Best TWAS P=8.14e-21 · Best GWAS P=7.79e-20 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5 | GTEx | Testis | CDK6 | 0.10 | 0.10 | lasso | 3 | 0.09 | 8.0e-05 | 9.1 | -9.4 | 8.1e-21 | -0.96 | 0.01 | 0.99 | TRUE |
| 1 | CommonMind | Brain Pre-frontal Cortex | CDK6 | 0.12 | 0.10 | lasso | 2 | 0.10 | 1.9e-12 | 8.7 | 8.7 | 3.2e-18 | 0.89 | 0.02 | 0.98 | FALSE |
| 4 | GTEx | Esophagus Muscularis | FAM133B | 0.07 | 0.01 | enet | 2 | 0.01 | 1.2e-01 | -6.0 | -6.1 | 1.4e-09 | -0.55 | 0.07 | 0.32 | FALSE |
| 6 | YFS | Blood | GATAD1 | 0.01 | 0.01 | blup | 297 | 0.01 | 5.1e-04 | 3.9 | -5.6 | 2.0e-08 | -0.53 | 0.74 | 0.09 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | GATAD1 | 0.23 | 0.20 | lasso | 4 | 0.22 | 1.4e-16 | 3.9 | -5.3 | 1.1e-07 | -0.69 | 0.93 | 0.07 | FALSE |
| 2 | GTEx | Brain Caudate basal ganglia | GATAD1 | 0.21 | 0.09 | lasso | 4 | 0.08 | 2.3e-03 | 4.4 | -5.2 | 2.2e-07 | -0.56 | 0.06 | 0.45 | FALSE |