Hub : Genes

HARS

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.1120	0.0560	0.00065	0.169	NA	0.125	NA	0.109	0.00001	NA	0.00016	NA	0.0004
2	GTEx	Brain Hypothalamus	0.1400	0.0760	0.00590	-0.011	NA	-0.010	NA	-0.013	0.68000	NA	0.63000	NA	1.0000
3	GTEx	Nerve Tibial	0.0711	0.0406	0.00170	0.011	NA	0.038	NA	0.018	0.05500	NA	0.00110	NA	0.0190
4	GTEx	Thyroid	0.0490	0.0290	0.00970	-0.002	NA	-0.004	NA	-0.002	0.55000	NA	0.90000	NA	0.5800
5	ROSMAP	Brain Pre-frontal Cortex	0.0247	0.0189	0.01700	0.001	0.002	0.009	0.005	0.004	0.24000	0.150	0.02100	0.058	0.0990
6	TCGA	Pancreatic Adenocarcinoma	0.3510	0.1630	0.00730	0.014	0.030	0.010	NA	0.003	0.07800	0.020	0.12000	NA	0.2300
7	TCGA	Soft Tissue Sarcoma	0.0440	0.0320	0.00780	0.054	0.020	0.035	NA	0.035	0.00038	0.023	0.00380	NA	0.0037

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	1.3	2.1	3.7	-1.9	-1.3	-1.5	-1.0	-1.1	-1.4	1.6
Bipolar Disorder or Schizophrenia	6.6	16.0	25.0	-5.0	-4.5	-4.1	-3.1	-4.1	-2.1	4.4
Depressed Affect (Nagel 2018)	3.2	6.8	12.3	3.5	1.7	3.5	3.5	1.8	1.7	-1.4
Depression (Nagel 2018)	6.4	9.7	16.3	4.0	2.0	3.4	1.6	4.0	3.0	-2.9
Intelligence (Savage-Jansen 2018)	8.3	25.5	41.0	6.4	4.5	6.0	3.9	5.6	3.6	-4.6
Neuroticism (Nagel 2018)	2.0	4.7	9.0	2.8	-0.0	3.0	2.2	2.6	1.8	-1.2
Schizophrenia (2018)	7.7	16.1	23.6	-4.9	-4.8	-4.0	-3.2	-4.4	-1.4	4.3
Schizophrenia vs Biploar Disorder	0.5	0.7	1.8	-0.9	0.7	-0.4	-0.4	-0.2	-1.3	-1.1
Worry (Nagel 2018)	0.3	0.6	1.2	0.2	-1.1	0.4	1.0	0.8	1.1	0.4
Alzheimer’s Disease (in mother)	1.1	1.3	3.2	-1.5	-0.5	-1.6	-0.6	-0.8	0.2	1.8
Alzheimer’s Disease (in father)	0.3	0.4	0.9	-0.6	0.2	-0.6	0.9	-0.7	-0.5	-0.1
Alzheimer’s Disease (including proxy)	2.7	3.9	9.1	-3.0	-1.2	-2.6	-0.9	-1.9	-0.2	2.4
Crohns Disease (2017)	1.5	3.3	7.7	2.1	2.6	1.5	0.8	1.2	0.2	-2.8
Irritable Bowel Disease (IBD)	1.0	2.3	5.2	1.4	1.8	1.4	1.7	1.0	-0.4	-2.3
Ulcerative Colitis (UC)	0.6	1.1	4.4	0.2	0.8	0.6	2.1	0.6	-0.8	-1.2
Major Depression (MDD)	2.0	2.4	4.7	1.5	1.2	1.8	0.6	2.1	0.4	-2.2
Reaction Time	0.2	0.5	1.0	0.5	0.0	0.6	-0.9	0.9	0.2	-1.0
Verbal and Numeric Reasoning (VNR)	5.0	12.0	22.2	4.3	2.5	4.7	3.4	3.6	2.4	-2.6
Breast Cancer	0.1	0.2	0.6	0.8	0.5	0.7	0.0	0.0	0.5	0.3
Ovarian Cancer	0.5	0.6	2.7	0.7	0.1	1.6	-1.0	0.0	0.2	-0.4
Prostate Cancer	0.6	0.8	2.0	0.1	-1.3	0.9	-1.4	-0.8	0.7	0.3
Age at First Birth	0.4	0.5	2.3	-0.0	-0.3	0.0	0.5	-0.4	1.5	0.9
Bipolar Disorder (2011)	2.8	2.7	4.6	-2.1	-1.7	-1.3	-1.7	-1.4	-1.9	1.3
Body Mass Index (BMI) (2010)	0.4	0.6	1.9	0.9	0.3	1.4	0.6	0.4	-0.6	-0.5
Coronary Artery Disease (CAD)	0.8	1.0	2.2	1.0	-0.1	1.4	-0.6	1.0	-0.1	-1.5
Crohns Disease (2012)	0.4	0.6	1.1	0.8	0.8	1.0	0.9	0.2	-0.1	-1.1
Mean Putamen Volume	1.5	1.7	3.2	1.2	0.7	1.7	-0.4	1.5	1.2	-1.8
Fasting Glucose	0.8	1.0	1.9	-1.2	-0.6	-0.3	-0.7	-1.4	-1.1	1.2
HbA1C	1.1	1.2	4.5	0.5	1.7	0.1	2.1	0.5	-0.8	-0.1
HDL Cholesterol	0.1	0.2	1.0	-0.3	-0.0	-0.3	1.0	-0.2	-0.1	0.5
LDL Cholesterol	0.2	0.4	1.2	-1.1	-0.6	-0.3	-0.2	0.8	0.5	-0.5
Lupus	0.3	0.5	1.0	0.9	0.5	0.5	0.4	0.8	1.0	-0.7
Neuroticism (2016)	1.7	2.5	11.6	1.6	1.0	1.1	0.7	0.8	3.4	-0.2
Primary Biliary Cirrhosis	1.8	2.6	6.4	1.5	2.5	0.9	0.8	1.2	-0.3	-2.5
Rheumatoid Arthritis	0.6	0.9	3.7	-0.6	-0.7	0.1	-1.1	-0.6	-1.9	-0.1
Schizophrenia (2014)	4.1	9.1	15.1	-3.6	-3.4	-2.7	-2.3	-3.1	-1.3	3.9
