TWAS hub - CDK6

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.120	0.034	1.0e-07	0.105	0.066	0.096	0.081	0.103	1.0e-12	1.7e-08	9.8e-12	4.1e-10	1.9e-12
2	GTEx	Esophagus Gastroesophageal Junction	0.214	0.086	9.9e-03	-0.007	NA	0.008	NA	-0.002	6.8e-01	NA	1.6e-01	NA	4.0e-01
3	GTEx	Testis	0.101	0.042	2.2e-03	0.102	NA	0.089	NA	0.091	2.9e-05	NA	9.1e-05	NA	8.0e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Height	39.2	754.7	1176.5	32.9	-2.3	-34.3
Standing height	35.6	353.2	552.2	22.5	-1.1	-23.5
Trunk fat-free mass	35.4	203.2	324.0	16.9	-0.4	-18.0
Trunk predicted mass	35.4	202.0	320.4	16.9	-0.3	-17.9
Whole body fat-free mass	32.4	185.1	295.8	16.1	-0.3	-17.2
Whole body water mass	31.5	179.6	285.6	15.9	-0.5	-16.9
Basal metabolic rate	30.3	167.7	269.0	15.3	-0.4	-16.4
Comparative height size at age 10	29.7	163.4	252.8	15.4	-0.5	-15.9
Arm fat-free mass (left)	29.6	150.1	237.2	14.6	0.1	-15.4
Arm predicted mass (left)	29.3	149.1	237.2	14.5	-0.1	-15.4
Arm predicted mass (right)	27.4	140.3	225.0	14.0	-0.1	-15.0
Sitting height	27.2	192.8	302.8	16.6	-0.5	-17.4
Leg predicted mass (right)	26.9	143.4	231.0	14.1	-0.6	-15.2
Leg fat-free mass (right)	26.6	142.4	228.0	14.1	-0.5	-15.1
Leg predicted mass (left)	26.5	140.5	225.0	14.0	-0.6	-15.0
Arm fat-free mass (right)	26.4	135.6	219.0	13.7	-0.2	-14.8
Leg fat-free mass (left)	26.3	139.5	222.0	14.0	-0.7	-14.9
Weight	19.4	95.4	153.8	11.5	-0.5	-12.4
Forced expiratory volume in 1-second (FEV1), predicted	15.7	32.6	48.0	6.9	1.5	-6.9
Heel T-Score	12.9	103.0	163.8	-11.9	1.9	12.8
Hip circumference	12.7	54.5	87.6	8.7	-0.3	-9.4
Systolic Blood Pressure	12.3	61.7	100.0	-8.4	3.8	10.0
Systolic blood pressure, automated reading	11.7	33.9	59.6	-6.0	2.4	7.7
Trunk fat mass	9.6	41.1	67.1	7.5	-0.3	-8.2
Heel bone mineral density (BMD) T-score, automated (right)	9.4	21.5	38.2	-5.0	1.1	6.2
Rheumatoid Arthritis	8.7	12.0	18.2	4.1	-1.0	-4.3
Forced vital capacity (FVC)	8.3	32.1	52.8	6.5	1.0	-7.3
Whole body fat mass	8.0	33.2	54.8	6.7	-0.3	-7.4
Forced vital capacity (FVC), Best measure	7.8	28.6	46.0	6.2	0.9	-6.8
Heel bone mineral density (BMD) T-score, automated (left)	7.1	16.0	29.4	-4.3	0.7	5.4
Blood Eosinophil Count	6.7	51.2	61.8	7.9	-6.5	-7.0
Arm fat mass (right)	6.5	26.6	44.1	6.0	-0.4	-6.6
Medication: Omeprazole	6.4	7.7	11.8	-3.3	0.4	3.4
Illnesses of father: None of the above (group 1)	6.2	7.7	12.9	3.2	-0.1	-3.6
Birth weight	6.1	13.3	20.0	4.5	-0.4	-4.5
