TWAS
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Usage
Models
Genes
Traits
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Traits
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Standing height
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chr8:10,265,712-13,120,332
Best TWAS P=4.77e-09 · Best GWAS P=2.07e-10 conditioned to 5.37e-11
10.5M
11M
11.5M
12M
12.5M
13M
0
2
4
6
8
10
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
CommonMind
Brain Pre-frontal Cortex
LOC100506990
0.08
0.03
enet
32
0.05
4.1e-07
-4.6
-5.9
4.8e-09
-0.03
0.01
0.99
TRUE
2
GTEx
Artery Tibial
AF131215.2
0.07
0.03
enet
24
0.05
1.8e-04
2.3
-5.5
4.0e-08
0.02
0.13
0.81
FALSE
3
GTEx
Breast Mammary Tissue
AF131215.9
0.10
0.10
lasso
8
0.12
8.7e-07
4.9
-5.2
1.9e-07
-0.03
0.05
0.94
FALSE
4
ROSMAP
Brain Pre-frontal Cortex
FAM85A
0.11
0.07
enet
23
0.11
4.3e-14
-2.7
-5.2
2.3e-07
-0.06
0.01
0.99
FALSE