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chr10:78,845,149-80,387,684

Best TWAS P=3.89e-22 · Best GWAS P=3.28e-19 conditioned to 0.77

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
6	GTEx	Adrenal Gland	DLG5	0.22	0.14	lasso	6	0.11	8.5e-05	-8.9	-9.7	3.9e-22	0.94	0.01	0.99	TRUE
36	GTEx	Ovary	DLG5	0.62	0.38	lasso	6	0.40	5.3e-11	-8.8	-9.5	2.2e-21	0.96	0.01	0.99	FALSE
37	GTEx	Ovary	RP13-39P12.3	0.42	0.29	lasso	5	0.33	7.5e-09	-8.8	-9.4	5.3e-21	0.94	0.02	0.98	FALSE
34	GTEx	Nerve Tibial	DLG5	0.51	0.44	lasso	6	0.50	1.4e-39	-8.9	-9.2	2.4e-20	0.97	0.01	0.99	FALSE
17	GTEx	Cells Transformed fibroblasts	DLG5	0.25	0.18	lasso	11	0.16	2.0e-12	-8.8	-9.1	1.1e-19	0.96	0.02	0.98	FALSE
1	CommonMind	Brain Pre-frontal Cortex	DLG5	0.10	0.07	lasso	5	0.06	3.3e-08	-8.9	-9.0	2.0e-19	0.98	0.01	0.99	FALSE
41	GTEx	Pituitary	RP13-39P12.3	0.38	0.22	lasso	11	0.17	3.8e-05	-8.8	-9.0	2.5e-19	0.95	0.02	0.96	FALSE
49	GTEx	Thyroid	RP13-39P12.3	0.28	0.30	lasso	8	0.29	3.3e-22	-8.9	-9.0	2.6e-19	0.98	0.01	0.99	FALSE
8	GTEx	Artery Aorta	RP13-39P12.3	0.14	0.13	enet	9	0.12	2.2e-07	-8.8	-9.0	2.7e-19	0.97	0.01	0.99	FALSE
40	GTEx	Pituitary	DLG5	0.45	0.36	lasso	11	0.31	1.9e-08	-8.8	-9.0	2.8e-19	0.97	0.01	0.99	FALSE
2	GTEx	Adipose Subcutaneous	DLG5	0.39	0.40	lasso	12	0.43	1.9e-38	-8.9	-9.0	3.1e-19	0.97	0.00	1.00	FALSE
32	GTEx	Lung	DLG5	0.41	0.38	lasso	8	0.37	7.9e-30	-8.9	-9.0	3.2e-19	0.98	0.01	0.99	FALSE
44	GTEx	Spleen	DLG5	0.51	0.46	lasso	4	0.44	1.1e-12	-8.9	-9.0	3.3e-19	0.98	0.01	0.99	FALSE
4	GTEx	Adipose Visceral Omentum	DLG5	0.26	0.23	lasso	8	0.21	5.7e-11	-8.9	-8.9	3.4e-19	0.97	0.01	0.99	FALSE
39	GTEx	Pancreas	RP13-39P12.3	0.20	0.24	lasso	3	0.23	3.8e-10	-8.9	-8.9	4.0e-19	0.98	0.01	0.99	FALSE
48	GTEx	Thyroid	DLG5	0.39	0.43	lasso	5	0.43	1.5e-35	-8.9	-8.9	4.6e-19	0.98	0.01	0.99	FALSE
38	GTEx	Pancreas	DLG5	0.39	0.43	enet	11	0.44	3.5e-20	-8.9	-8.9	5.2e-19	0.99	0.01	0.99	FALSE
43	GTEx	Skin Sun Exposed Lower leg	DLG5	0.12	0.06	lasso	4	0.06	4.9e-06	-8.9	-8.9	5.9e-19	0.97	0.01	0.99	FALSE
7	GTEx	Artery Aorta	DLG5	0.26	0.19	enet	10	0.22	2.6e-12	-8.8	-8.9	6.9e-19	0.98	0.01	0.99	FALSE
46	GTEx	Stomach	DLG5	0.20	0.12	lasso	7	0.08	1.3e-04	-8.9	-8.9	7.4e-19	0.98	0.01	0.99	FALSE
11	GTEx	Artery Tibial	DLG5	0.24	0.18	lasso	5	0.18	9.7e-14	-8.9	-8.9	7.5e-19	0.98	0.01	0.99	FALSE
27	GTEx	Heart Atrial Appendage	DLG5	0.32	0.23	lasso	4	0.24	3.9e-11	-8.7	-8.8	9.5e-19	0.97	0.01	0.99	FALSE
