Hub : Genes

CDK6

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.120 0.034 1.0e-07 0.105 0.066 0.096 0.081 0.103 1.0e-12 1.7e-08 9.8e-12 4.1e-10 1.9e-12
2 GTEx Esophagus Gastroesophageal Junction 0.214 0.086 9.9e-03 -0.007 NA 0.008 NA -0.002 6.8e-01 NA 1.6e-01 NA 4.0e-01
3 GTEx Testis 0.101 0.042 2.2e-03 0.102 NA 0.089 NA 0.091 2.9e-05 NA 9.1e-05 NA 8.0e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 1.0 1.6 3.1 0.4 1.8 1.2
Bipolar Disorder or Schizophrenia 0.2 0.6 1.1 0.3 1.1 0.7
Depressed Affect (Nagel 2018) 0.3 0.5 0.9 -0.3 -0.8 1.0
Depression (Nagel 2018) 0.3 0.4 1.0 0.1 1.0 0.4
Intelligence (Savage-Jansen 2018) 0.5 1.6 2.7 -1.6 -0.1 1.5
Neuroticism (Nagel 2018) 0.2 0.5 0.7 -0.3 -0.8 0.9
Schizophrenia (2018) 0.0 0.0 0.0 0.1 -0.1 -0.1
Schizophrenia vs Biploar Disorder 0.3 0.4 1.1 0.2 -1.1 -0.3
Worry (Nagel 2018) 0.3 0.7 0.9 -0.4 -1.0 0.9
Alzheimer’s Disease (in mother) 1.0 1.1 2.6 0.7 -0.6 -1.6
Alzheimer’s Disease (in father) 0.8 0.9 1.3 -1.1 1.2 0.5
Alzheimer’s Disease (including proxy) 0.2 0.2 0.6 -0.8 0.3 0.0
Crohns Disease (2017) 2.6 5.8 6.8 -2.6 -2.1 2.4
Irritable Bowel Disease (IBD) 2.5 6.0 9.0 -2.5 -1.6 3.0
Ulcerative Colitis (UC) 1.5 2.8 5.4 -1.4 -1.1 2.3
Major Depression (MDD) 1.0 1.2 1.8 -0.9 1.0 1.4
Reaction Time 0.3 0.5 1.1 -0.6 1.0 -0.0
Verbal and Numeric Reasoning (VNR) 0.7 1.8 3.0 -1.5 -0.1 1.7
Breast Cancer 3.0 7.2 13.1 -3.6 0.7 2.8
Ovarian Cancer 1.9 2.5 4.3 -1.3 1.2 2.1
Prostate Cancer 0.3 0.5 0.8 0.4 -0.7 -0.9
Age at First Birth 3.1 4.4 6.2 2.3 1.3 -2.5
Bipolar Disorder (2011) 1.3 1.2 3.3 0.4 1.8 -0.4
Body Mass Index (BMI) (2010) 0.3 0.3 0.6 -0.6 -0.1 0.8
Coronary Artery Disease (CAD) 0.6 0.8 1.7 -0.6 0.4 1.3
Crohns Disease (2012) 3.3 5.3 6.2 -2.2 -2.5 2.2
Mean Putamen Volume 0.2 0.2 0.4 0.3 0.4 -0.7
Fasting Glucose 0.6 0.7 1.3 -0.8 -1.1 -0.3
HbA1C 1.7 1.9 4.2 -2.1 0.7 1.0
HDL Cholesterol 0.2 0.4 0.8 0.9 0.5 -0.5
LDL Cholesterol 4.6 7.3 9.6 -2.8 2.1 3.1
Lupus 3.2 4.8 14.3 -0.2 3.8 0.0
Neuroticism (2016) 3.4 4.8 6.6 -2.5 1.3 2.6
Primary Biliary Cirrhosis 0.2 0.3 0.6 -0.3 0.8 0.5
Rheumatoid Arthritis 8.7 12.0 18.2 4.1 -1.0 -4.3
Schizophrenia (2014) 0.1 0.2 0.3 0.2 0.6 0.3
Triglycerides 2.2 3.7 5.2 -2.2 0.9 2.3
Type 2 Diabetes (T2D) (2012) 1.3 1.5 3.3 -1.0 1.8 -0.5
Ulcerative Colitis 1.3 1.9 2.4 -1.0 -1.5 1.5
Blood Eosinophil Count 6.7 51.2 61.8 7.9 -6.5 -7.0
Blood Platelet Count 2.5 28.5 46.6 -5.9 1.9 6.8
Blood Red Count 0.4 4.1 8.1 -1.6 -2.8 1.3
