TWAS hub - ASB16

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1040	0.0490	3.7e-03	0.001	NA	0.011	NA	0.012	2.8e-01	NA	3.8e-02	NA	3.3e-02
2	GTEx	Cells Transformed fibroblasts	0.1370	0.0390	6.1e-07	0.141	NA	0.121	NA	0.122	9.5e-11	NA	2.3e-09	NA	2.0e-09
3	GTEx	Esophagus Mucosa	0.0980	0.0380	3.5e-04	0.101	NA	0.048	NA	0.076	3.1e-07	NA	3.9e-04	NA	8.2e-06
4	GTEx	Lung	0.0886	0.0355	3.9e-04	0.088	NA	0.072	NA	0.067	3.0e-07	NA	3.4e-06	NA	8.1e-06
5	GTEx	Muscle Skeletal	0.0684	0.0260	2.8e-04	0.060	NA	0.045	NA	0.057	1.7e-06	NA	3.0e-05	NA	2.9e-06
6	GTEx	Nerve Tibial	0.1217	0.0451	3.1e-05	0.074	NA	0.059	NA	0.073	6.3e-06	NA	5.4e-05	NA	7.5e-06
7	GTEx	Skin Sun Exposed Lower leg	0.1060	0.0410	1.1e-03	0.030	NA	0.024	NA	0.023	1.4e-03	NA	4.3e-03	NA	5.2e-03
8	GTEx	Testis	0.2400	0.0740	2.7e-04	0.021	NA	0.054	NA	0.041	3.9e-02	NA	2.0e-03	NA	6.3e-03
9	GTEx	Whole Blood	0.1060	0.0420	1.0e-03	0.027	NA	0.031	NA	0.020	1.5e-03	NA	6.3e-04	NA	5.5e-03
10	METSIM	Adipose	0.1095	0.0309	1.2e-09	0.021	0.069	0.075	0.07	0.073	3.3e-04	1.8e-10	2.8e-11	1e-10	4.2e-11
11	TCGA	Bladder Urothelial Carcinoma	0.0260	0.0200	9.3e-03	0.014	0.014	0.017	NA	0.014	2.1e-02	2.0e-02	1.2e-02	NA	2.0e-02
12	TCGA	Colon Adenocarcinoma	0.0460	0.0290	6.8e-04	0.059	0.054	0.042	NA	0.040	2.7e-04	4.6e-04	1.8e-03	NA	2.3e-03
13	TCGA	Head and Neck Squamous Cell Carcinoma	0.0215	0.0169	8.7e-03	0.015	0.018	0.005	NA	0.017	7.1e-03	3.8e-03	8.4e-02	NA	4.9e-03
14	TCGA	Kidney Renal Clear Cell Carcinoma	0.0246	0.0137	7.7e-05	0.030	0.032	0.030	NA	0.031	2.1e-04	1.3e-04	2.5e-04	NA	2.0e-04
15	TCGA	Brain Lower Grade Glioma	0.0296	0.0201	4.1e-04	0.031	0.023	0.007	NA	0.028	1.6e-04	1.0e-03	5.0e-02	NA	3.2e-04
16	TCGA	Lung Adenocarcinoma	0.0236	0.0156	3.2e-03	0.016	0.013	0.011	NA	0.015	5.2e-03	1.1e-02	1.8e-02	NA	6.3e-03
17	TCGA	Lung Squamous Cell Carcinoma	0.0402	0.0231	1.6e-04	0.042	0.028	0.025	NA	0.031	1.3e-05	3.1e-04	7.1e-04	NA	1.8e-04
18	TCGA	Thyroid Carcinoma	0.0660	0.0390	7.4e-04	0.012	0.025	0.021	NA	0.009	2.2e-02	1.6e-03	3.2e-03	NA	4.4e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Heel T-Score	23.7	188.3	256.0	-7.0	-16.0	-16.0	-13.7	15.0	-15.9	-9.6	-9.8	-13.2	-3.8	-14.9	-15.8	-13.3	-15.7	-15.7	-15.2	-15.1	-13.6
Heel bone mineral density (BMD) T-score, automated (left)	18.5	42.0	54.9	-5.0	-7.3	-7.3	-5.7	7.1	-7.3	-5.5	-4.7	-5.8	-3.6	-6.6	-7.4	-6.4	-7.3	-7.2	-7.2	-7.0	-6.5
Heel bone mineral density (BMD) T-score, automated (right)	14.5	33.2	45.0	-4.2	-6.6	-6.6	-5.0	6.5	-6.5	-4.5	-4.2	-5.1	-2.4	-5.9	-6.7	-5.6	-6.5	-6.3	-6.5	-6.4	-5.9
Fractured/broken bones in last 5 years	11.4	14.7	23.3	-0.3	4.4	4.4	3.4	-4.3	4.5	2.7	2.8	3.3	1.3	4.3	4.5	3.5	4.3	4.5	4.5	3.9	4.8
Trunk fat percentage	10.9	43.6	73.1	-3.5	-7.6	-7.6	-6.6	6.5	-7.3	-5.9	-5.0	-6.5	-2.5	-6.9	-7.5	-8.3	-7.7	-6.8	-6.8	-8.5	-3.4
Body fat percentage	10.2	40.2	65.3	-3.7	-7.2	-7.2	-6.2	6.2	-7.1	-5.7	-4.8	-6.4	-2.7	-6.4	-7.2	-8.0	-7.4	-6.7	-6.4	-8.1	-3.4
Supplements: Glucosamine	9.9	12.9	20.0	-1.5	-4.3	-4.3	-3.8	3.6	-4.3	-3.4	-2.3	-2.6	-1.3	-3.6	-4.1	-4.2	-4.5	-4.2	-3.7	-4.0	-2.6
Diverticular disease/diverticulitis (self-reported)	9.4	11.2	15.4	-2.3	-3.8	-3.8	-3.1	3.9	-3.8	-3.0	-2.8	-2.6	-1.2	-2.9	-3.9	-3.6	-3.9	-3.8	-3.8	-3.5	-3.2
Arm fat percentage (left)	9.0	35.8	56.1	-3.5	-6.8	-6.8	-5.9	5.9	-6.7	-5.3	-4.8	-5.8	-2.8	-5.9	-6.8	-7.4	-7.0	-6.4	-6.1	-7.5	-3.6
Arm fat percentage (right)	8.8	34.8	54.7	-3.7	-6.7	-6.7	-5.9	5.7	-6.6	-5.3	-4.6	-5.8	-2.7	-5.8	-6.7	-7.3	-6.9	-6.3	-6.0	-7.4	-3.6
Trunk fat mass	8.6	36.8	58.6	-3.1	-7.0	-7.0	-6.1	6.1	-6.8	-5.4	-4.9	-5.4	-2.3	-6.2	-7.0	-7.5	-7.1	-6.5	-6.3	-7.7	-3.8
Whole body fat mass	8.2	34.2	52.8	-3.0	-6.7	-6.7	-5.9	5.8	-6.6	-5.2	-4.7	-5.3	-2.5	-5.8	-6.7	-7.2	-6.9	-6.3	-6.1	-7.3	-3.8
Bipolar Disorder (2018)	7.2	11.3	19.8	1.2	-3.2	-3.1	-3.2	4.2	-3.6	-2.5	-1.6	-3.8	-1.9	-4.0	-3.6	-3.9	-4.1	-4.4	-4.1	-2.7	-3.0
Leg fat percentage (right)	6.9	25.0	41.0	-3.7	-5.6	-5.6	-4.7	4.6	-5.6	-4.3	-3.8	-5.3	-2.6	-4.8	-5.7	-6.4	-6.0	-5.4	-4.8	-6.3	-2.7
Arm fat mass (right)	6.7	27.6	41.2	-2.8	-5.9	-5.9	-5.3	5.2	-5.9	-4.8	-4.4	-4.7	-2.6	-5.0	-6.0	-6.4	-6.2	-5.8	-5.5	-6.3	-3.8
Arm fat mass (left)	6.7	27.5	40.9	-2.7	-5.9	-5.9	-5.2	5.3	-5.9	-4.7	-4.4	-4.6	-2.5	-5.0	-6.0	-6.4	-6.2	-5.8	-5.5	-6.3	-3.9
Leg fat percentage (left)	6.4	23.1	37.4	-3.5	-5.4	-5.4	-4.6	4.5	-5.4	-4.0	-3.7	-5.1	-2.3	-4.5	-5.5	-6.1	-5.7	-5.2	-4.7	-6.1	-2.7
Prospective memory result	6.1	7.4	9.9	0.9	-2.9	-2.9	-2.8	2.9	-3.1	-2.8	-2.6	-1.6	-1.9	-2.7	-3.0	-3.1	-3.1	-3.1	-3.0	-2.9	-2.6
Leg fat mass (right)	6.1	23.5	37.9	-2.9	-5.5	-5.5	-4.7	4.7	-5.4	-4.2	-4.1	-4.4	-2.3	-4.6	-5.5	-6.2	-5.8	-5.4	-5.0	-5.9	-3.1
Leg fat mass (left)	6.1	23.7	37.6	-2.8	-5.5	-5.5	-4.7	4.8	-5.5	-4.2	-4.1	-4.4	-2.2	-4.6	-5.6	-6.1	-5.8	-5.4	-5.0	-5.9	-3.3
Blood Platelet Count	6.0	69.6	88.2	-8.9	-8.8	-8.9	-9.0	8.8	-9.0	-8.9	-7.5	-9.4	-7.7	-7.7	-8.6	-6.8	-8.2	-7.9	-8.6	-7.7	-7.3
Osteoarthritis (self-reported)	5.2	6.7	12.5	0.8	-3.0	-3.0	-2.6	2.3	-3.2	-2.4	-1.6	-1.9	-1.7	-2.7	-2.9	-3.2	-3.5	-3.5	-2.4	-2.6	-1.8
Waist circumference	5.1	18.8	30.4	-2.3	-5.0	-4.9	-4.2	4.2	-4.9	-3.9	-3.6	-3.9	-1.9	-4.1	-5.0	-5.5	-5.2	-4.7	-4.4	-5.4	-2.7
Ever had prostate specific antigen (PSA) test	4.2	4.9	7.5	-0.2	-2.6	-2.6	-2.6	2.7	-2.5	-1.1	-1.5	-1.9	0.2	-2.1	-2.6	-2.7	-2.6	-2.5	-2.7	-2.3	-1.7
Supplements: Vitamin C	4.1	4.9	8.2	-0.7	-2.1	-2.1	-2.4	2.9	-2.3	-2.7	-1.7	-1.6	-2.4	-2.3	-2.2	-1.8	-2.5	-2.6	-2.7	-1.6	-2.1
Gout (self-reported)	3.9	5.4	7.8	-0.5	-2.4	-2.3	-2.1	2.6	-2.6	-1.9	-1.9	-2.7	-1.8	-2.6	-2.5	-2.8	-2.7	-2.6	-2.5	-2.6	-1.4
Hypothyroidism/myxoedema (self-reported)	3.9	7.7	10.3	1.7	3.0	3.1	3.1	-2.7	3.0	3.0	1.8	2.9	2.4	2.7	3.0	3.2	2.9	2.7	3.0	3.1	2.1
