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chr10:80,410,110-82,223,767

Best TWAS P=2.02e-48 · Best GWAS P=8.21e-40 conditioned to 0.49

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	ZCCHC24	0.12	0.01	lasso	6	0.03	3.4e-03	12.78	14.6	2.0e-48	0.80	0.01	0.98	TRUE
17	ROSMAP	Brain Pre-frontal Cortex	PPIF	0.05	0.01	lasso	4	0.02	2.9e-03	-4.80	5.5	5.1e-08	0.21	0.40	0.08	TRUE
22	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ZCCHC24	0.07	0.05	enet	9	0.04	6.7e-05	11.71	11.6	6.8e-31	0.84	0.06	0.94	FALSE
19	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ZCCHC24	0.06	0.00	blup	89	0.01	6.2e-02	4.40	10.8	2.7e-27	0.48	0.01	0.17	FALSE
14	GTEx	Skin Sun Exposed Lower leg	ZCCHC24	0.09	0.00	enet	18	0.00	2.3e-01	0.87	10.3	7.5e-25	0.39	0.02	0.64	FALSE
15	GTEx	Skin Sun Exposed Lower leg	RP11-342M3.5	0.08	0.00	enet	28	0.01	7.3e-02	0.22	7.8	5.6e-15	0.18	0.05	0.16	FALSE
8	GTEx	Artery Tibial	RP11-506M13.3	0.12	0.06	lasso	5	0.04	3.2e-04	6.26	-7.4	1.1e-13	-0.13	0.49	0.04	FALSE
3	GTEx	Artery Aorta	BEND3P3	0.19	0.05	enet	22	0.09	7.5e-06	3.20	-7.0	3.7e-12	-0.03	0.87	0.02	FALSE
11	GTEx	Heart Atrial Appendage	RP11-119F19.2	0.18	0.03	lasso	7	0.05	2.5e-03	6.22	-6.9	6.1e-12	0.04	0.14	0.05	FALSE
5	GTEx	Artery Coronary	RP11-119F19.2	0.24	0.14	lasso	6	0.12	7.0e-05	7.40	-6.8	1.0e-11	0.01	0.48	0.03	FALSE
23	The Cancer Genome Atlas	Brain Lower Grade Glioma	SFTPA2	0.14	0.08	enet	8	0.10	7.6e-12	4.83	-6.5	1.1e-10	0.02	0.02	0.98	FALSE
21	The Cancer Genome Atlas	Breast Invasive Carcinoma	ZCCHC24	0.03	0.01	blup	89	0.02	2.0e-04	4.46	6.2	6.1e-10	0.18	0.40	0.02	FALSE
6	GTEx	Artery Tibial	BEND3P3	0.22	0.07	enet	14	0.10	5.8e-08	6.26	-6.1	8.7e-10	-0.01	0.97	0.00	FALSE
13	GTEx	Ovary	BEND3P3	0.27	0.09	enet	24	0.09	3.1e-03	0.65	-5.7	1.1e-08	-0.14	0.07	0.12	FALSE
20	The Cancer Genome Atlas	Breast Invasive Carcinoma	SFTPA2	0.06	0.03	enet	12	0.04	2.1e-09	3.20	-5.7	1.1e-08	0.04	0.21	0.79	FALSE
4	GTEx	Artery Aorta	RP11-119F19.2	0.22	0.16	lasso	9	0.18	2.7e-10	6.26	-5.5	3.0e-08	0.03	1.00	0.00	FALSE
16	GTEx	Thyroid	RP11-119F19.2	0.24	0.09	lasso	6	0.17	7.2e-13	3.30	-5.5	3.7e-08	0.02	1.00	0.00	FALSE
2	GTEx	Adipose Visceral Omentum	BEND3P3	0.27	0.13	lasso	10	0.13	3.0e-07	4.70	-5.4	5.4e-08	0.01	1.00	0.00	FALSE
12	GTEx	Lung	RP11-119F19.2	0.24	0.09	lasso	12	0.18	1.5e-13	4.83	-5.4	6.5e-08	0.01	1.00	0.00	FALSE
10	GTEx	Heart Atrial Appendage	BEND3P3	0.20	0.13	enet	14	0.13	2.1e-06	6.24	-5.4	7.4e-08	0.02	0.63	0.02	FALSE
7	GTEx	Artery Tibial	RP11-119F19.2	0.20	0.06	enet	26	0.18	7.2e-14	6.22	-5.4	8.4e-08	0.01	0.99	0.00	FALSE
9	GTEx	Esophagus Mucosa	RP11-119F19.2	0.20	0.10	lasso	5	0.18	2.1e-12	6.22	-5.2	2.2e-07	0.04	1.00	0.00	FALSE
18	ROSMAP	Brain Pre-frontal Cortex	SFTPA2	0.22	0.16	bslmm	349	0.20	2.3e-25	4.49	-5.2	2.7e-07	-0.01	1.00	0.00	FALSE