Waist circumference	5.8	21.3	34.9	5.3	-0.5	-5.9
Medication: Ibuprofen (e.g. Nurofen)	5.8	7.4	11.8	3.4	-0.6	-3.2
Arm fat mass (left)	5.8	23.6	39.5	5.6	-0.6	-6.3
Leg fat mass (left)	5.4	21.3	36.0	5.3	-0.2	-6.0
Forced expiratory volume in 1-second (FEV1)	5.2	17.4	30.2	4.6	0.9	-5.5
Medication: Amlodipine	5.2	7.3	11.8	-3.1	0.4	3.4
Leg fat mass (right)	5.1	19.7	33.1	5.1	-0.3	-5.8
Mouth/teeth dental problems: Mouth ulcers	5.1	8.1	10.8	-3.3	2.6	2.6
Cholesterol lowering medication	5.1	7.5	11.9	-3.1	-0.9	3.5
Medication: Omeprazole (e.g. Zanprol)	5.0	6.1	9.7	-2.9	0.3	3.1
Migraine (self-reported)	4.9	6.1	10.7	3.3	0.2	-2.7
Blood White Count	4.8	35.4	56.6	5.3	-7.5	-4.6
LDL Cholesterol	4.6	7.3	9.6	-2.8	2.1	3.1
Cardiovascular Disease	4.6	15.1	24.6	-4.1	1.9	5.0
Qualifications: CSEs or equivalent	4.6	6.0	9.8	3.1	1.7	-2.3
Ever had bowel cancer screening	4.5	5.3	7.3	2.3	-2.7	-1.8
Forced expiratory volume in 1-second (FEV1), Best measure	4.3	13.7	23.1	4.1	1.0	-4.8
Medication: Ibuprofen	4.3	5.2	7.9	2.8	-0.2	-2.8
Illnesses of father: Heart disease	4.3	5.9	9.4	-2.8	0.7	3.1
Fractured/broken bones in last 5 years	3.8	4.9	7.5	2.6	0.4	-2.7
Diabetes (mother)	3.7	4.8	6.2	-2.0	-2.5	2.0
Illnesses of siblings: Diabetes	3.7	4.6	7.0	-2.6	-0.3	2.6
Medication for hormone replacement therapy	3.6	4.0	6.2	2.4	0.4	-2.5
Medication: Blood pressure	3.6	6.8	12.0	-2.7	-1.1	3.5
Townsend deprivation index at recruitment	3.5	4.9	7.3	2.7	0.3	-2.7
Hearing difficulty/problems with background noise	3.5	5.6	10.0	2.6	-0.3	-3.2
Peak expiratory flow (PEF)	3.5	8.1	13.0	3.1	1.2	-3.6
Neuroticism (2016)	3.4	4.8	6.6	-2.5	1.3	2.6
Medication: Atorvastatin	3.4	4.2	6.7	-2.6	0.4	2.4
Crohns Disease (2012)	3.3	5.3	6.2	-2.2	-2.5	2.2
Pulse wave Arterial Stiffness index	3.3	3.8	5.7	2.2	1.0	-2.4
Lupus	3.2	4.8	14.3	-0.2	3.8	0.0
Bilateral oophorectomy (both ovaries removed)	3.2	3.7	4.5	-1.6	-2.0	2.1
Medication: Gliclazide	3.2	3.6	5.0	-1.2	2.2	2.0
Age at First Birth	3.1	4.4	6.2	2.3	1.3	-2.5
Illnesses of siblings	3.1	4.4	6.9	2.6	0.5	-2.5
Length of working week for main job	3.1	3.4	5.6	-2.4	0.6	2.1
Pain experienced in last month	3.1	5.2	9.1	-3.0	0.7	2.5
Breast Cancer	3.0	7.2	13.1	-3.6	0.7	2.8
Medication: Paracetamol	3.0	5.1	7.2	2.4	-1.4	-2.7
Illness, injury, bereavement, stress in last 2 years	3.0	3.6	7.4	-1.2	-2.7	1.5
Hand grip strength (right)	2.8	7.6	12.2	3.5	1.0	-3.1
Back pain experienced in last month	2.8	4.1	6.8	2.3	-0.5	-2.6
Crohns Disease (2017)	2.6	5.8	6.8	-2.6	-2.1	2.4