Triglycerides	0.6	1.0	2.7	-0.5	-1.6	0.0	-1.1	0.6	1.5	0.5
Type 2 Diabetes (T2D) (2012)	1.3	1.5	5.5	0.5	1.4	0.5	2.4	1.2	0.4	-0.6
Ulcerative Colitis	0.6	0.9	3.3	-0.5	0.5	0.2	1.4	0.5	-1.8	-0.6
Blood Eosinophil Count	0.1	0.8	2.0	1.0	-0.3	0.7	-1.1	1.4	0.7	-0.7
Blood Platelet Count	0.5	5.6	8.9	-2.5	-2.7	-2.2	-2.6	-1.4	1.6	3.0
Blood Red Count	0.2	2.3	7.6	-1.1	-1.5	-1.4	-0.8	-0.8	-2.8	1.4
Blood White Count	0.7	5.0	12.0	-2.2	-2.2	-2.0	-3.0	0.3	-3.5	-0.1
Heel T-Score	0.4	2.9	11.0	-1.7	-0.7	-1.3	1.8	-0.2	-3.3	0.9
BMI	1.6	9.5	22.2	4.3	1.9	4.7	1.0	3.3	1.4	-2.9
Height	0.7	13.6	32.9	5.2	3.9	5.7	1.9	1.2	-2.5	-3.0
Waist Hip Ratio (WHR)	0.8	3.7	9.0	-3.0	-1.3	-3.0	-0.6	-2.1	-0.3	1.3
Systolic Blood Pressure	4.8	24.1	53.2	-7.3	-5.4	-5.7	-4.0	-2.7	-4.2	3.6
Smoking Status	0.6	1.4	4.1	1.4	0.3	2.0	0.1	1.5	0.6	-0.9
Allergy or Eczema	1.6	4.2	7.8	2.5	2.0	2.8	1.8	1.5	0.7	-2.3
Cardiovascular Disease	0.2	0.5	2.8	-0.7	0.1	0.2	1.7	0.6	-0.2	0.1
Hypothyroidism (self reported)	0.2	0.5	0.8	-0.9	-0.6	-0.7	-0.5	0.8	-0.2	-0.7
Respiratory disease	6.1	13.5	22.5	4.4	2.8	4.6	2.4	4.7	1.0	-4.0
Type 2 Diabetes (T2D) (2018)	0.3	0.6	2.9	-0.5	0.3	0.0	-1.7	0.7	0.8	-0.2
Lung FEV1/FVC ratio	0.3	1.4	4.3	0.8	1.5	1.4	0.1	0.4	-0.4	-2.1
Lung FVC	2.9	14.7	19.1	4.4	3.6	4.1	2.8	4.2	3.5	-4.0
Neuroticism	2.6	6.3	10.1	3.2	0.9	3.1	2.9	2.5	2.5	-1.6
Chronotype (morning person)	1.0	2.4	5.2	1.0	2.3	1.1	1.6	1.4	-0.8	-2.1
Hair Pigment	0.1	1.9	3.6	-1.4	-1.9	-1.7	-1.3	-1.1	0.3	1.3
Tanning	0.1	1.6	4.1	-1.0	0.7	-0.3	0.5	-2.0	-2.0	1.2
Hand grip strength (left)	0.3	0.7	3.5	-0.2	0.6	0.5	-0.1	-0.2	-1.9	-0.7
Number of treatments/medications taken	0.1	0.2	0.5	-0.7	-0.5	-0.2	0.4	0.1	-0.3	0.5
Average weekly spirits intake	1.1	1.4	5.1	0.4	0.9	0.2	-0.7	2.3	0.7	-1.6
Sensitivity / hurt feelings	0.3	0.4	0.7	0.8	-0.6	0.6	0.8	0.6	0.7	0.4
Frequency of depressed mood in last 2 weeks	3.7	5.2	7.8	2.7	1.3	2.4	2.8	2.3	2.3	-1.9
Hearing difficulty/problems: Yes	0.1	0.2	0.5	0.7	-0.2	0.4	-0.1	0.3	0.7	0.1
Relative age of first facial hair	0.8	1.6	3.9	1.4	1.0	0.9	1.2	1.3	0.5	-2.0
Other serious medical condition/disability diagnosed by doctor	1.8	2.3	2.8	1.6	1.6	1.6	1.1	1.3	1.7	-1.6
Ever used hormone-replacement therapy (HRT)	2.6	3.3	8.0	1.5	2.1	1.5	2.8	1.6	-0.2	-1.7
Ever had hysterectomy (womb removed)	1.0	1.2	2.5	1.5	1.6	0.9	0.2	0.6	-0.1	-1.5
Systolic blood pressure, automated reading	1.8	5.2	9.9	-3.1	-3.1	-2.2	-2.5	-0.6	-2.1	1.3
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	1.6	1.1	0.9	1.2	-0.3	1.3	-0.9	-1.2
Angina	0.0	0.1	0.1	-0.2	0.3	0.1	-0.3	0.3	0.2	-0.3
Medication for hormone replacement therapy	0.8	0.9	1.9	0.2	1.4	-0.7	1.2	0.6	-1.0	-1.0
Vitamin and mineral supplements	0.6	0.8	2.6	-0.2	0.1	0.6	-0.2	0.4	-1.6	-1.5
Supplements: Zinc	1.7	1.8	4.7	0.6	1.6	-0.2	2.2	0.7	1.3	-1.6
Medication: Co-codamol	0.1	0.1	0.4	-0.2	-0.1	-0.3	0.2	0.2	-0.4	-0.7
Medication: Metformin	0.2	0.3	0.8	-0.2	-0.9	0.7	-0.7	-0.2	-0.1	0.1
Diabetes (father)	0.4	0.5	1.4	-0.6	-0.0	-0.7	-1.2	-0.2	-0.3	0.8
Diabetes (mother)	0.6	0.8	2.3	0.7	0.5	0.1	-0.5	0.9	1.1	-1.5
Severe depression (siblings)	0.4	0.5	1.2	-1.1	-0.7	-0.5	-0.8	-0.3	-0.5	0.7
Pack years adult smoking proportion	0.4	0.6	2.7	-0.1	-0.1	0.0	-1.6	0.7	-1.0	-0.2
Impedance of leg (right)	0.8	4.0	13.1	-2.3	-0.4	-2.6	-0.4	-1.4	-3.6	-0.9