Blood White Count 4.8 35.4 56.6 5.3 -7.5 -4.6
Heel T-Score 12.9 103.0 163.8 -11.9 1.9 12.8
BMI 0.4 2.4 5.0 1.4 -0.0 -2.2
Height 39.2 754.7 1176.5 32.9 -2.3 -34.3
Waist Hip Ratio (WHR) 0.9 3.9 5.1 -2.2 -1.9 1.8
Systolic Blood Pressure 12.3 61.7 100.0 -8.4 3.8 10.0
Smoking Status 1.6 3.8 5.3 1.9 1.5 -2.3
Allergy or Eczema 0.4 1.0 1.5 -1.0 -1.2 0.6
Cardiovascular Disease 4.6 15.1 24.6 -4.1 1.9 5.0
Hypothyroidism (self reported) 1.6 3.6 6.4 2.0 -0.5 -2.5
Respiratory disease 1.3 2.8 4.6 2.1 1.3 -1.5
Type 2 Diabetes (T2D) (2018) 2.4 4.5 7.7 -2.8 0.8 2.3
Lung FEV1/FVC ratio 0.2 0.9 2.3 -1.5 0.1 0.7
Lung FVC 0.9 4.3 5.2 -2.2 1.7 2.3
Neuroticism 0.5 1.1 1.4 -0.8 -1.2 1.2
Chronotype (morning person) 0.1 0.1 0.2 -0.4 -0.4 0.3
Hair Pigment 0.0 1.1 2.5 0.1 -1.6 0.9
Tanning 0.0 0.4 0.5 -0.7 -0.6 0.6
Hand grip strength (left) 2.2 5.7 9.0 3.0 0.9 -2.7
Number of treatments/medications taken 0.4 0.6 1.3 -0.2 -1.2 0.7
Average weekly spirits intake 0.2 0.2 0.5 0.7 -0.3 -0.2
Sensitivity / hurt feelings 2.5 4.2 6.9 -2.1 1.3 2.6
Frequency of depressed mood in last 2 weeks 0.9 1.3 3.0 1.0 1.7 -0.1
Hearing difficulty/problems: Yes 2.0 3.1 5.0 2.2 0.0 -2.1
Relative age of first facial hair 0.5 1.1 2.6 0.8 -1.6 -0.2
Other serious medical condition/disability diagnosed by doctor 2.1 2.8 3.2 1.8 1.8 -1.4
Ever used hormone-replacement therapy (HRT) 0.1 0.1 0.2 0.4 0.2 0.2
Ever had hysterectomy (womb removed) 1.3 1.5 2.4 -1.3 -0.6 1.5
Systolic blood pressure, automated reading 11.7 33.9 59.6 -6.0 2.4 7.7
Eye problems/disorders: Diabetes related eye disease 1.6 1.7 1.9 -1.2 -1.3 1.4
Angina 0.5 0.7 0.9 -1.0 -0.8 0.7
Medication for hormone replacement therapy 3.6 4.0 6.2 2.4 0.4 -2.5
Vitamin and mineral supplements 1.4 1.8 1.9 -1.3 1.4 1.4
Supplements: Zinc 1.0 1.1 1.3 1.0 -1.0 -1.2
Medication: Co-codamol 0.1 0.1 0.2 -0.4 0.2 0.4
Medication: Metformin 1.5 2.1 2.9 -1.7 0.8 1.7
Diabetes (father) 1.4 1.8 3.0 -1.7 1.3 0.9
Diabetes (mother) 3.7 4.8 6.2 -2.0 -2.5 2.0
Severe depression (siblings) 0.3 0.3 0.8 0.0 -0.3 -0.9
Pack years adult smoking proportion 0.3 0.4 0.5 0.6 -0.7 -0.7
Impedance of leg (right) 2.3 11.0 19.4 -3.7 0.1 4.4
Leg fat-free mass (left) 26.3 139.5 222.0 14.0 -0.7 -14.9
Trunk fat percentage 2.3 9.1 14.8 3.5 -0.2 -3.8
Hand grip strength (right) 2.8 7.6 12.2 3.5 1.0 -3.1
Townsend deprivation index at recruitment 3.5 4.9 7.3 2.7 0.3 -2.7
Current tobacco smoking 1.3 2.2 3.0 1.6 0.9 -1.7