Hypothyroidism/myxoedema (self-reported)	2.6	5.1	7.6	2.2	-1.7	-2.7
Medication for cholesterol	2.6	4.0	6.2	1.9	1.5	-2.5
Irritable Bowel Disease (IBD)	2.5	6.0	9.0	-2.5	-1.6	3.0
Blood Platelet Count	2.5	28.5	46.6	-5.9	1.9	6.8
Sensitivity / hurt feelings	2.5	4.2	6.9	-2.1	1.3	2.6
Illnesses of father: High blood pressure	2.5	3.1	6.2	-1.8	-0.0	2.5
Type 2 Diabetes (T2D) (2018)	2.4	4.5	7.7	-2.8	0.8	2.3
Hypertension (Self-reported)	2.4	6.6	11.1	-2.5	1.6	3.3
Impedance of leg (right)	2.3	11.0	19.4	-3.7	0.1	4.4
Trunk fat percentage	2.3	9.1	14.8	3.5	-0.2	-3.8
Pulse wave reflection index	2.3	2.8	3.1	1.7	1.5	-1.8
Average weekly red wine intake	2.3	3.4	5.4	-2.3	-1.1	1.9
Heart disease (siblings)	2.3	2.8	4.2	-2.0	-1.7	1.1
Triglycerides	2.2	3.7	5.2	-2.2	0.9	2.3
Hand grip strength (left)	2.2	5.7	9.0	3.0	0.9	-2.7
Stomach or abdominal pain in last month	2.2	2.8	5.4	-0.7	2.3	1.5
Impedance of leg (left)	2.2	10.8	18.1	-3.8	0.2	4.3
Emphysema/chronic bronchitis	2.2	2.5	4.4	2.1	-0.3	-1.8
Other serious medical condition/disability diagnosed by doctor	2.1	2.8	3.2	1.8	1.8	-1.4
High blood pressure	2.1	6.0	10.6	-2.4	1.3	3.3
Mouth/teeth dental problems: Bleeding gums	2.1	2.8	4.9	1.8	0.3	-2.2
High cholesterol (Self-reported)	2.1	3.7	6.6	-2.1	-0.5	2.6
Myopia	2.1	3.1	4.8	1.3	-1.7	-2.2
Vascular/heart problems diagnosed by doctor	2.1	5.6	9.9	2.3	-1.2	-3.1
Hearing difficulty/problems: Yes	2.0	3.1	5.0	2.2	0.0	-2.1
Headache pain in last month	2.0	3.4	5.1	2.3	-1.7	-1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.0	2.4	3.2	1.8	1.0	-1.7
Medication: Lisinopril	2.0	2.6	4.0	-2.0	-0.1	2.0
Ovarian Cancer	1.9	2.5	4.3	-1.3	1.2	2.1
Qualifications: A levels/AS levels or equivalent	1.9	4.3	7.0	-2.6	1.3	2.1
Lung cancer (father)	1.9	2.3	4.0	1.6	-0.6	-2.0
Exposure to tobacco smoke outside home	1.9	2.5	3.5	1.5	-1.9	-1.4
Supplements: Vitamin C	1.9	2.3	3.0	1.7	-1.2	-1.6
Smoking status: Current	1.9	3.0	4.4	2.1	0.7	-2.0
Maternal smoking around birth	1.8	2.6	4.7	2.2	-0.5	-1.7
Gout (self-reported)	1.8	2.4	3.3	1.8	-0.9	-1.8
Ever taken oral contraceptive pill	1.8	2.1	2.8	-1.7	-0.8	1.7
Hearing aid user	1.8	2.0	2.9	1.7	0.6	-1.7
Impedance of whole body	1.8	9.1	15.1	-3.4	-0.8	3.9
HbA1C	1.7	1.9	4.2	-2.1	0.7	1.0
Medication: Aspirin	1.7	2.3	3.8	-1.7	-0.3	1.9
Smoking Status	1.6	3.8	5.3	1.9	1.5	-2.3
Hypothyroidism (self reported)	1.6	3.6	6.4	2.0	-0.5	-2.5
Eye problems/disorders: Diabetes related eye disease	1.6	1.7	1.9	-1.2	-1.3	1.4