Leg fat-free mass (left)	2.1	11.3	30.9	4.9	3.1	5.6	1.4	2.7	0.8	-2.3
Trunk fat percentage	1.2	5.0	9.1	2.8	2.1	2.8	-0.6	1.7	-1.3	-3.0
Hand grip strength (right)	0.1	0.4	1.8	0.2	0.7	0.1	-0.2	0.2	-1.3	-0.4
Townsend deprivation index at recruitment	1.5	2.2	11.1	0.1	0.5	-0.7	-1.8	0.5	3.3	-0.3
Current tobacco smoking	0.7	1.1	3.5	0.9	-0.0	1.1	-0.6	1.9	0.1	-1.4
Average weekly fortified wine intake	0.3	0.3	1.2	0.3	0.8	0.4	1.1	-0.0	-0.2	-0.1
Maternal smoking around birth	0.6	0.8	2.6	-1.1	-0.9	-1.1	-1.6	-0.1	-0.2	0.3
Fed-up feelings	1.6	2.9	7.1	2.1	0.5	1.9	2.7	0.6	2.0	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	3.1	4.1	7.6	2.2	1.7	1.8	0.7	2.8	2.2	-2.2
Relative age voice broke	0.2	0.4	0.9	-0.2	-0.6	-0.4	0.9	-0.6	0.1	0.9
Taking other prescription medications	1.0	1.6	4.7	1.1	1.1	1.4	0.9	2.2	0.1	-1.1
Age when periods started (menarche)	1.9	4.5	10.0	-2.8	-2.3	-3.2	-1.5	-0.8	1.5	1.9
Bilateral oophorectomy (both ovaries removed)	3.0	3.5	7.4	2.2	2.1	2.2	-0.1	1.7	-0.4	-2.7
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	4.4	-0.3	0.3	0.4	1.1	1.6	-2.1	-1.0
Tinnitus: Yes, but not now, but have in the past	2.7	2.8	4.5	1.6	1.9	1.7	2.1	1.0	-1.0	-2.0
Qualifications: CSEs or equivalent	0.3	0.4	1.0	1.0	0.5	0.4	0.5	-0.3	-0.9	-0.3
Serious illness, injury or assault to yourself	0.4	0.5	1.4	-1.2	-1.1	-0.2	0.5	-0.2	-0.2	-0.6
High blood pressure	0.2	0.5	2.0	-1.4	-0.7	0.0	0.0	1.0	-0.2	0.4
Hayfever, allergic rhinitis or eczema	1.0	2.1	3.6	1.7	1.8	1.2	1.9	0.9	0.1	-1.6
Multivitamins +/- minerals	0.3	0.4	1.2	0.2	0.2	-0.2	-0.5	-1.1	0.6	1.0
Stomach or abdominal pain in last month	1.2	1.4	2.8	-1.2	-1.4	-1.0	-1.7	-0.5	1.2	1.1
Supplements: Glucosamine	3.2	4.1	12.0	-2.1	-2.2	-1.5	-0.1	-2.2	0.7	3.5
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	3.9	1.8	1.1	1.6	0.6	1.2	-0.9	-2.0
Medication: Atenolol	0.8	1.0	2.4	-1.4	-0.7	-0.6	-0.7	-0.8	-1.6	0.6
Medication: Levothyroxine sodium	0.2	0.4	1.1	-1.0	-0.2	-0.3	-0.7	0.9	-0.4	-0.3
Sitting height	2.4	16.8	35.6	6.0	4.8	5.9	2.8	2.8	-0.1	-3.1
Chronic bronchitis/emphysema (father)	0.3	0.3	1.1	-0.2	-0.0	-1.0	0.8	0.6	0.1	-0.3
High blood pressure (mother)	0.5	0.8	2.1	0.3	1.2	-0.0	-0.2	1.2	-0.6	-1.5
Body mass index (BMI)	0.9	4.0	11.7	2.7	1.3	3.4	-0.2	1.7	0.2	-2.1
Impedance of leg (left)	0.9	4.3	13.8	-2.3	-0.0	-2.7	-1.0	-1.3	-3.7	-0.9
Leg predicted mass (left)	2.2	11.5	30.8	4.8	3.2	5.5	1.5	2.8	0.8	-2.4
Trunk fat mass	1.7	7.3	15.5	3.6	2.7	3.9	0.1	2.0	-1.2	-3.2
Waist circumference	1.2	4.2	11.0	2.7	2.0	3.3	0.2	1.2	-0.1	-2.5
Number of incorrect matches in round	0.6	1.1	2.0	-1.2	-0.7	-1.4	0.9	-1.2	-0.9	0.8
Past tobacco smoking	1.0	1.8	5.0	-2.0	-0.6	-2.2	0.1	-0.8	-1.2	1.0
Alcohol usually taken with meals	0.8	1.4	3.9	0.5	0.8	0.6	1.7	-0.3	-2.0	-1.2
Nervous feelings	0.2	0.4	0.7	-0.5	-0.7	-0.3	0.8	0.8	0.8	0.1
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.3	5.8	1.6	-0.1	2.4	0.6	1.0	2.0	-1.5
Hearing difficulty/problems with background noise	1.0	1.6	3.3	1.6	1.4	1.8	1.0	0.5	1.4	-0.3
Hair/balding pattern: Pattern 2	0.5	0.6	2.4	0.4	1.0	1.5	-0.1	0.5	-0.5	-0.6
Had menopause	0.4	0.4	2.4	0.3	-0.7	0.3	1.6	0.1	-0.2	0.1
Had other major operations	1.9	2.4	5.3	2.3	1.6	2.2	0.7	0.7	1.1	-1.3
Forced vital capacity (FVC)	4.9	18.9	27.6	4.9	5.1	5.3	3.7	3.8	0.7	-5.0