Average weekly fortified wine intake 0.7 0.8 1.6 0.7 -0.6 -1.3
Maternal smoking around birth 1.8 2.6 4.7 2.2 -0.5 -1.7
Fed-up feelings 0.1 0.1 0.3 0.5 -0.3 -0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.4 1.7 1.3 1.1 -1.2
Relative age voice broke 0.9 1.3 2.0 1.3 -1.4 -0.7
Taking other prescription medications 0.4 0.6 1.1 1.1 -0.4 -0.7
Age when periods started (menarche) 0.2 0.5 1.0 1.0 0.3 -0.5
Bilateral oophorectomy (both ovaries removed) 3.2 3.7 4.5 -1.6 -2.0 2.1
Heel bone mineral density (BMD) T-score, automated (left) 7.1 16.0 29.4 -4.3 0.7 5.4
Tinnitus: Yes, but not now, but have in the past 0.8 0.9 1.4 1.2 0.1 -1.1
Qualifications: CSEs or equivalent 4.6 6.0 9.8 3.1 1.7 -2.3
Serious illness, injury or assault to yourself 0.6 0.7 1.8 0.2 1.4 -0.5
High blood pressure 2.1 6.0 10.6 -2.4 1.3 3.3
Hayfever, allergic rhinitis or eczema 0.2 0.5 1.5 -0.2 -1.2 -0.2
Multivitamins +/- minerals 1.2 1.5 1.7 1.3 -1.1 -1.3
Stomach or abdominal pain in last month 2.2 2.8 5.4 -0.7 2.3 1.5
Supplements: Glucosamine 0.9 1.2 2.0 1.4 0.2 -1.2
Diverticular disease/diverticulitis (self-reported) 1.5 1.8 5.2 -0.2 -2.3 0.4
Medication: Atenolol 0.1 0.1 0.3 0.3 -0.5 0.0
Medication: Levothyroxine sodium 1.0 1.7 2.4 1.4 -0.9 -1.5
Sitting height 27.2 192.8 302.8 16.6 -0.5 -17.4
Chronic bronchitis/emphysema (father) 0.9 1.0 2.1 1.4 -0.0 -1.0
High blood pressure (mother) 1.0 1.5 2.4 -1.5 0.3 1.4
Body mass index (BMI) 0.6 2.5 4.6 1.7 -0.1 -2.1
Impedance of leg (left) 2.2 10.8 18.1 -3.8 0.2 4.3
Leg predicted mass (left) 26.5 140.5 225.0 14.0 -0.6 -15.0
Trunk fat mass 9.6 41.1 67.1 7.5 -0.3 -8.2
Waist circumference 5.8 21.3 34.9 5.3 -0.5 -5.9
Number of incorrect matches in round 0.4 0.6 1.2 0.8 -0.1 -1.1
Past tobacco smoking 1.0 1.8 3.0 -1.6 -0.2 1.7
Alcohol usually taken with meals 1.3 2.1 3.9 -2.0 -0.3 1.5
Nervous feelings 1.2 2.2 3.5 -1.7 0.1 1.9
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.7 1.3 1.1 0.3 -0.9
Hearing difficulty/problems with background noise 3.5 5.6 10.0 2.6 -0.3 -3.2
Hair/balding pattern: Pattern 2 1.3 1.7 2.2 -1.2 1.5 1.2
Had menopause 0.7 0.8 1.4 -1.0 -0.1 1.2
Had other major operations 0.2 0.2 0.3 -0.4 -0.5 0.4
Forced vital capacity (FVC) 8.3 32.1 52.8 6.5 1.0 -7.3
Heel bone mineral density (BMD) T-score, automated (right) 9.4 21.5 38.2 -5.0 1.1 6.2
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 1.6 -0.7 1.2 0.4
Qualifications: None of the above 1.4 3.0 4.4 2.0 -0.9 -2.1
