Hub : Genes

DPY19L3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0690	0.0230	2.7e-04	0.055	0.037	0.057	0.054	0.060	2.8e-07	2.0e-05	1.9e-07	3.1e-07	8.7e-08
2	GTEx	Cells Transformed fibroblasts	0.1940	0.0630	2.4e-04	0.115	NA	0.072	NA	0.097	6.0e-09	NA	4.5e-06	NA	9.4e-08
3	GTEx	Nerve Tibial	0.1437	0.0530	3.8e-03	0.041	NA	0.025	NA	0.034	6.6e-04	NA	6.2e-03	NA	1.9e-03
4	NTR	Blood	0.0304	0.0112	4.9e-04	0.008	0.009	0.016	0.012	0.013	9.2e-04	3.9e-04	6.0e-06	5.9e-05	3.7e-05
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0376	0.0204	2.9e-03	0.025	0.020	0.010	NA	0.015	6.6e-04	2.2e-03	2.1e-02	NA	6.3e-03
6	TCGA	Brain Lower Grade Glioma	0.0538	0.0245	6.9e-06	0.058	0.052	0.049	NA	0.050	3.7e-07	1.3e-06	2.7e-06	NA	2.0e-06
7	TCGA	Lung Adenocarcinoma	0.0215	0.0127	4.9e-03	0.018	0.017	0.008	NA	0.016	2.7e-03	3.8e-03	3.2e-02	NA	4.9e-03
8	TCGA	Lung Squamous Cell Carcinoma	0.0374	0.0184	8.9e-04	0.037	0.021	0.025	NA	0.035	4.0e-05	1.8e-03	6.8e-04	NA	7.5e-05
9	TCGA	Prostate Adenocarcinoma	0.0419	0.0208	1.2e-04	0.046	0.028	0.014	NA	0.023	1.2e-05	6.1e-04	1.1e-02	NA	1.7e-03
10	TCGA	Thyroid Carcinoma	0.0480	0.0220	2.3e-04	0.037	0.043	0.047	NA	0.043	1.5e-04	4.7e-05	2.1e-05	NA	4.3e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.4	0.7	3.1	0.4	0.4	1.8	-1.4	0.4	1.1	-0.2	0.1	-0.1	0.6
Bipolar Disorder or Schizophrenia	0.3	0.7	3.8	0.5	0.3	1.9	-1.1	0.6	0.9	-0.7	0.1	0.1	0.6
Depressed Affect (Nagel 2018)	15.0	31.5	44.9	-6.7	-6.7	-2.8	0.7	-5.6	-6.1	-5.3	-6.4	-6.2	-6.3
Depression (Nagel 2018)	7.8	11.8	17.6	-4.0	-4.2	-1.6	1.5	-3.5	-4.0	-3.1	-3.6	-3.5	-3.9
Intelligence (Savage-Jansen 2018)	2.1	6.5	10.6	3.2	3.0	0.6	-0.4	2.0	2.5	2.8	3.1	2.9	2.9
Neuroticism (Nagel 2018)	9.0	21.1	31.0	-5.5	-5.6	-2.0	0.4	-4.1	-4.7	-4.8	-5.5	-5.2	-5.1
Schizophrenia (2018)	0.1	0.2	1.1	0.3	0.0	1.1	-0.3	0.4	0.3	-0.7	0.1	0.1	0.2
Schizophrenia vs Biploar Disorder	1.1	1.4	3.3	-1.3	-1.3	-1.8	-0.1	-1.5	-1.5	-0.3	-1.0	-0.4	-1.3
Worry (Nagel 2018)	1.4	2.9	5.4	-1.8	-2.1	-0.1	-1.6	-1.3	-0.9	-2.2	-2.1	-2.3	-1.4
Alzheimer’s Disease (in mother)	0.4	0.4	1.0	-0.5	-0.8	-1.0	0.8	-0.7	-0.5	0.2	-0.3	-0.7	-0.6
Alzheimer’s Disease (in father)	0.7	0.8	3.3	0.4	0.6	1.8	-0.7	1.3	0.9	-0.2	0.6	-0.2	0.6
Alzheimer’s Disease (including proxy)	0.1	0.1	0.4	0.2	-0.2	-0.3	0.3	0.2	0.2	0.7	0.3	-0.2	-0.0
Crohns Disease (2017)	0.4	0.9	2.8	-0.9	-0.6	-0.9	-0.5	-1.7	-1.1	0.1	-1.1	-0.2	-1.1
Irritable Bowel Disease (IBD)	0.3	0.8	3.1	-0.5	-0.6	-1.2	-0.7	-1.8	-1.0	0.5	-0.8	-0.1	-0.8
Ulcerative Colitis (UC)	0.1	0.2	0.8	0.3	0.0	-0.6	-0.4	-0.9	-0.3	0.8	0.1	0.2	0.1
Major Depression (MDD)	0.1	0.2	0.7	0.4	0.2	0.8	0.1	-0.2	0.4	0.5	0.2	0.2	0.4
Reaction Time	0.5	1.0	2.9	0.8	0.8	-1.4	1.0	0.3	0.5	1.7	0.9	1.1	0.7
Verbal and Numeric Reasoning (VNR)	1.0	2.5	4.3	2.1	1.9	0.1	-0.1	1.6	1.5	1.5	1.9	1.6	1.9
Breast Cancer	0.1	0.2	0.6	0.3	0.2	0.0	0.2	0.7	0.5	0.1	0.8	-0.3	0.5
Ovarian Cancer	1.6	2.2	5.5	-1.8	-1.2	1.3	-1.4	-0.7	-0.6	-2.3	-0.9	-2.3	-1.0
Prostate Cancer	0.4	0.5	2.4	0.6	-0.1	1.1	-1.6	0.4	0.5	0.2	0.4	-0.1	0.5
Age at First Birth	3.2	4.6	7.7	2.4	2.2	0.9	-1.5	2.7	2.8	1.8	2.1	1.5	2.7
Bipolar Disorder (2011)	2.7	2.6	5.1	1.7	1.6	0.9	-1.6	1.6	2.3	1.0	1.8	1.0	2.1
Body Mass Index (BMI) (2010)	2.9	4.0	8.4	-2.3	-2.1	0.5	1.0	-1.6	-1.7	-2.0	-2.6	-2.9	-2.1
Coronary Artery Disease (CAD)	0.5	0.6	4.5	-0.3	0.5	0.6	-2.1	0.4	0.1	-0.6	0.2	-0.2	0.2
Crohns Disease (2012)	0.5	0.7	1.3	-1.0	-0.5	0.0	-1.0	-1.1	-0.7	-0.8	-1.1	-0.8	-0.9
Mean Putamen Volume	1.2	1.4	2.8	1.4	1.2	0.1	-0.5	1.4	1.1	0.7	1.2	1.7	1.4
Fasting Glucose	0.1	0.1	0.3	-0.3	-0.2	0.0	0.3	-0.3	-0.4	-0.0	-0.1	-0.6	-0.2
HbA1C	0.7	0.7	2.0	-1.0	-0.8	0.0	-0.3	-0.4	-0.8	-1.4	-1.1	-1.1	-0.8
HDL Cholesterol	8.3	13.8	19.7	4.3	4.2	1.2	0.2	4.3	3.8	3.6	4.4	4.0	4.3
LDL Cholesterol	0.8	1.2	2.2	-1.0	-1.0	-1.4	1.3	-1.2	-1.5	-0.2	-1.2	-0.1	-1.3
Lupus	0.3	0.5	2.8	-0.7	-0.2	0.6	-1.7	-0.4	-0.1	-0.5	-0.5	-0.6	-0.4
Neuroticism (2016)	5.8	8.4	12.8	-3.3	-3.3	-0.8	0.8	-3.2	-3.0	-2.6	-3.6	-3.2	-3.3