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.6	1.6	-0.7	-0.1	-0.1	0.8	1.0	-1.3	-0.5
Ever unenthusiastic/disinterested for a whole week	8.4	10.3	19.8	4.5	3.5	3.8	2.0	2.7	2.2	-3.2
Qualifications: None of the above	2.1	4.4	10.5	-2.7	-1.4	-2.9	-1.0	-1.4	-3.2	0.1
Financial difficulties in last 2 years	1.7	2.2	5.8	2.0	-0.5	2.2	0.3	0.2	2.4	-0.5
Mouth/teeth dental problems	1.5	2.3	6.6	1.1	1.6	0.5	-0.1	2.2	0.6	-2.6
Heart attack	1.9	2.4	7.4	-1.6	-2.7	-0.7	-1.0	-1.7	-0.5	1.5
Allergy	1.9	4.3	8.5	-2.9	-2.0	-2.5	-1.9	-1.7	-0.4	2.2
Pain all over the body in last month	0.1	0.1	0.3	0.3	-0.0	0.3	0.2	0.6	0.0	-0.3
Diabetes (self-reported)	0.2	0.3	1.0	-0.4	-0.2	0.7	-1.0	-0.2	-0.2	0.2
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.8	0.6	-0.8	0.9	0.5	0.4	0.6	-0.5
Medication: Ramipril	1.6	2.0	3.7	-1.9	-1.6	-1.0	-1.0	-1.3	-1.7	1.3
Medication: Simvastatin	3.4	5.0	7.7	-2.8	-2.2	-2.3	-2.4	-2.3	1.1	2.1
Fluid intelligence score	2.7	5.6	10.7	2.9	2.3	3.3	2.4	1.9	1.8	-1.6
Illnesses of siblings	0.2	0.3	1.9	-0.2	0.1	-0.1	1.4	-0.1	-0.2	0.1
Neuroticism score	1.6	3.3	5.3	2.0	-0.2	2.1	2.3	1.9	2.3	-1.0
Weight	2.3	11.1	27.5	4.6	3.3	5.2	1.1	2.6	-0.5	-3.2
Impedance of arm (right)	0.7	3.4	12.7	-2.2	-0.6	-3.6	-0.6	-1.4	-1.9	0.0
Arm fat percentage (right)	0.6	2.4	5.4	1.9	1.0	2.1	-0.9	1.3	-0.3	-2.3
Trunk fat-free mass	2.1	12.3	34.1	4.8	3.5	5.8	2.2	2.5	0.3	-2.5
Hip circumference	2.7	11.5	26.7	4.6	3.4	5.2	1.4	2.5	-1.0	-3.5
Time employed in main current job	2.3	2.7	5.0	1.8	1.8	1.6	2.2	1.3	-0.4	-1.7
Alcohol intake versus 10 years previously	1.8	2.7	6.8	-1.1	-1.7	-0.8	-1.3	-1.3	2.6	2.1
Father’s age at death	0.6	0.8	2.3	-0.1	0.3	0.2	1.5	-1.5	0.8	0.5
Worrier / anxious feelings	0.7	1.3	2.6	-0.6	-1.6	-1.2	0.6	0.7	1.4	1.3
Frequency of tiredness / lethargy in last 2 weeks	4.4	7.2	15.8	2.8	2.6	4.0	0.9	2.8	1.3	-3.1
Falls in the last year	1.7	2.3	9.2	0.9	0.7	1.7	-0.3	1.5	3.0	-0.8
Hair/balding pattern: Pattern 3	0.8	1.2	5.3	0.1	-0.9	-0.7	0.2	1.0	2.3	0.9
Number of live births	1.1	1.6	3.7	-1.4	-1.0	-1.1	-1.9	-1.3	0.7	0.9
Forced expiratory volume in 1-second (FEV1)	4.4	14.9	25.5	4.1	4.9	4.5	2.8	3.2	0.4	-5.1
Pulse rate	0.8	1.3	3.7	-0.0	-1.2	-1.0	-1.0	0.2	1.9	1.4
Happiness	3.5	4.3	12.7	2.3	0.7	2.7	1.1	1.4	3.6	-1.1
Noisy workplace	0.6	0.7	1.8	0.6	1.3	0.8	-0.4	0.9	0.2	-1.1
Qualifications: A levels/AS levels or equivalent	0.9	2.0	4.0	1.5	1.2	1.8	2.0	1.5	0.2	-0.9
Serious illness, injury or assault of a close relative in last 2 years	2.9	3.3	4.9	2.2	1.6	2.1	2.1	1.9	-0.6	-1.8
Mouth/teeth dental problems: Dentures	0.2	0.3	1.0	0.6	0.7	-0.0	1.0	-0.5	0.0	-0.3
Asthma	4.7	9.2	16.4	3.4	2.1	3.7	1.9	4.0	0.6	-3.8
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	5.9	1.0	0.8	1.5	2.4	0.8	0.7	-0.0
Medication: Cholesterol lowering	1.1	1.7	2.7	-0.9	-1.5	-0.8	-1.4	-1.2	1.6	1.5
Depression (self-reported)	0.5	0.6	1.8	-0.5	-0.5	0.2	-1.1	0.4	-1.4	-0.7
Medication: Lansoprazole	0.6	0.7	1.7	0.5	1.0	1.3	-0.5	0.2	1.3	0.3
Prospective memory result	0.4	0.5	1.7	-1.1	-1.3	-0.4	-0.5	0.7	-0.1	-0.2
Lung cancer (father)	0.7	0.8	1.5	-1.1	-1.0	-0.4	0.6	-0.9	-0.8	1.2
Illnesses of mother	0.8	1.0	3.3	1.2	0.4	1.8	0.4	1.2	0.5	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	5.8	18.4	27.6	4.7	5.2	5.2	3.3	3.5	1.7	-5.0