Financial difficulties in last 2 years 1.4 1.9 5.6 -0.2 2.4 -0.0
Mouth/teeth dental problems 0.3 0.4 0.9 -0.1 -1.0 0.5
Heart attack 0.2 0.3 0.6 -0.8 0.4 -0.3
Allergy 0.4 1.0 1.5 -0.8 0.9 1.2
Pain all over the body in last month 1.2 1.3 1.6 1.3 -1.0 -1.1
Diabetes (self-reported) 1.4 2.2 3.8 -1.9 -0.0 1.7
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 1.5 -0.3 -1.0 1.2
Medication: Ramipril 0.2 0.3 0.7 -0.8 -0.3 -0.1
Medication: Simvastatin 1.1 1.6 2.6 -1.5 0.4 1.6
Fluid intelligence score 1.0 2.0 2.7 -1.6 1.0 1.5
Illnesses of siblings 3.1 4.4 6.9 2.6 0.5 -2.5
Neuroticism score 0.2 0.5 1.0 -0.7 -0.1 1.0
Weight 19.4 95.4 153.8 11.5 -0.5 -12.4
Impedance of arm (right) 0.3 1.4 2.3 -1.1 -0.9 1.5
Arm fat percentage (right) 0.5 2.1 3.8 1.6 -0.3 -1.9
Trunk fat-free mass 35.4 203.2 324.0 16.9 -0.4 -18.0
Hip circumference 12.7 54.5 87.6 8.7 -0.3 -9.4
Time employed in main current job 0.5 0.6 0.9 0.7 0.9 -0.5
Alcohol intake versus 10 years previously 0.3 0.4 0.5 0.7 0.7 -0.5
Father’s age at death 0.9 1.2 1.7 1.0 1.3 -0.9
Worrier / anxious feelings 0.9 1.6 2.8 -1.4 0.0 1.7
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.3 2.5 1.1 0.4 -1.6
Falls in the last year 0.6 0.7 2.0 0.4 0.4 -1.4
Hair/balding pattern: Pattern 3 0.6 0.9 1.4 1.2 -0.5 -1.1
Number of live births 1.0 1.4 2.6 -1.1 0.6 1.6
Forced expiratory volume in 1-second (FEV1) 5.2 17.4 30.2 4.6 0.9 -5.5
Pulse rate 0.2 0.3 0.9 0.2 -0.9 -0.2
Happiness 0.3 0.3 0.5 -0.6 0.4 0.7
Noisy workplace 0.2 0.3 0.4 0.5 0.6 -0.5
Qualifications: A levels/AS levels or equivalent 1.9 4.3 7.0 -2.6 1.3 2.1
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 1.7 -0.8 1.3 0.4
Mouth/teeth dental problems: Dentures 0.0 0.0 0.1 0.1 0.1 0.2
Asthma 0.9 1.7 2.7 1.6 -0.0 -1.6
Medication: Ibuprofen (e.g. Nurofen) 5.8 7.4 11.8 3.4 -0.6 -3.2
Medication: Cholesterol lowering 0.6 1.0 1.7 -1.0 0.6 1.3
Depression (self-reported) 1.0 1.2 1.7 -1.3 -0.4 1.3
Medication: Lansoprazole 0.9 1.1 1.4 -1.2 -0.7 1.1
Prospective memory result 0.1 0.1 0.1 -0.2 -0.4 -0.1
Lung cancer (father) 1.9 2.3 4.0 1.6 -0.6 -2.0
Illnesses of mother 0.4 0.5 1.1 0.5 1.0 -0.2
Forced expiratory volume in 1-second (FEV1), Best measure 4.3 13.7 23.1 4.1 1.0 -4.8
Pulse wave Arterial Stiffness index 3.3 3.8 5.7 2.2 1.0 -2.4
Impedance of arm (left) 1.3 5.9 8.5 -2.6 -1.5 2.9
Arm fat mass (right) 6.5 26.6 44.1 6.0 -0.4 -6.6
Trunk predicted mass 35.4 202.0 320.4 16.9 -0.3 -17.9
Standing height 35.6 353.2 552.2 22.5 -1.1 -23.5
