF6 RP11-443B20.1 TMEM106C UQCC UQCC1 WNT3
Leg predicted mass (left)	7.94	51	40	88.9	0.90	5.8e-21	ACTR1A ADARB1 ANKRD11 AXIN2 C6orf106 CASKIN1 CD79B CDC14B CDC42SE2 CEP250 CRIPAK CYBRD1 CYP17A1-AS1 DCAF16 DLEU7 DLG5 DOC2A DOT1L DYM FAM45A FNBP4 FZD2 GGT7 HTR1D L3MBTL3 LOXL1-AS1 MAP1LC3A MMP24-AS1 NCOA1 NFATC2IP NUCKS1 P4HA2-AS1 PDLIM4 PIP4K2B PLCD3 PPP3R1 RAD9A RAPGEF6 RP11-250B2.6 SCMH1 SFXN2 SLC22A4 SLC22A5 SLC5A11 SLC9A3R2 TNFSF12-TNFSF13 TP53I3 UQCC UQCC1 ZBTB38 ZCCHC24
Trunk fat mass	4.33	26	24	53.3	0.14	4.7e-01	ADARB1 ADCY3 C6orf106 CASKIN1 CENPO CEP250 CRHR1 DNAH10 DOC2A DPYSL4 FNBP4 FZD2 GGT7 L3MBTL3 LOC100129961 NFATC2IP NOB1 RAD9A RP11-443B20.1 SLC5A11 SLC9A3R2 TSC2 UQCC UQCC1 WNT3 ZBTB38
Waist circumference	3.78	17	13	28.9	-0.07	7.6e-01	ADARB1 ADCY3 CASKIN1 CENPO CRIPAK DOC2A DPYSL4 FNBP4 GGT7 HOXB2 NFATC2IP NOB1 RAD9A RP11-443B20.1 SLC5A11 SLC9A3R2 ZBTB38
Number of incorrect matches in round	2.20	3	1	2.2	0.00	1.0e+00	CYP17A1-AS1 DOC2A LOC100129961
Past tobacco smoking	2.16	5	2	4.4	-0.42	4.8e-01	ACTR1A ADCY3 CYP17A1-AS1 MAP1LC3A NOB1
Alcohol usually taken with meals	1.67	1	0	0.0	0.00	1.0e+00	ACTR1A
Nervous feelings	1.77	5	3	6.7	-0.99	4.5e-04	ACTR1A CRHR1 CYP17A1-AS1 DOC2A WNT3
Frequency of tenseness / restlessness in last 2 weeks	1.61	2	2	4.4	0.00	1.0e+00	CRHR1 WNT3
Hearing difficulty/problems with background noise	1.40	2	1	2.2	0.00	1.0e+00	CRHR1 NUCKS1
Hair/balding pattern: Pattern 2	1.83	2	1	2.2	0.00	1.0e+00	CRHR1 WNT3
Had menopause	0.99	1	0	0.0	0.00	1.0e+00	L3MBTL3
Forced vital capacity (FVC)	7.25	42	31	68.9	0.93	6.3e-22	ADCY3 AQP11 ARFGEF2 AXIN2 BCKDHB C6orf106 CD79B CDC14B CENPO CEP250 CRHR1 CYB561 CYBRD1 CYP17A1-AS1 DCAF16 DLG5 DYM FNBP4 FZD2 GGT7 L3MBTL3 LOC100129961 LOXL1-AS1 NCOA1 NOB1 PIP4K2B PPP3R1 RAD9A RP11-250B2.6 RP11-443B20.1 SCAI SCMH1 SFTPA2 SLC9A3R2 SNUPN SRRT TP53I3 UQCC WNT3 ZBTB38 ZCCHC24 ZNF276
Heel bone mineral density (BMD) T-score, automated (right)	2.74	7	3	6.7	-0.45	3.1e-01	C7orf58 CRIPAK DCAF16 DNAH10 FZD2 SCMH1 ZBTB38
Ever unenthusiastic/disinterested for a whole week	1.47	1	0	0.0	0.00	1.0e+00	WNT3
Qualifications: None of the above	1.59	7	1	2.2	-0.56	1.9e-01	ACTR1A CEP192 NFATC2IP RFT1 SCAI SLC5A11 UQCC1
Mouth/teeth dental problems	1.51	1	0	0.0	0.00	1.0e+00	WNT3
Allergy	1.94	6	6	13.3	0.83	2.1e-02	KIF1B P4HA2-AS1 PDLIM4 SLC22A4 SLC22A5 ZBTB38
Fluid intelligence score	1.88	2	2	4.4	0.00	1.0e+00	DCAF16 NFATC2IP
Illnesses of siblings	1.49	1	0	0.0	0.00	1.0e+00	SLC5A11
Neuroticism score	2.03	3	3	6.7	0.00	1.0e+00	CRHR1 FNBP4 WNT3
Weight	5.96	41	36	80.0	0.68	2.5e-07	ACTR1A ADARB1 ADCY3 C6orf106 CASKIN1 CD79B CEP250 CRIPAK CYBRD1 CYP17A1-AS1 DCAF16 DLEU7 DOC2A DOT1L DPYSL4 FAM45A FNBP4 FZD2 GGT7 HTR1D L3MBTL3 MAP1LC3A MMP24-AS1 NFATC2IP NOB1 NUCKS1 P4HA2-AS1 PDLIM4 RAD9A RAPGEF6 RP11-443B20.1 SCMH1 SLC22A4 SLC22A5 SLC5A11 SLC9A3R2 TSC2 UQCC UQCC1 ZBTB38 ZCCHC24