Pulse wave Arterial Stiffness index	0.6	0.8	2.5	0.4	-0.5	0.3	-1.2	1.6	0.5	-0.8
Impedance of arm (left)	0.5	2.2	8.3	-1.6	-0.1	-2.9	-0.8	-1.1	-1.5	-0.2
Arm fat mass (right)	1.5	6.2	14.2	3.3	2.1	3.8	0.2	2.2	-0.4	-2.9
Trunk predicted mass	2.1	11.8	32.5	4.7	3.5	5.7	2.1	2.4	0.4	-2.4
Standing height	1.3	12.7	22.1	4.6	4.6	4.7	2.8	2.1	-1.8	-3.0
Length of working week for main job	2.3	2.5	5.4	2.3	0.9	1.8	1.4	2.2	0.4	-1.1
Exposure to tobacco smoke at home	0.4	0.5	1.1	0.4	-0.6	0.7	-0.1	-0.8	1.0	0.8
Breastfed as a baby	0.7	0.8	3.7	-0.1	-0.2	-0.3	-1.9	0.9	0.8	0.6
Tense / ‘highly strung’	0.5	0.8	2.5	1.0	-0.1	0.9	-0.5	1.0	1.6	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.1	3.8	1.9	1.5	1.3	1.1	1.3	1.5	-1.1
Hair/balding pattern: Pattern 4	2.4	5.8	14.7	-2.0	-2.4	-1.6	-2.0	-3.8	-1.7	2.6
Birth weight of first child	0.2	0.3	1.3	0.0	0.6	0.0	-1.1	-0.8	0.3	0.1
Peak expiratory flow (PEF)	0.3	0.6	2.0	-0.1	1.4	0.6	-0.3	-0.9	-0.5	-0.8
Pulse wave reflection index	0.9	1.1	4.5	0.7	0.9	0.6	0.3	1.2	-0.4	-2.1
Ever highly irritable/argumentative for 2 days	1.4	1.6	5.1	1.8	0.6	2.2	1.0	0.9	0.8	-0.5
Loud music exposure frequency	1.3	1.5	2.5	1.3	1.6	0.7	0.0	1.5	-1.1	-1.4
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.8	0.1	-0.3	0.9	-0.5	-0.6	-0.3	0.2
Mouth/teeth dental problems: Bleeding gums	3.5	4.6	9.7	-2.4	-2.6	-1.5	-0.7	-2.7	-0.5	3.1
Blood clot in the leg (DVT)	0.7	0.9	2.6	1.2	1.0	1.6	-0.1	-0.6	0.9	-0.5
Medication: Paracetamol	0.7	1.2	3.3	-0.9	-0.9	-0.6	-0.5	-1.4	-0.9	1.8
Headache pain in last month	1.0	1.8	5.3	-1.1	-0.9	-2.0	-1.0	0.1	-2.3	0.2
Medication for cholesterol, blood pressure or diabetes	2.0	3.3	5.6	2.0	1.9	1.6	1.6	2.1	-0.6	-2.4
Glaucoma (self-reported)	0.4	0.4	0.9	0.5	0.9	0.7	0.7	0.6	-0.5	-0.5
Gout (self-reported)	2.2	3.0	4.8	1.6	2.2	1.3	2.0	2.1	0.7	-1.8
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.2	-0.4	0.3	0.0	0.1	0.9	-1.1	-0.7
Medication: Amlodipine	1.9	2.7	5.9	-2.4	-1.4	-1.6	-0.1	-2.3	-0.5	1.8
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.1	-0.9	-1.5	-0.5	-1.5	-0.1	0.6	0.6
Birth weight	1.1	2.4	6.9	2.6	1.5	2.6	-0.1	-0.3	0.5	-0.8
Chronic bronchitis/emphysema (mother)	0.3	0.3	1.7	0.2	0.0	0.3	-0.4	-0.4	1.3	-0.6
High blood pressure (siblings)	0.4	0.6	1.4	0.5	0.8	0.0	-1.0	1.2	-0.4	-0.7
Forced vital capacity (FVC), Best measure	5.2	19.0	29.1	5.0	5.1	5.4	3.9	3.6	1.5	-4.8
Body fat percentage	1.0	3.9	8.1	2.4	1.8	2.5	-0.7	1.4	-1.3	-2.8
Leg fat percentage (right)	1.0	3.6	8.2	1.7	1.3	2.5	-0.2	0.9	-2.2	-2.9
Arm fat-free mass (right)	2.6	13.4	35.9	5.0	3.8	6.0	2.0	2.8	0.4	-2.6
Exposure to tobacco smoke outside home	0.6	0.8	2.5	-0.3	-0.3	-0.5	-1.1	-0.5	1.6	1.1
Comparative body size at age 10	0.5	1.5	2.1	1.4	1.5	1.4	1.4	1.0	-0.7	-1.1
Number of full brothers	0.8	1.0	2.6	1.6	0.6	1.0	-0.4	1.0	1.2	-0.9
Worry too long after embarrassment	1.2	2.0	6.0	1.3	-0.2	1.4	0.3	2.4	0.9	-1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	4.9	1.7	0.2	1.4	0.2	2.2	-0.4	-1.1
Wheeze or whistling in the chest in last year	1.4	2.5	3.9	1.8	-0.4	2.0	1.4	1.9	1.8	-1.1
Number of children fathered	1.1	1.2	2.3	0.8	0.9	1.2	1.1	0.4	-1.5	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	2.2	-0.0	0.7	0.2	0.7	-0.6	1.5	0.0
Age at first live birth	0.1	0.2	0.9	0.1	0.9	0.3	0.1	-0.2	-0.2	-0.2