29	GTEx	Heart Left Ventricle	DLG5	0.13	0.10	lasso	4	0.09	1.2e-05	-8.7	-8.8	1.1e-18	0.97	0.01	0.99	FALSE
21	GTEx	Colon Transverse	DLG5	0.23	0.17	lasso	8	0.19	1.4e-09	-8.7	-8.8	2.2e-18	0.94	0.01	0.99	FALSE
45	GTEx	Spleen	RP13-39P12.3	0.38	0.34	lasso	2	0.35	8.8e-10	-8.9	-8.8	2.2e-18	0.94	0.01	0.99	FALSE
24	GTEx	Esophagus Mucosa	DLG5	0.21	0.16	lasso	5	0.18	5.2e-12	-8.9	-8.7	2.5e-18	0.94	0.01	0.99	FALSE
30	GTEx	Liver	DLG5	0.42	0.31	lasso	5	0.28	2.1e-08	-8.8	-8.7	2.5e-18	0.97	0.01	0.99	FALSE
9	GTEx	Artery Coronary	DLG5	0.33	0.25	lasso	4	0.27	1.4e-09	-8.7	-8.7	2.8e-18	0.91	0.01	0.99	FALSE
18	GTEx	Cells Transformed fibroblasts	RP13-39P12.3	0.19	0.13	lasso	7	0.15	4.5e-11	-8.8	-8.7	3.6e-18	0.90	0.02	0.98	FALSE
52	ROSMAP	Brain Pre-frontal Cortex	DLG5	0.19	0.17	bslmm	592	0.20	1.5e-24	-8.8	-8.7	4.5e-18	0.91	0.01	0.99	FALSE
16	GTEx	Breast Mammary Tissue	DLG5	0.15	0.09	lasso	7	0.08	6.7e-05	-8.7	-8.7	4.9e-18	0.93	0.02	0.96	FALSE
35	GTEx	Nerve Tibial	RP13-39P12.3	0.31	0.25	lasso	7	0.36	1.3e-26	-8.9	-8.6	1.2e-17	0.86	0.01	0.99	FALSE
51	METSIM	Adipose	DLG5	0.18	0.19	lasso	11	0.22	2.2e-32	-8.9	-8.5	1.4e-17	0.90	0.01	0.99	FALSE
14	GTEx	Brain Cerebellum	DLG5	0.36	0.28	lasso	7	0.36	1.6e-11	-8.9	-8.5	1.5e-17	0.90	0.01	0.99	FALSE
3	GTEx	Adipose Subcutaneous	RP13-39P12.3	0.31	0.27	lasso	12	0.34	1.1e-28	-8.9	-8.5	2.3e-17	0.90	0.01	0.99	FALSE
64	The Cancer Genome Atlas	Thyroid Carcinoma	DLG5	0.13	0.08	enet	10	0.10	1.2e-09	-8.4	-8.4	5.4e-17	0.85	0.03	0.97	FALSE
57	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	DLG5	0.12	0.01	blup	116	0.03	1.2e-02	-8.7	-8.4	6.1e-17	0.83	0.02	0.66	FALSE
10	GTEx	Artery Coronary	RP13-39P12.3	0.21	0.03	lasso	4	0.09	7.2e-04	-8.7	-8.3	8.5e-17	0.85	0.03	0.94	FALSE
5	GTEx	Adipose Visceral Omentum	RP13-39P12.3	0.18	0.07	lasso	7	0.06	3.3e-04	-8.9	-8.3	1.2e-16	0.87	0.01	0.99	FALSE
12	GTEx	Artery Tibial	RP13-39P12.3	0.14	0.04	lasso	7	0.05	7.3e-05	-8.9	-8.1	5.1e-16	0.85	0.01	0.98	FALSE
33	GTEx	Lung	RP13-39P12.3	0.36	0.28	enet	27	0.31	2.5e-24	-8.9	-8.1	6.1e-16	0.90	0.01	0.99	FALSE
62	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	DLG5	0.15	0.00	blup	116	0.07	6.3e-04	-8.7	-8.0	9.6e-16	0.85	0.01	0.97	FALSE
50	GTEx	Whole Blood	DLG5	0.10	0.06	lasso	9	0.10	2.3e-09	5.0	-8.0	1.6e-15	0.79	0.08	0.92	FALSE