Impedance of arm (right)	2.76	28	17	37.8	-0.67	1.0e-04	ACTR1A ANKRD11 ARHGDIB CASKIN1 CD79B CEP250 COPA CRHR1 CYBRD1 DLEU7 DNAH10 DOC2A DPYSL4 FPR1 KIF1B L3MBTL3 LOXL1-AS1 MAP1LC3A MMP24-AS1 NEB NUCKS1 PPP3R1 RFT1 SCMH1 SLC9A3R2 TMEM106C TNFSF12-TNFSF13 WNT3
Arm fat percentage (right)	5.33	20	14	31.1	-0.70	1.9e-04	ADARB1 ADCY3 ARFGEF2 BRD3 CD79B CDC14B CENPO DCAF16 DNAH10 DOC2A DPYSL4 FNBP4 FZD2 LOC100129961 NCOA1 NFATC2IP NOB1 RP11-443B20.1 SLC5A11 TNFSF12-TNFSF13
Trunk fat-free mass	10.60	62	52	115.6	0.92	3.4e-28	ACTR1A ANKRD11 ARFGEF2 ARHGDIB AXIN2 BCKDHB BRD3 C6orf106 CASKIN1 CCDC53 CD79B CDC14B CDC42SE2 CENPO CEP192 CEP250 CRIPAK CRYL1 CYBRD1 CYP17A1-AS1 DCAF16 DLEU7 DLG5 DNAH10 DOC2A DOT1L DYM FAM45A GGT7 HTR1D JARID2 L3MBTL3 LOXL1-AS1 MAP1LC3A MMP24-AS1 NCOA1 NFATC2IP NUCKS1 P4HA2-AS1 PDLIM4 PIP4K2B PLCD3 POLD3 PPP3R1 RAD9A RAPGEF6 RP11-250B2.6 SCMH1 SFTPA2 SFXN2 SLC22A4 SLC22A5 SLC5A11 SLC9A3R2 SNUPN TFB1M TNFSF12-TNFSF13 TP53I3 UQCC UQCC1 ZBTB38 ZCCHC24
Hip circumference	4.70	32	21	46.7	0.34	4.5e-02	ACTR1A ADARB1 ADCY3 C6orf106 CASKIN1 CD79B CENPO CEP250 CYBRD1 CYP17A1-AS1 DCAF16 DNAH10 DOC2A DOT1L DPYSL4 FNBP4 GGT7 HTR1D L3MBTL3 LOC100129961 MAP1LC3A MMP24-AS1 NFATC2IP NOB1 RAD9A RP11-443B20.1 SCMH1 SLC5A11 SLC9A3R2 UQCC UQCC1 ZBTB38
Time employed in main current job	1.51	1	1	2.2	0.00	1.0e+00	WNT3
Father's age at death	1.40	1	0	0.0	0.00	1.0e+00	SLC22A5
Worrier / anxious feelings	2.14	5	4	8.9	-1.00	2.1e-06	ACTR1A CRHR1 CYP17A1-AS1 SFXN2 WNT3
Frequency of tiredness / lethargy in last 2 weeks	1.73	1	0	0.0	0.00	1.0e+00	POLD3
Hair/balding pattern: Pattern 3	2.54	3	2	4.4	0.00	1.0e+00	CRHR1 MAP1LC3A WNT3
Number of live births	1.21	2	0	0.0	0.00	1.0e+00	CRHR1 WNT3
Forced expiratory volume in 1-second (FEV1)	6.07	38	21	46.7	0.93	2.1e-19	ADCY3 AQP11 ARFGEF2 AXIN2 BCKDHB C6orf106 CD79B CDC14B CENPO CEP250 CRHR1 CYB561 CYBRD1 CYP17A1-AS1 DCAF16 DLG5 FZD2 GGT7 L3MBTL3 LOC100129961 LOXL1-AS1 NCOA1 NOB1 P4HA2-AS1 RAD9A RP11-250B2.6 RP11-443B20.1 SCAI SCMH1 SLC22A5 SLC9A3R2 SNUPN TP53I3 UQCC WNT3 ZBTB38 ZCCHC24 ZNF276
Pulse rate	2.59	5	3	6.7	0.60	2.8e-01	DLEU7 GIGYF1 SRRT TFR2 ZBTB38
Qualifications: A levels/AS levels or equivalent	1.74	8	0	0.0	0.67	6.9e-02	ACTR1A ARFGEF2 CEP192 CRHR1 DCAF16 SLC5A11 UQCC UQCC1
Mouth/teeth dental problems: Dentures	1.58	1	0	0.0	0.00	1.0e+00	ADCY3
Asthma	2.58	6	5	11.1	-0.85	1.4e-02	HOXB2 KIF1B P4HA2-AS1 PDLIM4 SLC22A4 SLC22A5
Medication: Cholesterol lowering	1.15	1	0	0.0	0.00	1.0e+00	TMEM106C
Forced expiratory volume in 1-second (FEV1), Best measure	5.60	32	17	37.8	0.94	1.0e-16	ADCY3 ARFGEF2 AXIN2 BRD3 C6orf106 CD79B CDC14B CEP250 CRHR1 CYB561 CYBRD1 DCAF16 DLG5 FNBP4 FZD2 GGT7 L3MBTL3 LOC100129961 LOXL1-AS1 MMP24-AS1 NCOA1 NOB1 RAD9A RP11-250B2.6 RP11-443B20.1 SCMH1 SLC22A4 SNUPN UQCC WNT3 ZBTB38 ZCCHC24