Schizophrenia vs Biploar Disorder	3.7	4.9	10.0	-0.5	2.1	2.1	2.7	-2.6	2.2	1.6	1.9	2.0	1.1	3.2	2.2	1.8	2.3	2.7	2.6	2.2	2.4
Crohns Disease (2012)	3.7	6.0	11.0	1.6	2.6	2.6	2.1	-2.3	2.6	1.9	2.5	1.9	1.7	2.6	2.7	3.3	3.0	2.9	2.3	3.0	1.5
Mouth/teeth dental problems: Dentures	3.6	6.0	8.8	2.5	2.8	2.9	2.3	-2.5	2.5	1.9	2.4	3.0	1.4	2.4	2.6	2.8	2.5	2.1	2.6	3.0	0.8
Bipolar Disorder (2011)	3.5	3.4	9.7	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-2.8	-2.8	-2.7	-3.1	-3.0	-3.1	-2.2	-2.1
Vitamin and mineral supplements	3.5	4.7	7.9	1.6	2.1	2.1	2.5	-2.8	2.3	2.7	1.3	0.9	2.1	1.7	2.3	2.1	2.5	2.4	2.6	1.7	2.2
Body mass index (BMI)	3.5	14.9	23.1	-2.3	-4.2	-4.2	-3.8	3.8	-4.4	-3.7	-3.6	-3.5	-2.5	-3.2	-4.3	-4.8	-4.7	-4.3	-3.9	-4.4	-2.9
BMI	3.4	19.5	32.6	-2.4	-4.8	-4.7	-4.1	4.6	-5.0	-4.5	-4.0	-3.7	-2.8	-3.7	-4.9	-5.7	-5.5	-5.1	-4.7	-4.6	-3.2
Handedness (chirality/laterality): Left-handed	3.4	4.1	5.2	-1.9	-2.3	-2.2	-2.0	2.3	-2.2	-2.1	-1.6	-1.6	-1.3	-2.2	-2.2	-1.8	-2.2	-2.2	-2.3	-1.8	-2.0
Bipolar Disorder or Schizophrenia	3.3	8.1	17.7	-0.4	-2.7	-2.7	-2.7	3.5	-2.8	-2.4	-1.1	-4.2	-1.8	-3.1	-3.0	-3.6	-3.4	-3.3	-3.4	-2.4	-1.4
Weight	3.3	16.2	25.2	-2.0	-4.6	-4.6	-4.0	4.0	-4.6	-3.6	-3.7	-2.6	-1.8	-3.7	-4.6	-5.0	-4.8	-4.6	-4.2	-4.8	-3.3
Average weekly champagne plus white wine intake	3.2	4.4	5.9	-1.8	-2.3	-2.3	-2.0	2.2	-2.4	-2.4	-1.7	-1.2	-2.3	-1.9	-2.2	-1.8	-2.2	-2.2	-2.3	-1.7	-2.2
Leg pain on walking	3.1	3.9	6.4	1.3	-2.0	-1.9	-1.2	2.0	-2.1	-2.1	-1.7	-2.0	-1.6	-2.1	-2.1	-2.2	-2.5	-2.5	-1.9	-2.3	-1.5
Maternal smoking around birth	3.0	4.3	6.3	-0.6	2.1	2.1	2.1	-2.5	2.2	2.4	1.5	0.9	2.1	2.1	2.3	2.5	2.3	2.3	2.5	1.8	1.8
Serious illness, injury or assault to yourself	3.0	3.6	6.0	-0.9	2.2	2.2	2.1	-1.9	2.1	1.2	1.7	1.2	1.1	2.0	2.2	1.7	1.9	2.0	2.1	2.3	2.4
Myopia	3.0	4.3	5.6	-1.4	-2.4	-2.4	-1.8	2.2	-2.2	-2.1	-1.7	-1.5	-1.7	-2.4	-2.3	-2.0	-2.1	-2.2	-2.4	-2.0	-2.0
Average weekly spirits intake	2.9	3.5	5.5	-1.0	-1.8	-1.7	-1.7	2.2	-1.9	-2.0	-1.5	-1.9	-1.7	-1.5	-2.0	-2.1	-2.3	-2.4	-2.1	-1.5	-2.0
Hair/balding pattern: Pattern 4	2.9	7.0	12.8	0.4	3.0	3.0	2.1	-3.6	2.8	1.4	2.0	3.0	1.6	3.1	3.0	2.5	2.7	2.7	3.5	2.5	2.8
Supplements: Fish oil (including cod liver oil)	2.8	3.6	5.5	-0.4	-2.1	-2.1	-2.2	2.3	-2.1	-1.6	-1.2	-1.0	-0.8	-1.9	-2.2	-2.0	-2.1	-2.2	-2.3	-1.9	-2.2
Osteoporosis (self-reported)	2.7	3.4	5.6	0.1	2.0	2.0	1.6	-2.3	2.1	1.5	0.2	1.3	0.6	1.9	2.2	2.2	2.4	2.3	2.3	1.9	1.6
Coronary Artery Disease (CAD)	2.6	3.1	4.8	0.7	2.2	1.8	1.8	-1.6	2.0	1.6	1.5	1.9	1.8	1.9	1.9	1.6	1.9	1.9	1.7	1.8	1.6
Primary Biliary Cirrhosis	2.6	3.7	5.4	-0.6	-2.3	-2.3	-1.9	2.0	-2.1	-1.6	-1.3	-2.1	-0.7	-2.3	-2.2	-2.0	-2.1	-2.2	-2.0	-2.3	-1.4
Peak expiratory flow (PEF)	2.6	6.0	11.7	0.5	2.4	2.3	2.5	-2.5	2.5	2.6	1.8	3.4	2.5	2.8	2.5	2.2	2.5	2.6	2.5	2.5	2.3
Eye problems/disorders: Diabetes related eye disease	2.5	2.8	9.2	1.2	1.6	1.6	1.3	-1.4	1.4	1.7	3.0	1.4	1.9	1.6	1.6	2.0	1.4	1.2	1.5	2.2	0.5
Hip circumference	2.5	10.6	20.1	-1.1	-3.8	-3.8	-3.4	3.1	-3.7	-2.9	-3.1	-2.0	-1.3	-2.8	-3.7	-4.5	-4.0	-3.7	-3.3	-4.0	-2.0
Pulse wave reflection index	2.5	3.1	6.1	0.1	2.0	2.0	1.7	-1.7	2.0	1.1	0.9	2.1	0.3	2.2	2.0	2.2	2.0	1.8	1.8	2.5	1.1
Chronic bronchitis/emphysema (mother)	2.5	2.9	9.0	1.9	2.0	2.0	1.7	-1.4	1.8	1.3	3.0	1.9	0.5	2.0	1.7	1.3	1.4	1.3	1.5	1.8	0.8
Pulse wave peak to peak time	2.4	2.9	5.0	1.2	-1.8	-1.8	-1.6	2.1	-1.8	-1.3	-1.4	-0.4	-0.7	-2.0	-1.9	-2.2	-2.1	-2.0	-2.0	-1.8	-0.9
Knee pain experienced in last month	2.4	3.8	6.5	-1.7	-2.4	-2.4	-1.9	1.7	-2.3	-1.7	-1.7	-1.5	0.3	-2.1	-2.2	-2.4	-2.3	-1.8	-1.8	-2.6	-0.2
Guilty feelings	2.4	3.6	10.6	-1.3	-1.6	-1.6	-1.2	1.6	-1.7	-3.3	-1.7	-3.2	-3.0	-1.3	-1.7	-1.8	-1.6	-1.4	-1.7	-1.3	-1.1
Shortness of breath walking on level ground	2.3	2.7	5.4	0.2	-1.6	-1.6	-1.2	1.6	-1.6	-1.4	-2.0	-1.2	-1.3	-2.2	-1.8	-1.8	-1.8	-1.8	-1.6	-2.3	-1.3
Qualifications: None of the above	2.2	4.6	12.5	3.5	1.9	1.9	2.3	-1.7	1.8	2.4	2.8	2.6	2.7	2.3	1.7	1.9	1.8	1.7	1.7	1.9	0.2
Pulse wave Arterial Stiffness index	2.2	2.5	4.7	-1.2	1.6	1.6	1.5	-2.0	1.7	1.3	1.3	0.3	0.9	1.9	1.8	2.2	2.0	1.9	1.9	1.7	0.8
Family relationship satisfaction	2.2	2.7	4.2	0.8	1.8	1.8	1.8	-1.8	1.9	1.3	1.8	1.7	1.1	2.0	1.7	1.1	1.5	1.8	1.9	1.5	2.1
Crohns Disease (2017)	2.1	4.7	11.3	1.5	2.3	2.3	1.8	-2.2	2.3	1.5	1.8	0.6	0.6	2.8	2.4	3.4	2.7	2.5	2.2	3.0	0.3
Sitting height	2.1	14.6	28.2	0.4	4.0	3.9	3.7	-3.7	4.0	3.6	3.4	5.3	3.3	3.6	4.1	5.3	4.4	3.5	3.8	4.6	0.6
Mineral and other dietary supplements	2.1	2.9	4.2	0.9	2.0	1.9	1.9	-1.8	1.9	1.6	1.3	0.9	0.6	1.5	2.0	1.8	2.1	2.0	1.8	1.9	1.7
Medication: Paracetamol	2.0	3.4	7.1	-0.3	-1.7	-1.7	-1.3	2.1	-2.0	-2.7	-1.6	-1.7	-2.3	-1.2	-2.0	-2.1	-2.3	-2.1	-2.0	-1.4	-1.2
Hypothyroidism (self reported)	1.9	4.3	7.5	1.6	2.5	2.5	2.3	-1.7	2.3	2.1	0.8	1.9	1.4	2.1	2.4	2.5	2.1	1.9	2.1	2.7	1.5
Age when periods started (menarche)	1.9	4.5	7.8	1.4	2.4	2.4	2.8	-2.6	2.5	1.8	0.5	1.1	0.8	2.2	2.4	1.5	2.3	2.4	2.5	1.9	2.8
Medication: Levothyroxine sodium	1.9	3.3	6.1	1.2	2.0	2.0	2.0	-1.6	2.0	2.1	0.9	2.0	1.3	1.5	2.1	2.5	2.0	1.7	1.8	2.3	1.2
Mean Putamen Volume	1.8	2.0	4.1	-0.6	1.5	1.5	1.7	-2.0	1.4	-0.3	1.2	1.0	-0.2	1.6	1.5	1.3	1.4	1.6	2.0	1.3	2.0
Chronic bronchitis/emphysema (father)	1.8	2.1	4.9	0.5	1.4	1.4	1.0	-1.3	1.5	1.7	1.7	1.4	2.0	0.8	1.6	2.2	1.7	1.3	1.5	1.3	0.6
Impedance of arm (right)	1.8	8.2	19.9	-2.2	-3.3	-3.4	-3.0	2.5	-2.8	-2.3	-1.2	-3.6	-0.1	-4.2	-3.1	-3.2	-2.7	-2.1	-2.7	-4.5	0.4
Heart disease (mother)	1.8	2.1	4.3	0.6	1.8	1.8	1.8	-1.5	1.6	0.7	1.0	0.2	0.8	1.4	1.7	2.1	1.7	1.6	1.8	1.5	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	5.2	-0.3	-1.8	-1.8	-1.4	0.6	-1.8	-1.7	-2.0	-2.3	-0.9	-0.7	-1.5	-1.4	-1.5	-1.2	-0.8	-1.6	-0.5