Length of working week for main job 3.1 3.4 5.6 -2.4 0.6 2.1
Exposure to tobacco smoke at home 1.2 1.4 2.2 1.0 -1.5 -1.0
Breastfed as a baby 0.5 0.6 0.9 0.8 0.9 -0.5
Tense / ‘highly strung’ 0.3 0.6 0.7 0.6 -0.8 -0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 1.0 -1.0 -0.6 0.7
Hair/balding pattern: Pattern 4 1.1 2.6 3.8 -1.9 1.3 1.5
Birth weight of first child 0.4 0.8 1.9 0.5 1.4 -0.4
Peak expiratory flow (PEF) 3.5 8.1 13.0 3.1 1.2 -3.6
Pulse wave reflection index 2.3 2.8 3.1 1.7 1.5 -1.8
Ever highly irritable/argumentative for 2 days 0.5 0.6 1.5 -0.4 1.2 0.4
Loud music exposure frequency 0.8 0.8 1.8 1.3 0.1 -0.9
Qualifications: O levels/GCSEs or equivalent 0.5 0.9 1.4 -1.2 0.5 1.0
Mouth/teeth dental problems: Bleeding gums 2.1 2.8 4.9 1.8 0.3 -2.2
Blood clot in the leg (DVT) 0.5 0.7 1.2 0.9 -0.1 -1.1
Medication: Paracetamol 3.0 5.1 7.2 2.4 -1.4 -2.7
Headache pain in last month 2.0 3.4 5.1 2.3 -1.7 -1.5
Medication for cholesterol, blood pressure or diabetes 1.5 2.5 3.5 1.9 -0.8 -1.8
Glaucoma (self-reported) 0.6 0.7 1.1 1.1 0.8 -0.5
Gout (self-reported) 1.8 2.4 3.3 1.8 -0.9 -1.8
Hypothyroidism/myxoedema (self-reported) 2.6 5.1 7.6 2.2 -1.7 -2.7
Medication: Amlodipine 5.2 7.3 11.8 -3.1 0.4 3.4
Medication: Ventolin 100micrograms inhaler 0.1 0.2 0.3 0.6 0.0 -0.5
Birth weight 6.1 13.3 20.0 4.5 -0.4 -4.5
Chronic bronchitis/emphysema (mother) 0.2 0.3 0.4 0.6 -0.1 -0.7
High blood pressure (siblings) 0.8 1.2 1.9 -1.4 -0.4 1.2
Forced vital capacity (FVC), Best measure 7.8 28.6 46.0 6.2 0.9 -6.8
Body fat percentage 1.0 3.8 6.5 2.2 -0.1 -2.5
Leg fat percentage (right) 0.0 0.0 0.0 -0.1 -0.0 -0.1
Arm fat-free mass (right) 26.4 135.6 219.0 13.7 -0.2 -14.8
Exposure to tobacco smoke outside home 1.9 2.5 3.5 1.5 -1.9 -1.4
Comparative body size at age 10 0.2 0.4 0.8 -0.7 0.9 0.2
Number of full brothers 0.6 0.7 1.0 1.0 0.9 -0.5
Worry too long after embarrassment 0.6 1.0 1.4 1.2 1.0 -0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.7 1.3 -1.1 0.0 0.9
Wheeze or whistling in the chest in last year 0.6 1.1 2.2 -0.7 1.5 0.7
Number of children fathered 1.1 1.2 1.7 -1.0 0.9 1.3
Reason for reducing amount of alcohol drunk: Health precaution 1.2 1.4 3.9 0.1 -2.0 0.4
Age at first live birth 0.1 0.2 0.5 -0.7 0.1 0.5
Pulse wave peak to peak time 0.6 0.7 1.1 -0.6 -1.0 0.8
Health satisfaction 0.5 0.6 0.9 -0.9 0.8 0.5
Shortness of breath walking on level ground 0.8 1.0 2.0 0.9 0.4 -1.4