Impedance of arm (left)	2.71	25	15	33.3	-0.63	6.6e-04	ACTR1A ANKRD11 ARHGDIB CD79B COPA CRHR1 CYBRD1 DLEU7 DNAH10 DOC2A FPR1 KIF1B L3MBTL3 LOXL1-AS1 MAP1LC3A MMP24-AS1 NEB NUCKS1 PLCD3 RFT1 SCMH1 SLC9A3R2 TMEM106C TNFSF12-TNFSF13 WNT3
Arm fat mass (right)	4.20	19	14	31.1	-0.19	3.9e-01	ADARB1 ADCY3 CASKIN1 CENPO DNAH10 DOC2A DPYSL4 FNBP4 FZD2 GGT7 L3MBTL3 LOC100129961 NFATC2IP NOB1 RP11-443B20.1 SLC5A11 SLC9A3R2 UQCC ZBTB38
Trunk predicted mass	10.60	62	52	115.6	0.92	4.4e-28	ACTR1A ANKRD11 ARFGEF2 ARHGDIB AXIN2 BCKDHB BRD3 C6orf106 CASKIN1 CCDC53 CD79B CDC14B CDC42SE2 CENPO CEP192 CEP250 CRIPAK CRYL1 CYBRD1 CYP17A1-AS1 DCAF16 DLEU7 DLG5 DNAH10 DOC2A DOT1L DYM FAM45A GGT7 HTR1D JARID2 L3MBTL3 LOXL1-AS1 MAP1LC3A MMP24-AS1 NCOA1 NFATC2IP NUCKS1 P4HA2-AS1 PDLIM4 PIP4K2B PLCD3 POLD3 PPP3R1 RAD9A RAPGEF6 RP11-250B2.6 SCAI SCMH1 SFTPA2 SFXN2 SLC22A4 SLC22A5 SLC5A11 SLC9A3R2 SNUPN TNFSF12-TNFSF13 TP53I3 UQCC UQCC1 ZBTB38 ZCCHC24
Standing height	13.26	73	68	151.1	0.91	1.3e-33	ADCY3 AQP11 ARFGEF2 AXIN2 BCKDHB BRD3 C6orf106 C7orf58 CASKIN1 CCDC53 CD79B CDC14B CDC42SE2 CENPO CEP192 CEP250 CRHR1 CRIPAK CRYL1 CYB561 CYBRD1 CYP17A1-AS1 DCAF16 DLEU7 DLG5 DNAH10 DOC2A DOT1L DYM FAM45A FNBP4 FZD2 GGT7 GNL3 HTR1D L3MBTL3 LOXL1-AS1 MAP1LC3A MMP24-AS1 NCOA1 NOB1 NUCKS1 P4HA2-AS1 PDLIM4 PIP4K2B PLCD3 POLD3 PPP3R1 RAD9A RAPGEF6 RFT1 RP11-171I2.2 RP11-250B2.6 RP11-443B20.1 SCMH1 SFTPA2 SFXN2 SLC22A4 SLC22A5 SLC5A11 SLC9A3R2 SNUPN SRRT TFB1M TNFSF12-TNFSF13 TP53I3 TSC2 UQCC UQCC1 WNT3 ZBTB38 ZCCHC24 ZNF276
Tense / 'highly strung'	1.42	1	0	0.0	0.00	1.0e+00	NUCKS1
Hair/balding pattern: Pattern 4	3.26	6	4	8.9	0.39	4.4e-01	CRHR1 DLG5 KIF1B MAP1LC3A WNT3 ZBTB38
Birth weight of first child	2.13	3	1	2.2	0.00	1.0e+00	ARFGEF2 DCAF16 ZBTB38
Peak expiratory flow (PEF)	5.18	23	11	24.4	0.93	7.8e-11	ANKRD11 AQP11 C6orf106 CD79B CEP250 CRHR1 CYP17A1-AS1 DCAF16 GGT7 HOXB2 MAP1LC3A NCOA1 NUCKS1 PPP1R21 RAD9A SCAI SLC9A3R2 TMEM106C TP53I3 UQCC UQCC1 WNT3 ZNF276
Qualifications: O levels/GCSEs or equivalent	1.29	1	0	0.0	0.00	1.0e+00	DPYSL4
Medication: Paracetamol	1.76	2	2	4.4	0.00	1.0e+00	CRHR1 WNT3
Headache pain in last month	1.81	3	3	6.7	0.00	1.0e+00	ADAMTSL4 CRHR1 WNT3
Medication for cholesterol, blood pressure or diabetes	1.28	2	0	0.0	0.00	1.0e+00	JARID2 TMEM106C
Hypothyroidism/myxoedema (self-reported)	1.13	1	1	2.2	0.00	1.0e+00	GIGYF1
Medication: Amlodipine	1.39	1	0	0.0	0.00	1.0e+00	TNFSF12-TNFSF13
Birth weight	2.33	7	1	2.2	0.94	1.3e-03	CYP17A1-AS1 DCAF16 HTR1D L3MBTL3 NUCKS1 RFT1 SFXN2
Forced vital capacity (FVC), Best measure	6.95	41	29	64.4	0.93	2.2e-21	ADCY3 ARFGEF2 AXIN2 BCKDHB C6orf106 CD79B CDC14B CENPO CEP250 CRHR1 CYB561 CYBRD1 CYP17A1-AS1 DCAF16 DLG5 DYM FNBP4 FZD2 GGT7 L3MBTL3 LOC100129961 LOXL1-AS1 NCOA1 NOB1 PIP4K2B PPP3R1 RAD9A RFT1 RP11-250B2.6 RP11-443B20.1 SCMH1 SFTPA2 SNUPN SRRT TP53I3 UQCC UQCC1 WNT3 ZBTB38 ZCCHC24 ZNF276
Body fat percentage	4.59	22	14	31.1	-0.64	6.5e-04	ADARB1 ADCY3 ARFGEF2 BRD3 CD79B CDC14B CENPO CEP192 DCAF16 DNAH10 DOC2A DPYSL4 FNBP4 FZD2 LOC100129961 NCOA1 NFATC2IP NOB1 RP11-443B20.1 SLC5A11 TNFSF12-TNFSF13 ZBTB38
