Best TWAS P=5.79e-12 · Best GWAS P=4.27e-12 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | STX17 | 0.12 | 0.09 | lasso | 3 | 0.11 | 1.5e-09 | 5.4 | 5.2 | 2.1e-07 | 0.57 | 0.99 | 0.01 | FALSE |
2 | GTEx | Adipose Visceral Omentum | STX17 | 0.14 | 0.10 | lasso | 7 | 0.10 | 4.6e-06 | -4.9 | 5.1 | 2.7e-07 | 0.55 | 0.97 | 0.01 | FALSE |
3 | GTEx | Artery Tibial | STX17 | 0.07 | 0.05 | lasso | 2 | 0.06 | 1.4e-05 | -4.9 | 5.4 | 7.8e-08 | 0.57 | 0.95 | 0.02 | FALSE |
4 | GTEx | Cells EBV-transformed lymphocytes | INVS | 0.14 | 0.04 | lasso | 10 | 0.04 | 1.4e-02 | 5.4 | 5.4 | 5.4e-08 | 0.59 | 0.35 | 0.27 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | INVS | 0.16 | 0.10 | enet | 17 | 0.17 | 8.0e-13 | 5.7 | 5.6 | 2.2e-08 | 0.61 | 0.93 | 0.07 | FALSE |
6 | GTEx | Esophagus Mucosa | STX17 | 0.19 | 0.26 | lasso | 9 | 0.27 | 2.5e-18 | 5.3 | 5.4 | 7.5e-08 | 0.58 | 0.99 | 0.01 | FALSE |
7 | GTEx | Esophagus Muscularis | INVS | 0.21 | 0.16 | lasso | 5 | 0.22 | 8.9e-14 | 5.7 | 5.6 | 2.6e-08 | 0.73 | 0.49 | 0.51 | FALSE |
8 | GTEx | Heart Atrial Appendage | INVS | 0.08 | 0.03 | lasso | 3 | 0.04 | 4.9e-03 | -4.8 | 5.9 | 3.7e-09 | 0.77 | 0.08 | 0.84 | FALSE |
9 | GTEx | Heart Left Ventricle | INVS | 0.11 | 0.05 | enet | 15 | 0.04 | 2.6e-03 | 2.3 | 5.4 | 6.9e-08 | 0.72 | 0.04 | 0.84 | FALSE |
10 | GTEx | Muscle Skeletal | INVS | 0.12 | 0.03 | lasso | 10 | 0.10 | 1.3e-09 | 5.7 | 5.1 | 3.0e-07 | 0.73 | 0.07 | 0.92 | FALSE |
11 | GTEx | Skin Not Sun Exposed Suprapubic | TEX10 | 0.10 | 0.09 | lasso | 4 | 0.10 | 3.1e-06 | 5.7 | 6.7 | 2.7e-11 | 0.92 | 0.02 | 0.98 | FALSE |
12 | GTEx | Skin Sun Exposed Lower leg | INVS | 0.19 | 0.06 | enet | 30 | 0.11 | 1.5e-09 | 5.7 | 5.7 | 1.4e-08 | 0.79 | 0.02 | 0.98 | FALSE |
13 | GTEx | Skin Sun Exposed Lower leg | TEX10 | 0.27 | 0.27 | lasso | 8 | 0.28 | 7.0e-23 | 6.9 | 6.9 | 5.8e-12 | 1.00 | 0.01 | 0.99 | TRUE |
14 | GTEx | Stomach | INVS | 0.23 | 0.13 | lasso | 9 | 0.14 | 4.4e-07 | -4.9 | 5.3 | 1.3e-07 | 0.55 | 0.94 | 0.05 | FALSE |
15 | YFS | Blood | INVS | 0.15 | 0.14 | lasso | 7 | 0.24 | 1.4e-77 | 2.5 | 5.8 | 5.0e-09 | 0.78 | 0.02 | 0.98 | FALSE |
16 | YFS | Blood | TEX10 | 0.03 | 0.02 | blup | 368 | 0.02 | 1.7e-06 | 5.7 | -5.8 | 8.6e-09 | -0.76 | 0.03 | 0.97 | FALSE |
17 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | INVS | 0.27 | 0.05 | lasso | 8 | 0.13 | 3.4e-11 | 5.7 | 5.7 | 1.4e-08 | 0.68 | 0.20 | 0.80 | FALSE |
18 | The Cancer Genome Atlas | Breast Invasive Carcinoma | INVS | 0.22 | 0.04 | lasso | 9 | 0.07 | 7.3e-15 | 5.4 | 5.1 | 2.9e-07 | 0.71 | 0.52 | 0.48 | FALSE |
19 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | INVS | 0.10 | 0.03 | blup | 107 | 0.07 | 4.0e-04 | 6.7 | 6.7 | 1.8e-11 | 0.89 | 0.01 | 0.96 | FALSE |
20 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | INVS | 0.10 | 0.08 | lasso | 5 | 0.07 | 3.4e-08 | -4.5 | 5.3 | 1.4e-07 | 0.58 | 1.00 | 0.00 | FALSE |
21 | The Cancer Genome Atlas | Lung Adenocarcinoma | INVS | 0.08 | 0.06 | blup | 106 | 0.07 | 7.0e-09 | -4.8 | 6.0 | 2.0e-09 | 0.70 | 0.95 | 0.05 | FALSE |
22 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | INVS | 0.09 | 0.02 | enet | 11 | 0.04 | 4.0e-05 | 5.7 | 5.9 | 2.7e-09 | 0.66 | 0.02 | 0.77 | FALSE |
23 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | INVS | 0.16 | 0.12 | enet | 8 | 0.08 | 2.8e-04 | 5.4 | 5.7 | 1.1e-08 | 0.77 | 0.26 | 0.62 | FALSE |
24 | The Cancer Genome Atlas | Prostate Adenocarcinoma | INVS | 0.09 | 0.04 | enet | 14 | 0.06 | 1.5e-06 | 5.7 | 5.8 | 5.1e-09 | 0.75 | 0.04 | 0.94 | FALSE |
25 | The Cancer Genome Atlas | Thyroid Carcinoma | INVS | 0.21 | 0.07 | enet | 13 | 0.18 | 4.0e-17 | -4.7 | 5.3 | 1.2e-07 | 0.71 | 0.26 | 0.74 | FALSE |
26 | The Cancer Genome Atlas | Thyroid Carcinoma | STX17 | 0.07 | 0.03 | blup | 56 | 0.05 | 2.2e-05 | -4.9 | 5.1 | 2.6e-07 | 0.55 | 0.01 | 0.95 | FALSE |