Pulse wave peak to peak time	0.7	0.8	2.5	0.0	0.7	0.2	1.6	-1.5	-0.4	0.7
Health satisfaction	0.8	1.0	2.5	1.3	0.3	1.6	1.0	0.8	0.2	-1.0
Shortness of breath walking on level ground	1.8	2.1	4.0	2.0	1.1	1.6	-0.4	1.6	0.9	-1.8
Qualifications: College or University degree	1.3	4.0	7.1	2.4	1.9	2.7	1.4	2.4	0.8	-1.9
Eye problems/disorders: None of the above	4.9	5.6	10.0	-2.7	-3.0	-3.2	-0.8	-1.7	-0.1	3.1
Mouth/teeth dental problems: Loose teeth	3.5	4.2	6.7	-1.2	-2.4	-1.2	-2.6	-2.2	2.0	2.2
Emphysema/chronic bronchitis	1.0	1.1	1.8	1.3	0.5	1.1	-1.0	1.3	1.1	-0.8
Medication for pain relief, constipation, heartburn	0.2	0.3	0.9	-0.4	0.3	-0.9	-0.5	0.1	-0.3	-0.7
Neck or shoulder pain in last month	1.9	2.7	5.8	2.0	1.4	1.2	1.7	1.2	2.4	-1.0
Medication: Blood pressure	2.4	4.3	6.9	-2.6	-2.1	-2.2	-1.8	-2.0	0.1	2.6
Angina (self-reported)	0.0	0.1	0.2	-0.2	0.2	-0.1	-0.2	0.2	0.4	-0.2
Migraine (self-reported)	0.3	0.3	0.9	-0.0	1.0	-0.6	-0.8	0.1	-0.5	-0.3
Medication: Ibuprofen	0.5	0.5	2.0	-0.1	-0.1	0.4	1.4	0.4	0.9	0.7
Medication: Allopurinol	0.5	0.7	3.1	-0.2	0.6	-0.1	1.8	0.7	0.8	-0.4
Medication: Omeprazole	0.4	0.5	2.8	-0.6	-0.2	0.3	-1.7	0.0	0.0	0.3
Medication: Seretide 50 evohaler	2.8	3.2	8.8	3.0	0.6	2.8	1.3	1.6	0.6	-1.0
Mean time to correctly identify matches	0.4	0.8	3.7	-0.2	-1.2	-0.1	-1.9	0.6	0.4	-0.5
Heart disease (mother)	1.3	1.6	5.4	1.7	0.5	2.3	0.8	1.1	0.2	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.2	5.8	-2.1	-1.0	-2.4	0.4	-1.1	0.9	1.4
Whole body fat mass	1.4	5.9	12.6	3.2	2.3	3.5	-0.0	1.8	-1.2	-3.0
Leg fat mass (right)	1.5	5.7	13.0	3.0	2.1	3.6	0.3	1.8	-1.5	-2.9
Arm predicted mass (right)	2.6	13.2	36.4	4.9	3.6	6.0	1.8	2.9	0.2	-2.7
Pulse rate, automated reading	0.8	2.6	7.7	-1.1	-2.1	-1.4	-2.8	-0.1	0.9	1.6
Alcohol intake frequency.	1.0	2.3	5.3	-0.7	-1.4	-1.3	-2.2	-0.3	2.3	1.2
Comparative height size at age 10	0.6	3.4	9.4	2.6	2.2	3.1	1.1	0.6	-0.6	-0.6
Number of full sisters	0.5	0.6	2.0	0.2	0.1	0.3	-1.4	0.9	0.3	-1.0
Suffer from ‘nerves’	0.2	0.4	1.0	-0.2	-1.0	0.5	1.0	0.0	-0.1	0.6
Overall health rating	0.4	0.9	2.9	-1.3	-0.7	-0.6	-1.7	-0.2	-0.7	-0.3
Chest pain or discomfort	2.1	3.1	9.4	1.8	1.4	1.8	0.6	1.3	3.1	-1.3
Had major operations	1.1	1.3	2.7	-0.5	-1.3	0.5	1.6	-1.4	-0.5	1.5
Age at last live birth	0.1	0.2	0.7	0.2	0.6	0.0	-0.9	0.4	0.3	0.0
Family relationship satisfaction	3.2	3.9	10.7	2.4	0.9	2.4	0.6	1.7	3.3	-1.1
Leg pain on walking	1.2	1.5	3.8	1.6	0.8	1.9	0.7	0.4	1.2	-1.1
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	5.0	-0.3	-1.3	-0.8	-2.2	-1.1	1.7	1.4
Commuting to job workplace: Car/motor vehicle	1.1	1.3	4.9	-0.3	0.6	-0.3	-0.7	0.9	-2.2	-1.4
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.6	0.5	1.2	-0.5	-1.2	0.9	-0.0	-0.2
Medication: Aspirin	0.4	0.5	1.0	-0.8	-0.6	-0.3	-0.7	-1.0	-0.1	1.0
Supplements: Vitamin C	1.2	1.4	3.5	-0.6	-0.6	-1.9	1.7	0.5	1.3	0.7
Knee pain experienced in last month	0.7	1.1	3.3	0.8	-0.9	1.5	0.4	0.5	1.8	0.6
Hypertension (Self-reported)	0.3	0.9	3.1	-1.8	-1.2	-0.3	0.4	0.3	-0.7	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	2.0	0.4	0.5	1.4	-0.5	0.3	-0.2	-0.8
Illnesses of father: Heart disease	0.5	0.7	1.9	-0.3	-1.4	-0.5	-1.0	-1.0	0.6	0.7
Illnesses of siblings: Diabetes	0.3	0.4	1.5	0.9	0.1	0.3	0.7	0.3	1.2	0.1