Family relationship satisfaction	1.6	2.0	2.8	-1.4	-1.1	1.7
Medication: Paracetamol	1.6	2.4	2.6	1.6	-1.5	-1.6
Ulcerative Colitis (UC)	1.5	2.8	5.4	-1.4	-1.1	2.3
Medication: Metformin	1.5	2.1	2.9	-1.7	0.8	1.7
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	5.2	-0.2	-2.3	0.4
Medication for cholesterol, blood pressure or diabetes	1.5	2.5	3.5	1.9	-0.8	-1.8
Diabetes diagnosed by doctor	1.5	2.4	4.0	-2.0	0.6	1.7
Vitamin and mineral supplements	1.4	1.8	1.9	-1.3	1.4	1.4
Diabetes (father)	1.4	1.8	3.0	-1.7	1.3	0.9
Qualifications: None of the above	1.4	3.0	4.4	2.0	-0.9	-2.1
Financial difficulties in last 2 years	1.4	1.9	5.6	-0.2	2.4	-0.0
Diabetes (self-reported)	1.4	2.2	3.8	-1.9	-0.0	1.7
Number of full sisters	1.4	1.8	2.5	-1.6	0.6	1.6
Commuting to job workplace: Cycle	1.4	1.7	2.8	-1.5	0.4	1.7
Bipolar Disorder (2011)	1.3	1.2	3.3	0.4	1.8	-0.4
Type 2 Diabetes (T2D) (2012)	1.3	1.5	3.3	-1.0	1.8	-0.5
Ulcerative Colitis	1.3	1.9	2.4	-1.0	-1.5	1.5
Respiratory disease	1.3	2.8	4.6	2.1	1.3	-1.5
Ever had hysterectomy (womb removed)	1.3	1.5	2.4	-1.3	-0.6	1.5
Current tobacco smoking	1.3	2.2	3.0	1.6	0.9	-1.7
Alcohol usually taken with meals	1.3	2.1	3.9	-2.0	-0.3	1.5
Hair/balding pattern: Pattern 2	1.3	1.7	2.2	-1.2	1.5	1.2
Impedance of arm (left)	1.3	5.9	8.5	-2.6	-1.5	2.9
Osteoporosis (self-reported)	1.3	1.6	3.3	-1.2	-0.1	1.8
Medication: Aspirin	1.3	1.7	2.7	-1.4	-0.6	1.6
Mother’s age at death	1.3	1.6	2.1	1.2	-1.2	-1.4
Multivitamins +/- minerals	1.2	1.5	1.7	1.3	-1.1	-1.3
Nervous feelings	1.2	2.2	3.5	-1.7	0.1	1.9
Pain all over the body in last month	1.2	1.3	1.6	1.3	-1.0	-1.1
Exposure to tobacco smoke at home	1.2	1.4	2.2	1.0	-1.5	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	3.9	0.1	-2.0	0.4
Medication: Bendroflumethiazide	1.2	1.8	3.4	-1.8	-0.2	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	1.7	1.3	1.1	-1.2
Medication: Simvastatin	1.1	1.6	2.6	-1.5	0.4	1.6
Hair/balding pattern: Pattern 4	1.1	2.6	3.8	-1.9	1.3	1.5
Number of children fathered	1.1	1.2	1.7	-1.0	0.9	1.3
Medication for pain relief, constipation, heartburn	1.1	1.9	2.4	-1.6	1.2	1.3
Neck or shoulder pain in last month	1.1	1.6	2.5	1.6	0.9	-1.3
Heart disease (mother)	1.1	1.3	3.9	-0.0	-2.0	-0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	1.8	-1.3	-0.6	1.3
Commuting to job workplace: Public transport	1.1	1.3	3.4	-0.0	1.9	-0.7
Bipolar Disorder (2018)	1.0	1.6	3.1	0.4	1.8	1.2
Alzheimer’s Disease (in mother)	1.0	1.1	2.6	0.7	-0.6	-1.6