Primary Biliary Cirrhosis	1.0	1.4	2.6	-1.2	-1.2	-1.5	-1.6	-1.5	-1.2	-0.2	-1.0	-0.2	-1.3
Rheumatoid Arthritis	0.1	0.1	0.8	0.3	0.1	0.9	0.0	0.0	0.3	0.3	0.1	-0.5	0.2
Schizophrenia (2014)	0.3	0.7	2.2	-0.5	-0.9	1.1	-0.9	-0.5	-0.2	-1.5	-0.9	-0.7	-0.4
Triglycerides	5.2	8.6	13.0	-3.3	-3.4	-0.6	1.7	-3.6	-3.1	-2.2	-3.3	-3.3	-3.3
Type 2 Diabetes (T2D) (2012)	0.4	0.4	2.0	0.2	0.5	0.1	0.8	0.0	-0.0	1.4	0.4	1.1	0.1
Ulcerative Colitis	0.2	0.3	1.1	0.6	0.2	-0.7	-0.3	-0.2	0.1	1.0	0.4	0.5	0.3
Blood Eosinophil Count	0.1	0.6	1.8	-0.6	-0.6	-0.2	-1.3	-1.1	-0.7	-0.7	-0.5	-1.0	-0.5
Blood Platelet Count	0.4	4.1	8.3	-1.9	-2.9	-1.0	0.8	-2.0	-1.9	-2.1	-2.4	-2.5	-1.9
Blood Red Count	0.6	5.9	9.3	-2.8	-2.5	-1.4	1.6	-2.6	-2.6	-1.4	-3.0	-2.6	-3.0
Blood White Count	0.8	5.7	9.4	-2.6	-3.1	-0.8	0.6	-2.6	-2.3	-2.3	-2.8	-2.8	-2.6
Heel T-Score	0.2	1.6	9.6	-0.6	-1.0	-0.1	-3.1	0.1	-0.5	-1.6	-0.7	-1.2	-0.2
BMI	2.2	12.6	18.0	-4.2	-3.8	-1.6	1.5	-3.7	-4.0	-3.1	-4.1	-3.9	-4.1
Height	0.5	10.5	26.4	-3.4	-3.8	-2.2	-2.6	-5.1	-2.8	-1.6	-2.9	-2.8	-3.7
Waist Hip Ratio (WHR)	1.4	6.3	11.5	-3.4	-2.6	0.4	-0.2	-2.1	-2.1	-3.2	-3.0	-3.2	-2.6
Systolic Blood Pressure	0.9	4.4	8.0	-2.6	-2.0	-1.5	0.6	-2.5	-2.2	-1.1	-2.8	-2.0	-2.6
Smoking Status	1.4	3.3	7.6	-1.8	-1.8	-1.8	0.5	-2.8	-2.5	-0.6	-1.8	-0.4	-2.3
Allergy or Eczema	0.4	1.0	3.2	0.2	0.4	1.6	0.6	1.6	0.3	-1.8	0.2	-0.7	0.7
Cardiovascular Disease	0.5	1.6	7.9	-0.2	0.9	-2.8	2.4	0.3	-0.5	0.7	0.2	0.9	0.0
Hypothyroidism (self reported)	0.2	0.6	2.6	0.1	-0.4	1.6	0.4	0.7	0.1	-1.1	-0.1	-1.0	0.2
Respiratory disease	0.4	1.0	1.9	-1.1	-1.4	-0.2	-0.1	-1.0	-0.8	-1.2	-1.2	-1.0	-1.1
Type 2 Diabetes (T2D) (2018)	0.3	0.6	2.2	-0.4	-0.5	-1.0	1.5	-0.7	-0.6	0.7	-0.3	0.5	-0.7
Lung FEV1/FVC ratio	0.6	2.8	6.0	1.1	1.9	1.8	-1.5	2.5	1.8	-0.2	2.1	0.4	2.0
Lung FVC	0.1	0.3	0.9	0.1	-0.2	-0.8	-1.0	-0.6	-0.3	0.9	0.4	-0.1	-0.2
Neuroticism	6.4	15.3	21.1	-4.6	-4.6	-1.7	-0.3	-3.9	-4.1	-4.1	-4.6	-4.5	-4.2
Chronotype (morning person)	0.1	0.1	0.6	0.1	0.1	-0.4	-0.8	-0.6	-0.1	0.4	-0.3	0.1	-0.2
Hair Pigment	0.1	4.1	7.8	-2.2	-2.8	-0.3	-0.1	-2.2	-1.7	-1.9	-2.4	-2.6	-2.3
Tanning	0.0	0.4	1.3	-0.5	-0.7	-0.7	-1.1	-0.6	-1.0	-0.4	-0.6	-0.2	-0.4
Hand grip strength (left)	1.4	3.6	11.1	-1.3	-2.0	-2.6	0.3	-3.3	-1.9	0.6	-1.8	-0.6	-2.2
Number of treatments/medications taken	0.3	0.5	1.6	-0.9	-0.8	-1.3	0.2	-0.3	-0.5	-0.8	-0.6	-0.0	-0.7
Average weekly spirits intake	0.2	0.3	1.1	-0.4	-0.4	0.2	1.1	-0.3	-0.4	-0.9	-0.4	0.0	-0.4
Sensitivity / hurt feelings	3.3	5.6	9.7	-2.7	-2.5	-3.1	1.4	-2.1	-2.9	-1.5	-2.5	-1.7	-2.6
Frequency of depressed mood in last 2 weeks	6.8	9.5	13.2	-3.6	-3.6	-2.1	1.6	-3.4	-3.6	-2.4	-3.3	-3.0	-3.4
Hearing difficulty/problems: Yes	0.1	0.2	0.8	-0.0	-0.1	0.5	-0.1	0.6	0.1	-0.9	-0.1	-0.2	0.4
Relative age of first facial hair	0.1	0.2	0.7	-0.6	0.0	-0.6	-0.1	-0.6	-0.8	-0.1	-0.4	0.2	-0.5
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.7	-0.8	-0.5	0.3	-0.3	-0.8	-0.7	-0.7	-0.8	-0.6	-0.7
Ever used hormone-replacement therapy (HRT)	1.1	1.4	6.8	0.7	1.2	1.3	-2.6	0.9	1.0	-0.1	0.4	0.6	1.0
Ever had hysterectomy (womb removed)	1.3	1.5	4.0	-1.3	-1.0	0.3	-1.2	-0.8	-1.3	-2.0	-1.1	-1.4	-1.0
Systolic blood pressure, automated reading	1.4	4.1	6.5	-2.4	-1.7	-1.9	1.1	-2.2	-2.4	-1.3	-2.6	-1.5	-2.5
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.0	-0.8	-1.0	-0.4	-0.4	-0.5	0.0	-0.4	-0.6	-0.3	-0.5
Angina	1.0	1.3	6.7	-0.5	-0.2	-2.6	2.0	-0.1	-1.0	0.9	-0.3	0.5	-0.5
Medication for hormone replacement therapy	0.2	0.3	1.1	0.4	0.7	-0.1	0.2	-0.3	0.3	0.7	0.4	1.0	0.3
Vitamin and mineral supplements	0.2	0.3	1.2	0.3	-0.0	-0.6	1.1	-0.1	0.3	0.8	0.6	0.2	0.2
Supplements: Zinc	0.5	0.6	3.3	0.2	0.2	1.8	-1.1	0.2	0.7	-0.0	-0.5	-0.4	0.2
Medication: Co-codamol	0.3	0.4	0.8	-0.8	-0.9	-0.7	-0.3	-0.4	-0.5	-0.1	-0.6	-0.7	-0.7
Medication: Metformin	0.1	0.1	0.9	-0.2	-0.3	0.0	0.9	0.6	-0.1	-0.3	0.1	-0.2	-0.0
Diabetes (father)	0.7	0.8	1.6	1.2	1.2	0.9	-1.0	0.7	1.0	0.3	1.0	0.4	0.9
Diabetes (mother)	0.1	0.1	0.3	-0.3	-0.2	0.1	0.4	0.4	-0.2	-0.5	-0.1	-0.3	-0.1