Smoking status: Previous	0.6	0.9	2.6	1.5	0.6	1.6	0.2	0.4	0.9	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.1	6.8	1.5	2.6	1.3	1.0	1.9	-1.1	-2.2
Whole body fat-free mass	2.3	13.0	35.9	5.0	3.5	6.0	1.9	2.7	0.6	-2.5
Leg fat-free mass (right)	2.2	11.6	30.9	4.9	3.3	5.6	1.2	2.7	0.9	-2.3
Arm fat percentage (left)	0.7	2.9	5.9	2.1	1.2	2.4	-0.8	1.3	-0.1	-2.4
Average weekly red wine intake	0.5	0.7	3.4	0.0	-0.4	0.4	1.9	1.0	-0.1	-0.6
Handedness (chirality/laterality): Left-handed	0.9	1.1	2.9	-1.0	-0.0	-1.7	-1.3	-0.2	1.2	0.7
Mood swings	0.6	1.1	3.8	0.9	0.7	1.0	1.9	0.1	1.3	-0.4
Loneliness, isolation	0.8	1.1	4.3	0.8	-0.7	1.1	-0.1	1.0	2.1	-0.1
Long-standing illness, disability or infirmity	1.2	1.8	3.2	1.5	1.6	1.7	-0.1	1.4	0.2	-1.8
Ever had bowel cancer screening	0.6	0.8	2.1	0.2	-0.7	0.0	-0.2	0.8	1.4	1.4
Diabetes diagnosed by doctor	0.3	0.4	2.6	-0.5	0.0	0.4	-1.6	-0.1	-0.2	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	2.5	1.0	1.6	0.8	-0.1	0.7	0.3	-1.0
Friendships satisfaction	8.0	9.9	23.2	3.8	1.9	3.2	1.4	3.2	4.8	-2.4
Qualifications: nursing, teaching	1.4	2.2	4.9	1.7	0.7	2.2	1.2	1.5	-0.3	-1.8
Commuting to job workplace: Walk	2.0	2.1	3.7	-1.6	-1.0	-1.2	-1.5	-1.9	-0.5	1.9
Eye problems/disorders: Cataract	1.6	1.8	4.4	2.1	1.6	2.0	0.9	-0.4	0.1	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.6	0.1	-0.7	1.2	0.2	-0.5	-1.3	0.6
Medication for cholesterol	0.7	1.0	2.8	0.8	-0.2	-0.2	-1.0	-0.3	1.7	1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	4.0	4.7	9.1	2.4	3.0	1.7	1.7	2.3	0.6	-2.6
Back pain experienced in last month	0.5	0.8	2.8	0.6	-0.2	-0.0	0.8	0.7	1.0	-1.7
Mineral and other dietary supplements	1.5	2.0	4.7	1.5	1.4	1.2	1.1	1.1	-1.1	-2.2
Breast cancer (self-reported)	0.4	0.5	1.8	0.0	-0.5	0.5	-1.4	-0.3	-1.1	-0.3
Asthma (self-reported)	5.2	10.4	17.3	3.7	2.3	4.0	2.2	4.2	0.6	-4.0
Osteoporosis (self-reported)	0.8	1.0	3.6	0.7	0.9	-0.4	-0.8	1.9	0.7	-0.9
Osteoarthritis (self-reported)	1.1	1.4	3.7	1.9	0.6	1.7	0.6	0.5	1.4	-0.2
Medication: Aspirin	0.8	1.0	1.8	-1.3	-0.9	-0.9	-0.9	-1.1	0.2	1.3
Medication: Gliclazide	0.4	0.4	1.9	0.1	0.5	0.3	-1.4	0.4	-0.8	0.1
Illnesses of father: None of the above (group 1)	0.7	0.9	1.4	1.1	1.2	1.2	0.5	0.9	0.7	-0.8
Smoking status: Current	0.5	0.7	2.4	0.7	-0.0	0.9	-0.2	1.5	-0.2	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.9	6.1	12.5	2.3	2.4	2.3	1.7	2.6	1.9	-3.5
Whole body water mass	2.3	13.0	35.9	5.0	3.5	6.0	1.8	2.8	0.8	-2.4
Leg predicted mass (right)	2.2	11.6	30.6	4.9	3.3	5.5	1.2	2.8	1.0	-2.3
Arm fat mass (left)	1.5	6.4	14.9	3.4	2.3	3.9	0.2	2.2	-0.3	-2.9
Number of self-reported non-cancer illnesses	0.2	0.4	1.0	-0.1	-0.3	1.0	0.8	0.7	0.1	-0.6
Average weekly champagne plus white wine intake	1.1	1.5	4.3	-0.2	-0.7	-0.1	1.3	-1.8	-0.9	2.1
Miserableness	2.1	3.7	9.9	2.6	0.9	3.1	1.6	0.8	1.9	-1.2
Guilty feelings	1.2	1.8	4.9	1.2	-0.9	1.4	2.2	1.3	1.1	-1.0
Wears glasses or contact lenses	3.8	4.4	8.7	2.5	2.6	3.0	2.2	0.8	0.4	-1.7
Ever taken oral contraceptive pill	1.1	1.2	5.0	-0.7	-0.9	-0.6	-0.8	0.1	2.2	1.2
Hearing aid user	0.9	1.0	2.9	-1.0	-1.1	-0.9	-1.7	-0.5	-0.3	0.8
Mother’s age at death	0.4	0.5	2.5	0.6	0.1	0.2	0.7	0.4	1.6	-0.2
Financial situation satisfaction	2.9	3.7	7.3	2.4	1.5	2.5	0.4	1.6	2.7	-1.2
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.8	-0.5	0.1	-0.1	0.7	-0.9	0.2	0.3