Leg fat percentage (right)	4.94	22	17	37.8	-0.69	9.4e-05	ADARB1 ADCY3 ARFGEF2 BRD3 CD79B CDC14B CENPO CEP192 CEP250 DCAF16 DNAH10 DOC2A DPYSL4 FNBP4 LOC100129961 NCOA1 NFATC2IP NOB1 RP11-443B20.1 SLC5A11 SLC9A3R2 UQCC
Arm fat-free mass (right)	9.25	62	47	104.4	0.92	4.2e-28	ACTR1A ADARB1 ANKRD11 ARFGEF2 ARHGDIB AXIN2 BCKDHB BRD3 C2CD3 C6orf106 CASKIN1 CD79B CDC14B CDC42SE2 CEP192 CEP250 CRIPAK CRYL1 CYBRD1 CYP17A1-AS1 DCAF16 DLEU7 DLG5 DNAH10 DOC2A DOT1L DPYSL4 DYM FAM45A GGT7 HMG20A HTR1D L3MBTL3 LOXL1-AS1 MAP1LC3A MMP24-AS1 NCOA1 NFATC2IP NUCKS1 P4HA2-AS1 PDLIM4 PIP4K2B PLCD3 POLD3 PPP3R1 RAD9A RAPGEF6 RP11-250B2.6 SCMH1 SFXN2 SLC22A4 SLC22A5 SLC5A11 SLC9A3R2 SNUPN TNFSF12-TNFSF13 TP53I3 UQCC UQCC1 ZBTB38 ZCCHC24 ZNF276
Comparative body size at age 10	10.82	8	7	15.6	-0.78	2.9e-03	ADCY3 CENPO DOT1L FNBP4 NCOA1 NFATC2IP NUCKS1 RP11-443B20.1
Worry too long after embarrassment	1.45	2	0	0.0	0.00	1.0e+00	CRHR1 WNT3
Age at first live birth	1.11	1	0	0.0	0.00	1.0e+00	DCAF16
Qualifications: College or University degree	1.86	10	5	11.1	0.49	1.5e-01	ACTR1A ARFGEF2 CDC14B CRHR1 DCAF16 NFATC2IP SLC5A11 UQCC UQCC1 WNT3
Medication for pain relief, constipation, heartburn	1.70	3	2	4.4	0.00	1.0e+00	CRHR1 FZD2 WNT3
Medication: Blood pressure	1.84	2	0	0.0	0.00	1.0e+00	DCAF16 JARID2
Migraine (self-reported)	1.63	2	0	0.0	0.00	1.0e+00	ADAMTSL4 SFXN2
Medication: Seretide 50 evohaler	1.65	3	0	0.0	-1.00	1.1e-03	P4HA2-AS1 SLC22A4 SLC22A5
Mean time to correctly identify matches	1.79	3	0	0.0	0.00	1.0e+00	ARFGEF2 L3MBTL3 NUCKS1
Whole body fat mass	4.23	24	20	44.4	0.05	8.2e-01	ADARB1 ADCY3 C6orf106 CASKIN1 CENPO CEP250 DNAH10 DOC2A DPYSL4 FNBP4 FZD2 GGT7 L3MBTL3 LOC100129961 NFATC2IP NOB1 RAD9A RP11-443B20.1 SLC5A11 SLC9A3R2 TSC2 UQCC UQCC1 ZBTB38
Leg fat mass (right)	4.03	19	14	31.1	-0.18	4.2e-01	ACTR1A ADARB1 ADCY3 CASKIN1 CENPO DNAH10 DOC2A DPYSL4 FNBP4 GGT7 L3MBTL3 LOC100129961 NFATC2IP NOB1 RAD9A RP11-443B20.1 SLC5A11 SLC9A3R2 ZBTB38
Arm predicted mass (right)	9.18	61	47	104.4	0.92	4.4e-28	ACTR1A ADARB1 ANKRD11 ARFGEF2 ARHGDIB AXIN2 BRD3 C2CD3 C6orf106 CASKIN1 CD79B CDC14B CDC42SE2 CEP192 CEP250 CRIPAK CRYL1 CYBRD1 CYP17A1-AS1 DCAF16 DLEU7 DLG5 DNAH10 DOC2A DOT1L DPYSL4 DYM FAM45A GGT7 HMG20A HTR1D L3MBTL3 LOXL1-AS1 MAP1LC3A MMP24-AS1 NCOA1 NFATC2IP NUCKS1 P4HA2-AS1 PDLIM4 PLCD3 POLD3 PPP3R1 RAD9A RAPGEF6 RP11-250B2.6 SCMH1 SFXN2 SLC22A4 SLC22A5 SLC5A11 SLC9A3R2 SNUPN TNFSF12-TNFSF13 TP53I3 TSC2 UQCC UQCC1 ZBTB38 ZCCHC24 ZNF276
Pulse rate, automated reading	3.56	10	5	11.1	0.49	1.5e-01	C2CD3 CDC14B CRIPAK GIGYF1 GNL3 LOC100129961 NCOA1 SRRT TFR2 ZBTB38
Alcohol intake frequency.	2.03	7	5	11.1	-0.33	4.7e-01	CRHR1 DOC2A FNBP4 NFATC2IP PILRA TFR2 WNT3