Severe depression (siblings)	1.8	2.0	3.1	-1.6	-1.4	-0.8	0.4	-1.5	-1.6	-1.4	-1.8	-1.3	-1.6
Pack years adult smoking proportion	0.6	0.9	3.6	0.2	0.5	1.9	-0.4	1.2	1.2	-0.9	0.2	-0.5	0.8
Impedance of leg (right)	0.7	3.6	7.0	2.2	2.0	0.6	-1.8	1.4	2.1	1.7	2.1	2.6	1.9
Leg fat-free mass (left)	1.9	9.8	15.2	-3.6	-3.5	-2.2	1.2	-3.9	-3.3	-1.8	-3.4	-3.5	-3.6
Trunk fat percentage	4.1	16.4	29.1	-5.4	-4.3	-2.2	0.9	-4.2	-4.3	-3.6	-4.4	-4.5	-4.8
Hand grip strength (right)	0.4	1.1	4.3	-0.4	-0.8	-2.1	0.1	-1.6	-0.8	0.9	-0.5	0.4	-1.1
Townsend deprivation index at recruitment	0.6	0.9	1.7	-1.3	-0.9	-0.1	0.3	-1.1	-0.9	-0.9	-1.0	-1.2	-1.2
Current tobacco smoking	1.6	2.6	4.2	-1.6	-2.0	-1.0	0.8	-2.1	-2.0	-1.1	-1.6	-1.2	-2.0
Average weekly fortified wine intake	2.5	2.9	5.1	1.9	2.0	-0.2	0.8	1.6	1.4	1.9	2.1	2.2	1.9
Maternal smoking around birth	0.3	0.4	1.1	-0.4	-0.6	0.3	0.7	-1.0	-0.8	-0.2	-0.3	-0.4	-0.8
Fed-up feelings	14.8	26.9	39.2	-6.3	-6.1	-3.3	1.6	-5.5	-5.8	-4.5	-5.8	-5.3	-5.9
Frequency of unenthusiasm / disinterest in last 2 weeks	5.8	7.7	11.2	-3.3	-3.3	-1.1	0.8	-2.9	-3.1	-2.4	-3.0	-3.3	-3.0
Relative age voice broke	0.1	0.1	0.6	0.3	0.3	-0.5	-0.2	-0.1	-0.4	0.2	0.3	0.8	0.2
Taking other prescription medications	0.1	0.1	0.5	-0.1	0.1	-0.7	0.3	0.4	-0.0	0.1	0.0	0.4	0.0
Age when periods started (menarche)	0.5	1.2	5.9	0.4	0.6	2.4	-1.2	0.9	1.5	-0.5	0.3	-0.4	1.0
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.8	-0.4	-0.3	-0.9	-0.3	0.2	-0.5	-0.7	-0.2	-0.2	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.0	1.2	0.3	-1.1	0.2	0.4	0.7	1.4	1.0	1.2	0.8
Tinnitus: Yes, but not now, but have in the past	0.2	0.3	1.0	-0.6	-0.2	0.4	-0.6	-0.2	-0.4	-0.5	0.0	-1.0	-0.3
Qualifications: CSEs or equivalent	0.5	0.7	4.1	-0.4	-0.3	-0.7	2.0	-0.4	-1.1	0.1	-0.5	0.1	-0.9
Serious illness, injury or assault to yourself	0.9	1.1	2.6	-1.6	-1.0	-1.0	-0.3	-1.2	-1.2	-0.7	-0.8	-0.9	-1.2
High blood pressure	0.7	2.0	12.4	-0.7	-0.1	-3.5	1.9	-0.8	-0.9	0.8	-0.4	0.8	-0.7
Hayfever, allergic rhinitis or eczema	0.6	1.2	4.5	0.2	0.3	2.1	-0.5	1.2	0.4	-2.0	0.1	-1.2	0.7
Multivitamins +/- minerals	1.1	1.3	3.4	-1.2	-1.2	0.8	-1.0	-0.7	-0.7	-1.8	-1.5	-1.1	-1.0
Stomach or abdominal pain in last month	1.0	1.3	2.2	-1.3	-1.4	-0.2	1.0	-1.5	-0.7	-0.7	-1.0	-1.5	-1.2
Supplements: Glucosamine	1.8	2.3	3.9	1.8	1.8	0.2	-0.5	1.8	1.6	1.0	1.6	2.0	1.7
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.7	0.1	0.4	0.8	0.5	0.3	0.7	-0.2	0.2	0.4	0.6
Medication: Atenolol	0.8	1.0	3.2	-1.3	-1.1	-0.8	1.8	-0.9	-0.6	-0.6	-0.8	-0.8	-1.0
Medication: Levothyroxine sodium	0.4	0.6	3.3	-0.6	-0.2	1.8	0.1	0.3	-0.0	-1.2	-0.3	-0.9	-0.1
Sitting height	0.1	0.5	1.1	0.4	-0.4	-1.0	-1.0	-0.8	0.5	1.0	0.5	-0.2	0.1
Chronic bronchitis/emphysema (father)	2.4	2.9	4.4	2.0	1.6	0.6	0.3	1.8	1.9	1.9	2.1	1.8	1.9
High blood pressure (mother)	0.3	0.4	1.7	-0.2	-0.2	1.3	-0.7	0.3	0.2	-1.3	-0.1	-0.5	-0.0
Body mass index (BMI)	4.4	18.6	26.3	-5.1	-4.7	-2.7	2.2	-4.7	-4.9	-3.4	-4.7	-4.6	-5.1
Impedance of leg (left)	0.7	3.5	5.8	2.0	1.8	0.9	-2.0	1.5	2.2	1.5	2.0	2.4	1.9
Leg predicted mass (left)	2.0	10.5	16.1	-3.7	-3.7	-2.2	1.2	-4.0	-3.4	-2.0	-3.5	-3.6	-3.8
Trunk fat mass	4.6	19.9	32.0	-5.7	-4.8	-2.7	1.0	-5.0	-4.7	-3.6	-4.8	-4.8	-5.3
Waist circumference	6.5	23.9	36.0	-6.0	-5.3	-2.5	1.6	-5.2	-5.3	-4.2	-5.5	-5.4	-5.8
Number of incorrect matches in round	1.2	2.0	7.4	-1.6	-1.3	0.8	-1.0	-0.2	-1.0	-2.7	-1.0	-1.8	-1.0
Past tobacco smoking	0.4	0.8	1.6	0.6	0.6	0.8	-0.9	1.3	1.2	0.1	1.2	-0.4	1.1
Alcohol usually taken with meals	2.2	3.5	14.9	0.3	0.3	3.9	-2.8	1.7	1.8	-2.0	0.3	-1.0	1.1
Nervous feelings	2.3	4.3	9.7	-2.3	-2.4	0.6	-0.7	-1.2	-1.4	-3.1	-2.4	-3.1	-1.7
Frequency of tenseness / restlessness in last 2 weeks	2.2	3.5	8.2	-2.0	-2.0	0.9	-1.1	-1.1	-1.4	-2.9	-1.8	-2.8	-1.4
Hearing difficulty/problems with background noise	0.3	0.5	2.0	-0.3	-0.8	0.7	-0.5	0.0	-0.0	-1.4	-0.8	-0.7	-0.1
Hair/balding pattern: Pattern 2	0.4	0.5	1.3	0.8	0.9	0.6	1.1	1.2	0.4	-0.1	0.6	0.4	0.7
