Best TWAS P=1.41e-11 · Best GWAS P=3.29e-11 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | WDR78 | 0.14 | 0.09 | lasso | 8 | 0.09 | 2.1e-07 | -6.6 | 6.8 | 1.4e-11 | -0.96 | 0.02 | 0.98 | TRUE |
| 2 | GTEx | Artery Tibial | MIER1 | 0.12 | 0.08 | lasso | 4 | 0.07 | 6.3e-06 | -6.6 | -6.6 | 4.8e-11 | 0.99 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Breast Mammary Tissue | MIER1 | 0.12 | 0.07 | lasso | 2 | 0.05 | 8.5e-04 | -6.3 | -6.4 | 2.0e-10 | 0.84 | 0.03 | 0.92 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | MIER1 | 0.19 | 0.09 | lasso | 7 | 0.10 | 3.1e-08 | -4.6 | -5.5 | 4.0e-08 | 0.92 | 0.06 | 0.94 | FALSE |
| 5 | GTEx | Esophagus Muscularis | MIER1 | 0.14 | 0.05 | enet | 9 | 0.04 | 2.5e-03 | -6.6 | -6.5 | 1.0e-10 | 0.93 | 0.03 | 0.94 | FALSE |
| 6 | GTEx | Nerve Tibial | WDR78 | 0.13 | 0.07 | lasso | 5 | 0.06 | 7.5e-05 | -6.6 | 6.0 | 2.1e-09 | -0.94 | 0.02 | 0.97 | FALSE |
| 7 | GTEx | Testis | WDR78 | 0.45 | 0.42 | lasso | 6 | 0.40 | 5.0e-19 | -6.6 | -6.6 | 3.1e-11 | 0.98 | 0.02 | 0.98 | FALSE |
| 8 | GTEx | Thyroid | WDR78 | 0.12 | 0.11 | lasso | 3 | 0.09 | 2.4e-07 | -6.6 | 6.7 | 2.2e-11 | -0.97 | 0.03 | 0.97 | FALSE |
| 9 | METSIM | Adipose | MIER1 | 0.05 | 0.05 | enet | 19 | 0.04 | 2.8e-07 | -4.6 | -6.1 | 1.1e-09 | 0.98 | 0.03 | 0.97 | FALSE |
| 10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | WDR78 | 0.02 | 0.01 | blup | 86 | 0.02 | 2.4e-04 | -6.6 | 5.4 | 7.4e-08 | -0.80 | 0.01 | 0.94 | FALSE |