Ever taken oral contraceptive pill	1.8	2.0	3.8	-1.1	1.4	1.4	1.4	-1.0	1.5	1.2	1.3	1.9	1.2	1.5	1.5	1.2	1.4	1.6	1.2	1.7	1.6
Medication: Paracetamol	1.8	2.8	5.4	0.3	-1.8	-1.8	-1.4	1.8	-1.9	-2.3	-1.8	-1.4	-1.7	-1.2	-1.9	-1.9	-2.0	-1.7	-1.7	-1.5	-0.9
Cholesterol lowering medication	1.8	2.7	4.0	-0.9	-1.8	-1.8	-1.5	2.0	-2.0	-1.5	-0.9	-2.0	-1.1	-1.8	-1.8	-1.3	-1.9	-1.9	-1.9	-1.7	-1.3
Bilateral oophorectomy (both ovaries removed)	1.7	1.9	3.3	-0.7	-1.6	-1.6	-1.7	1.5	-1.8	-0.7	0.0	-1.8	0.0	-1.0	-1.6	-1.5	-1.6	-1.6	-1.5	-1.4	-1.2
Impedance of arm (left)	1.7	8.0	19.1	-1.8	-3.2	-3.4	-2.8	2.6	-2.8	-2.2	-1.2	-3.4	-0.1	-4.1	-3.1	-3.3	-2.7	-2.2	-2.8	-4.4	0.2
Glaucoma (self-reported)	1.7	2.1	5.2	-0.2	-1.5	-1.5	-1.6	1.2	-1.5	0.3	-2.2	-1.3	-0.1	-2.3	-1.3	-0.6	-1.2	-1.7	-1.3	-1.4	-1.9
Diastolic blood pressure, automated reading	1.7	5.1	11.0	-0.3	2.5	2.5	2.2	-2.8	2.6	2.0	1.8	0.8	1.5	3.3	2.4	1.6	2.4	2.7	2.8	2.1	2.3
Multivitamins +/- minerals	1.6	2.0	4.6	-2.1	-1.4	-1.4	-1.7	1.3	-1.5	-1.5	-1.1	-1.1	-1.0	-1.1	-1.5	-1.5	-1.5	-1.3	-1.3	-1.6	-1.4
Qualifications: A levels/AS levels or equivalent	1.6	3.5	6.0	-1.5	-2.0	-2.1	-1.5	1.5	-1.9	-2.4	-2.4	-2.1	-2.4	-1.9	-1.9	-2.1	-1.8	-1.7	-1.7	-1.7	-0.7
Qualifications: nursing, teaching	1.6	2.5	6.7	-1.1	-1.2	-1.3	-1.5	1.1	-1.3	-1.3	-2.6	-2.1	-1.8	-1.8	-1.3	-2.1	-1.5	-1.3	-1.2	-1.8	0.3
Basal cell carcinoma (self-reported)	1.6	1.9	4.9	-1.8	-1.5	-1.5	-1.6	1.2	-1.4	-1.0	-0.7	-2.2	-0.6	-1.1	-1.4	-2.0	-1.6	-1.4	-1.3	-1.1	-0.5
Other serious medical condition/disability diagnosed by doctor	1.5	1.9	3.9	0.6	1.6	1.7	2.0	-1.2	1.5	1.3	0.5	1.5	1.7	1.5	1.4	1.2	1.1	1.1	1.5	1.4	1.4
Medication for hormone replacement therapy	1.5	1.7	3.7	0.4	-1.4	-1.5	-1.9	1.4	-1.2	-0.9	-1.3	-1.9	0.8	-1.7	-1.3	-1.2	-1.2	-1.1	-1.4	-1.3	-0.4
Alcohol usually taken with meals	1.5	2.4	8.5	-2.9	-1.6	-1.6	-1.8	1.6	-1.5	-1.4	-1.9	-0.7	-1.2	-1.9	-1.3	-0.2	-1.1	-1.3	-1.5	-1.2	-1.8
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	5.8	1.3	1.5	1.5	1.9	-1.1	1.2	1.8	0.5	0.0	1.1	1.3	1.5	2.4	1.6	1.2	1.2	2.0	-0.4
Medication: Allopurinol	1.5	2.1	4.7	-0.6	-1.6	-1.6	-0.8	1.7	-1.7	-1.0	-0.6	-1.1	-0.5	-1.4	-1.7	-2.2	-1.9	-1.6	-1.6	-1.9	-0.5
Medication: Seretide 50 evohaler	1.5	1.7	3.4	-0.9	-1.5	-1.5	-1.4	1.2	-1.4	-1.3	-0.7	-1.8	-0.9	-0.9	-1.5	-1.6	-1.3	-1.0	-1.3	-1.7	-0.8
Tinnitus: Yes, now most or all of the time	1.5	1.7	6.0	-0.5	-1.2	-1.2	-0.6	1.2	-1.3	-1.2	-2.1	-2.4	-0.1	-1.1	-1.3	-1.4	-1.5	-1.2	-1.1	-1.6	-0.3
Depressed Affect (Nagel 2018)	1.4	3.0	6.8	-0.1	2.0	1.9	1.1	-1.5	2.1	1.2	0.7	0.9	1.1	2.1	2.0	2.6	2.2	2.2	1.8	2.3	0.8
Waist Hip Ratio (WHR)	1.4	6.4	17.6	-1.4	-2.9	-3.0	-2.4	1.9	-2.9	-1.9	-0.8	-4.2	-1.3	-2.6	-2.9	-2.8	-2.8	-2.4	-2.1	-3.4	-1.2
Type 2 Diabetes (T2D) (2018)	1.4	2.6	10.7	-0.5	1.5	1.6	1.4	-1.7	1.2	1.3	3.3	2.0	1.2	2.1	1.4	1.6	1.1	1.0	1.7	1.6	0.9
Severe depression (siblings)	1.4	1.6	4.2	-0.3	-1.0	-0.9	-0.5	1.2	-1.2	-1.7	-1.0	-1.7	-1.4	-1.3	-1.2	-2.1	-1.6	-1.4	-1.2	-1.3	0.1
Number of operations (self-reported)	1.4	2.1	3.8	0.1	-1.8	-1.8	-1.7	1.6	-1.8	-0.5	-1.5	-1.3	-0.4	-1.0	-1.7	-1.5	-1.6	-1.6	-1.7	-1.2	-1.9
Blood Red Count	1.3	12.8	22.8	1.3	4.2	4.3	3.4	-4.6	4.0	3.2	3.3	2.4	0.8	4.8	4.0	1.8	3.3	3.7	4.4	3.4	4.5
Pain all over the body in last month	1.3	1.4	3.4	1.8	1.2	1.2	1.4	-0.9	1.4	1.3	0.5	0.8	0.7	1.1	1.3	1.0	1.3	1.3	1.0	1.4	0.7
Pulse rate	1.3	2.2	3.6	0.1	1.8	1.8	1.9	-1.7	1.6	1.9	1.0	0.3	1.8	1.3	1.6	1.3	1.5	1.5	1.8	0.9	1.5
Ever had bowel cancer screening	1.3	1.6	3.1	0.5	-1.2	-1.2	-1.8	0.9	-1.2	-1.0	-1.7	-1.7	0.4	-1.6	-1.2	-1.2	-1.4	-1.4	-1.0	-1.3	-0.9
Ever smoked	1.3	2.2	8.2	-2.0	-0.9	-0.9	-1.2	1.1	-1.1	-2.4	-1.4	-1.1	-2.9	-1.3	-1.1	-0.8	-1.1	-1.3	-1.2	-0.9	-1.9
Prostate Cancer	1.2	1.7	6.0	-1.8	-1.2	-1.2	-0.9	1.2	-1.3	-1.2	-1.4	0.2	-1.8	-1.4	-1.2	-0.4	-0.9	-1.2	-1.3	-1.0	-2.5
Schizophrenia (2014)	1.2	2.6	7.3	-0.6	-1.5	-1.5	-1.4	1.8	-1.5	-1.4	-0.0	-2.7	-1.1	-1.1	-1.7	-2.6	-2.1	-1.7	-1.8	-1.6	-0.2
Asthma	1.2	2.4	5.8	-0.9	-1.8	-1.8	-1.4	1.7	-1.6	-1.4	-1.8	-2.4	-1.2	-1.6	-1.6	-1.0	-1.5	-1.5	-1.6	-1.4	-1.3
Depression (self-reported)	1.2	1.5	3.6	-0.4	-1.3	-1.2	-1.6	1.2	-1.3	-1.1	-1.9	-1.5	-0.6	-1.1	-1.2	-1.1	-1.1	-0.9	-1.3	-1.0	-0.9
Loud music exposure frequency	1.2	1.4	2.2	0.9	1.4	1.4	0.9	-1.3	1.3	1.3	0.7	0.5	1.5	1.0	1.3	1.2	1.2	1.2	1.4	0.8	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	4.1	-0.1	1.5	1.5	1.3	-1.2	1.4	0.9	0.5	1.1	-0.4	1.2	1.3	2.0	1.4	1.0	1.3	1.4	-0.1
Pulse rate, automated reading	1.2	3.7	5.9	0.7	2.3	2.3	2.2	-2.2	2.1	2.3	1.5	0.0	2.4	2.0	2.1	1.1	1.6	1.8	2.2	1.6	2.4
Loneliness, isolation	1.2	1.7	5.1	-0.4	1.4	1.4	1.1	-1.4	1.4	0.1	-0.4	0.2	-0.7	1.4	1.5	2.3	1.6	1.5	1.6	1.9	0.7
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	7.5	-0.8	-1.4	-1.4	-1.0	1.1	-1.6	-0.8	-1.3	-2.7	-0.7	-1.0	-1.4	-1.9	-1.6	-1.3	-1.1	-1.7	-0.7
Medication: Omeprazole (e.g. Zanprol)	1.2	1.4	6.9	-2.6	-0.9	-0.9	-0.6	0.2	-1.1	-1.8	-1.5	-2.0	-1.2	-0.0	-0.9	-1.2	-1.0	-0.6	-0.3	-0.8	0.2
Alzheimer’s Disease (including proxy)	1.1	1.7	4.6	-0.8	-1.3	-1.2	-1.3	1.5	-1.2	-1.6	-0.4	0.1	-1.1	-0.1	-1.5	-2.1	-1.7	-1.4	-1.5	-1.4	-0.6
LDL Cholesterol	1.1	1.7	4.6	1.2	1.2	1.3	1.3	-1.3	1.4	1.1	1.1	0.2	-0.7	1.7	1.4	0.5	1.3	1.6	1.4	1.2	2.1
Ulcerative Colitis	1.1	1.6	3.0	0.3	1.1	1.1	1.2	-1.5	1.4	1.2	1.0	1.2	1.5	1.4	1.3	1.7	1.6	1.5	1.4	1.2	0.7
Diabetes (mother)	1.1	1.4	2.4	-0.6	1.3	1.4	1.2	-1.1	1.1	1.2	-0.2	0.1	1.4	1.5	1.3	1.1	1.1	1.3	1.3	1.5	1.5
Diabetes (self-reported)	1.1	1.7	4.9	-0.8	1.1	1.1	1.7	-1.2	0.9	1.2	2.2	1.5	1.9	1.5	1.1	1.6	0.9	0.7	1.3	1.4	0.2
Lung cancer (father)	1.1	1.2	3.5	1.4	-1.2	-1.1	-1.1	1.0	-1.3	-0.3	-0.0	0.2	-0.2	-1.2	-1.2	-1.0	-1.3	-1.6	-1.1	-0.8	-1.9