Had menopause	1.1	1.4	7.3	0.1	1.2	1.2	-2.7	1.1	0.8	-0.8	0.5	0.1	0.8
Had other major operations	2.6	3.2	5.2	-2.1	-2.1	-0.4	0.7	-1.8	-1.9	-2.0	-1.7	-2.3	-2.0
Forced vital capacity (FVC)	0.1	0.5	1.7	-0.1	-0.3	-0.9	-1.3	-1.2	-0.0	0.9	0.4	-0.0	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	1.8	0.2	-0.1	-1.3	-0.5	-0.1	0.2	0.5	0.5	0.1	0.3
Ever unenthusiastic/disinterested for a whole week	1.6	2.0	4.2	-1.4	-1.6	0.5	0.4	-1.7	-1.1	-0.9	-1.8	-2.0	-1.4
Qualifications: None of the above	4.2	9.0	13.2	-3.6	-3.3	-3.2	1.6	-3.3	-3.4	-1.9	-3.3	-2.0	-3.6
Financial difficulties in last 2 years	2.9	3.8	7.3	-2.1	-2.0	-1.1	0.1	-2.7	-2.6	-1.6	-2.1	-1.5	-2.3
Mouth/teeth dental problems	1.1	1.7	2.3	1.5	1.5	0.4	0.2	1.5	1.4	1.2	1.5	1.4	1.5
Heart attack	0.4	0.5	0.9	-1.0	-0.9	-0.5	0.7	-0.8	-0.7	-0.5	-0.7	-0.5	-0.9
Allergy	0.4	0.9	3.8	0.5	0.6	-1.2	0.1	0.1	0.4	1.9	0.7	1.4	0.3
Pain all over the body in last month	0.3	0.3	0.7	0.2	0.6	-0.2	-0.8	0.3	0.6	0.5	0.6	0.6	0.6
Diabetes (self-reported)	0.2	0.4	1.5	-0.5	-0.5	-1.1	1.2	-0.1	-0.5	0.0	-0.2	0.2	-0.5
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.4	-0.7	-0.8	-0.4	0.1	-0.5	-0.8	-1.2	-0.4	-0.8	-0.7
Medication: Ramipril	1.2	1.6	3.9	-1.4	-1.3	-2.0	-0.0	-1.2	-1.5	-0.8	-0.9	-1.2	-1.4
Medication: Simvastatin	0.7	1.0	1.7	-1.3	-0.8	-1.3	0.8	-0.9	-1.3	-0.6	-1.2	-0.3	-1.1
Fluid intelligence score	2.2	4.5	7.0	2.6	2.3	1.6	-1.6	2.5	2.5	1.1	2.2	1.7	2.6
Illnesses of siblings	1.7	2.4	3.4	1.8	1.8	1.2	-1.4	1.5	1.4	1.0	1.7	1.4	1.9
Neuroticism score	7.8	16.4	23.8	-4.7	-4.9	-2.2	-0.1	-4.1	-4.3	-3.9	-4.7	-4.6	-4.3
Weight	3.9	19.1	28.3	-5.1	-5.0	-2.9	1.2	-5.3	-4.7	-3.0	-4.8	-4.7	-5.2
Impedance of arm (right)	0.5	2.2	4.1	1.1	1.4	2.0	-1.2	1.8	1.8	-0.2	1.7	1.1	1.6
Arm fat percentage (right)	4.3	16.8	26.3	-5.1	-4.4	-2.0	2.0	-4.2	-4.5	-3.8	-4.5	-4.4	-4.8
Trunk fat-free mass	1.6	9.0	17.4	-2.9	-3.7	-2.6	0.6	-4.2	-3.1	-1.4	-3.3	-3.0	-3.5
Hip circumference	2.9	12.6	17.8	-4.0	-4.0	-2.3	1.3	-4.2	-3.9	-2.5	-3.8	-3.9	-4.2
Time employed in main current job	0.1	0.1	0.5	-0.1	0.1	0.3	-0.3	0.7	0.4	-0.5	0.3	-0.1	0.2
Alcohol intake versus 10 years previously	1.5	2.3	3.6	-1.7	-1.5	-1.8	0.9	-1.7	-1.9	-0.6	-1.0	-1.5	-1.8
Father’s age at death	0.7	1.0	3.2	0.7	1.0	-0.4	-1.6	0.1	0.5	1.2	0.5	1.8	0.7
Worrier / anxious feelings	3.2	6.1	10.6	-2.8	-2.9	-1.4	0.1	-2.2	-2.5	-2.7	-2.8	-3.3	-2.5
Frequency of tiredness / lethargy in last 2 weeks	4.3	6.9	10.0	-3.2	-3.0	-2.2	1.5	-3.1	-2.9	-1.1	-2.8	-2.4	-3.1
Falls in the last year	0.9	1.3	5.1	-1.6	-1.1	0.9	-0.4	-0.5	-0.2	-2.3	-1.0	-1.0	-0.8
Hair/balding pattern: Pattern 3	0.4	0.5	1.3	-0.6	-1.1	0.9	-0.3	-0.2	0.1	-1.0	-0.6	-1.1	-0.3
Number of live births	2.9	4.1	12.7	-1.3	-1.8	-3.6	2.1	-2.5	-2.6	0.6	-1.4	0.1	-2.0
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	3.3	0.4	0.4	0.4	-1.8	-0.2	0.7	0.7	0.8	-0.1	0.5
Pulse rate	0.2	0.3	1.0	0.2	-0.3	-1.0	0.2	-0.7	-0.6	0.8	-0.6	0.0	-0.3
Happiness	0.2	0.2	0.6	0.1	0.4	0.7	-0.8	0.3	0.4	0.2	0.5	-0.1	0.4
Noisy workplace	3.3	4.1	8.8	-2.5	-2.3	0.0	-1.2	-1.9	-1.6	-2.4	-1.9	-3.0	-2.0
Qualifications: A levels/AS levels or equivalent	2.1	4.6	17.0	1.3	1.5	4.1	-1.8	2.6	2.5	-1.2	1.7	-0.4	2.2
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	4.9	-0.2	0.2	2.2	-0.6	-0.0	0.2	-0.9	-0.3	-0.6	0.0
Mouth/teeth dental problems: Dentures	0.2	0.4	2.1	-0.2	-0.1	-1.4	0.2	-0.5	-0.7	0.6	-0.2	0.6	-0.4
Asthma	0.1	0.2	0.5	-0.3	-0.3	0.4	0.5	-0.7	-0.1	-0.4	-0.4	-0.4	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.7	0.8	0.8	-0.2	-0.8	1.3	0.8	-0.0	0.9	0.6	1.1
Medication: Cholesterol lowering	1.4	2.2	3.6	-1.7	-1.5	-1.6	1.0	-1.3	-1.9	-1.5	-1.4	-1.1	-1.6
Depression (self-reported)	0.1	0.1	0.2	0.0	-0.1	-0.4	-0.3	-0.1	0.2	0.4	0.2	0.1	0.2
Medication: Lansoprazole	0.1	0.1	0.4	-0.5	0.1	-0.3	-0.7	0.3	0.2	-0.4	-0.2	0.0	-0.1
Prospective memory result	4.1	5.1	8.4	-2.6	-2.7	-0.7	0.2	-2.2	-2.6	-2.0	-2.9	-2.2	-2.8
Lung cancer (father)	1.0	1.2	2.5	0.8	1.6	1.0	-1.4	1.3	0.8	0.1	1.0	1.1	1.2