Major Depression (MDD)	1.0	1.2	1.8	-0.9	1.0	1.4
Supplements: Zinc	1.0	1.1	1.3	1.0	-1.0	-1.2
Medication: Levothyroxine sodium	1.0	1.7	2.4	1.4	-0.9	-1.5
High blood pressure (mother)	1.0	1.5	2.4	-1.5	0.3	1.4
Past tobacco smoking	1.0	1.8	3.0	-1.6	-0.2	1.7
Fluid intelligence score	1.0	2.0	2.7	-1.6	1.0	1.5
Number of live births	1.0	1.4	2.6	-1.1	0.6	1.6
Depression (self-reported)	1.0	1.2	1.7	-1.3	-0.4	1.3
Body fat percentage	1.0	3.8	6.5	2.2	-0.1	-2.5
Medication: Allopurinol	1.0	1.3	1.7	1.3	-0.8	-1.3
Alcohol intake frequency.	1.0	2.4	3.8	1.9	0.5	-1.8
Age at last live birth	1.0	1.4	1.9	-1.3	0.8	1.4
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	2.1	1.0	-0.2	-1.5
Ever smoked	1.0	1.7	2.6	1.2	0.9	-1.6
Waist Hip Ratio (WHR)	0.9	3.9	5.1	-2.2	-1.9	1.8
Lung FVC	0.9	4.3	5.2	-2.2	1.7	2.3
Frequency of depressed mood in last 2 weeks	0.9	1.3	3.0	1.0	1.7	-0.1
Relative age voice broke	0.9	1.3	2.0	1.3	-1.4	-0.7
Supplements: Glucosamine	0.9	1.2	2.0	1.4	0.2	-1.2
Chronic bronchitis/emphysema (father)	0.9	1.0	2.1	1.4	-0.0	-1.0
Father’s age at death	0.9	1.2	1.7	1.0	1.3	-0.9
Worrier / anxious feelings	0.9	1.6	2.8	-1.4	0.0	1.7
Asthma	0.9	1.7	2.7	1.6	-0.0	-1.6
Medication: Lansoprazole	0.9	1.1	1.4	-1.2	-0.7	1.1
Diastolic blood pressure, automated reading	0.9	2.9	7.4	2.7	0.0	-1.2
Alzheimer’s Disease (in father)	0.8	0.9	1.3	-1.1	1.2	0.5
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.4	1.2	0.1	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	2.5	1.1	0.4	-1.6
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	1.7	-0.8	1.3	0.4
Loud music exposure frequency	0.8	0.8	1.8	1.3	0.1	-0.9
High blood pressure (siblings)	0.8	1.2	1.9	-1.4	-0.4	1.2
Shortness of breath walking on level ground	0.8	1.0	2.0	0.9	0.4	-1.4
Qualifications: College or University degree	0.8	2.6	4.1	-2.0	1.1	1.6
Asthma (self-reported)	0.8	1.5	2.3	1.5	0.0	-1.5
Average weekly champagne plus white wine intake	0.8	1.1	2.0	1.0	1.4	-0.4
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.9	-0.1	1.7	0.0
Basal cell carcinoma (self-reported)	0.8	0.9	1.9	1.4	0.2	-0.9
Verbal and Numeric Reasoning (VNR)	0.7	1.8	3.0	-1.5	-0.1	1.7
Average weekly fortified wine intake	0.7	0.8	1.6	0.7	-0.6	-1.3
Had menopause	0.7	0.8	1.4	-1.0	-0.1	1.2
Knee pain experienced in last month	0.7	1.1	2.5	0.7	-1.6	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.5	-0.8	-0.6	1.2
Number of operations (self-reported)	0.7	1.0	1.9	1.4	-0.5	-0.9
Risk taking	0.7	1.1	1.8	1.2	-0.1	-1.3
