Best TWAS P=1.99e-09 · Best GWAS P=3.75e-09 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | DPY19L3 | 0.07 | 0.05 | lasso | 2 | 0.06 | 8.7e-08 | -5.9 | -6.0 | 2.0e-09 | 0.96 | 0.01 | 0.99 | TRUE |
2 | GTEx | Cells Transformed fibroblasts | DPY19L3 | 0.19 | 0.12 | lasso | 6 | 0.10 | 9.4e-08 | -5.5 | -5.3 | 8.8e-08 | 0.81 | 0.02 | 0.98 | FALSE |
3 | GTEx | Esophagus Mucosa | ZNF507 | 0.10 | 0.02 | lasso | 3 | 0.01 | 9.1e-02 | -4.6 | -5.2 | 2.2e-07 | 0.53 | 0.06 | 0.82 | FALSE |
4 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DPY19L3 | 0.04 | 0.03 | blup | 60 | 0.02 | 2.2e-03 | -5.5 | -5.2 | 2.0e-07 | 0.77 | 0.02 | 0.90 | FALSE |
5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ZNF507 | 0.04 | 0.02 | blup | 38 | 0.03 | 1.0e-04 | -5.4 | -5.5 | 3.7e-08 | 0.63 | 0.01 | 0.98 | FALSE |
6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DPY19L3 | 0.05 | 0.06 | blup | 62 | 0.05 | 1.3e-06 | -5.5 | -5.3 | 1.1e-07 | 0.81 | 0.02 | 0.98 | FALSE |
7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ZNF507 | 0.05 | 0.03 | blup | 39 | 0.05 | 1.3e-06 | -5.0 | -5.6 | 1.7e-08 | 0.67 | 0.02 | 0.98 | FALSE |
8 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | DPY19L3 | 0.04 | 0.04 | lasso | 1 | 0.03 | 7.5e-05 | -5.5 | -5.5 | 4.5e-08 | 0.81 | 0.02 | 0.98 | FALSE |
9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | DPY19L3 | 0.04 | 0.05 | blup | 60 | 0.03 | 6.1e-04 | -5.5 | -5.4 | 6.1e-08 | 0.80 | 0.02 | 0.97 | FALSE |
10 | The Cancer Genome Atlas | Thyroid Carcinoma | DPY19L3 | 0.05 | 0.04 | enet | 9 | 0.05 | 2.1e-05 | -5.5 | -5.8 | 7.2e-09 | 0.87 | 0.02 | 0.98 | FALSE |
11 | The Cancer Genome Atlas | Thyroid Carcinoma | ZNF507 | 0.14 | 0.14 | lasso | 5 | 0.18 | 2.4e-17 | -5.4 | -5.7 | 9.7e-09 | 0.73 | 0.01 | 0.99 | FALSE |