Comparative height size at age 10	10.30	56	45	100.0	0.91	2.9e-26	ADCY3 ARFGEF2 AXIN2 C6orf106 CASKIN1 CCDC53 CD79B CDC14B CENPO CEP250 CRHR1 CRIPAK CYBRD1 CYP17A1-AS1 DCAF16 DLEU7 DLG5 DNAH10 DOC2A DOT1L DYM FAM45A FZD2 GGT7 HTR1D L3MBTL3 LOXL1-AS1 MAP1LC3A MMP24-AS1 NCOA1 NFATC2IP NUCKS1 P4HA2-AS1 PDLIM4 PIP4K2B RAD9A RAPGEF6 RFT1 RP11-171I2.2 RP11-250B2.6 RP11-443B20.1 SCMH1 SFXN2 SLC22A4 SLC22A5 SLC9A3R2 SNUPN TFB1M TP53I3 TSC2 UQCC UQCC1 WNT3 ZBTB38 ZCCHC24 ZNF276
Suffer from 'nerves'	1.71	3	2	4.4	0.00	1.0e+00	CRHR1 FNBP4 NFATC2IP
Overall health rating	1.78	3	2	4.4	0.00	1.0e+00	LOXL1-AS1 SCAI TMEM106C
Leg pain on walking	1.24	1	0	0.0	0.00	1.0e+00	WNT3
Knee pain experienced in last month	2.42	3	2	4.4	-1.00	3.7e-03	CEP250 TMEM106C UQCC
Hypertension (Self-reported)	1.95	11	6	13.3	-0.68	1.6e-02	DCAF16 FNBP4 JARID2 NCOA1 P4HA2-AS1 PDLIM4 SFXN2 SLC22A4 SLC22A5 SLC5A11 TNFSF12-TNFSF13
Illnesses of father: Heart disease	1.39	1	0	0.0	0.00	1.0e+00	DNAH10
Smoking status: Previous	1.93	1	0	0.0	0.00	1.0e+00	ADCY3
Forced expiratory volume in 1-second (FEV1), predicted	7.49	29	22	48.9	0.96	5.1e-20	ADCY3 AXIN2 C6orf106 CASKIN1 CD79B CDC14B CEP250 DCAF16 DLG5 DOT1L DYM GGT7 L3MBTL3 LOXL1-AS1 MMP24-AS1 NCOA1 P4HA2-AS1 PDLIM4 PIP4K2B RAD9A RP11-443B20.1 SCMH1 SLC22A4 SLC22A5 TP53I3 UQCC UQCC1 ZBTB38 ZCCHC24
Whole body fat-free mass	9.66	58	48	106.7	0.92	1.6e-26	ACTR1A ANKRD11 ARFGEF2 ARHGDIB AXIN2 BCKDHB BRD3 C6orf106 CASKIN1 CD79B CDC14B CDC42SE2 CEP192 CEP250 CRIPAK CRYL1 CYBRD1 CYP17A1-AS1 DCAF16 DLEU7 DLG5 DNAH10 DOC2A DOT1L DYM FAM45A FZD2 GGT7 HTR1D L3MBTL3 LOXL1-AS1 MAP1LC3A MMP24-AS1 NCOA1 NFATC2IP NUCKS1 P4HA2-AS1 PDLIM4 PIP4K2B PLCD3 PPP3R1 RAD9A RAPGEF6 RP11-250B2.6 SCMH1 SFXN2 SLC22A4 SLC22A5 SLC5A11 SLC9A3R2 SNUPN TFB1M TNFSF12-TNFSF13 TP53I3 UQCC UQCC1 ZBTB38 ZCCHC24
Leg fat-free mass (right)	8.18	54	40	88.9	0.90	3.8e-22	ACTR1A ADARB1 ANKRD11 ARFGEF2 AXIN2 C6orf106 CASKIN1 CD79B CDC14B CDC42SE2 CEP250 CRIPAK CYBRD1 CYP17A1-AS1 DCAF16 DLEU7 DLG5 DOC2A DOT1L DYM FAM45A FNBP4 FZD2 GGT7 HTR1D L3MBTL3 LOXL1-AS1 MAP1LC3A MMP24-AS1 NCOA1 NFATC2IP NUCKS1 P4HA2-AS1 PDLIM4 PIP4K2B PLCD3 PPP3R1 RAD9A RAPGEF6 RP11-250B2.6 SCAI SCMH1 SFXN2 SLC22A4 SLC22A5 SLC5A11 SLC9A3R2 TFB1M TNFSF12-TNFSF13 TP53I3 UQCC UQCC1 ZBTB38 ZCCHC24
Arm fat percentage (left)	5.37	20	16	35.6	-0.68	3.2e-04	ADARB1 ADCY3 ARFGEF2 BRD3 CD79B CENPO CEP192 DCAF16 DNAH10 DOC2A DPYSL4 FNBP4 FZD2 LOC100129961 NCOA1 NFATC2IP NOB1 RP11-443B20.1 SLC5A11 TNFSF12-TNFSF13
Handedness (chirality/laterality): Left-handed	1.57	2	2	4.4	0.00	1.0e+00	CRHR1 WNT3
Mood swings	1.83	4	2	4.4	-0.61	3.9e-01	CRHR1 FNBP4 NUCKS1 WNT3
Loneliness, isolation	1.66	2	0	0.0	0.00	1.0e+00	ARFGEF2 WNT3
Long-standing illness, disability or infirmity	1.67	1	0	0.0	0.00	1.0e+00	NOB1
Diabetes diagnosed by doctor	1.49	1	0	0.0	0.00	1.0e+00	NOB1
Qualifications: nursing, teaching	1.18	1	0	0.0	0.00	1.0e+00	AXIN2
Mouth/teeth dental problems: Mouth ulcers	1.69	2	2	4.4	0.00	1.0e+00	CRHR1 WNT3