Qualifications: College or University degree 0.8 2.6 4.1 -2.0 1.1 1.6
Eye problems/disorders: None of the above 0.3 0.4 0.7 -0.8 -0.5 0.4
Mouth/teeth dental problems: Loose teeth 0.0 0.0 0.0 -0.0 -0.1 0.0
Emphysema/chronic bronchitis 2.2 2.5 4.4 2.1 -0.3 -1.8
Medication for pain relief, constipation, heartburn 1.1 1.9 2.4 -1.6 1.2 1.3
Neck or shoulder pain in last month 1.1 1.6 2.5 1.6 0.9 -1.3
Medication: Blood pressure 0.4 0.7 0.8 -0.9 0.6 0.9
Angina (self-reported) 0.5 0.6 0.9 -0.9 -0.7 0.6
Migraine (self-reported) 4.9 6.1 10.7 3.3 0.2 -2.7
Medication: Ibuprofen 4.3 5.2 7.9 2.8 -0.2 -2.8
Medication: Allopurinol 1.0 1.3 1.7 1.3 -0.8 -1.3
Medication: Omeprazole 6.4 7.7 11.8 -3.3 0.4 3.4
Medication: Seretide 50 evohaler 0.1 0.1 0.3 -0.2 0.6 0.1
Mean time to correctly identify matches 0.1 0.1 0.2 -0.2 0.4 -0.3
Heart disease (mother) 1.1 1.3 3.9 -0.0 -2.0 -0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 1.8 -1.3 -0.6 1.3
Whole body fat mass 8.0 33.2 54.8 6.7 -0.3 -7.4
Leg fat mass (right) 5.1 19.7 33.1 5.1 -0.3 -5.8
Arm predicted mass (right) 27.4 140.3 225.0 14.0 -0.1 -15.0
Pulse rate, automated reading 0.2 0.7 2.0 0.2 -1.4 0.3
Alcohol intake frequency. 1.0 2.4 3.8 1.9 0.5 -1.8
Comparative height size at age 10 29.7 163.4 252.8 15.4 -0.5 -15.9
Number of full sisters 1.4 1.8 2.5 -1.6 0.6 1.6
Suffer from ‘nerves’ 0.1 0.2 0.3 0.5 0.4 -0.2
Overall health rating 0.1 0.2 0.5 0.2 0.7 -0.1
Chest pain or discomfort 0.1 0.1 0.3 -0.3 0.5 0.2
Had major operations 0.5 0.6 1.0 0.8 0.4 -1.0
Age at last live birth 1.0 1.4 1.9 -1.3 0.8 1.4
Family relationship satisfaction 1.6 2.0 2.8 -1.4 -1.1 1.7
Leg pain on walking 0.6 0.8 1.5 0.8 -0.6 -1.2
Qualifications: NVQ or HND or HNC or equivalent 0.0 0.1 0.1 -0.0 0.3 0.3
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.4 -0.1 -0.6 0.6
Illness, injury, bereavement, stress in last 2 years 3.0 3.6 7.4 -1.2 -2.7 1.5
Medication: Aspirin 1.7 2.3 3.8 -1.7 -0.3 1.9
Supplements: Vitamin C 1.9 2.3 3.0 1.7 -1.2 -1.6
Knee pain experienced in last month 0.7 1.1 2.5 0.7 -1.6 -0.4
Hypertension (Self-reported) 2.4 6.6 11.1 -2.5 1.6 3.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 1.5 -0.8 -0.6 1.2
Illnesses of father: Heart disease 4.3 5.9 9.4 -2.8 0.7 3.1
Illnesses of siblings: Diabetes 3.7 4.6 7.0 -2.6 -0.3 2.6
Smoking status: Previous 0.1 0.2 0.3 0.3 -0.3 -0.5
Forced expiratory volume in 1-second (FEV1), predicted 15.7 32.6 48.0 6.9 1.5 -6.9