Diabetes diagnosed by doctor	1.1	1.8	5.8	-0.9	1.2	1.3	1.7	-1.2	1.0	1.3	2.4	1.7	1.6	1.3	1.1	1.5	0.9	0.6	1.3	1.4	0.2
Asthma (self-reported)	1.1	2.3	5.6	-0.9	-1.7	-1.7	-1.3	1.6	-1.6	-1.4	-1.7	-2.4	-1.4	-1.5	-1.5	-0.9	-1.4	-1.4	-1.5	-1.3	-1.4
Mother’s age at death	1.1	1.3	3.1	-0.5	-1.2	-1.2	-0.9	0.9	-1.1	-1.2	-1.1	-0.9	-1.6	-0.5	-1.3	-1.7	-1.3	-1.2	-1.0	-1.4	-1.1
Medication: Bendroflumethiazide	1.1	1.6	3.3	-1.8	1.4	1.4	1.8	-0.9	1.4	0.3	1.6	1.1	-0.2	1.2	1.2	1.0	1.2	1.3	1.1	1.2	1.5
Age at First Birth	1.0	1.4	5.3	-1.9	-1.2	-1.1	-0.8	0.9	-1.0	-1.0	-2.3	-0.6	-1.4	-1.3	-1.1	-0.8	-0.9	-1.0	-1.0	-1.2	-0.9
Supplements: Zinc	1.0	1.0	6.2	-1.2	-0.4	-0.3	-0.3	1.2	-0.5	-1.4	-1.1	-1.2	-2.5	-0.9	-0.6	-0.7	-0.6	-0.7	-1.0	-0.6	-0.6
Hearing difficulty/problems with background noise	1.0	1.5	2.9	-0.3	1.3	1.4	1.7	-1.7	1.4	0.8	1.3	0.7	0.0	1.6	1.3	0.9	1.2	1.4	1.7	0.4	1.5
Happiness	1.0	1.2	2.3	-0.9	1.2	1.2	1.0	-1.0	1.3	0.2	1.2	0.9	-0.3	1.3	1.2	1.5	1.4	1.4	1.1	1.2	0.5
Birth weight of first child	1.0	1.8	3.2	1.0	-1.3	-1.4	-1.8	1.8	-1.3	-1.2	-1.5	-1.0	-0.2	-1.2	-1.4	-1.2	-1.3	-1.3	-1.8	-1.1	-1.6
Emphysema/chronic bronchitis	1.0	1.2	3.6	1.9	-0.9	-0.9	-1.4	1.2	-1.0	-1.8	-0.5	-1.0	-0.3	-1.0	-1.0	-0.2	-0.9	-0.9	-1.0	-0.7	-1.3
Comparative height size at age 10	1.0	5.4	10.9	0.6	-2.9	-2.9	-2.8	2.2	-2.4	-0.4	-1.5	0.3	2.1	-3.1	-2.5	-3.3	-2.6	-2.4	-2.4	-3.0	-0.5
Commuting to job workplace: Public transport	1.0	1.2	3.8	-0.5	-1.3	-1.3	-0.9	1.0	-1.2	-1.4	-0.3	-0.5	-1.3	-1.9	-1.1	-0.9	-1.0	-1.2	-1.2	-0.9	-0.9
Impedance of whole body	1.0	5.1	14.1	-1.3	-2.6	-2.7	-2.0	1.8	-2.2	-1.4	-0.3	-3.6	0.2	-3.3	-2.4	-2.8	-2.0	-1.4	-2.0	-3.8	0.8
Depression (Nagel 2018)	0.9	1.3	3.5	0.2	1.3	1.2	0.9	-0.9	1.3	0.4	0.2	-0.4	0.5	1.9	1.2	1.4	1.4	1.6	1.1	1.7	1.0
Ovarian Cancer	0.9	1.2	3.1	-0.3	1.2	1.2	1.3	-0.8	1.1	1.3	-0.1	1.8	1.3	1.1	1.0	1.4	1.2	1.0	0.8	1.1	0.3
Blood White Count	0.9	6.4	16.9	-3.0	-2.5	-2.4	-1.1	1.8	-2.8	-1.9	0.3	-3.4	-3.8	-1.3	-2.7	-2.1	-2.2	-2.5	-2.3	-2.3	-4.1
Sensitivity / hurt feelings	0.9	1.5	8.3	-2.2	-0.3	-0.3	-0.8	0.5	-0.6	-1.9	-2.2	-0.8	-2.9	-0.3	-0.4	-0.1	-0.6	-0.9	-0.4	0.2	-1.3
Frequency of depressed mood in last 2 weeks	0.9	1.3	3.2	0.6	1.2	1.2	1.4	-0.7	1.3	-0.1	0.1	-0.9	-0.8	1.8	1.1	1.3	1.3	1.5	0.9	1.7	0.8
Medication: Metformin	0.9	1.2	8.0	0.3	0.6	0.6	0.8	-0.4	0.4	1.5	2.8	1.4	2.3	0.6	0.5	0.8	0.3	0.1	0.5	0.8	-0.1
Townsend deprivation index at recruitment	0.9	1.2	2.3	0.9	1.3	1.3	1.4	-1.5	1.0	0.5	1.0	0.1	0.1	0.5	1.3	1.5	1.1	1.0	1.4	1.5	1.0
Average weekly fortified wine intake	0.9	1.0	2.8	-1.0	-0.6	-0.6	-0.7	1.3	-0.7	-1.6	-1.7	-1.5	-1.6	-0.9	-0.8	-0.5	-0.6	-0.4	-1.0	-0.8	-0.4
Fed-up feelings	0.9	1.6	3.3	0.7	1.4	1.4	0.8	-1.4	1.5	0.8	0.7	0.1	0.7	1.5	1.5	1.6	1.7	1.8	1.4	1.4	1.2
Illnesses of siblings	0.9	1.2	6.5	-1.3	-0.6	-0.6	-0.5	0.9	-0.7	-1.3	-1.7	-1.1	-2.5	-0.9	-0.7	-0.9	-1.0	-1.1	-1.0	-0.3	-0.6
Friendships satisfaction	0.9	1.1	2.6	-1.3	1.0	1.0	1.1	-1.2	1.2	0.4	0.7	0.4	-0.4	1.1	1.1	0.6	1.2	1.4	1.2	0.7	1.6
Hearing aid user	0.9	1.0	1.6	-0.6	-1.1	-1.2	-0.8	1.3	-0.9	-1.0	-0.7	-0.9	-0.2	-1.0	-1.2	-1.2	-1.1	-0.8	-1.3	-1.3	-0.4
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.1	0.5	-1.2	-1.2	-1.4	0.9	-1.1	-0.9	0.2	-0.9	-0.5	-0.9	-1.1	-1.3	-1.0	-0.8	-1.0	-1.4	-0.5
Diabetes (father)	0.8	1.0	4.6	-0.4	-1.0	-1.0	-1.5	0.6	-0.8	0.2	-1.3	-0.5	2.1	-1.0	-0.7	-1.0	-0.7	-0.3	-0.6	-1.0	1.1
Leg predicted mass (left)	0.8	4.0	6.6	-0.6	-2.2	-2.2	-2.0	2.1	-2.1	-2.1	-2.6	0.4	-1.0	-1.5	-2.2	-2.2	-2.2	-2.3	-2.2	-1.9	-2.4
Mouth/teeth dental problems	0.8	1.3	2.9	-1.0	-1.2	-1.2	-1.1	1.7	-1.1	-1.1	-0.7	-0.8	-0.5	-1.0	-1.3	-1.5	-1.3	-1.1	-1.6	-1.0	-0.2
Number of live births	0.8	1.1	3.2	-0.5	1.2	1.3	1.0	-0.5	0.9	0.3	0.5	1.8	-1.4	1.3	1.0	1.5	0.9	0.5	0.7	1.4	-0.8
Length of working week for main job	0.8	0.9	3.7	1.9	-0.6	-0.6	-0.6	1.0	-0.7	-0.2	-0.8	-1.0	-0.7	-1.3	-0.6	0.0	-0.4	-0.9	-1.0	-0.5	-1.8
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	6.6	-1.4	-0.9	-0.9	-0.6	0.2	-0.9	-1.4	-1.4	-2.6	-1.7	-0.4	-0.8	-0.8	-0.9	-0.7	-0.4	-0.7	-0.5
Number of full brothers	0.8	1.0	8.9	3.0	0.3	0.3	0.5	-0.9	0.4	1.2	0.4	1.2	1.8	0.7	0.4	0.1	0.3	0.5	0.8	0.2	0.5
Health satisfaction	0.8	1.0	1.7	1.2	1.1	1.2	1.1	-1.2	1.2	1.1	0.5	0.6	1.1	0.8	1.1	1.3	1.1	0.9	1.2	1.0	0.2
Medication: Ibuprofen	0.8	0.9	2.4	0.7	0.8	0.8	0.9	-0.8	1.0	0.5	0.6	0.8	0.2	1.5	1.0	0.7	1.1	1.5	0.9	1.0	1.4
Medication: Omeprazole	0.8	0.9	5.9	-2.4	-0.6	-0.6	0.0	-0.2	-0.7	-1.6	-0.9	-1.3	-1.2	0.5	-0.6	-1.0	-0.7	-0.2	0.1	-0.5	0.7
Mean time to correctly identify matches	0.8	1.6	2.8	-0.9	1.5	1.5	0.9	-1.7	1.3	0.7	0.4	1.6	0.4	1.1	1.4	1.6	1.5	1.4	1.6	1.2	0.6
Illnesses of father: Heart disease	0.8	1.0	5.8	0.4	0.5	0.4	-0.4	-0.9	0.9	1.5	-0.1	-1.4	1.4	-0.5	0.8	0.3	1.0	1.4	0.9	-0.3	2.4
Commuting to job workplace: Walk	0.8	0.9	2.0	1.4	0.9	0.9	1.0	-0.7	0.9	1.2	0.7	-0.5	0.4	0.6	1.0	1.3	1.1	0.9	0.7	1.4	0.4
Medication for cholesterol	0.8	1.2	3.4	0.1	1.4	1.4	0.7	-1.0	1.3	0.9	-0.2	1.9	-0.0	1.0	1.3	1.4	1.2	0.9	1.1	1.6	0.5
Irritable Bowel Disease (IBD)	0.7	1.6	4.4	1.1	1.2	1.1	0.8	-1.4	1.4	1.0	1.0	0.3	0.5	1.6	1.3	2.1	1.7	1.6	1.3	1.6	-0.1
Allergy or Eczema	0.7	1.8	6.7	-0.3	1.5	1.6	1.0	-0.8	1.4	0.7	1.0	0.2	-0.1	1.7	1.5	2.6	1.6	1.1	1.1	2.3	-0.7
Leg fat-free mass (left)	0.7	3.8	6.3	-0.5	-2.2	-2.2	-2.0	2.0	-2.1	-2.0	-2.5	0.4	-0.9	-1.5	-2.1	-2.2	-2.2	-2.3	-2.1	-1.9	-2.3
Number of incorrect matches in round	0.7	1.1	5.6	1.5	0.9	1.0	0.9	-0.5	0.6	1.4	1.3	2.4	0.9	0.7	0.8	0.6	0.4	0.1	0.6	1.5	-0.3
Past tobacco smoking	0.7	1.2	4.1	1.7	0.8	0.8	1.1	-0.7	0.9	2.0	0.9	1.0	1.8	0.8	0.9	0.7	0.8	0.9	0.8	0.6	1.3
Nervous feelings	0.7	1.3	3.7	-0.5	-1.3	-1.3	-0.9	1.1	-1.2	-1.4	-1.1	-1.9	-1.1	-0.9	-1.1	-0.8	-1.0	-1.0	-1.2	-0.6	-1.3