Commuting to job workplace: Public transport	2.7	3.2	15.9	2.1	-0.0	1.1	1.1	0.3	4.0	0.1
Eye problems/disorders: Glaucoma	0.2	0.3	0.7	0.1	0.6	0.9	0.1	0.5	0.2	-0.7
Medication: Blood pressure	0.5	0.9	3.6	-1.3	-0.4	0.0	0.8	-0.2	-1.9	-0.7
Pain type(s) experienced in last month: Hip pain	2.3	2.9	6.9	2.1	1.4	2.6	1.6	1.6	-0.1	-1.4
Supplements: Fish oil (including cod liver oil)	1.1	1.4	2.7	-1.5	-1.6	-1.2	-0.2	-0.9	0.6	1.5
High cholesterol (Self-reported)	0.2	0.4	1.6	-0.1	-0.1	0.2	0.5	-0.7	1.2	0.2
Medication: Bendroflumethiazide	3.2	4.9	9.9	-3.2	-2.7	-2.5	-0.5	-1.8	-1.5	2.3
Medication: Paracetamol	1.5	2.2	5.6	-1.4	-1.8	-0.8	-1.1	-1.7	-0.0	2.4
Medication: Lisinopril	0.3	0.4	1.3	-0.9	0.1	-0.7	-0.0	-1.2	-0.3	-0.0
Medication: Atorvastatin	0.3	0.4	1.6	-0.0	0.6	-0.0	0.9	0.1	-1.3	-0.4
Illnesses of father: High blood pressure	0.4	0.5	1.2	0.6	1.1	0.3	-0.4	0.5	-0.8	-1.0
Alcohol drinker status: Never	1.9	2.3	4.5	-1.8	-0.1	-2.1	-1.6	-0.9	-2.1	0.7
Ever smoked	1.7	3.0	7.0	2.6	1.1	2.5	-0.5	1.5	1.0	-1.7
Basal metabolic rate	2.5	13.6	36.8	5.2	3.6	6.1	1.7	2.8	0.3	-2.8
Leg fat percentage (left)	1.0	3.7	8.0	1.8	1.4	2.4	-0.6	1.0	-2.3	-2.8
Arm fat-free mass (left)	2.3	11.9	29.4	4.6	3.7	5.4	1.9	2.8	-0.0	-2.7
Number of operations (self-reported)	2.8	4.2	13.4	2.6	1.1	3.7	1.7	0.9	0.3	-2.0
Average weekly beer plus cider intake	2.2	3.1	6.1	-1.4	-2.2	-0.3	-2.5	-2.0	1.8	1.4
Irritability	0.8	1.3	3.7	1.1	-1.2	1.9	0.3	1.1	1.2	0.2
Risk taking	1.5	2.1	7.3	2.2	-0.6	2.7	1.0	0.9	-0.2	-0.9
Ever had prostate specific antigen (PSA) test	1.9	2.2	4.0	2.0	1.2	1.3	2.0	1.2	1.3	-1.2
Fractured/broken bones in last 5 years	0.1	0.1	0.9	-0.2	-0.0	0.2	-0.1	0.2	0.9	0.2
Age started oral contraceptive pill	0.4	0.5	1.5	0.9	1.2	0.5	-0.1	0.7	0.4	-0.8
Diastolic blood pressure, automated reading	0.7	2.0	5.0	0.4	-0.3	1.6	-0.9	2.2	-1.8	-1.5
Ever depressed for a whole week	3.1	3.8	8.6	2.6	0.9	2.9	1.2	2.3	1.1	-1.6
Unable to work because of sickness or disability	0.4	0.6	2.3	0.1	-0.1	0.1	-1.5	1.0	-0.4	-0.8
Commuting to job workplace: Cycle	0.6	0.7	2.6	1.0	1.6	0.2	0.8	-0.4	0.4	-0.6
Myopia	0.5	0.7	1.5	-1.2	-0.9	-0.8	-1.0	-0.5	-1.1	-0.1
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.7	1.3	0.6	-0.1	-0.6	-1.0	0.4	-0.2
Cholesterol lowering medication	0.4	0.6	1.1	-0.9	-0.2	-0.1	-0.9	0.5	-1.0	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	4.4	-0.8	-0.6	0.3	-2.1	-0.0	0.4	0.7
Pain experienced in last month	0.3	0.5	1.0	-0.6	0.7	-0.8	-1.0	0.0	-1.0	-0.4
Supplements: Calcium	1.0	1.1	3.8	-0.2	0.3	-1.2	-0.8	0.2	2.0	1.3
Basal cell carcinoma (self-reported)	0.3	0.4	1.3	-0.4	-0.2	-0.5	0.4	-0.9	-0.2	1.1
Heart attack/myocardial infarction (self-reported)	1.8	2.3	7.2	-1.7	-2.7	-0.7	-1.1	-1.5	-0.7	1.2
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.8	0.8	0.8	1.4	-0.3	-0.8	0.5	-0.1
Heart disease (siblings)	1.2	1.5	7.1	0.8	0.0	0.7	-2.7	0.9	0.8	-0.8
Alcohol drinker status: Previous	0.9	1.0	2.6	-0.0	0.0	-1.2	-0.7	-0.9	1.6	1.2
Pack years of smoking	0.5	0.7	3.8	-0.2	0.0	-0.4	-1.9	0.2	-0.9	0.2
Impedance of whole body	0.8	4.2	11.5	-2.4	-0.2	-3.4	-0.8	-1.6	-3.0	-0.4
Leg fat mass (left)	1.5	5.8	13.2	3.0	2.1	3.6	-0.1	1.8	-1.4	-2.9
Arm predicted mass (left)	2.7	13.5	34.2	4.9	3.8	5.8	2.1	2.9	0.3	-2.9