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.0	-0.7	1.0	1.0
Coronary Artery Disease (CAD)	0.6	0.8	1.7	-0.6	0.4	1.3
Fasting Glucose	0.6	0.7	1.3	-0.8	-1.1	-0.3
Serious illness, injury or assault to yourself	0.6	0.7	1.8	0.2	1.4	-0.5
Body mass index (BMI)	0.6	2.5	4.6	1.7	-0.1	-2.1
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.6	-0.7	1.2	0.4
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.5	-0.3	-1.0	1.2
Falls in the last year	0.6	0.7	2.0	0.4	0.4	-1.4
Hair/balding pattern: Pattern 3	0.6	0.9	1.4	1.2	-0.5	-1.1
Medication: Cholesterol lowering	0.6	1.0	1.7	-1.0	0.6	1.3
Glaucoma (self-reported)	0.6	0.7	1.1	1.1	0.8	-0.5
Number of full brothers	0.6	0.7	1.0	1.0	0.9	-0.5
Worry too long after embarrassment	0.6	1.0	1.4	1.2	1.0	-0.8
Wheeze or whistling in the chest in last year	0.6	1.1	2.2	-0.7	1.5	0.7
Pulse wave peak to peak time	0.6	0.7	1.1	-0.6	-1.0	0.8
Leg pain on walking	0.6	0.8	1.5	0.8	-0.6	-1.2
Mood swings	0.6	1.2	2.2	-1.0	0.4	1.5
Mineral and other dietary supplements	0.6	0.8	1.3	-1.2	0.7	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	1.8	-1.3	0.7	1.3
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.4	-1.2	0.2	0.8
Irritability	0.6	1.0	1.4	1.2	-0.6	-1.1
Age started oral contraceptive pill	0.6	0.8	1.3	-1.2	-0.6	0.8
Intelligence (Savage-Jansen 2018)	0.5	1.6	2.7	-1.6	-0.1	1.5
Neuroticism	0.5	1.1	1.4	-0.8	-1.2	1.2
Relative age of first facial hair	0.5	1.1	2.6	0.8	-1.6	-0.2
Angina	0.5	0.7	0.9	-1.0	-0.8	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.3	1.1	0.3	-0.9
Arm fat percentage (right)	0.5	2.1	3.8	1.6	-0.3	-1.9
Time employed in main current job	0.5	0.6	0.9	0.7	0.9	-0.5
Breastfed as a baby	0.5	0.6	0.9	0.8	0.9	-0.5
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.5	-0.4	1.2	0.4
Qualifications: O levels/GCSEs or equivalent	0.5	0.9	1.4	-1.2	0.5	1.0
Blood clot in the leg (DVT)	0.5	0.7	1.2	0.9	-0.1	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.3	-1.1	0.0	0.9
Health satisfaction	0.5	0.6	0.9	-0.9	0.8	0.5
Angina (self-reported)	0.5	0.6	0.9	-0.9	-0.7	0.6
Had major operations	0.5	0.6	1.0	0.8	0.4	-1.0
Eye problems/disorders: Cataract	0.5	0.6	0.7	0.9	0.5	-0.8
Breast cancer (self-reported)	0.5	0.6	1.6	-0.1	-1.3	-0.1
Wears glasses or contact lenses	0.5	0.6	0.9	-1.0	-0.1	0.9
Pack years of smoking	0.5	0.8	1.0	0.9	-1.0	-0.7
Blood Red Count	0.4	4.1	8.1	-1.6	-2.8	1.3
BMI	0.4	2.4	5.0	1.4	-0.0	-2.2
Allergy or Eczema	0.4	1.0	1.5	-1.0	-1.2	0.6