Illnesses of mother	0.1	0.1	0.5	0.4	0.3	-0.5	-0.1	-0.3	-0.3	0.7	0.2	0.3	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	5.1	0.8	0.8	0.8	-2.3	0.2	1.4	0.9	1.1	0.1	1.0
Pulse wave Arterial Stiffness index	0.0	0.0	0.1	-0.1	-0.1	-0.1	-0.3	-0.1	0.4	-0.2	0.1	-0.2	0.2
Impedance of arm (left)	0.8	3.9	6.8	1.7	2.4	1.7	-1.3	2.6	2.2	0.6	2.4	1.8	2.2
Arm fat mass (right)	5.3	22.0	31.9	-5.6	-5.2	-2.5	1.8	-5.2	-5.2	-3.9	-5.2	-5.1	-5.5
Trunk predicted mass	1.7	9.5	18.1	-3.0	-3.8	-2.6	0.5	-4.3	-3.2	-1.5	-3.4	-3.1	-3.6
Standing height	0.2	1.9	6.2	-0.9	-1.7	-1.3	-1.8	-2.5	-0.6	0.1	-1.1	-1.0	-1.3
Length of working week for main job	1.7	1.9	4.5	1.6	1.9	-0.1	0.1	1.2	0.8	1.5	2.1	1.2	1.5
Exposure to tobacco smoke at home	0.2	0.2	0.4	0.4	0.2	0.4	0.4	0.6	0.1	0.7	-0.2	0.7	0.2
Breastfed as a baby	1.7	2.1	3.3	1.3	1.6	0.5	-1.8	1.4	1.6	0.7	1.6	1.6	1.6
Tense / ‘highly strung’	1.1	1.9	3.8	-1.4	-1.8	-0.6	-0.8	-1.4	-1.0	-1.0	-1.9	-1.9	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.3	3.9	-0.7	-1.0	2.0	-1.6	-1.1	-0.2	-1.1	-0.8	-1.3	-0.5
Hair/balding pattern: Pattern 4	0.3	0.8	3.1	0.2	0.1	-1.8	0.1	-0.9	-0.6	1.4	0.3	1.1	-0.3
Birth weight of first child	0.6	1.1	3.6	0.8	0.9	-0.6	1.9	0.7	0.8	1.2	0.9	1.4	0.7
Peak expiratory flow (PEF)	0.2	0.5	3.0	0.3	0.4	0.8	-1.7	-0.3	0.4	0.1	0.5	-0.2	0.3
Pulse wave reflection index	0.2	0.3	0.8	0.4	0.2	0.2	0.5	0.9	0.9	-0.2	0.7	-0.1	0.7
Ever highly irritable/argumentative for 2 days	1.9	2.3	4.2	-1.8	-1.9	0.0	0.6	-1.1	-1.5	-1.6	-1.9	-2.1	-1.6
Loud music exposure frequency	0.4	0.5	1.2	0.7	0.6	-0.9	-0.2	0.2	0.5	1.1	0.6	0.8	0.5
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	6.1	0.7	0.9	2.5	-1.1	1.9	1.2	-0.9	0.9	-0.9	1.1
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	4.8	-0.3	-0.3	1.2	-2.2	0.1	0.6	-1.0	0.3	-0.9	0.3
Blood clot in the leg (DVT)	0.4	0.6	0.9	-1.0	-0.6	0.3	0.3	-1.0	-0.8	-0.8	-0.7	-0.9	-0.7
Medication: Paracetamol	0.2	0.4	1.4	-1.1	-0.2	-1.2	-0.0	-0.2	-0.6	-0.5	-0.2	-0.6	-0.5
Headache pain in last month	1.0	1.6	3.9	0.6	1.0	-2.0	1.8	0.8	0.2	1.6	1.5	1.4	0.6
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	6.7	1.5	1.2	2.6	-1.3	1.4	1.7	0.7	1.1	0.6	1.5
Glaucoma (self-reported)	0.4	0.5	2.0	-0.6	-0.7	-1.4	-0.2	-0.9	-0.9	-0.0	-0.5	-0.1	-0.7
Gout (self-reported)	0.1	0.1	0.2	0.4	0.3	0.1	-0.3	0.2	0.4	-0.2	0.3	0.1	0.4
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.0	-0.8	-0.8	1.1	0.6	-0.0	-0.6	-1.4	-0.6	-1.4	-0.6
Medication: Amlodipine	1.2	1.6	3.2	1.6	1.0	-0.8	-0.4	1.1	1.3	1.6	1.3	1.8	1.2
Medication: Ventolin 100micrograms inhaler	0.8	1.0	4.5	-1.0	-0.7	-1.3	2.1	-0.4	-0.8	-0.2	-0.7	-0.7	-1.0
Birth weight	0.4	0.8	3.4	-0.9	-0.7	-1.9	-0.1	-1.2	-0.8	-0.1	-1.0	0.1	-0.8
Chronic bronchitis/emphysema (mother)	0.4	0.4	2.3	-0.2	-0.3	1.5	-0.8	-0.2	0.1	-1.0	-0.5	-0.4	0.0
High blood pressure (siblings)	0.5	0.8	1.5	-0.9	-1.2	-1.2	0.7	-1.2	-0.8	-0.2	-0.7	-0.3	-1.0
Forced vital capacity (FVC), Best measure	0.2	0.7	2.5	0.5	0.2	-0.8	-1.6	-0.6	0.6	1.3	0.9	0.3	0.4
Body fat percentage	4.1	16.1	26.7	-5.2	-4.3	-2.5	1.3	-4.3	-4.4	-3.2	-4.4	-4.2	-4.8
Leg fat percentage (right)	4.3	15.6	23.1	-4.8	-4.2	-3.0	1.5	-4.6	-4.6	-2.8	-4.4	-3.6	-4.8
Arm fat-free mass (right)	1.8	9.1	16.5	-3.2	-3.5	-2.7	0.7	-4.1	-3.2	-1.3	-3.3	-3.0	-3.5
Exposure to tobacco smoke outside home	0.5	0.6	2.1	-0.5	-0.2	1.4	-1.4	0.5	0.1	-0.9	-0.1	-0.7	-0.2
Comparative body size at age 10	0.5	1.3	2.1	-1.3	-1.2	-0.9	0.8	-1.3	-1.4	-0.7	-0.9	-1.1	-1.5
Number of full brothers	2.1	2.7	4.0	-1.9	-1.8	-1.1	1.9	-1.8	-2.0	-0.6	-1.4	-1.4	-1.9
Worry too long after embarrassment	3.3	5.6	8.5	-2.9	-2.4	-2.0	0.0	-2.1	-2.8	-2.6	-2.5	-2.3	-2.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	3.4	-0.1	-0.3	1.8	-0.6	-0.6	0.5	-0.2	-0.2	-0.9	0.0
Wheeze or whistling in the chest in last year	1.8	3.3	5.4	-2.1	-2.1	-0.7	0.8	-2.3	-1.9	-1.1	-2.0	-2.0	-2.2
Number of children fathered	1.5	1.7	4.0	-1.2	-1.5	0.1	-1.6	-0.9	-0.9	-1.5	-1.5	-2.0	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	8.6	10.1	16.1	3.5	3.7	2.7	-1.7	4.0	3.8	1.9	3.3	2.1	3.8