Medication: Lansoprazole	0.7	0.8	1.4	1.1	-1.2	-1.2	-0.3	0.8	-1.1	-0.3	0.6	-1.2	1.1	-0.4	-1.1	-0.7	-0.9	-0.7	-0.8	-1.1	-1.0
Overall health rating	0.7	1.5	3.1	1.1	1.3	1.4	1.8	-1.4	1.1	0.8	1.8	0.6	0.4	1.2	1.2	1.6	1.1	0.9	1.4	1.4	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	7.5	-2.1	-1.2	-1.2	-1.0	1.0	-0.9	-0.7	-2.7	-0.5	-0.5	-1.7	-1.0	-0.5	-0.6	-0.8	-1.1	-1.3	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	3.1	-0.2	0.8	0.8	0.9	-0.6	0.8	0.7	1.5	1.8	0.7	1.0	0.8	0.8	0.7	0.7	0.7	0.9	0.2
Medication: Lisinopril	0.7	0.9	3.8	-0.2	1.2	1.2	0.9	-0.7	1.1	1.0	0.0	-0.2	0.4	0.6	1.1	0.4	0.9	1.1	0.9	0.9	1.9
Basal metabolic rate	0.7	3.7	7.3	-0.5	-2.1	-2.1	-1.9	1.9	-2.1	-1.8	-2.5	0.1	-0.9	-1.4	-2.1	-2.1	-2.2	-2.3	-2.0	-1.8	-2.7
Ever depressed for a whole week	0.7	0.8	3.1	-1.8	0.7	0.8	1.0	-1.3	0.6	0.1	1.1	0.7	-0.7	0.8	0.7	-0.1	0.4	0.4	1.1	0.6	1.4
Schizophrenia (2018)	0.6	1.2	6.1	-1.5	-0.9	-1.0	-0.9	1.1	-0.8	-1.0	0.0	-2.5	-0.8	-0.8	-1.0	-1.5	-1.1	-0.7	-1.1	-1.0	0.5
Alzheimer’s Disease (in mother)	0.6	0.7	3.2	0.3	-0.7	-0.7	-1.0	1.2	-0.6	-0.6	-0.4	-0.5	-0.2	-0.2	-0.9	-1.8	-1.1	-0.6	-1.1	-0.8	0.4
HDL Cholesterol	0.6	1.0	5.9	-0.9	-0.4	-0.4	-0.3	0.5	-0.6	-1.2	-2.4	-0.4	-2.0	-0.2	-0.5	-1.4	-0.7	-0.5	-0.5	-0.9	0.5
Ever had hysterectomy (womb removed)	0.6	0.7	2.5	-1.6	-0.9	-0.9	-0.7	0.2	-1.1	-0.8	0.5	-1.0	-0.2	-0.5	-0.8	-0.8	-1.1	-1.1	-0.3	-0.9	-0.6
Medication: Co-codamol	0.6	0.7	4.8	2.2	-0.3	-0.3	0.6	0.9	-0.5	-0.7	0.5	-0.7	-0.4	-0.1	-0.7	-0.9	-0.8	-0.8	-0.8	-0.5	-0.9
Impedance of leg (right)	0.6	2.7	9.9	-1.4	-1.9	-2.0	-1.1	1.1	-1.5	-0.6	0.1	-3.1	-0.0	-2.3	-1.7	-2.0	-1.4	-0.9	-1.3	-2.8	0.8
Current tobacco smoking	0.6	1.0	3.8	1.9	1.1	1.1	1.1	-0.6	0.8	0.1	1.6	1.1	-0.7	0.4	0.9	1.2	0.7	0.3	0.7	1.1	0.0
Relative age voice broke	0.6	0.9	3.3	1.8	0.9	0.9	1.3	-0.7	1.1	0.5	0.6	0.6	0.1	1.2	0.8	1.2	1.2	1.1	0.7	0.8	-0.2
Alcohol intake versus 10 years previously	0.6	1.0	1.8	-0.3	1.1	1.1	0.9	-1.1	1.1	0.0	0.7	0.8	0.6	1.3	1.1	1.0	1.0	1.2	1.3	0.9	1.2
Father’s age at death	0.6	0.8	2.3	-0.3	-1.0	-1.1	-1.5	0.5	-0.9	-1.1	-1.2	-0.9	-0.4	-0.8	-0.9	-0.6	-0.6	-0.7	-0.7	-1.0	-1.0
Noisy workplace	0.6	0.7	4.8	2.0	-0.1	0.0	0.6	-0.4	-0.3	0.6	2.2	-1.2	1.0	0.1	-0.1	0.1	-0.3	-0.6	0.2	0.0	-0.7
Medication: Cholesterol lowering	0.6	1.0	2.3	-1.3	0.9	0.9	1.1	-0.7	0.8	1.1	1.1	1.1	1.2	0.9	0.8	1.5	0.8	0.4	0.8	1.0	-0.9
Headache pain in last month	0.6	1.0	3.2	0.6	1.1	1.1	0.2	-0.4	1.2	-0.0	-1.0	0.3	-0.4	1.0	1.1	1.8	1.3	1.4	0.7	1.3	0.5
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	2.1	1.0	-1.2	-1.3	-1.5	0.8	-1.0	-1.1	-0.9	-0.6	-0.6	-1.0	-1.0	-1.3	-1.0	-0.7	-0.9	-1.3	0.0
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.0	-0.8	-0.9	-0.9	-0.7	1.4	-0.9	-0.9	-0.7	-1.2	-0.3	-0.8	-0.9	0.0	-0.6	-0.6	-1.2	-0.4	-1.4
Forced vital capacity (FVC), Best measure	0.6	2.3	3.8	-1.0	-1.9	-1.9	-1.9	1.5	-1.6	-1.2	-1.6	0.3	0.0	-1.5	-1.7	-1.4	-1.4	-1.3	-1.7	-1.9	-1.5
Age at first live birth	0.6	1.0	3.0	-1.3	-1.2	-1.3	-1.0	0.7	-0.7	-1.0	-1.7	-1.2	-0.6	-1.6	-0.9	-0.8	-0.5	-0.3	-0.8	-1.0	0.1
Medication for pain relief, constipation, heartburn	0.6	1.1	2.2	1.0	1.1	1.1	0.9	-1.0	1.3	1.2	0.1	1.5	0.6	0.6	1.2	1.3	1.4	1.1	1.0	0.9	0.6
Eye problems/disorders: Cataract	0.6	0.7	2.9	-0.5	-0.8	-0.8	-1.0	0.6	-0.7	-0.0	-1.7	-1.0	-0.1	-0.9	-0.6	-1.3	-0.7	-0.5	-0.7	-0.9	0.4
Breast cancer (self-reported)	0.6	0.7	3.0	-0.3	-0.8	-0.7	-1.3	1.1	-0.9	-0.8	-0.8	0.0	-0.7	-0.5	-0.6	0.3	-0.5	-0.9	-0.9	0.2	-1.7
Average weekly beer plus cider intake	0.6	0.8	3.5	0.9	0.7	0.6	1.1	-0.6	0.9	1.0	1.9	0.3	0.8	0.8	0.7	0.3	0.7	1.0	0.7	0.1	1.3
Heart disease (siblings)	0.6	0.8	6.3	2.5	0.1	0.1	-0.1	0.2	0.2	1.3	0.6	0.3	2.1	-0.3	0.2	0.4	0.4	0.4	-0.1	0.1	0.1
Alcohol drinker status: Previous	0.6	0.7	6.0	-2.4	-0.0	0.0	-0.3	0.1	-0.2	-0.8	-1.0	-0.6	-1.4	0.0	0.0	1.0	0.1	-0.1	-0.0	0.5	-1.0
Reaction Time	0.5	1.0	1.8	-1.3	1.1	1.1	1.2	-1.2	0.9	0.3	0.5	1.1	-0.1	1.1	1.0	1.2	1.1	1.1	1.2	0.7	0.3
Body Mass Index (BMI) (2010)	0.5	0.7	2.3	1.3	-0.5	-0.5	-0.3	0.7	-0.5	0.3	-1.2	-1.5	0.5	-0.7	-0.7	-1.4	-0.9	-0.7	-0.7	-1.1	0.1
Cardiovascular Disease	0.5	1.7	6.7	-1.9	-1.1	-1.1	-0.3	1.0	-1.3	-1.1	0.2	-2.6	-1.8	-0.6	-1.4	-1.5	-1.2	-1.0	-0.9	-1.7	-0.7
Impedance of leg (left)	0.5	2.3	10.0	-1.2	-1.6	-1.7	-0.8	1.0	-1.3	-0.5	0.2	-3.2	0.3	-2.0	-1.5	-1.8	-1.2	-0.6	-1.1	-2.6	0.9
Medication: Simvastatin	0.5	0.7	1.9	-1.4	-0.8	-0.8	-0.5	1.1	-0.9	-0.1	-0.0	-0.1	0.5	-1.0	-0.9	-0.3	-0.9	-1.1	-1.0	-0.8	-1.4
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.7	2.7	0.6	0.7	0.8	0.9	-0.4	0.7	-0.5	1.1	0.2	-0.0	1.6	0.6	1.4	0.7	0.6	0.6	1.4	-1.0
Exposure to tobacco smoke at home	0.5	0.5	1.5	0.8	0.7	0.6	0.8	-0.7	0.8	0.1	0.2	0.3	0.0	1.1	0.7	0.3	0.8	1.1	0.7	0.7	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	2.0	-0.2	-0.9	-0.8	-0.9	0.9	-1.0	-1.4	-1.4	-1.2	-1.1	-1.0	-0.8	-0.7	-0.8	-0.7	-0.9	-0.5	-0.3
High blood pressure (siblings)	0.5	0.8	1.3	1.1	0.7	0.7	0.8	-0.9	0.9	0.9	0.9	0.5	1.0	0.7	0.8	1.0	1.1	1.1	1.0	0.2	1.0
Eye problems/disorders: None of the above	0.5	0.6	3.1	-1.7	-0.5	-0.5	-0.2	0.4	-0.5	-1.8	-0.6	-0.5	-1.2	-0.1	-0.5	-0.0	-0.4	-0.4	-0.4	-0.5	-0.8
Mouth/teeth dental problems: Loose teeth	0.5	0.6	3.8	1.8	0.2	0.2	-0.1	-0.6	0.0	0.8	2.0	0.8	0.9	-0.1	0.2	0.2	-0.1	-0.4	0.6	0.2	-0.2
Alcohol intake frequency.	0.5	1.1	9.8	-3.1	0.1	0.1	-0.5	0.4	-0.1	-1.0	-2.2	-1.2	-1.3	-0.2	-0.1	0.8	0.1	-0.0	-0.1	-0.1	-0.7
Chest pain or discomfort	0.5	0.8	1.6	0.9	0.9	0.9	1.2	-0.8	0.9	1.1	1.3	0.4	0.7	0.7	0.8	1.1	0.9	0.9	0.9	0.5	0.3
Leg fat-free mass (right)	0.5	2.9	5.9	-0.3	-1.8	-1.8	-1.7	1.8	-1.8	-1.7	-2.4	0.7	-0.7	-1.2	-1.8	-1.7	-1.8	-2.0	-1.8	-1.5	-2.3
Medication: Gliclazide	0.5	0.6	2.5	1.2	0.4	0.4	0.6	-0.1	0.1	1.4	1.0	1.6	1.4	0.3	0.3	0.2	0.1	-0.0	0.1	0.9	-0.2
