TWAS
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Usage
Models
Genes
Traits
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Traits
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Standing height
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chr1:77,815,519-79,300,939
Best TWAS P=8.4e-09 · Best GWAS P=1.46e-24 conditioned to 1.47e-20
77.8M
78M
78.2M
78.4M
78.6M
78.8M
79M
79.2M
0
5
10
15
20
25
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Lung
GIPC2
0.15
0.09
enet
17
0.12
2.5e-09
-5.4
5.8
8.4e-09
0.19
1.00
0.00
TRUE
5
The Cancer Genome Atlas
Thyroid Carcinoma
GIPC2
0.07
0.05
blup
64
0.06
1.5e-06
-5.5
5.8
8.8e-09
0.28
0.67
0.02
FALSE
4
The Cancer Genome Atlas
Lung Adenocarcinoma
DNAJB4
0.04
0.04
lasso
2
0.04
1.2e-05
5.7
-5.7
1.2e-08
-0.45
0.00
0.99
FALSE
3
The Cancer Genome Atlas
Colon Adenocarcinoma
GIPC2
0.04
0.01
blup
65
0.00
2.5e-01
-4.3
5.6
2.7e-08
0.28
0.07
0.06
FALSE
2
GTEx
Pancreas
GIPC2
0.41
0.13
enet
29
0.14
1.1e-06
-4.1
5.2
1.9e-07
0.31
0.65
0.10
FALSE