Age at first live birth	1.1	2.0	3.2	1.5	1.5	1.3	-1.0	1.7	1.8	0.3	1.7	0.9	1.8
Pulse wave peak to peak time	0.0	0.0	0.1	0.2	0.1	0.1	-0.1	-0.0	-0.2	0.3	0.0	0.3	-0.1
Health satisfaction	2.8	3.7	5.5	-2.0	-2.2	-1.7	1.0	-2.3	-2.3	-1.0	-2.1	-1.8	-2.2
Shortness of breath walking on level ground	2.5	3.0	6.2	-1.6	-1.6	-1.6	2.5	-1.8	-2.0	-0.1	-1.9	-1.3	-1.9
Qualifications: College or University degree	3.2	10.0	28.0	2.6	2.9	5.3	-3.3	3.6	3.7	-0.7	2.6	0.3	3.5
Eye problems/disorders: None of the above	0.7	0.8	1.5	1.0	1.2	0.1	0.0	1.2	0.9	0.9	0.8	0.9	1.0
Mouth/teeth dental problems: Loose teeth	0.4	0.5	2.6	0.4	0.6	0.4	-1.6	0.4	0.6	-0.3	0.5	0.2	0.8
Emphysema/chronic bronchitis	0.2	0.3	0.9	0.1	0.9	0.7	0.3	0.5	0.5	-0.0	0.5	0.1	0.5
Medication for pain relief, constipation, heartburn	0.3	0.6	2.3	1.1	0.4	1.5	-0.1	0.3	0.7	0.7	0.6	0.4	0.6
Neck or shoulder pain in last month	1.1	1.5	3.5	-1.2	-1.3	-1.9	0.3	-1.5	-1.9	-0.5	-0.8	-0.2	-1.4
Medication: Blood pressure	0.8	1.5	8.2	-0.6	-0.7	-2.9	1.3	-1.2	-1.1	0.6	-0.3	0.3	-0.9
Angina (self-reported)	1.3	1.7	8.2	-0.7	-0.5	-2.9	2.1	-0.4	-1.2	0.9	-0.5	0.5	-0.8
Migraine (self-reported)	0.3	0.4	1.5	0.5	0.3	-0.8	0.2	-0.2	0.3	1.2	0.3	1.2	0.1
Medication: Ibuprofen	0.0	0.0	0.3	-0.1	-0.0	-0.3	-0.0	0.2	0.0	-0.6	-0.1	-0.0	0.1
Medication: Allopurinol	0.1	0.2	0.5	0.2	-0.0	0.5	-0.7	0.7	0.2	-0.5	-0.0	-0.6	0.2
Medication: Omeprazole	3.6	4.3	7.0	-2.6	-2.3	-1.8	0.4	-2.1	-2.3	-1.5	-2.2	-2.2	-2.4
Medication: Seretide 50 evohaler	0.5	0.5	2.7	-0.4	0.1	-1.2	1.6	-0.1	-0.4	0.6	-0.0	-0.3	-0.4
Mean time to correctly identify matches	0.5	0.9	3.0	0.6	0.9	-1.7	0.4	0.2	0.3	1.5	1.0	1.0	0.6
Heart disease (mother)	0.5	0.6	1.2	-1.1	-0.7	-0.5	0.7	-0.9	-0.7	-0.2	-0.9	-0.5	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	2.0	1.4	0.9	-0.1	0.3	0.9	0.7	1.0	1.3	1.4	1.1
Whole body fat mass	4.4	18.6	28.8	-5.4	-4.7	-2.9	1.2	-4.9	-4.7	-3.3	-4.7	-4.5	-5.2
Leg fat mass (right)	5.0	19.3	27.9	-5.3	-4.8	-3.1	1.5	-5.2	-4.9	-3.1	-4.8	-4.4	-5.3
Arm predicted mass (right)	1.9	9.7	17.2	-3.3	-3.6	-2.7	0.7	-4.2	-3.3	-1.5	-3.5	-3.2	-3.6
Pulse rate, automated reading	0.5	1.7	3.1	1.8	1.6	-0.5	0.3	1.7	1.1	1.5	1.3	1.3	1.5
Alcohol intake frequency.	3.7	8.7	12.8	-3.4	-3.5	-2.9	1.6	-3.2	-3.6	-2.0	-2.3	-2.7	-3.4
Comparative height size at age 10	1.4	7.4	14.7	-2.8	-3.4	-3.4	0.3	-3.8	-2.9	-0.8	-2.4	-2.0	-3.3
Number of full sisters	0.8	1.0	1.9	-1.1	-1.3	-0.6	0.1	-1.4	-0.8	-0.7	-1.3	-0.9	-1.2
Suffer from ‘nerves’	1.0	1.6	3.0	-1.4	-1.7	-0.1	-1.4	-0.9	-0.7	-1.7	-1.2	-1.6	-1.0
Overall health rating	5.2	11.1	15.8	-3.9	-3.4	-3.7	2.9	-3.8	-4.0	-1.0	-3.4	-2.3	-3.9
Chest pain or discomfort	0.2	0.2	0.9	0.4	-0.1	-0.8	0.6	0.1	0.1	1.0	-0.1	0.4	-0.0
Had major operations	1.1	1.3	6.5	0.5	0.3	2.5	-1.7	1.1	1.1	-0.6	0.4	-0.4	0.8
Age at last live birth	0.1	0.1	0.6	0.0	-0.3	0.1	0.2	0.1	-0.3	-0.8	0.1	-0.2	0.0
Family relationship satisfaction	0.4	0.6	2.1	-0.8	-0.8	0.0	-0.8	-1.4	-0.5	0.1	-0.5	-0.7	-0.6
Leg pain on walking	4.2	5.3	8.0	-2.6	-2.5	-1.9	2.3	-2.2	-2.8	-1.4	-2.1	-2.1	-2.6
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	4.0	-1.1	-0.3	-1.8	2.0	-0.5	-1.5	-0.3	-0.3	-0.6	-0.9
Commuting to job workplace: Car/motor vehicle	0.2	0.2	1.1	0.0	-0.6	1.0	0.2	-0.2	-0.1	-0.6	-0.1	-0.4	-0.3
Illness, injury, bereavement, stress in last 2 years	3.7	4.5	9.3	2.2	2.2	0.4	-0.3	3.0	2.6	1.3	2.6	2.1	2.4
Medication: Aspirin	0.5	0.7	2.9	-0.8	-1.0	-1.7	0.4	-0.7	-0.6	-0.4	-0.5	-0.0	-0.9
Supplements: Vitamin C	0.2	0.3	0.7	-0.5	-0.2	0.6	-0.7	-0.2	-0.4	-0.5	-0.5	-0.9	-0.4
Knee pain experienced in last month	2.1	3.3	5.7	-2.1	-2.0	-1.3	0.8	-2.4	-2.2	-1.0	-2.0	-1.4	-2.2
Hypertension (Self-reported)	0.7	2.1	13.2	-0.4	0.1	-3.6	1.8	-0.6	-0.9	1.0	-0.2	1.1	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	2.6	-1.1	-0.8	-0.3	-0.4	0.0	-0.7	-1.6	-1.0	-1.5	-0.6
Illnesses of father: Heart disease	0.2	0.3	0.9	-0.7	-0.2	0.7	0.2	0.6	-0.0	-0.9	-0.4	-0.6	-0.2