Medication for cholesterol	1.36	1	0	0.0	0.00	1.0e+00	JARID2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.37	1	0	0.0	0.00	1.0e+00	ADAMTSL4
Asthma (self-reported)	2.50	6	5	11.1	-0.85	1.5e-02	HOXB2 KIF1B P4HA2-AS1 PDLIM4 SLC22A4 SLC22A5
Osteoarthritis (self-reported)	2.06	1	1	2.2	0.00	1.0e+00	TGFA
Smoking status: Current	1.58	3	1	2.2	0.00	1.0e+00	ACTR1A CYP17A1-AS1 SCAI
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.05	4	3	6.7	0.35	6.5e-01	CRHR1 NOB1 UQCC WNT3
Whole body water mass	9.60	57	49	108.9	0.92	2.0e-26	ACTR1A ANKRD11 ARFGEF2 ARHGDIB AXIN2 BCKDHB BRD3 C6orf106 CASKIN1 CCDC53 CD79B CDC14B CDC42SE2 CEP192 CEP250 CRIPAK CRYL1 CYBRD1 CYP17A1-AS1 DCAF16 DLEU7 DLG5 DNAH10 DOC2A DOT1L DYM FAM45A GGT7 HTR1D L3MBTL3 LOXL1-AS1 MAP1LC3A MMP24-AS1 NCOA1 NFATC2IP NUCKS1 P4HA2-AS1 PDLIM4 PIP4K2B PLCD3 PPP3R1 RAD9A RAPGEF6 RP11-250B2.6 SCMH1 SFXN2 SLC22A4 SLC22A5 SLC5A11 SLC9A3R2 SNUPN TNFSF12-TNFSF13 TP53I3 UQCC UQCC1 ZBTB38 ZCCHC24
Leg predicted mass (right)	8.20	54	40	88.9	0.90	3.5e-22	ACTR1A ADARB1 ANKRD11 ARFGEF2 AXIN2 C6orf106 CASKIN1 CD79B CDC14B CDC42SE2 CEP250 CRIPAK CYBRD1 CYP17A1-AS1 DCAF16 DLEU7 DLG5 DOC2A DOT1L DYM FAM45A FNBP4 FZD2 GGT7 HTR1D L3MBTL3 LOXL1-AS1 MAP1LC3A MMP24-AS1 NCOA1 NFATC2IP NUCKS1 P4HA2-AS1 PDLIM4 PIP4K2B PLCD3 PPP3R1 RAD9A RAPGEF6 RP11-250B2.6 SCAI SCMH1 SFXN2 SLC22A4 SLC22A5 SLC5A11 SLC9A3R2 TFB1M TNFSF12-TNFSF13 TP53I3 UQCC UQCC1 ZBTB38 ZCCHC24
Arm fat mass (left)	4.28	20	15	33.3	-0.17	4.5e-01	ADARB1 ADCY3 CASKIN1 CENPO DNAH10 DOC2A DPYSL4 FNBP4 FZD2 GGT7 L3MBTL3 LOC100129961 NFATC2IP NOB1 RAD9A RP11-443B20.1 SLC5A11 SLC9A3R2 UQCC ZBTB38
Number of self-reported non-cancer illnesses	1.65	2	0	0.0	0.00	1.0e+00	P4HA2-AS1 SLC22A5
Average weekly champagne plus white wine intake	1.45	2	0	0.0	0.00	1.0e+00	CRHR1 WNT3
Miserableness	1.89	4	3	6.7	-0.56	4.4e-01	CRHR1 FNBP4 LOXL1-AS1 WNT3
Guilty feelings	1.44	3	0	0.0	0.00	1.0e+00	CRHR1 FNBP4 WNT3
Financial situation satisfaction	1.20	1	0	0.0	0.00	1.0e+00	BRD3
Medication: Blood pressure	1.89	6	1	2.2	-0.75	5.4e-02	CRHR1 P4HA2-AS1 PDLIM4 SLC22A4 SLC22A5 TNFSF12-TNFSF13
High cholesterol (Self-reported)	0.97	2	0	0.0	0.00	1.0e+00	DCAF16 TMEM106C
Medication: Bendroflumethiazide	1.88	6	1	2.2	-0.78	3.9e-02	DOC2A P4HA2-AS1 PDLIM4 SLC22A4 SLC22A5 TNFSF12-TNFSF13
Medication: Paracetamol	1.76	2	2	4.4	0.00	1.0e+00	CRHR1 WNT3
Ever smoked	1.76	2	2	4.4	0.00	1.0e+00	ACTR1A CYP17A1-AS1
Basal metabolic rate	8.79	54	46	102.2	0.91	5.0e-24	ACTR1A ADARB1 ANKRD11 ARFGEF2 ARHGDIB AXIN2 C6orf106 CASKIN1 CD79B CDC14B CDC42SE2 CEP250 CRIPAK CYBRD1 CYP17A1-AS1 DCAF16 DLEU7 DLG5 DOC2A DOT1L DPYSL4 DYM FAM45A FZD2 GGT7 HTR1D L3MBTL3 LOXL1-AS1 MAP1LC3A MMP24-AS1 NCOA1 NFATC2IP NUCKS1 P4HA2-AS1 PDLIM4 PIP4K2B PLCD3 PPP3R1 RAD9A RAPGEF6 RP11-250B2.6 SCMH1 SFXN2 SLC22A4 SLC22A5 SLC5A11 SLC9A3R2 SNUPN TNFSF12-TNFSF13 TP53I3 UQCC UQCC1 ZBTB38 ZCCHC24