Number of treatments/medications taken	0.4	0.6	1.3	-0.2	-1.2	0.7
Taking other prescription medications	0.4	0.6	1.1	1.1	-0.4	-0.7
Number of incorrect matches in round	0.4	0.6	1.2	0.8	-0.1	-1.1
Allergy	0.4	1.0	1.5	-0.8	0.9	1.2
Illnesses of mother	0.4	0.5	1.1	0.5	1.0	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.0	-1.0	-0.6	0.7
Birth weight of first child	0.4	0.8	1.9	0.5	1.4	-0.4
Medication: Blood pressure	0.4	0.7	0.8	-0.9	0.6	0.9
Friendships satisfaction	0.4	0.5	0.6	-0.6	-0.7	0.7
Number of self-reported non-cancer illnesses	0.4	0.7	1.9	1.4	0.3	-0.5
Guilty feelings	0.4	0.6	0.8	0.8	0.9	-0.6
Supplements: Fish oil (including cod liver oil)	0.4	0.5	0.8	0.9	-0.8	-0.4
Alcohol drinker status: Never	0.4	0.4	0.8	0.5	-0.5	-0.9
Unable to work because of sickness or disability	0.4	0.5	0.7	0.8	0.6	-0.6
Depressed Affect (Nagel 2018)	0.3	0.5	0.9	-0.3	-0.8	1.0
Depression (Nagel 2018)	0.3	0.4	1.0	0.1	1.0	0.4
Schizophrenia vs Biploar Disorder	0.3	0.4	1.1	0.2	-1.1	-0.3
Worry (Nagel 2018)	0.3	0.7	0.9	-0.4	-1.0	0.9
Reaction Time	0.3	0.5	1.1	-0.6	1.0	-0.0
Prostate Cancer	0.3	0.5	0.8	0.4	-0.7	-0.9
Body Mass Index (BMI) (2010)	0.3	0.3	0.6	-0.6	-0.1	0.8
Severe depression (siblings)	0.3	0.3	0.8	0.0	-0.3	-0.9
Pack years adult smoking proportion	0.3	0.4	0.5	0.6	-0.7	-0.7
Mouth/teeth dental problems	0.3	0.4	0.9	-0.1	-1.0	0.5
Impedance of arm (right)	0.3	1.4	2.3	-1.1	-0.9	1.5
Alcohol intake versus 10 years previously	0.3	0.4	0.5	0.7	0.7	-0.5
Happiness	0.3	0.3	0.5	-0.6	0.4	0.7
Tense / ‘highly strung’	0.3	0.6	0.7	0.6	-0.8	-0.8
Eye problems/disorders: None of the above	0.3	0.4	0.7	-0.8	-0.5	0.4
Financial situation satisfaction	0.3	0.3	0.9	0.4	-0.9	-0.2
Eye problems/disorders: Glaucoma	0.3	0.3	0.8	-0.1	-0.9	0.3
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.6	0.6	-0.6	-0.8
Alcohol drinker status: Previous	0.3	0.3	0.6	0.8	0.1	-0.6
Bipolar Disorder or Schizophrenia	0.2	0.6	1.1	0.3	1.1	0.7
Neuroticism (Nagel 2018)	0.2	0.5	0.7	-0.3	-0.8	0.9
Alzheimer’s Disease (including proxy)	0.2	0.2	0.6	-0.8	0.3	0.0
Mean Putamen Volume	0.2	0.2	0.4	0.3	0.4	-0.7
HDL Cholesterol	0.2	0.4	0.8	0.9	0.5	-0.5
Primary Biliary Cirrhosis	0.2	0.3	0.6	-0.3	0.8	0.5
Lung FEV1/FVC ratio	0.2	0.9	2.3	-1.5	0.1	0.7
Average weekly spirits intake	0.2	0.2	0.5	0.7	-0.3	-0.2
Age when periods started (menarche)	0.2	0.5	1.0	1.0	0.3	-0.5
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.5	-0.2	-1.2	-0.2
Had other major operations	0.2	0.2	0.3	-0.4	-0.5	0.4