19	GTEx	Colon Sigmoid	DLG5	0.23	0.11	lasso	5	0.15	4.6e-06	4.9	-7.9	3.1e-15	0.82	0.03	0.93	FALSE
23	GTEx	Esophagus Gastroesophageal Junction	DLG5	0.27	0.03	enet	13	0.06	3.9e-03	-8.2	-7.8	8.5e-15	0.73	0.02	0.95	FALSE
31	GTEx	Liver	RP13-39P12.3	0.29	0.03	enet	21	0.07	4.6e-03	-8.8	-7.7	1.1e-14	0.76	0.02	0.93	FALSE
28	GTEx	Heart Atrial Appendage	RP13-39P12.3	0.22	0.11	lasso	4	0.16	7.7e-08	4.9	-7.7	1.5e-14	0.80	0.03	0.96	FALSE
13	GTEx	Brain Cerebellar Hemisphere	DLG5	0.48	0.09	lasso	11	0.21	3.8e-06	4.7	-7.6	3.1e-14	0.82	0.03	0.93	FALSE
47	GTEx	Stomach	RP13-39P12.3	0.17	0.02	lasso	5	0.02	2.5e-02	4.9	-7.5	8.6e-14	0.79	0.02	0.89	FALSE
60	The Cancer Genome Atlas	Brain Lower Grade Glioma	DLG5	0.03	0.01	blup	116	0.02	6.9e-03	4.9	-7.4	1.1e-13	0.75	0.03	0.68	FALSE
63	The Cancer Genome Atlas	Prostate Adenocarcinoma	DLG5	0.10	0.05	blup	116	0.05	2.1e-06	-8.9	-7.4	1.6e-13	0.84	0.01	0.99	FALSE
15	GTEx	Brain Cerebellum	RP13-39P12.3	0.24	0.14	lasso	10	0.17	1.3e-05	5.0	-7.4	1.7e-13	0.72	0.07	0.87	FALSE
59	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	DLG5	0.09	0.05	blup	116	0.07	4.5e-05	4.7	-7.4	1.7e-13	0.78	0.07	0.92	FALSE
26	GTEx	Esophagus Muscularis	DLG5	0.14	0.04	enet	27	0.06	1.9e-04	5.1	-7.2	5.5e-13	0.70	0.06	0.91	FALSE
61	The Cancer Genome Atlas	Lung Adenocarcinoma	DLG5	0.03	0.01	blup	116	0.02	3.1e-03	4.9	-7.1	1.0e-12	0.70	0.06	0.67	FALSE
58	The Cancer Genome Atlas	Colon Adenocarcinoma	DLG5	0.08	0.03	blup	116	0.06	2.1e-04	3.9	-7.0	3.2e-12	0.79	0.06	0.92	FALSE
25	GTEx	Esophagus Mucosa	RP13-39P12.3	0.12	0.04	lasso	2	0.03	2.9e-03	4.8	-6.8	9.1e-12	0.67	0.15	0.82	FALSE
55	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	DLG5	0.08	0.00	blup	116	0.02	4.0e-03	-8.7	-6.7	1.9e-11	0.82	0.01	0.88	FALSE
22	GTEx	Colon Transverse	RP13-39P12.3	0.20	0.14	lasso	5	0.17	1.6e-08	5.0	-6.5	6.2e-11	0.62	0.38	0.62	FALSE
20	GTEx	Colon Sigmoid	RP13-39P12.3	0.18	0.11	lasso	3	0.10	1.6e-04	4.9	-6.4	1.3e-10	0.65	0.16	0.68	FALSE
42	GTEx	Skin Not Sun Exposed Suprapubic	DLG5	0.18	0.01	enet	24	0.13	2.0e-07	-7.8	-6.4	1.3e-10	0.71	0.02	0.97	FALSE
56	The Cancer Genome Atlas	Breast Invasive Carcinoma	DLG5	0.02	0.01	enet	9	0.01	3.5e-03	3.4	-5.8	7.4e-09	0.56	0.10	0.63	FALSE
54	YFS	Blood	DLG5	0.04	0.03	bslmm	583	0.03	2.8e-10	4.8	-5.5	2.9e-08	0.51	1.00	0.00	FALSE
53	ROSMAP	Brain Pre-frontal Cortex	DLG5-AS1	0.07	0.02	blup	505	0.02	4.0e-04	-7.8	5.2	2.4e-07	-0.57	0.03	0.89	FALSE