Whole body fat-free mass 32.4 185.1 295.8 16.1 -0.3 -17.2
Leg fat-free mass (right) 26.6 142.4 228.0 14.1 -0.5 -15.1
Arm fat percentage (left) 0.2 0.9 1.6 0.8 -0.6 -1.3
Average weekly red wine intake 2.3 3.4 5.4 -2.3 -1.1 1.9
Handedness (chirality/laterality): Left-handed 0.0 0.0 0.1 -0.3 0.2 -0.1
Mood swings 0.6 1.2 2.2 -1.0 0.4 1.5
Loneliness, isolation 0.2 0.3 0.5 0.6 -0.7 -0.3
Long-standing illness, disability or infirmity 0.2 0.3 0.6 0.7 -0.1 -0.5
Ever had bowel cancer screening 4.5 5.3 7.3 2.3 -2.7 -1.8
Diabetes diagnosed by doctor 1.5 2.4 4.0 -2.0 0.6 1.7
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.1 2.1 1.0 -0.2 -1.5
Friendships satisfaction 0.4 0.5 0.6 -0.6 -0.7 0.7
Qualifications: nursing, teaching 0.0 0.0 0.0 0.2 0.2 -0.0
Commuting to job workplace: Walk 0.0 0.0 0.1 -0.1 0.3 -0.0
Eye problems/disorders: Cataract 0.5 0.6 0.7 0.9 0.5 -0.8
Mouth/teeth dental problems: Mouth ulcers 5.1 8.1 10.8 -3.3 2.6 2.6
Medication for cholesterol 2.6 4.0 6.2 1.9 1.5 -2.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.0 2.4 3.2 1.8 1.0 -1.7
Back pain experienced in last month 2.8 4.1 6.8 2.3 -0.5 -2.6
Mineral and other dietary supplements 0.6 0.8 1.3 -1.2 0.7 0.7
Breast cancer (self-reported) 0.5 0.6 1.6 -0.1 -1.3 -0.1
Asthma (self-reported) 0.8 1.5 2.3 1.5 0.0 -1.5
Osteoporosis (self-reported) 1.3 1.6 3.3 -1.2 -0.1 1.8
Osteoarthritis (self-reported) 0.1 0.1 0.2 -0.3 0.2 0.5
Medication: Aspirin 1.3 1.7 2.7 -1.4 -0.6 1.6
Medication: Gliclazide 3.2 3.6 5.0 -1.2 2.2 2.0
Illnesses of father: None of the above (group 1) 6.2 7.7 12.9 3.2 -0.1 -3.6
Smoking status: Current 1.9 3.0 4.4 2.1 0.7 -2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.3 1.8 -1.3 0.7 1.3
Whole body water mass 31.5 179.6 285.6 15.9 -0.5 -16.9
Leg predicted mass (right) 26.9 143.4 231.0 14.1 -0.6 -15.2
Arm fat mass (left) 5.8 23.6 39.5 5.6 -0.6 -6.3
Number of self-reported non-cancer illnesses 0.4 0.7 1.9 1.4 0.3 -0.5
Average weekly champagne plus white wine intake 0.8 1.1 2.0 1.0 1.4 -0.4
Miserableness 0.1 0.1 0.3 0.1 0.6 0.2
Guilty feelings 0.4 0.6 0.8 0.8 0.9 -0.6
Wears glasses or contact lenses 0.5 0.6 0.9 -1.0 -0.1 0.9
Ever taken oral contraceptive pill 1.8 2.1 2.8 -1.7 -0.8 1.7
Hearing aid user 1.8 2.0 2.9 1.7 0.6 -1.7
Mother’s age at death 1.3 1.6 2.1 1.2 -1.2 -1.4
Financial situation satisfaction 0.3 0.3 0.9 0.4 -0.9 -0.2
Tinnitus: Yes, now most or all of the time 0.6 0.7 1.4 -1.2 0.2 0.8