Heart attack	0.2	0.3	0.6	-0.8	0.4	-0.3
Medication: Ramipril	0.2	0.3	0.7	-0.8	-0.3	-0.1
Neuroticism score	0.2	0.5	1.0	-0.7	-0.1	1.0
Pulse rate	0.2	0.3	0.9	0.2	-0.9	-0.2
Noisy workplace	0.2	0.3	0.4	0.5	0.6	-0.5
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.4	0.6	-0.1	-0.7
Comparative body size at age 10	0.2	0.4	0.8	-0.7	0.9	0.2
Pulse rate, automated reading	0.2	0.7	2.0	0.2	-1.4	0.3
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.4	-0.1	-0.6	0.6
Arm fat percentage (left)	0.2	0.9	1.6	0.8	-0.6	-1.3
Loneliness, isolation	0.2	0.3	0.5	0.6	-0.7	-0.3
Long-standing illness, disability or infirmity	0.2	0.3	0.6	0.7	-0.1	-0.5
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.4	-0.6	0.3	-0.4
Schizophrenia (2014)	0.1	0.2	0.3	0.2	0.6	0.3
Chronotype (morning person)	0.1	0.1	0.2	-0.4	-0.4	0.3
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	0.4	0.2	0.2
Medication: Co-codamol	0.1	0.1	0.2	-0.4	0.2	0.4
Fed-up feelings	0.1	0.1	0.3	0.5	-0.3	-0.2
Medication: Atenolol	0.1	0.1	0.3	0.3	-0.5	0.0
Prospective memory result	0.1	0.1	0.1	-0.2	-0.4	-0.1
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.3	0.6	0.0	-0.5
Age at first live birth	0.1	0.2	0.5	-0.7	0.1	0.5
Medication: Seretide 50 evohaler	0.1	0.1	0.3	-0.2	0.6	0.1
Mean time to correctly identify matches	0.1	0.1	0.2	-0.2	0.4	-0.3
Suffer from ‘nerves’	0.1	0.2	0.3	0.5	0.4	-0.2
Overall health rating	0.1	0.2	0.5	0.2	0.7	-0.1
Chest pain or discomfort	0.1	0.1	0.3	-0.3	0.5	0.2
Smoking status: Previous	0.1	0.2	0.3	0.3	-0.3	-0.5
Osteoarthritis (self-reported)	0.1	0.1	0.2	-0.3	0.2	0.5
Miserableness	0.1	0.1	0.3	0.1	0.6	0.2
Ever depressed for a whole week	0.1	0.1	0.1	-0.2	0.3	0.4
Supplements: Calcium	0.1	0.2	0.2	-0.1	-0.5	-0.5
Schizophrenia (2018)	0.0	0.0	0.0	0.1	-0.1	-0.1
Hair Pigment	0.0	1.1	2.5	0.1	-1.6	0.9
Tanning	0.0	0.4	0.5	-0.7	-0.6	0.6
Mouth/teeth dental problems: Dentures	0.0	0.0	0.1	0.1	0.1	0.2
Leg fat percentage (right)	0.0	0.0	0.0	-0.1	-0.0	-0.1
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.0	-0.0	-0.1	0.0
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.1	0.1	-0.0	0.3	0.3
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.1	-0.3	0.2	-0.1
Qualifications: nursing, teaching	0.0	0.0	0.0	0.2	0.2	-0.0
Commuting to job workplace: Walk	0.0	0.0	0.1	-0.1	0.3	-0.0
Leg fat percentage (left)	0.0	0.1	0.1	-0.1	0.2	-0.3
Average weekly beer plus cider intake	0.0	0.0	0.0	-0.1	0.2	-0.0

Hub : Genes

CDK6

Models

Trait associations