Best TWAS P=3.15e-11 · Best GWAS P=1.27e-12 conditioned to 7.9e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellar Hemisphere | FAM86B3P | 0.28 | 0.27 | lasso | 8 | 0.28 | 5.4e-08 | -5.5 | 5.3 | 1.1e-07 | 0.62 | 0.46 | 0.50 | FALSE |
| 2 | GTEx | Brain Cerebellum | FAM86B3P | 0.19 | 0.14 | lasso | 5 | 0.16 | 1.8e-05 | -4.8 | 5.4 | 8.0e-08 | 0.63 | 0.54 | 0.39 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | FAM86B3P | 0.23 | 0.33 | lasso | 11 | 0.38 | 8.4e-30 | -5.0 | -6.0 | 1.8e-09 | -0.63 | 0.85 | 0.15 | FALSE |
| 4 | GTEx | Colon Transverse | FAM86B3P | 0.13 | 0.04 | lasso | 8 | 0.04 | 4.4e-03 | -4.8 | -6.3 | 3.6e-10 | -0.63 | 0.03 | 0.91 | FALSE |
| 5 | GTEx | Esophagus Mucosa | FAM86B3P | 0.22 | 0.17 | lasso | 8 | 0.19 | 1.7e-12 | -5.0 | -5.5 | 4.9e-08 | -0.62 | 0.64 | 0.36 | FALSE |
| 6 | GTEx | Heart Left Ventricle | MFHAS1 | 0.15 | -0.01 | lasso | 3 | 0.00 | 2.2e-01 | 5.1 | -5.1 | 2.9e-07 | -0.43 | 0.08 | 0.52 | FALSE |
| 7 | GTEx | Lung | ERI1 | 0.13 | 0.07 | lasso | 6 | 0.09 | 2.7e-07 | 4.9 | 5.2 | 2.3e-07 | 0.61 | 0.94 | 0.05 | FALSE |
| 8 | GTEx | Lung | AC087269.1 | 0.20 | 0.19 | lasso | 9 | 0.18 | 4.8e-14 | -4.9 | 5.3 | 1.4e-07 | 0.41 | 0.97 | 0.03 | FALSE |
| 9 | GTEx | Lung | CLDN23 | 0.18 | 0.17 | lasso | 7 | 0.16 | 2.5e-12 | -4.9 | 5.3 | 9.5e-08 | 0.40 | 0.97 | 0.03 | FALSE |
| 10 | GTEx | Nerve Tibial | ERI1 | 0.07 | 0.01 | enet | 16 | 0.01 | 4.2e-02 | 4.5 | 5.8 | 5.5e-09 | 0.63 | 0.22 | 0.41 | FALSE |
| 11 | GTEx | Thyroid | SGK223 | 0.19 | 0.35 | enet | 16 | 0.36 | 1.1e-28 | -5.3 | 5.5 | 4.0e-08 | 0.63 | 0.85 | 0.15 | FALSE |
| 12 | NTR | Blood | MFHAS1 | 0.02 | 0.01 | blup | 759 | 0.01 | 2.9e-04 | -5.5 | -6.6 | 3.2e-11 | -0.59 | 0.55 | 0.43 | TRUE |
| 13 | ROSMAP | Brain Pre-frontal Cortex | FAM85B | 0.16 | 0.23 | enet | 18 | 0.22 | 1.8e-28 | -5.0 | 5.4 | 7.0e-08 | 0.63 | 0.97 | 0.03 | FALSE |
| 14 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PPP1R3B | 0.03 | 0.03 | enet | 8 | 0.03 | 1.8e-06 | -4.8 | 5.7 | 1.1e-08 | 0.46 | 0.06 | 0.93 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | FLJ10661 | 0.07 | 0.02 | blup | 42 | 0.04 | 2.9e-03 | -5.5 | -5.5 | 4.1e-08 | -0.61 | 0.00 | 0.95 | FALSE |
| 16 | The Cancer Genome Atlas | Lung Adenocarcinoma | FLJ10661 | 0.06 | 0.05 | lasso | 3 | 0.04 | 2.4e-05 | -5.5 | -5.5 | 4.2e-08 | -0.58 | 0.00 | 1.00 | FALSE |
| 17 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | FLJ10661 | 0.12 | 0.09 | lasso | 4 | 0.08 | 4.7e-09 | -5.0 | -5.4 | 6.9e-08 | -0.60 | 0.01 | 0.99 | FALSE |
| 18 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | FLJ10661 | 0.11 | 0.06 | enet | 5 | 0.07 | 2.3e-05 | -4.8 | -5.8 | 5.4e-09 | -0.60 | 0.02 | 0.86 | FALSE |
| 19 | The Cancer Genome Atlas | Soft Tissue Sarcoma | FLJ10661 | 0.12 | 0.00 | blup | 42 | 0.00 | 6.9e-01 | -4.8 | -5.3 | 1.0e-07 | -0.58 | 0.01 | 0.20 | FALSE |