Commuting to job workplace: Public transport 1.1 1.3 3.4 -0.0 1.9 -0.7
Eye problems/disorders: Glaucoma 0.3 0.3 0.8 -0.1 -0.9 0.3
Medication: Blood pressure 3.6 6.8 12.0 -2.7 -1.1 3.5
Pain type(s) experienced in last month: Hip pain 0.8 1.0 2.9 -0.1 1.7 0.0
Supplements: Fish oil (including cod liver oil) 0.4 0.5 0.8 0.9 -0.8 -0.4
High cholesterol (Self-reported) 2.1 3.7 6.6 -2.1 -0.5 2.6
Medication: Bendroflumethiazide 1.2 1.8 3.4 -1.8 -0.2 1.4
Medication: Paracetamol 1.6 2.4 2.6 1.6 -1.5 -1.6
Medication: Lisinopril 2.0 2.6 4.0 -2.0 -0.1 2.0
Medication: Atorvastatin 3.4 4.2 6.7 -2.6 0.4 2.4
Illnesses of father: High blood pressure 2.5 3.1 6.2 -1.8 -0.0 2.5
Alcohol drinker status: Never 0.4 0.4 0.8 0.5 -0.5 -0.9
Ever smoked 1.0 1.7 2.6 1.2 0.9 -1.6
Basal metabolic rate 30.3 167.7 269.0 15.3 -0.4 -16.4
Leg fat percentage (left) 0.0 0.1 0.1 -0.1 0.2 -0.3
Arm fat-free mass (left) 29.6 150.1 237.2 14.6 0.1 -15.4
Number of operations (self-reported) 0.7 1.0 1.9 1.4 -0.5 -0.9
Average weekly beer plus cider intake 0.0 0.0 0.0 -0.1 0.2 -0.0
Irritability 0.6 1.0 1.4 1.2 -0.6 -1.1
Risk taking 0.7 1.1 1.8 1.2 -0.1 -1.3
Ever had prostate specific antigen (PSA) test 0.7 0.8 1.0 -0.7 1.0 1.0
Fractured/broken bones in last 5 years 3.8 4.9 7.5 2.6 0.4 -2.7
Age started oral contraceptive pill 0.6 0.8 1.3 -1.2 -0.6 0.8
Diastolic blood pressure, automated reading 0.9 2.9 7.4 2.7 0.0 -1.2
Ever depressed for a whole week 0.1 0.1 0.1 -0.2 0.3 0.4
Unable to work because of sickness or disability 0.4 0.5 0.7 0.8 0.6 -0.6
Commuting to job workplace: Cycle 1.4 1.7 2.8 -1.5 0.4 1.7
Myopia 2.1 3.1 4.8 1.3 -1.7 -2.2
Vascular/heart problems diagnosed by doctor 2.1 5.6 9.9 2.3 -1.2 -3.1
Cholesterol lowering medication 5.1 7.5 11.9 -3.1 -0.9 3.5
Medication: Omeprazole (e.g. Zanprol) 5.0 6.1 9.7 -2.9 0.3 3.1
Pain experienced in last month 3.1 5.2 9.1 -3.0 0.7 2.5
Supplements: Calcium 0.1 0.2 0.2 -0.1 -0.5 -0.5
Basal cell carcinoma (self-reported) 0.8 0.9 1.9 1.4 0.2 -0.9
Heart attack/myocardial infarction (self-reported) 0.2 0.2 0.4 -0.6 0.3 -0.4
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 0.6 0.6 -0.6 -0.8
Heart disease (siblings) 2.3 2.8 4.2 -2.0 -1.7 1.1
Alcohol drinker status: Previous 0.3 0.3 0.6 0.8 0.1 -0.6
Pack years of smoking 0.5 0.8 1.0 0.9 -1.0 -0.7
Impedance of whole body 1.8 9.1 15.1 -3.4 -0.8 3.9
Leg fat mass (left) 5.4 21.3 36.0 5.3 -0.2 -6.0
Arm predicted mass (left) 29.3 149.1 237.2 14.5 -0.1 -15.4