Leg predicted mass (right)	0.5	2.9	6.0	-0.3	-1.8	-1.8	-1.8	1.8	-1.8	-1.8	-2.4	0.7	-0.8	-1.2	-1.8	-1.7	-1.9	-2.0	-1.9	-1.5	-2.3
Medication: Atorvastatin	0.5	0.6	1.6	-0.3	0.8	0.9	0.8	-0.7	0.8	0.2	0.3	0.3	-1.0	1.3	0.8	0.7	0.7	0.6	0.8	1.2	-0.0
Pack years of smoking	0.5	0.7	9.1	3.0	-0.2	-0.1	0.2	0.1	-0.3	0.6	1.3	-0.0	0.3	-0.1	-0.4	-0.9	-0.5	-0.4	-0.2	-0.5	-0.1
Alzheimer’s Disease (in father)	0.4	0.4	2.5	0.1	0.1	0.2	0.3	-0.0	0.1	-0.1	1.2	1.6	-0.7	1.3	-0.2	-0.4	-0.3	-0.2	0.0	0.3	-0.6
Major Depression (MDD)	0.4	0.4	2.5	1.3	0.6	0.6	0.3	-0.1	0.4	0.7	-0.5	-1.6	-0.4	0.3	0.5	0.6	0.4	0.1	0.2	0.9	-0.4
Lupus	0.4	0.5	1.5	1.2	0.4	0.4	0.6	-0.8	0.7	0.7	-0.4	1.1	-0.1	0.9	0.5	1.1	1.0	0.8	0.7	0.5	-0.3
Triglycerides	0.4	0.7	3.9	0.4	0.4	0.5	0.3	0.2	0.7	1.1	2.0	-0.1	1.7	-0.1	0.5	1.2	0.7	0.6	0.1	0.7	0.2
Smoking Status	0.4	1.0	3.3	0.7	1.1	1.2	0.6	-0.7	0.8	-0.5	1.8	1.6	-1.4	0.7	0.9	1.3	0.7	0.2	0.7	1.3	-0.7
Respiratory disease	0.4	0.9	5.8	0.3	-0.7	-0.7	-1.1	0.9	-0.7	-1.4	-0.9	-2.4	-0.9	-0.6	-0.5	0.4	-0.5	-0.7	-0.7	-0.1	-1.2
Hand grip strength (left)	0.4	1.1	5.5	1.1	-0.9	-0.9	-0.9	0.6	-1.2	0.0	-0.4	0.6	-0.3	-0.7	-1.0	-1.1	-1.1	-1.5	-1.0	-0.7	-2.3
Systolic blood pressure, automated reading	0.4	1.2	6.3	-0.1	-1.1	-1.2	-0.8	0.3	-0.8	0.6	1.7	-2.5	1.5	-0.6	-1.0	-1.1	-0.7	-0.4	-0.5	-1.5	-0.1
Angina	0.4	0.5	3.5	0.6	-0.5	-0.4	-0.2	0.8	-0.8	-0.8	0.3	0.2	-0.2	-0.4	-0.7	0.3	-0.6	-0.9	-0.7	-0.1	-1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	2.2	0.9	0.7	0.7	0.2	-0.2	0.6	0.1	0.0	0.5	0.6	0.8	0.7	1.5	0.8	0.7	0.5	1.1	-0.2
Hayfever, allergic rhinitis or eczema	0.4	0.9	4.6	-1.5	0.7	0.7	0.7	-0.1	0.6	0.0	0.2	-0.7	-1.1	0.6	0.8	2.1	1.1	0.7	0.3	1.5	-1.2
Had menopause	0.4	0.5	1.8	1.3	0.3	0.3	-0.4	-0.8	0.3	0.5	1.3	1.4	0.9	0.0	0.5	1.1	0.4	0.0	0.8	0.5	-0.3
Financial difficulties in last 2 years	0.4	0.6	2.1	-1.5	0.5	0.5	0.7	-0.7	0.5	-0.4	-1.3	0.9	-1.2	0.6	0.5	0.8	0.6	0.6	0.6	0.4	0.1
Allergy	0.4	0.9	3.2	1.2	0.0	-0.0	0.1	-0.8	0.1	0.7	0.8	1.6	1.8	0.2	-0.1	-1.5	-0.4	0.1	0.5	-0.8	1.7
Medication: Ramipril	0.4	0.5	3.5	-0.3	-0.9	-0.9	-0.1	0.1	-0.8	-0.2	0.4	-1.9	0.5	-0.6	-0.7	-0.5	-0.6	-0.6	-0.3	-1.0	-0.3
Illnesses of mother	0.4	0.5	1.8	-1.0	-0.9	-1.0	-0.7	0.4	-0.6	0.6	-0.6	-0.5	0.6	-1.4	-0.6	-0.1	-0.2	-0.2	-0.5	-0.9	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	2.4	-1.2	-1.5	-1.5	-1.2	1.1	-1.2	-0.8	-0.8	0.9	0.3	-0.8	-1.3	-0.9	-0.9	-0.8	-1.3	-1.4	-1.3
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.6	0.3	-0.7	-0.8	0.1	0.6	-0.5	-0.7	-0.3	-0.6	-1.1	-0.8	-0.7	-1.2	-0.8	-0.6	-0.6	-0.7	0.5
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	2.3	-0.2	-0.9	-0.9	-0.6	0.4	-0.7	-0.4	-1.5	-0.5	0.2	-1.1	-0.6	-0.3	-0.4	-0.4	-0.6	-0.9	-0.3
Birth weight	0.4	0.8	2.9	0.7	-0.5	-0.5	-0.7	1.0	-0.5	-1.1	-0.3	-1.7	-1.2	-0.7	-0.6	-1.4	-0.7	-0.7	-0.9	-0.8	0.4
Comparative body size at age 10	0.4	1.0	4.8	2.2	0.5	0.5	1.4	-0.2	0.4	0.7	1.8	0.3	0.9	1.4	0.3	-0.8	-0.0	0.5	0.2	1.1	1.0
Number of children fathered	0.4	0.4	1.2	0.6	-0.3	-0.3	-0.1	1.0	-0.5	0.3	-0.9	0.3	0.5	-0.7	-0.5	-0.3	-0.7	-1.0	-0.9	0.1	-1.1
Number of full sisters	0.4	0.5	2.6	-0.8	-0.6	-0.6	-0.1	0.9	-0.8	-0.9	-0.6	0.2	0.0	-0.6	-0.7	0.4	-0.6	-0.9	-0.8	-0.5	-1.6
Had major operations	0.4	0.4	1.1	-0.2	-0.8	-0.8	-0.8	0.3	-0.5	-0.2	-0.9	-1.0	-1.0	-0.3	-0.6	-0.7	-0.4	-0.5	-0.5	-0.5	-0.9
Medication: Aspirin	0.4	0.5	1.9	-0.3	0.4	0.5	0.7	-0.4	0.3	1.1	1.4	0.5	1.3	0.9	0.4	0.7	0.3	0.2	0.5	0.5	-0.7
Hypertension (Self-reported)	0.4	1.0	8.0	-2.8	-0.5	-0.5	0.3	-0.1	-0.5	-0.5	0.4	-2.4	-0.9	0.1	-0.6	-0.9	-0.4	-0.1	-0.1	-0.9	0.3
Average weekly red wine intake	0.4	0.6	5.3	-2.3	-0.8	-0.8	0.2	0.4	-0.6	-0.5	-1.1	-0.4	-0.6	-0.6	-0.7	-0.2	-0.4	-0.4	-0.5	-0.4	-0.9
Back pain experienced in last month	0.4	0.6	1.7	-0.7	0.7	0.6	0.9	-0.7	0.8	0.2	0.7	-0.5	0.3	1.3	0.7	0.8	0.9	1.2	0.7	0.6	0.7
Illnesses of father: None of the above (group 1)	0.4	0.5	2.1	0.4	0.3	0.3	0.9	0.1	0.1	-1.0	-0.2	1.2	-1.5	1.1	-0.1	0.0	-0.1	-0.2	-0.0	0.4	-0.9
Smoking status: Current	0.4	0.7	2.3	1.5	0.9	1.0	0.9	-0.4	0.6	-0.1	1.4	1.2	-0.8	0.3	0.7	1.0	0.4	0.0	0.5	1.0	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	2.0	-0.5	-1.1	-1.1	-0.8	0.8	-0.9	-0.4	-1.2	-0.6	0.5	-0.3	-1.1	-0.9	-1.0	-0.8	-0.8	-1.4	-1.0
Miserableness	0.4	0.8	2.9	-0.3	0.9	0.9	0.7	-0.2	1.0	0.4	0.3	-0.4	0.5	1.0	1.0	1.7	1.1	1.0	0.5	1.7	0.2
Financial situation satisfaction	0.4	0.5	1.9	-1.4	0.5	0.5	1.0	-0.7	0.6	0.1	0.8	0.2	-1.3	0.3	0.5	0.9	0.9	0.8	0.6	0.3	-0.3
Age started oral contraceptive pill	0.4	0.5	3.2	1.8	0.7	0.7	0.4	-0.4	0.8	0.6	0.4	-0.1	-0.2	0.2	0.8	0.2	0.6	0.4	0.4	0.9	1.0
Commuting to job workplace: Cycle	0.4	0.5	1.3	1.1	0.7	0.7	0.9	-0.7	0.8	0.2	0.1	0.6	0.2	0.4	0.8	0.6	0.7	0.6	0.7	1.0	0.8
Pain experienced in last month	0.4	0.6	1.8	-0.9	-0.6	-0.6	-0.5	0.6	-0.8	-0.1	0.6	0.1	-0.6	-1.3	-0.8	-0.6	-0.7	-1.1	-0.7	-0.8	-1.3
Neuroticism (Nagel 2018)	0.3	0.6	1.9	-0.1	0.8	0.8	0.3	-0.8	0.7	-0.4	-0.2	-0.6	-0.9	0.9	0.9	0.9	0.9	0.9	0.9	1.4	0.5
Verbal and Numeric Reasoning (VNR)	0.3	0.8	4.1	-2.0	0.3	0.2	0.1	-0.9	0.8	-0.3	1.7	0.5	0.5	0.4	0.7	0.7	1.0	1.2	0.8	0.3	1.3
Rheumatoid Arthritis	0.3	0.4	2.4	1.6	-0.0	0.0	0.0	0.1	-0.3	0.1	0.9	-0.2	-0.7	-0.3	-0.3	-0.7	-0.6	-0.8	-0.2	-0.2	-1.0
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.6	-0.8	-0.8	-0.2	0.0	0.1	-0.2	-0.7	1.3	-0.7	-0.8	-0.4	-0.0	0.5	0.1	0.1	-0.1	0.0	-0.7
Systolic Blood Pressure	0.3	1.5	11.0	-1.0	-0.7	-0.8	-0.1	0.2	-0.4	0.9	3.3	-2.9	1.3	-0.4	-0.5	-0.4	0.1	0.5	-0.3	-1.0	0.5
Neuroticism	0.3	0.6	2.5	-0.1	0.8	0.7	0.4	-0.7	0.9	-0.3	0.1	-0.6	-0.6	0.9	0.9	0.9	1.0	1.0	0.7	1.6	0.9
Relative age of first facial hair	0.3	0.6	2.4	-0.9	-0.6	-0.6	-0.2	0.5	-0.5	-0.6	-0.4	-1.2	-1.5	-0.7	-0.6	-0.2	-0.1	-0.2	-0.7	-0.7	-1.4