Leg fat percentage (left)	4.99	22	18	40.0	-0.67	1.7e-04	ADARB1 ADCY3 ARFGEF2 BRD3 CD79B CDC14B CENPO CEP192 CEP250 DCAF16 DNAH10 DOC2A DPYSL4 FNBP4 LOC100129961 NCOA1 NFATC2IP NOB1 RP11-443B20.1 SLC5A11 SLC9A3R2 UQCC
Arm fat-free mass (left)	8.88	56	45	100.0	0.92	2.7e-26	ACTR1A ADARB1 ANKRD11 ARFGEF2 ARHGDIB AXIN2 BRD3 C2CD3 C6orf106 CASKIN1 CD79B CDC14B CDC42SE2 CEP192 CEP250 CRIPAK CYBRD1 CYP17A1-AS1 DCAF16 DLEU7 DLG5 DNAH10 DOC2A DOT1L DYM FAM45A GGT7 HTR1D L3MBTL3 LOXL1-AS1 MAP1LC3A MMP24-AS1 NCOA1 NFATC2IP NUCKS1 P4HA2-AS1 PDLIM4 PLCD3 PPP3R1 RAD9A RAPGEF6 RP11-250B2.6 SCMH1 SFXN2 SLC22A4 SLC22A5 SLC5A11 SLC9A3R2 SNUPN TNFSF12-TNFSF13 TP53I3 TSC2 UQCC UQCC1 ZBTB38 ZCCHC24
Irritability	1.60	4	2	4.4	-0.98	1.7e-02	CRHR1 L3MBTL3 PPP1R21 WNT3
Ever had prostate specific antigen (PSA) test	1.44	1	0	0.0	0.00	1.0e+00	ZBTB38
Fractured/broken bones in last 5 years	2.15	3	0	0.0	0.00	1.0e+00	ARHGDIB C7orf58 WNT3
Diastolic blood pressure, automated reading	1.99	12	6	13.3	-0.05	8.7e-01	DCAF16 FNBP4 GIGYF1 LOC100129961 NCOA1 P4HA2-AS1 PDLIM4 SCMH1 SLC22A5 SLC5A11 SLC9A3R2 SRRT
Unable to work because of sickness or disability	1.48	1	0	0.0	0.00	1.0e+00	LOXL1-AS1
Vascular/heart problems diagnosed by doctor	1.80	9	3	6.7	0.84	2.4e-03	DCAF16 JARID2 P4HA2-AS1 PDLIM4 SFXN2 SLC22A4 SLC22A5 SLC5A11 TNFSF12-TNFSF13
Cholesterol lowering medication	1.24	2	0	0.0	0.00	1.0e+00	DCAF16 DNAH10
Pain experienced in last month	1.24	1	0	0.0	0.00	1.0e+00	SCAI
Alcohol drinker status: Previous	1.34	1	0	0.0	0.00	1.0e+00	ZNF276
Pack years of smoking	1.81	1	0	0.0	0.00	1.0e+00	CYB561
Impedance of whole body	2.88	26	17	37.8	-0.46	8.5e-03	ACTR1A ADCY3 ANKRD11 ARHGDIB CD79B CEP250 COPA CRHR1 CYBRD1 DLEU7 DNAH10 DOC2A KIF1B L3MBTL3 MAP1LC3A MMP24-AS1 NUCKS1 PLCD3 RAD9A RAPGEF6 RFT1 RP11-443B20.1 TMEM106C TNFSF12-TNFSF13 UQCC WNT3
Leg fat mass (left)	4.09	19	15	33.3	-0.18	4.3e-01	ACTR1A ADARB1 ADCY3 CASKIN1 CENPO DNAH10 DOC2A DPYSL4 FNBP4 GGT7 L3MBTL3 LOC100129961 NFATC2IP NOB1 RAD9A RP11-443B20.1 SLC5A11 SLC9A3R2 ZBTB38
Arm predicted mass (left)	8.93	59	45	100.0	0.92	1.5e-26	ACTR1A ADARB1 ANKRD11 ARFGEF2 ARHGDIB AXIN2 BCKDHB BRD3 C6orf106 CASKIN1 CD79B CDC14B CDC42SE2 CEP192 CEP250 CRIPAK CRYL1 CYBRD1 CYP17A1-AS1 DCAF16 DLEU7 DLG5 DNAH10 DOC2A DOT1L DYM FAM45A GGT7 HTR1D L3MBTL3 LOXL1-AS1 MAP1LC3A MMP24-AS1 NCOA1 NFATC2IP NUCKS1 P4HA2-AS1 PDLIM4 PIP4K2B PLCD3 POLD3 PPP3R1 RAD9A RAPGEF6 RP11-250B2.6 SCMH1 SFXN2 SLC22A4 SLC22A5 SLC5A11 SLC9A3R2 SNUPN TNFSF12-TNFSF13 TP53I3 UQCC UQCC1 ZBTB38 ZCCHC24 ZNF276

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Adipose Subcutaneous	38	1.09	2.8
GTEx	Adipose Visceral Omentum	19	0.93	2.9
GTEx	Adrenal Gland	15	1.03	2.8
GTEx	Artery Aorta	33	1.11	2.9
GTEx	Artery Coronary	17	1.44	2.9
GTEx	Artery Tibial	37	0.98	2.9
GTEx	Brain Caudate basal ganglia	14	1.52	2.9
GTEx	Brain Cerebellar Hemisphere	13	0.87	2.9
GTEx	Brain Cerebellum	20	1.01	2.8
GTEx	Brain Cortex	19	1.84	3.1