Illnesses of siblings: Diabetes	3.4	4.1	6.3	-2.5	-2.3	-0.9	0.7	-2.2	-2.3	-1.6	-2.4	-1.9	-2.5
Smoking status: Previous	0.5	0.7	1.8	-0.5	-0.4	-1.0	0.6	-1.3	-1.0	0.3	-1.1	0.5	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	2.7	0.9	0.6	-0.7	-0.2	-0.2	0.8	1.7	1.2	0.8	0.7
Whole body fat-free mass	1.9	10.6	18.2	-3.5	-3.9	-2.6	0.9	-4.3	-3.4	-1.7	-3.6	-3.5	-3.8
Leg fat-free mass (right)	1.6	8.7	12.6	-3.4	-3.4	-1.9	1.1	-3.5	-3.0	-1.8	-3.2	-3.6	-3.4
Arm fat percentage (left)	3.8	15.2	24.6	-5.0	-4.1	-2.2	1.9	-3.9	-4.4	-3.3	-4.2	-4.2	-4.6
Average weekly red wine intake	1.2	1.8	5.2	1.4	1.0	2.3	-0.9	1.4	1.7	0.4	1.0	-0.1	1.7
Handedness (chirality/laterality): Left-handed	1.0	1.2	3.1	1.2	0.8	-1.0	1.6	-0.2	-0.1	1.8	-0.0	1.7	0.4
Mood swings	9.5	17.2	24.4	-4.7	-4.9	-2.0	0.4	-4.6	-4.3	-3.5	-4.8	-4.9	-4.6
Loneliness, isolation	2.8	3.9	8.1	-2.1	-2.8	0.8	-0.1	-1.6	-1.5	-2.1	-2.2	-2.8	-2.1
Long-standing illness, disability or infirmity	2.1	3.1	5.1	-1.9	-1.9	-1.0	2.3	-2.0	-1.8	-1.0	-1.8	-1.4	-2.0
Ever had bowel cancer screening	0.8	0.9	1.8	1.1	1.1	0.0	-0.2	0.8	0.8	1.4	1.3	0.9	1.1
Diabetes diagnosed by doctor	0.2	0.3	1.1	-0.5	-0.3	-0.9	1.0	-0.3	-0.5	0.2	-0.2	0.3	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.2	1.8	-1.2	-1.1	-0.5	0.1	-1.3	-1.3	-1.2	-1.2	-1.3	-1.1
Friendships satisfaction	0.9	1.1	3.4	-0.9	-1.0	0.8	-1.1	-0.3	-0.3	-1.8	-0.4	-1.8	-0.5
Qualifications: nursing, teaching	3.9	6.1	11.0	2.6	2.0	3.3	-3.0	3.0	3.1	0.1	2.0	0.7	2.8
Commuting to job workplace: Walk	1.4	1.5	2.6	1.0	1.6	-0.8	-0.7	1.1	1.1	1.6	1.6	0.8	1.3
Eye problems/disorders: Cataract	1.0	1.1	2.9	-1.3	-1.1	0.0	0.9	-1.7	-1.0	-0.5	-1.0	-0.8	-1.3
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.5	-0.1	-0.6	1.2	-0.1	-0.6	-0.3	-1.0	-0.5	-1.2	-0.3
Medication for cholesterol	0.2	0.3	1.0	0.4	0.1	0.8	-1.0	0.5	0.2	-0.6	0.2	-0.4	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	3.3	1.5	1.0	-0.7	1.4	0.7	0.2	1.8	1.1	1.8	1.0
Back pain experienced in last month	1.5	2.3	4.3	-1.1	-1.7	-2.1	1.7	-1.9	-1.9	0.3	-1.0	-0.5	-1.8
Mineral and other dietary supplements	0.9	1.2	2.1	-1.1	-1.3	-0.7	1.1	-1.3	-1.1	-0.2	-0.7	-1.5	-1.3
Breast cancer (self-reported)	0.1	0.1	0.4	-0.6	-0.1	-0.5	-0.2	0.0	-0.2	-0.3	-0.2	0.1	-0.2
Asthma (self-reported)	0.2	0.3	0.7	-0.6	-0.6	0.2	0.6	-0.8	-0.3	-0.5	-0.5	-0.6	-0.6
Osteoporosis (self-reported)	0.2	0.3	0.8	-0.1	-0.6	-0.3	0.5	-0.8	-0.5	0.2	-0.9	-0.1	-0.4
Osteoarthritis (self-reported)	0.9	1.1	3.8	-1.1	-0.2	-1.9	1.2	-0.8	-1.6	-0.2	-0.8	0.4	-1.0
Medication: Aspirin	0.3	0.4	2.2	-0.2	-0.4	-1.5	0.8	-0.1	-0.1	0.2	0.0	0.8	-0.4
Medication: Gliclazide	1.0	1.2	3.6	0.8	1.0	1.0	0.3	1.9	1.3	0.1	1.4	0.5	1.2
Illnesses of father: None of the above (group 1)	1.1	1.3	3.6	-0.7	-1.1	-1.2	0.1	-1.9	-1.8	-0.2	-1.0	-0.5	-1.4
Smoking status: Current	1.6	2.6	4.6	-1.6	-1.9	-1.1	0.9	-2.0	-2.1	-1.1	-1.6	-1.1	-2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	2.0	0.8	0.8	-0.1	-1.4	0.2	0.4	0.9	1.2	0.5	0.7
Whole body water mass	2.0	11.6	19.9	-3.6	-4.0	-2.5	0.8	-4.5	-3.5	-2.0	-3.8	-3.7	-3.9
Leg predicted mass (right)	1.7	9.2	13.7	-3.5	-3.5	-1.8	1.0	-3.6	-3.0	-2.0	-3.3	-3.7	-3.5
Arm fat mass (left)	4.9	20.2	29.3	-5.4	-4.8	-2.9	1.9	-5.1	-5.1	-3.3	-4.9	-4.7	-5.3
Number of self-reported non-cancer illnesses	0.8	1.5	3.4	-1.4	-1.1	-1.8	0.5	-1.4	-1.2	-0.9	-1.3	-0.3	-1.2
Average weekly champagne plus white wine intake	2.3	3.2	8.4	1.1	1.0	2.9	-2.3	2.2	2.1	-1.2	1.3	-0.4	1.9
Miserableness	9.5	16.4	22.2	-4.7	-4.6	-3.6	1.4	-4.5	-4.7	-2.7	-4.6	-3.8	-4.6
Guilty feelings	5.0	7.5	12.3	-3.1	-3.3	-0.3	-0.0	-2.2	-2.9	-3.5	-3.0	-3.4	-2.8
Wears glasses or contact lenses	0.2	0.3	0.6	-0.4	-0.6	-0.1	0.4	-0.1	-0.8	-0.7	-0.6	-0.5	-0.5
Ever taken oral contraceptive pill	1.5	1.7	6.4	1.2	1.4	2.5	-1.3	0.8	1.5	0.8	0.7	0.1	1.3
Hearing aid user	0.2	0.2	1.2	-0.0	-0.4	-1.1	0.8	-0.6	-0.2	0.0	-0.0	0.1	-0.1
Mother’s age at death	0.0	0.0	0.2	0.1	-0.1	0.1	0.3	0.4	0.1	0.1	-0.2	0.0	-0.0
Financial situation satisfaction	0.8	1.0	2.2	-1.0	-1.0	-0.8	0.0	-1.5	-1.4	-0.1	-1.1	-0.7	-1.3
