Best TWAS P=1.45e-12 · Best GWAS P=4.4e-16 conditioned to 0.000676
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Cells Transformed fibroblasts | CD14 | 0.09 | 0.05 | lasso | 4 | 0.06 | 2.7e-05 | -4.5 | -5.4 | 6.2e-08 | -0.05 | 0.13 | 0.84 | FALSE |
2 | GTEx | Esophagus Gastroesophageal Junction | DNAJC18 | 0.17 | 0.01 | lasso | 10 | 0.04 | 2.0e-02 | 3.1 | 6.9 | 7.0e-12 | 0.77 | 0.04 | 0.79 | FALSE |
3 | GTEx | Nerve Tibial | HARS | 0.07 | 0.01 | enet | 16 | 0.04 | 1.1e-03 | -4.2 | 5.2 | 2.4e-07 | -0.03 | 0.57 | 0.07 | FALSE |
4 | GTEx | Skin Sun Exposed Lower leg | WDR55 | 0.04 | 0.01 | enet | 10 | 0.01 | 2.8e-02 | -4.5 | -5.2 | 2.6e-07 | -0.02 | 0.43 | 0.11 | FALSE |
5 | GTEx | Testis | CD14 | 0.13 | 0.10 | lasso | 7 | 0.13 | 3.2e-06 | -4.5 | -5.2 | 2.5e-07 | -0.09 | 0.67 | 0.14 | FALSE |
6 | GTEx | Vagina | PURA | 0.52 | 0.05 | enet | 51 | 0.09 | 3.6e-03 | 5.8 | -7.1 | 1.5e-12 | -0.44 | 0.04 | 0.32 | TRUE |
7 | YFS | Blood | CXXC5 | 0.01 | 0.00 | bslmm | 244 | 0.01 | 2.6e-03 | 8.1 | -6.8 | 1.3e-11 | -0.67 | 0.01 | 0.93 | FALSE |
8 | YFS | Blood | TMCO6 | 0.01 | 0.00 | blup | 329 | 0.01 | 4.1e-03 | -4.6 | -5.5 | 2.9e-08 | -0.03 | 0.74 | 0.10 | FALSE |
9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CD14 | 0.01 | 0.01 | blup | 38 | 0.00 | 3.5e-02 | 4.8 | -5.5 | 3.3e-08 | -0.07 | 0.01 | 0.38 | FALSE |
10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | WDR55 | 0.10 | 0.03 | enet | 8 | 0.04 | 3.3e-09 | -4.7 | -5.5 | 4.0e-08 | 0.01 | 0.02 | 0.95 | FALSE |
11 | The Cancer Genome Atlas | Colon Adenocarcinoma | DND1 | 0.04 | 0.02 | blup | 47 | 0.04 | 3.4e-03 | -3.2 | -5.2 | 2.4e-07 | -0.06 | 0.02 | 0.45 | FALSE |
12 | The Cancer Genome Atlas | Colon Adenocarcinoma | WDR55 | 0.09 | 0.08 | enet | 12 | 0.12 | 1.5e-07 | -4.7 | -6.0 | 2.6e-09 | -0.05 | 0.03 | 0.93 | TRUE |
13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | UBE2D2 | 0.05 | 0.02 | enet | 6 | 0.03 | 4.4e-04 | 4.0 | 6.5 | 8.3e-11 | 0.76 | 0.02 | 0.94 | TRUE |
14 | The Cancer Genome Atlas | Lung Adenocarcinoma | CD14 | 0.03 | 0.01 | blup | 38 | 0.02 | 1.6e-03 | -4.7 | -5.4 | 5.3e-08 | -0.08 | 0.01 | 0.59 | FALSE |
15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | WDR55 | 0.07 | 0.06 | blup | 44 | 0.06 | 1.7e-06 | -4.7 | -5.4 | 6.4e-08 | -0.05 | 0.03 | 0.95 | FALSE |
16 | The Cancer Genome Atlas | Rectum Adenocarcinoma | WDR55 | 0.78 | 0.10 | enet | 17 | 0.17 | 7.1e-05 | 4.5 | -5.3 | 1.1e-07 | -0.01 | 0.01 | 0.28 | FALSE |
17 | The Cancer Genome Atlas | Thyroid Carcinoma | SLC4A9 | 0.07 | 0.02 | blup | 30 | 0.06 | 3.1e-06 | 3.9 | -5.2 | 2.7e-07 | -0.03 | 0.19 | 0.59 | FALSE |