GTEx	Brain Frontal Cortex BA9	13	1.41	3.0
GTEx	Brain Hippocampus	7	1.34	3.1
GTEx	Brain Hypothalamus	7	1.19	2.9
GTEx	Brain Nucleus accumbens basal ganglia	12	1.39	3.3
GTEx	Brain Putamen basal ganglia	6	0.96	3.0
GTEx	Breast Mammary Tissue	21	1.06	2.9
GTEx	Breast Mammary Tissue (Male)	17	1.42	3.0
GTEx	Breast Mammary Tissue (Female)	20	1.22	2.7
GTEx	Cells EBV-transformed lymphocytes	23	1.62	3.0
GTEx	Cells Transformed fibroblasts	26	0.62	2.7
GTEx	Colon Sigmoid	14	0.96	2.7
GTEx	Colon Transverse	18	0.87	2.8
GTEx	Esophagus Gastroesophageal Junction	13	0.90	2.8
GTEx	Esophagus Mucosa	37	1.11	2.9
GTEx	Esophagus Muscularis	28	0.87	2.7
GTEx	Heart Atrial Appendage	15	0.95	2.9
GTEx	Heart Left Ventricle	11	0.72	2.6
GTEx	Liver	10	1.39	2.9
GTEx	Lung	28	0.97	2.9
GTEx	Muscle Skeletal	30	1.04	2.9
GTEx	Nerve Tibial	39	0.90	2.8
GTEx	Ovary	16	1.76	3.1
GTEx	Pancreas	14	0.86	2.7
GTEx	Pituitary	16	1.43	3.1
GTEx	Prostate	9	1.08	2.9
GTEx	Skin Not Sun Exposed Suprapubic	24	0.98	2.9
GTEx	Skin Sun Exposed Lower leg	38	1.04	3.0
GTEx	Small Intestine Terminal Ileum	8	1.74	2.9
GTEx	Spleen	16	1.13	3.0
GTEx	Stomach	17	1.17	2.9
GTEx	Testis	37	1.17	2.9
GTEx	Thyroid	38	0.95	2.7
GTEx	Uterus	9	1.59	3.1
GTEx	Vagina	7	1.10	3.0
GTEx	Whole Blood	25	1.25	2.9
METSIM	Adipose	29	0.63	2.5
NTR	Blood	17	0.71	2.6
ROSMAP	Brain Pre-frontal Cortex	28	0.64	2.7
YFS	Blood	31	0.67	2.5
CommonMind	Brain Pre-frontal Cortex	32	0.60	2.5
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	15	0.91	2.7
The Cancer Genome Atlas	Breast Invasive Carcinoma	30	0.68	2.5
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	11	1.00	2.7
The Cancer Genome Atlas	Colon Adenocarcinoma	16	0.77	2.6
The Cancer Genome Atlas	Esophageal Carcinoma	6	0.88	2.9
The Cancer Genome Atlas	Glioblastoma Multiforme	10	0.98	2.8
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	21	0.77	2.7
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	23	0.56	2.6
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	10	0.49	2.5
The Cancer Genome Atlas	Brain Lower Grade Glioma	27	0.63	2.6
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	12	1.08	2.8
The Cancer Genome Atlas	Lung Adenocarcinoma	17	0.58	2.5
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	15	0.60	2.6
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	15	0.94	2.8
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	11	0.66	2.7
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	8	0.60	2.6
The Cancer Genome Atlas	Prostate Adenocarcinoma	32	0.69	2.6
The Cancer Genome Atlas	Rectum Adenocarcinoma	6	0.87	2.7
The Cancer Genome Atlas	Soft Tissue Sarcoma	8	0.75	2.6
The Cancer Genome Atlas	Skin Cutaneous Melanoma	6	1.12	2.9
The Cancer Genome Atlas	Stomach Adenocarcinoma	11	0.65	2.6
The Cancer Genome Atlas	Testicular Germ Cell Tumors	16	1.25	2.6
The Cancer Genome Atlas	Thyroid Carcinoma	41	0.79	2.5
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	8	1.57	3.0