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.4	-0.1	-0.6	-0.3	0.6	-0.3	-0.3	-0.4	-0.6	0.3	-0.4
Commuting to job workplace: Public transport	0.2	0.3	0.8	0.4	0.6	0.6	-0.5	0.4	0.9	-0.0	0.3	0.1	0.8
Eye problems/disorders: Glaucoma	0.1	0.2	0.6	-0.0	0.1	-0.8	-0.7	-0.0	-0.1	0.5	0.5	0.3	0.1
Medication: Blood pressure	0.3	0.6	2.8	-0.4	-0.1	-1.7	1.5	0.1	-0.4	0.6	-0.1	0.5	-0.4
Pain type(s) experienced in last month: Hip pain	0.4	0.5	2.1	0.0	0.4	-1.3	-0.4	-0.2	-0.1	0.8	0.4	1.4	-0.0
Supplements: Fish oil (including cod liver oil)	0.3	0.4	2.1	-0.0	-0.2	0.7	-1.5	-0.2	-0.0	-1.1	-0.6	0.4	0.1
High cholesterol (Self-reported)	0.7	1.2	3.1	0.6	1.3	-1.1	0.7	1.1	0.6	0.9	1.2	1.8	0.9
Medication: Bendroflumethiazide	0.3	0.5	2.0	0.1	0.2	-1.4	1.2	0.1	0.1	0.7	0.5	0.6	0.0
Medication: Paracetamol	0.7	1.1	2.5	-1.6	-1.0	-0.8	0.4	-1.1	-1.2	-1.0	-0.9	-0.7	-1.2
Medication: Lisinopril	0.6	0.7	1.3	1.1	1.1	-0.3	-0.3	1.1	0.7	0.9	0.9	0.7	1.0
Medication: Atorvastatin	0.3	0.4	1.2	0.6	0.5	0.1	0.0	1.0	0.6	-0.0	1.1	0.7	0.7
Illnesses of father: High blood pressure	0.5	0.6	2.8	-0.8	0.1	-0.9	1.7	-0.3	-0.8	-0.3	-0.5	-0.3	-0.7
Alcohol drinker status: Never	2.1	2.5	4.2	-1.9	-2.0	-1.2	-0.3	-1.5	-2.1	-1.8	-1.4	-1.3	-1.6
Ever smoked	0.1	0.2	0.9	0.4	0.4	0.4	0.3	0.1	0.0	0.4	0.1	0.9	0.2
Basal metabolic rate	2.4	13.4	22.1	-4.0	-4.3	-2.7	1.0	-4.7	-3.8	-2.1	-4.0	-3.9	-4.3
Leg fat percentage (left)	4.3	15.6	23.4	-4.8	-4.3	-2.8	1.4	-4.5	-4.5	-2.9	-4.4	-3.7	-4.8
Arm fat-free mass (left)	2.8	14.1	24.6	-4.0	-4.5	-2.7	1.0	-5.0	-4.0	-2.2	-4.2	-3.8	-4.4
Number of operations (self-reported)	0.2	0.3	1.1	0.1	-0.6	1.1	-0.8	-0.0	-0.1	-0.7	-0.1	-0.5	0.1
Average weekly beer plus cider intake	0.4	0.6	1.8	0.8	1.0	0.5	-0.3	0.7	0.5	0.9	0.3	1.3	0.6
Irritability	0.2	0.4	0.7	-0.4	-0.7	0.8	-0.1	-0.6	-0.6	-0.8	-0.7	-0.7	-0.4
Risk taking	1.8	2.6	6.1	1.7	1.5	2.0	-2.5	1.2	1.8	0.2	1.0	1.1	1.9
Ever had prostate specific antigen (PSA) test	1.6	1.8	3.6	-1.7	-1.9	-0.2	-0.3	-1.2	-1.0	-1.4	-1.8	-1.3	-1.6
Fractured/broken bones in last 5 years	0.2	0.2	1.4	-0.0	-0.0	-1.2	0.2	-0.1	0.1	0.3	-0.1	0.6	0.2
Age started oral contraceptive pill	1.1	1.3	3.1	-1.0	-1.2	0.1	-1.7	-1.0	-0.7	-1.6	-1.1	-1.3	-0.9
Diastolic blood pressure, automated reading	1.4	4.2	6.1	-2.4	-2.0	-1.3	1.3	-2.2	-2.3	-1.4	-2.3	-2.4	-2.5
Ever depressed for a whole week	1.0	1.3	2.9	-1.2	-1.0	0.7	0.5	-1.3	-1.1	-0.9	-1.2	-1.7	-1.2
Unable to work because of sickness or disability	0.4	0.5	1.1	-0.5	-0.6	-1.0	0.4	-0.9	-0.5	1.0	-0.9	0.1	-0.7
Commuting to job workplace: Cycle	1.4	1.7	5.3	-1.4	-0.9	1.4	-1.0	0.1	-0.1	-2.3	-1.1	-2.1	-0.5
Myopia	2.9	4.2	7.7	2.0	2.3	1.6	-2.8	1.8	2.3	1.4	2.1	1.6	2.2
Vascular/heart problems diagnosed by doctor	0.5	1.4	8.3	0.9	0.3	2.9	-1.7	0.7	0.8	-0.4	0.5	-0.4	0.7
Cholesterol lowering medication	0.3	0.4	1.1	0.1	0.8	-0.2	0.6	0.5	0.6	0.7	0.7	1.0	0.4
Medication: Omeprazole (e.g. Zanprol)	2.3	2.8	4.6	-2.1	-1.7	-1.0	-0.7	-1.9	-1.7	-1.3	-1.8	-1.9	-1.9
Pain experienced in last month	2.3	3.9	14.8	1.5	1.4	3.9	-2.2	2.1	2.4	-0.4	0.8	0.1	1.9
Supplements: Calcium	1.4	1.5	2.6	1.6	1.5	0.4	-1.3	1.0	1.2	1.1	1.5	0.9	1.4
Basal cell carcinoma (self-reported)	0.4	0.5	1.6	-0.2	-0.8	-0.7	0.5	-0.9	-1.3	-0.3	-0.7	-0.3	-0.8
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.6	-0.8	-0.8	-0.5	0.7	-0.7	-0.5	-0.2	-0.6	-0.3	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.1	-1.1	-0.7	0.3	0.0	-1.0	-0.8	-0.9	-0.7	-0.9	-0.7
Heart disease (siblings)	0.5	0.6	1.9	0.5	0.4	-0.4	1.4	1.1	0.7	1.0	0.6	0.2	0.6
Alcohol drinker status: Previous	0.5	0.6	1.3	-0.7	-0.8	-0.2	0.2	-0.9	-0.9	-1.1	-0.3	-1.1	-0.7
Pack years of smoking	0.6	0.8	3.0	0.3	0.6	1.7	-0.2	1.3	1.3	-0.8	0.3	-0.2	0.9
Impedance of whole body	1.0	5.1	7.0	2.2	2.6	1.5	-1.8	2.6	2.6	1.3	2.6	2.5	2.5
Leg fat mass (left)	4.8	18.7	27.1	-5.2	-4.8	-3.1	1.5	-5.1	-4.8	-3.0	-4.7	-4.2	-5.2
Arm predicted mass (left)	2.6	13.2	23.4	-3.8	-4.3	-2.8	0.9	-4.8	-3.9	-2.0	-4.0	-3.7	-4.3