Pack years adult smoking proportion	0.3	0.5	6.9	2.6	-0.1	-0.0	0.4	0.1	-0.2	0.4	1.1	0.1	-0.2	0.0	-0.3	-0.7	-0.4	-0.4	-0.2	-0.4	-0.2
Hand grip strength (right)	0.3	0.8	5.5	2.3	-0.5	-0.5	-0.0	-0.0	-0.7	0.7	-0.4	0.6	0.0	-0.1	-0.7	-1.0	-0.7	-0.9	-0.4	-0.7	-1.7
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.5	-1.0	-0.1	-0.0	0.6	0.6	-0.2	-0.2	0.2	-0.5	-0.9	0.1	-0.4	0.2	-0.2	-0.3	-0.5	-0.3	-1.2
High blood pressure	0.3	0.7	5.9	-2.4	-0.2	-0.2	0.6	-0.5	-0.1	-0.2	1.0	-2.0	-0.2	0.3	-0.2	-0.6	-0.0	0.3	0.3	-0.7	0.8
Stomach or abdominal pain in last month	0.3	0.4	2.5	-0.7	-0.1	-0.1	0.1	-0.1	-0.3	-1.1	-0.2	-1.6	-1.4	0.1	-0.2	0.2	-0.0	-0.1	0.0	-0.1	-1.1
Fluid intelligence score	0.3	0.7	4.8	-2.2	0.1	0.0	-0.0	-0.6	0.6	-0.3	0.5	0.5	0.1	0.4	0.5	0.1	0.6	1.1	0.6	-0.0	2.0
Worrier / anxious feelings	0.3	0.6	5.4	-0.1	0.3	0.3	0.1	-0.0	0.1	-1.3	0.3	-1.3	-2.3	0.8	0.2	0.1	0.2	0.2	-0.0	1.1	-0.2
Hair/balding pattern: Pattern 3	0.3	0.5	2.8	-0.8	-0.0	-0.1	0.7	0.3	0.3	-0.0	1.7	0.5	1.1	0.3	0.0	1.1	0.6	0.5	-0.3	0.5	-1.0
Worry too long after embarrassment	0.3	0.5	2.4	-1.6	0.3	0.3	0.4	-0.5	0.4	-0.7	-0.2	-1.2	-0.9	0.2	0.5	0.5	0.4	0.4	0.5	1.2	1.0
Wheeze or whistling in the chest in last year	0.3	0.5	4.8	2.2	-0.4	-0.4	0.1	0.1	-0.4	0.4	0.2	-1.1	0.5	-0.1	-0.4	-0.6	-0.4	-0.3	-0.2	-0.8	-0.3
Qualifications: College or University degree	0.3	1.1	4.7	-2.2	-0.9	-1.0	-0.6	0.5	-0.6	-1.5	-1.2	-1.4	-1.8	-1.0	-0.6	-0.6	-0.4	-0.3	-0.5	-0.7	0.5
Age at last live birth	0.3	0.5	1.1	-0.9	-0.9	-1.0	-0.7	0.5	-0.5	-0.7	-1.0	-1.0	-0.7	-0.8	-0.6	-0.6	-0.3	-0.0	-0.6	-0.5	0.0
Commuting to job workplace: Car/motor vehicle	0.3	0.3	2.3	-0.8	0.4	0.4	0.0	-0.5	0.2	0.9	0.1	-0.1	1.5	0.7	0.3	-0.1	0.0	0.2	0.6	0.1	0.3
Illnesses of siblings: Diabetes	0.3	0.4	3.3	0.8	-0.2	-0.1	0.2	-0.4	-0.2	0.3	1.1	0.8	1.8	0.7	-0.0	0.1	-0.1	0.2	0.4	-0.1	0.2
Smoking status: Previous	0.3	0.4	2.1	-1.5	-0.3	-0.3	-0.6	0.2	-0.4	-1.3	-0.4	-0.6	-0.9	-0.5	-0.4	-0.3	-0.3	-0.3	-0.4	-0.1	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.8	-0.2	-0.7	-0.7	-0.9	0.5	-0.8	-0.4	-0.4	-0.7	0.2	-0.7	-0.6	-0.5	-0.6	-0.7	-0.6	-0.6	-0.9
Eye problems/disorders: Glaucoma	0.3	0.4	2.3	1.1	0.0	0.0	0.3	-0.3	0.2	1.5	-0.2	0.1	1.0	-0.5	0.3	1.1	0.5	0.1	0.3	0.2	-0.6
Medication: Blood pressure	0.3	0.6	3.9	-1.1	-0.6	-0.6	0.2	0.2	-0.6	-0.6	1.2	-2.0	-0.2	-0.0	-0.7	-0.7	-0.5	-0.1	-0.3	-0.9	-0.0
High cholesterol (Self-reported)	0.3	0.5	2.4	-1.5	-0.3	-0.2	-0.1	0.5	-0.5	-0.3	-0.2	-0.6	-1.4	-0.7	-0.4	0.4	-0.3	-0.7	-0.4	-0.3	-1.4
Illnesses of father: High blood pressure	0.3	0.3	2.2	-1.5	-0.4	-0.4	-0.2	0.4	-0.3	-0.4	0.3	-0.9	-0.3	-0.3	-0.3	-0.7	-0.3	-0.2	-0.4	-0.6	0.6
Alcohol drinker status: Never	0.3	0.4	2.0	0.3	0.6	0.6	0.2	-0.4	0.7	0.7	-0.0	0.2	0.6	0.3	0.6	0.4	0.7	0.8	0.5	0.3	1.4
Arm fat-free mass (left)	0.3	1.5	5.8	0.0	-1.3	-1.2	-1.2	1.1	-1.3	-0.9	-1.9	0.6	-0.6	-0.5	-1.2	-1.1	-1.4	-1.6	-1.2	-0.8	-2.4
Unable to work because of sickness or disability	0.3	0.4	1.0	0.6	-0.4	-0.3	-0.0	0.9	-0.6	-0.1	0.4	-0.6	-0.1	-0.6	-0.6	-0.4	-0.8	-1.0	-0.8	-0.2	-0.8
Vascular/heart problems diagnosed by doctor	0.3	0.8	7.6	2.8	0.3	0.3	-0.5	-0.0	0.3	0.5	-0.9	1.9	0.3	-0.3	0.4	0.6	0.2	-0.2	0.0	0.8	-0.2
Supplements: Calcium	0.3	0.3	0.7	-0.3	0.7	0.7	0.7	-0.5	0.8	0.1	0.8	0.6	-0.0	0.4	0.6	0.5	0.5	0.5	0.5	0.8	0.5
Intelligence (Savage-Jansen 2018)	0.2	0.6	5.6	-2.4	-0.3	-0.4	-0.8	-0.1	0.1	-1.0	1.2	-0.0	0.4	-0.5	-0.0	0.1	0.2	0.5	0.0	-0.3	1.2
Fasting Glucose	0.2	0.3	1.4	1.2	0.1	0.1	-0.7	0.5	0.0	0.6	1.1	-0.4	-0.3	0.4	-0.0	-0.1	-0.3	-0.4	-0.4	0.7	-0.6
Neuroticism (2016)	0.2	0.4	1.9	0.2	-0.1	-0.0	0.0	0.6	-0.2	-1.3	-0.3	-0.4	-1.4	0.2	-0.3	0.3	-0.1	-0.3	-0.5	0.5	-1.2
Blood Eosinophil Count	0.2	1.3	5.4	-1.1	0.4	0.4	1.5	-0.3	0.4	1.9	2.0	1.4	0.3	0.3	0.3	1.3	1.1	0.6	0.0	0.7	-2.3
Hearing difficulty/problems: Yes	0.2	0.3	0.9	-0.6	-0.5	-0.4	-0.0	0.4	-0.5	-0.6	-0.1	-1.0	-0.2	-0.4	-0.6	-0.7	-0.7	-0.7	-0.4	-0.7	-0.2
Qualifications: CSEs or equivalent	0.2	0.3	0.8	0.2	-0.5	-0.4	-0.0	0.3	-0.7	0.0	-0.3	-0.9	0.8	0.1	-0.6	-0.3	-0.6	-0.5	-0.3	-0.9	-0.9
Medication: Atenolol	0.2	0.2	1.0	-0.2	-0.5	-0.5	0.0	0.1	-0.4	-0.5	1.0	-0.1	0.1	-0.0	-0.5	-0.8	-0.5	-0.3	-0.2	-0.5	0.5
High blood pressure (mother)	0.2	0.3	1.1	-0.1	0.4	0.4	0.6	-0.6	0.2	-0.2	0.7	-0.7	-0.3	1.1	0.4	0.4	0.2	0.2	0.6	0.8	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.1	0.5	0.3	0.3	0.4	0.2	0.6	-0.0	-0.5	-1.1	0.0	0.4	0.4	0.7	0.5	0.6	0.0	1.0	0.7
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.8	-0.5	0.5	0.6	-0.1	-0.8	0.4	0.4	0.9	-0.7	-0.1	0.5	0.6	0.2	0.4	0.4	0.6	0.5	0.6
Neuroticism score	0.2	0.5	2.2	-0.8	0.2	0.2	0.0	0.1	0.3	-1.0	-0.1	-1.5	-1.2	0.3	0.4	0.8	0.5	0.4	-0.0	1.4	-0.2
Falls in the last year	0.2	0.3	1.0	-0.1	-0.6	-0.7	-0.4	0.8	-0.4	-0.1	-0.3	0.4	1.0	-0.4	-0.5	-0.1	-0.5	-0.5	-0.6	-0.6	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.7	0.4	0.3	0.3	0.5	-0.3	0.1	0.6	0.5	0.8	0.8	0.4	0.3	0.8	0.4	0.3	0.2	0.7	-0.8
Standing height	0.2	2.0	3.7	0.3	-1.7	-1.8	-1.4	1.4	-1.4	-0.5	-1.1	1.1	1.1	-1.9	-1.6	-1.3	-1.2	-1.4	-1.6	-1.7	-1.8
Tense / ‘highly strung’	0.2	0.4	2.2	0.2	-0.2	-0.2	-0.3	0.7	-0.2	-1.5	0.1	-0.8	-0.8	0.1	-0.3	-0.8	-0.5	-0.2	-0.5	0.5	0.8
Blood clot in the leg (DVT)	0.2	0.2	0.8	-0.4	0.5	0.5	0.2	-0.0	0.5	0.4	-0.5	0.9	-0.7	0.3	0.5	0.3	0.5	0.4	0.2	0.4	0.5
Arm fat-free mass (right)	0.2	1.3	4.4	0.5	-1.0	-1.0	-0.9	1.1	-1.0	-0.7	-2.0	0.9	-0.7	-0.2	-1.0	-1.0	-1.1	-1.4	-1.2	-0.5	-2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	1.0	0.0	-0.4	-0.4	-0.7	1.0	-0.5	-1.0	-0.1	-0.9	-0.0	-0.1	-0.4	-0.0	-0.3	-0.3	-0.8	-0.0	-0.8
Angina (self-reported)	0.2	0.3	2.7	0.7	-0.2	-0.2	0.0	0.6	-0.5	-0.5	0.4	0.3	0.1	-0.2	-0.4	0.6	-0.3	-0.6	-0.4	0.1	-1.6
