Best TWAS P=3.75e-09 · Best GWAS P=5.71e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | RP11-400F19.6 | 0.07 | 0.01 | lasso | 5 | 0.01 | 3.0e-02 | 5.8 | -5.9 | 3.7e-09 | -0.97 | 0.00 | 0.99 | TRUE |
| 2 | GTEx | Esophagus Mucosa | BECN1 | 0.24 | 0.08 | lasso | 4 | 0.05 | 5.1e-04 | 5.7 | 5.3 | 1.2e-07 | 0.80 | 0.01 | 0.98 | FALSE |
| 3 | GTEx | Esophagus Muscularis | NAGLU | 0.29 | 0.09 | lasso | 5 | 0.07 | 6.2e-05 | 5.7 | -5.7 | 1.1e-08 | -0.82 | 0.01 | 0.98 | FALSE |
| 4 | GTEx | Esophagus Muscularis | RP11-400F19.8 | 0.17 | 0.05 | lasso | 4 | 0.02 | 3.9e-02 | 5.7 | -5.8 | 5.7e-09 | -0.70 | 0.02 | 0.79 | FALSE |
| 5 | GTEx | Nerve Tibial | RP11-400F19.8 | 0.10 | 0.03 | lasso | 3 | 0.02 | 8.2e-03 | 5.7 | -5.5 | 2.9e-08 | -0.83 | 0.02 | 0.92 | FALSE |
| 6 | GTEx | Skin Not Sun Exposed Suprapubic | TUBG2 | 0.15 | 0.13 | lasso | 5 | 0.12 | 4.0e-07 | 5.8 | -5.8 | 6.2e-09 | -0.99 | 0.00 | 1.00 | FALSE |
| 7 | GTEx | Thyroid | RP5-882C2.2 | 0.10 | 0.07 | lasso | 3 | 0.07 | 2.9e-06 | 4.9 | -5.1 | 3.0e-07 | -0.08 | 0.05 | 0.94 | FALSE |
| 8 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | C17orf65 | 0.03 | 0.00 | blup | 37 | 0.01 | 2.3e-02 | 4.9 | -5.7 | 1.5e-08 | -0.09 | 0.03 | 0.79 | TRUE |
| 9 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ASB16 | 0.02 | 0.02 | blup | 39 | 0.02 | 3.8e-03 | 5.4 | -5.5 | 3.6e-08 | -0.09 | 0.02 | 0.50 | FALSE |
| 10 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C17orf65 | 0.03 | 0.01 | lasso | 10 | 0.02 | 3.6e-03 | 5.4 | -5.4 | 7.7e-08 | -0.09 | 0.02 | 0.90 | FALSE |
| 11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ASB16 | 0.02 | 0.03 | blup | 40 | 0.03 | 1.3e-04 | 4.7 | -5.2 | 1.6e-07 | -0.08 | 0.11 | 0.87 | FALSE |
| 12 | The Cancer Genome Atlas | Lung Adenocarcinoma | TUBG2 | 0.07 | 0.01 | enet | 7 | 0.02 | 2.2e-03 | 4.5 | -5.1 | 2.8e-07 | -0.80 | 0.00 | 0.25 | FALSE |
| 13 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ASB16 | 0.04 | 0.04 | lasso | 4 | 0.03 | 1.8e-04 | 5.4 | -5.4 | 8.5e-08 | -0.07 | 0.03 | 0.95 | FALSE |
| 14 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | C17orf65 | 0.07 | 0.02 | blup | 38 | 0.04 | 1.1e-02 | 4.8 | -5.4 | 5.2e-08 | -0.08 | 0.02 | 0.36 | FALSE |
| 15 | The Cancer Genome Atlas | Thyroid Carcinoma | C17orf65 | 0.03 | 0.03 | lasso | 7 | 0.03 | 3.8e-04 | 4.9 | -5.2 | 2.0e-07 | -0.07 | 0.05 | 0.86 | FALSE |