Arm predicted mass (right)	0.2	1.1	4.2	0.7	-0.9	-0.9	-0.9	1.0	-0.9	-0.6	-2.0	0.9	-0.5	-0.2	-0.9	-0.9	-1.1	-1.3	-1.1	-0.5	-2.0
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	1.5	-1.0	0.3	0.3	-0.9	0.1	0.2	0.4	-0.1	-0.1	1.2	-0.2	0.2	0.1	0.1	0.3	0.1	0.0	1.0
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	3.8	1.9	0.0	-0.0	-0.3	-0.1	0.3	0.3	0.7	-0.3	0.5	-0.4	0.1	-0.0	0.1	0.1	0.1	-0.3	0.6
Whole body fat-free mass	0.2	1.2	5.2	0.2	-1.0	-1.0	-0.9	1.0	-1.0	-0.8	-1.9	1.3	-0.4	-0.3	-1.0	-0.8	-1.0	-1.3	-1.1	-0.5	-2.3
Medication: Aspirin	0.2	0.3	1.9	-0.3	-0.0	0.0	0.2	-0.3	-0.0	1.1	0.8	0.3	1.4	0.5	0.0	0.3	0.0	-0.0	0.3	0.0	-0.7
Whole body water mass	0.2	1.2	5.2	0.3	-1.0	-1.0	-1.0	1.0	-1.0	-0.8	-1.9	1.3	-0.5	-0.4	-1.0	-0.8	-1.0	-1.3	-1.1	-0.5	-2.3
Wears glasses or contact lenses	0.2	0.3	1.2	-0.2	-0.4	-0.4	-1.1	0.4	-0.4	-1.1	-0.3	0.1	-0.3	-0.5	-0.3	-0.0	-0.3	-0.5	-0.4	-0.1	-0.5
Pain type(s) experienced in last month: Hip pain	0.2	0.2	1.3	0.4	-0.2	-0.1	-0.0	0.1	-0.2	0.3	1.1	0.4	1.1	-0.4	-0.1	-0.0	-0.4	-0.3	0.2	-0.3	0.6
Irritability	0.2	0.3	3.4	0.7	-0.2	-0.2	0.2	0.4	-0.1	-0.3	0.1	-1.8	-0.8	0.2	-0.2	-0.7	-0.1	0.1	-0.5	0.4	0.4
Arm predicted mass (left)	0.2	1.2	5.2	0.3	-1.1	-1.1	-1.0	1.1	-1.1	-0.7	-1.6	0.7	-0.6	-0.3	-1.1	-1.0	-1.2	-1.4	-1.2	-0.7	-2.3
Worry (Nagel 2018)	0.1	0.2	1.4	-0.1	-0.2	-0.2	-0.5	0.2	-0.2	-0.7	-0.4	-1.2	-1.1	0.0	-0.1	0.1	0.0	-0.0	-0.3	0.7	-0.5
Breast Cancer	0.1	0.3	1.0	0.8	0.6	0.6	0.9	-0.2	0.5	0.3	0.0	-0.6	-1.0	0.8	0.3	0.4	0.6	0.6	0.2	0.2	0.0
HbA1C	0.1	0.1	0.7	-0.0	0.1	0.1	-0.6	-0.0	-0.2	0.1	-0.6	0.1	0.4	0.5	0.0	-0.8	-0.2	-0.0	-0.0	-0.2	0.6
Height	0.1	2.9	10.5	2.0	-1.8	-1.9	-0.9	1.3	-1.4	0.3	-0.6	2.5	3.2	-2.4	-1.3	-1.0	-1.0	-1.3	-1.6	-1.7	-1.6
Lung FEV1/FVC ratio	0.1	0.6	2.9	-1.0	-0.5	-0.5	0.5	0.7	-0.5	-1.0	0.7	0.5	-1.4	0.1	-0.6	0.0	-0.1	-0.3	-0.8	-0.3	-1.7
Lung FVC	0.1	0.7	2.1	0.1	-1.0	-1.1	-1.2	0.9	-0.8	-0.5	-0.3	-0.6	0.7	-0.4	-1.0	-1.3	-0.8	-0.4	-1.0	-1.4	-0.4
Chronotype (morning person)	0.1	0.3	2.3	-0.6	-0.3	-0.3	-0.2	-0.8	-0.2	0.3	0.2	0.6	1.5	0.2	-0.0	-0.1	0.0	0.4	0.6	-0.5	0.8
Number of treatments/medications taken	0.1	0.2	0.9	0.7	-0.4	-0.4	-0.1	0.2	-0.6	-0.1	-0.5	-0.9	0.6	0.5	-0.4	-0.6	-0.6	-0.4	-0.1	0.0	-0.2
Taking other prescription medications	0.1	0.2	1.3	0.8	0.3	0.3	0.1	-0.1	-0.0	0.3	-0.0	0.4	1.1	0.6	0.1	0.3	-0.2	-0.2	0.3	0.5	-0.3
Hair/balding pattern: Pattern 2	0.1	0.2	1.3	0.8	-0.0	-0.0	-0.6	0.1	-0.2	0.1	-1.2	-0.3	-0.8	-0.4	0.0	-0.1	-0.1	-0.1	-0.1	-0.0	-0.3
Had other major operations	0.1	0.1	0.4	-0.7	-0.1	-0.1	0.0	0.4	-0.2	0.2	-0.5	0.1	0.4	-0.0	-0.1	-0.3	-0.1	0.2	-0.3	-0.1	0.2
Forced vital capacity (FVC)	0.1	0.3	0.7	0.2	-0.6	-0.7	-0.4	0.6	-0.4	-0.3	0.0	0.8	0.8	-0.2	-0.6	-0.5	-0.4	-0.2	-0.7	-0.7	-0.5
Heart attack	0.1	0.1	0.8	0.3	-0.2	-0.2	0.0	0.2	-0.2	0.4	-0.0	-0.2	0.8	-0.1	-0.3	0.1	-0.3	-0.5	-0.2	0.0	-0.9
Trunk fat-free mass	0.1	0.6	4.5	0.5	-0.2	-0.2	-0.3	0.2	-0.3	-0.1	-1.3	1.8	-0.1	0.3	-0.2	0.0	-0.2	-0.7	-0.4	0.3	-2.1
Time employed in main current job	0.1	0.1	0.5	0.7	0.2	0.3	-0.3	0.2	0.0	0.0	0.1	0.5	0.3	0.2	0.1	0.3	-0.0	-0.3	-0.1	0.3	-0.7
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	2.2	0.0	-0.3	-0.3	0.2	0.3	-0.0	0.1	0.6	1.5	1.0	0.3	-0.2	-0.2	0.0	0.2	-0.3	-0.1	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.6	0.6	0.2	0.2	0.4	0.0	0.3	0.1	0.2	0.1	0.2	0.8	0.2	0.4	0.4	0.6	0.1	0.5	0.1
Trunk predicted mass	0.1	0.6	4.4	0.4	-0.2	-0.2	-0.2	0.2	-0.2	0.0	-1.3	1.8	-0.1	0.3	-0.2	0.1	-0.2	-0.6	-0.3	0.3	-2.1
Breastfed as a baby	0.1	0.2	0.8	-0.1	-0.2	-0.3	-0.6	0.2	-0.1	-0.3	-0.3	0.1	-0.7	-0.7	-0.1	0.4	0.1	-0.2	-0.3	-0.1	-0.9
Medication: Amlodipine	0.1	0.2	0.8	-0.7	0.2	0.3	0.8	0.0	0.1	0.1	0.9	-0.5	0.3	0.2	0.2	0.6	0.2	0.2	0.1	0.7	0.2
Exposure to tobacco smoke outside home	0.1	0.2	2.0	1.4	-0.0	0.0	0.1	-0.4	-0.2	-0.2	0.3	0.9	-0.2	0.0	-0.1	-0.4	-0.2	-0.0	0.3	-0.0	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	1.4	-1.2	0.0	0.0	-0.2	0.4	-0.0	-0.5	0.1	0.2	-0.1	-0.3	-0.1	-0.0	-0.3	-0.5	-0.2	0.2	-0.3
Neck or shoulder pain in last month	0.1	0.1	0.6	-0.7	0.1	0.1	0.4	-0.4	0.2	-0.2	0.5	0.5	0.3	0.8	0.1	0.0	0.1	0.3	0.4	0.2	0.3
Medication: Blood pressure	0.1	0.2	2.1	-1.4	0.0	0.1	0.2	-0.1	-0.0	0.1	-0.5	-0.8	-0.2	-0.0	0.1	0.0	0.1	0.2	0.1	0.1	0.4
Migraine (self-reported)	0.1	0.1	0.6	0.3	0.2	0.2	-0.7	0.4	0.3	0.1	-0.2	0.6	0.3	-0.1	0.3	0.8	0.4	0.4	-0.2	0.3	-0.0
Suffer from ‘nerves’	0.1	0.2	0.8	-0.3	-0.6	-0.6	-0.1	0.5	-0.4	-0.1	-0.2	-0.5	-0.0	-0.9	-0.4	-0.2	-0.2	-0.3	-0.6	-0.1	-0.5
Mood swings	0.1	0.2	1.0	-1.0	0.1	0.1	0.1	0.1	0.1	-0.6	-0.2	-0.6	-0.6	0.4	0.1	0.6	0.4	0.3	-0.1	0.6	-0.4
Long-standing illness, disability or infirmity	0.1	0.1	0.3	0.5	0.2	0.2	0.5	0.2	-0.1	-0.5	-0.4	-0.1	-0.6	0.4	-0.0	0.1	-0.2	-0.2	0.0	0.2	-0.1
Number of self-reported non-cancer illnesses	0.1	0.1	0.4	-0.5	0.2	0.2	-0.2	-0.3	-0.1	0.1	-0.6	-0.6	0.2	0.4	0.1	0.5	0.1	0.0	0.3	0.2	-0.5
Risk taking	0.1	0.2	1.5	-0.1	0.1	0.2	0.4	-0.2	-0.1	-0.3	0.1	1.2	-0.6	0.6	0.1	-0.8	-0.4	-0.3	0.1	0.2	0.4
Heart attack/myocardial infarction (self-reported)	0.1	0.1	1.0	0.2	-0.2	-0.2	0.0	0.3	-0.2	0.3	-0.1	-0.2	0.7	-0.1	-0.3	0.2	-0.3	-0.5	-0.2	0.0	-1.0
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.9	-0.6	0.1	0.1	-0.2	0.4	0.0	-0.0	-0.8	0.8	-0.9	-0.0	0.0	-0.0	-0.0	-0.1	-0.2	0.1	-0.1
Ulcerative Colitis (UC)	0.0	0.1	0.4	0.2	-0.2	-0.2	-0.4	-0.3	-0.0	0.1	0.1	0.1	0.7	0.1	-0.1	0.3	0.2	0.3	0.1	-0.0	-0.2
Hair Pigment	0.0	0.2	2.0	0.9	0.2	0.2	0.3	0.0	-0.3	-0.2	-0.3	-0.1	-1.4	0.5	0.0	-0.3	0.1	0.3	-0.0	0.2	-0.2
Tanning	0.0	0.5	1.5	-1.0	-0.6	-0.6	-0.4	0.9	-0.6	-0.1	-1.1	0.2	-0.0	-0.6	-0.6	-1.2	-0.7	-0.5	-0.9	-0.8	0.1

Hub : Genes

ASB16

Models

Trait associations